1 dritic block, which significantly simplifies
kinetic analyses.
2 on opposite O(6)-methylG, using steady-state
kinetic analyses.
3 ncentrations was performed using two related
kinetic analyses.
4 ating were estimated by using single channel
kinetic analyses.
5 nteractions by equilibrium binding and rapid
kinetic analyses.
6 A, IsdB, IsdC, and IsdE by spectroscopic and
kinetic analyses.
7 NA ligase IV/XRCC4 via quantitative in vitro
kinetic analyses.
8 been paralleled by the development of modern
kinetic analyses.
9 his specific reactivity by thermodynamic and
kinetic analyses.
10 tion of surface plasmon resonance and enzyme
kinetic analyses.
11 ate methods in conjunction with steady-state
kinetic analyses.
12 determined by NMR titration and pH-dependent
kinetic analyses.
13 itro kinetic properties in multiple turnover
kinetic analyses.
14 l structures and performing pre-steady-state
kinetic analyses.
15 by mass spectrometry and electrophoretic and
kinetic analyses.
16 much less stable complex, as demonstrated by
kinetic analyses.
17 can be interpreted using conventional enzyme
kinetic analyses.
18 ies of PTEN, enabling structure-function and
kinetic analyses.
19 Semiquantitative
kinetic analyses allow the resolution of the effects of
20 Computationally guided mutagenesis and
kinetic analyses allowed the identification of the enzym
21 The
kinetic analyses also indicated that binding of acetyl p
22 Landscape and
kinetics analyses also indicate that the parallel beta-s
23 Using
kinetic analyses and a reconstituted in vitro transcript
24 Steady-state
kinetic analyses and binding assays were consistent with
25 Kinetic analyses and fluorescent probe binding studies s
26 Here we show by
kinetic analyses and inductively coupled plasma emission
27 ransiently transfected HEK293 cells and used
kinetic analyses and modeling to describe the full range
28 ed GluN1/GluN2A single-channel currents with
kinetic analyses and modeling to probe these class-speci
29 Kinetic analyses and molecular modeling showed that the
30 ing from these computations were verified by
kinetic analyses and mutational studies.
31 Detailed
kinetic analyses and parameter estimation for a five-sta
32 Kinetic analyses and pH dependence studies of the wild t
33 ep mechanism was elucidated through detailed
kinetic analyses and suggests an enzyme isomerization mo
34 of these mutants were evaluated using enzyme
kinetic analyses and then assayed in three cancer cell l
35 Mutagenesis, single-channel
kinetic analyses and thermodynamic mutant cycle analyses
36 Using steady-state
kinetics analyses and molecular docking, we not only con
37 spectroscopy, electrochemistry, stopped-flow
kinetic analyses,
and EPR measurements were supported by
38 Site-directed mutagenesis,
kinetic analyses,
and peptide inhibition assays have fur
39 Both thermodynamic and
kinetic analyses are possible.
