ライフサイエンスコーパス: kinase activity

1 t both sites, as does the stimulation of ATM kinase activity.

2 oduction, beta-arrestin interaction, and MAP kinase activity.

3 addition, pTRS1 binding to PKR inhibited PKR kinase activity.

4 M1 ubiquitination of RIPK1 to inhibit RIPK1 kinase activity.

5 compounds have been developed to inhibit its kinase activity.

6 ution to allow for a fine tuning of p38alpha kinase activity.

7 on of protein kinase C and receptor tyrosine kinase activity.

8 its ability to stabilize DUSP2 requires its kinase activity.

9 ndent of dietary nutrient conditions and PI3-kinase activity.

10 ion induced constitutive activation of EphA2 kinase activity.

11 olution, which results in inhibition of Chk1 kinase activity.

12 ytosis can be rescued by inhibition of LRRK2 kinase activity.

13 m the Vps34-Vps15 complex independent of its kinase activity.

14 the adaptor protein Disabled stimulates Abl kinase activity.

15 on, but membrane dynamics is reliant on LKB1 kinase activity.

16 GS domain modifications are coupled to STKR1 kinase activity.

17 cium entry (SOCE) as a novel target of TRPM7 kinase activity.

18 n a yeast mutant with defective pantothenate kinase activity.

19 ed to the light-activation of luciferase and kinase activity.

20 mutant LRRK2-induced neurite shortening and kinase activity.

21 ze Cys488 of Fyn, resulting in increased Fyn kinase activity.

22 tationary phase-dependent stimulation of DAG kinase activity.

23 SOBIR1) RLK contributes to RLP stability and kinase activity.

24 otein kinase and mutations lead to increased kinase activity.

25 hese mutations have been linked to increased kinase activity.

26 , we examined 14-3-3theta's effects on LRRK2 kinase activity.

27 eneralizable insights into the regulation of kinase activity.

28 presence of neuronal activity but not on its kinase activity.

29 e binding to Cdk9 and thereby to inhibit its kinase activity.

30 ing an increase in mitogen-activated protein kinase activity.

31 link MST1/2 with MARK3, and inhibits MST1/2 kinase activity.

32 es and, unexpectedly, is essential for DLK's kinase activity.

33 ls but a sustained, significant reduction in kinase activity.

34 entire kinase domain, p50 N-LOK displays no kinase activity.

35 acting upstream of the ATM and Rad3-related kinase activity.

36 G2019S LRRK2 mutation that upregulates LRRK2 kinase activity.

37 ation of alpha-actinin by IP6K1 requires its kinase activity.

38 ral unrelated PAMPs rapidly induced ASKalpha kinase activity.

39 or cyclin E-CDK2, leading to increased CDK2 kinase activity.

40 ng insight for strategies to better regulate kinase activity.

41 kinase, and both similarly activated CheA's kinase activity.

42 ng and thereby inhibits activation of PDGFRA kinase activity.

43 different signaling network, despite similar kinase activity.

44 the TSC1 or TSC2 genes, which regulate mTOR kinase activity.

45 ans-Golgi network and greatly stimulates its kinase activity.

46 feedback loop in CD4(+) T cells and promotes kinase activity.

47 PK by suppressing Y kinase and enhancing S/T kinase activity.

48 the guanylate cyclase, in turn inhibits BRI1 kinase activity.

49 NDK5 or a mutated NDK5 lacking the canonical kinase activity.

50 loop Ser(359) phosphorylation, and defective kinase activity.

51 n of PKC to the cell membrane, and activates kinase activity.

52 osphorylation of EMS1 by SERK1 enhances EMS1 kinase activity.

53 d cytokine production independently of RIPK1 kinase activity.

54 f which differentially affect 3-kinase and 6-kinase activities.

55 h regulate autophagy induction through their kinase activities.

56 linositol 4,5-bisphosphate (PtdIns(4,5)P2) 3-kinase activities.

57 nding (20.9%), hydrolase activities (10.6%), kinase activities (7%), and catalytic activity (5.6%).

58 bsence of PIAS3, ATR fails to display normal kinase activity after DNA damage, which accompanies with

59 indicative of evolutionary optimization of 3-kinase activities against both substrates.

60 MAN2A1-FER had tyrosine kinase activity almost 4-fold higher than that of wild-t

61 Moreover, we found that inhibition of RIPK1 kinase activity also enhanced parasite replication in th

62 HNO enhanced WT kinase activity, an effect significantly attenuated in i

63 coupling characteristics between biochemical kinase activities and structural FA within single FAs.

