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1 citable phenotype similar to the conditional knock-out.
2 ritic complexity is lowest in the homozygous knock-out.
3 surge were overcome by neuron-specific SOCS3 knock-out.
4 was validated by a CRISPR/Cas9 mediated ZnT8 knock-out.
5 s in which the plasminogen receptor (KT) was knocked out.
6 ions when the OG repair glycosylase Ogg1 was knocked out.
7        These pLoF mutations are estimated to knock out 1,317 genes, each in at least one participant.
8                                              Knocking out a homolog of fungal Zn(II)2Cys6-encoding ge
9 e-to-inosine substitution, which selectively knocks out a Watson-Crick-type (G)N2H2...O2(T) hydrogen
10  of Tyr181Cys RT (CRTIs) that can completely knock out activity of the resistant mutant and of the pa
11                                              Knocking out ALC would increase shatter resistance to av
12 sed genome editing offers the possibility to knock out almost any gene of interest in an affordable a
13  CRISPR/Cas9-mediated gene editing to stably knock out and recover Rab8a in macrophage cell lines, we
14 riptomic consequences of PLAG1 deficiency in knock-out and heterozygous mice compared to wild-type mi
15 e and human- disease-allele point mutants or knock-out and knockdown models, we show that disruption
16                                         Both knock-out and overexpression mutants of MtMATE55 showed
17                   Similarly, maternal Slc6a4 knock-out and prenatal stress in rodents results in offs
18                                       Malat1 knock-out and wild-type mice were subjected to 1 h of mi
19 daily sperm production and sperm motility in knock-out and wild-type mice.
20 ensitive to pertussis toxin or beta-arrestin knock-out, and mimicked by Gs-DREADD stimulation, sugges
21 as been called into question or conventional knock-out animal models in which compensatory mechanisms
22                               However, using knock-out animals (of MT-III and vesicular Zn(2+) transp
23 protein abundance in the colon of the Nedd4L knock-out animals was increased, indicating that Nedd4L
24                       Using apolipoprotein E knock-out (apoE(-/-)) mice on a high fat (HF) diet as an
25               Compared with apolipoprotein E knock-out (ApoE(-/-)) mice, which show impaired clearing
26                          Using a conditional knock-out approach to knock out Nedd4L in mice intestina
27 n either beta-cell specific insulin receptor knock-out (betaIRKO) or control mice.
28                                     In SIRT3 knock-out bone marrow-derived macrophages, NLRP3 activat
29 or nuclease gene editing technology, we have knocked out both EVI and MDS/EVI and have shown that EVI
30 ced in HAP1 cells in which the PKD1 gene was knocked out by clustered regularly interspaced short pal
31                                  Blocking or knocking out CCR5 or its ligand CCL5 significantly block
32                  In addition, we generated a knocked-out cell model for ts-101 and ts-46 in HEK-293 c
33 ockdown of both ZDHHC3 and ZDHHC7 in ZDHHC20 knock-out cells decreased endogenous IFITM3 palmitoylati
34       Intracellular Ca(2+) was higher in PC1-knock-out cells than in control cells.
35 ting in 4-fold lower PPARgamma expression in knock-out cells than in wild-type cells.
36              In proximal tubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) a
37 toxymethyl ester) reduced cAMP levels in PC1-knock-out cells.
38 ses, such as axon guidance, we conditionally knocked out Celsr3 in the hippocampus 1 week after birth
