ライフサイエンスコーパス: kindling

1 f temporal-lobe epilepsy (a process known as kindling).

2 r hippocampus on 2 consecutive days (partial kindling).

3 rs to be largely resilient to the effects of kindling.

4 ed by maximal dentate activation (MDA) acute kindling.

5 ng" effect rather than increase the speed of kindling.

6 hanced seizure susceptibility to hippocampus kindling.

7 otivational consequences of amygdala and VTA kindling.

8 tory changes reported to follow ischemia and kindling.

9 ronal responses were also observed after AGS kindling.

10 ay contribute to the development of amygdala kindling.

11 the initial and also more advanced stages of kindling.

12 s of the CA1 region of the hippocampus after kindling.

13 shakes during both amygdala and hippocampal kindling.

14 in mediating the emergence of PTC during AGS kindling.

15 ) or TRH-NPs for 7 days before initiation of kindling.

16 jected into the hippocampus of rats prior to kindling.

17 tween 3 and 4 months old at the beginning of kindling.

18 1 to 2 seizures appeared following amygdala kindling.

19 s of astrogliosis, were present after 4 d of kindling.

20 o the SNr bilaterally 1 s after cessation of kindling.

21 ses to acoustic stimuli before and after AGS kindling.

22 ffect generalized clonus before or after AGS kindling.

23 onses to acoustic stimuli occurred after AGS kindling.

24 nus, which changed to burst firing after AGS kindling.

25 unkindled GEPR-3s, which is increased by AGS kindling.

26 forelimb (F and F) clonus, not seen prior to kindling.

27 ring generalized clonus before and after AGS kindling.

28 18 adults >1 year of age at the beginning of kindling.

29 receptors contributes to the development of kindling, a form of activity-dependent behavioral plasti

30 Hippocampal kindling, a model of mesial temporal lobe epilepsy, is d

31 Kindling, a model of temporal lobe epilepsy, induces a n

32 res (AGS), but following repetitive AGS (AGS kindling), an additional behavior, facial and forelimb (

33 that 2DG potently reduces the progression of kindling and blocks seizure-induced increases in the exp

34 s in perforant path (but not olfactory bulb) kindling and caused a twofold slowing in progression of

35 neuronal network for AGS as a result of AGS kindling and demonstrate a previously unknown involvemen

36 iseizure effect, impaired the progression of kindling and development of mossy fiber sprouting during

37 r pathway that influences the progression of kindling and mossy fiber sprouting and suggest that NMDA

38 tested on both the development of amygdaloid kindling and on fully developed stage 5 amygdala kindled

39 ged increase of seizure susceptibility after kindling, and diminished sociability.

40 In particular, limbic kindling appears to enhance dendritic inhibition, indica

41 Using amygdala kindling as an indicator of sensitization development, w

42 contrast, animals receiving saline prior to kindling as well as phenobarbital-treated non-kindled an

43 ollimated X-ray beam (18 MV) either prior to kindling, at kindling stage 3, or at kindling stage 5, b

44 g to epilepsy was examined using hippocampal kindling; autismlike behavior was studied using the soci

45 ds obtained once at the beginning and end of kindling, but only when compared to sham control values

46 nificantly increased by irradiation prior to kindling, but was unaffected by irradiation at kindling

47 These data suggest that perforant path kindling causes a persistent increase in hyperexcitabili

48 of forebrain neurocircuitry associated with kindling contributes to psychiatric disturbances involvi

49 ala-kindled seizure development and the post-kindling course in 58 cats (29 males and 29 females), in

50 recurrent evoked seizures early in the post-kindling course.

51 Olfactory bulb kindling developed similarly in wild-type, GluK1, and Gl

52 havioral and electrophysiological indices of kindling development and kindling-induced sprouting of h

53 at CLON and IDA can have opposing effects on kindling development in kittens and is the first report

54 f distinct neurotrophin receptors throughout kindling development in the rat via chronic intracerebro

55 epilepsy, but whether neurotrophins regulate kindling development is as yet unclear.

56 The rate of kindling development was significantly attenuated in -/-

57 l activity-determined functional plasticity (kindling development) as well as a structural plasticity

58 t BHK cells failed to display any effects on kindling development, while recipients of BHK-AK2 cells

59 tence of seizure expression at 4 weeks after kindling development.

60 icles containing TRH (TRH-NPs) could inhibit kindling development.

61 g focal irradiation at various points during kindling development.

62 n sleep than waking at both sites; (2) after kindling, each cat showed cyclic patterns, as follows: (

63 promoted epileptiform discharge in vitro and kindling epileptogenesis in vivo with partial gamma-amin

64 inate receptors in provoking seizures and in kindling epileptogenesis.

65 re focus (amygdala) significantly suppressed kindling expression when assessed by the number of stimu

66 re was performed 24 h later without DBS, the kindling failed to elicit any seizure signs in 6 of thes

67 imals receiving phenobarbital prior to daily kindling failed to recover within 2 months of testing.

