ライフサイエンスコーパス: label

1 drugs with required genetic testing in their labels.

2 ficity that correlates well with fluorescent labels.

3 eatures for both radiometal and radiohalogen labels.

4 ases, which provide well-defined but mutable labels.

5 lls form a 2D manifold that is fluorescently labeled.

6 se core granules was confirmed by immunogold labeling.

7 oup reported ignoring precautionary allergen labeling.

8 on isothermal amplification and fluorescence labeling.

9 s and to perfusion images from arterial spin labeling.

10 ed unambiguously by (13)C and (15)N isotopic labeling.

11 a similar stereotyped branching pattern DiI-labeling.

12 human and mouse cell lines measured by FLAER labelling.

13 -1 infected individuals (SWIFT-C) is an open-label, 2-cohort clinical trial in which the first cohort

14 expression of the RNA-binding protein Mex3a labels a slowly cycling subpopulation of Lgr5+ ISCs that

15 nal analysis from GATSBY, a randomised, open-label, adaptive, phase 2/3 study, done at 107 centres (2

16 Here, we have imaged fluorescently labeled AGs in live zebrafish mechanosensory hair cells.

17 otomy of deep and shallow diving states, and labelling all subsurface behaviour as deep dives or shal

18 ntramolecular side reactions during chemical labeling, allowing efficient chemical tagging with a red

19 Labeling along the antennal nerve, in projections of the

20 13)C2]Pro were the most abundant and rapidly labeled amino acids synthesized.

21 n structures within the parasite cytosol and labels an extensive F-actin network that connects parasi

22 ATOC as the foundation for developing a dual-labeled analog.

23 Deuterium labelled analogues of the target analytes were either pu

24 MSCs were fluorescently labeled and injected into a rat model of radiation-induc

25 nifold preservation process, we utilize both labeled and unlabeled data during training, making our m

26 at this approach is generally applicable for labeling and detection of suitable glycosaminoglycans.

27 Overall, this system allows stable labeling and monitoring of HIV genomic DNA within infect

28 ineering in mice enables the time-controlled labeling and monitoring of lipogenic or myogenic populat

29 Proximity labeling and protein interaction network analysis reveal

30 We have used isotope labeling and two-dimensional infrared spectroscopy to sp

31 The simplified binary labelling and classification of sexual behaviour in deme

32 Using 4sU RNA labelling and RNA-seq, we show this competition results

33 lood pressure (130-149mmHg vs <130mmHg; open label) and to antiplatelet treatment (aspirin/clopidogre

34 sizeable proportion of food products bear no label, and it is unclear whether these products are free

35 Using a combination of MS, isotope labeling, and (1)H and (13)C NMR techniques, we establis

36 location of nerve fibers that reacted with a labeled antibody against calcitonin gene-related peptide

37 owever, the pharmacokinetics of the Alexa750-labeled antibody formats showed shorter blood half-times

38 2-BODIPY)-OH (3-4 d), the preparation of the labeled antimicrobial peptide BODIPY-cPAF26 by solid-pha

39 Applying this labeling approach to structured illumination microscopy

40 have been possible without using the reverse labeling approach.

41 Using multiple labeling approaches to identify pathways and their posts

42 (2)) trajectory patterns were identified and labeled as follows-class 1: persistent, accelerating, ra

43 yl transferase-mediated dUTP-biotin nick end labeling assay and Hoechst staining.

44 cleotidyl transferase-mediated dUTP nick-end labeling assay was performed, and intestinal inflammatio

45 t candidate paper substrates for fluorophore-labeled assays.

46 luated the sensitivity and specificity of EV labeling assays in a manner that has not been described

47 Placement of a label at the C terminus yields the best biodistribution

48 ent functional groups for post-translational labeling at the specific amino acid positions.

49 ternative sequence in which a nitroxide spin label attached to cysteine has been introduced at its N-

50 y, and these changes are benchmarked against label-based image analysis of the mitochondrial network.

51 Using isobaric labeling-based quantitative proteomics, we simultaneousl

52 discriminated biobricks and inappropriately labeled biobricks.

53 magnetic molecules, nanostructures and spin-labelled biomolecules.