64 K5 on lysine 184, which is necessary for its kinase activity and AP-1 activation.

65 d leads to a decrease in PIP5Klgammas' lipid kinase activity and binding affinity for Talin.

66 n Hop1 and Rec114 does not, implicating Tel1 kinase activity and clarifying roles of Tel1 phosphoryla

67 nted the effects of TGF-beta on RhoA and Rho-kinase activity and contraction, respectively.

68 r native microenvironment when levels of PI3-kinase activity and DE-cadherin are elevated in NBs.

69 due D285, which directly abolished its lipid kinase activity and dramatically altered cell invasion p

70 increased central nuclei, elevated creatine kinase activity and endomysial fibrosis.

71 ibited strong inhibitory effects toward EGFR kinase activity and excellent inhibition of cell growth

72 8 during autophagy initiation, we found that kinase activity and gene expression of ULK1 are increase

73 highlights the importance of this region for kinase activity and inhibitor efficacy.

74 Sin1 translation, and thus suppressed mTORC2 kinase activity and invasion in colon tumor cells.

75 These data demonstrate that both Pak2 kinase activity and its interaction with beta-Pix are es

76 her, these data demonstrate that the protein kinase activity and levels of PIM1 can be regulated by a

77 wnregulation of transcription depends on ATM kinase activity and on the distance from the DSB.

78 nr4 relocalization by low iron requires Dun1 kinase activity and phosphorylation site Thr-380 in the

79 a positive relationship between phytochrome kinase activity and photoresponses in plants.

80 coordinate with IL-2-independent networks of kinase activity and provide a resource toward the furthe

81 clinical copper chelator TTM inhibits MEK1/2 kinase activity and reduces BRAF(V600E)-driven tumorigen

82 1 mutations are truncations that disrupt its kinase activity and remove its C-terminal domain (CTD).

83 e associated-FAM20C mutants prevented FAM20C kinase activity and secretion, overexpression of the cat

84 explore the effect of calmodulin on creatine kinase activity and show that it is increased by the int

85 during amino acid starvation, limiting Gcn2p kinase activity and suppressing Gcn4p-dependent gene exp

86 rein we show that both proteins have acetate kinase activity and that EutQ is required during anoxic

87 2 by direct interaction with CIPK23 requires kinase activity and the calcineurin B-like binding prote

88 amically modulated in wild-type cells by TOR kinase activity and the presence of acetate.

89 a target gene, an important regulator of Rho-kinase activity and therefore a potential therapeutic ta

90 ence during latency-like conditions required kinase activity and thioredoxin motifs of PknG and is me

91 ited to active integrins, which enhances its kinase activity and triggers downstream signaling like a

92 Src tyrosine kinase activity and tyrosine phosphorylation of VE-cadhe

93 nd chromatin through genomic footprinting of kinase activity and unbiased identification of prominent

94 Z) genome recognizes the lack of sphingosine kinase activity and up-regulates cers2b as a salvage pat

95 th the FAK FERM-kinase linker and induce FAK kinase activity and Y397 phosphorylation.

96 When levels of PI3-kinase activity and/or DE-Cadherin are reduced in NBs, N

97 K2 has guanosine triphosphatase (GTPase) and kinase activities, and mutations in LRRK2 are the major

98 ur initiation, a phenomenon mediated by Craf kinase activity, and effectively accelerates tumour prog

99 All mutations increased kinase activity, and pleckstrin homology domain mutants

100 Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are do

101 This regulation depended on Plk1 kinase activity, and the administration of small-molecul

102 e the authors demonstrate that Bub1 and Mps1 kinase activities are required for Sgo2 localisation to

103 icle, we demonstrate that CK2 expression and kinase activity are induced upon CD4(+) T cell activatio

104 In mouse infection, both PGAM5 and RIPK1 kinase activity are required for IL-1beta expression in

105 point mutation at amino acid 1648, silencing kinase activity, are not.

106 s genetic validation for inhibition of LRRK2 kinase activity as a potential means of affecting diseas

107 n Tec-deficient B cells was dependent on Btk kinase activity, as ibrutinib treatment restored pS6 to

108 inhibitor dasatinib, which antagonizes TNK2 kinase activity, as well as novel TNK2 inhibitors, XMD8-

109 Using co-immunoprecipitation and CDK kinase activity assays, we found that PIN1 binds the pho

110 ve polymerase chain reaction and sphingosine kinase activity assays.