68 tion pathways of GFP homologues, such as the kindling fluorescent protein and the Kaede protein, whic

69 timate kappa(2) values for the TagRFP-linker-kindling fluorescent protein tetrameric complex required

70 we determined the crystal structure of the "kindling fluorescent protein" asFP595-A143G (KFP) in the

71 otein, red fluorescent protein (TagRFP), and kindling fluorescent protein, and the S1,min --> S0 emis

72 the animals before or during the 5-week post-kindling follow-up during which seizures were evoked onc

73 However, it is not clear that kindling has a human correlate, so models in which an in

74 The pathway that mediates AGS kindling has been shown to involve the amygdala, which i

75 Taken together, our results demonstrate that kindling has subfield-selective effects on the different

76 led seizures were achieved by daily amygdala kindling, high frequency stimulation was delivered to th

77 These results are consistent with the kindling hypothesis but suggest a threshold at which the

78 Its requirement for epileptogenesis in kindling implicates TrkB and downstream signaling pathwa

79 ptor body (trkB-Fc) inhibited development of kindling in comparison with that seen with saline or hum

80 n AGS neuronal networks before and after AGS kindling in GEPR-3s.

81 antly to the emergence of PTC induced by AGS kindling in GEPR-9s, which is supported by recent prelim

82 rved in the MGB neuronal responses after AGS kindling in GEPR-9s.

83 f can produce limbic seizures which resemble kindling in some aspects.

84 d seizures before and 1-month after amygdala kindling in young cats (<1 year old; n=8; six female and

85 repetition of audiogenic seizure (AGS) ('AGS kindling') in the severe substrain of genetically epilep

86 Repeated, periodic induction of AGS (AGS kindling) in GEPR-9s increases seizure duration and indu

87 n of such processes, as well as blinking and kindling, in fluorescent proteins.

88 nstrated that the initial seizures evoked by kindling increase paired-pulse inhibition at 15-25 msec

89 After AGS kindling, increased neuronal firing occurred, and respon

90 tPA) was tested for its effects on the rapid kindling induced by a series of afterdischarges (ADs) tr

91 Partial amygdala kindling induced c-fos messenger RNA (mRNA) expression,

92 In contrast, partial hippocampus kindling induced c-fos mRNA in the hippocampus only.

93 AGS kindling induced significant increases in acoustic respo

94 The impairment of kindling-induced axonal sprouting in the null mutants co

95 We examined AGS kindling-induced changes in vlPAG extracellular action p

96 itical role of PRh in generation of this AGS kindling-induced convulsive behavior.

97 Kindling-induced granule cell axon sprouting as measured

98 intensities are unaffected by either NMDA or kindling-induced modulation of late paired-pulse depress

99 nd Narp-/- mice had increased sensitivity to kindling-induced seizures.

100 ological indices of kindling development and kindling-induced sprouting of hippocampal granule cell a

101 With the hope of kindling interest in this incredibly versatile range of

102 from tonic to burst firing suggest that AGS kindling involves increased cPRF excitability.

103 Kindling is a model of the neural plasticity that occurs

104 e structures from which to induce electrical kindling, is comprised of distinct nuclei that possess d

105 antagonist MK801 impedes the progression of kindling, it was of interest to determine whether MK801

106 ilarities to the viewing population, thereby kindling kin-motivated responses (for example, prosocial

107 icating and withdrawal episodes leading to a kindling-like increase in seizure susceptibility.

108 of the mechanism underlying the CIE induced kindling-like phenomenon observed in humans.

109 icating ethanol and withdrawal, leading to a kindling-like state of behavioral excitability.

110 BS, if well timed with the onset of amygdala kindling, may exert long lasting effects on the networks

111 In the kindling model in rats, BUM5 was more efficacious than b

112 The exquisite sensitivity of agonists in the kindling model of epilepsy and the lack of evidence for

113 echanistic aspects of this phenomenon in the kindling model of epilepsy by applying focal irradiation

114 In this experiment, we used the electrical kindling model of epilepsy to determine whether seizures

115 on is increased after seizures evoked in the kindling model of epilepsy, but whether neurotrophins re

116 have been modelled in animals mostly by the kindling model of epilepsy, in which repetition of subco

117 locked the antiseizure activity of AP in the kindling model of epilepsy.

118 Subsequently, we utilized the kindling model of temporal lobe epilepsy to determine if

119 Utilizing the rat kindling model of temporal lobe epilepsy, a single TRH m

120 In the kindling model of temporal lobe epilepsy, several physio

121 inhibitor 2-deoxy-D-glucose (2DG) in the rat kindling model of temporal lobe epilepsy.

122 e powerfully inhibits epileptogenesis in the kindling model.

