ライフサイエンスコーパス: lability

1 markedly suppresses ribosome conformational lability.

2 ty to sensory stimuli, and greater emotional lability.

3 l structural changes associated with cluster lability.

4 polarity, structural diversity, and sulfate lability.

5 cleotides was probed using phosphodiesterase lability.

6 novel explanation of "high-energy" N-P bond lability.

7 ult to prepare by other methods due to their lability.

8 cific criteria for explosive temper and mood lability.

9 ch element in TNF-alpha mRNA, increasing its lability.

10 age as a thiophosphate based on its chemical lability.

11 nt was added to assess the rate of change of lability.

12 aling during retrieval would increase memory lability.

13 f exacerbations, asthma severity, and airway lability.

14 GT and widen the range of considered complex labilities.

15 nt rated oppositional behavior and emotional lability (-0.175, p = <.0001 and -0.178, p = <.0001).

16 Affect lability (11%) and sedation (9%) were the most common ad

17 vity (16.0 vs 3.0 days, P = .001), emotional lability (15.0 vs 3.5 days, P = .002), noise sensitivity

18 Because of the ligand lability, 2 also undergoes hydrogenolysis and rapid exch

19 common symptoms are hyperactivity, emotional lability, a below average intelligence quotient, and sho

20 The lability also led to a hydrolysis product that terminate

21 between sex of the fetus and maternal airway lability among pregnant women with asthma.

22 provided complementary evidence about OSCs's lability and "artifacts" formation during the analytical

23 The N-linker region has high mechanical lability and acts as the primary stretch-sensor in twitc

24 While affective lability and anxiety/depression were elevated throughout

25 g particle size and mineral composition with lability and bioaccessibility in mine tailings subjected

26 process results in decreases in the chemical lability and bioavailability of the Pb without its remov

27 ar, we include the competition between viral lability and Brownian motion.

28 The simultaneous evolutionary lability and conservation of the network underlying wing

29 viour and discuss it in the context of metal lability and coordination changes.

30 Gd kinetic lability and cytotoxicity studies further confirm stabil

31 over, the SAR domain confers both functional lability and DegP-mediated proteolytic instability on th

32 tiffening that can exacerbate blood pressure lability and diastolic dysfunction under stress.

33 The simultaneous evolutionary lability and genetic complexity of host plant use in the

34 Acid lability and improved ligation efficiency were introduce

35 nsolidated aversive memories triggers memory lability and induces a plasticity-dependent reconsolidat

36 Anion lability and influence on the iron affinity and reductio

37 The mean scores for lability and intensity for each affective domain for pat

38 ning T251I and P587L induces extreme thermal lability and leads to synergistic nucleotide and DNA bin

39 to the fine-tuning of emotional stability or lability and may play a role in bipolar disorder.

40 tion, oromotor/oculomotor apraxia, emotional lability and mutism in patients after infratentorial inj

41 coordination equilibria, (iii) substitution lability and operative mechanisms for water exchange, (i

42 Conditions are given which minimize the lability and permit quantitative recovery of tritiated p

43 We conclude that oxygen lability and poor repair of Por and Oor are major contri

44 help reveal evolutionary pattern within this lability and potentially identify the changes that have

45 Thermal lability and protease-sensitivity studies demonstrated c

46 dala, two established markers of fear memory lability and reconsolidation.

47 ction of the pathways that regulate synaptic lability and stabilization, and suggest potential approa

48 H2), are consistent with a high substituent lability and the accessibility of both 1,1- and 1,2-subs

49 asurements of the time evolution of both the lability and the reactivation of refolded AP as a functi

50 eved to have the greatest effect on C-O bond lability and therefore the photochromic properties.

