ライフサイエンスコーパス: knock-out mice

1 to lysosomes, we generated GAA/Stbd1 double knock-out mice.

2 AR by using a set of specific inhibitors and knock-out mice.

3 in Trpv4 keratinocyte-specific and inducible knock-out mice.

4 Recovery was also delayed in IL-10 knock-out mice.

5 ed with conventional (whole body) Coronin 1a knock-out mice.

6 and apoA-IV expression in liver-specific MTP knock-out mice.

7 inimal radiotracer uptake was present in sEH knock-out mice.

8 tes to the infection susceptibility in PRMT1 knock-out mice.

9 Cdc42, we generated myeloid-restricted Cdc42 knock-out mice.

10 vesicles after depletion recover normally in knock-out mice.

11 sent from hippocampal slices of CB2 receptor knock-out mice.

12 expression were also increased in the double knock-out mice.

13 expressed at high levels in testes from Mtdh knock-out mice.

14 ne expression were markedly reduced in these knock-out mice.

15 ct against cholesterol lipotoxicity in Sort1 knock-out mice.

16 not Fcgamma-receptor or neonatal Fc-receptor knock-out mice.

17 evealed significant CST regeneration in NgR1 knock-out mice.

18 ers from wild-type mice but not in p47(phox) knock-out mice.

19 that have previously been reported in VGLUT3 knock-out mice.

20 reported to exert its effect also in PKMzeta knock-out mice.

21 on with small inhibitory RNA, and cells from knock-out mice.

22 vascular permeability/inflammation in sdc-1 knock-out mice.

23 manifestations of EAE disappeared in miR-142 knock-out mice.

24 in neurons cultured from mu-opioid receptor knock-out mice.

25 gene to produce the first conditional EAAT2 knock-out mice.

26 ferator-activated receptor alpha (PPARalpha) knock-out mice.

27 pocampal neurons and brain tissue from Fbxo2 knock-out mice.

28 ChR agonist), and was absent in alpha7 nAChR knock-out mice.

29 at the organism level, we generated Slc30a10 knock-out mice.

30 re potentiated by VU0238429 and absent in M5 knock-out mice.

31 n erythrocytes from pannexin 1 wild type and knock-out mice.

32 in lung was subsequently studied using LCAD knock-out mice.

33 using conditional, tamoxifen-inducible Hif1a knock-out mice.

34 characteristics in adult male, GnRH receptor knock-out mice.

35 e able to protect neurons derived from HDAC8 knock-out mice.

36 D in the CA1 hippocampus of Grf1/Grf2 double knock-out mice.

37 n levels were decreased in livers from KLF14 knock-out mice.

38 n a variety of tissues and ubqln conditional knock-out mice.

39 nd that this response is diminished in Smad3 knock-out mice.

40 but not abolished, among cells of connexin36 knock-out mice.

41 nd largely absent in platelets from PKCalpha knock-out mice.

42 eractivity exhibited by dopamine transporter knock-out mice.

43 cultured neurons derived from synaptophysin knock-out mice.

44 pocampal cultures derived from AMPAR subunit knock-out mice.

45 failed to increase secretory capacity in NPY knock-out mice.

46 ved neutrophils from Fut4(-/-)Fut7(-/-) dual knock-out mice.

47 from AngII-treated wild type mice and AT-1R knock-out mice.

48 e observed in Task-1(-/-)/Task-3(-/-) double knock-out mice.

49 nutrient deprivation in wild-type and SIRT3 knock-out mice.

50 d spread of labels were greater in alphaENaC knock-out mice.

51 ocampal-dependent memory in male conditional knock-out mice.

52 BLT1 and TRPV1 as shown using the respective knock-out mice.

53 sh mutants, and photoreceptor-specific Exoc5 knock-out mice.

54 ontrol experiments showed no labeling of TG2 knock-out mice.

55 on of these molecules was observed in ERK1/2 knock-out mice.

