ライフサイエンスコーパス: kink

1 ion mode has been indicated by a dispersion "kink".

2 were the CE turn, the EF loop, and the H-H' kink.

3 sequence of the energy of the main prominent kink.

4 onsistent with the introduction of a dynamic kink.

5 CuO4 as the exclusive origin of the measured kink.

6 of two turns of helix separated by a proline kink.

7 n has an extended shape with a small central kink.

8 ility of DNA through the introduction of DNA kinks.

9 re of DNA that prompts the appearance of the kinks.

10 pulsive by optically introducing dislocation kinks.

11 es three beta-strands connected by two short kinks.

12 tent account of our data set on the multiple kinks.

13 Here, we show a new landscape of dispersion kinks.

14 ine substitutions and evolutionary origin of kinks.

15 ched fibers, resulting in formation of fiber kinks.

16 below the headgroups, is tilted, and may be kinked.

17 Protein-bound duplex DNA is often bent or kinked.

18 olecular contours that lack obvious signs of kinking.

19 strong enough to prevent the flux rope from kinking.

20 geneous curving (~ 10 layers) and finally to kinking (20 or more layers), depending on the competitio

21 n with sac growth 5 (4%), and limb occlusion/kinking 24 (18%).

22 ere, we report the characterization of Knk1 (kink), a previously unidentified member of the superfami

23 can also be optically manipulated to induce kinks, allowing one to lock them into the desired config

24 tional main kink and a rise of another sharp kink, along with substantial energy shifts of both.

25 ld-type Cx43 revealed that it folded in to a kinked alpha-helical structure.

26 unfavourable non-ideal features--for example kinked alpha-helices, bulged beta-strands, strained loop

27 ins, a beta-barrel domain and a long, mildly kinked alpha-helix tail.

28 esults in a decline of the conventional main kink and a rise of another sharp kink, along with substa

29 The structural kink and local rigidity imposed by Pro-64 may enhance ac

30 pathway of globular collapse proceeds by a "kink and slide" mechanism, whereby a bend near the end o

31 f CO2 at 20 Torr and above, producing active kink and step sites.

32 The kink and the agonist do not interact directly.

33 the same 'loaded spring' conformation with a kink and twist between the D-stem and anticodon stem.

34 tacts but introduces torsional stresses that kink and undertwist the promoter, stabilizing an A-form

35 the membrane surface and alternates between kinked and straight-helix conformations.

36 periments, reveals that the SRP RNA adopts a kinked and untwisted conformation to allow repositioning

37 TAT-CBD3 caused a transient episode of tail kinking and body contortion.

38 wing the general connection between cumulene kinking and CC bond-breaking reactions that split off CO

39 formation mode, alongside mechanisms such as kinking and shear banding.

40 binding and dissociation, accompanied by DNA kinking and straightening, respectively.

41 fibers and revealed a torsional stiffness of kinks and cross-links of ~100-200 pN.nm/rad.

42 he heterotrimer, the homotrimer easily forms kinks and freely rotates with angles much larger than he

43 of static curvature in S[PSI(+)] fibers and kinks and self-cross-linking in W[PSI(+)] fibers.

44 It is initiated at kinks and steps edges, but the reconstruction also takes

45 by the Mid and PAZ domains and makes several kinks and turns along the binding groove.

46 lear preference for trans-like over cis-like kinks, and (iv) the extreme sensitivity of kinking with

47 trans crystal conformations between adjacent kinks, and the nanoFET was localized through modulation

48 y considered surface defects, such as steps, kinks, and vacancies, but are now just beginning to be u

49 equences, however, requires a template with "kink-and-slide" steps like those found in high-resolutio

50 ar to that of wild type but with a shallower kink angle of approximately 150 degrees .

51 less, in DOPC, we could estimate an apparent kink angle of approximately 19 degrees .

