ライフサイエンスコーパス: kinase complex

1 that mediates the degradation of the IkappaB kinase complex.

2 ppaB (NF-kappaB) is activated by the IkappaB kinase complex.

3 rging on the Autophagy-Related1 (ATG1)/ATG13 kinase complex.

4 A, to activation of the ATR-ATRIP checkpoint kinase complex.

5 and Ku80 components in DNA-dependent protein kinase complex.

6 R-1 activation to stimulation of the IkappaB kinase complex.

7 ch activates the TAK1 (also known as MAP3K7) kinase complex.

8 ation of the Ret/GFRalpha3 receptor tyrosine kinase complex.

9 activity regulate a cyclin/cyclin-dependent kinase complex.

10 gamma, the regulatory subunit of the IkappaB kinase complex.

11 plex, which in turn activates the Warts/Mats kinase complex.

12 ly suppressing the activation of the IkappaB kinase complex.

13 ubstrates compared with another Pho85-cyclin kinase complex.

14 4 signal pathway was proximal to the IkappaB kinase complex.

15 IKKalpha, one of the subunits of the IkappaB kinase complex.

16 gamma, encoding the gamma subunit of the AMP Kinase complex.

17 nd the IKKalpha/beta subunits of the IkappaB kinase complex.

18 This condensation depends on the aurora B kinase complex.

19 ion of the kinase and cyclin subunits of the kinase complex.

20 tion of the IRS-1/p85 phosphatidylinositol 3-kinase complex.

21 US28 stimulates the production of a FAK.Src kinase complex.

22 kinase stimulation in the assembled receptor-kinase complex.

23 between Bcl10 and activation of the IkappaB kinase complex.

24 of an open, uninhibited conformation of the kinase complex.

25 ich is the regulatory subunit of the IkappaB kinase complex.

26 g in loss of activity and disassembly of the kinase complex.

27 e and subsequently to regulation of the cdk4 kinase complex.

28 is the catalytic subunit, of the Rad3/Rad26 kinase complex.

29 on and degradation of IkappaB by the IkappaB kinase complex.

30 the action of the Atg14-containing Vps34 PI3 kinase complex.

31 one signaling pathway regulated by the TAK1 kinase complex.

32 s do not inhibit or associate with the Hippo kinase complex.

33 microscopy structure of the Hsp90-Cdc37-Cdk4 kinase complex.

34 ved the activation of the BECN1/PIK3C3 lipid kinase complex.

35 osphatidylinositol 3-kinase complex I) lipid kinase complex.

36 parasites by interference with the virulent kinase complex.

37 promotes Wts phosphorylation by the Hpo-Sav kinase complex.

38 f the exocyst by a specific cyclin-dependent kinase complex.

39 subunits actually mediate(s) docking of this kinase complex.

40 ibitors, a process controlled by the IkappaB kinase complex.

41 oteins), and mitogen-activated protein (MAP) kinase complexes.

42 nding of cell cycle inhibitor p27Kip1 to the kinase complexes.

43 nal connection between the Apg1 and PtdIns 3-kinase complexes.

44 ough inhibition of target of rapamycin (TOR) kinase complex 1 (TORC1) activity.

45 The rapamycin-sensitive Tor kinase complex 1 (TORC1) has a major role in regulating

46 In nutrient-rich conditions, Tor kinase complex 1 (TORC1) is activated to inhibit autopha

47 Target of rapamycin kinase complex 1 (TORC1) regulates Pol III activity, and

48 The rapamycin-sensitive Tor kinase complex 1 is a major regulator of autophagy.

49 We report here that mTOR kinase complexes 1 and 2 (mTORC1 and mTORC2) are essenti

50 permeable peptide inhibitor of the I kappa B-kinase complex, a crucial component of signal transducti

51 tivated through phosphorylation by the TORC1 kinase complex, a sensor of nutrient availability.

