ライフサイエンスコーパス: knockout

1 BL1 showed an effect similar to that of HBL1 knockout.

2 e frameshift phenotypes were consistent with knockout.

3 activated receptor alpha (Ppara(-/-)) double knockout 129/SvJ mice for 12 weeks from weaning.

4 hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq(-/-) ) and wild-type (WT) mice were cro

5 amylin in the pancreas (HIP rats) and amylin knockout (AKO) rats intravenously infused with aggregate

6 ases) or gene replacement (e.g., conditional knockout alleles containing exons flanked by LoxP sites)

7 Surprisingly, Slc30a10 knockouts also had elevated thyroid manganese and develo

8 A knockout, an antagonist, or a local silencing of MKP-1 a

9 y human CD4(+) T cells through Cas9-mediated knockout and antibody blockade.

10 utero valproic acid (VPA) exposure, CNTNAP2 knockout and FMR1 knockout-layer 5 subcortically project

11 y site-directed mutagenesis and use of STAT3 knockout and mitochondria-depleted cells.

12 protein-tyrosine phosphatases Shp1 and Shp2, knockout and transgenic mouse models have revealed disti

13 No differences were observed between GPR55 knockout and wild type mice in either development or mai

14 binding experiments in Wistar and in mGluR2 knockout and wildtype rats as well as in vivo biodistrib

15 We recruited these human knockouts and challenged them with an oral fat load.

16 Using data from five single gene knockouts and the wild type strain, we decrease the mean

17 comprehensive panel of kinases/phosphatases knockouts and time-resolved perturbations to the nitroge

18 In the present study, Calhm1 knockout, Panx1 knockout, and wild-type mouse nasal septal epithelial ce

19 scoliosis phenotype, among ciliopathies and knockout animal models, we expected IS patients to have

20 Furthermore, the homozygous-knockout animals have reduced adult intestinal epithelia

21 nd their substantial reduction in melanopsin knockout animals indicate a contribution from inner reti

22 sible for the decreased proliferation in the knockout animals.

23 ) knock-in mice were bred onto il17a and Tnf knockout backgrounds allowing for constitutive Nlrp3 act

24 of PHD2-deficient RAW cells and primary PHD2 knockout bone marrow-derived macrophages (BMDM).

25 ed breast cancer cells in wild-type and RAGE-knockout C57BL6 mice.

26 Asian GWAS; in contrast BVES and CAP2 murine knockouts caused cardiac conduction defects.

27 We show that Cav1-knockout CD8 T cells have a reduction in membrane choles

28 hality, whereas conditional Ssb1/Ssb2 double knockout (cDKO) in adult mice resulted in acute lethalit

29 that Pak1 overexpression, knockdown and Pak1 knockout cell line models showed that Pak1 confers prote

30 ase activity in a minigenome assay and TRIM6 knockout cells have reduced replication of infectious EB

31 Triple knockout cells still contain near-normal F-actin levels.

32 In micro1 knockout cells, intracellular CCVs still form, but acidi

33 ted with activation of ERK2 were seen in PKA knockout cells.

34 In DDX4 knockout chickens, PGCs are initially formed but are los

35 midbrain DA neurons of DAT-Cnr2 conditional knockout (cKO) mice.

36 ive (resulting from FoxN1-floxed conditional knockout [cKO]) and naturally aged mouse models.

37 We used Cln3 knockout (Cln3(Deltaex1-6)) mice and found increased anx

38 Apical ATP release was attenuated in Calhm1 knockout cultures following mechanical stimulation at a

39 Exogenous application of S100A8 to S100A9 knockout CVB3 mice induced a severe myocarditis similar

40 pregnant WT mice but not in pregnant B-cell knockout dams, and antigen concentrations in WT amniotic

41 DAT-Knockout (DAT-KO) mouse is currently the best animal mod

42 THIK-1 function pharmacologically or by gene knockout depolarizes microglia, which decreases microgli

43 lomerase-positive cells and their human TERC knockout-derived ALT human cell lines, we show that ALT

44 Constitutive Ssb1/Ssb2 double knockout (DKO) caused early embryonic lethality, whereas

45 Feeding Gsta4(-/-)/Ppara(-/-) double-knockout (dKO) mice liquid diets containing corn oil res

46 d dysregulation of imprinted genes in Naa10p-knockout embryos and embryonic stem cells.

