ライフサイエンスコーパス: lack

1 d methodologies for answering this have been lacking.

2 ably important, but strong evidence is still lacking.

3 experimental evidence for this prediction is lacking.

4 vention and therapeutic strategies are still lacking.

5 in schistosomiasis japonica endemic areas is lacking.

6 bacteriuria management among inpatients are lacking.

7 tal research on nodal line fermions is still lacking.

8 networks in primary progressive aphasia are lacking.

9 of population-based implementation have been lacking.

10 d progression of the disease in childhood is lacking.

11 abolites, and their genetic control is still lacking.

12 e inflammatory proteins-1beta) when CD73 was lacking.

13 nding of the DDR at a physiological level is lacking.

14 he trait, but large-scale analyses are still lacking.

15 direct inhibition of MmpL3 activity is also lacking.

16 ndent of their antibody reactivity, is still lacking.

17 lasia, but appropriately designed trials are lacking.

18 s that mimic a realistic in vivo setting are lacking.

19 tal tests of this cross-ecosystem theory are lacking.

20 biology of ascovirus replication in vitro is lacking.

21 cross different clinical characteristics are lacking.

22 CBT at rest and during exercise are clearly lacking.

23 es for real protein structures are currently lacking.

24 approach to crystallize antibodies is still lacking.

25 tions for macroscopic applications are still lacking.

26 the long treatment of tuberculosis (TB) are lacking.

27 or clinical trials on cerebellar ataxias are lacking.

28 everity of disease and clinical outcomes are lacking.

29 after common general surgical procedures is lacking.

30 al scale and across different soil depths is lacking.

31 ects on different life-history strategies is lacking.

32 lic fatty liver disease (NAFLD) over time is lacking.

33 high-quality evaluations of these tests are lacking.

34 data approaches assessing sleep dynamics are lacking.

35 ates elicited by early-life social stress is lacking.

36 from the post-Aire MHCII(lo) stage has been lacking.

37 identifying these ICU patient subgroups are lacking.

38 of sex-biased behavior and pathology, but we lack a basic understanding of how sex differences in the

39 However, even the best-studied systems lack a complete picture of how diverse physical and chem

40 ite a large body of research, we continue to lack a detailed account of how auditory processing of co

41 cesses and abundant use in biotechnology, we lack a detailed understanding of the kinetics of nucleic

42 somes is reduced in uis4(-) parasites, which lack a parasitophorous vacuole membrane protein and arre

43 ILC2s lack a TCR and respond instead to locally produced cytok

44 ntrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction

45 As a consequence, PNPLA1-deficient mice lacked a functional corneocyte-bound lipid envelope lead

46 blocking agent (NMBA) panels and 17/44 (39%) lacked a NAP6-defined extended panel; many failed to scr

47 inic (1) born between 1945 and 1965, (2) who lacked a prior diagnosis of HCV infection, and (3) who l

48 d the proteins failed to regulate a promoter lacking a crucial NACbs.

49 annels (CLIC) are non-classical ion channels lacking a signal sequence for membrane targeting.

50 llagen-fibril formation was examined in mice lacking a tectorin-based matrix, epithelial cilia or the

51 owever, whether a SNARE such as STX11, which lacks a transmembrane domain, can support membrane fusio

52 mon bile duct (CBD) stenoses are complex and lack accuracy.

53 isplay hallmarks of active Wnt signaling but lack activating Wnt-pathway mutations, suggesting activa

54 These two analogues when used alone lacked activity against Acinetobacter baumannii and Kleb

55 An APP mutant lacking all C-terminal lysines underwent the most pronou

56 dings were corroborated by showing that MEFs lacking AMPK activity also failed to up-regulate IFN-bet

57 ly SODs are particularly unique in that they lack an electrostatic loop for substrate guidance and ha

58 However, we lack an understanding of how an interface can select som

59 the membrane-inserted state of SecA is still lacking and will be critical for elucidating the bacteri

60 Long-term survival data are lacking, and prognostic factors are not well defined.

61 treatments for many psychiatric diseases are lacking, and the emerging tools and approaches outlined

62 al IL-26 released by Th17 clones and rhIL-26 lacked antimicrobial potency against P. acnes.

63 Although lacking any effects on HHSteC transdifferentiation asses

64 Adult mice lacking beta-arrestin 1 selectively in hepatocytes did n

65 Moreover, fish lacking both Cnrip1a and Cnrip1b both maternally and zyg

66 Conversely, gene-deleted mice lacking both Mg29 and MLP protein showed a further reduc

67 iency, as residual ILCs are depleted in mice lacking both molecules.