39               Using germline and conditional knock-out (cKO) mouse models, we show that Tshz1 is requ
40 Here, O-glycan biosynthesis was truncated by knocking-out Core 1 beta3Gal-T Specific Molecular Chaper
41 DSCs formed significantly less bone in COX-2 knock-out (Cox-2KO) than in COX-2 wild-type (WT) mice.
42                                           We knocked out Ctcf postnatally in glutamatergic forebrain
43                                              Knocking out Ctcf in mouse embryonic neurons is lethal b
44     We created a mouse with conditional Cx26 knock-out (Cx26 cKO) in DCs and PCs that did not influen
45                                 We find that knocking out D2Rs eliminates the ADP in a cell-autonomou
46 lysis of a Pseudomonas aeruginosa quiC1 gene knock-out demonstrates that it is important for growth o
47 lacking the mutation, individuals with APOC3 knocked out displayed marked blunting of the usual post-
48 sclerosis; 2) apoE(-/-)/miR-155(-/-) (double knock-out (DKO)) mice show HF diet-induced obesity, adip
49                                Specifically, knocking out eEF2K in mice eliminated phosphorylation of
50 llular cAMP, we utilized a phosphodiesterase knock-out Escherichia coli strain, DeltacpdA, where inte
51 orphosis in X. tropicalis On the other hand, knocking out EVI and MDS/EVI causes severe retardation i
52                                    AgRP-LepR knock-out female mice exhibited mild obesity and adiposi
53  months of HCD feeding, infertility onset in knock-out females was delayed by 4 weeks.
54 in Drosophila cells in culture, and DJ-1beta knock-out flies, we could detect no contribution of DJ-1
55  congenital myotubular myopathy mouse model (knock-out for the myotubularin coding gene Mtm1) that a
56                                Animal models knocked out for MTM1 show severe reduction of ryanodine
57 n of nude NOD/SCID/IL2rg(-/-) (NSIN) mice by knocking out Foxn1 from NOD/SCID/IL2rg(-/-) (NSI) mice u
58 ed a system where the endogenous TCR-beta is knocked out from the recipient cells using clustered reg
59  that expression of erythropoietin in a GnTI knock-out, FUT8-overexpressing cell line results in the
60          Here, we use CRISPR base editors to knock out genes by changing single nucleotides to create
61 ceptor 1 mediated calcium release but, since knocking out genes in animal models does not necessarily
62 re, we recommend an alternative approach for knocking out genes, which combines CRISPR/Cas9 with gene
63 indromic repeats (CRISPR)/Cas9 technology to knock out GRASP55 and GRASP65, individually or in combin
64           A comparison of WT and Gsk3a;Gsk3b knock-out (Gsk3 DKO) ESCs revealed prominent GSK-3-depen
65                              Behavior of Hdc knock-out (Hdc KO) mice was assessed in an open field te
66 e-editing approach to generate a human COX18 knock-out HEK293T cell line that displays isolated compl
67        Here we demonstrate that CRISPR/Case9 knocking out Hsp90alpha nullifies tumour cells' ability
68                                              Knocking out Hsp90beta leads to tumour cell death.
69 nges in hyperoxia-exposed animals (WT versus knock-out) identified 171 genes unique to Cyp1a1-/- and
70            We found that MMP-3 inhibition or knock-out impaired late-phase LTP in the CA3-CA1 pathway
71 striatonigral but not in the striatopallidal knock-out in response to l-DOPA treatment.Our work shows
72 evelopmental processes, because inducing OGT knock-out in the sensory neurons of adult mice results i
73 172 (glioblastoma multiforme) cell lines and knocked out in HUH7 (liver cancer) cells.
74 ceptor (D1-KO), but not mice where WAVE1 was knocked out in neurons expressing the D2 dopamine recept
75 ssential for Wnt secretion, is conditionally knocked out in the floor plate.
76  all three glucose degradation pathways were knocked out indicate that the ED pathway is physiologica
77 ycanopathy mouse model due to Fukutin (Fktn) knock-out indicated a dose-dependent toxicity.