54 h the employment of seven whisky brands: Red Label, Black Label, White Horse, Chivas Regal (12years),

55 arallel-group, prospective, randomized, open-label, blinded end point trial, consenting patients with

56 international, prospective, randomised, open-label, blinded-endpoint trial in adult participants with

57 lticentre, parallel group, superiority, open-label, blinded-endpoint, randomised controlled trial, pa

58 Treatment allocation was open label but endpoints at 12 months were assessed by masked

59 identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive

60 Individual RNA molecules are labeled by hybridization and target proteins are concurr

61 Here we describe a new method for neuronal labelling by electrophoretic dye delivery from a suction

62 The fluorophore-labeled C2Am derivative showed predominantly renal clear

63 In this paper, we dissolve (13)C-labeled calcites in natural seawater.

64 isk while biogenic NER from incorporation of labeled carbon into microbial biomass are treated as deg

65 nalysis of the distributions of retrogradely labeled cells after focal injections of retrograde trace

66 The GFP-labeled cells include both proliferative globose basal c

67 Discrimination ability, an increase in BrdU-labelled cells in the subgranular zone of the dentate gy

68 In this article a multi-label classifier system is proposed that incorporates in

69 Part B of these randomised, phase 2, open-label clinical trials enrolled individuals from 15 count

70 We did a phase 4, open-label, cluster randomised trial of 22 communities in rur

71 We did an open-label, cluster-randomised ring vaccination trial (Ebola

72 gradation tests with radio or stable isotope labeled compounds enable the detection of the formation

73 ells eliminated lactate-dependent metabolite labeling, confirming tumor-cell-autonomous lactate uptak

74 The bases are labeled crystallographic hexagons.

75 ract to facilitate the transmission of a GFP-labelled cuticular bacterium.

76 by subpopulations.On the basis of nutrition label data from multiple sources, we used a stepwise app

77 an evaluation of its accuracy using manually labeled data.

78 al permeability, determined by fluorescently labeled dextran flux and transepithelial resistance, is

79 The EdU-labeled DNA was conjugated to fluor- or biotin-azide and

80 This was a phase 1, open-label, dose-escalating study done at four outpatient ret

81 Spin-labeled double-cysteine mutants of VcSiaP were analyzed

82 ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomised,

83 zation of target engagement of fluorescently labeled drugs, using fluorophores with a fluorescence li

84 study demonstrated that PSMA-11-derived dual-labeled dye conjugates are feasible for providing PSMA-s

85 entified by sequencing DNA barcodes uniquely labeling each of the tested cytokines.

86 -fibrin or fluorescein isothiocyanate-fibrin labeled emboli in anesthetized mice.

87 iation in tagged-ZnT8 expression and surface labeling enabled sorting of heterogeneous beta cells to

88 n-label phase (-126.3 minutes at 1-year open-label end point).

89 Anterogradely labeled endings in the DCN formed asymmetric postsynapti

90 The SNAP system consists of a self-labelling enzyme tag, which catalyses the covalent linki

91 three serine proteinase activity-based probe-labelled enzymes isolated was biochemically distinct, wi

92 Cell-surface labeling experiments indicate that the dominant form of

93 s chromatography-MS (GC-MS) data relative to labelling experiments.

94 2, reported here) for 12 weeks, and an open-label extension (part 3).

95 rolled study involving 186 patients; an open label extension study performed after the phase 3.

96 Phase IV, multicenter, open-label extension study.

97 volume, surface, and tabular data containing label, feature, and shape information for further analys

98 maize meal fortified with an MNP containing labeled FeSO4 (MNP) given with an RUTF (MNP+RUTF), with

99 Cb labels filamentous actin structures within the parasite

100 (18)F-labeled fluoroazomycinarabinoside ((18)F-FAZA) is a PET

101 The results demonstrated that covalent labeling followed by MS markedly increased the predictiv

102 etric analysis of basophil responses implied labeling for CD63, CD203c, and intracellular histamine.

103 re we present an automated method to extract labels for age, gender, and tissue from textual metadata

104 h serve as models in the search for new spin labels for DEER distance measurement at room temperature

105 enhance sensor stability and sensitivity for label free DNA and protein sensing for the first time.

106 ectable across clinically relevant levels by label free impedance derived redox capacitance.

