ライフサイエンスコーパス: knockout mice

1 impact immunoglobulin class switching in DEK knockout mice.

2 SAM vaccines were evaluated in IFN receptor knockout mice.

3 double-knockout mice lived longer than Pkd1-knockout mice.

4 in either HSP70-1 siRNA in vitro or HSP70-1 knockout mice.

5 lunted in PDE4D but not in wildtype or PDE4B knockout mice.

6 count for the attenuated phenotype in double knockout mice.

7 NAc conjugated and unconjugated ASOs in ASGR knockout mice.

8 es with C57Bl6-J (control) and interleukin 6-knockout mice.

9 Similar efficacy was observed in Kv3.2 knockout mice.

10 controls GLP-1 production, was decreased in knockout mice.

11 egulatory T cell-to-leukocyte ratio in RIPK3 knockout mice.

12 ression in airway epithelial cells of Ormdl3 knockout mice.

13 and GABA) in the auditory brainstem of Fmr1 knockout mice.

14 nce in glucose tolerance between control and knockout mice.

15 revention is largely lost in alpha-gustducin-knockout mice.

16 graft-versus-host disease in female ERalpha-knockout mice.

17 response to VPA, but not NK cells from STAT3 knockout mice.

18 germline mutations, we generated conditional-knockout mice.

19 eral obstruction injury was induced in Snai1 knockout mice.

20 del was significantly shortened in the TRAF3 knockout mice.

21 mice compared with WT and RPE65 heterozygous knockout mice.

22 s of mouse embryo fibroblast cells from Wwox-knockout mice.

23 C57Bl6 and glutathione peroxidase 1 knockout mice.

24 3 days; hgd40 reduced colitis in TNFR double-knockout mice.

25 p-tau in the contralateral CA1 area in A2AR knockout mice.

26 e in arteries using genetic rescue in Notch3 knockout mice.

27 loss-of-function by crossing them with PD-1 knockout mice.

28 d therefore generated Dlx1/Dlx2/Brn3b triple-knockout mice.

29 and die around E10.5, which phenocopies Mll4 knockout mice.

30 effects of Meto in MI wild-type and beta3AR knockout mice.

31 D6 function in alternative splicing in jmjd6 knockout mice.

32 the observed heart dysfunction in the double knockout mice.

33 a skin tumor cell line derived from EphA1/A2 knockout mice.

34 ry hyperparathyroidism in 1alpha-hydroxylase knockout mice.

35 ene specifically in the intestine, and ABCG8-knockout mice.

36 em cells of wild-type mice but not in STAT5a knockout mice.

37 on potential firing of IO neurons in TMEM16B knockout mice.

38 orally to wild-type (WT) and Abcb1a/b;Abcg2 knockout mice.

39 nuates the behavioural abnormalities in Fmr1 knockout mice.

40 surface levels on CD4(+) T cells of EHD1/3/4 knockout mice.

41 ted in delayed and reduced papillomatosis in knockout mice.

42 These plastic changes were impaired in MMP-9 knockout mice.

43 and atherosclerosis in hyperlipidemic Mir155 knockout mice.

44 FcgammaRs in MCMV-infected Fcer1g and FcgR2b knockout mice.

45 rinsic excitability of DG neurons in AdipoR2 knockout mice.

46 ulin secretion was not affected in islets of knockout mice.

47 in manganese were recently recapitulated in knockout mice.

48 pha1B knockin reporters, and beta1 and beta2 knockout mice.

49 d-type but not in cardiac myocytes from ATF6 knockout mice.

50 nerated forebrain-specific Foxp1 conditional knockout mice.

51 bone marrow-derived macrophages (BMDMs) from knockout mice.

52 nt of fibrotic phenotype in conditional Vhlh knockout mice.

53 m were partially maintained in microRNA-146a knockout mice.

54 ot found in AMPKalpha1alpha2 muscle-specific knockout mice.

55 ne loss in hippocampal CA1 neurons in Grasp1 knockout mice.

56 mice; these effects were eliminated in Taar1 knockout mice.

57 blood vessels in wild type but not in TRPV4 knockout mice.

58 transition and its amelioration in caspase-1 knockout mice.

59 sis, which were mitigated in the cathepsin K knockout mice.

60 corrects dendritic spine abnormality in Fmr1 knockout mice.

61 ic responses were abrogated in cyclophilin D-knockout mice.

62 ercome the loss of K(ATP) channels in K(ATP) knockout mice.