78                        When these genes were knocked out individually in GGTA1/CMAH DKO RMEC, 32 gene
79                                 Indeed, Sufu knock-out is lethal in mice, and recessive pathogenic va
80                               We have used a knock-out/knock-in strategy in Drosophila to generate a
81 yramidal neurons in the barrel cortex of BC1 knock out (KO) mice display larger excitatory postsynapt
82 e, using RNA-binding protein HuR conditional knock-out (KO) and wild-type (WT) mice, we present evide
83                            Accordingly, E4f1 knock-out (KO) keratinocytes exhibited impaired PDH acti
84 IP14 in manganese homeostasis, we used Zip14 knock-out (KO) male and female mice to conduct comparati
85                                       Ptchd1 knock-out (KO) male mice exhibit cognitive alterations,
86 sponses to whisker stimulation in young Fmr1 knock-out (KO) mice (postnatal days 14-16), a model of F
87 ogical function of CPEB2, we generated CPEB2 knock-out (KO) mice and found that most died within 3 d
88  (HO) and heterozygous (HET) Mybpc3-targeted knock-out (KO) mice we show that crypts (one or two) are
89                                         PAK4 knock-out (KO) mice were born at Mendelian ratios in bot
90                     Wild-type (WT) and TRPC5 knock-out (KO) mice were fed a diet supplemented with 0.
91 aging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to t
92 ion in the heart, we took advantage of MEF2A knock-out (KO) mice, a model that displays a predominant
93                                       In Pml knock-out (KO) mice, ablation of Pml largely reduces IFN
94 ntrast, in hippocampal slices from calpain-1 knock-out (KO) mice, application of the mGluR agonist, D
95 APOE-targeted-replacement (APOE-TR) and APOE-knock-out (KO) mice, with neuroinflammation induced by l
96 upregulation of NMDARs, we also analyzed PrP knock-out (KO) mice.
97 ied their roles using global and conditional knock-out (KO) mice.
98  L2/3 pyramidal neurons in adult V1 of Lynx1 knock-out (KO) mice.
99 erated a novel skeletal muscle-specific GRK2 knock-out (KO) mouse (MLC-Cre:GRK2(fl/fl)) to gain a bet
100         We used conditional and conventional knock-out (KO) mouse lines, with viral expression of Cre
101 nus neurotoxin (TeNT), also in TI-VAMP/VAMP7 knock-out (KO) neurons).
102  applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then analyzed the c
103 rinking using the following models: (1) Tlr4 knock-out (KO) rats, (2) selective knockdown of Tlr4 mRN
104  Here we report that mice in which WAVE1 was knocked out (KO) in neurons expressing the D1 dopamine r
105 andom integrants for purposes including gene knock-out libraries, screening for optimal integration p
106 ession profiles of a mouse p38alpha (Mapk14) knock-out line to the original wild-type.
107 he main contributor to the MGPA as grains of knock-out lines show very low MGPA.
108                          We found that PRMT1 knock-out macrophages failed to up-regulate PPARgamma ex
109         In support of this mechanism, eEF-2K knock-out MCF10A cells reconstituted with eEF-2K S500D d
110 x assays combined with pharmacology and gene knock-out methods, we discovered a previously unrecogniz
111 L-6, IL-1beta, and ccl5 in the skin of IFNAR knock out mice following subcutaneous administration.
112                       In beta2-microglobulin knock out mice, the D76N beta2-microglobulin/ Nb24 pre-f
113                          In Cx26 conditional knock-out mice (Cx26(Sox10-Cre)), the maturation of IHCs
114 t-specific protein-1 driven conditional Cx43 knock-out mice (Cx43fsp1KO).
115    We used male and female heterozygous Gnal knock-out mice (Gnal(+/-)) to study how GNAL haplodefici
116 s in R1a subunit expression are seen in Fmr1 knock-out mice (KO) mice, a widely used animal model of
117  cardiac fibroblasts isolated from PI3Kgamma knock-out mice (PI3KgammaKO) showed decreased insulin-st
118                    Using both transgenic and knock-out mice along with in vitro assays, our data show
119 thionine biosynthesis by constructing LanCL1 knock-out mice and measuring LK concentrations in their
120 ype previously reported in alphaB-crystallin knock-out mice and suggests that the elevated chaperone
121  recordings from hippocampal neurons of KCTD knock-out mice are consistent with these findings and in
122 at the phenotypical changes in collagen XIII knock-out mice are milder than symptoms in human patient
123 s, several neurological phenotypes of R7-RGS knock-out mice are not readily explained by dysregulated
124         Furthermore, adipose-specific Dnmt3a knock-out mice are protected from diet-induced insulin r
125 nese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biolo
126                        LTD was absent in CB1 knock-out mice but preserved in heterozygous littermates
127 ST were up to 2.7 times greater in alphaENaC knock-out mice compared with the respective field volume
128 s or a control vector into the CeA of orexin knock-out mice crossed with vGAT-Cre mice, resulting in
129        We showed that myeloid-specific PRMT1 knock-out mice demonstrate higher proinflammatory cytoki
130 e experiments on kisspeptin-specific ERalpha knock-out mice demonstrate that ERalpha in kisspeptin ce
131                            Analyses of Tulp1 knock-out mice demonstrate that Tulp1 is essential to ke
132       Selective antagonists and neurons from knock-out mice demonstrated a BLT1-dependent sensitizati
133 ely 800-1000-fold), indicating that Slc30a10 knock-out mice develop hypothyroidism.