107 eport on multiple virus quantification using label free method.

108 xtracellular signal-regulated kinase 1/2 and label free, in a parallel manner without affecting the m

109 Therefore a simple, rapid, label free, inexpensive, excellent, sensitive and select

110 d that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.

111 sciences.Photoacoustic microscopy allows for label-free 3D in vivo imaging by detecting the acoustic

112 ng (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing.

113 mass cytometry by time-of-flight provides a label-free approach for inorganic nanoparticle quantitat

114 ondary ion mass spectrometry (ToF-SIMS) as a label-free approach to chemically map small molecules in

115 iochemical composition of live cells using a label-free approach, confocal Raman microspectroscopy.

116 development of a 3D OrbiSIMS instrument for label-free biomedical imaging.

117 Optical manipulation and label-free characterization of nanoscale structures open

118 A non-faradaic label-free cortisol biosensor was demonstrated using MoS

119 f molecular bonds and is therefore ideal for label-free detection of chemical species.

120 d 30micromx7micromx5microm, which allows for label-free detection of explosive molecules such as trin

121 In this study, label-free fluorescence spectroscopy was used for the fi

122 Forming the basis of this cost-efficient, label-free immunoassay, CuONRs, synthesized using a simp

123 tering interferometry (BSI), a free-solution label-free method with high sensitivity, to quantify the

124 We report a label-free microfluidic technique to separate live and d

125 e, our mid-IR waveguide successfully perform label-free monitoring of various organic solvents.

126 ds in myelin at subdiffraction scales, using label-free polarization-resolved coherent anti-Stokes Ra

127 We present the use of dielectrophoresis for label-free quantification of intracellular mitochondrial

128 nst S/T/Y-containing peptides; additionally, label-free quantitation is used to ascertain catalytic e

129 Ultra Definition Mass Spectrometry (UDMS(E)) label-free quantitative approach.

130 Such an approach may find use in label-free selection of cells for a highly expressed mol

131 towards a fully integrated system for rapid label-free separation and on-chip phenotypic characteriz

132 assisted capture and mass spectrometry-based label-free strategy for studying the liver S-palmitoylom

133 cted within its clinical range with Raman, a label-free surface-enhanced Raman spectroscopy (SERS) ap

134 s subcellular nanostructure and devise a new label-free technique based on a spectroscopic analysis o

135 Here, we developed a label-free technique to determine the spatial distributi

136 Using label-free ToF-SIMS imaging mass spectrometry, we genera

137 eptide aptamer to create a novel, simple and label-free tool to detect abnormalities at an early stag

138 Here, we adopt a label-free, high-throughput, and continuous technique ut

139 This study evaluated the application of label-free, relative quantification of highly processed

140 demonstrated by Gclc targeted single-neuron labeling from the inducible Cre-mediated knockout (SLICK

141 M experiments with non-mutated fluorescently labeled Galphai1 subunits and alpha2A-adrenergic recepto

142 y (GC-MS) together with (13)C stable isotope-labelled glucose and glutamine as metabolic tracers, we

143 These NPs labels have excellent potential in biomedical diagnostic

144 which can be distinguished through isotopic labeling, have not been considered in past syntheses.

145 S) nanoparticles on the surface of [(89) Zr]-labeled hollow mesoporous silica nanoshells filled with

146 Hundreds of labeled hybridoma cells producing monoclonal antibodies

147 (0.17-3.02 mum) were obtained with different labels, imaging techniques and analysis methods.

148 This study used multiple labeling immunohistochemistry, confocal maging and analy

149 beling was observed in 36% and exclusive YFP labeling in 9%.

150 ative gel electrophoresis and stable isotope labeling in cell culture proteomics that the TbSTT3A and

151 The retention of GFP labeling in slowly dividing cells allowed for localizati

152 The isotopic labeling increases the vibrational lifetime about 2-fold

153 d and Drug Administration approvals, new off-label indications, and new competitors did not influence

154 tolerated with a toxicity profile similar to labeled indications.

155 aturated fat, or trans fat content.Nutrition label information (e.g., serving size, sodium, saturated

156 tigated the effect of kiwifruit puree (clean label ingredient) and high pressure homogenization on qu

157 nts were evaluated and discrepancies between labeled ingredients and detected species were noted.