47 Lbh knockout exacerbated disease severity, which is associat

48 strategy to select against re-targeting the 'knockout-first' allele and identify essential genes in E

49 Female UTX NC knockout (FKO) demonstrates enhanced phenotypic severity

50 We find that MFN2 knockout from MCF7 and A549 cells via Crispr/Cas9 greatl

51 Combined maternal and zygotic knockout further revealed Aire's critical functions for

52 AF, MEK, and AKT; HUH7 cells with MAN2A1-FER knockout had significant decreases in phosphorylation of

53 In contrast, Slc30a10 single knockouts had elevated manganese levels in the liver as

54 Slc39a14 single and Slc30a10/Slc39a14 double knockouts had higher manganese levels in the blood and b

55 Furthermore, Sesn2-knockout hearts demonstrate a cardiac phenotype and resp

56 Cell proliferation was examined in ITPR2-knockout HepG2 cells generated by the CRISPR/Cas9 system

57 ITSN-deficient mice (knockout/heterozygous and knockdown) were subjected to t

58 r of I-A(12%) CD25(-)CD4(+) T cells into RAG-knockout hosts revealed increased autoaggression activit

59 nfection in type I interferon receptor IFNAR knockout (Ifnar1 (-/-) ) mice, an infection model that e

60 ubjected to IL-17A neutralization and IL-17A knockout (il17a(-/-) ) mice were protected against bleom

61 ten requires Cas9 to elicit efficient target knockout in a population of cells.

62 periments of Ras overexpression and catalase knockout in conjunction with the literature.

63 Ascl2 knockout in embryonic myoblasts decreases both the numbe

64 RhoA knockout in fibroblasts induced vimentin intermediate fi

65 Furthermore, Gab2 knockout in HepG2 cells restrained cell proliferation, m

66 ted using inducible, adipocyte-specific Cx43 knockout in mice (Gja1 (adipoq) KO) and by overexpressio

67 We found that Gnb5 knockout in mice or in the insulin-secreting MIN6 cell l

68 By using targeted knockout in olfactory epithelial stem cells in adult mic

69 he effects of different combinations of gene knockout, including arsenate reductase (HAC1), gamma-glu

70 ing adaptive laboratory evolution (ALE), the knockouts increase their growth rate by up to 3.6-fold.

71 in Apj mutants, which was also seen in Ccbe1 knockouts, indicating that the endocardium is activated

72 e therefore investigated whether Tric-a gene knockout (KO) alters the single-channel function of skel

73 locking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was

74 on either a human ApoE knock-in (KI) or ApoE knockout (KO) background, here we show that P301S/E4 mic

75 prepared heparan sulfate proteoglycan (HSPG)-knockout (KO) cells by using a clustered regularly inter

76 abolished in TRAF6/Pellino1/Pellino2 triple-knockout (KO) cells, but not in TRAF6 KO or Pellino1/2 d

77 Human kidney cells with Polbeta knockout (KO) had higher endogenous mitochondrial DNA (m

78 In the present study, we found that ALCAM knockout (KO) mice developed a more severe myelin oligod

79 type (WT) control and nonhematopoietic DREAM knockout (KO) mice, DREAM KO control and hematopoietic D

80 ot observed in the inflamed colons of AKAP12 knockout (KO) mice.

81 86+) and cytotoxic T cells (CD8+) in the p65 knockout (KO) mice.

82 ynic efficacy of LY2828360 was absent in CB2 knockout (KO) mice.