56 hibition of HDAC6 reduced cyst growth in PC1-knock-out mice.

57 lammasome in wild-type mice but not in SIRT3 knock-out mice.

58 ence in survival between wild-type and PRMT1 knock-out mice.

59 notype was similarly severe in each of these knock-out mice.

60 ce neutrophil apoptosis was impaired in AnxA-knock-out mice.

61 onset of learning in both FX and conditional knock-out mice.

62 triggered a vigorous immune response in ZnT8 knock-out mice.

63 , Rag2(-/-), and Rag2(-/-)xParp1(-/-) double knock-out mice.

64 rent was lacking in DGGCs from delta-subunit knock-out mice.

65 estine-specific and liver-specificLpcat3gene knock-out mice.

66 ake values wild-type versus apolipoprotein E knock out mice, 0.05 +/- 0.01 versus 0.17 +/- 0.01, P<0.

67 uced microglia counts in the brains of MECP2 knock-out mice; (2) proliferation of mitochondria and en

68 fferentiated from neural progenitors of Fmr1 knock-out mice, a mouse model for FXS, and that tPA is i

69 Prx2 was detected in erythrocytes from Grx1 knock-out mice after peroxide challenge.

70 Using both transgenic and knock-out mice along with in vitro assays, our data show

71 6Ala-Gpx4(+/-)) and crossed them with Alox15 knock-out mice (Alox15(-/-)).

72 pha1alpha2(lox/lox)) and liver-specific AMPK knock-out mice (alpha1alpha2(lox/lox) + Albcre) in the p

73 Galectin-3 knock-out mice also developed LV hypertrophy but without

74 The conditional knock-out mice also exhibited an increased density of ol

75 Tau was required, as crossing with tau knock-out mice also prevented both Kv4.2 depletion and d

76 The knock-out mice also show decrease in both basal and xeno

77 ges isolated from myeloid cell-specific LKB1 knock out mice and their wild type littermate control mi

78 this hypothesis, we here generated (1) Syt12 knock-out mice and (2) Syt12 knockin mice carrying a sin

79 m stellate cells in triple NL123 conditional knock-out mice and analyzed synaptic responses by acute

80 radiopharmaceutical, was evaluated in alpha4 knock-out mice and by competitive blocking in wild-type

81 Recently, we generated Ada3 knock-out mice and demonstrated that deletion of Ada3 le

82 the physiologic/metabolic profile of cavin-1 knock-out mice and determined that they were lean becaus

83 in microtubule assembly and bundling, using knock-out mice and expression of WT and mutant Dcx in no

84 t using either specific inhibitors or PDE10A knock-out mice and has been suggested as a promising tar

85 thionine biosynthesis by constructing LanCL1 knock-out mice and measuring LK concentrations in their

86 ondria of alpha-, beta-, and gamma-synuclein knock-out mice and monomeric alpha-synuclein, this curre

87 t the late stage of membrane fusion in Ophn1 knock-out mice and OPHN1-silenced bovine chromaffin cell

88 ding specificity was assayed in CD-1 and sEH knock-out mice and Papio anubis (baboon) through pretrea

89 Using knock-out mice and primary brain cells, we connect a key

90 ells of Cplx3/4 wild-type and Cplx3/4 double knock-out mice and quantified synaptic vesicle number at

91 -200 was decreased in kidneys from HNF-1beta knock-out mice and renal epithelial cells expressing dom

92 In the present study we generated IP6K3 knock-out mice and show that IP6K3 is highly expressed i

93 nfirm recent data obtained in the hypocretin knock-out mice and suggest that the absence of hypothala

94 ype previously reported in alphaB-crystallin knock-out mice and suggests that the elevated chaperone

95 ct on somatic inhibition was absent in TRPV1 knock-out mice and was also eliminated by two different

96 ssed and compared with responses in p75(NTR) knock-out mice and wild-type animals.