158 Moreover, we show that the coumarin-labeled inhibitor can be used to image PI4KB in cells us

159 of analytical standards, including deuterium-labeled internal standards, are also described.

160 chemical synapse formation between sparsely labelled interneurons in clusters and the same nearby ex

161 some metabolites will have incorporated the labelling isotope, to a degree that depends on the metab

162 The combined effects of continuous labeling (label pumping), dynamic reversible binding, an

163 Both groups could receive open-label LAI for 84 additional days.

164 ells after gemcitabine treatment using iTRAQ labeling LC-MS/MS, because it was featured with the adva

165 ay be applied to many types of fluorescently labeled ligands and small diffusing particles, including

166 or (Mrgpr) family demarcate an itch-specific labeled line in the peripheral nervous system.

167 Here, using in situ (18)O isotope labelling mass spectrometry, we provide direct experimen

168 he construction of the descriptors: Property-Labelled Materials Fragments.

169 article provides an overview of recent (18)F-labeling methodologies, specifically for B-(18)F, Si-(18

170 sformation and algorithm adaption type multi-label methods and compare both to see which is preferabl

171 available for most organisms and alternative labeling methods are very limited.

172 docytic pathways suggest that uptake of EGFP-labelled mitochondria occurs via an actin-dependent endo

173 Single-arm, open-label, multicenter clinical study.

174 We did this single-arm, open-label, multicentre phase 3 study at 40 sites in Belgium,

175 Here we use isobaric-labeling multiplexed proteomics to analyze protein co-re

176 methylguanidine derivative (11)C-GMOM ((11)C-labeled N-(2-chloro-3-thiomethylphenyl)-N'-(3-methoxyphe

177 transporter-mediated uptake of fluorescently labeled NEFA in cultured proximal tubule cells and micro

178 Using Brainbow methods to label neighboring cells in different colors, we find tha

179 Phox2b-tdTomato labels nerve fascicles in the tongue of the developing e

180 g injections of retrograde tracers into DEn, labeled neurons appeared bilaterally in the infralimbic

181 wo-photon microscopy to target fluorescently labeled neurons.

182 tion < 0.05) compared with risk in nutrition label nonusers.There is an association between nutrition

183 ur laboratory, we identified and selectively labeled noxious-stimulus-activated PBL neurons and perfo

184 quently with cumulative exposure during open-label observation.

185 Approximately 90-99% of patients with a label of penicillin allergy (PenA) are not allergic when

186 of this conjugation chemistry enables facile labeling of bacteria.

187 mart probes greatly facilitate the selective labeling of biomolecules in living system.

188 Selective labeling of blood monocyte subsets indicates that non-cl

189 lary tufts by combining in vivo fluorescence labeling of endothelial cells, a novel tissue-clearing t

190 CD44 in breast cancer cells, we demonstrate labeling of fixed cells with high specificity that corre

191 directed nickase system directs the specific labeling of human (TTAGGG)n DNA tracts in genomes that h

192 Subsequent labeling of intermediate and nonclassical monocytes is c

193 etase (L274G) enables the cell-type-specific labeling of nascent proteins with a non-canonical amino-

194 This step was also devised to dual-labeling of PCR products with biotin and 6-FAM, which ar

195 Double-transgenic mice showed 55% double labeling of periurethral neuroendocrine cells expressing

196 The labeling of proteins with ubiquitin/ubiquitin-like (Ubl)

197 Cell-specific labeling of RNA can be profiled and imaged using bioorth

198 Control experiments showed no labeling of TG2 knock-out mice.

199 Here we use combinatorial labeling of zebrafish cranial neural crest-derived cells

200 Simultaneous ablation and labelling of cells using our system reveals roles for gl

201 Fluorescence microscopy demonstrated intense labelling of non-ghost and ghost tangles with PBB3 and A

202 B3 versus faint 18F-AV-1451 autoradiographic labelling of these tissues.

203 Text labels of cell lines from both ontologies were verified

204 uded the proportion of patients who were "de-labeled" of their AAL, spectrum of antibiotic courses pr

205 r, [11C]GV1-57, that appears to specifically label olfactory sensory neurons (OSNs), which are essent