83 A conditional betaENaC MG knockout (KO) mouse model was generated to elucidate the

84 atrial-specific Na(+) /Ca(2+) exchange (NCX) knockout (KO) mouse, a model of cellular Ca(2+) overload

85 CD163 knockout (KO) pigs are resistant to infection with genot

86 Several immune responses are normal in Kv1.3 knockout (KO) rats, suggesting that KCa3.1 can compensat

87 e function of CLEC-2 in vivo have focused on knockout (KO) studies in which both the receptor and its

88 NADPH oxidase-deficient (gp91(phox) knockout [KO]), iNOS-deficient (iNOS KO), and C57BL/6 wi

89 In PDC "knockout" (KO) animals, the long-term regenerative poten

90 ation of protein levels for otherwise lethal knockouts (KOs).

91 We showed previously that conditional La knockout (La cKO) from mouse cortex neurons results in d

92 id (VPA) exposure, CNTNAP2 knockout and FMR1 knockout-layer 5 subcortically projecting (SC) neurons c

93 tegy to generate high-complexity pooled dual-knockout libraries to identify synthetic lethal and buff

94 e and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and foun

95 and protein were similar in MSK1/2 and DUSP1 knockout macrophages.

96 Homozygous tau knockout (Mapt(-/-)) mice develop age-dependent dopamine

97 serum from methionine adenosyltransferase 1a knockout (MAT1A-KO) mice, which have chronically low lev

98 y, we addressed the possibility that Gsalpha knockout may result in impaired VEGF production.

99 fibrosis in the multidrug resistance gene 2-knockout (Mdr2(-/-)) mouse model of PSC.

100 ine this possibility, beta-cell specific TFG knockout mice (betaTFG KO) were generated.

101 ype (WT) and liver-specific Foxo1/3/4 triple knockout mice (LTKO).

102 s of in vitro-polarized TH2 cells from Spi2A knockout mice (P < .005) and in vivo after ovalbumin cha

103 Panx1 knockout mice (Panx1(-/-)) were protected from hypersens

104 Reducing levels of TNFalpha in PGRN knockout mice abolished excessive self-grooming and the

105 wild-type and various inflammasome component knockout mice also revealed the process of asbestos-indu

106 sis in culture and in vivo Using conditional knockout mice and derived white and brown preadipocytes,

107 e conducted in xeroderma pigmentosum group A knockout mice and diethylnitrosamine-injected mice, both

108 models of podocyte damage (WT1 heterozygous knockout mice and puromycin aminonucleoside-treated rats

109 e liver DNA of xeroderma pigmentosum group A knockout mice and remarkably reduced HCC incidence in th

110 METHODS AND We used H- and K-Ras gene knockout mice and subjected them to pressure overload to

111 ed in hepatocytes from GCN5L1 liver specific knockout mice and their upstream regulator, FoxO1 protei

112 Interestingly, liver specific Ant2 knockout mice are leaner and resistant to hepatic steato

113 Inhibition of calpain using calpain knockout mice attenuated airway smooth muscle remodellin

114 s were reconstituted in T-cell receptor beta knockout mice by adoptive transfer, and bone turnover, b

115 However, only double-knockout mice continued to exhibit low liver Hamp at 8 w

116 We also show that Zfp106 knockout mice develop severe motor neuron degeneration,

117 In addition, Wap-Int3/P50 knockout mice did not develop mammary tumors.

118 s effect was replicated in vivo, where Ifit2 knockout mice displayed a dramatically more severe disea

119 ke receptor 7 agonist imquimod (IMQ), Trim32 knockout mice displayed compromised psoriasiform phenoty

120 lls, and wounds of epidermis-specific alpha9 knockout mice displayed delayed vascular normalization a

121 Indeed, compared with wild-type mice, MLKL knockout mice displayed more severe AKI.

122 calmodulin-dependent protein kinase II gamma knockout mice displayed reduced CAC.

123 rast, the kidneys of IL-36 receptor (IL-36R) knockout mice exhibit attenuated TILs after UUO.