52 or-associated kinase, IkappaB-alpha, IkappaB kinase complex-alpha/beta, and phospholipase-gamma1 and

53 The Aurora kinase complex, also called the chromosomal passenger co

54 osphatidylethanolamine, as well as a protein kinase complex and a phosphatidylinositol 3-kinase compl

55 ere associated with the reduction of IkappaB kinase complex and c-Jun NH(2)-terminal kinase activatio

56 tment resulted in degradation of the IkappaB kinase complex and inhibition of NF-kappaB through stabi

57 of the Ku70, Ku80, and DNA-dependent protein kinase complex and is conveyed to the recipient cell by

58 ough the catalytic components of the IkappaB kinase complex and leads to IkappaB phosphorylation, deg

59 le inhibitor 2c blocks assembly of the multi-kinase complex and represses HIV-1-mediated MHC-I down-r

60 paB signaling via its effects on the IkappaB kinase complex and resulting in reduced IL2 gene express

61 Structural models of the Smad3/SARA/receptor kinase complex and Smad3/Ski complex provide insights in

62 ed by a rapid phosphorylation of the IkappaB kinase complex and subsequent degradation of the NF-kapp

63 Chiffon to form a functional Dbf4-dependent kinase complex and that Cdc7 is necessary for DNA replic

64 , absent from previous structures, a protein kinase complex and the Mediator-activator interaction re

65 -like autophagy activating kinase 1) protein kinase complex and the PI3KC3-C1 (class III phosphatidyl

66 hrough the inactivation of the Cdk1-cyclin B kinase complex and the reversal of its phosphorylation e

67 so requires the Uvrag-containing Vps34 lipid kinase complex and the v-ATPase proton pump, whereas Atg

68 rotein signaling complexes, such as the ULK1 kinase complex and the Vps34 lipid kinase complex, which

69 -cell lymphomas: inhibition of the Jak1/Jak3 kinase complex and, given the known strong immunostimula

70 ically its role in the activation of protein kinase complexes and in coordination of cell survival an

71 chains act as scaffolds to assemble protein kinase complexes and mediate their activation through pr

72 IFREDA was used in eight protein kinase complexes and was able to find the correct ligand

73 p21 can interact both with cyclin-dependent kinase complexes and with proliferating cell nuclear ant

74 L)-VPS34 (a class III phosphatidylinositol 3-kinase) complex and its product phosphatidylinositol 3-p

75 [ataxia-telangiectasia mutated]-Rad3-related kinase) complex and the Rad9-Hus1-Rad1 (9-1-1) clamp.

76 Balpha (IkappaBalpha), activation of IkappaB kinase complex, and c-Jun NH(2)-terminal kinase and, sub

77 Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.

78 composed of NEMO, a component of the IkappaB kinase complex, and the death domain of RIP (NEMO-DD) ca

79 n ligase complex, components of the PtdIns 3-kinase complex, and the ESCRT machinery.

80 purified proteins, including TRAF6, the TAK1 kinase complex, and Ub-conjugating enzyme complex Ubc13-

81 roviding viral decoy substrates for cellular kinase complexes, and through direct blocking of the IFN

82 mplexes comprising a Rac1.PAK (p21-activated kinase) complex, and 11 S and 16 S Rac1 complexes.

83 kinase complex and a phosphatidylinositol 3-kinase complex are also required for macroautophagy in y

84 c;2 and cyct1;5 mutants, indicating that the kinase complexes are important for transcription from th

85 ycles that regulate the activity of receptor-kinase complexes are ultrasensitive because they operate

86 These results establish Arabidopsis CDKC kinase complexes as important host targets of CaMV for t

87 he cyclin E/cyclin-dependent kinase 2 (CDK2) kinase complex, as a key coactivator to enhance histone

88 ranscription at a point distal to the Ikappa kinase complex, as only ectopic expression of the NFkapp

89 tization occurs well upstream of the IkappaB kinase complex, as protein kinase C translocation to the

90 F-regulated scaffold that modulates receptor kinase complex assembly.

91 However, in the absence of S-phase kinases complex assembly is inhibited, which is unexpect

92 20 and a corresponding reduction in ikappaB kinase complex associated protein (IKAP) levels.