68 urthermore, these cells were present in mice lacking both the Rag2 and the common gamma-chain (gammac

69 iple phenotype association analysis paradigm lacks breadth (number of phenotypes and genetic variants

70 ere seen in: testing repertoire [10/44 (23%) lacked BSACI compliant neuromuscular blocking agent (NMB

71 lanoma growth is drastically reduced in mice lacking c-Rel, but not p65, in Tregs.

72 nvolved in regulating lytic replication, but lacked capsid proteins.

73 st as an apparent demarcation line (a region lacking cells or with much lower cell density) between a

74 ctious extracellular virions (HSV(des)) that lack cholesterol and likely contain desmosterol.

75 by MHC I is however defective in hepatocytes lacking collectrin, an intracellular chaperone protein t

76 These tumors lack deregulation of APC/beta-catenin signaling componen

77 obial susceptibility, but sub-Saharan Africa lacks diagnostic capacity and antimicrobial resistance s

78 , growing preferentially as an endolith when lacking dissolved CO2.

79 ates of the total forest carbon (C) pool are lacking due to insufficient information on dead organic

80 Toxin-induced liver diseases lack effective therapies despite increased understanding

81 s highlight the importance of choosing cells lacking endogenous MA channels to assay the mechanotrans

82 AGN 211377 with a close structural congener lacking EP1 antagonism (AGN 197727), AGN 197727 was much

83 duce WT, ERalpha KO, or ERalpha KIKO females lacking ERE-dependent ERalpha signaling.

84 Mice lacking Erf in the embryo proper exhibited severe anemia

85 ce and/or an RNA modification act on viruses lacking ExoN activity.IMPORTANCE CoVs encode multiple an

86 Additionally, T-bet-deficient Treg cells lacked expression of the Th1-characteristic trafficking

87 Bordetella pertussis strains lacking expression of pertactin, a bacterial adhesin and

88 breast cancers (TNBC) are highly aggressive, lack FDA-approved targeted therapies, and frequently rec

89 Neurons lacking FMRP show aberrant mRNA translation and intracel

90 impacts of environmental variation is widely lacking for many habitats and communities.

91 An important factor generally lacking from these procedures are gambling related cues

92 We also find that cells lacking gcd1 and zwf1, which encode the first enzyme in

93 that mutant strains of S. praecaptivus that lack genetic components of a quorum-sensing (QS) apparat

94 Mice lacking GIRK channels in DA neurons exhibited increased

95 Prior to 15 weeks of gestation, these cells lacked hematopoietic in vivo engraftment potential.

96 for metastases was compromised when NK cells lacked heparanase.

97 design, used broad census geographic levels, lacked individual-level data, or when available, did not

98 on with wild-type but not mutant FKBP65 that lacks intact PPIase domains.

99 y releasing activated kinases from receptors lacking intrinsic catalytic activity.

100 introduction of T150D K5 mutants into KtyII-lacking (KtyII(-/-)) keratinocytes prevents keratin netw

101 udies of non-model or ancient organisms that lack large amounts of genomic DNA.

102 Neural progenitors lacking Lgl1 had decreased N-cadherin internalization an

103 own either of the PKM isoforms in A549 cells lacking LKB1, a serine/threonine protein kinase upstream

104 malities in chondrocyte distribution in mice lacking lubricin (Prg4), the major boundary lubricant of

105 The brain lacks lymph vessels and must rely on other mechanisms fo

106 amination of the orbital innervation in mice lacking Mafb has established that the stereotypical misi

107 ffective anti-WNV immune response when Tregs lacked MAVS, thereby demonstrating that Treg detection o

108 f cells upregulated Mdr1 in the ileum, those lacking Mdr1 displayed mucosal dysfunction and induced C

109 ngs of previous studies are inconsistent and lack mechanistic information.

110 Consequently, mice lacking miR-34/449 display infertility as well as severe

111 e produced following incubation of HOS cells lacking mitochondrial DNA (mtDNA) with functional exogen

112 ancer, we engineered mice with B lymphocytes lacking MRN, or harboring MRN in which MRE11 lacks nucle

113 mTORC1, mTORC2, or both, we showed that mice lacking mTORC1 or mTORC1/mTORC2 but not mTORC2 alone dev

114 omain enhances VSV-LUJV infection, and cells lacking NRP2 are deficient in wild-type LUJV infection.

115 Mutations lacking nuclear localization uncover a novel mechanism w

116 lacking MRN, or harboring MRN in which MRE11 lacks nuclease activities.

