ライフサイエンスコーパス: kinetic

1 ype activity and single-turnover pulse-chase kinetics.

2 s it only had a minor effect on deactivation kinetics.

3 chromatin state modulate cleavage and repair kinetics.

4 of protein drugs requiring sustained release kinetics.

5 mined myocardial salvage and creatine kinase kinetics.

6 ute to all intestinal lineages with distinct kinetics.

7 as dietary protein digestion and absorption kinetics.

8 gnetic field can be used to accelerate assay kinetics.

9 of detection and minimally altered electrode kinetics.

10 ity, and more physiological action potential kinetics.

11 gregates, albeit with individually different kinetics.

12 QDs affect the dot-to-dot electron-transfer kinetics.

13 edium due to the profoundly different atomic kinetics.

14 d carbon, along with comparable capacity and kinetics.

15 5-HT is an important pro-kinetic agent in the colon.

16 charged particles that comprise an undamped kinetic Alfven wave.

17 ep mechanism was elucidated through detailed kinetic analyses and suggests an enzyme isomerization mo

18 In this paper, we report molecular kinetic analyses of water spreading on hydrophobic surfa

19 ce temperature and Z-value commonly used for kinetic analysis in food microbiology.

20 Intriguingly, cell kinetic analysis of clonal isolates derived from single

21 We describe a novel method of kinetic analysis of radioligand binding to neuroreceptor

22 Enzyme kinetic analysis revealed that BA inhibited tyrosinase a

23 to evaluate (18)F-AV-1451 binding with full kinetic analysis using a metabolite-corrected arterial i

24 ction and to compare parameters derived from kinetic analysis with SUV ratio (SUVR) calculated over d

25 cular interactions, making them suitable for kinetic analysis.

26 uctures of the SDA complex coupled to enzyme kinetic and cell-based studies to provide structure-func

27 Kinetic and equilibrium experiments show that poly(dA:dT

28 data treatment that enables determination of kinetic and equilibrium partition constants.

29 Moreover, the renal excretion kinetic and intrahepatic albumin binding affinity of CyG

30 ard quantum chemistry techniques to describe kinetic and mechanistic aspects of ion-pair formation, a

31 Based on mutational, kinetic and modeling analyses, a catalytic mechanism inv

32 Kinetic and mutational analysis confirmed several featur

33 The comprehensive kinetic and partition models were applied to the membran

34 nty were estimated for the first time in the kinetic and spectrometric techniques using the certified

35 By means of kinetic and spectroscopic studies, we have identified th

36 Kinetic and thermodynamic analyses evidence a concerted

37 n and the surrounding environment that alter kinetic and thermodynamic equilibria.

38 flection fluorescence microscopy (TIRFM) and kinetic and thermodynamic measurements, we established a

39 Used in combination, these kinetic and thermodynamic parameters can help toward the

40 While both kinetic and thermodynamic protein stability are analysed

41 Detailed electrochemical, kinetic and vibrational spectroscopic studies, in tandem

42 s response attributes, including termination kinetics and adaption properties, OSNs in either NCKX4(-

43 Proper tuning of kinetics and emission wavelengths enables the generation

44 f both conformers and have characterized the kinetics and energetics of the conformational switch.

45 The extraction kinetics and equilibrium concentrations of caffeine and

46 Both fast uptake kinetics and great sorption selectivity toward PFOS are

47 We evaluated the viral kinetics and immune responses induced after an i.v. infe

48 aken orally, in particular, the drug release kinetics and interaction with the gastrointestinal (GI)

49 In addition, adsorption kinetics and isotherms were collected, and the Weber-Mor

50 Kinetics and molecular dynamics simulations on several G

51 ity at catalyst interface, resulting in poor kinetics and negative catalytic performance.

52 1,327 mAh/(g of S), along with fast reaction kinetics and negligible polysulfide dissolution.

53 free-energy calculations, we determined the kinetics and pathways for major products (ethylene and m

54 hese W237 substitutions show in vitro growth kinetics and plaque morphologies similar to those of the

55 To close this gap, we now report transient kinetics and product analysis of the dechlorinating flav

56 ne the detailed reaction mechanism including kinetics and product selectivity as a function of pH and

57 ested aggregates and effects of mutations on kinetics and products of aggregation.

