ライフサイエンスコーパス: knock out

1 citable phenotype similar to the conditional knock-out.

2 ritic complexity is lowest in the homozygous knock-out.

3 surge were overcome by neuron-specific SOCS3 knock-out.

4 was validated by a CRISPR/Cas9 mediated ZnT8 knock-out.

5 s in which the plasminogen receptor (KT) was knocked out.

6 ions when the OG repair glycosylase Ogg1 was knocked out.

7 These pLoF mutations are estimated to knock out 1,317 genes, each in at least one participant.

8 Knocking out a homolog of fungal Zn(II)2Cys6-encoding ge

9 e-to-inosine substitution, which selectively knocks out a Watson-Crick-type (G)N2H2...O2(T) hydrogen

10 of Tyr181Cys RT (CRTIs) that can completely knock out activity of the resistant mutant and of the pa

11 Knocking out ALC would increase shatter resistance to av

12 sed genome editing offers the possibility to knock out almost any gene of interest in an affordable a

13 CRISPR/Cas9-mediated gene editing to stably knock out and recover Rab8a in macrophage cell lines, we

14 riptomic consequences of PLAG1 deficiency in knock-out and heterozygous mice compared to wild-type mi

15 e and human- disease-allele point mutants or knock-out and knockdown models, we show that disruption

16 Both knock-out and overexpression mutants of MtMATE55 showed

17 Similarly, maternal Slc6a4 knock-out and prenatal stress in rodents results in offs

18 Malat1 knock-out and wild-type mice were subjected to 1 h of mi

19 daily sperm production and sperm motility in knock-out and wild-type mice.

20 ensitive to pertussis toxin or beta-arrestin knock-out, and mimicked by Gs-DREADD stimulation, sugges

21 as been called into question or conventional knock-out animal models in which compensatory mechanisms

22 However, using knock-out animals (of MT-III and vesicular Zn(2+) transp

23 protein abundance in the colon of the Nedd4L knock-out animals was increased, indicating that Nedd4L

24 Using apolipoprotein E knock-out (apoE(-/-)) mice on a high fat (HF) diet as an

25 Compared with apolipoprotein E knock-out (ApoE(-/-)) mice, which show impaired clearing

26 Using a conditional knock-out approach to knock out Nedd4L in mice intestina

27 n either beta-cell specific insulin receptor knock-out (betaIRKO) or control mice.

28 In SIRT3 knock-out bone marrow-derived macrophages, NLRP3 activat

29 or nuclease gene editing technology, we have knocked out both EVI and MDS/EVI and have shown that EVI

30 ced in HAP1 cells in which the PKD1 gene was knocked out by clustered regularly interspaced short pal

31 Blocking or knocking out CCR5 or its ligand CCL5 significantly block

32 In addition, we generated a knocked-out cell model for ts-101 and ts-46 in HEK-293 c

33 ockdown of both ZDHHC3 and ZDHHC7 in ZDHHC20 knock-out cells decreased endogenous IFITM3 palmitoylati

34 Intracellular Ca(2+) was higher in PC1-knock-out cells than in control cells.

35 ting in 4-fold lower PPARgamma expression in knock-out cells than in wild-type cells.

36 In proximal tubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) a

37 toxymethyl ester) reduced cAMP levels in PC1-knock-out cells.

38 ses, such as axon guidance, we conditionally knocked out Celsr3 in the hippocampus 1 week after birth

39 Using germline and conditional knock-out (cKO) mouse models, we show that Tshz1 is requ

40 Here, O-glycan biosynthesis was truncated by knocking-out Core 1 beta3Gal-T Specific Molecular Chaper

41 DSCs formed significantly less bone in COX-2 knock-out (Cox-2KO) than in COX-2 wild-type (WT) mice.

42 We knocked out Ctcf postnatally in glutamatergic forebrain

43 Knocking out Ctcf in mouse embryonic neurons is lethal b

44 We created a mouse with conditional Cx26 knock-out (Cx26 cKO) in DCs and PCs that did not influen

45 We find that knocking out D2Rs eliminates the ADP in a cell-autonomou

46 lysis of a Pseudomonas aeruginosa quiC1 gene knock-out demonstrates that it is important for growth o

