ライフサイエンスコーパス: labile

1 Ag was weakly exchangeable and labile.

2 n vitro and in vivo is type III IFN and acid labile.

3 h the properties of muscle tissue are highly labile.

4 the protein and substrate is actually quite labile.

5 show that wild-type DHCR7 is also relatively labile.

6 tion in UV-absorbing area was evolutionarily labile.

7 ed with signal perception are evolutionarily labile.

8 period of reconsolidation during which it is labile.

9 s with NOM (mainly fulvic acid) are somewhat labile (0.2 </= xi </= 0.4), with kd = 7.5 x 10(-3) s(-1

10 age of this mutant in plasma to generate the labile 1-159 fragment.

11 2), and coupled assays were used to trap the labile (18)O atoms in the enzymatic products (i.e., isoc

12 out 1'-substituents, carries a metabolically labile 2',3'-ester group.

13 tive functional groups including highly acid-labile 2,3,6-trideoxy-sugar linkages.

14 was shown to contain a redox active and acid labile [2Fe-2S] cluster which is ligated by one histidin

15 y, and both memory and plasticity can become labile after reactivation.

16 tivity depends on the stabilization of their labile alpha subunit.

17 certain of these LC domains polymerize into labile, amyloid-like fibers.

18 for samplers with short expiration times and labile analytes; (5) two study-specific results reports

19 new and reactivated) memories are similarly labile and (re)established in a time-dependent manner wi

20 ring the summer 2015 fires, about 75% of the labile and 59% of the refractory radionuclides were expo

21 ring the spring 2015 fires, about 93% of the labile and 97% of the refractory particles ended in East

22 d by a biphasic model with approximately 61% labile and approximately 39% stable fractions at tempera

23 The zwitterion is highly labile and by visible or IR irradiation rearranges via a

24 Some forms of long-term memories become labile and can be reversed with specific types of reacti

25 induced apoptosis is regulated by the highly labile and ER-associated BCL-2 family member BOK, which

26 rieval of the drug-cue memory, which becomes labile and must be reconsolidated into long-term storage

27 roperties of DNA-assembled nanoparticles are labile and sensitive to interactions with counterions, w

28 d reactivated) memories are considered to be labile and sensitive to treatments disrupting the time-d

29 M resulting from both N enrichments was more labile and stimulated growth of copiotrophic Gammaproteo

30 renders the memory of an aversive event more labile and suggest a strategy to modify debilitating mem

31 the resulting conjugates are hydrolytically labile and thus are not suitable for structural and biol

32 ions in vivo, enabling analysis of low-dose, labile, and complex site-specific ADCs with linker-drug

33 -NO bond is approximately 0.2 A longer, more labile, and facilitates the release of HNO.

34 o enhance retrieval and render a memory more labile are unknown.

35 Rather a homolytic P-C bond cleavage in the labile aryl phosphine ligand and the reaction of low-val

36 resorption downflow, yielding a high load of labile As sorbed to the sediment at a depth of 35.8 mbgl

37 However, native Env on virions is innately labile, as well as heterogeneously and sparsely displaye

38 Covalent capture of these labile assemblies provides access to unprecedented archi

39 with rapid coevolutionary dynamics are more labile at branch tips.

40 and repetitive character while being highly labile at the sequence level.

41 fective catalysis is hence the presence of a labile auxiliary ligand in the catalyst resting state.

42 a second segment, 15-25 WT, forms non-toxic labile beta-sheets.

43 The thiosulfinate allicin is a labile, bioactive compound of garlic.

44 cetalated dextran (Ac-DEX) is a tunable acid-labile biopolymer with facile synthesis, aptly designed

45 nous blood collection and timely shipment of labile blood samples is difficult.

46 D peptide is synthetically replaced by a non-labile bond, shows an about 10-fold increased potency re

47 the subunits with a bias toward fragmenting labile bonds, UVPD spectra provided higher sequence cove

48 ations which caused the substitution of ClO2-labile by ClO2-stable amino acids.

49 They were made photo-labile by encapsulation of a NIR-triggerable photosensit

50 racterized the ability of fungal taxa to use labile C (glucose), intermediate C (hemicellulose or cel

51 sitivity of Rsoil was strongly influenced by labile C additions.