97 of spinal and supraspinal A3AR, lost in A3AR knock-out mice, and independent of opioid and endocannab

98 ralgesia, an effect that was absent in TRPV1 knock-out mice, and was blocked by the TRPV1 antagonist

99 gnificantly down-regulated in NSPCs from APP knock-out mice (APPKO) and increased in APP transgenic (

100 recordings from hippocampal neurons of KCTD knock-out mice are consistent with these findings and in

101 at the phenotypical changes in collagen XIII knock-out mice are milder than symptoms in human patient

102 s, several neurological phenotypes of R7-RGS knock-out mice are not readily explained by dysregulated

103 Furthermore, adipose-specific Dnmt3a knock-out mice are protected from diet-induced insulin r

104 Although separase is essential, securin knock-out mice are surprisingly viable and fertile.

105 ondria of alpha-, beta-, and gamma-synuclein knock-out mice are uncoupled, as characterized by increa

106 Homozygous Mtdh knock-out mice are viable, but males are infertile.

107 nese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biolo

108 d expression of piRNAs in the testes of Mtdh knock-out mice as compared with wild type mice.

109 tein 4 (MRP4)-expressing cell lines and MRP4 knock-out mice as model systems and wound healing assays

110 sosomal glycogen content to the level of GAA knock-out mice, as did a mutant lacking the Atg8 family

111 ogenesis were downregulated in the testes of knock-out mice, as well as Hsd17b3, which encodes a key

112 LTD was absent in CB1 knock-out mice but preserved in heterozygous littermates

113 erations in dendritic spine density in Fbxo2 knock-out mice, but result instead in increased axo-dend

114 In Capn3 knock-out mice (C3KO), Ca(2+) release and Ca(2+)/calmodu

115 Exercise of 3-month-old laforin knock-out mice caused a similar depletion of glycogen bu

116 of RLC phosphorylation in conditional cMLCK knock-out mice caused cardiac dilation and loss of cardi

117 occurs in rod arrestin and rhodopsin kinase knock-out mice, caused a rapid and specific induction of

118 CBE1DeltaCollagen mice fully phenocopy CCBE1 knock-out mice, CCBE1DeltaEGF knock-in embryos still for

119 is enhanced in the muscle and liver of Sco2 knock-out mice, clearly suggesting that cell death is a

120 In GluN3A knock-out mice, cocaine did not alter SK channel functio

121 ST were up to 2.7 times greater in alphaENaC knock-out mice compared with the respective field volume

122 protocol, LID severity was decreased in Narp knock-out mice compared with their wild-type littermates

123 ession and protein levels in bone from Sirt1 knock-out mice compared with wild type mice.

124 ests, glucose disposal was enhanced in SIRT2 knock-out mice, compared with wild type controls, withou

125 In Rarb(-/-) knock-out mice, concomitant reduction of Gad65, dopamine

126 mma-H2AX in spermatocytes of homozygous Mtdh knock-out mice confirms an increase in unrepaired DNA br

127 hibited adipose tissue expansion observed in knock-out mice correlated with lower expression of genes

128 s or a control vector into the CeA of orexin knock-out mice crossed with vGAT-Cre mice, resulting in

129 In Cx26 conditional knock-out mice (Cx26(Sox10-Cre)), the maturation of IHCs

130 t-specific protein-1 driven conditional Cx43 knock-out mice (Cx43fsp1KO).

131 e hypermethylation in the brain, we used Ddo knock-out mice (Ddo(-/-)), which show constitutively sup

132 We showed that myeloid-specific PRMT1 knock-out mice demonstrate higher proinflammatory cytoki

133 e experiments on kisspeptin-specific ERalpha knock-out mice demonstrate that ERalpha in kisspeptin ce

134 Analyses of Tulp1 knock-out mice demonstrate that Tulp1 is essential to ke

135 Selective antagonists and neurons from knock-out mice demonstrated a BLT1-dependent sensitizati

136 -derived macrophages from wild-type and GILZ knock-out mice demonstrated that curcumin inhibits the a

137 ped similarly in wild-type, GluK1, and GluK2 knock-out mice, demonstrating that GluK1 kainate recepto

138 Conditional DCC knock-out mice develop balance and coordination deficits

139 ely 800-1000-fold), indicating that Slc30a10 knock-out mice develop hypothyroidism.