47 lacking the mutation, individuals with APOC3 knocked out displayed marked blunting of the usual post-

48 sclerosis; 2) apoE(-/-)/miR-155(-/-) (double knock-out (DKO)) mice show HF diet-induced obesity, adip

49 Specifically, knocking out eEF2K in mice eliminated phosphorylation of

50 llular cAMP, we utilized a phosphodiesterase knock-out Escherichia coli strain, DeltacpdA, where inte

51 orphosis in X. tropicalis On the other hand, knocking out EVI and MDS/EVI causes severe retardation i

52 AgRP-LepR knock-out female mice exhibited mild obesity and adiposi

53 months of HCD feeding, infertility onset in knock-out females was delayed by 4 weeks.

54 in Drosophila cells in culture, and DJ-1beta knock-out flies, we could detect no contribution of DJ-1

55 congenital myotubular myopathy mouse model (knock-out for the myotubularin coding gene Mtm1) that a

56 Animal models knocked out for MTM1 show severe reduction of ryanodine

57 n of nude NOD/SCID/IL2rg(-/-) (NSIN) mice by knocking out Foxn1 from NOD/SCID/IL2rg(-/-) (NSI) mice u

58 ed a system where the endogenous TCR-beta is knocked out from the recipient cells using clustered reg

59 that expression of erythropoietin in a GnTI knock-out, FUT8-overexpressing cell line results in the

60 Here, we use CRISPR base editors to knock out genes by changing single nucleotides to create

61 ceptor 1 mediated calcium release but, since knocking out genes in animal models does not necessarily

62 re, we recommend an alternative approach for knocking out genes, which combines CRISPR/Cas9 with gene

63 indromic repeats (CRISPR)/Cas9 technology to knock out GRASP55 and GRASP65, individually or in combin

64 A comparison of WT and Gsk3a;Gsk3b knock-out (Gsk3 DKO) ESCs revealed prominent GSK-3-depen

65 Behavior of Hdc knock-out (Hdc KO) mice was assessed in an open field te

66 e-editing approach to generate a human COX18 knock-out HEK293T cell line that displays isolated compl

67 Here we demonstrate that CRISPR/Case9 knocking out Hsp90alpha nullifies tumour cells' ability

68 Knocking out Hsp90beta leads to tumour cell death.

69 nges in hyperoxia-exposed animals (WT versus knock-out) identified 171 genes unique to Cyp1a1-/- and

70 We found that MMP-3 inhibition or knock-out impaired late-phase LTP in the CA3-CA1 pathway

71 striatonigral but not in the striatopallidal knock-out in response to l-DOPA treatment.Our work shows

72 evelopmental processes, because inducing OGT knock-out in the sensory neurons of adult mice results i

73 172 (glioblastoma multiforme) cell lines and knocked out in HUH7 (liver cancer) cells.

74 ceptor (D1-KO), but not mice where WAVE1 was knocked out in neurons expressing the D2 dopamine recept

75 ssential for Wnt secretion, is conditionally knocked out in the floor plate.

76 all three glucose degradation pathways were knocked out indicate that the ED pathway is physiologica

77 ycanopathy mouse model due to Fukutin (Fktn) knock-out indicated a dose-dependent toxicity.

