ライフサイエンスコーパス: kinetically

1 tinguished intermediate steps of degradation kinetically.

2 LC) can be used to correct these differences kinetically.

3 llowing the ligand binding and quantified it kinetically.

4 a poor H(+) donor both thermodynamically and kinetically.

5 des information on distance distributions of kinetically accessed intermediates of fast conformationa

6 cycloaddition to synthesize cyclobutanes is kinetically accessible by photochemical methods, but the

7 ion to ensure that the intended structure is kinetically accessible.

8 RNA synthesis and enhancer activation and is kinetically accompanied by the recruitment of ATR and th

9 ated and monodissociated anions of MH2Q were kinetically active species toward Fe(III) reduction, wit

10 y inert compounds) or pseudo-proton sponges (kinetically active) are discussed.

11 -1a:SNAP-25 complex on target membranes that kinetically alters the binding of synaptobrevin-2.

12 the mechanisms of factor action are defined kinetically and are consistent for both gene repression

13 Our recent report of Y356* formation in a kinetically and chemically competent fashion in the reac

14 , the growth of the z-AlN is ascribed to the kinetically and energetically favored nitridation of the

15 ent protein-unfolding machine than ClpA both kinetically and in terms of ATP consumed.

16 genase (Dd FDH) to reduce carbon dioxide was kinetically and mechanistically characterized.

17 ledge of the DNA-scanning process allows for kinetically and thermodynamically balanced engineering o

18 ds have been designed to stabilize otherwise kinetically and thermodynamically disfavored 6-membered

19 f 1,2,4-oxadiazolidin-5-ones is favored both kinetically and thermodynamically independently of the s

20 , to show that alternative conformations are kinetically and thermodynamically more readily accessibl

21 , which showed that in all cases C-attack is kinetically and thermodynamically preferred over O-attac

22 h pores, only partially lined by protein, be kinetically and thermodynamically stable?

23 (a) the chaperonin facilitates unfolding of kinetically and topologically trapped intermediates or (

24 colloids generally collide and stick forming kinetically arrested random aggregates when the thicknes

25 We show that a kinetically arrested state can be induced by randomly pi

26 nt rates during the solvent removal process, kinetically arresting the system, the period of the micr

27 with lower packing densities may be favored kinetically because the required energetic penalty is sm

28 , ketene, ethanol, acetylene, and ethane are kinetically blocked.

29 CHOH to form CH4 while C2 (C3) pathways are kinetically blocked; (2) at neutral pH, the C1 and C2 (C

30 as been extensively studied structurally and kinetically, but several key steps following phosphodies

31 of carbonate diesters has been investigated kinetically by applying the LFER equation log k = sf(Ef

32 DNA binder, and its unbinding is controlled kinetically by molecular stripping from the DNA induced

33 d thermodynamically by the nucleation, while kinetically by the enhanced Zn adsorption and O diffusio

34 aged disulfide structures, which can then be kinetically captured upon sulfur extrusion at room tempe

35 We kinetically characterize 2AMTA with human MTAP, bacteria

36 2AMTA was used as the substrate to kinetically characterize the dissociation constants for

37 homogeneous catalysis route is confirmed and kinetically characterized from SECM toward an insulating

38 The purified recombinant enzyme was kinetically characterized in the direction of UDP-glucos

39 peroxidase and the lignin macromolecule was kinetically characterized using stopped-flow spectrophot

40 M) and PDB databases, but the enzyme was not kinetically characterized.

41 Gastric and ileal chymes were kinetically collected over the postprandial period.

42 toinitiated electron-transfer reactions that kinetically compete with O(2)(a(1)Delta(g)) production.

43 The amyloidogenic aggregation would kinetically compete with the process of membrane permeat

44 esulting in a pre-organized ligand shell for kinetically competent and error-free photo-assembly of t

45 regates of nitro compounds and acids are the kinetically competent Bronsted acid catalysts.

46 Compound 2 is kinetically competent for breaking strong C-H bonds of a

47 les, this iron(0) species is not found to be kinetically competent for catalysis.

48 of the leaving group and therefore the most kinetically competent natural substrates.