117 limited by its lack of reproducibility, its lack of a clear normal value, and the fact that it is no

118 This lack of a common framework of 'effectiveness' of mutuali

119 The lack of a homeostatic relationship implies that other me

120 more attenuated DENV isolates.IMPORTANCE The lack of a known correlate of protection and the failure

121 However, the lack of a large, unbiased and complete sample of accreti

122 graft-vs.-tumor immunity are hampered by the lack of a physiologically relevant, preclinical model of

123 A major challenge is the lack of a rapid and accurate point-of-care (PoC) device

124 ) remained unknown for a long time, due to a lack of a validated questionnaire to assess QoL in the N

125 plastics in the environment is hampered by a lack of adequate high-throughput methods for distinguish

126 ion has been difficult to achieve due to the lack of adequate optical microscopic resolution to study

127 of synthetic molecules remains limited by a lack of adequate technologies.

128 There was a lack of agreement between surrogate-decision maker and p

129 The need for increasing LRT treatments and lack of alphafetoprotein response to LRT independently p

130 The lack of an appropriately positioned active site residue

131 However, due to the lack of any stable flea cell line or a published flea ge

132 ear V2 epitope could be engaged, despite the lack of aspartic acid/glutamic acid encoded in the mouse

133 The overall lack of association between maternal PHIV status and pre

134 the scope of the outbreak combined with the lack of available approved treatment options, there was

135 often neglected pancreatic anomaly due to a lack of awareness of this entity.

136 This lack of awareness of transient intermediates represents

137 In addition, the lack of base stacking and the DeltaHvH/DeltaHcal ratio s

138 This is consistent with the lack of biophysical evidence for a central pattern gener

139 One potential explanation is the lack of capacity of this agent to penetrate the central

140 ons by activated platelets were abrogated by lack of CD40 on injected platelets.

141 We propose that the overall lack of changes in synaptic function and plasticity in D

142 ive for CD26 in combination with an aberrant lack of cKIT expression.

143 The lack of colonization resistance occurred when Clostridia

144 y, the results unequivocally demonstrate the lack of commutability of tryptic and cleavable SIL pepti

145 This is due primarily to the lack of compatible and orthogonal elements for predictab

146 Nevertheless, the lack of contamination by drugs may not be guaranteed.

147 of imprinting in placenta and cord blood; a lack of correlation of the methylome, transcriptome, and

148 gnosis confirmation with clinic records, and lack of cost data from other case-finding approaches com

149 We report a lack of cross-genotype immunity in the largest cohort of

150 (Hg) dynamics in the Arctic is hampered by a lack of data in the Russian Arctic region, which compris

151 occurrence of perseverative behaviors and a lack of deliberation during the SWM test.

152 his allergy is underdiagnosed because of the lack of diagnostic reagents.

153 The lack of direct IL-18R signaling in T cells, but not of I

154 This is partly due to the lack of disease models recapitulating the human patholog

155 The lack of effective chemotherapies for high-grade serous o

156 ountered in cancer treatment, and there is a lack of effective treatment.

157 Rituximab's lack of efficacy could be due to a considerable placebo

158 cally were unsuccessful because of toxicity, lack of efficacy, or both.

159 igen-specific cytotoxicity and near-complete lack of endogenous TCR Vbeta expression, consistent with

160 Beyond the personal factors, there is a lack of evidence on how environmental stimulation influe

161 However, due to the lack of evolutionary conservation amongst diverse viruse

162 ehavioural phenotypes have been impeded by a lack of experimental tools.

163 in attenuation of cocaine CPP extinction and lack of extinction-dependent changes in hippocampal PSD

164 tics (eccentric hilum, longitudinal fissure, lack of fissure branching, fissure ratio, and maximum gr

165 limitations in the number of samples and the lack of functional analysis to examine the effect of the

166 ly however, despite these severe features, a lack of functional ATM is still compatible with early li

167 The lack of functional improvement post-TAVR was predicted b

168 because of a final noninfectious etiology or lack of further follow-up or details regarding the antib

169 The lack of GABARAPs reduced Arf1 activation, which led to f

170 Among the Asn(297) mutants that result in lack of glycosylation and thus loss of effector function

171 The study of Tspan5 has been limited by the lack of good antibodies.

172 dictable patterns of behavior and a relative lack of habituation among patients with bipolar disorder

173 Due to a lack of high throughput glycan sequencing software, glyc

174 partly undeveloped, which accounts for their lack of high-frequency sensitivity.