51 ss suggest that fauna prefer PHY, due to its lability and/or toxins associated with ASB; this may acc

52 easures (spirometry and peak expiratory flow lability) and estimated 20-yr ambient concentrations of

53 A) that utilizes the simultaneous stability, lability, and directionality of metal-ligand bonds to dr

54 iastolic function, augmenting blood pressure lability, and elevating cardiac metabolic demand under s

55 youths without anxiety/depression, affective lability, and mania (and with a parent with older age at

56 al measures of anxiety/depression, affective lability, and mania are important predictors of new-onse

57 developmental experimentation and structural lability, and may provide evidence of a critical link to

58 uding chorea, hyperactivity, tics, emotional lability, and obsessive-compulsive symptoms, can occur i

59 e EIIIA segment, evidence for conformational lability, and peptide sequences for probing EIIIA functi

60 /depression, baseline and proximal affective lability, and proximal subsyndromal manic symptoms (p<0.

61 s gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.

62 surfactants, such as CMCs, solubility, acid lability, and stability were studied.

63 s of Ag were linked to higher DGT-determined lability, and this varied as a function of aging and rel

64 The high-lability AP form slowly converts to the low-lability for

65 The rate of conversion from high- to low-lability AP was found to be linearly dependent on Mg2+ c

66 is responsible for the production of the low-lability AP.

67 This surprisingly large range of labilities (approximately 10(7)) indicates that reactivi

68 erienced by women using HC (irritability and lability) are not captured by a screening tool for clini

69 gators in a number of studies have used heat lability as a criterion for distinguishing these isozyme

70 However, its lability at 37 degrees C has limited its therapeutic pot

71 ysis supported the hypothesis that affective lability at baseline predicts a new-onset bipolar spectr

72 domain plays a key role in regulating Nrdp1 lability by promoting its assembly into an oligomeric co

73 s extrapolation is dangerous because thermal lability can be markedly affected by the solvent environ

74 karst-associated increases in organic matter lability cause shifts in biogeochemical processes toward

75 Peak expiratory flow lability, defined as percent daily maximum minus the min

76 enever the time is replaced with the product lability degree times t.

77 substrate, the variably increased rate of NH lability dictates a significant loss of dynamic stabilit

78 Heat lability distinguished GBS-F from peptidoglycan and lipo

79 to it as GNARLE (Global Nanos Associated RNA Lability Element).

80 However, owing to their lability elimination of sulfate groups upon desorption/i

81 associated with bipolar disorder: emotional lability, emotional dysregulation, and heightened reward

82 imilar to our studies on BaTiO3-xHx, hydride lability enables a low temperature direct ammonolysis of

83 doethanol necessitated by the high degree of lability endowed by the aryl azide moiety.

84 y, pain, cognition, depression and emotional lability, fatigue, sleep disturbance, head drop, prevent

85 alnexin displayed significant conformational lability for a chaperone and that heat treatment and cal

86 valent state, and they indicate an increased lability for ferrous ions in the enzyme.

87 -lability AP form slowly converts to the low-lability form in a first-order reaction with a character

88 s, the present study determines whether this lability has consequences for the passive stabilization

89 tes of enantiomers and common conformational lability, high fidelity homochiral or heterochiral self-

90 inherent robustness with a highly regulated lability, how it adapts to both rapidly and slowly chang

91 of transpeptidation and favoring the kinetic lability hypothesis.

92 cific criteria for explosive temper and mood lability identify disruptive youth who improve while rec

93 inattention, memory problems, and emotional lability/impulsivity were significantly improved with 50

94 dings provide a substrate for increased mood lability in adolescents, and provide a substrate by whic

95 studies provide evidence for conformational lability in and around the alpha-subunit 3-10 helix at r

96 Directed investigation revealed surprising lability in CDX2 occupancy of the genome, with redistrib

97 of membrane proteins is complicated by their lability in detergent micelles and by their association

98 M7 instead of TM2) results in conformational lability in detergent solution and more rapid cell-surfa

99 ious treatment for explosive temper and mood lability in disruptive children and adolescents.

100 d hypomania in bipolar disorders; trait mood lability in major depressive disorder.

101 esults in increased emotional reactivity and lability in mice.

