ライフサイエンスコーパス: kinetic isotope effect

1 d us to measure the apparent large intrinsic kinetic isotope effect.

2 re limit of the reaction rate and by the H/D kinetic isotope effect.

3 th temperature and exhibit a large, primary, kinetic isotope effect.

4 e or temperature dependence of the intrinsic kinetic isotope effect.

5 f 19 kJ mol(-1) and a approximately 2.5-fold kinetic isotope effect.

6 ence of suppression of the intrinsic maximum kinetic isotope effect.

7 incorporation into biomolecules and minimal kinetic isotope effect.

8 ics, revealing a large temperature-dependent kinetic isotope effect.

9 and buffer concentration and have weaker H/D kinetic isotope effects.

10 n of both the thermal rate constants and the kinetic isotope effects.

11 ical calculations and by examining secondary kinetic isotope effects.

12 c solvent effects, Arrhenius parameters, and kinetic isotope effects.

13 Primary deuterium kinetic isotope effects (1 degrees DKIE) on (kcat/KGA, M

14 we found a marked increase of apparent (13)C-kinetic isotope effects ((13)C-AKIE) and decrease of 4-C

15 Calculated carbon apparent kinetic isotope effects ((13)C-AKIE) fell with 1.005 to

16 lement the analysis of competitive oxygen-18 kinetic isotope effects ((18)O KIEs) upon consumption of

17 l) and aqueous O2 consumption, derived (18)O-kinetic isotope effects ((18)O-KIE) for the reactions of

18 cently reported abnormal secondary deuterium kinetic isotope effects (2 degrees KIEs) for hydride tra

19 h pH-rate profiles, pKa and DeltaS() values, kinetic isotope effects ((2)H, (10)B, (13)C), linear fre

20 nalysis based on the measurement of multiple kinetic isotope effects.(36)S-labeled l-methionine and S

21 Cleavage at U exhibits a large 5' deuterium kinetic isotope effect, a potential signature of a base

22 l(-) concentrations induces a large apparent kinetic isotope effect (AKIE = 1.010-1.018) likely assoc

23 The corresponding apparent kinetic isotope effects (AKIE) for ipso-hydroxylation we

24 f the Rayleigh approach to evaluate apparent kinetic isotope effects (AKIE) was confirmed.

25 The apparent 15N kinetic isotope effects (AKIE) were almost identical for

26 Apparent kinetic isotope effects (AKIEs) of 1.0070 +/- 0.0002 (13

27 the corresponding (13)C- and (15)N-apparent kinetic isotope effects (AKIEs) of four nitrophenol-biod

28 Carbon and chlorine apparent kinetic isotope effects (AKIEs) were in general agreemen

29 ), derived apparent (13)C-, (2)H-, and (15)N-kinetic isotope effects (AKIEs), and characterized react

30 ent position on the apparent (13)C and (15)N kinetic isotope effects (AKIEs).

31 A kinetic simulation including kinetic isotope effects allowed determination of the pri

32 (3)H alpha-secondary kinetic isotope effect (alpha-SKIE) measurements of two

33 The results of kinetic isotope effect and structural studies indicate r

34 Both the [4-(2)H]NADH (NADD) kinetic isotope effect and the D2O solvent isotope effec

35 Significant deuterium kinetic isotope effects and a positive correlation of se

36 Taken together, the reported kinetic isotope effects and computational modeling are c

37 s of the anomalous temperature dependence of kinetic isotope effects and computational simulations.

38 to -20 degrees C, as inferred from measured kinetic isotope effects and corresponding electronic-str

39 and second order in [catalyst], while large kinetic isotope effects and group 2 element-dependent De

40 ch and that mechanistic experiments, such as kinetic isotope effects and kinetic solvent effects, are

41 at residues Thr169, His548, and Asn593, and kinetic isotope effects and pH-dependence studies of the

42 Previous mechanistic studies, including kinetic isotope effects and product inhibition, are disc

43 consistent with the experimentally measured kinetic isotope effects and reconciles the discrepancies

44 studied using a combination of experimental kinetic isotope effects and theoretical calculations.