140 uPA-knock-out mice developed fewer and smaller TSC2-null lun

141 demonstrated that knockdown of Stbd1 in GAA knock-out mice did not alter lysosomal glycogen storage

142 The Dlx1/Dlx2 double knock-out mice die at birth with abnormal cortical devel

143 The protein is essential for development as knock-out mice die in utero due to placental defects cau

144 In dectin-1-null mutant (knock-out) mice, dieback of corticospinal tract axons al

145 Ric-8b conditional knock-out mice display impaired olfactory guided behavio

146 use embryonic fibroblasts derived from LRRK2 knock-out mice display increased microtubule acetylation

147 es CerS3 activity, whereas cytosol from ACBP knock-out mice does not.

148 Cys(259) were identical to those of p75(NTR) knock-out mice even though the Cys(259) mutant differed

149 In vivo, EC-specific ATG7 knock-out mice exhibit a basal reduction in endothelial-

150 Pcmt1 knock-out mice exhibit a profound neuropathology and die

151 avioral analyses show that PRMT8 conditional knock-out mice exhibit impaired hippocampal-dependent fe

152 MCT8 knock-out mice exhibit impaired TH levels; however, they

153 hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a comprehensive brake in their

154 OEBFs prepared from OPG-knock-out mice exhibited a similar effect, indicating OP

155 CB1R knock-out mice exhibited no ethanol-induced neurodegener

156 Cell culture and knock-out mice experiments demonstrated that M1 muscarin

157 Pcsk9 knock-out mice expressing a human bacterial artificial c

158 Axons that reach the GP in Frizzled3 knock-out mice fail to enter this structure.

159 ozotocin administration, the retina of REDD1 knock-out mice failed to do so.

160 r, after weaning and compared with controls, knock-out mice failed to gain weight, were smaller, and

161 L-6, IL-1beta, and ccl5 in the skin of IFNAR knock out mice following subcutaneous administration.

162 II expression (732 +/- 162% of normal) in HA knock-out mice following administration of 2 x 10(12) ve

163 (PcTx1) and the absence of these currents in knock-out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest

164 We generated knock-out mice for ELKS1 and found that its constitutive

165 c1, we analyzed bones from OB-specific BMP-2 knock-out mice for NFATc1 expression by immunohistochemi

166 rated inducible and skeletal muscle-specific knock-out mice for Rheb (iRhebKO) and TSC2 (iTSC2KO) and

167 both inducible and skeletal muscle-specific knock-out mice for Rheb and iTSC2KO mice.

168 Unfortunately, the available P2RX7 knock-out mice generated by pharmaceutical companies pos

169 In fasted double knock-out mice, glycogen accumulation in skeletal and ca

170 We used male and female heterozygous Gnal knock-out mice (Gnal(+/-)) to study how GNAL haplodefici

171 Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after bi

172 Similarly, knock-out mice had delayed leptin resistance development

173 lowing AKAP siRNA transfection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685 phosp

174 PTH2R knock-out mice had significantly reduced c-Fos activatio

175 uring the CP, but not the pre-CP or in GAD65 knock-out mice, had larger synapses and increased docked

176 required for endogenous CPC response as Pin1 knock-out mice have a reduced number of proliferating CP

177 regulatory protein that binds Ahi1, and Hap1 knock-out mice have been reported to have JBTS-like phen

178 ndings are complicated by the fact that ApoE knock-out mice have highly elevated plasma lipid levels,