124 midal neurons from the hippocampus of Celsr3 knockout mice exhibit loss of approximately 50% of gluta

125 ed gene expression, whereas Tsc1 conditional knockout mice exhibited changes in genes regulating TGF-

126 mdx-knockout mice exhibited lower muscle force/endurance as

127 s hepatocyte and macrophage Bmp6 conditional knockout mice exhibited no iron phenotype.

128 Unexpectedly, Syn-2 knockout mice exhibited paradoxical superior glucose hom

129 ore, SSRIs protected both wild-type and SERT knockout mice from behavioral despair induced by chronic

130 Hlx heterozygous knockout mice have defects in brown-like adipocyte forma

131 whereas intestine-specific Sirt1 homozygous knockout mice have reduced development of colon cancer.

132 TRPV1 knockout mice have reduced glutamatergic innervation of

133 IL-12p35, IL-23p19, and IL-12/IL-23p40 knockout mice on a C3H/HeN background, subjected to a me

134 broblasts from dynamin1 like (DNM1L) protein-knockout mice or their WT littermates.

135 type platelets into platelet-specific CLEC-2 knockout mice restored thrombosis.

136 Experiments in knockout mice revealed a major role for TLR2, a lesser r

137 with Apoe(-/-) controls, EphA2(-/-)Apoe(-/-) knockout mice show diminished atherosclerotic plaque for

138 Selenbp1-knockout mice showed biochemical characteristics similar

139 Raptor conditional knockout mice showed decreased extracellular matrix (ECM

140 Compared with control littermates, knockout mice showed impaired glucose tolerance and circ

141 Relative to wild-type littermates, knockout mice showed no gross pathologies.

142 CRTC2 knockout mice that express one CRTC3 allele (CRTC2/3m mi

143 rapid lymphoma development in Id2/Id3 double-knockout mice that is caused by unchecked expansion of i

144 e also generated apoE(-/-)/As3mt(-/-) double knockout mice to test whether As3MT-mediated biotransfor

145 e-selective allosteric modulators along with knockout mice we now report that the effects of mGlu2/3

146 s, hyperglycemic TSP-1(-/-)/ApoE(-/-) double knockout mice were compared with age-matched hyperglycem

147 y potassium loading and restriction, KS-WNK1 knockout mice were deficient in these structures under i

148 Wild type and FcRn knockout mice were injected once with either infliximab

149 Global HCN1 knockout mice were less successful and exhibited atypica

150 Thus, tau- and amyloid protein precursor-knockout mice were protected against lithium-induced iro

151 T-cell subsets in T-cell receptor beta knockout mice were reconstituted by adoptive transfer wi

152 Wild-type and cathepsin K knockout mice were rendered diabetic by streptozotocin (

153 IRF1-knockout mice were resistant to ConA-induced liver damag

154 n, surgical transplant and novel conditional knockout mice were super-ovulated and analyzed.

155 HAT-L4 knockout mice were viable and fertile.

156 prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead i

157 culture or in vivo after challenge of Spi2A knockout mice with ovalbumin in alum.

158 Heterozygous Jagged1 knockout mice, a model for Alagille Syndrome (AGS), also

159 X receptor; Small Heterodimer Partner double knockout mice, a model for bile acid overload, display c

160 as assessed in conscious TRPC6 wild type and knockout mice, and in anesthetized rats with and without

161 In the MC-specific Nrp2 knockout mice, circuit formation of Nrp2(+) MCs and odou

162 In knockout mice, clearance mechanisms are identified for n

163 In double-knockout mice, constitutive phosphorylation of EIF2A and

164 h were not impaired in muscle-specific GLUT4 knockout mice, demonstrating that GLUT4 is not necessary

165 in humans and developmental defects in Abl1 knockout mice, suggest that ABL1 has an important role d

166 osite approach and crossed mdx mice with ApN knockout mice, to obtain mdx mice with ApN depletion.