52 tely 10 degrees in the distribution of helix-kink angle, but the apo form exhibited 2 peaks, approxim

53 mations of the apo form with small and large kink angles had narrow and wide pores, respectively, aro

54 ansition is triggered by the rotation of the kink angles of transmembrane helices 2 and 7 and is medi

55 titute the first experimental observation of kink-antikink solitary wave propagation in nonlinear fib

56 on; sugar repuckering, major-groove directed kinking ( approximately 9 degrees ); and local melting o

57 emained unclear whether HMGB binding and DNA kinking are simultaneous and whether the induced kink is

58 In particular, the 50 degrees kinks are constraints imposed by the protein rather than

59 In membrane proteins, proline-mediated helix kinks are indispensable for the tight packing of transme

60 The TMD helix was found to kink around Gly-34, where water molecules penetrated dee

61 ur results clarify the notion of dislocation kinks as meaningful only for orientations within the pla

62 efined NMR and MD structures reveal a slight kink at G13 that delineates two helical segments charact

63 trinsic tertiary interactions, and molecular kink at the active site.

64 This is accompanied by an increase in kink at the central step from 22 degrees to 51 degrees ,

65 ally characterized by a sharp 70 degrees DNA kink at the position of the lesion.

66 mobility attributed to a pronounced flexible kink at the site of the lesion.

67 erial homolog, LeuT, presumably because of a kink at TM12 preventing favorable monomer packing.

68 energy by undergoing sequential, cooperative kinking at two sites that are located about 180 degrees

69 experimental observations where the peptide kinks at Phe(697) to facilitate Arg(694) snorkeling.

70 Remarkably, the kink, at the end of a G(X)4G motif highly conserved amon

71 -shaped hexamers are staggered, leading to a kinked axial channel.

72 of the propagation direction, mimicking the kink behaviour of the Crab jet.

73 can reorient, via cogwheeling (rotation) and kinking (bending), to effect changes in PHK activities t

74 A conserved proline in M1 causes a kink between alpha and pi helical segments.

75 3B requires the release of a proline-induced kink between the NC and subsequent coiled-coil 1 segment

76 Detailed experimental evidence of kink blocking validates classical theory and demonstrate

77 hree distinct modes of action: step pinning, kink blocking, and step bunch induction.

78 on adjacent layers, the latter resulting in kink boundaries.

79 A kinked bridge-helix sterically blocks the RNAP active si

80 Monomeric Abeta preserved these peaks/kinks, but oligomeric Abeta suppressed them and created

81 The RNA kinks by an association of the two minor grooves, stabil

82 Notably, the latter kink can be ascribed only to an oxygen-breathing phonon.

83 ta, we find that the experimentally observed kinks cannot be explained by a simple crossover between

84 e have sought to measure the extent of helix kinking caused by a single proline within the isolated T

85 peptide structural motif is a prominent "GG kink," centered at two glycines dividing the TM helix.

86 d amino-terminal domain interactions, form a kinked central channel.

87 rsus protein concentration can show signs of kinks: clear changes in scaling exponent, indicating cha

88 cal defect characterized by the formation of kinks close to cell tips.

89 The kinks coincide with a relatively flexible region of the

90 ing with kinked nanowire structures, but the kink configuration and device design places limits on th

91 igher percent helical content and the swivel/kink conformation is more rigid for nonpolarized systems

92 sented new geometric parameters defining the kink conformation.

93 The uniquely kinked conformation of the CD3gamma G-strand is crucial

94 cts a fraction of RNA that is already in the kinked conformation, thereby drawing the equilibrium int

95 l for channel activation, in which the small-kink conformations dominate before proton uptake by His-

96 exterior, and proton uptake makes the large-kink conformations more favorable, thereby priming His-3

97 -dynamics simulations) and to adopt multiple kinked conformations (by solid-state NMR).

98 II, we found that biasing simulations toward kinked conformations enables generating low-root mean sq

99 Remarkably, the propensity to kink correlated with the thermodynamic destabilization o

100 Loop binding in which the phosphate backbone kink created by the loop E motif causes the Specifier Se

101 alth of non-canonical DNA structures such as kinks, denaturation bubbles and wrinkled conformations t

102 th the increased flexibility required at the kinks, determines the sequence selectivity of DNA wrappi

103 significant NER response, while the flexible kink displayed in the sequence-isomeric 5'-...CGG*C...du

104 Suzuki polymerization of kinked disubstituted 1,4-dimethoxycyclohexadienylene mon

105 d by cytosines (5'CalphaAC-3') resulted in a kinked DNA duplex with an enlarged minor groove.