45 Mossbauer spectroscopy, kinetic isotope effect, and gas adsorption measurements

46 Isotopic-labeling experiments, kinetic isotope effects, and computational studies clear

47 asurements, kinetic competition experiments, kinetic isotope effects, and hydrogen atom transfer reag

48 experimentally observed rate law, deuterium kinetic isotope effects, and identification of the catal

49 nsertion, as supported by reaction kinetics, kinetic isotope effects, and isotopic labeling studies.

50 Catalytic rate laws, kinetic isotope effects, and spectroscopic data show tha

51 ation with linear free-energy relationships, kinetic isotope effects, and stoichiometric experiments,

52 d study of linear free energy relationships, kinetic isotope effects, and the first quantitative expe

53 Evaluation of reaction kinetics, isotope effects, and commitment-to-catalysis b

54 rgy (E(a) = 0.46 +/- 0.05 eV) and strong H/D kinetic isotope effect (approximately 6).

55 imately 100 micros; E(a) = 0.34 +/- 0.08 eV; kinetic isotope effect, approximately 3); however, the p

56 Different reaction rates resulting from the kinetic isotope effect are observed.

57 Herein we show that unusually large chlorine kinetic isotope effects are associated with reactions in

58 isolated complexes, deuterium labeling, and kinetic isotope effects are consistent with a catalytic

59 The experimental and calculated kinetic isotope effects are consistent with an SN2 chemi

60 diffusion-limited experiments, we show that kinetic isotope effects are indeed consistent with publi

61 Both solvent O-H and substrate C-H deuterium kinetic isotope effects are observed for these reactions

62 ized, and expressions for rate constants and kinetic isotope effects are provided.

63 Gas-phase rate constants and kinetic isotope effects are reported for a variety of su

64 Kinetic isotope effects arising from deuterium-for-hydro

65 This indicates a very large kinetic isotope effect, as expected for a tunneling reac

66 ric intermediate decays with a large solvent kinetic isotope effect, as expected when proton delivery

67 to the mechanism by examining the deuterium kinetic isotope effect associated with the hydrogen tran

68 Here, we report a large kinetic isotope effect associated with the rate-limiting

69 t generally tended to be negative due to the kinetic isotope effect associated with thermal NOx produ

70 We report a large kinetic isotope effect at 298 K, kH/kD approximately 150

71 general method for the measurement of (13)C kinetic isotope effects at natural abundance for reactio

72 on ((12)C/(14)C) and secondary ((1)H3/(3)H3) kinetic isotope effects at the transferred methyl group,

73 dramatic, order-of-magnitude-strong, quantum kinetic isotope effect by measuring the absolute Penning

74 Measurements of reaction rates and carbon kinetic isotope effects (CKIE) for decarboxylation of is

75 hat the phenolic proton exhibits a secondary kinetic isotope effect, consistent with the calculations

76 ylide was studied by a combination of (13)C kinetic isotope effects, conventional calculations, and

77 nated by NH(4)(+), in combination with known kinetic isotope effects, could lead to eukaryotic biomas

78 A combination of kinetic isotope effects, crossover experiments, and comp

79 Chlorine kinetic isotope effects exceeding semiclassical limits w

80 (DFT) computational studies and results of a kinetic isotope effect experiment.

81 Deuterium labeling and kinetic isotope effect experiments indicate that C-H act

82 Kinetic isotope effect experiments suggest that hydroami

83 Moreover, solvent kinetic isotope effect experiments using deuterium oxide

84 mbination of structural, stereochemical, and kinetic isotope effect experiments.

85 ensive mechanistic studies showed an inverse kinetic isotope effect, fast H2/D2 scrambling and slow a

86 (3) H at their benzylic C atoms, owing to a kinetic isotope effect favoring hydrogen abstraction fro

87 effect for CFC-11 apparently similar to the kinetic isotope effect for (abiotic) ZVI degradation.