93 ponding reduction of the inhibitor of kappaB kinase complex-associated protein (IKAP), also known as

94 of its encoded protein, inhibitor of kappaB kinase complex-associated protein (IKAP).

95 a mutation in the gene inhibitor of kappa B kinase complex-associated protein (IKBKAP).

96 dysautonomia patients with IKBKAP (I-kappa-B kinase complex-associated protein) mutation compared to

97 s point mutation in IKBKAP, encoding IkappaB kinase complex-associated protein.

98 machinery immediately downstream of the Atg1 kinase complex at phagophore assembly sites.

99 s the mammalian target of rapamycin (mTORC1) kinase complex at the lysosomal surface.

100 g1/Unc-51-like autophagy activating kinase 1 kinase complex, autophagic receptor proteins, and mammal

101 The Ctk1 kinase complex binds RNA in vitro, consistent with direc

102 ompromises the recruitment of Cdc37 to Hsp90-kinase complexes but has only modest effects on its basa

103 unction for activation of the IKK kinase (or kinase complex), but none form a stable complex with IKK

104 mplex), linked to the inhibitor of NF-kappaB kinase complex, but signal transduction is not fully und

105 mitment to mitosis is regulated by a protein kinase complex called MPF.

106 ccurs via sequestration of the active P-TEFb kinase complex (CDK 9 and Cyclin T1/T2a/b or K) that is

107 Another Ser2 kinase complex, CDK-12/cyclin K, which requires upstream

108 nance energy transfer that active LKB1/STRAD kinase complex colocalizes with E-cadherin at AJs.

109 two phosphatidylinositol 3-kinase (PtdIns 3-kinase) complexes: complex I is required for autophagy,

110 d chemical and mechanical insults activate a kinase complex composed of IkappaB kinase beta (IKK-beta

111 ally upstream of the noncanonical regulatory kinase complex composed of NIK.IKKalpha subunits.

112 ation showed altered interactions with Hsp90-kinase complexes consistent with compromised Cdc37 modul

113 on of NF-kappaB and IKK requires an upstream kinase complex consisting of TAK1 and adaptor proteins s

114 ion factor NF-kappaB is activated by the IKK kinase complex containing two kinases (IKKalpha and IKKb

115 The Snf1 kinase complexes containing Gal83 or Sip2 as the beta su

116 ways by functioning as a scaffold to recruit kinase complexes containing ubiquitin-binding domains.

117 cyclin-dependent kinase (CDK) 2-cyclin E, a kinase complex critical for the initiation of centrosome

118 with Ctk2 and Ctk3 to form an active protein kinase complex, CTDK-I.

119 ophila melanogaster cyclin-dependent protein kinase complex CycD/Cdk4 stimulates both cell cycle prog

120 The Drosophila cyclin-dependent protein kinase complex Cyclin D/Cdk4 induces cell growth (accumu

121 -docking site on Nud1, to which the effector kinase complex Dbf2-Mob1 bound through a phosphoserine-t

122 resses RIP3-RIP1 (also known as RIPK3-RIPK1) kinase complex-dependent necroptosis that follows death

123 egulation by Hippo and to associate with the kinase complex directly correlate with their capacity to

124 us was associated with increased DNA protein kinase complex (DNA-PK) activity.

125 ase beta, a catalytic subunit of the IkappaB kinase complex essential for NF-kappaB activation, fails

126 Inhibition of the IkappaB kinase complex essentially ablated all cytokine inductio

127 ed transient insolubilization of the IkappaB kinase complex following its dissociation from Hsp90 rep

128 We also observed stable STAT3.Src family kinase complex formation in this system.

129 ity, which occurred by inhibition of IkappaB kinase complex formation rather than by a direct effect

130 y, we showed that Hh signaling inhibits Cos2-kinase complex formation.

131 r, c-Src, and P85 (regulatory subunit of PI3-kinase) complex formation.

132 18BIOder preferentially inhibits this novel kinase complex from infected cells at nanomolar concentr

133 ally available crystal structures of protein kinases complexes have motivated structural bioinformati

134 entration of ATP above 1.2 mM and makes this kinase complex highly sensitive to ATP depletion.