106 This leads to a sharply kinked DNA molecule that may fray the DNA four base pair

107 It is known, that XPA binds kinked DNA structures and that it interacts also with DN

108 Kink-driven motility, previously encountered in prokaryo

109 Although the 1,2-GG lesion stabilizes the kink due to the covalent fixation of the crosslinked dG

110 nt length of about 70 bp when sharp bends or kinks emerge in essentially every molecule.

111 It changes from a double-kink excitation below the matching field to pinning-pote

112 es mostly helical conformations but adopts a kinked, extended structure when bound by antibody 2F5.

113 The protein trimer forms kinked fibers comprised of an amino-terminal tail-attach

114 (amino acids [aa] 179 to 181) included in a "kink" followed by an extra beta strand.

115 hich in this construction appears limited by kink formation in the DNA molecular spring, in accord wi

116 L7Ae family can induce the formation of the kinked geometry, raising the question of whether this oc

117 We find that all bound RNA is in the kinked geometry, with no evidence for transitions to an

118 , we propose a local seeding model where the kinked GGA motifs in the stem region of TGGAA repeat DNA

119 eoretical analysis shows that sharp bends or kinks have to facilitate strong bending of the double he

120 A kinked helical beam and anchor domain link the Piezo rep

121 nsists of two elongated antiparallel proline-kinked helices (five AB tandem repeats).

122 holds a string of water molecules centred at kinked helices in two inverted-repeat triple-helix bundl

123 f the complete 2F5 epitope within continuous kinked helices.

124 thin the neck, moves by straightening of the kinked helix h28 at the point of contact with the mRNA.

125 We therefore predict that the kinked helix is the most fusogenic of these three confor

126 largely via hydrophobic interactions and the kinked helix of SCP bridges over neighboring MCPs to for

127 However, the kinked helix promotes lipid tail protrusion in our simul

128 more, a G2V variant peptide of Cx43 showed a kinked helix that now included V2 interactions with W4,

129 t SCP forms a crown on each hexon and uses a kinked helix to cross-link neighboring MCP subunits.

130 ion peptide structure in membranes include a kinked helix, a straight helix, and a helical hairpin.

131 on patterns in the magnitude or direction of kinking, (ii) the nonexistence of O = C horizontal lineC

132 However, a kink in H16 that makes specific contacts with the S4 N-t

133 conformation is accompanied by a 60 degrees kink in helix 6 and a large outward movement of the intr

134 water molecules, which are responsible for a kink in helix P in the apo structure.

135 lative to the membrane-water interface and a kink in its backbone that enables bending of its C-termi

136 of amino acids that are located at a proline kink in M1 that separates pi and alpha helices, in both

137 at much of the VSD, including the pronounced kink in S3 and the S3-S4 paddle, is relatively rigid on

138 In contrast, the kink in S3 is mobile on the microsecond-to-millisecond t

139 Gt CsoR reveals that Cu(I) binding induces a kink in the alpha2-helix between two conserved copper-li

140 ility was observed also in the vicinity of a kink in the beta-subunit helical region near residue bet

141 proline between V319C and E321 introduces a kink in the BK S6 inner helix sharper than that observed

142 oline, a known beta-sheet breaker, creates a kink in the center of the pore and prevents conductance

143 ion spectroscopy experiments have revealed a kink in the dispersion relations (energy versus wavevect

144 mmunoglobulin-like domains to induce a sharp kink in the DNA, exposing the damaged nucleobase to acti

145 e expansion, we show that obstacles create a kink in the front that persists over large distances and

146 The resulting kink in the inner transmembrane domain swings the aromat

147 n the transmembrane domain result in a sharp kink in the middle of transmembrane helix 6, which pivot

148 shape with flexibility and a characteristic kink in the middle.

149 romatic substitutions provide evidence for a kink in the peptide backbone.

150 mplate base is accommodated by a distinctive kink in the polymerase O helix, resulting in a partially

151 work must be done on the pore to reduce the kink in the pore-lining (S6) alpha-helices, thereby form

152 chored HpHbR, and a approximately 50 degrees kink in the receptor, allows two receptors to simultaneo

153 the dsDNA, which was best accounted for by a kink in the region of highest curvature.

154 plex other properties such as rigidity and a kink in the rod-like structure.

155 ular modeling indicates that L529I induces a kink in the S4 voltage-sensor helix, altering a salt-bri

156 t of mutating the PVPV motif that causes the kink in the S6 helix.