78 When these genes were knocked out individually in GGTA1/CMAH DKO RMEC, 32 gene

79 Indeed, Sufu knock-out is lethal in mice, and recessive pathogenic va

80 We have used a knock-out/knock-in strategy in Drosophila to generate a

81 yramidal neurons in the barrel cortex of BC1 knock out (KO) mice display larger excitatory postsynapt

82 e, using RNA-binding protein HuR conditional knock-out (KO) and wild-type (WT) mice, we present evide

83 Accordingly, E4f1 knock-out (KO) keratinocytes exhibited impaired PDH acti

84 IP14 in manganese homeostasis, we used Zip14 knock-out (KO) male and female mice to conduct comparati

85 Ptchd1 knock-out (KO) male mice exhibit cognitive alterations,

86 sponses to whisker stimulation in young Fmr1 knock-out (KO) mice (postnatal days 14-16), a model of F

87 ogical function of CPEB2, we generated CPEB2 knock-out (KO) mice and found that most died within 3 d

88 (HO) and heterozygous (HET) Mybpc3-targeted knock-out (KO) mice we show that crypts (one or two) are

89 PAK4 knock-out (KO) mice were born at Mendelian ratios in bot

90 Wild-type (WT) and TRPC5 knock-out (KO) mice were fed a diet supplemented with 0.

91 aging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to t

92 ion in the heart, we took advantage of MEF2A knock-out (KO) mice, a model that displays a predominant

93 In Pml knock-out (KO) mice, ablation of Pml largely reduces IFN

94 ntrast, in hippocampal slices from calpain-1 knock-out (KO) mice, application of the mGluR agonist, D

95 APOE-targeted-replacement (APOE-TR) and APOE-knock-out (KO) mice, with neuroinflammation induced by l

96 upregulation of NMDARs, we also analyzed PrP knock-out (KO) mice.

97 ied their roles using global and conditional knock-out (KO) mice.

98 L2/3 pyramidal neurons in adult V1 of Lynx1 knock-out (KO) mice.

99 erated a novel skeletal muscle-specific GRK2 knock-out (KO) mouse (MLC-Cre:GRK2(fl/fl)) to gain a bet

100 We used conditional and conventional knock-out (KO) mouse lines, with viral expression of Cre

101 nus neurotoxin (TeNT), also in TI-VAMP/VAMP7 knock-out (KO) neurons).

102 applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then analyzed the c

103 rinking using the following models: (1) Tlr4 knock-out (KO) rats, (2) selective knockdown of Tlr4 mRN

104 Here we report that mice in which WAVE1 was knocked out (KO) in neurons expressing the D1 dopamine r

105 andom integrants for purposes including gene knock-out libraries, screening for optimal integration p

106 ession profiles of a mouse p38alpha (Mapk14) knock-out line to the original wild-type.

107 he main contributor to the MGPA as grains of knock-out lines show very low MGPA.

108 We found that PRMT1 knock-out macrophages failed to up-regulate PPARgamma ex

109 In support of this mechanism, eEF-2K knock-out MCF10A cells reconstituted with eEF-2K S500D d

110 x assays combined with pharmacology and gene knock-out methods, we discovered a previously unrecogniz

111 L-6, IL-1beta, and ccl5 in the skin of IFNAR knock out mice following subcutaneous administration.

112 In beta2-microglobulin knock out mice, the D76N beta2-microglobulin/ Nb24 pre-f

113 In Cx26 conditional knock-out mice (Cx26(Sox10-Cre)), the maturation of IHCs

114 t-specific protein-1 driven conditional Cx43 knock-out mice (Cx43fsp1KO).

115 We used male and female heterozygous Gnal knock-out mice (Gnal(+/-)) to study how GNAL haplodefici

116 s in R1a subunit expression are seen in Fmr1 knock-out mice (KO) mice, a widely used animal model of

117 cardiac fibroblasts isolated from PI3Kgamma knock-out mice (PI3KgammaKO) showed decreased insulin-st

118 Using both transgenic and knock-out mice along with in vitro assays, our data show

119 thionine biosynthesis by constructing LanCL1 knock-out mice and measuring LK concentrations in their

120 ype previously reported in alphaB-crystallin knock-out mice and suggests that the elevated chaperone

121 recordings from hippocampal neurons of KCTD knock-out mice are consistent with these findings and in

122 at the phenotypical changes in collagen XIII knock-out mice are milder than symptoms in human patient

123 s, several neurological phenotypes of R7-RGS knock-out mice are not readily explained by dysregulated