40 Our results from mutagenesis and enzyme
kinetics analyses argue that a general base mechanism is
41 Steady state
kinetic analyses as a function of biotin, ATP, or a mini
42 inferred from multiple pieces of data using
kinetic analyses based on appropriate mathematical model
43 For
kinetic analyses,
blood activity was measured in 18 samp
44 o be obvious from the initial structural and
kinetic analyses but become less clear on deeper investi
45 Kinetic analyses by (1)H NMR spectroscopy showed less th
46 Kinetic analyses combined with microscale thermophoresis
47 Here, we present thorough
kinetic analyses combined with structural characterizati
48 Mutagenesis and
kinetic analyses confirm that the H-loop is particularly
49 nce ZPI forms a stable complex with FXa, and
kinetic analyses confirmed that PZ acted catalytically t
50 Kinetic analyses confirmed this hypothesis through an un
51 Our detailed
kinetic analyses demonstrate a robust capacity for Cys-S
52 These detailed equilibrium and
kinetic analyses demonstrate that E295 is not irreplacea
53 phase, at the expense of mitotic cells, and
kinetic analyses demonstrate that Id2a is required for S
54 Steady-state
kinetic analyses demonstrate that one of these fragments
55 Kinetic analyses demonstrate that rephosphorylation of S
56 Our
kinetic analyses demonstrated that BCP can utilize a var
57 Detailed
kinetic analyses demonstrated that the in vitro phosphor
58 ty chromatography and intrinsic fluorescence
kinetic analyses demonstrated that the reduced heparin a
59 This, together with pre-steady state
kinetic analyses,
electron paramagnetic resonance spectr
60 The spectroscopic and
kinetic analyses enable a mechanism to be proposed for b
61 Kinetic analyses following inhibition of TORC2, supporte
62 Steady-state
kinetic analyses for nucleotide incorporation by pol eta
63 Steady-state
kinetic analyses for nucleotide incorporation by yeast p
64 Kinetic analyses for PglB revealed clear K(M)-only modul
65 A active site, which based on structural and
kinetic analyses has been tailored to bind the small, fo
66 Thermodynamic and
kinetic analyses have been applied to discover condition
67 s has yet to be determined as structural and
kinetic analyses have provided contradictory results.
68 directed mutagenesis, mass spectrometry, and
kinetic analyses identified S(230) in hBVR (225)RNRYLSF
69 wavelength and photodiode array stopped-flow
kinetic analyses identify a transient Compound I species
70 The results of
kinetic analyses imply that the aptamers bind AlkB away
71 es covalent labeling, mass spectrometry, and
kinetic analyses in a straightforward workflow applicabl
72 Kinetic analyses in GATA-1-null cells indicated that ER-
73 on, small angle x-ray scattering, and enzyme
kinetic analyses in solution that the active form of DAP
74 Kinetic analyses,
independent exchange and crossover exp
75 Kinetic analyses indicate 4-aminobenzoate and 4-hydroxyb
76 In-depth
kinetic analyses indicate a wide range of accessible mac
77 Our phenotypic, metabolomic, and
kinetic analyses indicate at least three modes of discri
78 Kinetic analyses indicate one open and two distinct clos
79 In addition,
kinetic analyses indicate that although both AtAtg4s hav
80 Computational and
kinetic analyses indicate that competing mechanisms invo
81 Transport assays and
kinetic analyses indicate that Git3 has the greater tran
82 Kinetic analyses indicate that manganese increases the r
83 Kinetic analyses indicate that PFAAs undergo (3 + 2) cyc
84 Steady state
kinetic analyses indicate that Poliota is 100 fold more
85 Presteady-state
kinetic analyses indicate that Q509L does not affect ini
86 While
kinetic analyses indicate that the enzyme was more effic
87 Kinetic analyses indicate that the sigmoidal behavior of
88 Kinetic analyses indicate that two mutations, P551S and
89 Our disaggregation landscape and
kinetics analyses indicate that tetramers probably act a
90 The dissociation constants and
kinetic analyses indicated roles for the arginines in tr
91 Steady-state
kinetic analyses indicated that Poliota and Poltheta ins
92 Kinetic analyses indicated that the (Q123K) variant had
93 Kinetic analyses indicated that the PCBP-5' cloverleaf R
94 amma-thialysine-73 variant and the attendant
kinetic analyses,
investigation of the protonation state
95 bstantiated by product distribution studies,
kinetic analyses,
LFERs, Rehm-Weller estimations of Delt
96 Results from
kinetic analyses,
microtubule (MT) binding competition a
97 Biodistribution and
kinetic analyses of (11)C-donepezil time-activity curves
98 Kinetic analyses of (124)I-2'-fluoro-2'-deoxy-1-beta-D-b
99 we performed comprehensive thermodynamic and
kinetic analyses of 15 different proteins from the thior
100 results were validated with Michalis-Menten
kinetic analyses of 21 oligopeptide aminomethyl-coumarin
101 Kinetic analyses of a series of alternate nucleotides we
102 Interestingly, construction and
kinetic analyses of a series of UGT74F1/F2 chimeras have
103 The work here describes the
kinetic analyses of aluminum replacement for boron in a
104 ed on the basis of the crystal structure and
kinetic analyses of amino acid replacement variants.