102 Greater lability in terms of anger and anxiety and oscillation b

103 lysis due to their isobaric nature and their lability in the gas phase, as both types of peptides dis

104 ults identify loci of genetic and epigenetic lability in the mammalian genome but argue against a dir

105 d confounding effects when measuring element lability in the presence of nanoparticles.

106 This local-context-driven lability in the representation of complex sounds-a modul

107 dition, they suggest surprising evolutionary lability in traits previously interpreted to be conserva

108 study was to map the determinant conferring lability in Zn(II) binding by using finger pair chimeras

109 Kinetic lability in Zn(II) binding was mapped to the alpha-helix

110 s a significant interaction between glycemic lability index and average glucose level, and the odds o

111 to measure glucose variability, the glycemic lability index had the best discrimination for mortality

112 Higher glycemic lability index was not independently associated with mor

113 However, subjects with increased glycemic lability index, but lower average glucose values had alm

114 8.7) compared with those with lower glycemic lability index.

115 ude of glycemic excursions, and the glycemic lability index.

116 lly, as the serine residue promoting thermal lability is conserved among Mus musculus, Danio rerio, D

117 epigenetic metastability which confers this lability is due to the A(vy) transposable element.

118 triction to patients with critical metabolic lability is justified by the long-term need for immunosu

119 We conclude that apo A-I lability is required for HDL opacification, LF apo A-I d

120 d QT variability, a marker of repolarization lability, is associated with an increased risk for VT/VF

121 Evidence suggests that this acid lability may assist FMDV cell entry via an endosomal pat

122 This geometric lability may be a common feature of hydrophobic cavities

123 This lability may explain the absence of the [2Fe-2S]2+ clust

124 interval: -19.4, -0.4) difference in airway lability observed between women carrying female fetuses

125 anxiety (odds ratio=0.43), and irritability/lability (odds ratio=0.38).

126 y switch the binding site affinities and the labilities of barriers on the track, creating an energy

127 The labilities of these dynamic ion pairs in solution are th

128 Thus, studies relying on the lability of 2-LTR circles are open to reinterpretation.

129 The increased lability of 6 is probably because, unlike the 2,6-dinitr

130 This pressure lability of AKe is rather low for a monomeric protein an

131 The acid lability of aliphatic ketals, which often serve as prote

132 We exploited differences in the acid lability of amide bonds within high-molecular-weight (HM

133 cidification increased the retrieval-induced lability of an aversive memory.

134 ns that were fundamental to the evolutionary lability of angiosperm reproduction, and hence to their

135 tenuates arterial baroreflexes, and leads to lability of arterial blood pressure, damage to cardiac m

136 cardiovascular reflexes while also producing lability of arterial pressure, damage to cardiac myocyte

137 Because of the inherent lability of aspartyl phosphate bonds and the intrinsic p

138 n which Cfd1-Nbp35 interaction increases the lability of assembled FeS on the Nbp35 scaffold for tran

139 during redox transformation and implies the lability of biogenic noncrystalline U(IV) species in the

140 he studies shows remarkable diversity in the lability of boutons depending on the cell type from whic

141 To address this lability of CD154 mRNA, we examined the ability of cytop

142 in particular lineages pointed to a striking lability of centromeric regions that distinguishes the e

143 to be lower as a consequence of the enhanced lability of clusters in the derivative proteins.

144 ent can effectively change the speciation or lability of contaminant metals (copper, zinc and cadmium

145 ion and were of limited use for reducing the lability of contaminant metals in good quality biosolids

146 ibody-targeted imaging, but the high in vivo lability of conventional chelates has limited its clinic

147 ociative ligand exchange mechanism where the lability of coordinated water dominates the reactivity w

148 This work compares the intrinsic lability of different sulfonate esters, identifying new

149 s in field settings to assess the source and lability of dissolved organic matter in situ.

150 verned by a combination of the abundance and lability of DOC exported from land to water and produced

151 The lability of DOM is thought to vary with age, with younge

152 in controlled experiments may depend on the lability of fewer key traits.