58 Because the kinetics and products of the reaction of these oxidants

59 In this study, we compared the in vivo kinetics and proteomes of banded, mature, and hypersegme

60 adation of anthocyanins followed first-order kinetics and reaction rate constants (k values), which w

61 umour and distant organs with different time kinetics and regulate spatiotemporal tumour plasticity.

62 Here, we characterise the kinetics and structure of murine CD4 T cell memory subse

63 nism of Prp activity, we analyzed Prp enzyme kinetics and substrate preference using a fluorogenic pe

64 MSO were assessed offering insights into the kinetics and thermodynamics of the switching process.

65 de of the mouse that slows down the response kinetics and, by doing so, it reduces the peripheral tem

66 en partially revealed through spectroscopic, kinetic, and dynamic investigations.

67 core that ensures fast macrocycle threading kinetics, and (c) sialic acid blocking groups that preve

68 -) anions, drastically improves the reaction kinetics, and enables the electrolysis at low temperatur

69 ved reaction safety and accelerated reaction kinetics, and have synthesised several active pharmaceut

70 More generally, our results indicate that kinetics, and not just thermodynamics, can significantly

71 oes not linearly equate with transcriptional kinetics, and our data suggest that SMAD2 recruits multi

72 jective was to evaluate the biodistribution, kinetics, and radiation dosimetry of (64)CuCl2 in humans

73 tions are built upon both thermodynamics and kinetics, and then successfully used to tailor material'

74 In the first part of the work, a kinetic approach was taken to investigate the effect of

75 Thus, transient species possessing fast kinetics are enhanced relative to other components and c

76 ion transport, where the reaction fronts and kinetics are maintained within the neighbouring nanorod.

77 s by 2 days post-exposure; virus replication kinetics are similar to those observed in animals infect

78 s and the mechanism determining the reaction kinetics are still unknown.

79 tions of their stability (thermodynamics and kinetics) are discussed, challenges for the application

80 Using order-disorder kinetics as a generic example, we construct and analyze

81 TL to intrinsic termination, we developed a kinetic assay that distinguishes effects of TL alteratio

82 Kinetic assays showed rapid bactericidal effect of LyeTx

83 Using site-directed mutagenesis, kinetic assays, and quantitative mass spectrometry, we p

84 The kinetic association rate constant of the binding of the

85 activation enthalpy terms to account for the kinetics at all other temperatures.

86 In this paper, we present a reaction kinetics-based technique that solves this problem, signi

87 nerve and also balanced differences in decay kinetics between responses to different stimulation stre

88 T, (99m)Tc-PSMA-I&S showed delayed clearance kinetics but identical uptake in PSMA-positive tissues i

89 cally combine to accelerate surface reaction kinetics by several orders of magnitude.

90 mental results showed that the one-calibrant kinetic calibration technique can be used for determinat

91 live cells, one that truly suppresses on-off kinetics, characteristic of vinblastine, and the other a

92 ase-7 bound to a fragment hit and a thorough kinetic characterization of a zymogenic form of the enzy

93 trodes allow for the in situ mechanistic and kinetic characterization of electrochemical reactions wi

94 erimental framework called the cross-linking kinetics (CLK) assay, which uses time-dependent formalde

95 re, we use steady-state and pre-steady-state kinetics combined with mutagenesis and structural studie

96 By disentangling the quantum kinetic complexities, we prove that fcc lithium is the g

97 Reactions followed reversible biphasic kinetics, consistent with the presence of two electrophi

98 nes were selectively accessed under uncommon kinetic control.

99 and analogous poly-alkenes under exceptional kinetic control.

100 To determine the kinetic course of nitrosation reactions, a systematic st

101 to this idea, we have found that there is a kinetic "damper" present in the olfactory transduction c

102 ucture of a monocot CAD combined with enzyme kinetic data and a catalytic model supported by site-dir

103 Kinetic data suggest thioether-Pd-catalyzed reactions ca

104 The aggregation kinetics data were in good agreement with the classic De

105 imulated gastrointestinal conditions using a kinetic digestion procedure.

106 roperties of MYO1C isoforms, adding to their kinetic diversity.

