コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 citable phenotype similar to the conditional knock-out.
2 ritic complexity is lowest in the homozygous knock-out.
3 surge were overcome by neuron-specific SOCS3 knock-out.
4 was validated by a CRISPR/Cas9 mediated ZnT8 knock-out.
5 s in which the plasminogen receptor (KT) was knocked out.
6 ions when the OG repair glycosylase Ogg1 was knocked out.
9 e-to-inosine substitution, which selectively knocks out a Watson-Crick-type (G)N2H2...O2(T) hydrogen
10 of Tyr181Cys RT (CRTIs) that can completely knock out activity of the resistant mutant and of the pa
12 sed genome editing offers the possibility to knock out almost any gene of interest in an affordable a
13 CRISPR/Cas9-mediated gene editing to stably knock out and recover Rab8a in macrophage cell lines, we
14 riptomic consequences of PLAG1 deficiency in knock-out and heterozygous mice compared to wild-type mi
15 e and human- disease-allele point mutants or knock-out and knockdown models, we show that disruption
20 ensitive to pertussis toxin or beta-arrestin knock-out, and mimicked by Gs-DREADD stimulation, sugges
21 as been called into question or conventional knock-out animal models in which compensatory mechanisms
23 protein abundance in the colon of the Nedd4L knock-out animals was increased, indicating that Nedd4L
29 or nuclease gene editing technology, we have knocked out both EVI and MDS/EVI and have shown that EVI
30 ced in HAP1 cells in which the PKD1 gene was knocked out by clustered regularly interspaced short pal
33 ockdown of both ZDHHC3 and ZDHHC7 in ZDHHC20 knock-out cells decreased endogenous IFITM3 palmitoylati
38 ses, such as axon guidance, we conditionally knocked out Celsr3 in the hippocampus 1 week after birth
40 Here, O-glycan biosynthesis was truncated by knocking-out Core 1 beta3Gal-T Specific Molecular Chaper
41 DSCs formed significantly less bone in COX-2 knock-out (Cox-2KO) than in COX-2 wild-type (WT) mice.
44 We created a mouse with conditional Cx26 knock-out (Cx26 cKO) in DCs and PCs that did not influen
46 lysis of a Pseudomonas aeruginosa quiC1 gene knock-out demonstrates that it is important for growth o
47 lacking the mutation, individuals with APOC3 knocked out displayed marked blunting of the usual post-
48 sclerosis; 2) apoE(-/-)/miR-155(-/-) (double knock-out (DKO)) mice show HF diet-induced obesity, adip
50 llular cAMP, we utilized a phosphodiesterase knock-out Escherichia coli strain, DeltacpdA, where inte
51 orphosis in X. tropicalis On the other hand, knocking out EVI and MDS/EVI causes severe retardation i
54 in Drosophila cells in culture, and DJ-1beta knock-out flies, we could detect no contribution of DJ-1
55 congenital myotubular myopathy mouse model (knock-out for the myotubularin coding gene Mtm1) that a
57 n of nude NOD/SCID/IL2rg(-/-) (NSIN) mice by knocking out Foxn1 from NOD/SCID/IL2rg(-/-) (NSI) mice u
58 ed a system where the endogenous TCR-beta is knocked out from the recipient cells using clustered reg
59 that expression of erythropoietin in a GnTI knock-out, FUT8-overexpressing cell line results in the
61 ceptor 1 mediated calcium release but, since knocking out genes in animal models does not necessarily
62 re, we recommend an alternative approach for knocking out genes, which combines CRISPR/Cas9 with gene
63 indromic repeats (CRISPR)/Cas9 technology to knock out GRASP55 and GRASP65, individually or in combin
66 e-editing approach to generate a human COX18 knock-out HEK293T cell line that displays isolated compl
69 nges in hyperoxia-exposed animals (WT versus knock-out) identified 171 genes unique to Cyp1a1-/- and
71 striatonigral but not in the striatopallidal knock-out in response to l-DOPA treatment.Our work shows
72 evelopmental processes, because inducing OGT knock-out in the sensory neurons of adult mice results i
74 ceptor (D1-KO), but not mice where WAVE1 was knocked out in neurons expressing the D2 dopamine recept
76 all three glucose degradation pathways were knocked out indicate that the ED pathway is physiologica
81 yramidal neurons in the barrel cortex of BC1 knock out (KO) mice display larger excitatory postsynapt
82 e, using RNA-binding protein HuR conditional knock-out (KO) and wild-type (WT) mice, we present evide
84 IP14 in manganese homeostasis, we used Zip14 knock-out (KO) male and female mice to conduct comparati
86 sponses to whisker stimulation in young Fmr1 knock-out (KO) mice (postnatal days 14-16), a model of F
87 ogical function of CPEB2, we generated CPEB2 knock-out (KO) mice and found that most died within 3 d
88 (HO) and heterozygous (HET) Mybpc3-targeted knock-out (KO) mice we show that crypts (one or two) are
91 aging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to t
92 ion in the heart, we took advantage of MEF2A knock-out (KO) mice, a model that displays a predominant
94 ntrast, in hippocampal slices from calpain-1 knock-out (KO) mice, application of the mGluR agonist, D
95 APOE-targeted-replacement (APOE-TR) and APOE-knock-out (KO) mice, with neuroinflammation induced by l
99 erated a novel skeletal muscle-specific GRK2 knock-out (KO) mouse (MLC-Cre:GRK2(fl/fl)) to gain a bet
102 applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then analyzed the c
103 rinking using the following models: (1) Tlr4 knock-out (KO) rats, (2) selective knockdown of Tlr4 mRN
104 Here we report that mice in which WAVE1 was knocked out (KO) in neurons expressing the D1 dopamine r
105 andom integrants for purposes including gene knock-out libraries, screening for optimal integration p
110 x assays combined with pharmacology and gene knock-out methods, we discovered a previously unrecogniz