49 The CT complex is formed at a kinetically competent rate by reaction with sulfide but

50 echanistic studies show that this complex is kinetically competent to be an intermediate in the catal

51 he substrate complexes are catalytically and kinetically competent to be intermediates in allylic sub

52 The observed Fe(4+) species are not kinetically competent to serve as the active site in wat

53 terized, and determined to be chemically and kinetically competent to undergo the proposed elementary

54 e intermediate is shown to be chemically and kinetically competent.

55 f supramolecular self-assembly by connected, kinetically competing enzymatic reactions.

56 nds profoundly on reaction conditions due to kinetically competing relevant elementary reaction steps

57 the guanines within the G-quadruplex that is kinetically competitive with the formation of GEAn(+*).

58 gen (N2) and reduction to ammonia (NH3) is a kinetically complex and energetically challenging multis

59 toward the donor site because its disruption kinetically compromises the ability of GlgE to extend po

60 cleotide (nt) tracts of microhomology, which kinetically confines the search to sites with a high pro

61 sive microscopic mechanism of doping-induced kinetically constrained crystallization in phase-change

62 s of DNA-coated microspheres are adjusted to kinetically control a higher-order hierarchical aggregat

63 facial electrocyclic mechanism, or through a kinetically controlled 5-endo-trig Mannich process.

64 Kinetically controlled AA' graphite exhibits unique nano

65 T becomes less prominent and eventually gets kinetically controlled at room temperature.

66 In bacteria, this process is kinetically controlled by three initiation factors--IF1,

67 Kinetically controlled catalytic cross-metathesis reacti

68 idinone-derived triazolium catalyst produces kinetically controlled chemoselectivity.

69 Experiments under kinetically controlled conditions reveal that this high

70 tal nanocrystals under thermodynamically and kinetically controlled conditions.

71 It is used to carry out a kinetically controlled covalent immobilisation of trypta

72 Kinetically controlled cross-linking processes produce m

73 The first examples of kinetically controlled cross-metathesis reactions that g

74 Upon drying, micelle aggregation and a kinetically controlled crystallization of central blocks

75 Illustrative examples of kinetically controlled E-selective cross-metathesis and

76 morph (by stringent exclusion of air) or the kinetically controlled formation of the high-pressure py

77 We demonstrate that a kinetically controlled heme-dependent metabolite switch

78 that the inclusion complexes are formed by a kinetically controlled mechanism involving a delicate in

79 This Tutorial Review focuses on the kinetically controlled phenomena that occur within DCLs.

80 Suggested incorporation processes are a kinetically controlled process, such as facilitated tran

81 observed self-sorting is a symmetry-driven, kinetically controlled process.

82 [1,5]H-shift (2 --> 4), thereby favoring the kinetically controlled product (3a-3j) as anticipated.

83 Burgess reagent induced formation of kinetically controlled product claulamine A, and intramo

84 3,5-dihydroxy cyclohexane derivatives as the kinetically controlled products via a domino aldol-aldol

85 plex due to spontaneous symmetry breaking or kinetically controlled random assembly formation.

86 ective and, according to DFT calculations, a kinetically controlled reaction.

87 allocation of DMSP between these pathways is kinetically controlled to release increasing amounts of

88 tracene analogue with five-membered rings is kinetically controlled while an "expected" product with

89 to dehydrate at all pH values, the presumed kinetically controlled yield of 17alpha-TBOH photohydrat

90 Kinetically controlled Z-selective RCM reactions have be

91 We demonstrate that AT secretion is a kinetically controlled, non-equilibrium process coupled

92 As a result, its presence is kinetically controlled, which gives the associated supra

93 The reactions are kinetically controlled.

94 electrolyte, and that ionic transport can be kinetically controlled.

95 of the tyrosine (Y215F, Y215H) were analyzed kinetically, crystallographically and by molecular dynam

96 plistic pursuit of high affinity can lead to kinetically deficient proteins that spend too much time

97 Several of the kinetically defined steps of BRD4 in this study are prop

98 nomeric to a fibrillar state via a series of kinetically defined steps.

99 on by acting at a minimum of three different kinetically defined steps.

100 We show that the kinetically-defined mechanism of action of each of four

101 re assessed using the CIELAB system and were kinetically described by a zero-order model.

102 of the Ir-catalyzed borylation of pyrene is kinetically determined and can be influenced to some ext

103 minimization tools when multiple structures, kinetically determined structures, or complex RNA-RNA an

104 ate allosteric model and instead is probably kinetically determined.