52 ure, as reflected by the finding that higher labile C in bamboo litter contributed the higher ratios

53 t, and maintain topological integrity of the labile C terminus of the alpha subunit (site A).

54 mboo litter contributed the higher ratios of labile C to SOC and lower ratios of recalcitrant C to SO

55 espond more positively to warming than would labile C-using taxa.

56 decomposition of bamboo litter with the high labile C.

57 ia increased plant belowground investment in labile carbon and associated enhancement of microbial tu

58 is revealed that the MAT only influenced the labile carbon pool size and not the SOC stability.

59 Additionally, the labile carboxylate group allows water to bind early in t

60 Significant release of DGT-labile Cd, Ni, Pb, and Zn, but lower Cu and Fe, occurred

61 tion, which may contribute to the release of labile cellular constituents into the extracellular envi

62 of glycans by MALDI mass spectrometry is the labile character of sialic acid groups which are prone t

63 ic nature of sensory patch formation and the labile character of the sensory-competent progenitors, w

64 understand the interplay between changes in labile characters, life histories and population dynamic

65 rthermore, this positive association between labile climatic niches and diversification was detected

66 se of structurally disordered and chemically labile Co(OH)2 is introduced to ensure a high concentrat

67 anic matter C is regarded as one of the most labile components of the soil C, such that can be easily

68 tively preserved in soil and that chemically labile compounds bonding to minerals comprise a large fr

69 Overall, the encapsulation of labile compounds in more complex systems needs to be car

70 -2-alkoxy-indeno[1,2-b]pyrano-4,5-diones are labile compounds since through an opening of the pyranon

71 the formulation of microcapsules loaded with labile compounds.

72 The ratios of DGT-labile concentrations to the average concentrations from

73 g numerous distinctive binding sites through labile coordination solvent molecules.

74 copper-binding tracker, results showed that labile copper is preferentially localized to the spore b

75 Mitochondria of eukaryotic cells contain a labile copper(I) pool localized in the matrix where also

76 stable, synthetic oligosaccharide analogs of labile CPS induce a specific protective immune response

77 emical footprinting was used to characterize labile, cross-beta polymers formed from the FG domain of

78 mild drought and were sufficient to suppress labile Cu concentrations.

79 he probe can detect physiological changes in labile Cu(+) levels in live cells and mice under situati

80 Here, the authors successfully perform MS on labile cyclic sulfur clusters by stabilizing them within

81 rial drug chloroquine specifically increases labile cytosolic heme, indicative of dysregulation of th

82 a cyclic form of t6A (ct6A) as a chemically labile derivative of t6A in tRNAs from bacteria, fungi,

83 nation of the Fe-H bond in [H1](0) to give a labile dihydrogen complex.

84 ta et al. propose that low concentrations of labile dissolved organic carbon (DOC) preclude prokaryot

85 Mechanically labile DNA duplexes presenting ligands are surface immob

86 below approximately 12 pN using mechanically labile DNA tethers.

87 demonstrates how the conversion of abundant labile DOC pools into methane results in some of the hig

88 ria may be lessened by the presence of large labile DOC pools that yield noncompetitive substrates su

89 olidation, a memory that is recalled becomes labile during which time it can be updated.

90 ic PSEN or APP mutations further destabilize labile E-S complexes and thereby promote generation of l

91 Many quantitative traits are labile (e.g. somatic growth rate, reproductive timing an

92 hese findings demonstrate that metabolically labile electrophilic groups can endow covalent drugs wit

93 The more labile elements escaped easier from the CEZ, whereas the

94 somer present in an equilibrating mixture of labile enamines.

95 PENK is a stable surrogate analyte of labile enkephalins that is correlated inversely with ren

96 a major effector molecule of ETEC, the heat-labile enterotoxin (LT), may enhance these interactions

97 ), a novel i.d. adjuvant of the type II heat-labile enterotoxin family, elicited strong systemic PspA

98 er spp. (OR: 1.46; 95% CI: 1.11, 1.91), heat-labile enterotoxin-producing E. coli (OR: 1.55; 95% CI:

99 Due to the labile ester containing link, this prodrug is converted

100 at least a fraction is incorporated through labile ether bonds.