111 e phosphorylation, suggesting increased ABL1 kinase activities associated with both the p.Tyr245Cys a

112 (AZD2171) is a potent inhibitor of tyrosine kinase activity associated with vascular endothelial gro

113 multiplexed measurements of the dynamics of kinase activity at a single-cell level.

114 tedly, autophosphorylated CPK28 had enhanced kinase activity at physiological concentrations of Ca(2+

115 GSK690693 potently inhibited PrkA kinase activity biochemically and exhibited significant

116 consistent with DM leading to changes in tau-kinase activity broadly within the brain.

117 NA-AAF in a manner largely dependent on ATR kinase activity but independent of the essential nucleot

118 ed that Thr1160 phosphorylation impairs INSR kinase activity by destabilizing the active configuratio

119 PLK3, and PLK4, as well as inhibition of PLK kinase activity by four different compounds, leads to re

120 amplified by a 2-fold activation of 5-InsP7 kinase activity by Pi within the 0-5 mm range.

121 conclude that the EphA2 SAM domain inhibits kinase activity by reducing receptor oligomerization.

122 In turn, inhibition of PI3K kinase activity by the PI3K-speicfic inhibitor LY294002

123 Unfortunately, chemical inhibitors of PERK's kinase activity cause on-target side effects that have p

124 -Srcs have altered substrate specificity and kinase activity compared to C-Src.

125 these heterodimers have much-reduced protein kinase activity compared to Mst1 or Mst2 homodimers.

126 We propose that LKB1 kinase activity controls membrane dynamics through FAK s

127 ctive inhibitor of IRAK4, we show that IRAK4 kinase activity controls the activation of interferon re

128 We speculate that SMG-1 kinase activity could be activated following DNA damage

129 latable S561A mutation or inhibition of Par1 kinase activity decreases SH3-GK interaction, causing PS

130 t LRRK2 G2019S-induced mtDNA damage is LRRK2 kinase activity dependent, uncovering a novel pathologic

131 turn suppresses the SIAH2 protein level in a kinase activity-dependent manner.

132 Lack of RIPK1 kinase activity did not inhibit DEN-induced liver tumor

133 n PERK or ATF4 expression or inhibiting PERK kinase activity diminished L. amazonensis infection.

134 NPM-ALK-deregulated kinase activity drives several pathways that support mal

135 Deregulated AKT kinase activity due to PTEN deficiency in cancer cells c

136 Conversely, allosteric stimulation of ABL1 kinase activity enhanced the antileukemia effect of ABL1

137 d binding, tyrosine autophosphorylation, and kinase activity; EphA2 "noncanonical" signaling involves

138 served Las1-dependent activation of the Grc3 kinase activity exclusively toward single-stranded RNA.

139 ylatable mutant IKBKE-Y153F/Y179-F that lost kinase activity failed to activate AKT and inhibited EGF

140 he structural basis of substrate-binding and kinase activity for diverse substrates phosphorylated by

141 , but not Paxx(-/-) cells require ATM/DNA-PK kinase activity for end-ligation.

142 nzyme priming or the functional relevance of kinase activity for excessive alcohol intake.

143 ill provide valuable data regarding aberrant kinase activity from small samples of clinical interest.

144 on and transport by cortical flow to control kinase activity gradients and polarity in the C. elegans

145 While how recurring point mutations affect kinase activity has been described, the effect of in-fra

146 However, the function of their kinase activity has been enigmatic, and only recently ha

147 ta correlating FAD redox chemistry with CheA kinase activity have been lacking.

148 ion at both T308 and S473, and inhibited Akt kinase activity (IC50 = 6 microM) and downstream signali

149 PKR eIF2alpha binding site and blocking PKR kinase activity.IMPORTANCE The antiviral kinase PKR play

150 present the primary Ca(2+)-dependent protein kinase activities in plant systems.

151 ors to simultaneously measure PKA and ERK1&2 kinase activities in the same cellular localization by u

152 action, we achieved multiplexed detection of kinase activity in a modular fashion without requiring a

153 uced contraction, RhoA translocation and Rho-kinase activity in airway smooth muscle largely via ARHG

154 n levels, resulting in the inhibition of Akt kinase activity in both types of renal cancer cells.

155 me-dependent increase in MLCK expression and kinase activity in Caco-2 monolayers.