206 By fluorescently labeling only a small fraction of cellular Pil1p, the ma

207 luated on multi-spectral images of multiplex-labeled pancreatic ductal adenocarcinoma (PDAC) tissue s

208 The ability to easily label pericytes in any mouse model opens the possibility

209 reduction was sustained throughout the open-label phase (-126.3 minutes at 1-year open-label end poi

210 SABRINA is a two-stage, randomised, open-label phase 3 study at 113 centres in 30 countries.

211 In this ongoing, multicentre, open-label, phase 2 trial, we enrolled adults (aged >/=18 yea

212 ACCL0431 was a multicentre, randomised, open-label, phase 3 trial that enrolled participants at 38 pa

213 In this open-label, phase 3, multicentre, international study, adults

214 tients and Methods In this multicenter, open-label, phase III trial, 2,012 women with early TOP2A-nor

215 controls, underwent amyloid ligand carbon 11-labeled Pittsburgh Compound B (PiB) positron emission to

216 ignals from cells reacted with fluorescently labeled probes is a widely-used method for assessing cel

217 r PCR, which through the use of fluorochrome labelled probes allows the target molecules to be detect

218 A robust and reliable kit-labeling procedure was established, allowing the prepara

219 d cell-surface analysis without the need for labeling processes.

220 The introduction of (18)F-labeled prostate-specific membrane antigen (PSMA)-target

221 ians, we investigated whether and how (68)Ga-labeled prostate-specific membrane antigen 11 ((68)Ga-PS

222 en choice of tag and the total expression of labelled protein, which has important implications for t

223 his reaction can be used to chemoselectively label proteins.

224 f the DiPyrO tag, characterize its effect on labeled proteome analysis by nanoLC-MS(2), and demonstra

225 The combined effects of continuous labeling (label pumping), dynamic reversible binding, and water de

226 Mimicry leads to fluorescently labeled pyoS2(NTD) being imported into FpvAI-expressing

227 luate the feasibility of within-suite (89)Zr-labeled radiotracer PET/CT-guided biopsy performed witho

228 We initiated this 24 week, open-label, randomised controlled, comparative effectiveness

229 In this international, open-label, randomised, phase 3, multicentre trial, we enroll

230 e conducted a prospective, multicenter, open-label, randomized phase III trial that compared a busulf

231 nt chemical tagging with a reduced excess of labeling reagent without intramolecular side reactions.

232 barcoding approaches require time intensive labeling, reduce the number of biologically meaningful p

233 subset of ependymal layer cells (ELCs) were label-retaining after a 140-day chase period.

234 Dual labelling revealed that ANO1 expression could be resolve

235 Importantly, dual-labeled ribosome-nascent chain libraries enable single-m

236 tion of individual molecules even in densely labeled samples and in cellular and tissue environments.

237 we combined specific and segmental isotopic labeling schemes with dynamic nuclear polarization (DNP)

238 tamination from erosion of anthropogenically labeled sediments elsewhere in the estuary.

239 h other molecular markers confirmed that the labeled SGNs were neither type I SGNs nor olivocochlear

240 We did a phase 2, open-label, single-arm study at six centres (hospitals and ca

241 ermore, a transgenic mouse line specifically labeling SL cells showed that they send profuse axonal p

242 k therefore extends the use of bioorthogonal labeling strategies to problems of clinical relevance.

243 faster substrate was excluded through (18)O-labeling studies.

244 Isotopic labelling studies support a mechanism where the hydride

245 We conducted a single-arm, open-label study in which 15 virologically suppressed HIV-1-i

246 e oligonucleotide targeting exon 51: an open label study including 12 patients; a phase 3 randomized,

247 andomly assigned (2:1) to switch to the open-label study regimen or continue the control regimen.

248 lled study for 16 weeks, followed by an open-label study with overall 40-week DHA treatment.

249 Further analyses revealed that categorical labels such as amusement better capture reports of subje

250 ces mobaraensis, a successful bio-orthogonal labeling system was demonstrated.

251 By using a retrograde labeling system, we defined the requirement of CSNs in t

252 tant and harshest metric for assessing multi-label systems.

