ライフサイエンスコーパス: kinetoplastid

1 nal control (apicomplexa) or in its absence (kinetoplastids).

2 at creates functional mitochondrial mRNAs in Kinetoplastids.

3 a novel N-terminal sequence motif unique to kinetoplastids.

4 Three proteins have no similarities beyond kinetoplastids.

5 gulation of mitochondrial gene expression in kinetoplastids.

6 ning of a pharma compound collection against kinetoplastids.

7 mitochondria, a situation thus far unique to kinetoplastids.

8 e, whereas the enzyme is active in all other kinetoplastids.

9 However, in kinetoplastids, a group of organisms that include medica

10 trifluralin, and GB-II-5 on apicomplexan and kinetoplastid alpha-tubulin is proposed.

11 n RNA editing in the single mitochondrion of kinetoplastids, an ancient lineage of eukaryotes, is a u

12 Bodo saltans is a free-living kinetoplastid and among the closest relatives of the try

13 lore J function in RNAP II termination among kinetoplastids and avoid indirect effects associated wit

14 However, in the kinetoplastids and euglenoids, the cytochrome c(1) prote

15 egulating Pol II transcription initiation in kinetoplastids and provides the first biological role of

16 Editing was first discovered in kinetoplastids, and recent work has resulted in the char

17 Kinetoplastids are a group of flagellated protozoans tha

18 ggest that kinetochores in organisms such as kinetoplastids are built from a divergent, but not ances

19 The genomes of kinetoplastids are organized into polycistronic gene clu

20 helped facilitating successful adaptation of kinetoplastids, at multiple occasions during evolution,

21 We propose that the kinetoplastid AUR1 functional orthologue encodes an enzy

22 July 2005 marked a milestone in kinetoplastid biology research.

23 a flagellum but retains hallmark features of kinetoplastid biology, including polycistronic transcrip

24 We propose that kinetoplastids build kinetochores using a distinct set o

25 The majority is conserved among kinetoplastids, but none of them has detectable homology

26 domain but is specifically related to other kinetoplastid calpain-related proteins by a highly conse

27 lated a functional orthologue of AUR1 in the kinetoplastids, causative agents of a range of important

28 able information about sterol composition of kinetoplastid cells suggest that the substrate preferenc

29 Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were

30 ctedly possessed notable utility against the kinetoplastid disease visceral leishmaniasis (VL).

31 screening of representative examples against kinetoplastid diseases unexpectedly led to the identific

32 Kinetoplastids encode a single nuclear tryptophanyl tRNA

33 Subsequently, it has become clear that the kinetoplastid endosomal system has an active and vital r

34 In kinetoplastids, every nuclear-derived mRNA contains an i

35 ed base at Pol II PTUs within members of the kinetoplastid family.

36 successful transfection of, the free-living kinetoplastid flagellate Parabodo caudatus with three pl

37 Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the most basal

38 Kinetoplastid flagellates attach a 39-nucleotide spliced

39 Parasitic kinetoplastid flagellates represent a rare example of or

40 In kinetoplastid flagellates trans-splicing of spliced lead

41 ntial biological function of J in regulating kinetoplastid gene expression is discussed.

42 clade that includes the previously reported kinetoplastid genes, all of which are homologs of TbTOP2

43 tid genomes, but it will also identify those kinetoplastid genome features lost during the evolution

44 chore components have been identified in any kinetoplastid genome, thus challenging this assumption o

45 To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have un

46 dicate that African trypanosomes and related kinetoplastid human pathogens are unusual in having inde

47 romising therapeutic target for treatment of kinetoplastid infections, and underscore the possibility

48 RNA editing in the mitochondria of kinetoplastids involves the addition and deletion of uri

49 RNA editing in kinetoplastids is the post-transcriptional insertion and

50 toplast DNA (kDNA), the mitochondrial DNA in kinetoplastids, is a network containing several thousand

51 previously unidentified enzymes, such as the kinetoplastid J-base generating glycosyltransferase (and

52 e array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well

53 The family member in kinetoplastids, KKT-interacting protein 1 (KKIP1), assoc

54 cture reveals the five cleavage sites of the kinetoplastid large ribosomal subunit (LSU) rRNA chain,

55 NA gene locus has now been isolated from the kinetoplastids Leishmania tarentolae and Trypanosoma cru

56 g, this result contrasts the findings in the kinetoplastid Leptomonas, where mutations that restored

57 RNA binding and specificity are revealed for kinetoplastid ligases and the broader nucleotidyltransfe

58 onal dynamics and catalytic mechanism of the kinetoplastid ligation reaction.