88 Deuteration at C-3 produced a strong kinetic isotope effect for 3-hydroxylation but not 4-hyd

89 and, consistent with the theoretical maximum kinetic isotope effect for C-Cl bond cleavage.

90 A kinetic isotope effect for Compound I decay suggests tha

91 The enzyme kinetic isotope effect for hydride transfer was close to

92 tution did not change the solvent or primary kinetic isotope effect for proton abstraction, consisten

93 Kinetics studies determine a large kinetic isotope effect for the replacement of the transf

94 Computed values of the kinetic isotope effect for this step are inverse, consis

95 We report the kinetic isotope effects for (18)O within selenate during

96 A comparison of the apparent kinetic isotope effects for aniline and diphenylamine di

97 Other studies included kinetic isotope effects for both dissociation and H exch

98 Here, we measured intrinsic kinetic isotope effects for both N23PP and N23PP/G51PEKN

99 psilonbulk values were converted to apparent kinetic isotope effects for carbon (AKIE) in order to ch

100 For the first time, kinetic isotope effects for carbon-to-metal hydrogen ato

101 rmining step, and substantial differences in kinetic isotope effects for different substrates; both t

102 The calculated kinetic isotope effects for p-nitrophenyl phosphate prov

103 Solvent kinetic isotope effects for Ser-Tyr-AMC were found to be

104 This result was further confirmed by primary kinetic isotope effects for which saturating with alphaK

105 In addition, the deuterium kinetic isotope effect from reactions of cyclohexane and

106 Second, the primary kinetic isotope effects from deuterated nicotinamide nuc

107 Primary kinetic isotope effects from substrate conversion measur

108 Kinetic isotope effects from the use of deuterated buffe

109 A large substrate kinetic isotope effect (>/=8) for OleT compound I decay

110 Experimental (13)C kinetic isotope effects have been used to interrogate th

111 For Pd/NZVI, the solvent kinetic isotope effect [i.e., kobs(H2O)/kobs(D2O) or SKI

112 The lack of electronic and kinetic isotope effects implies a rate-determining phosp

113 rrent study presents the first-ever observed kinetic isotope effect in a metal combustion reaction an

114 constrain ab initio calculations, making the kinetic isotope effect in the cold regime necessary to r

115 The secondary deuterium kinetic isotope effect in the reaction leading to comple

116 Kinetic isotope effects in AdoMet-dependent methyltransf

117 esults suggest a large difference in the H/D kinetic isotope effects in nitrogen and argon matrices (

118 ived temperature dependence of the anomalous kinetic isotope effects in ozone formation then provide

119 dolase reaction, and the analysis of solvent kinetic isotope effects in steady-state and pre-steady-s

120 The comparison of experimental and predicted kinetic isotope effects in the alpha-cleavage of alkoxy

121 Computed activation parameters and kinetic isotope effects, in combination with proton-inve

122 Escherichia coli (EcDHFR), where the enzyme kinetic isotope effect increased slightly with increasin

123 The deuterium kinetic isotope effect increases to 3.2, consistent with

124 e negative entropy of activation and inverse kinetic isotope effect indicate that H-H bond formation

125 Kinetic isotope effects indicated that the C-H bond clea

126 ition of Bronsted acids reveal a primary H/D kinetic isotope effect, indicating that transfer of prot

127 tion in substrate U is deuterated, a primary kinetic isotope effect is observed, which indisputably i

128 the methylene group, a significant apparent kinetic isotope effect is only found in the reductive pe

129 echanisms of these processes using kinetics, kinetic isotope effects, isotopic labeling experiments,

130 The kinetic isotope effect k(CH3)/k(CT3) for methyl transfer

131 ts, including measurement of a large primary kinetic isotope effect (k(H)/k(D) = 8.1 +/- 1.7), agree

132 Here we compare the PCET rates and kinetic isotope effects (k(H)/k(D)) of four Ru-TyrOH mol

133 ata for the reaction of ClSiH with Me(3)SiH, kinetic isotope effects, k(D)/k(H), in the range from 7.