253 Here, we used a stable isotope labeling technique ((18)O and (2)H) to determine the ori

254 Using genetic labelling techniques in zebrafish we were able, for the

255 cells and using detailed timecourses of DNA labelling that also distinguish the behaviour of recentl

256 nded to use click chemistry to fluorescently label the mature PG in whole bacterial cells of Bacillus

257 ative analysis of glycans can be achieved by labeling their reducing end using fluorescent tags.

258 ed electron microscopy combined with genetic labeling to define the three-dimensional arrangement of

259 ies and demonstrate the utility of proximity labeling to study the regulation of LD proteomes.

260 teomic technique, isotope-coded affinity tag labeling, to quantify the extent of NO2(-)-dependent S-n

261 However, the number of (18)F-labeled tracers addressing PSMA is still limited.

262 tion it is shown that ions arising from (2)H-labeled tracers are completely differentiated from those

263 differentiated from those arising from (13)C-labeled tracers, thereby allowing the enrichment of a tr

264 ic graphical models requires large number of labeled training samples, we propose to use simulated RN

265 ally classified into 10 categories to form a labeled training set, which can be used as a reference s

266 of MCF7 /: HER2-18 cells treated with (64)Cu-labeled trastuzumab (0.016-0.368 MBq/mug, 67 nM) for 18

267 17 of 7 following 8 weeks of randomized open-label treatment ADMs: escitalopram, sertraline or venlaf

268 We conducted an open-label trial to evaluate the safety, tolerability, and ef

269 In this randomised, phase 3, open-label trial, patients were screened for eligibility from

270 In this single-arm, open-label trial, we enrolled virologically suppressed, HIV-i

271 c, multicenter, randomized, controlled, open-label trials with blinded outcome evaluation: the POT-KA

272 l deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and phospho-histone H3 (PH3) staining t

273 By combining trans-synaptic labeling, ultrastructural analysis, calcium imaging, opt

274 Prospective open-label, unilateral single-dose, intravitreal injection of

275 Intravenously injected FAM-labeled UNO (FAM-UNO) homed to tumor and sentinel lymph

276 rs.There is an association between nutrition label use and diabetes risk in the longer term.

277 creased significantly with time (P-nutrition label use x time interaction < 0.05) compared with risk

278 conducted, which suggested that in nutrition label users, the HR of diabetes diagnosis risk decreased

279 -Zn(II) active site, were selectively (19) F-labeled using 3-bromo-1,1,1-trifluoroacetone.

280 Here we apply photoaffinity labeling using a propofol derivative, meta-azipropofol,

281 sma lumican FSR were measured based on (2) H labeling using tandem mass spectrometry.

282 ts received protocolized treatment with open-label venlafaxine, up to 300 mg/day for approximately 12

283 serotonin and YFP, whereas single serotonin labeling was observed in 36% and exclusive YFP labeling

284 ed with xyloglucanase, whereupon microfibril labelling was extensive.

285 rescence of proteins and immunohistochemical labels was maintained over weeks.

286 Here, using human in vivo deuterium labeling, we demonstrate that classical monocytes emerge

287 xpression and in vivo and in vitro metabolic labeling, we found that TbPSS2 (i) is necessary for norm

288 Using double-immunofluorescence labeling, we observed the potential colocalization of Tn

289 ent of seven whisky brands: Red Label, Black Label, White Horse, Chivas Regal (12years), Ballantine's

290 king water production plant, which cannot be labeled with (13)C.

291 This adnectin was labeled with (18)F to yield a PET radioligand for assess

292 expressing EGFRvIII targeting transgene were labeled with a perfluorocarbon (PFC) emulsion ex vivo an

293 Hodgkin lymphomas, many more sst2 sites were labeled with the antagonist than with the agonist.

294 complex, 3' overhang regions of the TRs were labeled with three distinct monolayer double-stranded (d

295 ietic stem and progenitor cells lentivirally labeled with unique oligonucleotide barcodes flanked by

296 Labeling with a fluorescent beta2AR ligand shows the rec

297 Double labeling with other molecular markers confirmed that the

298 that the hMSCs are minimally affected after labelling with IONPs.

299 Labelling with nanogold-conjugated CBM3, which binds the

300 he combination of a small number of specific labels with DNP NMR enables determination of architectur