124 Furthermore, adipose-specific Dnmt3a knock-out mice are protected from diet-induced insulin r

125 nese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biolo

126 LTD was absent in CB1 knock-out mice but preserved in heterozygous littermates

127 ST were up to 2.7 times greater in alphaENaC knock-out mice compared with the respective field volume

128 s or a control vector into the CeA of orexin knock-out mice crossed with vGAT-Cre mice, resulting in

129 We showed that myeloid-specific PRMT1 knock-out mice demonstrate higher proinflammatory cytoki

130 e experiments on kisspeptin-specific ERalpha knock-out mice demonstrate that ERalpha in kisspeptin ce

131 Analyses of Tulp1 knock-out mice demonstrate that Tulp1 is essential to ke

132 Selective antagonists and neurons from knock-out mice demonstrated a BLT1-dependent sensitizati

133 ely 800-1000-fold), indicating that Slc30a10 knock-out mice develop hypothyroidism.

134 uPA-knock-out mice developed fewer and smaller TSC2-null lun

135 The Dlx1/Dlx2 double knock-out mice die at birth with abnormal cortical devel

136 Ric-8b conditional knock-out mice display impaired olfactory guided behavio

137 es CerS3 activity, whereas cytosol from ACBP knock-out mice does not.

138 Pcmt1 knock-out mice exhibit a profound neuropathology and die

139 avioral analyses show that PRMT8 conditional knock-out mice exhibit impaired hippocampal-dependent fe

140 hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a comprehensive brake in their

141 r, after weaning and compared with controls, knock-out mice failed to gain weight, were smaller, and

142 (PcTx1) and the absence of these currents in knock-out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest

143 rated inducible and skeletal muscle-specific knock-out mice for Rheb (iRhebKO) and TSC2 (iTSC2KO) and

144 both inducible and skeletal muscle-specific knock-out mice for Rheb and iTSC2KO mice.

145 Unfortunately, the available P2RX7 knock-out mice generated by pharmaceutical companies pos

146 Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after bi

147 lowing AKAP siRNA transfection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685 phosp

148 Although Cdkl5 constitutive knock-out mice have recapitulated key aspects of human s

149 r studies performed on P2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are involved in t

150 Accordingly, the neuroretina of PrP-knock-out mice is iron-deficient.

151 We found that olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf

152 Adiponectin knock-out mice receiving dextran sulfate sodium exhibite

153 Given that the receptor double knock-out mice resemble reeler mutants, we infer that Re

154 xogenous expression of human Stbd1 in double knock-out mice restored the liver lysosomal glycogen con

155 of the vertebrate P3H family, P3h3 and Sc65 knock-out mice revealed a common lysine under-hydroxylat

156 ts showed that the olfactory-specific Ric-8b knock-out mice show an impaired sense of smell, even tho

157 Furthermore, we report that aged APLP1 knock-out mice show impaired basal transmission and a re

158 holesterol atherogenic diet-challenged Sort1 knock-out mice showed less hepatic free cholesterol accu

159 of cultured neurons from wild-type and SUMO1 knock-out mice showed that anti-SUMO1 immunolabelling at

160 sma analyses of single-proprotein convertase-knock-out mice showed that loss of the convertase furin

161 yte-specific furin, PC5/6, or complete PACE4 knock-out mice suggested that the cleavage of overexpres

162 Furthermore, knock-out mice that lack PLK2 (the predominant kinase th

163 Generation of knock-out mice that lacked PEMT showed that they were pr

164 We then use conditional knock-out mice to eliminate FMRP only in the PFC alone o

165 Here, we produced Dgcr8 conditional knock-out mice using progesterone receptor (PR)-Cre (Dgc

166 Paradoxically, excitability in kisspeptin knock-out mice was similar to the maximum observed in co

167 Adiponectin knock-out mice were orally administered dextran sulfate

168 Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperar

169 Knock-out mice without functional mGluR5 exhibit severe

170 sosomal glycogen content to the level of GAA knock-out mice, as did a mutant lacking the Atg8 family

