ライフサイエンスコーパス: knuckle

1 tead of the target EbaaagbE turn (rubredoxin knuckle).

2 d also packs against the amino-terminal zinc knuckle.

3 between the RNA binding domain and the zinc knuckle.

4 teine-rich region, predicted to fold as a Zn knuckle.

5 rmed the finger, beta-ball, thumb, palm, and knuckle.

6 re-specific binding by NC's single CCHC zinc knuckle.

7 c finger proteins containing rubredoxin-like knuckles.

8 t and third loops, which form two rubredoxin knuckles.

9 CSD) and a pair of retroviral-type CCHC zinc knuckles.

10 ins share a unique structure, with both zinc knuckle and cold shock RNA-binding domains, and were ori

11 eir side chains toward the space between the knuckle and finger domains.

12 A8 packs against the amino-terminal knuckle and forms a hydrogen bond with conserved Arg32,

13 ) helix that packs against the proximal zinc knuckle and interacts with the RNA stem.

14 (iii) Regions containing zinc knuckle and major homology region motifs, characteristic

15 at mnm encodes a conserved protein with zinc knuckle and RING finger domains.

16 The knuckle and the first turn of the helix each incorporate

17 Surprisingly, both the zinc knuckle and the RING finger are needed for RNA-binding a

18 that the linker regions between the two zinc knuckles and between the N-terminal RNA binding domains

19 e1 are a ubiquitin-like (UBL) domain, a zinc knuckle, and a RING finger domain characteristic of some

20 ins (KH and QUA2 domains) and the first zinc knuckle are important for binding to RNA.

21 rms of a more compact structure in which the knuckles are in close proximity.

22 The first and third knuckles are invariant, but the second shows some differ

23 ional correlation times, indicating that the knuckles are not tumbling as a single globular domain.

24 ef aroma over time when steaks from pre-aged knuckles are stored in retail display under high oxygen

25 milar, two of the studies indicated that the knuckles behave as independently folded, non-interacting

26 Both the human and Xenopus Zn knuckles bind to a variety of nucleic acid substrates, w

27 mily; N=A,U,G or C), and the C-terminal zinc knuckle binds to residues that flank SL-A, including res

28 he zinc ion resembles that of the rubredoxin-knuckle, but there are significant differences in hydrog

29 taining major homology region (MHR) and zinc knuckle (CCHC) motifs, separated by a pre_C2HC motif (mo

30 t CLP's C-terminus, containing two CCHC zinc knuckles, confers a binding preference for RNAs that con

31 The N and C-terminal "zinc knuckles" (Cys-X(2)-Cys-X(4)-His-X(4)-Cys; X=variable am

32 ve orientations of the N and C-terminal zinc knuckles differ in the NC-SL2 and NC-SL3 complexes, and

33 This suggests that one finger-knuckle disulfide bond (E235C/K393C) sets the channel in

34 N relaxation data indicate that the two zinc knuckles do not interact with each other, but instead be

35 that multiple residues in the alpha subunit knuckle domain contribute to the mechanism of Na(+) self

36 Deletion of the peripheral knuckle domain of the alpha subunit in the alphabetagamm

37 tematically mutated individual alpha subunit knuckle domain residues and assessed functional properti

38 ites within either the beta or gamma subunit knuckle domain resulted in little or no change in Na(+)

39 deletion of either the beta or gamma subunit knuckle domain within the alphabetagamma trimer dramatic

40 oney murine leukemia virus nucleocapsid zinc knuckle domain.

41 though the structures of the individual zinc knuckle domains are similar, two of the studies indicate

42 nclusion that structural features of NC zinc knuckle domains can vary significantly among the differe

43 Binding is mediated by the two zinc knuckle domains of NC.

44 relaxation studies reveal that the two zinc knuckle domains possess different effective rotational c

45 sid protein (NC) contains two CCHC-type zinc knuckle domains that are essential for genome recognitio

46 with weakly interacting and non-interacting knuckle domains.

47 onniere injuries, jersey finger, and boxer's knuckle), flexor pulley injuries, and skier's thumb, sho

48 r cysteines, is a distant member of the "gag-knuckle fold group" of Zn2+-binding domains and appears

49 pus fragment indeed assumes the canonical Zn knuckle fold, whereas the human sequence remains unstruc

50 The proximal zinc knuckle folds in a manner that is essentially identical

51 ell as a movement of Glu-235 relative to the knuckle helix.

52 olvement of the second highly conserved zinc knuckle in RNA binding suggests that this zinc knuckle p

53 present data supporting a role for this zinc knuckle in RNA binding.

54 The N-terminal knuckle interacts with a conserved U(217)GCG tetraloop (

55 In particular, the N-terminal zinc knuckle interacts with an A-U-A base triple platform in

56 ue extra C-terminal domain containing a zinc knuckle-like motif containing 4 cysteines.

57 the central zinc ion and consists of a zinc knuckle, loop, beta-hairpin and an alpha-helix.

58 in particular sequences encompassing a zinc knuckle motif near its N terminus, modulate Trf4p activi

59 nding occurs through a highly conserved zinc-knuckle motif present in NC.

60 rved zinc-coordinating "CCHC array" or "zinc knuckle" motif common to the nucleocapsid proteins of ne

61 l Pol beta RNA polymerases, and the two zinc knuckle motifs of Air2p interact with the Trf4p central

62 with a fragment of Air2p comprising two zinc knuckle motifs.