134                                          uPA-knock-out mice developed fewer and smaller TSC2-null lun
135                         The Dlx1/Dlx2 double knock-out mice die at birth with abnormal cortical devel
136                           Ric-8b conditional knock-out mice display impaired olfactory guided behavio
137 es CerS3 activity, whereas cytosol from ACBP knock-out mice does not.
138                                        Pcmt1 knock-out mice exhibit a profound neuropathology and die
139 avioral analyses show that PRMT8 conditional knock-out mice exhibit impaired hippocampal-dependent fe
140  hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a comprehensive brake in their
141 r, after weaning and compared with controls, knock-out mice failed to gain weight, were smaller, and
142 (PcTx1) and the absence of these currents in knock-out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest
143 rated inducible and skeletal muscle-specific knock-out mice for Rheb (iRhebKO) and TSC2 (iTSC2KO) and
144  both inducible and skeletal muscle-specific knock-out mice for Rheb and iTSC2KO mice.
145           Unfortunately, the available P2RX7 knock-out mice generated by pharmaceutical companies pos
146    Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after bi
147 lowing AKAP siRNA transfection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685 phosp
148                  Although Cdkl5 constitutive knock-out mice have recapitulated key aspects of human s
149 r studies performed on P2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are involved in t
150          Accordingly, the neuroretina of PrP-knock-out mice is iron-deficient.
151      We found that olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf
152                                  Adiponectin knock-out mice receiving dextran sulfate sodium exhibite
153               Given that the receptor double knock-out mice resemble reeler mutants, we infer that Re
154 xogenous expression of human Stbd1 in double knock-out mice restored the liver lysosomal glycogen con
155  of the vertebrate P3H family, P3h3 and Sc65 knock-out mice revealed a common lysine under-hydroxylat
156 ts showed that the olfactory-specific Ric-8b knock-out mice show an impaired sense of smell, even tho
157       Furthermore, we report that aged APLP1 knock-out mice show impaired basal transmission and a re
158 holesterol atherogenic diet-challenged Sort1 knock-out mice showed less hepatic free cholesterol accu
159 of cultured neurons from wild-type and SUMO1 knock-out mice showed that anti-SUMO1 immunolabelling at
160 sma analyses of single-proprotein convertase-knock-out mice showed that loss of the convertase furin
161 yte-specific furin, PC5/6, or complete PACE4 knock-out mice suggested that the cleavage of overexpres
162                                 Furthermore, knock-out mice that lack PLK2 (the predominant kinase th
163                                Generation of knock-out mice that lacked PEMT showed that they were pr
164                      We then use conditional knock-out mice to eliminate FMRP only in the PFC alone o
165          Here, we produced Dgcr8 conditional knock-out mice using progesterone receptor (PR)-Cre (Dgc
166    Paradoxically, excitability in kisspeptin knock-out mice was similar to the maximum observed in co
167                                  Adiponectin knock-out mice were orally administered dextran sulfate
168    Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperar
169                                              Knock-out mice without functional mGluR5 exhibit severe
170 sosomal glycogen content to the level of GAA knock-out mice, as did a mutant lacking the Atg8 family
171 ogenesis were downregulated in the testes of knock-out mice, as well as Hsd17b3, which encodes a key
172 combinant TRX in wild-type mice, but not TG2 knock-out mice, led to a rapid rise in intestinal transg
173 by using anti-murine Abeta antibodies or APP knock-out mice, prevents the cGMP-dependent enhancement
174 preoptic nucleus of fever-refractive mPGES-1 knock-out mice, resulted in a temperature elevation in r
175 rrel cortex activity in young and adult Fmr1 knock-out mice, the mouse model of fragile X syndrome (F
176              In Exoc5 photoreceptor-specific knock-out mice, the photoreceptor outer segment structur
177     Taking advantage of the conditional Oxtr knock-out mice, the present study highlights the importa
178 hippocampal cultures from Arp2/3 conditional knock-out mice, we analyze the roles of the Arp2/3 compl
179                       Using conditional Gdnf knock-out mice, we found that endogenous GDNF affects st
180                      Here, using conditional knock-out mice, we show that hippocampal-dependent learn
181                               Using connexin knock-out mice, we show that IHCs fire spontaneous actio
182  nutrient deprivation in wild-type and SIRT3 knock-out mice.