101 viscoelastic properties of muscle are highly labile, exhibiting a strong dependence on movement histo

102 BMSC CM contained a heat-labile factor that increased BMMs osteoclastogenesis.

103 ion in iron homeostasis via sequestration of labile Fe(2+) into vacuolar compartments.

104 he probe can detect physiological changes in labile Fe(2+) levels in live cells and mice experiencing

105 We found that the intracellular, labile Fe(2+) pool was higher under anaerobic conditions

106 ed by a prompt increase of the intracellular labile Fe(II) pool (LIP).

107 ng through augmentation of the intracellular labile Fe(II) pool and DNA hydroxymethylation.

108 ustrating the catalytic potential of pairing labile first-row transition metal active sites with a mo

109 ronmental niches are highly phylogenetically labile for both seedlings and adult trees, with closely

110 The predominance of a relatively labile form of U((IV)) also provides an opportunity for

111 sruption of its homeostasis, particularly in labile forms that can contribute to oxidative stress, is

112 intended to represent the more oxidized and labile forms, were more effective for predicting the tox

113 order biphasic model with approximately 25% labile fraction and 75% stable fraction.

114 significant correspondence between the soil labile fraction and must is observed.

115 cted mostly in oligomeric form in the alkali-labile fraction and was enriched in tension wood.

116 ing relatively intense remineralization of a labile fraction of material in warm waters, followed by

117 Originally described as a heat-labile fraction of the serum responsible for the opsoniz

118 This indicates that the labile fraction of the soil represents the Sr reservoir

119 the Sr isotope composition contained in the labile fraction of the soil.

120 action, while in cold environments, a larger labile fraction undergoes slower remineralization that c

121 A labile fraction, representing 42+/-2% of the total activ

122 .5kJ/mol respectively for the stable and the labile fractions.

123 osition of bamboo litter increased soil C in labile fractions.

124 Thus, the anaerobic biodegradation of labile fuel components coupled with sulfate respiration

125 In particular, alkenes with oxidatively labile functional groups, such as alcohols, aldehydes, s

126 blanks suggesting significant loss (36%) of labile GOMTK from the denuder or inlet.

127 specific manner (e.g., fluorophores or photo-labile groups).

128 d heme a via neutral His413, regardless of a labile H bond between Ser382 and the hydroxyethylfarnesy

129 ltimately reliant on the ability to mobilize labile heme (LH).

130 r and endogenous heme contribute to cellular labile heme and that extracellular heme can be transport

131 Labile heme has been suggested to have an impact in seve

132 ans shows that environmental heme influences labile heme in a tissue-dependent manner; reporter activ

133 Quantitative analysis of labile heme is of fundamental importance to understandin

134 ium falciparum, we have quantified cytosolic labile heme levels in intact, blood-stage parasites.

135 Our findings indicate that a labile heme pool ( approximately 1.6 microM) is stably m

136 ent range to detect changes in intracellular labile heme.

137 However, gladiolin lacks the highly labile hexaene moiety of etnangien and was thus found to

138 eplete and -replete conditions to mobilize a labile His-Zn pool.

139 rbed Fe(II) (if Fe(II)SORBED > 8% clay Fe(II)LABILE); however, the kinetics of this conceptually surf

140 tide conjugated with doxorubicin via an acid-labile hydrazone linker as a function of local pH and ti

141 In sharp contrast to its extremely labile hydrocarbon counterpart, the fluoroalkene is very

142 We demonstrate the C-terminal 65 kDa to be labile in native proteolytic conditions in absence of th

143 d why sexual systems are more evolutionarily labile in some lineages than in others.

144 These needle-like domains are highly labile in the out-of-plane direction under applied elect

145 es apoptosis in cancer cells by chelation of labile inhibitory zinc from procaspase-3.