175 Limitations of this study include the lack of identification of optimal risk thresholds, as th

176 yet prominent phenotype associated with the lack of IL-1R signaling in mice and support further inve

177 size, high binding affinity, good stability, lack of immunogenicity, and easy synthesis, aptamer GR-3

178 reatment delay and residual symptoms and the lack of improvement in treatment delay during the study

179 this has often been hampered by the relative lack of information about key free-living species.

180 applied to commercial roasted coffees due to lack of information on roasting conditions.

181 There is a lack of insight into the relationships between violent i

182 consensus on optimal strategies, due to the lack of institution-level studies of resuscitation pract

183 Lack of knowledge about effective primary care nursing r

184 However, there is a lack of knowledge about fecal microbiome composition in

185 We have addressed the lack of knowledge about posttranscriptional contribution

186 of these vaccines are in clinical trials, a lack of knowledge about the molecular basis that governs

187 However, there is a lack of knowledge as to which drug pharmacokinetic (PK)

188 ment of new therapies are still limited by a lack of knowledge of the functions and pathobiological m

189 plex oligosaccharides is often hindered by a lack of knowledge on the reactivity and selectivity of t

190 However, the lack of laboratory data for Earth's most abundant minera

191 he type of maternal infection as well as the lack of large-scale neonatal screening tools.

192 Skepticism abounds because of the lack of level 1 evidence.

193 lic liver diseases have been hampered by the lack of models.

194 perior sensitivity, prolonged stability, and lack of non-specific sensor fouling may enable long-term

195 Lack of ORF148 or ORF25 causes attenuation in vivo to a

196 ompounds remains unidentified because of the lack of parent ion preservation.

197 Age and lack of past alcoholism treatments were independently as

198 y arterial hypertension (PAH) is hampered by lack of pediatric clinical trials.

199 cription of several genes is affected by the lack of Poleta, and that Poleta is enriched over activel

200 is because of their inherent flexibility and lack of predictable structure.

201 ude the exclusivity of study sites to India, lack of prior HIV/HCV diagnosis confirmation with clinic

202 faithfully replicate prion diseases and the lack of rapid, sensitive biological screening systems.

203 However, there is a lack of real-world data to support this estimate.

204 ulation of sleep-wake homeostasis, including lack of recovery sleep and impaired behavioral adjustmen

205 Here, we show that the lack of regeneration of these populations began ca. 165

206 on of a totally implantable hearing aid is a lack of reliable implantable microphone.

207 ut its clinical role has been limited by its lack of reproducibility, its lack of a clear normal valu

208 g distance gene flow, genome properties, and lack of research.

209 rial design is challenging, due in part to a lack of robust biomarkers with predictive value, some op

210 o HNO2, but not to NO2(-), combined with the lack of S-nitrosation during anoxia alone or by NO2(-) d

211 -prion therapeutics have been impeded by the lack of screening models that faithfully replicate prion

212 There is a lack of simple and validated severity assessments that a

213 g of RNA localization has been hindered by a lack of simple, high-throughput methods for mapping the

214 due to technical issues associated with the lack of stability and high cost of the biological recogn

215 The lack of statistically robust relationships between IEPOX

216 However, there remains a lack of statistically sound frameworks to model the unde

217 To study how multistage killing and a lack of steady state influence the functional response,

218 equirement for a ketogenic diet, the assumed lack of structural brain defects, and the potential exis

219 Lack of structural information has precluded elucidation

220 This lack of structural tools is identified as a crucial bott

221 Unfortunately, the lack of structure in radiologic reports limits the abili

222 r purely theoretical pathogen systems, and a lack of studies occurring at the wildlife-public health

223 n of electrons across each GPNJ, so that the lack of substantial overlap between transmission lobes a

224 arker and pathway discovery, in spite of the lack of successful applications to human disease.

225 ecline in the host's clinical status and the lack of targeted therapies for TSS emphasize the need to

226 Moreover, we contend that the lack of taxonomic granularity and use of vague generic n

227 also demonstrate loss of LAT expression and lack of TCR signaling restoration in LAT-deficient cell

228 The relative lack of tetra- and penta-chlorinated PCDD/Fs suggested t

229 all short of being subject specific due to a lack of the necessary clinical data.

230 The lack of the s(2) modification also slows down the rearra

231 ent's immune response to FVIII, because of a lack of tolerance, leading to the formation of inhibitor

232 ence from the fossil record is hampered by a lack of unambiguous biomarkers.