183 d spread of labels were greater in alphaENaC knock-out mice.
184 ocampal-dependent memory in male conditional knock-out mice.
185 BLT1 and TRPV1 as shown using the respective knock-out mice.
186 ontrol experiments showed no labeling of TG2 knock-out mice.
187 sh mutants, and photoreceptor-specific Exoc5 knock-out mice.
188 on of these molecules was observed in ERK1/2 knock-out mice.
189 hibition of HDAC6 reduced cyst growth in PC1-knock-out mice.
190 lammasome in wild-type mice but not in SIRT3 knock-out mice.
191 ence in survival between wild-type and PRMT1 knock-out mice.
192 notype was similarly severe in each of these knock-out mice.
193 onset of learning in both FX and conditional knock-out mice.
194 ce neutrophil apoptosis was impaired in AnxA-knock-out mice.
195 , Rag2(-/-), and Rag2(-/-)xParp1(-/-) double knock-out mice.
196 rent was lacking in DGGCs from delta-subunit knock-out mice.
197 triggered a vigorous immune response in ZnT8 knock-out mice.
198 tes to the infection susceptibility in PRMT1 knock-out mice.
199 Cdc42, we generated myeloid-restricted Cdc42 knock-out mice.
200 ct against cholesterol lipotoxicity in Sort1 knock-out mice.
201 that have previously been reported in VGLUT3 knock-out mice.
202 manifestations of EAE disappeared in miR-142 knock-out mice.
203 at the organism level, we generated Slc30a10 knock-out mice.
204   We have established the first glyoxalase 1 knock-out model (GLO1(-/-)) in mammalian Schwann cells u
205                        Here, we used a mouse knock-out model in which the transduction component used
206 address this question, we generated cellular knock-out models of FA core complex components and FANCD
207  have generated a T cell-specific Coronin 1a knock-out mouse (Coro1a(fl/fl) x Cd4[Cre]).
208 c-8b in vivo, we generated a tissue specific knock-out mouse by crossing OMP-Cre transgenic mice to R
209                                  Adiponectin knock-out mouse colons had markedly reduced proliferatio
210 ls in the forebrains of the Dlx1/Dlx2 double knock-out mouse in vivo Identification of Gad genes as d
211 ation, we generated an inducible conditional knock-out mouse in which the L-VGCC isoform Cav1.2 was d
212 se of a conditional, hepatocyte-targeted AHR knock-out mouse model (Cre(Alb)Ahr(Fx/Fx)).
213 athology, we generated a heterozygous Pabpn1 knock-out mouse model (Pabpn1+/Delta).
214 We developed and characterized a conditional knock-out mouse model and found that GSKIP deficiency ca
215 own to ameliorate mitochondrial disease in a knock-out mouse model lacking a nuclear-encoded gene spe
216 analyzed brain structure in a maternal Ube3a knock-out mouse model of AS.