171 ogenesis were downregulated in the testes of knock-out mice, as well as Hsd17b3, which encodes a key

172 combinant TRX in wild-type mice, but not TG2 knock-out mice, led to a rapid rise in intestinal transg

173 by using anti-murine Abeta antibodies or APP knock-out mice, prevents the cGMP-dependent enhancement

174 preoptic nucleus of fever-refractive mPGES-1 knock-out mice, resulted in a temperature elevation in r

175 rrel cortex activity in young and adult Fmr1 knock-out mice, the mouse model of fragile X syndrome (F

176 In Exoc5 photoreceptor-specific knock-out mice, the photoreceptor outer segment structur

177 Taking advantage of the conditional Oxtr knock-out mice, the present study highlights the importa

178 hippocampal cultures from Arp2/3 conditional knock-out mice, we analyze the roles of the Arp2/3 compl

179 Using conditional Gdnf knock-out mice, we found that endogenous GDNF affects st

180 Here, using conditional knock-out mice, we show that hippocampal-dependent learn

181 Using connexin knock-out mice, we show that IHCs fire spontaneous actio

182 nutrient deprivation in wild-type and SIRT3 knock-out mice.

183 d spread of labels were greater in alphaENaC knock-out mice.

184 ocampal-dependent memory in male conditional knock-out mice.

185 BLT1 and TRPV1 as shown using the respective knock-out mice.

186 ontrol experiments showed no labeling of TG2 knock-out mice.

187 sh mutants, and photoreceptor-specific Exoc5 knock-out mice.

188 on of these molecules was observed in ERK1/2 knock-out mice.

189 hibition of HDAC6 reduced cyst growth in PC1-knock-out mice.

190 lammasome in wild-type mice but not in SIRT3 knock-out mice.

191 ence in survival between wild-type and PRMT1 knock-out mice.

192 notype was similarly severe in each of these knock-out mice.

193 onset of learning in both FX and conditional knock-out mice.

194 ce neutrophil apoptosis was impaired in AnxA-knock-out mice.

195 , Rag2(-/-), and Rag2(-/-)xParp1(-/-) double knock-out mice.

196 rent was lacking in DGGCs from delta-subunit knock-out mice.

197 triggered a vigorous immune response in ZnT8 knock-out mice.

198 tes to the infection susceptibility in PRMT1 knock-out mice.

199 Cdc42, we generated myeloid-restricted Cdc42 knock-out mice.

200 ct against cholesterol lipotoxicity in Sort1 knock-out mice.

201 that have previously been reported in VGLUT3 knock-out mice.

202 manifestations of EAE disappeared in miR-142 knock-out mice.

203 at the organism level, we generated Slc30a10 knock-out mice.

204 We have established the first glyoxalase 1 knock-out model (GLO1(-/-)) in mammalian Schwann cells u

205 Here, we used a mouse knock-out model in which the transduction component used

206 address this question, we generated cellular knock-out models of FA core complex components and FANCD

207 have generated a T cell-specific Coronin 1a knock-out mouse (Coro1a(fl/fl) x Cd4[Cre]).

208 c-8b in vivo, we generated a tissue specific knock-out mouse by crossing OMP-Cre transgenic mice to R

209 Adiponectin knock-out mouse colons had markedly reduced proliferatio

210 ls in the forebrains of the Dlx1/Dlx2 double knock-out mouse in vivo Identification of Gad genes as d

211 ation, we generated an inducible conditional knock-out mouse in which the L-VGCC isoform Cav1.2 was d

212 se of a conditional, hepatocyte-targeted AHR knock-out mouse model (Cre(Alb)Ahr(Fx/Fx)).

213 athology, we generated a heterozygous Pabpn1 knock-out mouse model (Pabpn1+/Delta).

214 We developed and characterized a conditional knock-out mouse model and found that GSKIP deficiency ca

215 own to ameliorate mitochondrial disease in a knock-out mouse model lacking a nuclear-encoded gene spe

216 analyzed brain structure in a maternal Ube3a knock-out mouse model of AS.