179 VGF knock-out mice have impaired fear and spatial memory.

180 Caspase-3 knock-out mice have increased spine density and altered

181 Although Cdkl5 constitutive knock-out mice have recapitulated key aspects of human s

182 Studies analyzing complete Coronin 1a knock-out mice have shown that this molecule is an impor

183 nducible astrocyte-specific Fmr1 conditional knock-out mice (i-astro-Fmr1-cKO) and restoration mice (

184 n-ligands have largely been identified using knock-out mice, important differences may exist between

185 Using conditional knock-out mice in which Bcl-xL is deleted in neural prog

186 optive CTL transfer from wild-type into Rag1 knock-out mice increased infarct size.

187 In apolipoprotein E knock out mice, increased (18)F-FLT signal was observed

188 r studies performed on P2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are involved in t

189 ts obtained with antagonists and DA receptor knock-out mice indicated that endogenous activity of bot

190 ease was similar in wild-type and kisspeptin knock-out mice indicating that this release is independe

191 er did not increase the infarct size of Rag1 knock-out mice, indicating antigen-dependent activation

192 and by 60% at 13 months as compared with GAA knock-out mice, indicating that the transport of glycoge

193 rferon-gamma knock-out but not from perforin knock-out mice induced neuronal cell death in vitro.

194 from perforin knock-out or interferon-gamma knock-out mice into Rag1 knock-out mice revealed that CT

195 The hypophagic response of Nckx4 knock-out mice is accompanied by hyperactivation of neur

196 Accordingly, the neuroretina of PrP-knock-out mice is iron-deficient.

197 Asc transport across the intestines of SVCT1 knock-out mice is normal indicating that alternative asc

198 s in R1a subunit expression are seen in Fmr1 knock-out mice (KO) mice, a widely used animal model of

199 SMCs derived from LPA receptor 1 (LPA1) knock-out mice lack the ability of Cyr61 induction and c

200 yltransferase (LCAT) and LDL receptor double knock-out mice (Ldlr(-/-)xLcat(-/-) or DKO) spontaneousl

201 combinant TRX in wild-type mice, but not TG2 knock-out mice, led to a rapid rise in intestinal transg

202 In studies with both alpha6 integrin knock-out mice lenses and primary lens cell cultures fol

203 al cerebral ischemia we used TNF conditional knock out mice (LysMcreTNF(fl/fl)) in which the TNF gene

204 ng eosinophil-derived granule protein double knock-out mice (major basic protein-1/eosinophil peroxid

205 In vivo, cerebella in Mef2d knock-out mice manifest increased susceptibility to DNA

206 d adducin whose altered disposition in IP6K3 knock-out mice may mediate phenotypic features of the mu

207 In Frizzled3 knock-out mice, MSN axons fail to extend along the anter

208 20 controls in normal sinus rythm) and nNos-knock-out mice (n=28 compared with 27 wild-type litterma

209 irtually identical to those observed in Wnk1-knock-out mice: no mature large vessels in yolk sacs, de

210 We found that olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf

211 induced in almost all neuron-specific SOCS3 knock-out mice on this diet.

212 toxin receptor signaling were analyzed using knock-out mice or specific inhibitors.

213 Dorsal root ganglia in Zfp36l2 knock-out mice, or wild-type ganglia expressing ZFP36L2

214 ressed with fluorouracil in apolipoprotein E knock out mice (P<0.05).

215 rior low gradient in the striatum, and Wnt5a knock-out mice phenocopy striatal anterior-posterior def

216 cardiac fibroblasts isolated from PI3Kgamma knock-out mice (PI3KgammaKO) showed decreased insulin-st

217 tive deletion of BLA KORs in KOR conditional knock-out mice prevented foot-shock-induced CPP reinstat

218 by using anti-murine Abeta antibodies or APP knock-out mice, prevents the cGMP-dependent enhancement

219 ansgenic mice and undetectable levels in ASM knock-out mice prove that the measured ASM activity orig