157 ta3-integrin cytoplasmic tail and inducing a kink in the transmembrane domain of beta3-integrin.

158 lly conserved AsnI:18 (1.50) stabilizing the kink in trans-membrane VII.

159 there are multiple distinctions, including a kink in transmembrane helix 12 halfway across the membra

160 the nucleosome, nucleosome formation causes kinking in a secondary repeat tract in the htt gene, com

161 one is sufficient to induce the formation of kinks in circles containing only 65 bp, but we did not o

162 f biologically relevant underwinding-induced kinks in DNA on the overall shape of DNA minicircles.

163 lambda-DNA in a U-turn by creating two sharp kinks in DNA.

164 ility of DNA by producing transient bends or kinks in DNA.

165 quent occurrence of Ser or Thr based helical kinks in membrane proteins suggests that a similar mecha

166 on to understand the introduction of proline kinks in membrane proteins.

167 hat is based on introducing variable dynamic kinks in terminal helices.

168 Kinks in the development of the superfluid fraction (at

169 Without Abeta, peaks or kinks in the DHE anisotropy versus X(sterol) plot were d

170 thering of the intima, resulting in multiple kinks in the luminal contour that resolved after the adm

171 Finally, we show that bends and kinks in the notochord can lead to aberrant apposition o

172 e observed to change character from pairs of kinks in the ordered phase to spin-flips in the paramagn

173 in a DPC surfactant micelle possesses a "GG kink," in the TM domain near the dynamic hinge located a

174 n, which includes two helices connected by a kink, interacts with the adjacent minor groove of DNA in

175 ing structural motif that introduces a tight kink into duplex RNA.

176 conformations not seen previously, including kinking into the DNA major groove.

177 mmonly-occurring motifs that introduce sharp kinks into duplex RNA, thereby facilitating tertiary con

178 However, kinks invariably affect numerous interhelical interactio

179 The flexibility of the GG kink is important in the processing of C99 by gamma-secr

180 Such a kink is not observed in C99(15-55) in a POPC lipid bilay

181 ing are simultaneous and whether the induced kink is rigid (static) or flexible.

182 In related receptors, the kink is straighter and more stable in O vs. C structures

183 The kink is under greater tension in the resting versus acti

184 ansistors, can be precisely localized at the kinked junctions in the nanowires.

185 cture dissipates the impact energy via layer kinking, layer compression, extreme chain conformational

186 Introducing methyl groups or using kinked ligands to create smaller pores can enhance the i

187 twinned copper are inherently defective with kink-like steps and curvature, and that these imperfecti

188 These local kinks may explain the larger lateral distance between co

189 l data and theoretical analysis suggest that kinks may represent openings of isolated base pairs, whi

190 flexion, 23 CIA and 116 EIA stenoses showed kinking (mean amplitude, 76 degrees +/- 23 and 76 degree

191 ew and the M111 orientations, both moving by kink mechanism.

192 oteins are inconsistent with either a static kink model, or a purely flexible hinge model for DNA dis

193 stacking faults and using a vacancy-mediated kink motion, and also to understand the nature of the sw

194 None of the AChR kink mutations had a measureable effect on agonist affin

195 The DnFimA structure reveals an extended kinked N-terminal alpha-helix, an unusual centrally loca

196 inaceous nanopores of comparable dimensions, kinked nanopores exhibit up to fivefold reduction in tra

197 cale connections are made by the arms of the kinked nanostructure, and remote multilayer interconnect

198 rated FET-based intracellular recording with kinked nanowire structures, but the kink configuration a

199 to-nanoscale metal pillars, transistor-based kinked nanowires and nanotube devices.

200 A distortion or kink near residues 18-22 introduces pliancy in the angle

201 growth site is found to be rate-limiting for kink nucleation, with this process having a lower activa

202 e resolution of our experiments, this static kink occurs at the instant the protein binds to the DNA,

203 beta(3)(Pro 711) introduced a TMD kink of 30 +/- 1 degrees precisely at the border of the

204 f helix M2 (as in locally closed form) and a kink of helix M1, both helices no longer interacting acr

205 l changes of the DNA, including a 90 degrees kink of the DNA duplex and organization of the single-st

206 the recognition step for IHF is spontaneous kinking of cognate DNA to adopt a partially prebent conf

207 ce of HF development leads to shortening and kinking of the mouse tail.