134 A large kinetic isotope effect (kH/kD = 20) suggests proton coup

135 The observed kinetic isotope effect (KIE = kH/kD) ranged from 1.2 to

136 Here, we describe coordinated kinetic isotope effect (KIE) analyses, molecular dynamic

137 state of phosphoroimidazolide hydrolysis by kinetic isotope effect (KIE) and linear free energy rela

138 Kinetic isotope effect (KIE) experiments revealed that t

139 hensive labeling studies, rate measurements, kinetic isotope effect (KIE) experiments, synthetic stud

140 In concert with kinetic isotope effect (KIE) experiments, these computat

141 abstraction is overall-rate-determining [the kinetic isotope effect (KIE) for 1-d(1) conversion to 2

142 An unusual intramolecular kinetic isotope effect (KIE) in the reaction of dichloro

143 pecies with nine hydrocarbons shows that the kinetic isotope effect (KIE) involves strong tunneling a

144 An unusual H/D kinetic isotope effect (KIE) is described, in which isot

145 endent below approximately 10 K, and a large kinetic isotope effect (KIE) is observed upon substituti

146 The kinetic isotope effect (KIE) is used to experimentally e

147 Hammett analysis, radical clock experiments, kinetic isotope effect (KIE) measurements (kH/kD = 3.0 +

148 Kinetic isotope effect (KIE) measurements are a powerful

149 edia has been studied by the use of multiple kinetic isotope effect (KIE) measurements in conjunction

150 in order to characterize, by use of multiple kinetic isotope effect (KIE) measurements, the glycosyla

151 To characterize, by use of multiple kinetic isotope effect (KIE) measurements, the TS for th

152 The kinetic isotope effect (KIE) observed for doubly labeled

153 mechanism with kET = 2.7 x 10(7) s(-1) and a kinetic isotope effect (KIE) of 0.99 +/- 0.03.

154 SO(2)(-) and TpT exhibits a V(max) deuterium kinetic isotope effect (KIE) of 1.7 +/- 0.2, which is sm

155 he acetonitrile/water solvent mixture; a H/D kinetic isotope effect (KIE) of 2.0 +/- 0.4 is associate

156 An H/D kinetic isotope effect (KIE) of 80 is found at -20 degre

157 The rate and kinetic isotope effect (KIE) on proton transfer during t

158 However, a kinetic isotope effect (KIE) on the rate of binding is o

159 Furthermore, multiple kinetic isotope effect (KIE) studies revealed a stepwise

160 oacylation did not exhibit a significant H/D kinetic isotope effect (KIE) with respect to the aldehyd

161 We used kinetic isotope effect (KIE), commitment factor (Cf), an

162 test these two possibilities using secondary kinetic isotope effect (KIE), mutagenesis study, and pri

163 behavior and large but temperature-dependent kinetic isotope effects (KIE 32 at -40 degrees C).

164 upled electron-transfer mechanism; large H/D kinetic isotope effects (KIE) are observed.

165 that precludes calculation of apparent (2)H-kinetic isotope effects (KIE) as well as the process ide

166 r hydrogen has been shown to lead to massive kinetic isotope effects (KIE) for soybean lipoxygenase (

167 Significant kinetic isotope effects (KIE) were observed with a facto

168 through analysis of kinetic competition and kinetic isotope effects (KIE): (i) a mechanism dominatin

169 Tunneling-corrected kinetic-isotope effect (KIE) calculations matched the ex

170 helium temperatures and shows a rather large kinetic isotope effect, KIE = 10.