220 Adiponectin knock-out mice receiving dextran sulfate sodium exhibite

221 Given that the receptor double knock-out mice resemble reeler mutants, we infer that Re

222 xogenous expression of human Stbd1 in double knock-out mice restored the liver lysosomal glycogen con

223 preoptic nucleus of fever-refractive mPGES-1 knock-out mice, resulted in a temperature elevation in r

224 of the vertebrate P3H family, P3h3 and Sc65 knock-out mice revealed a common lysine under-hydroxylat

225 or interferon-gamma knock-out mice into Rag1 knock-out mice revealed that CTL neurotoxicity was media

226 r earlier findings with retina-specific Rce1 knock-out mice, rod PDE6 in Icmt-deficient mice traffick

227 In NG2 knock-out mice, sensory axons in the dorsal columns dieb

228 Romk knock-out mice show a similar phenotype to Bartter syndr

229 ts showed that the olfactory-specific Ric-8b knock-out mice show an impaired sense of smell, even tho

230 Fltp knock-out mice show BB docking and ciliogenesis defects

231 Furthermore, we report that aged APLP1 knock-out mice show impaired basal transmission and a re

232 miR-155 knock-out mice show reversal of LPS-induced neurogenic d

233 Among other phenotypical differences, knock-out mice showed a significantly impaired glucose t

234 GECs from iPLA2gamma knock-out mice showed blunted ATF6 activation and chaper

235 Castration of conditional Pten knock-out mice showed increased Akt, phosphorylated Akt,

236 holesterol atherogenic diet-challenged Sort1 knock-out mice showed less hepatic free cholesterol accu

237 of cultured neurons from wild-type and SUMO1 knock-out mice showed that anti-SUMO1 immunolabelling at

238 sma analyses of single-proprotein convertase-knock-out mice showed that loss of the convertase furin

239 was observed in Neto1, but not Neto2, single knock-out mice, specifically implicating Neto1 in regula

240 sensitivity was not evident in delta-subunit knock-out mice subjected to a similar withdrawal paradig

241 mbryonic, postnatal, and adult brain of Fmr1 knock-out mice suggest an important role for tPA in the

242 yte-specific furin, PC5/6, or complete PACE4 knock-out mice suggested that the cleavage of overexpres

243 ype mice, the depression was slower in cpg15 knock-out mice, suggesting impairment in short-term depr

244 aptophysin expression were abolished in Apoe-knock-out mice, suggesting the importance of daidzein-in

245 ecificity in this adaptive plasticity in OMP knock-out mice suggests a potential role for this protei

246 We used novel trypsinogen-7 knock-out mice (T(-/-)), which lack intra-acinar trypsin

247 ound a lower generation of DYT1 knock-in/p58 knock-out mice than expected from this cross, suggesting

248 not gain rate, remains higher in adult Lynx1 knock-out mice than in control wild-type mice, revealing

249 Furthermore, knock-out mice that lack PLK2 (the predominant kinase th

250 Generation of knock-out mice that lacked PEMT showed that they were pr

251 amined Leydig cell-specific TSPO conditional knock-out mice that suggested TSPO was not required for

252 In beta2-microglobulin knock out mice, the D76N beta2-microglobulin/ Nb24 pre-f

253 rrel cortex activity in young and adult Fmr1 knock-out mice, the mouse model of fragile X syndrome (F

254 In Exoc5 photoreceptor-specific knock-out mice, the photoreceptor outer segment structur

255 Taking advantage of the conditional Oxtr knock-out mice, the present study highlights the importa

256 generated ERK1 and conditional ERK2 compound knock-out mice to determine the role of ERK signaling du

257 We then use conditional knock-out mice to eliminate FMRP only in the PFC alone o

258 We used neuron-specific SOCS3 knock-out mice to elucidate this and the effects on regi

259 exposed to O3 Additionally, exposure of LXR knock-out mice to O3 enhanced pro-inflammatory cytokine

260 logical roles of the PRLs, we generated PRL2 knock-out mice to study the effects of PRL deletion in a

261 d potent inhibitors of PI4KA and conditional knock-out mice to study the importance of this enzyme in

262 fied mice (germline Npy, Y1, and Y2 receptor knock-out mice) to assess pulsatile GH secretion under b

263 We then used VU0238429, along with M5 knock-out mice, to elucidate the role of this receptor i

264 In contrast to the knock-out mice, transgenic mice overexpressing a human m

265 reducing lysosomal storage in the CNS of ASA-knock-out mice treated by ERT.