63 Thus, we used Ucp2 knockout mice.

64 port of conjugated bile acid species in OATP knockout mice.

65 n-specific Bcl7a and Bcl7b single and double knockout mice.

66 e, an adoptive cell transfer model, and gene knockout mice.

67 egation and secretion are increased in TRAF3 knockout mice.

68 by anti-IL-33 treatment and in TSLP receptor-knockout mice.

69 of (1) wild-type mice, (2) arrhythmic Arntl knockout mice, (3) mice fed at regular intervals during

70 Still, in knockout mice a significant thickening of the epidermis

71 Heterozygous Jagged1 knockout mice, a model for Alagille Syndrome (AGS), also

72 X receptor; Small Heterodimer Partner double knockout mice, a model for bile acid overload, display c

73 Reducing levels of TNFalpha in PGRN knockout mice abolished excessive self-grooming and the

74 l of peanut allergy and anaphylaxis, various knockout mice, adoptive transfer experiments, and in vit

75 s for Advanced Glycation End Products (RAGE) knockout mice after postnatal day 3, an identical OT inc

76 Wild-type and knockout mice alike all acquired cocaine-CPP and exhibit

77 wild-type and various inflammasome component knockout mice also revealed the process of asbestos-indu

78 Intriguingly, Kif14 knockout mice also showed primary microcephaly.

79 rossed dysferlinopathic BlaJ mice with TSP-1 knockout mice and assessed disease progression longitudi

80 sis in culture and in vivo Using conditional knockout mice and derived white and brown preadipocytes,

81 e conducted in xeroderma pigmentosum group A knockout mice and diethylnitrosamine-injected mice, both

82 Here we generated Arid1b-knockout mice and examined heterozygotes to model human

83 comprehensively studied erythropoiesis using knockout mice and hematopoietic progenitors.

84 n, IP3R levels were elevated both in Herpud1-knockout mice and Herpud1 siRNA-treated rat cardiomyocyt

85 e acid levels are normal in a subset of NTCP knockout mice and in mice treated with myrcludex B, a sp

86 I was induced in Cd36(-/-) Mertk(-/-) double-knockout mice and led to increases in myocardial rupture

87 ol synthesis during development of the Cyp51 knockout mice and provide in vivo evidence that sterol i

88 models of podocyte damage (WT1 heterozygous knockout mice and puromycin aminonucleoside-treated rats

89 e liver DNA of xeroderma pigmentosum group A knockout mice and remarkably reduced HCC incidence in th

90 METHODS AND We used H- and K-Ras gene knockout mice and subjected them to pressure overload to

91 iotensin II into endothelial-selective Epas1 knockout mice and their littermate controls.

92 ed in hepatocytes from GCN5L1 liver specific knockout mice and their upstream regulator, FoxO1 protei

93 Conditional knockout mice and transgenic mice expressing recombinase

94 Mixed bone marrow chimeras, conditional knockout mice, and adoptive transfer models were also us

95 as assessed in conscious TRPC6 wild type and knockout mice, and in anesthetized rats with and without

96 d-type and Sglt1-knockout mice but not Sglt2-knockout mice, and injection of SGLT2 inhibitors prevent

97 cnga2 knockout mice are congenitally anosmic and have abnormal

98 c mechanisms are unclear since the CB2R gene knockout mice are constitutive gene knockout.

99 Conditional knockout mice are generated using labor-intensive method

100 d toxin-induced stresses; we show that Gfral knockout mice are hyperphagic under stressed conditions

101 Interestingly, liver specific Ant2 knockout mice are leaner and resistant to hepatic steato

102 renal epithelial cells and tissues from Pkd1-knockout mice as well as in ADPKD patients.

103 was induced in hypercholanemic OATP and NTCP knockout mice, as well as in myrcludex B-treated cholest

104 Inhibition of calpain using calpain knockout mice attenuated airway smooth muscle remodellin

105 Using beta-cell-specific, inducible PKD1 knockout mice (betaPKD1KO), we examined the role of beta

106 ine this possibility, beta-cell specific TFG knockout mice (betaTFG KO) were generated.