111 L-6, IL-1beta, and ccl5 in the skin of IFNAR knock out mice following subcutaneous administration.
115 We used male and female heterozygous Gnal knock-out mice (Gnal(+/-)) to study how GNAL haplodefici
116 s in R1a subunit expression are seen in Fmr1 knock-out mice (KO) mice, a widely used animal model of
117 cardiac fibroblasts isolated from PI3Kgamma knock-out mice (PI3KgammaKO) showed decreased insulin-st
119 thionine biosynthesis by constructing LanCL1 knock-out mice and measuring LK concentrations in their
120 ype previously reported in alphaB-crystallin knock-out mice and suggests that the elevated chaperone
121 recordings from hippocampal neurons of KCTD knock-out mice are consistent with these findings and in
122 at the phenotypical changes in collagen XIII knock-out mice are milder than symptoms in human patient
123 s, several neurological phenotypes of R7-RGS knock-out mice are not readily explained by dysregulated
125 nese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biolo
127 ST were up to 2.7 times greater in alphaENaC knock-out mice compared with the respective field volume
128 s or a control vector into the CeA of orexin knock-out mice crossed with vGAT-Cre mice, resulting in
130 e experiments on kisspeptin-specific ERalpha knock-out mice demonstrate that ERalpha in kisspeptin ce
139 avioral analyses show that PRMT8 conditional knock-out mice exhibit impaired hippocampal-dependent fe
140 hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a comprehensive brake in their
141 r, after weaning and compared with controls, knock-out mice failed to gain weight, were smaller, and
142 (PcTx1) and the absence of these currents in knock-out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest
143 rated inducible and skeletal muscle-specific knock-out mice for Rheb (iRhebKO) and TSC2 (iTSC2KO) and
146 Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after bi
147 lowing AKAP siRNA transfection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685 phosp
149 r studies performed on P2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are involved in t
151 We found that olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf
154 xogenous expression of human Stbd1 in double knock-out mice restored the liver lysosomal glycogen con
155 of the vertebrate P3H family, P3h3 and Sc65 knock-out mice revealed a common lysine under-hydroxylat
156 ts showed that the olfactory-specific Ric-8b knock-out mice show an impaired sense of smell, even tho
158 holesterol atherogenic diet-challenged Sort1 knock-out mice showed less hepatic free cholesterol accu
159 of cultured neurons from wild-type and SUMO1 knock-out mice showed that anti-SUMO1 immunolabelling at
160 sma analyses of single-proprotein convertase-knock-out mice showed that loss of the convertase furin
161 yte-specific furin, PC5/6, or complete PACE4 knock-out mice suggested that the cleavage of overexpres
166 Paradoxically, excitability in kisspeptin knock-out mice was similar to the maximum observed in co
168 Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperar
170 sosomal glycogen content to the level of GAA knock-out mice, as did a mutant lacking the Atg8 family
171 ogenesis were downregulated in the testes of knock-out mice, as well as Hsd17b3, which encodes a key
172 combinant TRX in wild-type mice, but not TG2 knock-out mice, led to a rapid rise in intestinal transg
173 by using anti-murine Abeta antibodies or APP knock-out mice, prevents the cGMP-dependent enhancement
174 preoptic nucleus of fever-refractive mPGES-1 knock-out mice, resulted in a temperature elevation in r
175 rrel cortex activity in young and adult Fmr1 knock-out mice, the mouse model of fragile X syndrome (F
177 Taking advantage of the conditional Oxtr knock-out mice, the present study highlights the importa
178 hippocampal cultures from Arp2/3 conditional knock-out mice, we analyze the roles of the Arp2/3 compl
204 We have established the first glyoxalase 1 knock-out model (GLO1(-/-)) in mammalian Schwann cells u
206 address this question, we generated cellular knock-out models of FA core complex components and FANCD
208 c-8b in vivo, we generated a tissue specific knock-out mouse by crossing OMP-Cre transgenic mice to R
210 ls in the forebrains of the Dlx1/Dlx2 double knock-out mouse in vivo Identification of Gad genes as d
211 ation, we generated an inducible conditional knock-out mouse in which the L-VGCC isoform Cav1.2 was d