217  by studying an inducible SC-specific Gpr126 knock-out mouse model.
218 ses in vivo, we created a cell type-specific knock-out mouse model.
219                Thus, we generated a Slc25a46 knock-out mouse model.
220 e generated a cardiac-specific and inducible knock-out mouse model.
221                        Fibroblasts from Optn knock-out mouse showed reduced LC3-II formation and a lo
222 rther examined the role of COX2 using a COX2-knock-out mouse where pFUS was unable to increase MSC tr
223     Using a new alphaII spectrin conditional knock-out mouse, we show that alphaII spectrin is requir
224 ng the specific Gq inhibitor, UBO-QIC, or Gq knock-out murine platelets, we demonstrate that Gq signa
225 sed in transgenic plants of a PORB-deficient knock-out mutant (porB) of Arabidopsis thaliana.
226  promotes root elongation, whereas AtbHLH112 knock-out mutant displays an opposite phenotype.
227 infected with a wild-type IAV and its PB1-F2 knock-out mutant for analyses at different times post-in
228 dying peripheral myelinated fibers in Schip1 knock-out mutant mice.
229                                    In a gldh knock-out mutant, complex I is not detectable, suggestin
230                                        T-DNA knock-out mutants of At3g57630 showed a truncated root h
231                                     The true knock-out mutants of MPK1 were severely dwarfed and ster
232 month-old) Gba1 mouse models, one carrying a knock-out mutation and the other a L444P knock-in mutati
233    Using a conditional knock-out approach to knock out Nedd4L in mice intestinal epithelium (Nedd4L(f
234               We found that homozygous Celf1 knock-out neonates exhibited cardiac dysfunction not obs
235                                  Previously, knock-out of Arhgef18 in the medaka fish has been shown
236   In support of this hypothesis, conditional knock-out of ARPP-16 in CaMKIIalpha::cre/floxed ARPP-16/
237                                  Conditional knock-out of ARPP-16/19 is associated with increased mot
238                         Finally, conditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expres
239 er in the expression of LID, the kinase CK2: knock-out of CK2 in striatonigral and striatopallidal ne
240                          We report here that knock-out of CK2 in striatonigral neurons reduces the se
241                       We discovered that the knock-out of HO in P. berghei is lethal; therefore, we i
242                                 Accordingly, knock-out of HuR reduced CCR6 expression on Th17 cells a
243                                       Unlike knock-out of individual ZDHHCs, siRNA-mediated knockdown
244                                              Knock-out of MICAL3 leads to an increased frequency of c
245                         Accordingly, genetic knock-out of mouse ShcD enhances Erk phosphorylation in
246 ten requires overexpression, knock-down, and knock-out of multiple gene targets.
247                      Sensory neuron-specific knock-out of OGT results in behavioral hyposensitivity t
248 sion of PCBP2 inhibits, whereas knockdown or knock-out of PCBP2 increases, the production of reactive
249 Sox2, Oct4 (Pou5f1), Nanog], and conditional knock-out of Sox2 during fracture healing results in red
250         We therefore generated a conditional knock-out of the NADPH-P450 oxidoreductase (Por) gene co
251                             As expected, the knock-out of TSC2 led to an elevation in the basal level
252  by torin 1, or CRISPR/Cas9-mediated genetic knock-out of tuberous sclerosis complex-2 (Tsc2) blocked
253       Notch1, a known ADAM10 substrate, when knocked out of DCs (Notch1(DC)(-/-) ) demonstrated a sim
254  was either genetically or pharmacologically knocked out or genetically overexpressed in cardiomyocyt
255 ice and SH-SY5Y cell models, we specifically knocked out or knocked down gene expression of mapk14, w
256 d in human and mouse cells while selectively knocking out or down critical BER proteins to identify t
257 phenotypes could be reproduced or rescued by knocking out or restoring BMAL1 exclusively in skeletal
258 singly, when K(ATP) channels are genetically knocked out, oscillations in islet activity persist, and
259                                         glt1-knock-out parasites exhibited a growth defect not rescue
260 o in the context of mitochondrial damage, we knocked out Parkin in a mouse model in which the mitocho
261  on mitochondrial quality control in vivo by knocking out Parkin in the PD-mito-PstI mouse (males), w
262 report results obtained with conditional PC4 knock-out (PC4(f/f) Nestin-Cre) mice where PC4 is knocke
263 ted to peroxisome membranes could rescue the knock out phenotype and interacted with Fission1 on the
264 s the changes in circadian period evident in knock-out phenotypes and individuals with PER3-related c
265         CRISPR/Cas9 gene editing was used to knock out pig conceptus IL1B2 expression and the secreti
266                         MMP-3 inhibition and knock-out prevented the induction of vdccLTP, with no ef
267 butes to the proliferative phenotype of Spop knock-out prostates.