167 Using conditional knockout mice, we examined the electrophysiological, bio

168 In SPARC knockout mice, we performed an injury study to investiga

169 the hemochromatosis phenotype of global Bmp6 knockout mice, whereas hepatocyte and macrophage Bmp6 co

170 Interleukin-1 receptor type I knockout mice, which display braked immune response and

171 ression, as did podocyte-specific PPAR-gamma knockout mice, which were more sensitive to adriamycin a

172 on, but also in WSX-1/tristetraprolin double knockout mice, with substantial reduction in the number

173 nerated forebrain-specific Foxp1 conditional knockout mice.

174 bone marrow-derived macrophages (BMDMs) from knockout mice.

175 nt of fibrotic phenotype in conditional Vhlh knockout mice.

176 m were partially maintained in microRNA-146a knockout mice.

177 ot found in AMPKalpha1alpha2 muscle-specific knockout mice.

178 ne loss in hippocampal CA1 neurons in Grasp1 knockout mice.

179 blood vessels in wild type but not in TRPV4 knockout mice.

180 transition and its amelioration in caspase-1 knockout mice.

181 sis, which were mitigated in the cathepsin K knockout mice.

182 corrects dendritic spine abnormality in Fmr1 knockout mice.

183 ic responses were abrogated in cyclophilin D-knockout mice.

184 ercome the loss of K(ATP) channels in K(ATP) knockout mice.

185 Thus, we used Ucp2 knockout mice.

186 port of conjugated bile acid species in OATP knockout mice.

187 n-specific Bcl7a and Bcl7b single and double knockout mice.

188 e, an adoptive cell transfer model, and gene knockout mice.

189 egation and secretion are increased in TRAF3 knockout mice.

190 by anti-IL-33 treatment and in TSLP receptor-knockout mice.

191 mice; these effects were eliminated in Taar1 knockout mice.

192 NAc conjugated and unconjugated ASOs in ASGR knockout mice.

193 ression in airway epithelial cells of Ormdl3 knockout mice.

194 the observed heart dysfunction in the double knockout mice.

195 surface levels on CD4(+) T cells of EHD1/3/4 knockout mice.

196 ulated in mouse hepatocyte nuclear factor 4A knockout mice; were early-stage tumors by Barcelona Clin

197 MiR-211 knockout (-/-) mice exhibited a progressive cone dystrop

198 We used a myeloid-specific Mll1 knockout (Mll1(f/f)Lyz2(Cre+) ) to determine the functio

199 Altogether, the conditional Drd2 knockout model studied here revealed the overall fundame

200 expected from the previously reported single knockout models of Ssb1 or Ssb2 Mechanistically, cDKO HS

201 We generated an M-opsin knockout mouse (Opn1mw (-/-)) expressing only S-opsin as

202 ed in monocytes from WAS patients and in WAS-knockout mouse dendritic cells.

203 uced into otherwise microRNA-deficient Dgcr8 knockout mouse embryonic stem cells.

204 In VDR knockout mouse epithelial cells (KO), 1,25(OH)2D3 increa

205 Conversely, Snrk knockout mouse hearts have increased glucose and palmita

206 present evidence, in two different CK2alpha knockout mouse lines, that this regulation is region-spe

207 SUMOylation-deficient-Sf1(2KR/2KR) and Dax1 knockout mouse lines, with FAdE expression/activity reta

208 iction in an angiotensin-converting enzyme 2 knockout mouse model characterized by placental hypoxia.

209 iorate disease pathology in a laminin-alpha2 knockout mouse model of muscular dystrophy, acting as a

210 nd skeletal anomalies in a heterozygous Bmp2-knockout mouse model, suggesting that haploinsufficiency

211 We have developed a double knockout mouse model, which also shows reduced muscle st

212 by utilizing a photoreceptor-specific, PKM2 knockout mouse model.