208 nd increased in diameter in association with kinking of the optic nerve sheath.

209 the structure but that there are two sharper kinks of 50 degrees at +/-2 helical turns from the centr

210 revealed a NB-shaped Au structure with many kinks on its surface, which allow local electric field e

211 developed at the anastomosis, within a bend/kink or distally.

212 a change in the magnetic topology, as in the kink or torus instability; and coronal jets from a resis

213 ition (for example, when a base pair step is kinked or a region of the minor groove is narrow).

214 and growth of nanowires, and use it to grow kinked or zigzag nanowires in which the straight section

215 icable to any structural type of disruption, kinks or opening of single basepairs.

216 Although n-alkanes have no branches, the "kinks" (or "protobranches") in their chains (defined as

217 cally (bubbles), sustains large-angle bends (kinks), or can locally transform into an alternative (S-

218 ns of unfolding, chain separation, localized kinks, or joints.

219 rins, domains EC2' and EC3' are joined in a "kinked" orientation by a previously uncharacterized Ca(2

220 i) Thr175, Tyr177, Leu179, and Asp180 at the kink overlapping the integrin-binding site; (ii) Arg153

221 otion proceeds via the thermal nucleation of kink pairs.

222 t to a single Ca(2+) entry site close to the kinked part of the first transmembrane helix, in a regio

223 n, diameter, growth direction, branching and kinking, periodic twinning, and crystal structure.

224 he temporal transfer of oxygen ions near the kink positions of the two different-diameter portions of

225 eviously shown that sequence nonspecific DNA kinking proteins, such as Escherichia coli heat unstable

226 d via a hydrophobic interface located in the kink regions of the two solenoids that is reinforced by

227 This kink, resulting from steric hindrance between the 5'-fla

228 utotransporter proteins, possesses a central kink revealing a distinctly curved structure.

229 n growths, including the formation of nodes, kinks, scale-like interfaces, and curved backbones.

230 tility of T. brucei is by the propagation of kinks, separating left-handed and right-handed helical w

231 t enhance DNA flexibility at the site of the kinks show 3- to 4-fold increase in DNA bending rates th

232 Here we report the formation of 'kinked' silica nanopores, using evaporation-induced self

233 fabricating free-standing probes in which a kinked silicon nanowire with an encoded field-effect tra

234 nanoFET) device at the tip of an acute-angle kinked silicon nanowire, where nanoscale connections are

235 terrace site neighboring an occupied step or kink site, thus nucleating a 2D island on a terrace.

236 bute this high initial heat to Ca binding to kink sites (376 kJ/mol), step sites (205 kJ/mol), and lo

237 large number of palladium atoms on ledge and kink sites of hollow nanocages are advantageous to enhan

238 , while sequence modifications away from the kink sites, as well as mutations in IHF designed to dest

239 ionalized by considering additive binding to kink sites, which is consistent with crystal growth by a

240 he activity is greatly enhanced at strained (kinked) sites and regions modified by oxidation.

241 information in the form of a sharp magnetic kink soliton to be unidirectionally pumped (or 'shifted'

242 cidate the electronic origin of the curious "kinked'" spine geometries that are common in such specie

243 ly complementary strand, suggesting that the kinked state is locally melted.

244 elasticity, without the need to invoke any 'kinked' states.

245 ng studies indicate that NS1643 binds to the kinked structure induced by the mutation with a higher a

246 modeling of the SAXS data results in a long kinked structure of the ternary complex, showing an angl

247 ther this occurs by passive selection of the kinked structure, or a more active process in which the

248 in an extended form, or by folding into the kinked structure.

249 ntercalates into the duplex to stabilize the kinked structure.

250 its conformational isomers, a pi-diradical "kinked" structure, and cation and neutral radicals.

251 are Ba-O layer terminated, and two kinds of kink structures at the Ruddlesden-Popper faults with dif

252 ucture, and that Cu(751) has a heterogeneous kinked surface with (110) terraces that is closely relat

253 king of a primary structural unit based on a kinked Ta-O-Ta backbone.

254 ary anomalies including shortened body-axis, kinked tail, hydrocephaly and edema but does not affect

255 offspring with different coat colors or with kinked tails.