107 collected from isolated adipocytes of gp130 knockout mice blunted Pcsk1 expression and GLP-1 release

108 b) and genetic (in patients with XLA and Btk knockout mice) BTK ablation in primary immune cells led

109 ney cortexes of rats and wild-type and Sglt1-knockout mice but not Sglt2-knockout mice, and injection

110 s were reconstituted in T-cell receptor beta knockout mice by adoptive transfer, and bone turnover, b

111 mg/kg/d for 4 weeks) in male C57BL/6J Sirt2 knockout mice, cardiac-specific SIRT2 transgenic (SIRT2-

112 Salmonella colonization in IEC-specific CD73 knockout mice (CD73(f/f)Villin(Cre) ) revealed a nearly

113 In the MC-specific Nrp2 knockout mice, circuit formation of Nrp2(+) MCs and odou

114 In knockout mice, clearance mechanisms are identified for n

115 pathogenesis of psoriatic arthritis in Fhl2 knockout mice coincided with enhanced levels of soluble

116 was also detected in FV-infected granzyme B knockout mice confirming that the exocytosis pathway was

117 In double-knockout mice, constitutive phosphorylation of EIF2A and

118 Conversely, Glp1r knockout mice consumed greater quantities of nicotine th

119 However, only double-knockout mice continued to exhibit low liver Hamp at 8 w

120 Partial Glrb knockout mice demonstrated an agoraphobic phenotype.

121 ion exhibited by adult GC receptor epidermal knockout mice demonstrated that keratinocyte-derived GC

122 er LPS or nephrotoxic serum, the podocyte GR knockout mice demonstrated worsened proteinuria compared

123 h were not impaired in muscle-specific GLUT4 knockout mice, demonstrating that GLUT4 is not necessary

124 Female Cx3cr1 knockout mice develop 'male-like' hypothalamic microglia

125 lated in skin cancer stromal cells, and Atf3 knockout mice develop aggressive chemically induced skin

126 We also show that Zfp106 knockout mice develop severe motor neuron degeneration,

127 elitis because NFM-deficient synonymous with knockout mice developed an identical disease course to w

128 because only 46% of PGE2-administered COX-2 knockout mice developed anastomotic leakage (P = 0.02).

129 In addition, Wap-Int3/P50 knockout mice did not develop mammary tumors.

130 VHR-knockout mice did not have obvious abnormality; however,

131 ring Bmal1 expression in the brains of Bmal1-knockout mice did not rescue Bmal1-dependent sleep pheno

132 Id1/Id3 knockout mice die at mid-gestation with multiple cardiac

133 Almost all Armc5 knockout mice died during early embryonic development, a

134 However, Prdm16 germline knockout mice died neonatally, preventing us from testin

135 Homozygous Cdk10-knockout mice died postnatally with severe growth retard

136 s effect was replicated in vivo, where Ifit2 knockout mice displayed a dramatically more severe disea

137 After injury, STAT3 knockout mice displayed attenuated astrocyte hypertrophy

138 ke receptor 7 agonist imquimod (IMQ), Trim32 knockout mice displayed compromised psoriasiform phenoty

139 lls, and wounds of epidermis-specific alpha9 knockout mice displayed delayed vascular normalization a

140 val, and wounds of epidermis-specific alpha3 knockout mice displayed impaired angiogenesis.

141 Indeed, compared with wild-type mice, MLKL knockout mice displayed more severe AKI.

142 calmodulin-dependent protein kinase II gamma knockout mice displayed reduced CAC.

143 RAGE-knockout mice displayed striking impairment of tumor cel

144 R-dependent because Meto infusion in beta3AR knockout mice does not elevate circulating S1P levels, n

145 l/6 mice or tumor necrosis factor receptor 2 knockout mice, either fed a high-fat diet for 12-14 week

146 Indeed, IL4I1 knockout mice exhibit an accelerated B cell egress from

147 In addition, double knockout mice exhibit an impaired cardiac response to ca

148 rast, the kidneys of IL-36 receptor (IL-36R) knockout mice exhibit attenuated TILs after UUO.

149 midal neurons from the hippocampus of Celsr3 knockout mice exhibit loss of approximately 50% of gluta

150 that skeletal muscle stem cells from Deltex2 knockout mice exhibit precocious myogenic differentiatio

151 MiR-211 knockout (-/-) mice exhibited a progressive cone dystrop

152 ed gene expression, whereas Tsc1 conditional knockout mice exhibited changes in genes regulating TGF-

153 We also found that Dio2-knockout mice exhibited enhanced bleomycin-induced lung

154 mdx-knockout mice exhibited lower muscle force/endurance as

155 UO-treated wild-type mice, UUO-treated IL-36 knockout mice exhibited markedly reduced NLRP3 inflammas

156 s hepatocyte and macrophage Bmp6 conditional knockout mice exhibited no iron phenotype.