171 tate, and ligand binding kinetics, intrinsic kinetic isotope effects (KIEint) on the chemical step, a

172 the temperature-dependence of the intrinsic kinetic isotope effects (KIEs) and other kinetic paramet

173 neling reactions, as a result of its unusual kinetic isotope effects (KIEs) and their temperature dep

174 Kinetic isotope effects (KIEs) and their temperature dep

175 studied using a combination of experimental kinetic isotope effects (KIEs) and theoretical calculati

176 Primary kinetic isotope effects (KIEs) are modestly increased fo

177 Kinetic isotope effects (KIEs) are nearly temperature-in

178 Deuterium kinetic isotope effects (KIEs) are reported for the firs

179 ng the TS using a suite of five experimental kinetic isotope effects (KIEs) as constraints for the ca

180 t of [Formula: see text]-secondary deuterium kinetic isotope effects (KIEs) at all sites of [Formula:

181 and iPr(2)N horizontal lineBH(2) allowed the kinetic isotope effects (KIEs) attending the hydrogen tr

182 A new method is presented for measuring kinetic isotope effects (KIEs) by (1)H-detected 2D [(13)

183 (EIEs), binding isotope effects (BIEs), and kinetic isotope effects (KIEs) for a range of phosphate

184 In contrast, the primary kinetic isotope effects (KIEs) for C-H activation and th

185 Here the temperature dependence of kinetic isotope effects (KIEs) for hydride transfer betw

186 or distance (DAD) distribution and intrinsic kinetic isotope effects (KIEs) for the dihydrofolate red

187 tunneling, and the temperature dependence of kinetic isotope effects (KIEs) has emerged as the "gold

188 Ensemble-based measurements of kinetic isotope effects (KIEs) have advanced physical un

189 investigated with pH, solvent viscosity, and kinetic isotope effects (KIEs) in steady-state kinetics

190 The kinetic isotope effects (KIEs) in this enzyme have previ

191 ide insight into reaction mechanisms because kinetic isotope effects (KIEs) of both elements are refl

192 ay be generally applicable for examining the kinetic isotope effects (KIEs) of posttranslational modi

193 ter than that of the protiated form, causing kinetic isotope effects (KIEs) of ~1.3 on k(cat) and k(c

194 We performed transition state analysis using kinetic isotope effects (KIEs) on AroA-catalyzed EPSP hy

195 What do experimentally measured kinetic isotope effects (KIEs) tell us about H-abstracti

196 This method allows kinetic isotope effects (KIEs) to be determined with sub

197 C, H, and N isotope enrichment factors and kinetic isotope effects (KIEs) were derived from the com

198 The carbonyl-C, carbonyl-O, and leaving-S kinetic isotope effects (KIEs) were determined for the h

199 Solvent (D2O) and secondary formyl-H kinetic isotope effects (KIEs) were measured by an NMR s

200 Multiple kinetic isotope effects (KIEs) were measured for acid-ca

201 can be established by matching experimental kinetic isotope effects (KIEs) with theoretical predicti

202 ilarity extended to the associated secondary kinetic isotope effects (KIEs), indicating very similar

203 this step with experimental data, as well as kinetic isotope effects (KIEs), supports this prediction

204 ntrast with previously reported inverse (<1) kinetic isotope effects (KIEs).

205 16Ala, together with deuterium oxide solvent kinetic isotope effects (KIEs).

206 s in N2O), enrichment factors (epsilon), and kinetic isotope effects (KIEs).

207 is of nicotinamide mononucleotide (NMN) from kinetic isotope effects (KIEs).

208 calculate intramolecular and intermolecular kinetic isotope effects (KIEs).

209 n can be addressed by measuring steady-state kinetic isotope effects (KIEs); however, their interpret

210 nvestigations with the aid of Hammett plots, kinetic isotope effects, labeled stereochemical probes,

211 Kinetic investigations as well as the kinetic isotope effect measured confirmed that the hydri

212 Here, a combination of kinetic isotope effect measurements and quantum chemical

213 kinetics, and natural abundance (12)C/(13)C kinetic isotope effect measurements.