217 by studying an inducible SC-specific Gpr126 knock-out mouse model.

218 ses in vivo, we created a cell type-specific knock-out mouse model.

219 Thus, we generated a Slc25a46 knock-out mouse model.

220 e generated a cardiac-specific and inducible knock-out mouse model.

221 Fibroblasts from Optn knock-out mouse showed reduced LC3-II formation and a lo

222 rther examined the role of COX2 using a COX2-knock-out mouse where pFUS was unable to increase MSC tr

223 Using a new alphaII spectrin conditional knock-out mouse, we show that alphaII spectrin is requir

224 ng the specific Gq inhibitor, UBO-QIC, or Gq knock-out murine platelets, we demonstrate that Gq signa

225 sed in transgenic plants of a PORB-deficient knock-out mutant (porB) of Arabidopsis thaliana.

226 promotes root elongation, whereas AtbHLH112 knock-out mutant displays an opposite phenotype.

227 infected with a wild-type IAV and its PB1-F2 knock-out mutant for analyses at different times post-in

228 dying peripheral myelinated fibers in Schip1 knock-out mutant mice.

229 In a gldh knock-out mutant, complex I is not detectable, suggestin

230 T-DNA knock-out mutants of At3g57630 showed a truncated root h

231 The true knock-out mutants of MPK1 were severely dwarfed and ster

232 month-old) Gba1 mouse models, one carrying a knock-out mutation and the other a L444P knock-in mutati

233 Using a conditional knock-out approach to knock out Nedd4L in mice intestinal epithelium (Nedd4L(f

234 We found that homozygous Celf1 knock-out neonates exhibited cardiac dysfunction not obs

235 Previously, knock-out of Arhgef18 in the medaka fish has been shown

236 In support of this hypothesis, conditional knock-out of ARPP-16 in CaMKIIalpha::cre/floxed ARPP-16/

237 Conditional knock-out of ARPP-16/19 is associated with increased mot

238 Finally, conditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expres

239 er in the expression of LID, the kinase CK2: knock-out of CK2 in striatonigral and striatopallidal ne

240 We report here that knock-out of CK2 in striatonigral neurons reduces the se

241 We discovered that the knock-out of HO in P. berghei is lethal; therefore, we i

242 Accordingly, knock-out of HuR reduced CCR6 expression on Th17 cells a

243 Unlike knock-out of individual ZDHHCs, siRNA-mediated knockdown

244 Knock-out of MICAL3 leads to an increased frequency of c

245 Accordingly, genetic knock-out of mouse ShcD enhances Erk phosphorylation in

246 ten requires overexpression, knock-down, and knock-out of multiple gene targets.

247 Sensory neuron-specific knock-out of OGT results in behavioral hyposensitivity t

248 sion of PCBP2 inhibits, whereas knockdown or knock-out of PCBP2 increases, the production of reactive

249 Sox2, Oct4 (Pou5f1), Nanog], and conditional knock-out of Sox2 during fracture healing results in red

250 We therefore generated a conditional knock-out of the NADPH-P450 oxidoreductase (Por) gene co

251 As expected, the knock-out of TSC2 led to an elevation in the basal level

252 by torin 1, or CRISPR/Cas9-mediated genetic knock-out of tuberous sclerosis complex-2 (Tsc2) blocked

253 Notch1, a known ADAM10 substrate, when knocked out of DCs (Notch1(DC)(-/-) ) demonstrated a sim

254 was either genetically or pharmacologically knocked out or genetically overexpressed in cardiomyocyt

255 ice and SH-SY5Y cell models, we specifically knocked out or knocked down gene expression of mapk14, w

256 d in human and mouse cells while selectively knocking out or down critical BER proteins to identify t

257 phenotypes could be reproduced or rescued by knocking out or restoring BMAL1 exclusively in skeletal

258 singly, when K(ATP) channels are genetically knocked out, oscillations in islet activity persist, and