107 Below approximately 60 K the rebinding kinetics do not follow these predictions unless quantum

108 Defining the kinetics, dynamics, and cellular location of uncoating o

109 gly charged lipid ions with electrons having kinetic energies of 5-16 eV.

110 efforts have been focused on extracting the kinetic energy from the motions of water drops on hydrop

111 ided a detailed time-resolved mechanism, and kinetic equations solution for the ensemble long-time pr

112 This provides quantitative and kinetic evidence that SA acts at or near the ubiquinone

113 A series of kinetic experiments was conducted to gain detailed insig

114 As shown through stopped-flow kinetic experiments, electron transfer capable cytb 5 -

115 The kinetics experiments also shed light on the effects of c

116 From the results of the kinetics experiments, we determined that the reversion o

117 he aragonite are enriched above the expected kinetic fractionation of meteoric waters, suggesting a v

118 report here the preparation and H2S release kinetics from a series of isomeric caged-carbonyl sulfid

119 BPAM344 markedly decreased desensitization kinetics (from 5.5 to 775 ms), whereas it only had a min

120 The use of chemical kinetics has recently enabled highly accurate quantifica

121 Analysis of secretion kinetics identified a first phase (0-2 min) mediated by

122 We measured Abeta concentrations and kinetics in 77 adults aged 60 to 87 years with and witho

123 nfirmation to the theory describing reaction kinetics in a segregated flow system.

124 investigated by measuring their aggregation kinetics in different aqueous solution chemistries.

125 he effect of this coupling on the lithiation kinetics in epitaxial Fe3 O4 thin film on a Nb-doped SrT

126 For both proteins, the kinetics in nanodiscs shows the characteristics observed

127 The delayed development of the sigmoidal kinetics in phenol-water uptake demonstrates that long-r

128 zation underlies disturbed insulin secretion kinetics in T2D.

129 Fast elution kinetics in the column setup were observed during the re

130 systems biology model of VEGF transport and kinetics in tumor-bearing mice to include a tumor compar

131 endent below approximately 10 K, and a large kinetic isotope effect (KIE) is observed upon substituti

132 We used kinetic isotope effect (KIE), commitment factor (Cf), an

133 alyzed proton transfer shows a prominent H/D kinetic isotope effect, which is determined to be 8.3 x

134 incorporation into biomolecules and minimal kinetic isotope effect.

135 Kinetic isotope effects indicated that the C-H bond clea

136 ion as mechanically and Ca(2+)-induced force kinetics (k+Pi(1) approximately k-Pi approximately kTR a

137 ss the energy barrier that dominates folding kinetics, known as the transition path time.

138 first-order phase transformations with slow kinetics largely restricted by the nucleation and growth

139 to 20mM) was analyzed and the mechanisms and kinetic laws of tryptophan N-nitrosation were determined

140 simulations suggest that LSD's slow binding kinetics may be due to a "lid" formed by extracellular l

141 This is the first elucidation of the kinetic mechanism of a two-component flavin-dependent mo

142 Procedures to define kinetic mechanisms from catalytic activity measurements

143 Kinetic, mechanistic, and in situ spectroscopic studies

144 millisecond resolution, we derive a detailed kinetic model for Hel308 translocation along ssDNA that

145 thermodynamic measurements, we established a kinetic model of Ena/VASP-mediated actin filament elonga

146 A comprehensive kinetic model was established to elucidate the mechanism

147 plication opportunities and accessibility of kinetic modeling across the field.

148 rsional activation energies affords accurate kinetic modeling of both isothermal and nonisothermal de

149 The DFT simulation and kinetic modeling of the nitroso oxide transformations as

150 r clearance changes on SUVRs and noninvasive kinetic modeling outputs.

151 RACIPE generates an ensemble of random kinetic models corresponding to a fixed circuit topology

152 us to make a quantitative validation of the kinetic modification expected to occur in supersaturated

153 lecular conformation analysis, and real-time kinetic monitoring of complex biological interactions.

154 been studied experimentally and by means of kinetic Monte Carlo modeling.