105 t latencies and similar amplitudes, but were kinetically different (i.e., faster in interneurons vs p

106 These features imply a more dynamic, kinetically discontinuous replication process, wherein c

107 , for flaps longer than 30 nucleotides, FEN1 kinetically discriminates substrates based on flap lengt

108 The success of the kinetically disfavored 5-endo cyclization was attributed

109 f some polyether natural products involves a kinetically disfavored epoxide-opening cyclic ether form

110 ng within the supramolecular cavity of 1, is kinetically disfavored in the absence of 1, as evidenced

111 , CH2O and HF, with the latter channel being kinetically disfavored.

112 ions, we have proposed a model incorporating kinetically distinct binding to the open and inactivated

113 tina proposed that an ordered arrangement of kinetically distinct bipolar cell inputs to ON- and OFF-

114 SBACs arise from the ordered arrangement of kinetically distinct bipolar cell inputs.

115 -biased opioid agonist, c) Identification of kinetically distinct conformational states to be used fo

116 glycol) hydrogels crosslinked with multiple, kinetically distinct dynamic metal-ligand coordinate com

117 oductive folding pathway and slowing several kinetically distinct folding transitions that occur insi

118 f hydrogel networks by utilizing mixtures of kinetically distinct reversible covalent crosslinks.

119 ected by pressure and occurs in at least two kinetically distinct steps.

120 del in which both naive T-cell pools contain kinetically distinct subpopulations of older host-derive

121 EVS activation engages several kinetically distinct synaptic processes that profoundly

122 s were well-predicted by linear summation of kinetically-distinct rod- and cone-mediated signals foll

123 provides mechanical force essential for all kinetically distinguishable forms of endocytosis at syna

124 The oxidative electron transfer is kinetically dominant as a result of the unusually strong

125 Chemical systems that remain kinetically dormant until activated have numerous applic

126 ransition there is a boost in activity for a kinetically driven reaction, ethylene epoxidation, givin

127 O proceeds in two consecutive, irreversible, kinetically driven steps with the apparent transition te

128 ing protein domains of filamin and titin are kinetically ductile when pulled from their two termini,

129 istribution of macrocycles can be controlled kinetically during the oxidation process or thermodynami

130 Here we show that kinetically E-selective cross-metathesis reactions may b

131 true molecularity, and hence the associated kinetically effective nucleus (KEN), for nanoparticle fo

132 , the experimentally-based concepts of (i) a kinetically effective nucleus and (ii) the concept of a

133 r weight and oligomeric carboxylic acids are kinetically equivalent at accelerating this isomerizatio

134 istry, is the lack of efficient methods that kinetically favor E isomers in the product distribution.

135 It provides a thermodynamically and kinetically favorable means to form aoQMs, independent o

136 vity for anti-Markovnikov oxidation over the kinetically favored alkene epoxidation by trapping high-

137 but metastable antiregistered phases can be kinetically favored by hydrophobic mismatch.

138 reference for the same cross-benzoin product kinetically favored by the piperidinone-derived catalyst

139 oviding synthetically useful quantities of a kinetically favored olefin isomer.

140 ons indicate that topotactic delithiation is kinetically favored over decomposition into Li, ZrO2, an

141 afast symmetry-breaking charge separation is kinetically favored over intramolecular excimer formatio

142 proton back leakage through the D-channel is kinetically favored over proton pumping due to the loss

143 This new path is kinetically favored over the direct amine-catalyzed alph

144 gy landscape reveals a lower barrier for the kinetically favored second cycloaddition compared with t

145 BNC, but that the former (i.e., pumping) is kinetically favored whereas the latter (i.e., transfer o

146 n Cre enhance commitment to recombination by kinetically favoring the formation of pre-synaptic compl

147 To identify kinetically favourable substrates we performed a GSK3 su

148 This anode reaction is, however, not kinetically favourable.

149 nce is that although the RRD reaction may be kinetically feasible at elevated temperatures, the produ

150 ly, the PPM1G-7SK RNA interaction is direct, kinetically follows the recruitment of PPM1G to promoter

151 n expressed sequence tag library), evaluated kinetically for its substrate/inhibitor profile and asse

152 und surfactant, leaving behind concentrated, kinetically frozen drug micelles containing minimal solu

153 n, despite conditions of supersaturation, is kinetically hindered at low temperatures for reasons tha

154 n = 3, fluoroform) through C-H activation is kinetically hindered under ambient conditions but might

155 tion of a chemically stable surface phase is kinetically hindered.