259 glt1-knock-out parasites exhibited a growth defect not rescue

260 o in the context of mitochondrial damage, we knocked out Parkin in a mouse model in which the mitocho

261 on mitochondrial quality control in vivo by knocking out Parkin in the PD-mito-PstI mouse (males), w

262 report results obtained with conditional PC4 knock-out (PC4(f/f) Nestin-Cre) mice where PC4 is knocke

263 ted to peroxisome membranes could rescue the knock out phenotype and interacted with Fission1 on the

264 s the changes in circadian period evident in knock-out phenotypes and individuals with PER3-related c

265 CRISPR/Cas9 gene editing was used to knock out pig conceptus IL1B2 expression and the secreti

266 MMP-3 inhibition and knock-out prevented the induction of vdccLTP, with no ef

267 butes to the proliferative phenotype of Spop knock-out prostates.

268 icantly lower in mid-aged (>10-month-old) PV-knock out (PV-KO) mice.

269 ts obtained from skin of heterozygous Ndufc2 knock-out rat model showed marked mitochondrial dysfunct

270 ted cell line model systems, and a GalNAc-T2 knock-out rat model, we show that GalNAc-T2 co-regulates

271 Spinophilin knock-out results in enhanced mGluR5 endocytosis as well

272 Pooled CRISPR-Cas9 knock out screens provide a valuable addition to the met

273 oding a genome-editing agent can efficiently knock-out selected genes in anti-cancer T-cells.

274 easibility of CRISPR-Trap by utilizing it to knock out several genes in different human cell lines.

275 A bound to live INS-1E cells, whereas a ZnT8 knock-out specifically reduced the surface binding.

276 -out (PC4(f/f) Nestin-Cre) mice where PC4 is knocked out specifically in the brain.

277 Knocking out spineless using CRISPR/Cas9 leads to the lo

278 the role of FplA, we developed an fplA gene knock-out strain, which will guide future in vivo studie

279 -fold changes in expression level in an OmpR knock-out strain.

280 bolic differences akin to those generated by knock-out strains engineered in the laboratory used to e

281 Genetic (knock-out) studies indicate that the derived diterpenoid

282 expressed in multiple cancers, and the PYCR1 knock-out suppresses tumorigenic growth, suggesting that

283 l and hippocampal tissues isolated from T1R3 knock-out (T1R3KO) mice.

284 ield stimulation, the patch-clamp method and knock-out technology, we determined the sources and cons

285 inhibitor of SM synthase or using CRISPR to knock out the Sms2 gene recapitulated the palmitate effe

286 glial fibrillary acidic protein promoter to knock out the transcription factor signal transducer and

287 mulation can be engineered in A. thaliana by knocking out the HAC1 gene and expressing PvACR3.

288 Here, we show that knocking out the Ras homolog family member A (RhoA) gene

289 Indeed, we found that knocking out these genes caused a number of chloroplast

290 We find that PTP is unchanged in PKC triple knock-out (TKO) mice in which all calcium-dependent PKC

291 /3) may confer a compensatory effect, triple knock-out (TKO) mice were also generated and tested.

292 (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, TKO and wild type (WT) mouse brains, suggesti

293 s dyskinesia in animals with striatopallidal knock-out to wild-type levels, suggesting a dependence o

294 le-positive, non-target NCI-H358-HER2 CRISPR knock out tumors in nude mice bearing dual-flank tumor x

295 atient-specific differences were mimicked by knocking out UBE3A using CRISPR/Cas9 or by knocking down

296 (-/-) pregnant mice alleviated the effect of knocking out UCP2 on pancreas development.

297 carbohydrate biosynthesis enzymes have been knocked out, we are developing small molecule inhibitors

298 LMNA/C, TBX5, MYH7, ANKRD1, and NKX2.5) were knocked out with high efficiency and specificity in huma

299 overexpressing TNBC cells were attenuated by knocking out WNT5A, but could be restored by MMP7 overex

300 opy the increase in fluvastatin sensitivity; knocking out ZEB1 reversed this effect.