153 The lability of FL3P, the high affinity of FN3K for FL, and

154 In contrast, the evolutionary lability of genetic sex determination in other groups re

155 To define the lability of genomic imprints during this dynamic period

156 The lability of H(-) in BaTiO3-xHx (x </= 0.6) allows H(-)/N

157 We discuss the evolutionary lability of histone methylation profiles and draw a dist

158 The lability of intersubunit interactions has hindered the p

159 gistic anion plays a role in controlling the lability of iron bound to FbpA in the transport process.

160 rity in the spectroscopic properties and the lability of iron release of this mutant to the H249A mut

161 ire cluster in solution despite the relative lability of its constituents.

162 etained as the primary aconitase because the lability of its exposed cluster allows E. coli to sense

163 Experimentally, the lability of metal-bound acetates is greatest for Mn(III)

164 may potentially be useful surrogates for the lability of metals for all exposure routes.

165 Based on the heat-lability of MMS-induced base damage, an assay was develo

166 The adolescent age is associated with lability of mood and emotion.

167 Studies of the alkaline lability of oligodeoxynucleotides containing formamidopy

168 nce of the IS1 region is responsible for the lability of p94 and Rt88 calpains in muscle and retina,

169 the effect of pathway length on evolutionary lability of pathway structure, we examined amino acid bi

170 ms (SNP) based on kinetic differences in the lability of perfectly matched (PM) and mismatched (MM) D

171 its biological relevance, the intrinsic acid lability of phosphoarginine (pArg) has impaired studies

172 erations, including antibody specificity and lability of phosphoepitopes, are covered, along with pot

173 ave temperature sensitivity varying with the lability of plant inputs.

174 , to enable a direct structural gauge of the lability of protons in a given material, which is correl

175 SEA-0400 stabilized dofetilide-induced lability of repolarization and suppressed early afterdep

176 in vivo, but added RRF does not increase the lability of ribosome-bound EF-G.

177 Our study highlights the lability of RNAi pathways, even within well-studied grou

178 Long-term speciation and lability of silver (Ag-), silver chloride (AgCl-), and s

179 Discrepancies were explicable by the heat lability of some mutants.

180 e another example of the enhanced mutational lability of such regions of the genome.

181 he matrix upon laser irradiation, reflecting lability of sulfo groups.

182 itive to alteration of both the quantity and lability of terrigenous dissolved organic matter (DOM) d

183 stereoelectronic factors contributing to the lability of the "high-energy" N-P bond.

184 d (7)Li{(1)H} NMR spectroscopy, owing to the lability of the [Li(14)(O(t)Bu)(12)Cl](+) cation.

185 The acid-lability of the acetal groups allows the release of ther

186 Lability of the acyl phosphate linkage has limited struc

187 tion, 205TAFLLNIQLFEELQELLTHDTK226 , and the lability of the adduct suggest the heme is attached to o

188 The lability of the alpha-subunit His E7 NepsilonH is found

189 was shown to be involved in the observed pH lability of the cluster, indicating that loss of this li

190 3 over the course of 12 h, demonstrating the lability of the Cr0-H2 bond.

191 the siRNA linked to the nanoparticle and the lability of the cross-linker are critical for efficient

192 The lability of the equatorial (eq) CH3CN groups in these co

193 tacts and the pH-independent backbone proton lability of the F helix are interpreted in terms of a ho

194 The flexibility and lability of the Fe-BPh interactions in these complexes e

195 The lability of the formamide group required that nucleoside

196 an HO-1 (hHO-1) protein; however, due to the lability of the full-length form, a rapid purification p

197 Due to the lability of the glycosidic bond, 8-nitrodG cannot be inc

198 his lesion are quite indirect because of the lability of the glycosidic bond.

199 immunogens have been frustrated by both the lability of the gp120-gp41 interaction and the weak asso

200 dicate that the decreased activity is due to lability of the hybrid 60S subunits.

201 hree dirhodium compounds correlates with the lability of the leaving groups and corresponds to the ex

202 tion at vacant sites, enabled by the overall lability of the ligand sphere and the absence of ligand

203 transverse the cellular membrane but to the lability of the ligands on the dirhodium core.