155 This has implications for the assembly kinetics, morphology, and toxicity of all Abeta isoforms

156 Superior kinetics of (100) facets at the vertices of truncated oc

157 we tested in vivo organ and tumor uptake and kinetics of (18)F-FETrp in patient-derived xenograft mou

158 PSMA affinities (IC50) and internalization kinetics of (99m)Tc-MAS3-y-nal-k(Sub-KuE) and (99m)Tc-ma

159 se microscopy to characterize the maturation kinetics of 50 FPs that span the visible spectrum at two

160 rt bioreactor performance and dehalogenation kinetics of a D. mccartyi-containing consortium in an up

161 l subunit of the BAM complex, on the folding kinetics of a model OMP (tOmpA) using fluorescence spect

162 The cleavage kinetics of a number of disulfides were investigated usi

163 FcRn involvement, intracellular pathway, and kinetics of albumin trafficking by flow cytometry, quant

164 In-depth investigations of the kinetics of aqueous chemistry occurring in microdroplet

165 redictions by reconstituting the binding and kinetics of Arf and Brag2 in artificial membranes.

166 is predominantly dominated by the attachment kinetics of atomic clusters in the liquid phase, melting

167 novel platinated-DNA substrate to establish kinetics of ATR-pS435 and XPA's associations with cispla

168 to other antiseizure agents but with slower kinetics of binding and unbinding.

169 (NPQ) states, we find that the fluorescence kinetics of both PSI are nearly identical.

170 For the first time, the growth kinetics of CaCO3 under more realistic well conditions h

171 ures by TiO2 NPs suggests the mechanisms and kinetics of cell death may be influenced by nano-scale m

172 wide temperature range and compared with the kinetics of CO binding in other heme systems such as myo

173 The ultrafast kinetics of CO rebinding to carbon monoxide oxidation ac

174 e transition state, to describe inactivation kinetics of enzymes and micro-organisms subjected to hea

175 etic levitation (MagLev) to characterize the kinetics of free-radical polymerization of water-insolub

176 We determined the kinetics of growth and turnover of nitric oxide (NO) and

177 Thermodynamics and kinetics of H2O splitting are largely controlled by the

178 of TF-FVIIa can transiently escape the slow kinetics of Kunitz-type inhibition by TF pathway inhibit

179 The kinetics of lipolysis, micelle formation and carotenoid

180 The kinetics of macroscopic currents mediated by alpha1(D43C

181 ocyte complexes display distinctly different kinetics of MAPK activation in the cumulus cells, much i

182 conducted in Belgium during 2008-2014 on the kinetics of maternal pertussis antibodies in unvaccinate

183 cting their timescale and amplitude from the kinetics of microtubule growth and cap maturation.

184 remained viable after 6 months although the kinetics of mineralization and cell-mineral interactions

185 dsFP-based miR-132 sensor revealed the rapid kinetics of miR-132 activation in cortical neurons under

186 measuring the single-turnover incorporation kinetics of non-fluorescent native nucleotides by DNA po

187 Results showed that energetics and kinetics of NTD self-assembly are highly conserved acros

188 ogy, we lack a detailed understanding of the kinetics of nucleic acid hybridization.

189 We characterized kinetics of oral shedding during primary and chronic inf

190 emiquantitative theoretical treatment of the kinetics of outer sphere electrochemical reactions.

191 The growth kinetics of perovskite crystals is scrutinized by in sit

192 ge-sensor return slowing correlated with the kinetics of pore opening.

193 ure of astrocytes to variant CJD (vCJD), the kinetics of prion replication occur in a prion protein c

194 The kinetics of proteolysis and lipolysis differed according

195 ers in the vessel basement membrane, and the kinetics of regression were dose dependent.

196 To characterize the kinetics of RNAi trigger delivery and 5-phosphorylation

197 amendments can affect rice uptake of As, the kinetics of Si dissolution and nutrient availability can

198 Determining the real-time kinetics of single players such as RPA in the presence o

199 In this study, the kinetics of SO2 reactions on MnO2 with different morphol

200 show that OnGuard2 faithfully reproduces the kinetics of stomatal conductance in Arabidopsis thaliana

201 nature of sugar-channel interactions and the kinetics of sugar association and dissociation.