214 The growing tool kit of kinetics, kinetic isotope effects, molecular biology, biophysics,

215 H(CD3)(SiMe3)](+) is used, suggesting an H/D kinetic isotope effect much larger (apparently >16,000)

216 c analysis coupled with the normal (13)(V/K) kinetic isotope effect observed on C-4 of oxaloacetate [

217 This conclusion was supported by the inverse kinetic isotope effect observed with deuterated 1S, the

218 nsistent with the observed inverse secondary kinetic isotope effect of 0.85.

219 A minimal kinetic isotope effect of 1.10(5) was observed, suggesti

220 dependence of the kinetics, and from a D2/H2 kinetic isotope effect of 1.2(+/-0.3).

221 a concerted PCET (tau = 4.7 mus) with an H/D kinetic isotope effect of 1.4 +/- 0.2.

222 This step shows a solvent kinetic isotope effect of 1.7.

223 e covalent thioimide reduction and a smaller kinetic isotope effect of 1.8 on the imine reduction to

224 mining attack at the THF C-H(D) bonds with a kinetic isotope effect of 10.2.

225 simulation reveal a large primary deuterium kinetic isotope effect of 3.3 on the covalent thioimide

226 es from experiments which identify a primary kinetic isotope effect of 5.4 for the deformylation reac

227 Reactions with deuterated acid display a kinetic isotope effect of 9 +/- 1.

228 The corresponding kinetic isotope effect of approximately 10 is attributed

229 erated species, giving rise to a significant kinetic isotope effect of approximately 50.

230 The latter proceed with a relatively small kinetic isotope effect of kH/kD = 7 for the iron(IV)-tos

231 A hydrogen/deuterium kinetic isotope effect of nearly 2 implicates O-H(D) bon

232 erivative that exhibits steady-state solvent kinetic isotope effects of 1.4 on both V and V/K.

233 Kinetic isotope effects of 1.5-2.3 (on kcat/Km ) were ob

234 Large primary deuterium kinetic isotope effects of 13.4 +/- 1.0 and 16.8 +/- 1.4

235 precursors; (b) obtain information about the kinetic isotope effects of as yet undescribed enzymes, t

236 d to their known precursors and to the known kinetic isotope effects of enzymes involved in their bio

237 Significant kinetic isotope effects of epsilon( per thousand) = -5.0

238 While the apparent (13)C- and (2)H-kinetic isotope effects of nitrobenzene, nitrotoluene is

239 These findings can (i) be related to known kinetic isotope effects of some of the enzymes concerned

240 Here the temperature-dependence of intrinsic kinetic isotope effects of the enzyme formate dehydrogen

241 or hydrogen at a ribose 5'-carbon produces a kinetic isotope effect on cleavage; the major cleavage p

242 The observed kinetic isotope effect on H atom versus D atom abstracti

243 The primary kinetic isotope effect on quinonoid intermediate formati

244 studies at short times show that there is no kinetic isotope effect on the initial step in the reacti

245 al for substantial benefits of the deuterium kinetic isotope effect on the safety and disposition of

246 is C-C "lyase" activity, we investigated the kinetic isotope effect on the steady-state turnover of N

247 We have measured delta-secondary kinetic isotope effects operating through four bonds for

248 Temperature-dependent measurements of the kinetic isotope effects over a 60 degrees C temperature

249 netic studies, H/D exchange experiments, and kinetic isotope effects provide clear support for a bime

250 transfer complex absorbance and experimental kinetic isotope effect reaction data, we show that this

251 Third, the apparent kinetic isotope effects related to the methyl group are

252 The unanticipated large kinetic isotope effects reported here for the tocopherol

253 Mechanistic studies especially using kinetic isotope effects show that cleavage by oxidative

254 h are subject to kinetic solvent effects and kinetic isotope effects similar to RSOH and other good H

255 -independent (pH 6.5), we determined solvent kinetic isotope effects (SKIEs) for three substrates who

256 , pre-steady-state time courses, and solvent kinetic isotope effects (sKIEs).