156 s of crystalline facets on seed nanocrystals kinetically; however, it was difficult to rationally pre

157 hat may potentially be thermodynamically and kinetically important during stationary gating.

158 populations, we can "visualize" a series of kinetically important intermediates, track the kinetics

159 n ionophore-based polymeric membranes can be kinetically improved by several orders of magnitude in c

160 Kinetically improved diacylglycerol acyltransferase (DGA

161 across the membrane/water interface, thereby kinetically improving voltammetric Na(+) selectivity aga

162 now been viewed (both thermodynamically and kinetically) in terms of the pressure dependence of the

163 (4) m(-1) s(-1)), and both Cys residues were kinetically indistinguishable.

164 al nitrogen organic bases as proton sponges (kinetically inert compounds) or pseudo-proton sponges (k

165 xchange reactions prior to oxidation and the kinetically inert metal-ligand bonds after oxidation, ro

166 The C-H bonds of methane are generally more kinetically inert than those of other hydrocarbons, reac

167 composes into LiH and B, with Li2B12H12 as a kinetically inhibited intermediate phase, (LiBH4)n nanoc

168 ratio depends on the reaction conditions and kinetically (KRs) or thermodynamically (TRs) controlled

169 By taking advantage of both the kinetically labile metal-ligand exchange reactions prior

170 erved following irradiation of 1 subset2a, a kinetically labile rotaxane was obtained on irradiating

171 water, oxidants and organic molecules could kinetically limit gas-particle interactions of SOA in th

172 demonstrate that the increased adsorption is kinetically limited and not experimentally observable on

173 ixing process for SOA and hexadecanol may be kinetically limited at shorter time scales.

174 energy (Eapp) of 56.5 (+/-5) kJ mol-1 and is kinetically limited by desorption of molecular CO from P

175 identify that the rate capability of LIBs is kinetically limited by the sluggish solid-state diffusio

176 tioning between particles and water appeared kinetically limited during the open water season.

177 In the kinetically limited regime, intermediate geometries that

178 sociated long equilibration times are due to kinetically limited surface reactions that result from l

179 the nuclueation of stishovite appears to be kinetically limited to 1.4+/-0.4 ns.

180 on is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current r

181 ggested that the regeneration process may be kinetically limited.

182 tent, we identify conditions yielding either kinetically locked or spontaneously transforming copreci

183 hat the heteroleptic palladium(II) cages are kinetically metastable intermediates rather than the the

184 lor-coded retinoblastoma cells allowed us to kinetically monitor tumor cell invasion and metastasis.

185 This reaction is also thermodynamically and kinetically more favourable than water oxidation.

186 ic site, bringing about less error-prone and kinetically optimized isoleucyl-tRNA(Ile) synthesis unde

187 th two s-cis or s-trans butadienes is either kinetically or thermodynamically unfavorable, and the 1Z

188 yrenebutyrate can accelerate this process to kinetically outcompete endosomal capture.

189 increases the fraction of folded proteins by kinetically partitioning more molecules through on-pathw

190 The obtained rac-LA is kinetically polymerized into poly(L-lactide) and optical

191 NDOR probes to test, detect, and corroborate kinetically predicted trends in active site reactivity a

192 Polymerization to cis-isomer is kinetically preferred at low temperature, not only in th

193 t the metal with each propagating step and a kinetically preferred diastereomeric relationship betwee

194 corroborated by deuterium labeling studies, kinetically preferred hydrometalation of the terminal ol

195 ion leading to the formation of sultines was kinetically preferred over the loss of sulfur dioxide le

196 alkenes reveal that phenylsilane is not the kinetically preferred reductant in many of these transfo

197 nly generate Z-olefins selectively, but also kinetically produce E-olefins, a previously unmet challe

198 hat evaporative helium cooling is capable of kinetically quenching the nonequilibrium tetramer system

199 Compound 3 is kinetically reactive and reacts in the microsecond time

200 etectable, indicating that the modifications kinetically regulate the velocity of surface transporter