157 Unexpectedly, Syn-2 knockout mice exhibited paradoxical superior glucose hom

158 On a normal salt diet, dKO and single-knockout mice exhibited similar activation of the renin-

159 indicate that the interscapular BAT of Ucp1 knockout mice exhibits mitochondrial disruptions that ex

160 Parkin knockout mice exposed to aortic constriction-induced car

161 A previous report indicated that GPR55 knockout mice fail to develop mechanical hyperalgesia, s

162 In the Klhl31-knockout mice, FlnC protein levels were highly upregulat

163 sing BACE1 (beta-site APP cleaving enzyme 1) knockout mice for general health and neurological functi

164 ssential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with ele

165 ore, SSRIs protected both wild-type and SERT knockout mice from behavioral despair induced by chronic

166 do-/-) mice but not macrophage-specific LKB1-knockout mice grew faster and showed enhanced vascular p

167 btained from homozygous or heterozygous Tet2 knockout mice had larger atherosclerotic lesions in the

168 Liver tissues from FXR-knockout mice had reduced expression of urea cycle prote

169 In addition, liver FXR-knockout mice had reduced hepatic expression of enzymes

170 docyte-specific glucocorticoid receptor (GR) knockout mice had similar renal function and protein exc

171 steoclast-lineage-specific Gna13 conditional knockout mice have a severe osteoporosis phenotype.

172 Armc5 knockout mice have compromised T-cell proliferation and

173 Hlx heterozygous knockout mice have defects in brown-like adipocyte forma

174 whereas intestine-specific Sirt1 homozygous knockout mice have reduced development of colon cancer.

175 TRPV1 knockout mice have reduced glutamatergic innervation of

176 Human genetic studies and analyses of knockout mice have revealed their involvement in multipl

177 ng protein null mice (Mttp-LKO, i.e., double knockout mice) hepatic steatosis was greatly diminished

178 consistent with encephalitis in control and knockout mice; however, intranuclear viral inclusions we

179 inia virus (VACV) by scarification to IL-1R1 knockout mice (IL-1R1(-/-)) and found that these mice de

180 Gria1 knockout mice, in contrast, showed sustained performance

181 Additional analysis of homozygous Mirta22 knockout mice, in which no alteration is observed in the

182 orientation; however, evidence from tectorin-knockout mice indicates that confinement is important.

183 Instead, IMQ treatment of Trim32 knockout mice induced AD-like phenotypes with enhanced s

184 Immunodeficient MyD88-knockout mice infected with S. aureus experienced lethal

185 lithium responsiveness, we found that Pde11a knockout mice (KO) given 0.4% lithium chow for 3+ weeks

186 cortex (mPFC), and therefore generated NRG2 knockout mice (KO) to study its function.

187 86, they fail to do so in double conditional knockout mice lacking both NF186 and the paranodal cell

188 Similarly, knockout mice lacking the LPA-degrading enzyme phospholi

189 rganic anion transporting polypeptide (OATP) knockout mice (lacking Slco1a/1b isoforms), and human OA

190 Pkd1 and Smyd2 double-knockout mice lived longer than Pkd1-knockout mice.

191 ype (WT) and liver-specific Foxo1/3/4 triple knockout mice (LTKO).

192 entified as essential in human cell lines or knockout mice may be distinct from those in living human

193 We report that liver-specific Mttp knockout mice (Mttp-LKO) exhibit both steatosis and fibr

194 IL-12p35, IL-23p19, and IL-12/IL-23p40 knockout mice on a C3H/HeN background, subjected to a me

195 ctor underlying binge eating in heterozygous knockout mice on a C57BL/6N background that showed reduc

196 In liver FXR-knockout mice on a high-protein diet, the plasma concent

197 ceptor interacting serine/threonine kinase 1-knockout mice or their WT littermates.

198 broblasts from dynamin1 like (DNM1L) protein-knockout mice or their WT littermates.

199 IH-induced aorta changes were absent in CD36 knockout mice, Our results provide mechanistic insights

200 s of in vitro-polarized TH2 cells from Spi2A knockout mice (P < .005) and in vivo after ovalbumin cha

201 Panx1 knockout mice (Panx1(-/-)) were protected from hypersens

202 A was compromised after IMQ treatment in the knockout mice, phosphorylated Stat6 was elevated.

203 In addition, Tsc1 conditional knockout mice presented severely disorganized collagen f

204 was linked to sudden arrhythmia death in VCL knockout mice prior to the appearance of cardiomyopathy.