135 ssociate with C9ORF72 or with a C9ORF72-ULK1 kinase complex holo-assembly, which function in maturati

136 ct myotubularin binding to the type III PI 3-kinase complex hVps34/hVps15 leads to phosphatase inacti

137 The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) is central to autophagy ini

138 The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) is required for the initiat

139 The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early aut

140 PI3KC3-C1 (class III phosphatidylinositol 3-kinase complex I) lipid kinase complex.

141 ed protein kinases Atg1, target of rapamycin kinase complex I, and protein kinase A (PKA) regulate au

142 (PI(3)P) produced by the phosphoinositide 3-kinase complex II.

143 activation of NF-kappaB requires an upstream kinase complex (IkappaB-kinase; IKK) composed of two cat

144 the NF-kappaB-activating inhibitor of kappaB kinase complex IKK-alpha/beta and active transcription f

145 or is demonstrated to signal through IkappaB kinase complex (IKK) 2 > IkappaB > nuclear factor kappaB

146 ation and degradation, inhibition of IkappaB kinase complex (IKK) activation, suppression of p65 phos

147 ay components functioned upstream of IkappaB kinase complex (IKK) activation.

148 Balpha (IkappaBalpha), activation of IkappaB kinase complex (IKK) and c-Jun-NH2-terminal kinase (JNK)

149 , which subsequently activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP)

150 s required for the activation of the IkappaB kinase complex (IKK) by inflammatory stimuli such as tum

151 Inhibition of the IkappaB kinase complex (IKK) has been implicated in the therapy

152 hat both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the phosphorylat

153 The IkappaB kinase complex (IKK) is a key regulator of immune respon

154 The IkappaB kinase complex (IKK) is central to the activation of NF-

155 A multisubunit IkappaB kinase complex (IKK) phosphorylates IkappaB proteins and

156 The IkappaB kinase complex (IKK) that phosphorylates IkappaB contain

157 genic mice, mutant Htt activates the IkappaB kinase complex (IKK), a key regulator of NF-kappaB.

158 1, TNFR2, NF-kappaB-inducing kinase, IkappaB kinase complex (IKK), and the p65 subunit of NF-kappaB.

159 panied by enhanced activation of the IkappaB kinase complex (IKK), which is responsible for targeting

160 of NF-kappaBeta (IkappaBeta), and IkappaBeta kinase complex (IKK).

161 of NEMO, a regulatory subunit of the IkappaB kinase complex (IKK).

162 actor-kappaB (NF-kappaB) through the IkappaB kinase complex (IKK).

163 hibitory I kappa B proteins by the I kappa B kinase complex (IKK).

164 The IkappaB kinase complex (IKK)/NF-kappaB and JNK/AP-1 pathways are

165 ses and is tightly controlled by the IkappaB kinase complex (IKK-alpha/beta/gamma).

166 function by preventing the activation of the kinase complex, IKK, which is responsible for phosphoryl

167 and activation of a key NF-kappaB activating kinase complex, IKK.

168 the gamma subunit of the inhibitor of kappaB kinase complex (IKKgamma; commonly referred to as the NF

169 Surprisingly, the IkappaB kinase (IKK) kinase complex, implicated in proteasome-mediated degrad

170 The structure captures the kinase-kinase complex in a precatalytic state where the activat

171 Here, we describe a role for the Hippo (Hpo) kinase complex in promoting Partner of Inscuteable (Pins

172 he involvement of a GP Ibalpha/14-3-3xi/PI-3 kinase complex in regulating thrombopoietin-mediated res

173 and degradation upon activation of the TORC1 kinase complex in response to an increase in internal am

174 and the formation of a novel focal adhesion kinase complex in response to ErbB2 activation in mammar

175 defined an essential role for the Dbf4-Cdc7 kinase complex in the initiation of DNA replication pres

176 ells only, by sequestering a cytosolic Hippo kinase complex in which LATS kinase is inhibited.