213 Furthermore, neonatal and interferon gamma knockout mouse models of C. parvum infection identified

214 Interrogation of knockout mouse phenotype resources provides a further av

215 EAF2 knockout mouse prostate was also sensitized to gamma-irr

216 Using two conditional knockout mouse strains and derived cells, we demonstrate

217 scriptomes and targeted metabolomics of five knockout mouse strains deficient in essential factors re

218 Although FOXC1 knockout mouse studies showed that it is not required fo

219 In contrast to the reported phenotype of the knockout mouse, which was developed on a primarily C57BL

220 A mot1.3-1 knockout mutant showed impaired growth concomitant with

221 nsitive phenotype of the Arabidopsis mtp11-3 knockout mutant.

222 e role of LjNPF8.6 on nodule functioning, as knockout mutants display N-fixation deficiency (25%) and

223 AOX1D expression is increased in aox1a knockout mutants from Arabidopsis (especially after rest

224 CML38-knockout mutants generated via T-DNA insertion were inse

225 Knockout mutants of genes for protease subunits are of l

226 Here, we identify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA t

227 , mimicking differentiation defects of Mcph1-knockout neuroprogenitors.

228 Wild-type and Nlrp3 knockout (Nlrp3(-/-)) mice were fed 3,5-diethoxycarbonyl

229 lem, we generated myeloid cell-specific Nrp1-knockout (Nrp1(myel-KO)) mice and applied 2 stringent an

230 he use of this powerful new tool in targeted knockout of a gene residing in the cotton genome.

231 Knockout of AE3 in mice lowers the threshold for trigger

232 Knockout of beta-arrestin-2 (betaarr-2(-/-)) attenuates

233 Germline knockout of both paralogs in mice results in early embry

234 Crispr/Cas9-mediated knockout of caspase b, which acts by proteolytic process

235 Some mice with intestine-specific knockout of FXR were given daily injections of fibroblas

236 Here we show that genetic knockout of Gsto1 alters the response of mice to three d

237 ion of HBL1 repressed, whereas knockdown and knockout of HBL1 increased, cardiomyocyte differentiatio

238 Knockout of HIG2 enhanced LD breakdown and fatty acid (F

239 highly efficient isolation of Cas9-mediated knockout of HPRT, with zero transposon integrations in H

240 Surprisingly, mice with germline knockout of Lgr6 are predisposed to SCC development, thr

241 The conditional knockout of MYPT1 or the knock-in mutation T853A in mice

242 rbour loci (Rosa26 and AAVS1); (2) biallelic knockout of neurodevelopmental transcription factor gene

243 Genetic knockout of NRF2 demonstrates its role in developmentall

244 minals was sharply reduced upon postsynaptic knockout of OGT.

245 Mechanistically, global knockout of PLD4 modulated innate and adaptive immune re

246 We further showed that knockout of RCN2 inhibited EGFR phosphorylation, Ki-67 e

247 In contrast, mice with LPC-specific knockout of Ripk1 showed reduced diethylnitrosamine-indu

248 In vivo, mice with knockout of SREBP2 in astrocytes have impaired brain dev

249 Fibroblast-specific knockout of STAT3, or its pharmacological inhibition, am

250 lta TCR used in conjunction with CRISPR/Cas9 knockout of the endogenous alphabeta TCR resulted in mor

251 However, there has been no evidence that knockout of the gene encoding PLCzeta abolishes the abil

252 the G-protein subunit Gbeta5, such that the knockout of the Gnb5 gene results in degradation of all

253 ow that mice with an adipose-tissue-specific knockout of the microRNA (miRNA)-processing enzyme Dicer

254 Knockout of the OGT gene decreased the synaptic expressi

255 CRISPR/CAS9 knockout of YAP in hESCs enables Activin to induce Wnt3

256 Pancreas-specific knockout of Yap or antibody-mediated depletion of MDSCs

257 were performed on 10 adaptively evolved pgi knockouts of Escherichia coliPgi catalyzes the first rea

258 quantify this back-flux in single and double knockouts of genes relating to PEP synthetase and PTS co

259 Endothelial-specific knockouts of Orai1 and Klf2 also markedly impaired lymph

260 MBS85, resulting in minimal effects of MYPT1 knockout on contraction.

261 Liver-specific knockout or adenovirus-mediated overexpression of DsbA-L

262 s, has been limited by lack of a robust gene knockout or knock-down technology.