146 We analysed both the labile inorganic P (PILAB ), a proxy of the pool involve

147 Adding 'labile INR' (TTR < 65%) to ORBIT, ATRIA and HEMORR2HAGES

148 discrimination performance, but adding the 'labile INR' criteria (i.e. TTR <65%) to ATRIA, ORBIT and

149 Adding 'labile INR' to ATRIA, ORBIT and HEMORR2HAGES improved th

150 the incubation fitted well to a three-pool (labile, intermediate and stable) SOC decomposition model

151 lsant use (HR, 1.35; 95% CI, 1.04-1.75), and labile international normalized ratio (HR, 1.33; 95% CI,

152 renal or liver function, anticonvulsant use, labile international normalized ratio, and antihypertens

153 iver function, stroke, prior major bleeding, labile international normalized ratios, age 65 years or

154 pro-oxidant chemistry involving redox-active labile iron and H2O2.

155 other iron-transport proteins remain active, labile iron gradients build up across the corresponding

156 er, Pbvit(-) parasites have higher levels of labile iron in blood stages and are more sensitive to in

157 oietin receptor agonist reported to decrease labile iron in leukemia cells.

158 al iron bound weakly to cellular ligands-the labile iron pool-to generate a response that preserves s

159 ddition to stabilizing the siderophore-bound labile iron pool.

160 robe that enables longitudinal monitoring of labile iron pools (LIPs) in living animals.

161 o a model of ferroptosis reveals a change in labile iron pools during this form of cell death, provid

162 enables ratiometric fluorescence imaging of labile iron pools in living systems.

163 ions and is capable of detecting changes in labile iron pools within living cells with iron suppleme

164 revealed that Ent can chelate intracellular labile iron that is required for neutrophil oxidative re

165 cubation with cyanide, undergoes loss of the labile iron to yield a [4Fe-4S] cluster.

166 Therefore, targeted removal of mitochondrial labile iron via highly specific tools from these organel

167 s to increased accumulation of mitochondrial labile iron, as well as increased mitochondrial reactive

168 tochondria are the principal destination for labile iron, making these organelles particularly suscep

169 The labile iron-mediated oxidative damage caused by UVA to m

170 a trans-conformation, and the presence of a labile lactone in this core, many synthetic methodologie

171 ch is a direct consequence of (iii) having a labile lattice O that is able to directly participate in

172 Mechanically labile ligands dampen platelet activation, and the onset

173 in, we report a tactic of designing tumor-pH-labile linkage-bridged copolymers of clinically validate

174 Nanoscale carriers with an acid-labile linker between the carrier and drug are commonly

175 We found that hydrolysis of the acid-labile linker is incomplete because the pH range of 4-7

176 ystal defects through the splitting of a pro-labile-linker and the removal of the linker fragments by

177 oporous MOFs with robust metal nodes and pro-labile linkers were initially synthesized.

178 glycodendrimer-coated latex beads with acid-labile linkers) were synthesized.

179 ters was installed using a configurationally labile lithiated primary benzyl benzoate, resulting in h

180 hereas the soils under an invader that input labile litter (kudzu, Pueraria lobata) would have a grea

181 greater rates of production and produce more labile litter than natives.

182 il inhabited by native vegetation that input labile litter, whereas the soils under an invader that i

183 that encode the heat-stable (ST) and/or heat-labile (LT) enterotoxins, as well as surface structures,

184 o CPT molecules are connected by a reduction-labile maleimide thioether bond.

185 The labile memory could then be weakened by an extinction pr

186 n which transient neural activities of early labile memory in the MB are consolidated into stable LTM

187 ins unclear how the brain consolidates early labile memory into LTM.

188 e olfactory learning forms several phases of labile memory to associate an odor with coincident punis

189 profiling of many metabolites, intrinsically labile metabolites are often improperly measured or omit

190 The ability of complexes of hard and labile metal ions with one or more open coordination sit

191 wn to reliably determine the fraction of the labile metals species.

192 Balance of labile methyl groups (choline, methionine, betaine, and

193 Quantitatively, a significant use of labile methyl groups is in the production of phosphatidy

194 expression of key genes to minimize loss of labile methyl groups.

195 his approach, but sufficient to increase the labile microtubule mass of the axon, thereby increasing

196 stabilize the microtubules, but to increase labile microtubule mass to levels more conducive to axon

197 hat UVPD fragmentation reduces the extent of labile modification loss by up to approximately 60%.

198 supplemental activation, without losing the labile modification.

199 ology to include ultrastructural details and labile molecular components of the once-living animal.