205 In Syt7-knockout mice, Purkinje cell and vestibular synapses exh

206 In the knockout mice, reconstitution of Ormdl3 transcript level

207 miR-155 knockout mice recovered from influenza infection faster

208 However, GPR55 knockout mice remain incompletely characterized in model

209 type platelets into platelet-specific CLEC-2 knockout mice restored thrombosis.

210 K508R mutant transgene in heterozygous Flcn knockout mice resulted in development of multi-cystic ki

211 Experiments in knockout mice revealed a major role for TLR2, a lesser r

212 n of dKO mice with wild-type (Wt) and single knockout mice revealed additive effects of Gsta4(-/-) an

213 Analysis of the Bmp6 conditional knockout mice revealed that liver endothelial cells (ECs

214 using protein kinase C epsilon (PKCepsilon) knockout mice, RNA interference against PKCepsilon, and

215 Endothelial-specific S1pr1 knockout mice (S1pr1(iECKO) ) showed BBB breach for smal

216 Both RPGR and Gelsolin knockout mice show abnormalities of actin polymerisation

217 with Apoe(-/-) controls, EphA2(-/-)Apoe(-/-) knockout mice show diminished atherosclerotic plaque for

218 Finally, TC-PTP knockout mice showed a shortened latency of tumorigenesi

219 Selenbp1-knockout mice showed biochemical characteristics similar

220 Raptor conditional knockout mice showed decreased extracellular matrix (ECM

221 Analyses of macrophages from Tet2 knockout mice showed elevated expression of several chem

222 Compared with control littermates, knockout mice showed impaired glucose tolerance and circ

223 Relative to wild-type littermates, knockout mice showed no gross pathologies.

224 Akt1 expression also increased in AVF; Akt1 knockout mice showed reduced fistula diameter and wall t

225 ytes isolated from wild type and podocyte GR knockout mice showed similar actin stress fiber staining

226 e was evaluated in 129SJ/wild-type and SIRT3-knockout mice (Sirt3(-/-) ) by using fibrosis scoring an

227 xpressed with p-Creb in renal cysts in Itf88 knockout mice subjected to ischemia and Six2cre;Pkd1(Fl/

228 in humans and developmental defects in Abl1 knockout mice, suggest that ABL1 has an important role d

229 did not blunt fibrosis in Ppargc1a- or Pink1-knockout mice, suggesting dependence on these pathways.

230 ch beneficial effects were abolished in Aqp4-knockout mice, suggesting that the AQP4-dependent glymph

231 1 was displaced in fibers of nesprin 1alpha2-knockout mice, suggesting that this interaction may play

232 otinib was 2.6-fold higher in Abcb1a/b;Abcg2 knockout mice than in WT mice, measured as percentage in

233 CRTC2 knockout mice that express one CRTC3 allele (CRTC2/3m mi

234 rapid lymphoma development in Id2/Id3 double-knockout mice that is caused by unchecked expansion of i

235 s was observed in PAI-1(-/-)/uPA(-/-) double knockout mice that was associated with reduced inflammat

236 ing revealed a decrease in beta-cell mass in knockout mice that was caused by a 39% reduction in beta

237 uestion, we produced triple cKO (conditional knockout) mice that allow ablating all neurexin expressi

238 In uncoupling protein 1 (UCP-1) knockout mice, the middle and highest doses of the beta3

239 dy response of murine splenocytes from FVIII knockout mice to FVIII in vitro and in vivo.

240 s end, we generated retinal-specific Tmem30a-knockout mice to investigate its roles in vivo for the f

241 sed viral receptor expression in D2 receptor knockout mice to show distinct effects of calcium signal

242 e also generated apoE(-/-)/As3mt(-/-) double knockout mice to test whether As3MT-mediated biotransfor

243 Moreover, exposure of type-I interferon knockout mice to ZIKV results in severe damage to the te

244 ical studies in Hey2(+/-) (Hey2 heterozygous knockout) mice to dissect the underpinnings of the 6q22.

245 logic (beta-blockers), and genetic (beta2-AR knockout mice) to reduce adrenergic stress signaling in

246 osite approach and crossed mdx mice with ApN knockout mice, to obtain mdx mice with ApN depletion.