177 raction, binds LIT-1 and thereby generates a kinase complex in which LIT-1 molecules are situated in

178 , exists in two essential, yet distinct, TOR kinase complexes in the budding yeast Saccharomyces cere

179 mately 1 pM, compared with 30 nM for the CaM-kinase complex, indicating that activation of autoinhibi

180 ession and increased cyclin/cyclin-dependent kinase complex inhibitor p27kipl expression.

181 scopy, we investigated whether this cellular kinase complex interacts with IE62.

182 converts the transient noncovalent substrate-kinase complex into a covalently cross-linked product by

183 the ortholog of the Aurora B-INCENP protein kinase complex (Ipl1-Sli15) may have a role in this cruc

184 gy in S. cerevisiae, and that the Atg1/Atg13 kinase complex is a key site of signal integration withi

185 a-induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1.

186 The Sid2p-Mob1p kinase complex is an important component of the septatio

187 This kinase complex is assembled by mTOR and its essential co

188 ted)-ATRIP (ATR-interacting protein) protein kinase complex is central to the cellular response to re

189 ted)-ATRIP (ATR-interacting protein) protein kinase complex is crucial for the cellular response to r

190 In its absence, activation of the TAK1-IKK kinase complex is defective, greatly reducing signal tra

191 e, we report that the NF-kappaB inducing IKK kinase complex is localized at the postsynaptic density

192 sites on ATR and ATRIP to understand how the kinase complex is regulated by post-translational modifi

193 The Snf1 protein kinase complex is required for activation of their downs

194 Furthermore, the Snf1 protein kinase complex is required to adapt cellular metabolism

195 The multiprotein mTORC1 protein kinase complex is the central component of a pathway tha

196 e phosphorylation by Src/FAK (focal adhesion kinase) complex is essential for F-actin binding of ACF7

197 a possible target of the PAR-4-STRD-1-MOP-25 kinase complex, is also required for cell shedding.

198 be a kinase that acts as part of a receptor kinase complex, is likely to be a pseudokinase and not a

199 binding subunit of the DNA-dependent protein kinase complex, is nevertheless compatible with viabilit

200 Snf1 kinase complexes isolated from pak1Delta mutant strains

201 ngements in the alpha(v)beta(3) integrin-Lyn kinase complex leading to disruption of Lyn kinase-media

202 motes phosphorylation of AMPK by an upstream kinase complex, LKB1/Mo25/STRAD (liver kinase B 1, mouse

203 ta, and gamma) of the positively acting Snf1 kinase complex localize to the nuclear periphery, result

204 The serine and threonine kinase complex, mammalian target of rapamycin complex 1

205 For Pah1 phosphorylated by the Pho85-Pho80 kinase complex, maximum Nem1-Spo7 phosphatase activity r

206 The kinase complex mechanistic target of rapamycin 1 (mTORC1

207 e class III PtdIns3 (phosphatidylinositol 3) kinase complexes, mediates the production of PtdIns3P, a

208 ere we present evidence that the MEN protein kinase complex Mob1p-Dbf2p localizes to mitotic nuclei a

209 ed but functionally distinct multi-component kinase complexes, mTOR complex 1 (mTORC1) and mTORC2.

210 ucine for activation of the serine-threonine kinase complex mTORC1 and for expression of the transcri

211 At present, inhibitors of the kinase complex mTORC1 are undergoing clinical trials.

212 ls had more activity of the serine-threonine kinase complex mTORC1 but less mTORC2 activity, and acti

213 nine kinase Akt and the metabolic checkpoint kinase complex mTORC1 induces both expression of the glu

214 Dual inhibition of the mTOR kinase complexes mTORC1 and mTORC2 decreases tumor xenog

215 The PI3K-dependent signaling kinase complex mTORC2 (mammalian target of rapamycin com

216 gulates activity of the metabolic checkpoint kinase complex mTORC2 and the serine-threonine kinase Ak

217 manner dependent on the metabolic checkpoint kinase complex mTORC2.