59 ng probably originated in an ancestor of the kinetoplastid lineage and appears to have evolved in som

60 for tRNA processing in the deeply divergent kinetoplastid lineage and eukaryotes in general.

61 Uridine insertion/deletion RNA editing in kinetoplastid mitochondria corrects encoded frameshifts

62 RNA editing in kinetoplastid mitochondria inserts and deletes uridylate

63 Regulation of gene expression in kinetoplastid mitochondria is largely post-transcription

64 RNA editing in kinetoplastid mitochondria occurs by a series of enzymat

65 nsertion/ deletion RNA editing, as occurs in kinetoplastid mitochondria, to be functional, and no sho

66 odel for U insertion/deletion RNA editing in kinetoplastid mitochondria.

67 In kinetoplastid mitochondrial mRNA editing, post-transcrip

68 ting inserts and deletes uridylates (U's) in kinetoplastid mitochondrial pre-mRNAs by a series of enz

69 Kinetoplastid mitochondrial RNA editing, the insertion a

70 ion compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leis

71 onto each protein-coding transcript, mature kinetoplastid mRNA acquire a hypermethylated 5'-cap stru

72 The 5' end of kinetoplastid mRNA possesses a hypermethylated cap 4 str

73 Every kinetoplastid mRNA receives a common, conserved leader s

74 g sites in ND7 mRNA, the other characterized kinetoplastid mRNA supporting guide RNA-independent U-in

75 Kinetoplastid mRNAs possess a unique hypermethylated cap

76 t that the earliest acting components of the kinetoplastid nuclear DNA replication machinery - the fa

77 a highly diverse group of diseases caused by kinetoplastid of the genus Leishmania.

78 nt discovery in a lineage of protozoa called kinetoplastids of unconventional kinetochores with no ap

79 Kinetoplastid organisms, however, possess two highly div

80 mino acid sequences are conserved only among kinetoplastid organisms.

81 xt, including syntenic alignments with other kinetoplastid organisms.

82 m yielded the publication of three prominent kinetoplastid parasite genome sequences: Trypanosoma bru

83 n vitro than the parent compound against the kinetoplastid parasite Leishmania donovani.

84 selectively targeted to the flagellum of the kinetoplastid parasite Leishmania mexicana, but the mech

85 e we compared Erv homologues from yeast, the kinetoplastid parasite Leishmania tarentolae, and the no

86 Trypanosoma brucei is a kinetoplastid parasite of medical and veterinary importa

87 hosphoarginine/arginine kinase system of the kinetoplastid parasite Trypanosoma brucei, consisting of

88 Individual eukaryotic microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a define

89 terisation of the orthologue of SSNA1 in the kinetoplastid parasite, Trypanosoma brucei.

90 wn about topoisomerase genes and proteins of kinetoplastid parasites and the roles of these enzymes a

91 mportance for Trypanosoma brucei and related kinetoplastid parasites because these protozoa are not a

92 Kinetoplastid parasites cause lethal diseases in humans

93 The endocytic system of kinetoplastid parasites is a highly polarized membrane n

94 African trypanosomes and related kinetoplastid parasites selectively traffic specific mem

95 e only Tim component so far characterized in kinetoplastid parasites such as Trypanosoma brucei is Ti

96 Leishmania are kinetoplastid parasites that cause the sandfly-transmitt

97 he diseases are caused by infection with the kinetoplastid parasites Trypanosoma cruzi, Leishmania sp

98 biologic functions in Leishmania and related kinetoplastid parasites underscores the potential signif

99 etion RNA editing is an essential process in kinetoplastid parasites whereby mitochondrial mRNAs are

100 roviding access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of com

101 The editing complex, which is present in all kinetoplastid parasites, may thus be a chemotherapeutic

102 nsider the functional role of lipid rafts in kinetoplastid parasites, which are particularly rich in

103 coding for calpain-related proteins in three kinetoplastid parasites.