201 Eosinophil CAR4 expression was kinetically regulated by IL-5, but not IL-13.

202 rdingly, models that assume HOBr is the only kinetically relevant brominating agent in solutions of f

203 led mechanistic studies were suggestive of a kinetically relevant C-H metalation by carboxylate assis

204 Turnover rates are lower and kinetically relevant species are less stable on Mo than

205 lently bound alkoxides form C-C bonds in the kinetically relevant step for dimerization turnovers on

206 direct involvement of reactive oxygen in the kinetically relevant step leads to more effective CH4 tu

207 tial C-H bond activation remains as the sole kinetically relevant step on Ni-Co, Ni, and Co clusters,

208 se have contributed to the alkylation in the kinetically relevant step.

209 bines theory and experiment to determine the kinetically relevant steps and site requirements for deo

210 mathematical simulations quantitatively and kinetically reproduced all experimental data.

211 and analyzed by the finite element method to kinetically resolve all steps of the ECadsCmag mechanism

212 atalytic C-O-bond cross-coupling strategy to kinetically resolve racemic diols with aromatic and alip

213 as well as trans-cycloalkane-1,2-diols were kinetically resolved, achieving high selectivities and g

214 fluorescence polarization (FP) spectroscopy, kinetically resolves the dissociation of detergents from

215 n products, is complicated by a multitude of kinetically reversible adducts, such as acetals and sulf

216 reduction through the thermodynamically and kinetically reversible reductive-elimination/oxidative-a

217 erall reaction that is thermodynamically and kinetically reversible.

218 l interest in relation to the development of kinetically selective adsorption separation processes.

219 ameters differ by less than an angstrom show kinetically selective organic liquid reverse osmosis.

220 ts demonstrate a general strategy to control kinetically self-assembly beyond thermodynamic products

221 In this study, we have introduced a kinetically sensitive dual-frequency designer waveform i

222 This material can kinetically separate ethylene from ethane with an unprec

223 d it is expected that this species should be kinetically short-lived.

224 e that C-H activation is both reversible and kinetically significant.

225 The reaction between ABAO and aldehydes is kinetically similar to oxime formations performed under

226 binding sites of plasmin(ogen) and is only a kinetically slow plasmin inhibitor.

227 y remain in an off-state long enough for the kinetically slower epigenetic silencing mechanisms to ac

228 ure energy demands, but often limited by the kinetically sluggish hydrogen evolution reaction (HER) o

229 he transcription factor for the DNA but also kinetically speeds DNA release.

230 rugs, bind directly to tubulin subunits and "kinetically stabilize" microtubules, suppressing the cha

231 favorable core-shell Ag@Au nanostructure is kinetically stabilized by the intermediate Ag20 shell, p

232 a precursor that does not crystallize to the kinetically stabilized product.

233 We produced kinetically stabilized Rous sarcoma virus (RSV) intasome

234 nocrystal morphologies to the development of kinetically stabilized surface features and demonstrates

235 ort the emulsion of nuclear bodies, but only kinetically stabilizes them by slowing down gravitationa

236 able air-stable dimeric dopant can result in kinetically stable and efficient n-doping of host semico

237 whereas non-amyloidogenic LC dimers are more kinetically stable and resistant to endoproteolysis.

238 we describe the development of an unusually kinetically stable chemical hydrogen storage material wi

239 ns can rearrange following electrospray into kinetically stable gas-phase conformations).

240 zing the formation of structurally distinct, kinetically stable integrase-DNA product complexes, depe

241 he pH of the solution, yielding a relatively kinetically stable molecule.

242 Under these conditions, the compounds are kinetically stable over long time periods (>100 days).

243 have been employed to describe a variety of kinetically stable polyionic molecular species that are

244 l flow readily unfolds thermodynamically and kinetically stable proteins, exposing previously sequest

245 CLAmP was designed to form kinetically stable tetrahedral intermediates upon the ad

246 ing; both modern RNases H evolved to be more kinetically stable than their most recent common ancesto

247 -soluble platinum(IV) prodrugs, which proved kinetically stable to reduction in the presence of physi

248 r reduction by one electron path, leaving it kinetically stable to the vast majority of organic cellu

249 Monothioarsenate is kinetically stable under a wide range of pH and redox co

250 hat PtO4 (2+) has a metastable state that is kinetically stable with a barrier height for decompositi

251 ion and characterization of high-energy, but kinetically stable, intermediates: (1) donor-donor inter

252 existence of these "cross" supermicelles as kinetically stable, micron-size colloidally stable struc

253 celerates dissociation of unloaded bonds and kinetically strengthens strained bonds.