218 eshold to which G(1) cyclin-cyclin-dependent kinase complexes must surpass prior to cells progressing

219 The Snf1 kinase complex of Saccharomyces cerevisiae contains one

220 s physically with Sid2p and Mob1p, a protein kinase complex of the septation initiation network, and

221 mAbs capable of disabling heterodimeric kinase complexes of the epidermal growth factor receptor

222 Retention of these receptor-kinase complexes on the cell surface was dependent on th

223 effect of different cyclin-cyclin-dependent kinase complexes on ubiquitination of p27 in a reconstit

224 eptide that disrupts the inhibitor of kappaB kinase complex or the nonsteroidal anti-inflammatory dru

225 egatively regulated by the phosphate-sensing kinase complex Pho80p/Pho85p and by the nitrogen-sensing

226 ERalpha-activated mitogen-activated protein kinase complex, phosphorylation of ERalpha on serine 118

227 lates focal class III phosphatidylinositol 3-kinase complex (PI3KC3) activity, which is required to i

228 ective autophagic degradation of the IkappaB kinase complex prevents constitutive activation of the i

229 determined if disruption of the Hsp90-eEF-2 kinase complex promoted degradation of the kinase.

230 ator of the class III phosphatidylinositol 3-kinase complex, promotes membrane tethering of protein-f

231 of erythropoietin (EPO) receptor (EPOR) JAK2 kinase complexes propagates signals within erythroid pro

232 istance exercise act to regulate the protein kinase complex referred to as mechanistic target of rapa

233 The ATR-ATRIP kinase complex regulates cellular responses to DNA damag

234 The Drosophila PAN GU (PNG) kinase complex regulates the developmental translation o

235 pathways, the key inputs and outputs of this kinase complex remain unknown.

236 t, IkappaB kinase (IKK)gamma, of the central kinase complex required for NF-kappaB activation, IKK, o

237 rain, we found the Cl(-)-sensitive WNK3-SPAK kinase complex, required for cell shrinkage-induced regu

238 are the regulatory subunits of IKK and TAK1 kinase complexes, respectively.

239 wn as IKK-gamma, is a member of the I-kappaB kinase complex responsible for phosphorylating I-kappaB,

240 omponent of class III phosphatidylinositol-3-kinase complexes responsible for autophagosome nucleatio

241 A crystal structure of the PF-06463922-ROS1 kinase complex revealed favorable interactions contribut

242 Crystal structures of inhibitor-kinase complexes showed that the inhibitor stabilizes a

243 rs earlier than the formation of the FAK.Src kinase complex, suggesting that US28 activates Src befor

244 gliomagenesis by stabilizing cyclin D1-cdk4 kinase complexes, suggesting that cyclin D1 and cdk4 may

245 ) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2.

246 Here we report that removal of the kinase complex TFIIK from TFIIH shifts the TSS in a yeas

247 F2p is the catalytic subunit of a regulatory kinase complex that controls flagellar length and flagel

248 INCENP), a subunit of the conserved Aurora B kinase complex that forms part of the proposed chromosom

249 he phosphoinositide 3-kinase class III lipid-kinase complex that induces autophagy, as an interacting

250 the PI(3) kinase class III (PI(3)KC3) lipid-kinase complex that induces autophagy.

251 tial component of the Beclin1-PI(3)KC3 lipid kinase complex that is an important signalling checkpoin

252 se kinase (ASK), a component of the Cdc7/ASK kinase complex that is crucial for cell proliferation, b

253 atory subunits of a cyclin-dependent protein kinase complex that is essential for normal growth and h

254 kinase alpha (IKKalpha), a component of the kinase complex that leads to NF-kappaB activation, plays

255 of rapamycin complex 1 (mTORC1) is a protein kinase complex that localizes to lysosomes to up-regulat

256 Here, we characterize a new K(+) channel-kinase complex that operates in the metazoan Caenorhabdi

257 n target of rapamycin) complex 2 (mTORC2), a kinase complex that phosphorylates Akt at Ser473 upon ac

258 is under the control of the INCENP-aurora B kinase complex that phosphorylates histone H3 during mit

259 arget of rapamycin complex 1 (mTORC1), a key kinase complex that regulates cell size and growth, is o