204 This would imply lability of the ligands to CuB.

205 with the ion migration rate depending on the lability of the metal-ligand interactions [Pb(II) faster

206 The lability of the N-P bond is central to the physiological

207 The lability of the NH(4+)-containing cage was also indicate

208 s the solvent polarity increased, so did the lability of the nitrosoamides.

209 In this study, we show that the lability of the O-GlcNAc moiety to low-energy collision

210 The acid lability of the oxabicyclic structure was exploited to e

211 e synthesis (SPPS) due to the intrinsic acid lability of the P( horizontal lineO)-N phosphoramidate b

212 The results have implications on the lability of the peptide conformation in biological membr

213 The lability of the peroxidase results from oxidation of the

214 In each case, lability of the phosphoaspartate linkage has hampered a

215 the lack of pHis-specific antibodies and the lability of the phosphoramidate (P-N) bond.

216 h HI-6 as the reactivator due to the extreme lability of the phosphoryl oximes formed by this oxime.

217 on the sulfur atom, we were able to tune the lability of the platinum-sulfur interaction of platinum(

218 The increased lability of the polysome-associated mutant HEXA mRNA sho

219 uced changes in HIF-1alpha is limited by the lability of the protein in normoxia.

220 ally and favor respectively the stability or lability of the receptor beta-arrestin complex, thus reg

221 as long been a challenge due to the inherent lability of the reduced cofactors.

222 vertex sites of the Au(140) core, where the lability of the slightly more ionic Au[bond]S bonds ther

223 We discuss how the lability of the species that make up the MOFs can affect

224 harides presents major challenges due to the lability of the sulfate modifications, as well as diffic

225 he different assays used; alternatively, the lability of the SWI-SNF-remodeled state might be differe

226 Since the acid-lability of the thioamide prohibits on-resin thioester s

227 glycosaminoglycans is challenging due to the lability of their sulfate groups, the high heterogeneity

228 nal modeling at the DFT level shows that the lability of these bonds can be controlled by steric pres

229 We show that evolutionary lability of these colors is associated with both morphol

230 Both the hydrophobicity and hydrolytic lability of these silicates can be (independently) contr

231 The variability and lability of these virus-host complexes on fractionation

232 The lability of this family of proteins relative to [2Fe-2S]

233 The lability of this gold-thiol linkage upon exposure to oxi

234 he 0.6 state results from the conformational lability of unlocked ribosomes formed during translocati

235 o 8.8:1 in the summer months, reflecting the lability of viral-culture specimens transported during w

236 Our results highlight the evolutionary lability of xylem traits with climate, and the leading r

237 These results indicate that the kinetic lability of ZF1/2 in vivo is a key component of Zap1 zin

238 ome reference), Xi; (3) the flexibility, or "lability", of the molecule at equilibrium, Lambda; and (

239 han others, conferring a layer of phenotypic lability over a core of genotypic stability; this core d

240 chemically stable and have profoundly low Ag lability over extended periods.

241 ded that this more likely reflects increased lability over that of the alpha-subunit, and not the abs

242 Emotional lability, personality changes, psychosis, and mania are

243 post activational recovery of native protein lability (probed by the susceptibility to GdnHCl denatur

244 ures of mania, depression, anxiety, and mood lability; psychosocial functioning; and parental age at

245 le glycosidic cleavage introduces a point of lability (pyranosyl-1-ene) that upon collisional activat

246 tanding of its biological targets due to the lability, reactivity, and "spectroscopic silence" that a

247 ountering acute heart failure or hemodynamic lability refractory to conventional therapy.