156 ed cell death-independent requirement of RIP kinase activity in coordinating neuroinflammation, restr

157 t (the C/N ratio) is used as a proxy for the kinase activity in living, single cells.

158 FERONIA protein kinase activity in nanodiscs was higher than that of sol

159 naling in zebrafish, we discovered that mTOR kinase activity in oligodendrocytes requires cholesterol

160 tion by demonstrating severely impaired INSR kinase activity in phosphomimetic T1160E mutants.

161 and functional roles of putative phytochrome kinase activity in plant light signalling are largely un

162 rial shear rate, indicating a role for Vps34 kinase activity in platelet activation, independent from

163 Tools to evaluate oncogenic kinase activity in small clinical samples have the power

164 ting the pathological increase of calmodulin kinase activity in treated mice.

165 tantly, the new monobodies inhibited Bcr-Abl kinase activity in vitro and in cells, and they potently

166 s that contact the guanine nucleobase efface kinase activity in vitro and Trl1 function in vivo.

167 lly, SUMOylated PIM1 showed enhanced protein kinase activity in vitro.

168 n-proteasome pathway and inhibition of MARK4 kinase activity in vitro.

169 covalently and specifically inactivate Kin28 kinase activity in vivo.

170 ll survival in a dose-dependent but pyruvate kinase activity-independent manner.

171 that sustained extracellular signal-related kinase activity induced by BRAFV600E inhibits C-C motif

172 of Met expression, but not inhibition of Met kinase activity, induced apoptosis by reducing integrin

173 Therapeutic inhibition of tyrosine kinase activity induces a retraction of these projection

174 to occur to benchmark and compare different kinase activity inference strategies: Z-test, Kolmogorov

175 ore, we provide evidence that mTOR and CHEK1 kinase activity influence NFAT's transcriptional potency

176 Our data suggest that IreK, through its kinase activity, inhibits the actions of these proteins.

177 ed fluorescent activity sensors that convert kinase activity into a nucleocytoplasmic shuttling equil

178 nd mechanism for potentiation of PtdIns 4-OH kinase activity is a broadly conserved feature of plant

179 his study, we demonstrate that increased Src kinase activity is associated with high-fat diet-acceler

180 ypes are not observed in cells in which Rps6 kinase activity is compromised.

181 n how mTORC1 selects its substrates, how its kinase activity is controlled, and how it is activated b

182 in the active, open conformation at CAs, its kinase activity is dispensable for ciliogenesis and cili

183 Stringent regulation of tyrosine kinase activity is essential for normal cellular functio

184 asma membrane by PRK4 and PRK5, and that PRK kinase activity is important in facilitating its interac

185 an unphosphorylatable mutant of ATG13, ULK1 kinase activity is more potent, and amino acid starvatio

186 ismal impact of systemic inhibition of Vps34 kinase activity is not completely understood.

187 In contrast to TOR complex 1 (TORC1), TORC2 kinase activity is not inhibited by the macrolide rapamy

188 Little is known about how DAG kinase activity is regulated by posttranslational modifi

189 ITK kinase activity is required for mouse and human Tr1 cell

190 Thus, both mTORC1 and mTORC2 kinase activity is tightly controlled in cells.

191 ase target sites can be used to infer when a kinase activity is under regulation.

192 stically, while they have no clear effect on kinase activity, L290P/V mutations enhance ERK3's cytopl

193 ion ceases, because growth factor and/or PI3-kinase activity levels become attenuated.

194 This short-lived burst in kinase activity links development with maternal mRNA tra

195 Mps1 and Bub1 kinase activities localise Sgo2 in meiosis I preferentia

196 These results suggest that FGFR3 kinase activity may regulate the PV reproductive program

197 extracellular signal input and intracellular kinase activity modulation in Staphylococcus aureus.

198 of prostate cancer, LO harbor sustained AKT1 kinase activity, nominating them as active signaling pla

199 Notably, this regulation requires kinase activities of both RIPK1 and RIPK3, but not the n

200 Here, we report that kinase activities of Bub1 and Mps1 are required for Sgo2

201 ial reorganization requires endocytosis, the kinase activities of MEK-ERK and CK2, and the presence o

202 , H917A abolished both the lipid and protein kinase activities of PI3Kalpha.