105 Saturation
kinetic analyses of anisomycin-SERT activity reveal a se
106 Crystallographic and pre-steady state
kinetic analyses of antibody 34E4, which efficiently pro
107 Kinetic analyses of antiviral suppression of cell cultur
108 Kinetic analyses of Arg(241) and Arg(91) replacement var
109 Kinetic analyses of Asn202 variants showed substantial d
110 Steady-state
kinetic analyses of Asn276Asp revealed slightly diminish
111 Kinetic analyses of Asn73 variants were consistent with
112 The model is examined via
kinetic analyses of Asp10, Thr16, His20, and Lys76 site-
113 igh resolution crystal structures and enzyme
kinetic analyses of Bacillus DNA polymerase I large frag
114 Kinetic analyses of changes in transcript levels upon co
115 Steady-state
kinetic analyses of CHO cytoplasmic tyrosyl-tRNA synthet
116 Steady-state and transient
kinetic analyses of class I CysRS and ValRS, and class I
117 Biochemical and
kinetic analyses of CPD mutants indicate that InsP6 bind
118 Here, we performed formal cellular
kinetic analyses of CTL019 in a larger cohort of 103 pat
119 Kinetic analyses of cyclohexene epoxidation confirmed th
120 End-point and rapid
kinetic analyses of dark-grown seedling growth revealed
121 Kinetic analyses of DNA binding and ATPase activities an
122 omoter mutants forming long-lived complexes,
kinetic analyses of duplex and bubble templates, dimethy
123 sults of tryptophan fluorescence binding and
kinetic analyses of DXP synthase and propose a new model
124 r inhibition by pregnanolone sulfate we used
kinetic analyses of equilibrium single-channel currents
125 Kinetic analyses of femtosecond transient absorption dat
126 Steady-state and transient
kinetic analyses of glutaminyl-tRNA synthetase (GlnRS) r
127 Kinetic analyses of hypocotyl growth inhibition in respo
128 Kinetic analyses of LPGAT1 expressed in COS-7 cells show
129 Here, we present both crystallographic and
kinetic analyses of mutants designed to explore this iso
130 Kinetic analyses of mutants of Phe-259 or Thr-314 indica
131 Kinetic analyses of mutants with different amino acid su
132 Kinetic analyses of nine additional insert mutants revea
133 Kinetic analyses of NMR spectroscopic data support a two
134 oliota, we have carried out pre-steady-state
kinetic analyses of nucleotide incorporation opposite te
135 ed complex was suitable for pre-steady-state
kinetic analyses of polymerase activity.