266 indled wild-type mice, but not delta-subunit knock-out mice, undergoing NSW-induced seizures, confirm

267 ssion, but prior microarray studies in Mecp2 knock-out mice using brain tissue homogenates have revea

268 Here, we produced Dgcr8 conditional knock-out mice using progesterone receptor (PR)-Cre (Dgc

269 itotic forebrain-specific Cited2 conditional knock-out mice, using the Emx1-Cre and NEX-Cre mouse lin

270 uncover these mechanisms, we generated Mtdh knock-out mice via a targeted disruption of exon 3.

271 Paradoxically, excitability in kisspeptin knock-out mice was similar to the maximum observed in co

272 hippocampal cultures from Arp2/3 conditional knock-out mice, we analyze the roles of the Arp2/3 compl

273 Here, through the use of conditional knock-out mice, we demonstrate a requirement for ILK in

274 as wild-type and dopamine transporter (DAT) knock-out mice, we demonstrate that dopamine uptake thro

275 rocessing in cellular models and in specific knock-out mice, we demonstrate that the membrane-bound s

276 Using transfected cells and knock-out mice, we demonstrated that R7-binding protein

277 Furthermore, using knock-out mice, we determined that the zeta isoform of D

278 Using conditional Gdnf knock-out mice, we found that endogenous GDNF affects st

279 ased models and F-box Only Protein 2 (Fbxo2) knock-out mice, we found that the ubiquitin ligase subst

280 NS-1 beta-cells and beta-cell-specific Txnip knock-out mice, we now found that TXNIP regulates IAPP e

281 e and antagonist telenzepine, as well as M1R knock-out mice, we show here that M1R, along with beta2-

282 Here, using conditional knock-out mice, we show that hippocampal-dependent learn

283 Using connexin knock-out mice, we show that IHCs fire spontaneous actio

284 ing pharmacological tools and beta-arrestin2 knock-out mice, we show that KOR-mediated ERK1/2 phospho

285 Using muscle-specific PGC-1alpha knock-out mice, we show that PGC-1alpha is necessary for

286 nforced by an early report that claimed TSPO knock-out mice were embryonic lethal.

287 n 1a Furthermore, T cell-specific Coronin 1a knock-out mice were largely resistant to the induction o

288 Adiponectin knock-out mice were orally administered dextran sulfate

289 ected, male and female neuron-specific SOCS3 knock-out mice were protected from HCD-induced obesity.

290 The knock-out mice were resistant to diet-induced obesity an

291 Consistent with these results, DRD4 knock-out mice, when compared with wild-type and heteroz

292 stin expression through use of the SOST gene knock-out mice, which are resistant to Pb-induced trabec

293 f water and electrolytes was higher in VAMP3 knock-out mice, which produced more diluted urine.

294 Here, we subjected knock-out mice, which suffer from impaired intrinsic pla

295 t, will become a bilateral movement in EphA4 knock-out mice with a bilateral CST.

296 Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperar

297 Knock-out mice without functional mGluR5 exhibit severe

298 in prion diseases, we tested whether mGlur5 knock-out mice would be susceptible to prion infection.

299 from both wild type (WT) and Bax/Bak double knock-out mice (WT MEF and DKO MEF that were responsive

300 in both constitutive and conditional PKMzeta knock-out mice, yet both are still impaired by ZIP appli