203 the basis of diverse binding affinities and kinase activities of PKCalpha for 14 substrates with var

204 Necroptosis is mediated by the kinase activities of receptor interacting protein kinase

205 s is necroptosis, which is transduced by the kinase activities of receptor interacting protein kinase

206 ine kinase inhibitors (TKIs) that target the kinase activity of BCR-ABL1 have transformed CML from a

207 OP1 stimulation is strongly dependent on the kinase activity of BRD4, a protein that phosphorylates S

208 vating kinase subcomplex, which includes the kinase activity of CDK7 as well as the cyclin H and MAT1

209 I, and this binding upregulates the tyrosine kinase activity of EGFRvIII and activates the RAS/RAF/ME

210 Peptide kinase activity of fully dephosphorylated CPK28 was Ca(2

211 In epithelial cells, the kinase activity of IRE1alpha was required for the induct

212 resistance in E. faecalis, dependent on the kinase activity of IreK.

213 The aberrant kinase activity of Kit(mut) prevents its export from the

214 e to the TORKi was unusual in that intrinsic kinase activity of mTOR was increased, rather than a dir

215 Moreover, CaM is capable of stimulating the kinase activity of mTORC1 in a calcium-dependent manner

216 Inhibition of TNFAIP3/A20 promotes kinase activity of p38 mitogen-activated protein kinase

217 xperimental validation demonstrated that the kinase activity of p38(MAPK) determines signal amplitude

218 The kinase activity of PERK and ribonuclease (RNase) of IRE1

219 ing the acetyllysine binding of BRD4 and the kinase activity of PI3K.

220 iscovery of small molecules that amplify the kinase activity of PINK1.

221 Yersinia-induced apoptosis requires the kinase activity of receptor-interacting protein kinase 1

222 ffect of RIPK1 on PGRN is independent of the kinase activity of RIPK1 and occurs through a novel sign

223 rylated SOS2 in vitro, resulting in elevated kinase activity of SOS2.

224 rans by the donor; this process requires the kinase activity of the donor but not that of the receive

225 ne application promotes or inhibits receptor kinase activity of the ethylene receptors.

226 binding significantly inhibits the specific kinase activity of the membrane-bound PI3Kalpha molecule

227 ed autophagy initiation in which the protein kinase activity of the metabolic enzyme PGK1 plays an in

228 Here, we show that the kinase activity of the serine/threonine kinase encoded b

229 The DNA motifs and CTP-dependent riboflavin kinase activity of two RbkR proteins were experimentally

230 kt activator, was dependent upon the Ser/Thr kinase activity of Us3.

231 ffector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosom

232 findings suggest a regulatory role of TRPM7 kinase activity on intracellular Ca(2+) and extracellula

233 n protein fluorescence dynamics to translate kinase activities or protein-protein interactions into c

234 ass of BRAF mutants-those that have impaired kinase activity or are kinase-dead.

235 Met promotes cell survival, we inhibited Met kinase activity or blocked its expression with RNA inter

236 or pharmacologic inhibition of EGFR tyrosine kinase activity or downstream MEK activity attenuated th

237 the Cys(43) oxidation had no effect on basal kinase activity or Km and Vmax values; however, PKGIalph

238 esting that core signaling complexes produce kinase activity over a range of receptor conformations a

239 progenitor cell divisions by regulating Polo kinase activity, play an additional, mutually redundant

240 athy and suggesting that unbalanced PtdIns 3-kinase activity plays a critical role in the pathologica

241 gh eIF2alpha phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistan

242 nhibition of Cdk1 activity, but not Aurora A kinase activity, prevents the translation of Mos or Ccnb

243 Kinase activity profiling revealed that GD1a activated a

244 adic ALS and C9ORF72 ALS, and blocking HIPK2 kinase activity protects motor neurons from TDP-43 cytot

245 identify an innovative mechanism to control kinase activity, providing insight for strategies to bet

246 ction of intracellular Ca(2+) and calmodulin kinase activity, ranolazine prevented the development of

247 ested that changes in the total level of CDK kinase activity, rather than substrate specificity, driv

248 rectly on their regulators by inhibiting Akt kinase activities, reducing NADPH oxidase 2 activation,

249 uggest an intramolecular mechanism for LRRK2 kinase activity regulation.