214 We developed and characterized a conditional knock-out mouse model and found that GSKIP deficiency ca
215 own to ameliorate mitochondrial disease in a knock-out mouse model lacking a nuclear-encoded gene spe
222 rther examined the role of COX2 using a COX2-knock-out mouse where pFUS was unable to increase MSC tr
223 Using a new alphaII spectrin conditional knock-out mouse, we show that alphaII spectrin is requir
224 ng the specific Gq inhibitor, UBO-QIC, or Gq knock-out murine platelets, we demonstrate that Gq signa
227 infected with a wild-type IAV and its PB1-F2 knock-out mutant for analyses at different times post-in
232 month-old) Gba1 mouse models, one carrying a knock-out mutation and the other a L444P knock-in mutati
233 Using a conditional knock-out approach to knock out Nedd4L in mice intestinal epithelium (Nedd4L(f
236 In support of this hypothesis, conditional knock-out of ARPP-16 in CaMKIIalpha::cre/floxed ARPP-16/
239 er in the expression of LID, the kinase CK2: knock-out of CK2 in striatonigral and striatopallidal ne
248 sion of PCBP2 inhibits, whereas knockdown or knock-out of PCBP2 increases, the production of reactive
249 Sox2, Oct4 (Pou5f1), Nanog], and conditional knock-out of Sox2 during fracture healing results in red
252 by torin 1, or CRISPR/Cas9-mediated genetic knock-out of tuberous sclerosis complex-2 (Tsc2) blocked
254 was either genetically or pharmacologically knocked out or genetically overexpressed in cardiomyocyt
255 ice and SH-SY5Y cell models, we specifically knocked out or knocked down gene expression of mapk14, w
256 d in human and mouse cells while selectively knocking out or down critical BER proteins to identify t
257 phenotypes could be reproduced or rescued by knocking out or restoring BMAL1 exclusively in skeletal
258 singly, when K(ATP) channels are genetically knocked out, oscillations in islet activity persist, and
260 o in the context of mitochondrial damage, we knocked out Parkin in a mouse model in which the mitocho
261 on mitochondrial quality control in vivo by knocking out Parkin in the PD-mito-PstI mouse (males), w
262 report results obtained with conditional PC4 knock-out (PC4(f/f) Nestin-Cre) mice where PC4 is knocke
263 ted to peroxisome membranes could rescue the knock out phenotype and interacted with Fission1 on the
264 s the changes in circadian period evident in knock-out phenotypes and individuals with PER3-related c
269 ts obtained from skin of heterozygous Ndufc2 knock-out rat model showed marked mitochondrial dysfunct
270 ted cell line model systems, and a GalNAc-T2 knock-out rat model, we show that GalNAc-T2 co-regulates
274 easibility of CRISPR-Trap by utilizing it to knock out several genes in different human cell lines.
275 A bound to live INS-1E cells, whereas a ZnT8 knock-out specifically reduced the surface binding.
278 the role of FplA, we developed an fplA gene knock-out strain, which will guide future in vivo studie
280 bolic differences akin to those generated by knock-out strains engineered in the laboratory used to e
282 expressed in multiple cancers, and the PYCR1 knock-out suppresses tumorigenic growth, suggesting that
284 ield stimulation, the patch-clamp method and knock-out technology, we determined the sources and cons
285 inhibitor of SM synthase or using CRISPR to knock out the Sms2 gene recapitulated the palmitate effe
286 glial fibrillary acidic protein promoter to knock out the transcription factor signal transducer and
290 We find that PTP is unchanged in PKC triple knock-out (TKO) mice in which all calcium-dependent PKC
291 /3) may confer a compensatory effect, triple knock-out (TKO) mice were also generated and tested.
292 (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, TKO and wild type (WT) mouse brains, suggesti
293 s dyskinesia in animals with striatopallidal knock-out to wild-type levels, suggesting a dependence o
294 le-positive, non-target NCI-H358-HER2 CRISPR knock out tumors in nude mice bearing dual-flank tumor x
295 atient-specific differences were mimicked by knocking out UBE3A using CRISPR/Cas9 or by knocking down
297 carbohydrate biosynthesis enzymes have been knocked out, we are developing small molecule inhibitors
298 LMNA/C, TBX5, MYH7, ANKRD1, and NKX2.5) were knocked out with high efficiency and specificity in huma
299 overexpressing TNBC cells were attenuated by knocking out WNT5A, but could be restored by MMP7 overex
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。