136 Finally, we performed
kinetic analyses of progenitor activity after sublethal
137 Kinetic analyses of prothrombinase assembled with the mu
138 Steady-state
kinetic analyses of purified MERS-CoV and SARS-CoV PLpro
139 ing interface, together with native PAGE and
kinetic analyses of PZ binding to ZPI, that Tyr240 and A
140 Glycan microarray and
kinetic analyses of recombinant A(H7N9) HAs were perform
141 Our
kinetic analyses of reconstituted particles demonstrate
142 In contrast,
kinetic analyses of residues away from the RNA indicate
143 We present
kinetic analyses of seven inhibitors, whose crystal stru
144 Kinetic analyses of SHV-1 and three SHV R244 (-S, -Q, an
145 Kinetic analyses of SHV-1, R244S, R244Q, R244L, and R244
146 Kinetic analyses of site-directed mutants prompted by th
147 Using
kinetic analyses of site-specific mutants and molecular
148 oles were investigated for the first time by
kinetic analyses of site-specific replacement variants o
149 We performed detailed
kinetic analyses of specific steps in the hepatitis C vi
150 Using steady state and
kinetic analyses of tau polymerization at a variety of p
151 Such
kinetic analyses of the "drugged" molecular system will
152 Kinetic analyses of the bending signal revealed an off r
153 The combination of structural and
kinetic analyses of the constructed mutants proved to be
154 Kinetic analyses of the CXXC mutant proteins indicated p
155 solution NMR, isotopic labeling studies, and
kinetic analyses of the degenerate exchange of methane i
156 Kinetic analyses of the distribution of viral proteins i
157 Steady-state
kinetic analyses of the excision process revealed that E
158 Kinetic analyses of the measured time-activity curves yi
159 Detailed
kinetic analyses of the properties of selected inhibitor
160 Robust
kinetic analyses of the reaction mechanism are complicat
161 Quench-flow pre-steady-state
kinetic analyses of the reactions of Gram-negative APH(3
162 Kinetic analyses of the respective polyadenylation react
163 Steady-state
kinetic analyses of the selected AlsK and NanK variants
164 Kinetic analyses of the specificity of beta-PGM toward p
165 Transient
kinetic analyses of the variant-catalyzed reactions and
166 Kinetic analyses of the wild type and three variant Pta
167 established to perform detailed steady-state
kinetic analyses of these concurrent reactions.
168 Kinetic analyses of this comprehensive array of rHDL par
169 Kinetic analyses of vaginal infection with C. albicans i
170 The
kinetic analyses of variants combined with structural mo
171 In this paper, we report molecular
kinetic analyses of water spreading on hydrophobic surfa
172 Kinetic analyses of wild-type and chimeric E2s were perf
173 Kinetic analyses of wild-type SAD and several active sit
174 mixing experiments together with independent
kinetic analyses of ZPI-PZ and factor Xa-PZ-membrane com
175 Structural and folding
kinetics analyses of family members suggest that distort
176 Kinetics analyses of the oxidation by CcTET under neutra
177 Growth
kinetics analyses of various xenograft models showed the
178 Kinetic analyses offer informative insights about reacti
179 Second, Ala scanning and
kinetic analyses on residues in the SH2-catalytic domain
180 In this study, we performed
kinetic analyses on splenocytes of BALB/c mice that were
181 aryotic genomes previously determined by Cot
kinetic analyses (
Onchorynchus keta, Ilyanassa obsoleta,
182 Viral and cellular
kinetic analyses performed in HIV-infected adults have y
183 Structural and
kinetic analyses place PRL-1 in the family of dual speci
184 olding transition state structures and the 2
kinetic analyses presented can be used to assess the nuc
185 tructure of a lumiracoxib-COX-2 complex, the
kinetic analyses presented herein of the inhibition of m
186 V and TBR correlated with those derived from
kinetic analyses (
r(2) = 0.83-0.97, P < 0.001, slope = 0
187 This article presents a number of
kinetic analyses related to binding processes relevant t
188 alytic activity and detailed biochemical and
kinetic analyses reported here will be of great value in
189 Structural and
kinetic analyses reveal a novel-peptide clamping mechani
190 Our
kinetic analyses reveal a reaction order of 1 in iodine,
191 In vitro
kinetic analyses reveal that CocE-L169K/G173Q displays a
192 Kinetic analyses reveal that inhibition is competitive w
193 Kinetic analyses reveal that modified nucleotides such a
194 Indeed, global
kinetic analyses reveal that NTE-Abeta42s form fibrils v
195 Single-channel
kinetic analyses reveal that open-time distribution of R
196 Kinetic analyses reveal that SSA impedes the A to B comp
197 Kinetic analyses reveal that synapsis occurs rapidly, fo
198 Kinetic analyses reveal that the growing polymer chain a
199 Ligand complex structures and
kinetic analyses reveal that the N terminus governs the
200 In vitro
kinetic analyses reveal that WT GluRS2 selectively acyla
201 Strikingly, pre-steady-state
kinetic analyses reveal that, although human DNA polymer
202 ermal titration calorimetry and stopped-flow