202 We have demonstrated that the kinetics of the B cell response are similar for all four

203 an adoptive transfer model to elucidate the kinetics of the effector CD8(+) T cell response in the l

204 se fertilizers (CRFs) can change the release kinetics of the fertilizer nutrients through an abatemen

205 hematical modeling, which included the decay kinetics of the fluorescence of the miRNA sensors, demon

206 was previously interpreted as a signature of kinetics of the force-generating step in the cross-bridg

207 lateau potential depends on the location and kinetics of the GABAergic inputs and is achieved by the

208 l persistence, but little is known about the kinetics of the generation, the tissue distribution or t

209 lation of melanopsin determines the recovery kinetics of the intrinsic melanopsin-based photoresponse

210 tle is known, however, about the termination kinetics of the intrinsic melanopsin-based phototransduc

211 We demonstrate rapid dissolution kinetics of the microneedles in skin.

212 s that elucidate the components, timing, and kinetics of the multivalent role of ubiquitin signals in

213 al of this paper was to evaluate the in vivo kinetics of the novel tau-specific PET radioligand (18)F

214 The kinetics of the oxidation and reduction process are exam

215 The nanosecond electronic spectra and kinetics of the radical pairs from various crystalline t

216 dicated a surface-controlled electrochemical kinetics of the resorufin reduction on the modified ITO

217 tions for both the affinity and dissociation kinetics of this family of ligands.

218 ndicate a role for H2A.Z in coordinating the kinetics of transcription elongation and splicing.

219 nclear how changes in chromatin states alter kinetics of transcription.

220 0 to 1, phosphate accelerated the reduction kinetics of V10 and V4 and enhanced the stability of the

221 blinking of an organic dye, the dissociation kinetics of very short DNA and conformational changes of

222 f control and Il1r1(-/-) mice evaluating the kinetics of viral replication and cytokine production re

223 perativity is accomplished by increasing the kinetic on-rate without altering the off-rate and has a

224 rons of the reduced sensitizer with biphasic kinetics on a much longer time scale of ten to several h

225 ion has not yet been quantified, in terms of kinetics or thermodynamics, nor has the underlying molec

226 m(2).mL(-1), hence enhancing the extraction kinetics over conventional extraction methods.

227 e conversion processivity, which is the only kinetic parameter of the model.

228 We derived average values of (18)F-FMISO kinetic parameters for NSCLC lesions as well as for norm

229 t formaldehyde-cross-linking data to extract kinetic parameters of chromatin binding.

230 Our approach does not rely on kinetic parameters, and therefore points to a theoretica

231 omposition and NW composition using relevant kinetic parameters.

232 herency affect the nucleus growth, shape and kinetic pathways.

233 he visual field have been refined from early kinetic perimetry to current standard automated perimetr

234 amework for describing a broad range of such kinetic processes without detailed knowledge of the unde

235 on corresponds to beta-adduct formation (the kinetic product), while the slow reaction corresponds to

236 ceptor (hA3R) antagonists to determine their kinetic profiles and affinities.

237 iochemically distinct, with different enzyme kinetic profiles and primary amino acid sequences.

238 effect of these dynamic perturbations on the kinetic profiles of both proteins.

239 However, we observe distinct kinetic profiles, even for proximal sites, and this sugg

240 Our approach, termed polymerase kinetic profiling (PKPro), involves monitoring XNA synth

241 and reduces a mycothiol arsenate adduct with kinetic properties different from those of Mrx1.

242 This suggests that kinetic properties of translation can determine the spat

243 KCTD12/KCTD16 hetero-oligomers impart unique kinetic properties on G-protein-activated Kir3 currents.

244 lassical monocytes with unique molecular and kinetic properties.

245 tinct substrate-bound protein with different kinetic properties.

246 e photoacids and its influence on the unique kinetic rates and diffusion properties of the photoacid'

247 tructural differences between kinesins alter kinetic rates in the ATPase cycle to produce functional

248 Kinetic rates increased with an increase in pH from 5 to

249 y compensates for a cold-induced decrease in kinetic rates-properties of rhodopsin that mediate rod s

250 tibodies is fundamentally limited by binding kinetic rates.