260 PNG, PLU, and GNU constitute a novel protein kinase complex that specifically regulates S-M cell cycl

261 ng with the formation of Ci-Sufu and Ci-Cos2-kinase complexes that normally inhibit Ci activity and p

262 accharomyces cerevisiae Mec1-Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an e

263 ; and (3) a membrane-protein phosphatase and kinase complex, the STRIPAK complex, bridges the cis-Gol

264 Tat binds to this kinase complex through a direct protein-protein interact

265 PDK1 associates with the core Hippo pathway-kinase complex through the scaffold protein Salvador.

266 or kappaB (IkappaB) proteins and the IkappaB kinase complex through two major pathways: the canonical

267 lates the IKKbeta subunit within the IkappaB kinase complex to activate NF-kappaB-regulated genes.

268 ul3 ubiquitin complex acted on the wnk4-wnk1 kinase complex to regulate Na(+)/Cl(-) cotransporter (NC

269 essential for the translocation of the LIT-1 kinase complex to the nucleus, the site of its TCF subst

270 induction, and recruitment of the Atg1-Atg13 kinase complex to the pre-autophagosomal structure by st

271 ection, Nef assembles the 2c-sensitive multi-kinase complex to trigger down-regulation of cell-surfac

272 pseudokinases that regulate multiple active kinase complexes to synergistically thwart innate immuni

273 a-arrestin, which is activated via the TORC1 kinase complex upon arginine uptake.

274 e cyclin D1/cyclin-dependent kinase 4 (CDK4) kinase complex, used as a surrogate for cyclin D1 degrad

275 ectivities, and X-ray structures of the drug-kinase complexes using a VEGFR2 TK construct inclusive o

276 ivators Gal4 and VP16 target the Snf1 (AMPK) kinase complex via direct interactions with both the cor

277 tituted kinase assay, in which an active PKR kinase complex was captured from a normal cell extract,

278 The phosphorylation site(s) of K-cyclin/Cdk9 kinase complexes was mapped in the transactivation domai

279 imilar analysis of several constructs of the kinase complex, we propose that assembly is characterize

280 The purified kinase complexes were enzymatically active as judged by

281 Snf1 kinase complexes were purified from cells expressing onl

282 upon overexpression of A1PiZ, both PtdIns 3-kinase complexes were required for delivery of the exces

283 the TNF-alpha-induced pronecrotic RIP1-RIP3 kinase complex, whereas the IkappaB Kinase (IKK) subunit

284 s occurred through activation of the IkappaB kinase complex, which also led to activation of NF-kappa

285 lated by the AUTOPHAGY-RELATED1/13 (ATG1/13) kinase complex, which connects metabolic and environment

286 ine stimulation is controlled by the IkappaB kinase complex, which contains IKKalpha and IKKbeta.

287 the ULK1 kinase complex and the Vps34 lipid kinase complex, which generates phosphatidylinositol 3-p

288 control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats k

289 autophagy depends on the autophagy-related 1 kinase complex, which is also essential for TORC1-regula

290 Both proteins are connected to the Atg1 kinase complex, which is involved in autophagy initiatio

291 m through the kinase activity of the IkappaB kinase complex, which leads to translocation of NF-kappa

292 lates the kinase activity of DNA-PK (protein kinase) complexes, which leads to increased phosphorylat

293 nslation, regulated in Drosophila by the PNG kinase complex whose activity we show here to be under p

294 small interfering RNA, blocking the IkappaB kinase complex with BMS-345541, or using the proteasome

295 association of alpha(v)beta(3) integrin-Lyn kinase complex with ionotropic glutamate receptor subuni

296 ps30, are scaffold proteins bound in a lipid kinase complex with multiple cellular functions, includi

297 the TANK-binding kinase 1-inducible IkappaB kinase complex with upstream signaling molecules in mult

298 performing energy minimizations of inhibitor-kinase complexes with the molecular mechanics code GROMA

299 DFG motif as compared to that seen in other kinase complexes with VX-680.

300 two novel regulatory components of the Stt4 kinase complex, Ypp1 and Efr3.