268 icantly lower in mid-aged (>10-month-old) PV-knock out (PV-KO) mice.
269 ts obtained from skin of heterozygous Ndufc2 knock-out rat model showed marked mitochondrial dysfunct
270 ted cell line model systems, and a GalNAc-T2 knock-out rat model, we show that GalNAc-T2 co-regulates
271                                  Spinophilin knock-out results in enhanced mGluR5 endocytosis as well
272                           Pooled CRISPR-Cas9 knock out screens provide a valuable addition to the met
273 oding a genome-editing agent can efficiently knock-out selected genes in anti-cancer T-cells.
274 easibility of CRISPR-Trap by utilizing it to knock out several genes in different human cell lines.
275 A bound to live INS-1E cells, whereas a ZnT8 knock-out specifically reduced the surface binding.
276 -out (PC4(f/f) Nestin-Cre) mice where PC4 is knocked out specifically in the brain.
277                                              Knocking out spineless using CRISPR/Cas9 leads to the lo
278  the role of FplA, we developed an fplA gene knock-out strain, which will guide future in vivo studie
279 -fold changes in expression level in an OmpR knock-out strain.
280 bolic differences akin to those generated by knock-out strains engineered in the laboratory used to e
281                                     Genetic (knock-out) studies indicate that the derived diterpenoid
282 expressed in multiple cancers, and the PYCR1 knock-out suppresses tumorigenic growth, suggesting that
283 l and hippocampal tissues isolated from T1R3 knock-out (T1R3KO) mice.
284 ield stimulation, the patch-clamp method and knock-out technology, we determined the sources and cons
285  inhibitor of SM synthase or using CRISPR to knock out the Sms2 gene recapitulated the palmitate effe
286  glial fibrillary acidic protein promoter to knock out the transcription factor signal transducer and
287 mulation can be engineered in A. thaliana by knocking out the HAC1 gene and expressing PvACR3.
288                           Here, we show that knocking out the Ras homolog family member A (RhoA) gene
289                        Indeed, we found that knocking out these genes caused a number of chloroplast
290  We find that PTP is unchanged in PKC triple knock-out (TKO) mice in which all calcium-dependent PKC
291 /3) may confer a compensatory effect, triple knock-out (TKO) mice were also generated and tested.
292 (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, TKO and wild type (WT) mouse brains, suggesti
293 s dyskinesia in animals with striatopallidal knock-out to wild-type levels, suggesting a dependence o
294 le-positive, non-target NCI-H358-HER2 CRISPR knock out tumors in nude mice bearing dual-flank tumor x
295 atient-specific differences were mimicked by knocking out UBE3A using CRISPR/Cas9 or by knocking down
296 (-/-) pregnant mice alleviated the effect of knocking out UCP2 on pancreas development.
297  carbohydrate biosynthesis enzymes have been knocked out, we are developing small molecule inhibitors
298 LMNA/C, TBX5, MYH7, ANKRD1, and NKX2.5) were knocked out with high efficiency and specificity in huma
299 overexpressing TNBC cells were attenuated by knocking out WNT5A, but could be restored by MMP7 overex
300 opy the increase in fluvastatin sensitivity; knocking out ZEB1 reversed this effect.

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