257 Product analysis, kinetic isotope effects, stereochemical labeling, radica

258 Kinetic isotope effect studies determine that the rate c

259 Kinetic isotope effect studies indicate that C-H pallada

260 Mass spectrometry and (1)H NMR based kinetic isotope effect studies revealed C-H bond activat

261 Furthermore, kinetic isotope effect studies support that the cis-amin

262 A series of secondary kinetic isotope effect studies using a range of ligands

263 temporal course of the reaction by (1)H NMR, kinetic isotope effect studies, and control experiments.

264 s that support these calculations, including kinetic isotope effect studies, H/D exchange studies, an

265 h other EPR and in situ IR spectroscopic and kinetic isotope effect studies, reveal that the steady-s

266 sulfur isotope-labeled substrates for sulfur kinetic isotope effect studies.

267 ans-Polayni graph and the finding of a large kinetic isotope effect suggest that hydrogen abstraction

268 Reaction progress kinetic analysis and kinetic isotope effects suggest that the stereodefining

269 ol pKa, and the absence of deuterium solvent kinetic isotope effects suggested stepwise mechanisms wi

270 urements) rule out a stepwise mechanism, and kinetic isotope effects support concerted proton-electro

271 ports an O-atom insertion mechanism, and H/D kinetic isotope effects support net hydride-transfer oxi

272 Carbon kinetic isotope effects supported a rate-determining AdE

273 eactivity constitutes the first example of a kinetic isotope effect that discriminates between the fo

274 d TEAH(+) displays a potential-dependent H/D kinetic isotope effect that is not observed for DIPEAH(+

275 ent bimolecular rate constants and deuterium kinetic isotope effects that increase in proportion to c

276 From the Arrhenius plot of the kinetic isotope effect, the ratio of the preexponential

277 n the basis of the small values of deuterium kinetic isotope effects, the relatively high and negativ

278 Furthermore, there is no solvent kinetic isotope effect throughout the temperature range

279 cts feature the strategic use of a deuterium kinetic isotope effect to improve the efficiency of a la

280 ns, isotopic incorporation from solvent, and kinetic isotope effects, to define the mechanism and an

281 ts biphasic decay kinetics with no deuterium kinetic isotope effect upon PhSD substitution.

282 The two variants provide nearly identical kinetic isotope effect values (2.8-3.0), suggesting that

283 ulations of commitment factors from observed kinetic isotope effect values support a hydride transfer

284 gating, we determined vibrational as well as kinetic isotope effects (VIEs and KIEs) of carboxylic gr

285 The kinetic isotope effect was determined to be 0.67 using 1

286 a bromopyrone, but a highly unusual, inverse kinetic isotope effect was evident using a chlorocoumari

287 The kinetic isotope effect was found to vary linearly with t

288 investigating the temperature dependence of kinetic isotope effects, we present evidence that the re

289 experiments, substrate analogs, and primary kinetic isotope effects, we show that the interaction be

290 Kinetic isotope effects were measured for the methylatio

291 y Me-(3)H3, Me-(2)H3, 5'-(14)C, and 5'-(3)H2 kinetic isotope effects were measured for the methylatio

292 Intramolecular (12)C/(13)C kinetic isotope effects were predicted to be substantial

293 The intrinsic kinetic isotope effects were used as boundary constraint

294 Experimental kinetic isotope effects were used to guide quantum mecha

295 including determination of the rate law and kinetic isotope effects, were utilized to identify a cha

296 he reaction is presented showing a lack of a kinetic isotope effect when generating deuterothiophenol

297 Calculations of kinetic isotope effects, when including the solute inter

298 f the intermediate ketols and on the solvent kinetic isotope effects, whereby the condensations are f

299 alyzed proton transfer shows a prominent H/D kinetic isotope effect, which is determined to be 8.3 x

300 tum tunnelling can give rise to experimental kinetic isotope effects with complex temperature depende