254 Polar environments lead to a kinetically stronger, shorter, and more polar bond betwe

255 PHD isoform, is proposed to be biochemically/kinetically suited as a hypoxia sensor due to its relati

256 s show that nonnative salt bridges stabilize kinetically the encounter complex during binding.

257 We have investigated immunochemically and kinetically the occurrence of CatC and its proform in hu

258 and mass evaporation effects are controlled kinetically/thermodynamically.

259 roximately 0.1 s, a transition occurs from a kinetically to a largely thermodynamically controlled di

260 y but, contrary to expectation, microH+ acts kinetically to control the rate of the process.

261 rdinate expression of c-MYC, which is linked kinetically to that of PRC in response to multiple stres

262 a proton wire can act as a 'tunnel diode' to kinetically trap protons and control the direction of pr

263 desired shape, but misfolded structures can kinetically trap the system and reduce the yield.

264 In the past decade, the focus has shifted to kinetically trapped (non-dissipative non-equilibrium) st

265 med by self-assembly can be characterized as kinetically trapped 3D networks of fibrils.

266 Stable liposomes are typically kinetically trapped and are not prone to exchanging diac

267 nected structures of two immiscible liquids, kinetically trapped by colloidal particles that are irre

268 dynamics is much slower due to formation of kinetically trapped conformations caused by long-lived n

269 around an oligomethylene chain, as part of a kinetically trapped entanglement.

270 Thus, the monomers of these PBIs are kinetically trapped in conformationally restricted state

271 ggest that VIR165-dependent Env proteins are kinetically trapped in the unliganded state and require

272 resent work, the structural interrogation of kinetically trapped intermediates of cyt c was performed

273 misfolding trajectories leading to distinct kinetically trapped misfolded conformations.

274 ucidate the periodic crystallisation and the kinetically trapped morphology at a mesoscopic level.

275 ion of the branched micellar structures as a kinetically trapped morphology.

276 The example reported here illustrates that kinetically trapped products may facilitate high yields

277 e observed nonclassical fullerene could be a kinetically trapped species derived from the recently re

278 the conformational search, we find that the kinetically trapped species have a trans-trans configura

279 A kinetically trapped state A is reached upon cooling to 7

280 e enantiomer, leading to a conversion of the kinetically trapped state to the thermodynamically stabl

281 Here we show that the TAp63alpha dimer is a kinetically trapped state.

282 phase being out of equilibrium, in a surface kinetically trapped state.

283 We show that the DCoH1 homotetramer is kinetically trapped, meaning once it forms it will not d

284 isingly, although the MAX1 fibril network is kinetically trapped, solid-state NMR data show that fibr

285 ithin the peak with larger cross-section are kinetically trapped, while the more compact peak contain

286 ructures that are in equilibrium or that are kinetically trapped.

287 high-energy surfaces for catalysis that are kinetically trapped.

288 CfaA kinetically traps CfaB to form a metastable complex that

289 oid formation, whereas chondroitin sulfate A kinetically traps partially unfolded intermediates, and

290 sting that the functions of the isoforms are kinetically tuned to their individual physiological role

291 However, the protein folds in a kinetically two-state manner and is moderately stable at

292 The strains, which seem kinetically under fragmentation control, are associated

293 wer excited state where electron transfer is kinetically unfavorable.

294 ergy and selectively producing a desired but kinetically unfavourable product for the important carbo

295 ata suggest that amyloidogenic LC dimers are kinetically unstable (unfold faster) and are thus suscep

296 at MoS2 nanosheets are thermodynamically and kinetically unstable to O2-oxidation under ambient condi

297 enol ethers and ketene acetals) were studied kinetically using photometric monitoring at 20 degrees C

298 hat direct, anhydrous Cs(+)-K(+) exchange is kinetically viable and leads to the formation of phase-s

299 der thermodynamic control and can be trapped kinetically when desired are key to creating complex sys

300 uptake, as followed by pH drop, is the same kinetically, whether the boron is there or not; and (2)