200 odology is suited to other configurationally labile molecules (for instance, hydrazones and imines),

201 alent class of enzyme-labile Po, followed by labile monoester- and diester-P.

202 other taxa adapted to scavenge the soil for labile N forms.

203 nt, identified as the nonhumic, biologically labile, "N-peak", which may be responsible for stimulati

204 of sialic acids is challenging due to their labile nature during sample preparation and ionization.

205 in general, is undermined by the fluidic and labile nature of lipid bilayers.

206 The labile nature of phosphoryl groups has presented a long-

207 pecial mode is required for fossilization of labile neural tissue.

208 Wetlands, however, also became a source of labile Ni to littoral zones, which was linked to reduced

209 hile the hydrocarbon composition of the semi-labile (non-BCHyPy) fraction released by HyPy was determ

210 Mn2/3 )O2 is discovered, which utilizes the labile O 2p-electron for charge compensation during the

211 ted in newly flooded soils by degradation of labile organic carbon and associated changes in geochemi

212 els of soil moisture, nitrate, chloride, and labile organic carbon, influenced chlorination of SOM fr

213 thesis in groundwater and extreme paucity of labile organic carbon, they support diverse and abundant

214 tion of chloride or most additions including labile organic matter (glucose and maltose).

215 ling the decomposition rates and pathways of labile organic matter (OM) in hypoxic waters are not wel

216 The effect that labile organic matter strongly stimulated the chlorinati

217 n podsol soil-with consistent stimulation by labile organic matter that did overrule the negative eff

218 her stimulation at increased availability of labile organic matter.

219 n nitrate and water were added together with labile organic matter.

220 ents around oxygen atoms necessarily lead to labile oxygen electrons that can be more easily extracte

221 ptimal immune cover against this genetically labile pathogen.

222 ticity and maintain circuit stability during labile periods of circuit development.

223 ure the initial reaction product is a highly labile peroxide complex cis-[Pd(IPr)2(eta(2)-O2)].

224 ally precise NCs protected by H- ligands and labile phos-phines, with potentially more accessible act

225 stimated using an indirect technique, alkali labile phosphate (ALP), that assumes that vitellogenin i

226 fluoridated CKI1RD (a stable analogue of the labile phosphorylated form) were identical and similar t

227 indicated that lower molecular weight (MW), labile, phytoplankton-derived compounds were degraded fi

228 e present study, we replaced the potentially labile pipecolic ester group of previous FKBP51 ligands

229 lts support the stabilization framework that labile plant components are the main precursor of minera

230 Labile plant inputs have been suggested to be the main p

231 s production leads to a seasonal addition of labile plant material into the peatland ecosystem as lit

232 identified as the prevalent class of enzyme-labile Po, followed by labile monoester- and diester-P.

233 ro ovalbumin model and illustrated that acid-labile polymer can activate CD8+ T cells at an increased

234 s ability to contract by folding, becoming a labile polymer.

235 ource of copper used for COX biogenesis is a labile pool found in the mitochondrial matrix.

236 ely little is known about the maintenance of labile pools of this cofactor, which likely ensures its

237 2(NTD) induces unfolding by TonB1 of a force-labile portion of the plug domain that normally occludes

238 can potentially lead to improved analyses of labile post-translational modifications.

239 gical screening of a bioorthogonal palladium-labile prodrug of the nucleoside analogue floxuridine, a

240 ed: why has only the 2,4-isomer emerged as a labile protecting group?

241 scope, tolerating common functional groups, labile protecting units, and heteroaryl motifs.

242 valent interactions and efficiently transmit labile protein complexes.

243 es, alpha3D represents the most mechanically labile protein yet characterized by AFM.

244 e appropriate for organic compounds in which labile protons are not essential to the structure elucid

245 were manifested as changes in the number of labile protons exchanged to deuterons, or vice versa.

246 tudy of biological active compounds in which labile protons must not be exchanged by deuterium nuclei

247 n approximately 5-fold higher proportions of labile (reactive) iron than intact diatoms.

248 The presence of labile repeat arrays in all analyzed NRPE1 Ago-binding p

249 ore rigid holoprotein structure protects the labile retinoid moiety during vitamin A transport.