kinetic analyses reveal uncoupled nucleotide affinity an
203 Furthermore,
kinetic analyses reveal uniformity in the rates of subst
204 logical complex (piccolo NuA4), steady-state
kinetic analyses revealed a kinetic mechanism that requi
205 Kinetic analyses revealed a two-step, ping-pong, zinc-hy
206 Enzyme
kinetic analyses revealed that a number of these product
207 Kinetic analyses revealed that both lipids increase the
208 Detailed
kinetic analyses revealed that chloroquine and quinine c
209 Subsequent detailed
kinetic analyses revealed that loss of WRKY33 function r
210 Transient
kinetic analyses revealed that mavacamten modulates mult
211 Steady-state
kinetic analyses revealed that Mn(2+) increases the cata
212 Pre-steady-state
kinetic analyses revealed that PMEO-DAPym-pp is a good s
213 Kinetic analyses revealed that prelatent antithrombin is
214 Comparative enzyme
kinetic analyses revealed that single substitutions are
215 Steady state
kinetic analyses revealed that successive truncation of
216 Kinetic analyses revealed that TgTrx-Px1 is inhibited by
217 Kinetic analyses revealed that the allosterically regula
218 Single-channel
kinetic analyses revealed that the mean burst and interb
219 Single channel
kinetic analyses revealed that the mean open time of the
220 Kinetic analyses revealed that the mechanism responsible
221 Kinetic analyses revealed that the mutations in tRNA(Pyl
222 Kinetic analyses revealed that the specific activity, k(
223 Enzyme
kinetic analyses revealed that the structural features o
224 Detailed
kinetic analyses revealed that tryptophan substitution a
225 Kinetic analyses revealed these mutations minimally affe
226 Site-specific mutagenesis and steady-state
kinetic analyses revealed two critical catalytic residue
227 Motility data, as well as
kinetic analyses,
revealed impairment of the force-gener
228 Kinetic analyses show a pH dependence of ligand binding
229 sociation rate for O2 by both nmHO and paHO,
kinetic analyses show an increase in dissociation rate f
230 iferase activity, real-time quantitative and
kinetic analyses show that donor-derived muscle stem cel
231 Kinematic and
kinetic analyses show that even on hard surfaces, barefo
232 Kinetic analyses show that Gun4 dramatically increases t
233 Kinetic analyses show that in the absence of IL-12 there
234 Spectral, chromatographic, and
kinetic analyses show that the aerobic reaction of nikD
235 Kinetic analyses show that the apparent first-order rate
236 Kinetic analyses show that Treg expansion is not a conse
237 Kinetic analyses showed that CoA is a strong feedback in
238 Enzymatic
kinetic analyses showed that cryptotanshinone was a mixe
239 Kinetic analyses showed that RNA unwinding, not cleavage
240 Kinetic analyses showed that SIKE not only inhibits IRF3
241 Kinetic analyses showed that TgPhyA has similar properti
242 Rapid
kinetic analyses showed that the reaction proceeded by t
243 n epicatechin was used as a model inhibitor,
kinetic analyses showed that this catechol-containing di
244 ased sensitivity to the drugs, and transient
kinetic analyses showed that this hypersusceptibility wa
245 Kinetic analyses showed time-dependent inhibition, a hal
246 Rapid
kinetics analyses showed that the mutation minimally aff
247 drug block of Kv11.1 gained though detailed
kinetic analyses such as this have a potential role in d
248 Spectroscopic data and
kinetic analyses suggest a model in which a molecule of
249 These
kinetic analyses suggest that copolymerizing a macromono
250 Kinetic analyses suggest that these inhibitors bind afte
251 Kinetic analyses suggest that tyrosine nitration facilit
252 ced AR spreads over 30 min in the mouse, and
kinetic analyses suggest the presence of different sperm
253 Kinetic analyses suggested that ifenprodil prevents the
254 Both the phylogenetic and
kinetic analyses support the conclusion that all TGTs ha
255 Structural and
kinetic analyses support the identification of Asp13 as
256 Steady-state
kinetic analyses supported the results obtained from the
257 ifugation, X-ray crystallography, and enzyme
kinetic analyses that DAP epimerase from Escherichia col
258 ervations, when considered with accompanying
kinetic analyses that demonstrate cooperativity between
259 stinct activity profiles are correlated with
kinetic analyses that reveal that the ebvIL-10 dimer is
260 Here we describe a novel
kinetics analyses that maps out the nonlinear dependence
261 esults confirmed previous thermodynamics and
kinetics analyses that suggested that the disruption of
262 tion with light-scattering, fluorescence and
kinetic analyses,
that the SH3 domain facilitates the bi
263 w using crystal structure, thermodynamic and
kinetic analyses,
that this natural antibiotic employs a
264 in addition to their use in transient state
kinetic analyses,
the computational approaches applied h
265 We have extended our
kinetic analyses to a high-fidelity polymerase, Klenow f
266 Here we used mutagenesis and enzyme
kinetic analyses to address these gaps in knowledge.