63 s indicate that both the finger loop and the knuckle move away from the beta-ball residue Trp-233 dur

64 Chunks of knuckle muscle from pork and beef as well as of breast m

65 , including the Incoming Nucleotide Binding, Knuckles, NNRTI Adjacent, and 399 sites, located in the

66 Three of these sites (Knuckles, NNRTI Adjacent, and Incoming Nucleotide Bindin

67 either one of two different residues of the knuckle of a neighboring subunit opens the channel at ph

68 However, the distal zinc knuckle of MMTV NC exhibits a rare three-dimensional fol

69 ure was observed recently in the distal zinc knuckle of the Mason-Pfizer monkey virus nucleocapsid pr

70 The zinc knuckles of BBP are partially responsible for the enhanc

71 ains of capsid, and the N- and C-terminal Zn knuckles of nucleocapsid) have the same structures as th

72 ns of capsid, and the N- and C-terminal zinc knuckles of nucleocapsid) retain their fold and reorient

73 ect non-LTR retrotransposons with three zinc knuckles of the form: (1) CX2CX4HX4C, (2) CX2CX3HX4C, (3

74 to that observed previously for the two zinc knuckles of the human immunodeficiency virus type 1 nucl

75 amino- and carboxyl-terminal CCHC-type zinc knuckles of the NC protein and the G7 and G9 nucleotide

76 as follows: (1) touching the object with the knuckles of the right hand; (2) grasping the object with

77 T four-helix bundle contacts the hydrophobic knuckles of Vps36-NZF-N.

78 ural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, which show considerable p

79 ia, acral punctate keratoses, cheilitis, and knuckle pads, which we propose to be given the acronym P

80 the 1H NMR chemical shifts of isolated zinc knuckle peptides are very similar to those of the intact

81 An AF10 region consisting of a PHD finger-Zn knuckle-PHD finger (PZP) folds into a single module that

82 uckle in RNA binding suggests that this zinc knuckle plays a different role in RNA processing than en

83 QTL, LIGHT5, was identified as a tandem zinc knuckle/PLU3 domain encoding gene (At5g43630; TZP), whic

84 splicing factor because they contain a zinc knuckle, precipitate with 65% ammonium sulfate, and cros

85 ontains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.

86 taining the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.

87 CCTG expansion in the gene encoding the zinc knuckle protein CNBP causes a common form of muscular dy

88 nucleotidyl transferases, Trf4p, and a zinc knuckle protein, Air2p, mediates initial substrate recog

89 r4p; a poly(A) polymerase, Trf4p; and a zinc knuckle protein, Air2p.

90 e walking and support themselves on the hind knuckles, rather than the soles.

91 Similarity is most striking in the zinc knuckle region, a region characteristic of gag genes of

92 domain and fix the orientation of the two Zn knuckles relative to one another so that the nucleocapsi

93 mmunostaining of Cx26 in lesional palmar and knuckle skin was weak or absent, although its adnexal ex

94 effect of a segment located upstream the Zn knuckle that is highly conserved and rich in positively

95 robably in parallel with the known AG target KNUCKLES to terminate floral stem cell fate.

96 ks; 3, movements in hind limbs but unable to knuckle walk; 4, no movement, drags hind limbs.

97 lized for suspension, vertical climbing, and knuckle-walking among extant African apes.

98 human bipedalism evolved from a terrestrial knuckle-walking ancestor or from a more generalized, arb

99 uggests that bipedal hominids evolved from a knuckle-walking ancestor that was already partly terrest

100 differs from that of later hominids and non-knuckle-walking anthropoid primates, suggesting that knu

101 e these data to test the hypothesis that all knuckle-walking apes share similar anatomical features a

102 ectations, features long-assumed to indicate knuckle-walking behavior are not found in all African ap

103 flexible forelimb while terrestrial fist or knuckle-walking demands more rigidity of the hand and wr

104 amined variation or development of purported knuckle-walking features in apes or other primates, data

105 The presence of purported knuckle-walking features in the hominin wrist can thus b

106 on the frequency and development of putative knuckle-walking features of the wrist in apes and monkey

107 ngly suggest that the ancestor of man used a knuckle-walking form of locomotion prior to becoming bip

108 Proponents of the knuckle-walking hypothesis focused on the wrist and hand

109 walking anthropoid primates, suggesting that knuckle-walking is a derived feature of the African ape

110 vertical climbing, forelimb suspension, and knuckle-walking that are seen in extant African apes.

111 ighly derived suspension, vertical climbing, knuckle-walking, and facultative bipedality of extant Af

112 ermits variation of locomotion: brachiation, knuckle-walking, etc., minor variations in structure det

113 vements, increased pronation/supination, and knuckle-walking.

114 typical of suspension, vertical climbing, or knuckle-walking.

115 ing any morphological traits associable with knuckle-walking.

116 specialized wrist morphology associated with knuckle-walking.

117 ndamentally different biomechanical modes of knuckle-walking: an extended wrist posture in an arborea

118 under body when walking but with ataxia; 2, knuckle walks; 3, movements in hind limbs but unable to

119 residues comprising and adjacent to the zinc knuckles were assigned by standard two-dimensional (1)H

120 n with two RNA recognition motifs and a zinc knuckle (ZD7), and a DNA/RNA helicase with a DEAD box (Z

121 (RRM), a CCHC type zinc finger domain (Zinc Knuckle, ZnK) and a C-terminal RS domain that is rich in

122 binding proteins that contain five CCHC zinc knuckles (ZnKs).