248 lope glycoproteins did not exhibit increased lability relative to the wild-type envelope glycoprotein

249 The conformational lability required for loop insertion must therefore be t

250 l, in which the base of SL1 has an optimized lability required to mediate a physical interaction betw

251 stricted to patients with critical metabolic lability resulting from the need for immunosuppression a

252 s) completed the Center for Neurologic Study-Lability Scale (CNS-LS) and an 11-point scale measuring

253 and depression (Center for Neurologic Study-Lability Scale (CNS-LS) and Patient Health Questionnaire

254 e >/=13 on the Center for Neurologic Studies-Lability Scale [CNS-LS]) were maintained, twice daily, o

255 er reductions in Center for Neurologic Study-Lability Scale scores than those receiving placebo (p <

256 th the validated Center for Neurologic Study-Lability Scale.

257 ession in forebrain causes higher "emotional lability" secondary to a unique pattern of molecular reg

258 ty accompanying the exacerbations; emotional lability, separation anxiety, nighttime fears and bedtim

259 however, the extent of formation of the low-lability species is related to the square of the Mg2+-in

260 Zn2+ alone to apo-AP produces only the high-lability species with no subsequent structural change, s

261 e of denaturation that characterizes the low-lability species.

262 Density characterization and heat lability studies indicated that the increased erythroid

263 comparatively little effect on quadricyclane lability, substitution at a bridgehead position with a m

264 rnalizing, subsyndromal manic, and affective lability symptoms.

265 the scores for the agitation/aggression and lability/tension factors.

266 ternal asthma, as assessed by greater airway lability, than is carrying a male fetus.

267 the wild-type enzyme and an increase in cold lability that is attributed to destabilization of the ac

268 rdination of mNT's [2Fe-2S] leads to cluster lability that is strongly dependent on the presence of t

269 ive alterations in regions of conformational lability, the beta(2)AR can be tailored to have optimal

270 However, because of its lability, the structure and properties of this larger co

271 Despite this lability, the unprecedentedly high specific activity of

272 tribution to tumor progression, and elevated lability through autoubiquitination contributes to the o

273 ge method in which we take advantage of this lability to controllably synthesize PbSe/CdSe core/shell

274 , and greater understanding of metal species lability to DGTs is needed before assuming equivalence b

275 dments that range along a gradient of carbon lability to four newly restored wetlands in western New

276 The range of DOC lability to microbes seems to depend on prior light expo

277 Permafrost and organic mat DOM had similar lability to photomineralization despite substantial diff

278 w that although the mutation confers thermal lability to the enzyme, the effect is relatively minor.

279 ProTides showing diminished carboxypeptidase lability translated to poor anti-HIV agents and vice ver

280 her SOC decomposition is driven by substrate lability under warming.

281 d upon mutation to stabilize the deamidation lability via a generally applicable orthogonal engineeri

282 dynamics, yet the underlying causes of niche lability vs. stasis are poorly understood.

283 This lability was apparently compensated by co-localization o

284 Ag lability was characteristically low in soils containing

285 The importance of cross-link lability was investigated by NaBH(4) reduction of the ra

286 The BgaS heat lability was investigated by ultracentrifugation, where

287 The generality of reversible lability was tested by applying the in situ esterificati

288 To probe the origins of this conformational lability, we have performed hydrogen exchange measuremen

289 rlying Nrdp1 protein self-regulation through lability, we investigated the structural determinants re

290 mperatures of duplex DNA, and their cleavage labilities were determined.

291 monitored throughout and the speciation and lability were determined in both fresh and 3-month aged

292 the 208-12 template demonstrate significant lability when they are not glutaraldehyde-fixed.

293 ction time variability, timing and emotional lability) which can be examined in the HCP data and in f

294 een considered impossible due to their photo-lability, which actually makes aryl iodides popular star

295 unterintuitively, despite its substitutional lability, which is mechanistically required for coordina

296 spiratory-like rhythmic network activity and lability, which may play an important role in generating

297 These findings lead to the hypothesis that lability with respect to conformations separated by an o

298 , while K170R had a much greater temperature lability, with a half-life of 0.36 h under these conditi

299 m Mn(3)MO(4) cubanes is controlled by ligand lability, with the Mn(IV)(3)CaO(4) OEC model being unrea

300 Together, these data reveal unexpected lability within the adipocyte PPARgamma cistrome and sho