251 Lactate kinetics rather than initially elevated lactate concentr

252 Through synthetic control of the kinetic reaction pathway, a layered NMC71515 with low ca

253 ge to experimentally disentangle the complex kinetic reaction pathways that underlie successful coass

254 Current densities recorded in the kinetic region of cathode operation, at fuel cell voltag

255 ities, although the charging and discharging kinetics remain unchanged.

256 ates in human and mosquito cells with growth kinetics representative of wild-type ZIKV.

257 process considerations of their use in both kinetic resolution and asymmetric synthesis.

258 epresents the first small-molecule catalyzed kinetic resolution of aliphatic amines.

259 ted as the racemization pathway in a dynamic kinetic resolution of allylic azides.

260 A new catalyst for the dynamic kinetic resolution of azole hemiaminals has been develop

261 A Bronsted acid catalyzed kinetic resolution of primary amines is described that i

262 This dynamic kinetic resolution process offers a general approach to

263 probe led to inversion of configuration in a kinetic resolution with an extremely high selectivity fa

264 trate that by integrating the electrical and kinetic responses the flexible ZnO sensor can be used fo

265 Kinetic restriction of a thermodynamically favourable eq

266 cleotide receptor expression and hCPC growth kinetics revealed downregulation of select P2 receptors,

267 ived the correct, previously known molecular kinetic scheme describing the activation and inactivatio

268 ation assay that enables the relatively fast kinetic screening of multiple compounds.

269 be invoked to design polymer electrodes with kinetic selectivity toward redox active species and help

270 Channel dissociation kinetics show even stronger dependence, with the dwell t

271 se from olive (Olea europaea), had enzymatic kinetics similar to the olive native enzyme.

272 . typhi(GFPuv) succumb to the infection with kinetics similar to those for animals infected with wild

273 al RT network featuring slow Cl(-) extrusion kinetics, similar to those we found experimentally, mode

274 We identify two distinct modes of kinetic stabilization in live cells, one that truly supp

275 tic of vinblastine, and the other a "pseudo" kinetic stabilization, characteristic of paclitaxel, tha

276 are likely required for visualizing distinct kinetic steps of transcription on a single-copy gene in

277 Kinetic studies facilitated by photochemical radical gen

278 Previous kinetic studies provided evidence for the formation of a

279 Density functional theory calculations and kinetic studies suggest the reaction is catalyzed by tra

280 , rapid injection NMR spectroscopy (RI-NMR), kinetic studies, and computational analysis has enabled

281 atus including bone mineral density, calcium kinetics studies, and markers of bone remodeling.

282 ed the peroxide shunt pathway by using rapid kinetic techniques to monitor the enzyme activity with i

283 cO4(-) and CrO4(2-) and much slower reaction kinetics than those measured in studies with biologicall

284 lucidated by creating channelrhodopsins with kinetics that are accelerated or slowed over orders of m

285 taining flavin and tryptophan radicals shows kinetics that differ markedly from those of closely rela

286 The other phases of Pi-induced force kinetics that occur in the absence of "give" yield the s

287 1:1, we were able to directly compare uptake kinetics, the mode of uptake, trafficking and safety of

288 Veatch and Stryer, derived in 1977, and the kinetic theory-based model for intraoligomeric FRET, der

289 which differ significantly from traditional kinetic-theory-based, macroscale statistical mechanics m

290 Here, a combination of kinetic, thermodynamic, and in situ spectroscopic measur

291 Excitingly, our kinetic, thermodynamic, and structural analysis revealed

292 esters impacted cocoa butter crystallization kinetics, though this depended on surfactant structure a

293 blished data from transient and steady-state kinetics to model a minimal eight-state ATPase cycle.

294 experimental studies linking oxide reduction kinetics to thermodynamics remain scarce.

295 There was a significant increase in the kinetic uptake coefficient of SO2 (gammaSO4(2-),light) f

296 y measured single-integrin-molecule adhesion kinetics using an optical trap, and diffusion using fluo

297 in the eag domain-CNBHD interaction with the kinetics, voltage-dependence, and ATP-dependence of VDP.

298 utationally tractable approach to RNA-ligand kinetics, we overcome the two main difficulties by apply

299 Viability and cell cycle kinetics were measured by using flow cytometry.

300 roscopy), and ascorbic acid (AA) degradation kinetics were performed.