123 ional BDNF(-/-) and TrkB(-/-) mice using the kindling model.

124 ogressive development of seizures in the rat kindling-model.

125 n suppressing seizure progression in the rat kindling-model.

126 Cgamma1 in hippocampi in the pilocarpine and kindling models in wild-type mice.

127 leptogenesis in the hippocampus and amygdala kindling models.

128 hic recordings before (n=2) and 1 month post-kindling (n=2); 5-min recording epochs were temporally a

129 We found: (1) before and after kindling, NE and 5-HT but not DA concentrations were sig

130 nobarbital was coupled with daily electrical kindling of the amygdala beginning 48 h after a unilater

131 lutamate analogue, kainate, or by electrical kindling of the amygdala.

132 study examined the effects of perforant path kindling on 0-Mg(2+)-induced epileptiform bursting in th

133 s in the literature about chronic effects of kindling on monoamines and sleep-waking state patterns.

134 Here we examined the effect of kindling on stimulus-induced c-Jun N-terminal kinase (JN

135 it accelerated kindling rates and rapid post-kindling onset of multifocal spontaneous epilepsy with a

136 stribution of the mossy fibers after partial kindling or kainate-induced seizures.

137 tic risk exhibit an increase in the speed of kindling, or are they "prekindled"?

138 in (5-HT) before and during a 1-day amygdala kindling paradigm.

139 The alternating, post-kindling pattern suggested "rebound" effects which could

140 The kindling phenomenon is enhanced by the Ala143 --> Gly po

141 ble role of chromophore isomerization in the kindling phenomenon, we determined the crystal structure

142 factors for major depression impact on this "kindling" phenomenon?

143 sponse has been hypothesized to represent a 'kindling' phenomenon.

144 Furthermore, when the same amygdala kindling procedure was performed 24 h later without DBS,

145 These data indicate that specific kindling processes are initiated during the interval of

146 Our results indicate that kindling produces selective effects on the number and mo

147 in a significant reduction in seizure ADD as kindling progressed, while the number of stimulations re

148 naptic activity, signaling that may modulate kindling progression and/or neuronal death.

149 The post-kindling progression can be stopped or minimized by susp

150 Repeated brief seizures evoked by kindling progressively increase seizure susceptibility a

151 not efficacious in the basolateral amygdala kindling rat model of temporal lobe epilepsy, and it led

152 (2) CLON retarded and IDA accelerated kindling rate, defined as the number of afterdischarges

153 reased hippocampal excitability, accelerated kindling rate, prolonged increase of seizure susceptibil

154 scharge in the central amygdala and enhanced kindling rate.

155 he youngest animals also exhibit accelerated kindling rates and rapid post-kindling onset of multifoc

156 Post-kindling records in each cat were divided into two group

157 avioral seizure activity and compared to pre-kindling records.

158 Electrical kindling refers to the seizure-generating properties of

159 dic repetition of AGS in GEPR-9s induces AGS kindling resulting in expansion of the seizure network t

160 ntary synaptic currents (quantal size) after kindling results directly from a 75% increase in the num

161 The present study investigated whether AGS kindling results in changes in vlPAG neuronal firing by

162 zed clonus, but daily repetition of AGS (AGS kindling) results in an additional seizure behavior, fac

163 ndling, but was unaffected by irradiation at kindling stage 3, and significantly reduced by irradiati

164 ay beam (18 MV) either prior to kindling, at kindling stage 3, or at kindling stage 5, by exposure of

165 rior to kindling, at kindling stage 3, or at kindling stage 5, by exposure of the left amygdala to a

166 and significantly reduced by irradiation at kindling stage 5.

167 In the adult brain, repeated kindling stimulation of limbic pathways increases the NM

168 received daily treatments before receiving a kindling stimulus 3 h later.

169 Additionally, when seizures were induced by kindling, the number of stimulations required to evoke a

170 MDA channels correspond to those observed in kindling; the openings are considerably long, requiring

171 nes, SwLo rats had a lower final hippocampal kindling threshold and more wet dog shakes during both a

172 t undergoes a remarkable transition, termed "kindling", to a long-lived fluorescent state (lambda(em)

173 Kindling trials and afterdischarge (AD) were controlled

174 s appears to be independent of the number of kindling trials provided and cumulative AD.

175 Epileptogenesis assessed by development of kindling was inhibited in trkB(PLC/PLC) compared with co

176 The development of amygdaloid kindling was significantly retarded in 2R,4R-APDC (10 nm

177 eve full amygdala and hippocampal electrical kindling were similar in the two rat lines, SwLo rats ha

178 development of seizures in rats by amygdala kindling, which models temporal lobe epilepsy, allows th

179 diogenic seizures (AGS) leads to audiogenic 'kindling' with increased seizure duration and additional

180 present study asked whether partial amygdala kindling would affect the expression of conditioned fear