247 We generated conditional EHD1/3/4 knockout mice using CD4-Cre and crossed these with mice

248 Conditional knockout mice utilized a new iCre driven by the Esr2 pro

249 AV2/8 1:3 capsids and injected them into FIX knockout mice via the tail vein.

250 t increased platelet activation in the TRAF3 knockout mice was not due to increased expression platel

251 e-selective allosteric modulators along with knockout mice we now report that the effects of mGlu2/3

252 tiple cytokine and cytokine receptor subunit knockout mice, we demonstrate that stem cell transplant

253 Using conditional knockout mice, we examined the electrophysiological, bio

254 ing a combination of chemical inhibitors and knockout mice, we found that IL-10 induction in B cells

255 Using a genetic approach with conditional knockout mice, we identified IECs as the dominant IFN-la

256 In SPARC knockout mice, we performed an injury study to investiga

257 Here, using dual conditional knockout mice, we show that genetic redundancy of Gata3

258 Surprisingly, both wild type and FcRn knockout mice were able to mount an immune response agai

259 ns in tumorigenesis in myeloid-specific Egfr knockout mice were accompanied by decreased macrophage,

260 s, hyperglycemic TSP-1(-/-)/ApoE(-/-) double knockout mice were compared with age-matched hyperglycem

261 Hdac6 knockout mice were crossed with F508del (CF) mice to gen

262 y potassium loading and restriction, KS-WNK1 knockout mice were deficient in these structures under i

263 Ormdl3 knockout mice were found to be protected from developing

264 Here, we show that TRIM21 knockout mice were highly susceptible to Toxoplasma infe

265 In addition, Ehmt1(+/-) knockout mice were impaired at fear extinction and novel

266 Enteroids derived from control and ATP7B-knockout mice were incubated with excess Cu or with Cu-c

267 Wild type and FcRn knockout mice were injected once with either infliximab

268 Global HCN1 knockout mice were less successful and exhibited atypica

269 e analyses of conditional heart-specific p53 knockout mice were performed.

270 Double knockout mice were protected against fasting-induced hep

271 Thus, tau- and amyloid protein precursor-knockout mice were protected against lithium-induced iro

272 uced asthma model, we report here that TRPV4-knockout mice were protected from D. farinae-induced air

273 T-cell subsets in T-cell receptor beta knockout mice were reconstituted by adoptive transfer wi

274 Wild-type and cathepsin K knockout mice were rendered diabetic by streptozotocin (

275 anhedonic behavior and by evidence that RAGE knockout mice were resilient to stress-induced anhedonia

276 IRF1-knockout mice were resistant to ConA-induced liver damag

277 Calpain conditional knockout mice were studied in the model.

278 Male C57BL/6J wild-type and Sirt2 knockout mice were subjected to the investigation of agi

279 Homozygous Otud6b knockout mice were subviable, smaller in size, and had c

280 n, surgical transplant and novel conditional knockout mice were super-ovulated and analyzed.

281 HAT-L4 knockout mice were viable and fertile.

282 Psip1 knockout mice were viable but showed several defects in

283 SMC-Nampt knockout mice were viable but with mildly dilated aortas

284 l line models RAW264.7 and THP-1, as well as knockout mice, were used to identify the cellular and mo

285 ulated in mouse hepatocyte nuclear factor 4A knockout mice; were early-stage tumors by Barcelona Clin

286 the hemochromatosis phenotype of global Bmp6 knockout mice, whereas hepatocyte and macrophage Bmp6 co

287 by in situ hybridization, and generate Armc5 knockout mice, which are small in body size.

288 Interleukin-1 receptor type I knockout mice, which display braked immune response and

289 ed through the creation and analysis of Hmmr-knockout mice, which suffer neonatal lethality with defe

290 ression, as did podocyte-specific PPAR-gamma knockout mice, which were more sensitive to adriamycin a

291 hality and severe phenotypes in the complete knockout mice while mice with a partial loss-of-function

292 urrent study, we crossed our Lpd conditional knockout mice with a mouse line expressing Cre under the

293 Use of GC receptor epidermal knockout mice with adrenalectomy allowed for the distinc

294 However, RIPK3 knockout mice with AKI had less inflammation than their

295 ur genotypes were generated by breeding Nox1 knockout mice with db/db mice: lean (HdbWnox1), lean Nox

296 prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead i

297 Reconstitution of irradiated Panx1 knockout mice with hematopoietic Panx1(-/-) cells engine

298 We found that NANOS2 knockout pigs phenocopy knockout mice with male specific germline ablation but o

299 culture or in vivo after challenge of Spi2A knockout mice with ovalbumin in alum.

300 on, but also in WSX-1/tristetraprolin double knockout mice, with substantial reduction in the number