104 potent, selective antimitotic agent against kinetoplastid parasites.

105 ion of thymine residues within the genome of kinetoplastid parasites.

106 on molecular phylogeny, we suggest that the kinetoplastids pathways evolved via gene duplication and

107 reports the enzymatic properties of various kinetoplastid PDECs and the crystal structures of the un

108 ome annotation suggested that early-diverged kinetoplastids possess a reduced set of basal transcript

109 ere we describe a selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented in

110 GNF6702 inhibits the kinetoplastid proteasome through a non-competitive mecha

111 -terminal extensions are a common feature of kinetoplastid protein kinases.

112 The TbPTP1 structure, the first of a kinetoplastid protein-tyrosine phosphatase (PTP), emphas

113 All mitochondrial tRNAs in kinetoplastid protists are encoded in the nucleus and im

114 prominent role in RNA processing pathways of kinetoplastid protists typified by the causative agent o

115 f uridine insertion/deletion mRNA editing in kinetoplastid protists typified by Trypanosoma brucei.

116 In kinetoplastid protists, maturation of mitochondrial pre-

117 NA processing that occurs in mitochondria of kinetoplastid protists.

118 In common with the fungi, the kinetoplastid protozoa (and higher plants) synthesize IP

119 Sets of aligned nuclear rRNA sequences from kinetoplastid protozoa are also provided, which were use

120 The kinetoplastid Protozoa are responsible for devastating d

121 The screen expolits the observation that in kinetoplastid protozoa differentially expressed genes ar

122 Several mitochondrial mRNAs of the kinetoplastid protozoa do not encode a functional open r

123 quence of several mitochondrial mRNAs of the kinetoplastid protozoa is created only after the additio

124 quence of several mitochondrial mRNAs of the kinetoplastid protozoa is created through the insertion

125 , the genomes of trypanosomatids, a group of kinetoplastid protozoa of significant medical importance

126 Kinetoplastid protozoa such as trypanosomes and Leishman

127 ype of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing foun

128 , and many unicellular eukaryotes, including kinetoplastid protozoa, are thought to synthesize exclus

129 ituation in the mitochondrion of the related kinetoplastid protozoa, in which TGA codes for tryptopha

130 In the mitochondria of kinetoplastid protozoa, including Trypanosoma brucei, RN

131 is a complex process in the mitochondria of kinetoplastid protozoa, including Trypanosoma brucei, th

132 shmania genus and does not recognize related kinetoplastid protozoa, such as Trypanosoma cruzi, Trypa

133 ous organisms but it has not been studied in kinetoplastid protozoa.

134 riophage Rnl2 and the RNA-editing ligases of kinetoplastid protozoa.

135 odification occurring in the mitochondria of kinetoplastid protozoa.

136 n/deletion editing of mitochondrial mRNAs in kinetoplastid protozoa.

137 n has evolved within the mitochondria of the kinetoplastid protozoa.

138 d serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi.

139 NA) of Trypanosoma brucei brucei and related kinetoplastid protozoan parasites has led to many report

140 the 80S ribosome from Trypanosoma cruzi, the kinetoplastid protozoan pathogen that causes Chagas dise

141 iced leader and U1 small nuclear RNAs in the kinetoplastid protozoan Trypanosoma brucei.

142 we document t-loops in Trypanosoma brucei, a kinetoplastid protozoan with abundant telomeres due to t

143 Trypanosomatids, a group of kinetoplastid protozoans, possess a distinctive feature

144 s been used as a marker for the diversity of kinetoplastid protozoans.