250 rimentally using a modified version of the A kinase activity reporter (AKAR) protein kinase A (PKA) b

251 n of phosphatidylinositol 3-kinase (PtdIns 3-kinase) activity rescues the Ca(2+) release defects in i

252 The kinase activity responses to receptor ligand occupancy c

253 of EphA4 and specifically ablation of EphA4 kinase activity resulted in misaligned neuroblasts and d

254 Chemical inhibition of LRRK2 kinase activity resulted in the stimulation of macroauto

255 We demonstrate that the enhanced kinase activity resulting from the most frequent G2019S

256 e p.E80K mutation abolished serine/threonine kinase activity, resulting in altered ICK subcellular an

257 rane dynamics through FAK since loss of LKB1 kinase activity results in morphologically defective nas

258 f ILK1 mutants impaired in the expression or kinase activity revealed that ILK1 contributes to plant

259 The simultaneous recording of PKA and ERK1&2 kinase activities reveals concomitant EGF-mediated activ

260 ffering new quantitative connections between kinase activity, RLC phosphorylation, and SF viscoelasti

261 sical tools to explore relationships between kinase activity, RLC phosphorylation, SF localization, a

262 where coordination of LKB1 farnesylation and kinase activity serve as a multi-step mechanism to coord

263 ATR kinase activity slows replication forks and prevents ori

264 pecific approaches to measure and manipulate kinase activity specifically within AgRP neurons, we est

265 Kinase activity stemmed from conformational flexibility

266 ase-modifying treatment in PD biomarkers for kinase activity, target engagement and kinase inhibition

267 ber on PV interneurons and displayed greater kinase activity than the minor variant, suggesting that

268 nge in phosphorylation motif frequencies and kinase activities that coincides with the whole-genome d

269 potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity ag

270 -hydroxyl of phosphoinositides and a protein-kinase activity that includes autophosphorylation.

271 PI3Ks have dual kinase specificity: a lipid kinase activity that phosphorylates the 3'-hydroxyl of p

272 AML cells have increased cytidine nucleoside kinase activity that regulates mtDNA biogenesis and can

273 ing cells showed a 7.7-fold reduction in DAG kinase activity; the reduced enzyme activity could be in

274 Consistent with mitosis-independent kinase activity, this pattern was preserved in ESCs trea

275 LPK2, both lacking extracellular domains and kinase activity, through mRNA degradation to promote imm

276 stimulated Rac and increased focal adhesion kinase activity to enhance cell tension by maintaining c

277 chemical evidence that mRNA-cap inhibits PKA kinase activity to promote Hh signaling.

278 Linking levels of PI3-kinase activity to the strength of adhesive attachment c

279 of FRET-based kinase sensors for monitoring kinase activity under two-photon fluorescence lifetime i

280 evels of PINK1 protein and decreased initial kinase activity upon mitochondrial damage, stress-respon

281 s from an affected individual showed loss of kinase activity upon stimulation with fibroblast growth

282 pid metabolism and mitogen-activated protein kinase activity upregulated in women exposed to IP-relat

283 increasing WNK4 levels, also modulates WNK4 kinase activity via phosphorylation of sites outside the

284 PI3Kalpha, yielding a large increase in net kinase activity via the membrane recruitment mechanism.

285 othelial ERK (extracellular signal-regulated kinase) activity via adrenergic alpha1 and alpha2 recept

286 IRE1alpha kinase activity was also important for the development o

287 Akt kinase activity was higher in HCV mice than in WT mice,

288 Kinase activity was monitored in cells transfected with

289 Although ErbB4 kinase activity was not necessary for the SUMOylation, t

290 Moreover, cGK (cGMP-dependent protein kinase) activity was downregulated in Npr2(+/-) valves,

291 to Leishmania However, PGAM5, but not RIPK1 kinase activity, was directly responsible for Leishmania

292 oxicity is likely mediated through increased kinase activity, we examined 14-3-3theta's effects on LR

293 n protection, whereas oocytes devoid of Bub1 kinase activity, which cannot phosphorylate H2A at T121,

294 scle fibers, Gadd45a increases MEKK4 protein kinase activity, which is both sufficient to induce skel

295 Through the targeted disruption of RIPK1 kinase activity, which selectively disrupts RIPK1-depend

296 he transient increase of EGF-mediated ERK1&2 kinase activity while reinforcing PKA activation.

297 lmintic drug, could selectively inhibit TNIK kinase activity with a dissociation constant Kd = ~1 muM

298 unctioned like WT holoenzyme in terms of its kinase activity with an exogenous substrate, and for end

299 Although H936A inactivated the lipid kinase activity without affecting autophosphorylation, H

300 on to alanine (A) resulted in elimination of kinase activity without affecting the overall structure