250 atrix can remarkably stabilize the otherwise labile S6 and S12 clusters in the polyaromatic shell not

251 Instead, a labile salt bridge acts as an incessantly active "agitat

252 Consequently, vaccines derived from heat-labile SAT viruses have been linked to the induction of

253 a cell surface abnormality and requires heat-labile serum factors.

254 ptide-resin cleavage and removal of the acid-labile side-chain protecting groups affords the crude pe

255 gy presented can also be applied to identify labile sites in other bacterial or viral proteins that c

256 ion studies in which potential metabolically labile sites on compound 1b were removed or modified, re

257 and DNA lesions (single strand breaks/alkali labile sites) were significantly increased in blood cell

258 inciple, SOC decomposition would decrease as labile SOC declines under field warming, but observation

259 But the decomposition of labile SOC was similar in warmed plots compared to the c

260 ration of Cu(I) tris-isocyanide nodes with a labile solvent ligand in a manner mirroring solution-pha

261 he contributions of the fraction of the ASCP-labile species varied from 43 to 63% (Cu), from 32 to 42

262 eration and synthetic exploitation of such a labile species.

263 t that consolidated memories return to their labile state when reactivated and need to be restabilize

264 e memory, but also to return the memory to a labile state, making it susceptible to interference.

265 an return a conditioned aversive memory to a labile state.

266 core of three beta-strands and shorter more labile strands at the termini.

267 porter ion yield especially for glycans with labile structures.

268 ere we introduce a bioengineered platform of labile substrate arrays that enable simple, scalable gen

269 As a proof-of-concept, we show that labile substrates generate size- and shape-controlled em

270 ctor (IGF) 1, IGF binding protein-3 and acid-labile subunit, along with antithrombin III, were all de

271 molecules, including the characterization of labile sulfated functional groups.

272 , along with a small group of evolutionarily labile targets.

273 ves the solvolysis of a transient and highly labile tertiary-propargylic hydroxylactam trifluoroaceta

274 Dimer-dimer interactions were more labile than the BH3:groove interaction within dimers, su

275 plant defenses might be more evolutionarily labile than the herbivore traits related to host associa

276 Based on previous reports that RCA is heat-labile, the Rubisco activation state was measured.

277 However, the small sizes of AIPs and labile thiolactone bond have hindered vaccine developmen

278 that heterometals such as bismuth stabilize labile Ti-oxo sulfate clusters in aqueous solution.[Ti22

279 Labile tissues occur abundantly in the sponges and are a

280 at caused amino acid substitutions from ClO2-labile to ClO2-stable residues in the viral proteins, wh

281 ions that are both structurally specific and labile to disassembly.

282 thin the liverwort tree but become much more labile toward the present.

283 h delivery system (PDS) with or without heat-labile toxin (LT) from Escherichia coli or subcutaneousl

284 hat the T3SS effector EspB of EPEC, and heat-labile toxin of ETEC were secreted.

285 -stable toxin (ST), with or without the heat-labile toxin, are among the four most important diarrhea

286 between theoretical and empirical studies of labile trait variation.

287 uantitative genetic models of inheritance of labile traits into age-structured, two-sex models that r

288 earch exploring the evolutionary dynamics of labile traits, a data-driven framework for incorporating

289 xia inducible factor (HIF)-2alpha, an oxygen labile transcription factor.

290 increased stability of the otherwise highly labile TTP mRNA.

291 However, capturing labile, unknown protein assemblies directly from cells r

292 The most labile V fractions, interpreted as weakly and strongly a

293 analytical variations associated with these labile vitamins.

294 These memories become labile when retrieved and must undergo reconsolidation i

295 ar analog of long-term sensitization, became labile with short-term heterosynaptic reactivation and r

296 memory is reactivated it becomes momentarily labile-with implications for the genesis, maintenance, a

297 o their active cleaved forms by chelation of labile zinc ions.

298 As proof-of-concept, we identified a labile Zn-site in the hepatitis C virus (HCV) NS5A prote

299 Here, we aim to (i) identify labile Zn-sites in viral proteins using guidelines estab

300 In viral proteins, labile Zn-sites, where Zn(2+) is crucial for maintaining