263 using targeted genome manipulations such as knockouts or transgenics.

264 In the present study, Calhm1 knockout, Panx1 knockout, and wild-type mouse nasal sept

265 is effect was not seen in PKR-like ER kinase knockout (PERK-KO) or phosphodeficient eukaryotic transl

266 Pan-endothelial- and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defe

267 Yet, when exposed to LPS, GR knockout podocytes demonstrated fewer stress fibers and

268 observations provide a roadmap for a 'human knockout project', a systematic effort to understand the

269 ade leading to multipolar divisions, and its knockout promotes clustering and survival of cells with

270 Uremic wild-type (KL(fl/fl) ) and knockout (Prx1-Cre;KL(fl/fl) ) mice both responded with

271 we demonstrate that Rab27a and Rab27b double-knockout (Rab27DKO) mice that are deficient in exosome s

272 ce, and recombination-activating gene (Rag2) knockout (Rag2(-/-)) mice by means of repeated intratrac

273 n PET imaging studies in wildtype and mGluR2 knockout rats in a primate and in humans were performed.

274 The phenotype of SERT knockout rats was a summation of the phenotypes generate

275 ing reverse genetics, we generated a ToV-PLP knockout recombinant virus.

276 In 3D collagen matrix, RhoA knockout reduced fibroblast branching and meshwork forma

277 ibody or tumor necrosis factor receptor gene knockout, reduced inflammation and retinal ganglion cell

278 his composition and demonstrated that Tnni3k knockout resulted in elevated MNDCM content and increase

279 nt with poor feto-placental perfusion, Egfl7 knockout resulted in reduced placental weight and fetal

280 es of the Brn3b single- and Dlx1/Dlx2 double-knockout retinas, including near total RGC loss with a m

281 Heterozygous Scn1a knockout (Scn1a (+/-)) mice recapitulate the severe epil

282 Oocyte-specific Gdf9-iCre conditional knockout (Setd1b(Gdf9) cKO) ovaries develop through all

283 s attenuated in ATII cell-specific HIF1alpha knockout (SftpcCreERT2(+/-);HIF1alpha(f/f)) mice.

284 er with data showing that functional protein knockout shifts splicing toward the fully spliced isofor

285 Pdcd4 knockdown/knockout significantly increased the translation of 5'Si

286 l of T2DM: lipodystrophic Bscl2(-/-) (seipin knockout [SKO]) mice.

287 ron labeling from the inducible Cre-mediated knockout (SLICK) mice.

288 ic backgrounds (e.g. wild-type strain versus knockout strain).

289 rious alternative to wild-type Cas9 for gene-knockout studies.

290 se model of PSC (multidrug resistance gene 2 knockout), the hepatic knockdown of GnRH decreased IBDM

291 J wild-type mice, Toll-like receptor (TLR) 4 knockout (Tlr4(-/-)) mice, and recombination-activating

292 lower, in wild-type DCs (wtDCs) than in TNF knockout (TNFko) DCs.

293 34, a PARP inhibitor, and abolished by TRPM2 knockout (TRPM2-KO).

294 A BSG knockout was completely refractory to parasite invasion

295 The Deltaarg knockout was incapable of growth in the absence of polya

296 athyroid thyroxine levels of Slc30a10 single knockouts were lower than those of controls.

297 ing protein-1) floxed mice (XBP1-conditional knockout), with antibody-mediated depletion of CD4+ T ce

298 Therefore, We hypothesized that a Spag6 knockout would affect the development and function of SG

299 address this question, heterozygous ERalpha knockout (WT/KO) dams were fed a control breeder chow di

300 primary cardiomyocytes derived from XLalphas knockout (XLKO) pups showed enhanced transferrin interna