267 tance of the application of in vivo cellular
kinetic analyses to characterize clinical efficacy and C
268 We combine structural and
kinetic analyses to identify mechanisms that contribute
269 ere we used steady-state and presteady-state
kinetic analyses to investigate the mechanism of action
270 ith surface plasmon resonance imaging to add
kinetic analyses to measured binding interactions.
271 sed double mutant cycles and presteady-state
kinetic analyses to probe the putative interaction betwe
272 n shown by NMR spectroscopy and quantitative
kinetic analyses to undergo quantitative conversion to t
273 The steady-state
kinetic analyses under aerobic and anaerobic conditions
274 Kinetic analyses under single-turnover conditions reveal
275 Reaction
kinetic analyses using (19)F NMR and density functional
276 troscopic studies ((29)Si and (31)P NMR) and
kinetic analyses using a rapid-injection NMR apparatus (
277 Additional
kinetic analyses using both the natural and unnatural su
278 Kinetic analyses using purified 40S subunits revealed a
279 Kinetic analyses using R- and S-HPC as substrates reveal
280 Kinetic analyses using stopped-flow spectroscopy reveale
281 Using quantitative
kinetic analyses,
we demonstrate that each component of
282 Using steady-state FRET, anisotropy, and
kinetic analyses,
we demonstrate that start codon recogn
283 g droplet-microfluidic technology and growth
kinetic analyses,
we demonstrate the presence of ibrutin
284 Using molecular modeling and binding
kinetic analyses,
we found that the strict spatial confi
285 Using site-directed mutagenesis and
kinetic analyses,
we show here that Ala657 and five cons
286 Combining structural and
kinetic analyses,
we show that (p)ppGpp binds the GMK ac
287 Using NMR spectroscopy and
kinetic analyses,
we show that yeast Dcp2 resolves inter
288 Model-independent and global
kinetic analyses were applied to simulate the RNAP II me
289 Kinetic analyses were completed using in vitro assays wi
290 Enzyme
kinetic analyses were conducted to determine the Km and
291 unequal length arms (7/11 nucleotides), and
kinetic analyses were performed to identify the most cat
292 Viral and cellular
kinetic analyses were performed using a nonlinear mixed-
293 he mechanism of activation, biochemical, and
kinetic analyses were performed with Lys-290 variants of
294 Confocal fluorescence microscopy and uptake
kinetic analyses were used here to characterize cells tr
295 Structural and
kinetic analyses were used to investigate the role of fl
296 yll fluorescence induction and Q(A)(-) decay
kinetics analyses were performed.
297 been investigated by using spectroscopic and
kinetic analyses with betaine aldehyde and its isosteric
298 rs were determined by combining isotopic and
kinetic analyses with density functional theory estimate
299 Kinetic analyses with several fatty acid hydroperoxides
300 Steady-state
kinetic analyses with the alternate disulfide substrates