145 Kinetoplastid RNA (k-RNA) editing is a complex process i

146 Kinetoplastid RNA (kRNA) editing is a process that creat

147 tic understanding and molecular inventory of kinetoplastid RNA editing and the editosome machinery.

148 RNAs, possible functions of RBP16 may be in kinetoplastid RNA editing and/or translation.

149 Kinetoplastid RNA editing consists of the addition or de

150 tion sites and is accordingly renamed KREN2 (kinetoplastid RNA editing endonuclease 2).

151 Our results suggest a model for kinetoplastid RNA editing in which chimeric molecules ar

152 Kinetoplastid RNA editing involves an exclusive class of

153 Kinetoplastid RNA editing is a posttranscriptional inser

154 T4 RNA ligase 2 (Rnl2) and kinetoplastid RNA editing ligases exemplify a family of

155 Here we investigate the similarities in the kinetoplastid RNA editing process between human- and liz

156 Kinetoplastid RNA editing protein B3 (KREPB3, formerly T

157 form a heteromeric complex that functions in kinetoplastid RNA editing.

158 Thus, p45 is the first kinetoplastid RNA-editing-associated protein (REAP-1) th

159 Kinetoplastid SepSecS enzymes are phylogenetically close

160 tract, which is common to the 3' end of all kinetoplastid SL RNA genes, and that more than six T's a

161 extracts from insect form cells of all three kinetoplastid species by using a modification of the one

162 tochondrial genes and edited mRNAs from five kinetoplastid species.

163 in extracts of three evolutionarily diverse kinetoplastid species: Trypanosoma brucei, Leishmania ma

164 any new eukaryotic parasite (apicomplexan or kinetoplastid) species or strains.

165 tial step towards finding effective and safe kinetoplastid-specific drugs.

166 Absence of both kinetoplastid-specific enzymes in TbMTr2-/-/TbMTr3-/- li

167 On the opposite side, a kinetoplastid-specific kinesin facilitates attachment of

168 pATOM36 is a kinetoplastid-specific OM protein that has previously be

169 t as a targeting signal for the glycosome, a kinetoplastid-specific organelle.

170 conserved core proteins of H/ACA snoRNPs, a kinetoplastid-specific protein designated methyltransfer

171 contain evolutionarily conserved as well as kinetoplastid-specific proteins, and component assembly

172 ng of an Aurora-like kinase, TbAUK1, and two kinetoplastid-specific proteins, TbCPC1 and TbCPC2.

173 rstanding the functional importance of these kinetoplastid-specific ribosomal features in protein-tra

174 % of these being potentially Leishmania- (or kinetoplastid-) specific.

175 vised six-transmembrane domain model for the kinetoplastid sphingolipid synthases consistent with the

176 DNA elements have been identified in several kinetoplastids such as Leishmania and Trypanosoma cruzi,

177 om cryptogene encoded RNAs and is unique for kinetoplastids, such as Trypanosoma brucei.

178 is mechanistically distinct from editing in kinetoplastid systems.

179 n contrast to drug-induced episomes in other kinetoplastids, the T. brucei extrachromosomal NR-elemen

180 enome is 9.5 Mbp in size, the smallest of a kinetoplastid thus far discovered.

181 -specific phospholipase C (GPI-PLC) from the kinetoplastid Trypanosoma brucei.

182 The kinetoplastid Trypanosoma cruzi and the eukaryote crown

183 otency and selectivity of this agent against kinetoplastid tubulin, GB-II-5 emerges as an exciting ne

184 Transcripts from many mitochondrial genes in kinetoplastids undergo RNA editing, a posttranscriptiona

185 Such differences are extreme in kinetoplastids, unicellular eukaryotic parasites often i

186 understanding of nuclear DNA replication in kinetoplastids was limited until a clutch of studies eme

187 in RNA-splicing and in RNAi systems (e.g. in kinetoplastids) which combine a distinct family of RNA-a

188 ochondrial genomes of E. gracilis and of the kinetoplastids, which is consistent with the phylogeneti

189 homology predictions to identify proteins in kinetoplastids with similarity to canonical outer kineto