256 dine-purine steps deform at low cost along a kinked template whereas sequences that resist deformatio

257 ine-valine-proline motif, which introduces a kink that allows for electromechanical coupling with vol

258 uch as a climbing plant tendril, refers to a kink that connects two helices with opposite chiralities

259 consistent with formation of a single static kink that is short lived (lifetimes of a few seconds) un

260 Between nucleotides 6 and 7, there is a kink that may function in microRNA target recognition or

261 undamaged fibrils-were first created within kinks that developed at discrete, repeating locations al

262 nts in RNA that mediate tertiary contacts by kinking the helical axis.

263 lycine residue 61, which allows a 30 degrees kink to form in alpha-helix 3 in two subunits, whereas t

264 played along a single, peripheral, regularly kinked topoisomerase II/cohesin/condensin II axis.

265 NMR studies of MMP23-PD reveal a single, kinked trans-membrane alpha-helix, joined by a short lin

266 onella pneumophila Cu(+)-ATPase shows that a kinked transmembrane segment forms a "platform" exposed

267 suggest that straightening of the M1 proline kink triggers AChR desensitization.

268 sing a three-way helical junction based upon kink turn (k-turn) architecture.

269 -23 from Thelohania solenopsae is a rare RNA kink turn (k-turn) where an adenine replaces the normal

270 s including L7Ae, which is known to bind the kink-turn (K-turn), an RNA structural element that cause

271 ticodon loop and is flanked on one side by a kink-turn (K-turn), or GA, sequence motif.

272 e identify in the Mma RNase P RNA a putative kink-turn (K-turn), the structural motif recognized by L

273 for kink-turn, C-loop, sarcin-ricin, reverse kink-turn and E-loop motifs against a 23S rRNA (PDBid: 1

274 7 binds to a portion of helix 11, inducing a kink-turn in that helix that bends helix 7 toward the S1

275 rent RNA 3D motifs (such as sarcin-ricin and kink-turn internal loops or T- and GNRA hairpin loops) i

276 ry contacts and the bimodal stability of the kink-turn motif for function.

277 nsistent predictions for a new stem P0 and a kink-turn motif.

278 NAMotifScan is demonstrated by searching for kink-turn, C-loop, sarcin-ricin, reverse kink-turn and E

279 many known motifs including GNRA tetraloop, kink-turn, C-loop, sarcin-ricin, reverse kink-turn, hook

280 op, kink-turn, C-loop, sarcin-ricin, reverse kink-turn, hook-turn, E-loop and tandem-sheared motifs,

281 potential novel instances of GNRA tetraloop, kink-turn, sarcin-ricin and tandem-sheared motifs.

282 Kink turns (k-turns) are important structural motifs tha

283 Kink turns (k-turns) are widespread elements in RNA that

284 Kink turns (k-turns) are widespread structural elements

285 Kink turns are widely occurring motifs in RNA, located i

286 equence and distinct secondary structures of kink-turns (k-turn) suggest computational folding rules

287 nown 3D motifs, such as tetraloops, E-loops, kink-turns and others.

288 These results support the presence of two kink-turns, the structural motifs recognized by L7Ae, in

289 N-terminus and (B) to the lack of a helical kink upon ligand binding.

290 There, collagen denaturation within the kinks was concentrated within certain subfibrils.

291 t (f-I) curves that exhibit a suitably sized kink where the slope of the curve decreases more abruptl

292 ween these two processes can account for the kinks which we observe in our and others' experimental d

293 phipathic alpha helices separated by a rigid kink, which prevents intramolecular association and pres

294 The kink, which reduces the tilt of the C-terminal helical d

295 hape, with proline or serine residues at the kinks, which functions as a lever-arm, coupling the subs

296 t: Fz7(-/-) mice exhibit tail truncation and kinking with 100% penetrance and ventricular septal defe

297 e kinks, and (iv) the extreme sensitivity of kinking with respect to weak perturbations, such as cage

298 These growth directions can change at kinks with no observable crystallographic defect.

299 olecular bending of the Ndc80 complex at the kink within the stalk region of the Ndc80-Nuf2 dimer [4,

300 at bending strain can localize hyperflexible kinks within the DNA template, which in turn reduces the