233 mber of genes duplicated in Trisomy 21 and a lack of understanding of the effect of disease pathology

234 This gap in knowledge stems from a lack of understanding of the physics of surface structur

235 ion into early-phase patient trials, but the lack of validated biomarkers of disease progression pres

236 ifts, especially when more detailed data are lacking on dispersal dynamics, demographic processes und

237 L. amazonensis metacyclic promastigotes lacking one SODA allele failed to replicate in macrophag

238 e of other GTPases in this process is either lacking or inconclusive.

239 ble to induce apoptosis in cells genetically lacking p53.

240 Mice lacking Pd1 (Pdcd1) exhibited thermal and mechanical hyp

241 omains have similar affinities for membranes lacking PIP2, but the C2B domain dominates binding to PI

242 g intravenous injection of tumor cells, mice lacking PITPalpha develop fewer lung metastases due to a

243 ffect became particularly obvious in strains lacking polyphosphate, a newly recognized chemical chape

244 the germline, and the transcriptome of PGCs lacking PRC2 resembles that of nos-1nos-2 PGCs.

245 rior diagnosis of HCV infection, and (3) who lacked prior documented anti-HCV testing.

246 Consistently, we find that mice lacking PRMT8 also exhibit reduced hippocampus-dependent

247 re-expression of Ptprg only in liver of mice lacking Ptprg globally.

248 ohistochemically ER-positive metastases that lack receptor-binding functionality.

249 provide a useful guide: Peptide macrocycles lack regular secondary structures and hydrophobic cores,

250 omes was ruled out using DHLMP2A mice, which lack secreted and membrane-bound Ab, yet harbor marginal

251 ymocyte/Thy-1 autoreactive BCR knock-in mice lacking self-Thy-1 ligand, immunoglobulin light chain ed

252 Yeast lacking SGS1 accumulate R-loops and gamma-H2A at sites o

253 ar clones of a New World ZIKV available that lack significant attenuation, hindering progress toward

254 active inflammatory cells in granulomas, but lacks specificity for particular cell types.

255 We found that isogenic mutants lacking SPN, SLO, and both toxins are equally impaired i

256 Pressure overload in mice lacking SRC-2 induces an abrogated hypertrophic response

257 By contrast, heterochiral sequences that lack such persistence selectively attack bacterial membr

258 lished evidence of antiepileptic efficacy or lacking such evidence, we demonstrated that our set of r

259 he wake of this rapid growth, clinicians may lack sufficient information about tCS to inform their cl

260 ing have been associated with response, they lack sufficient sensitivity and specificity for clinical

261 Mutants lacking TAG or impaired of TAG hydrolysis show spore wal

262 Consequently, they lack the ability to increase the physiological salience

263 n of HSV-1 on DHCR24(-/-) fibroblasts, which lack the desmosterol-to-cholesterol conversion enzyme, r

264 Conventional bacterial typing methods lack the discriminatory power to confidently confirm or

265 Cryptochromes lack the DNA-repair activity of the closely related DNA

266 ubcutaneous infections, but these infections lack the draining sinuses and fungal grains characterist

267 idium thermocellum suggest that both domains lack the flexible hinge in BiFae1A, an observation that

268 ors predominantly express RIM2 variants that lack the interaction domain for Munc13.

269 actin machinery was intact, Cdc42 null cells lacked the ability to polarize their Golgi and coordinat

270 3 cell lines, while the PF-deficient mutants lacked the ability to stimulate, and the complemented PF

271 TSPyV genomes lacked the rearrangements typical for reactivating polyo

272 Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenot

273 mutations failed to complement yeast strains lacking the EEF1A ortholog showing a major growth defect

274 the 5'-UTR of the SEC61G, yielding products lacking the entire extracellular ligand-binding domain o

275 -FS variant led to a truncated CARD8 protein lacking the FIIND and CARD domains.

276 Cells lacking the IGF-1 receptor remain arrested as multipolar

277 A poly(organophosphazenes) hydrogel lacking the imidazole moiety, which physically interacts

278 We report that as a consequence AR variants lacking the LBD cannot be ubiquitinated in the cellular

279 lonal cells, HAP1-Deltab and HAP1-DeltaOSCP, lacking the membrane domain of subunit b or the OSCP, re

280 he natural allergen papain, mice selectively lacking the miR-17 approximately 92 cluster in ILC2s dis

281 pared to wild-type (WT) controls, while mice lacking the necroptotic effector MLKL, or both MLKL and

282 Pathological Tau mutants lacking the vesicle binding domain still localize to the

283 an IgG1 antibody with a constant region that lacks the ability to interact with Fcgamma receptors.

284 s a harsh microenvironment for islets and it lacks the ability to retrieve the graft.

285 s to the TPR domain of Sec72, even though it lacks the TPR-binding C-terminal residues of Ssa1.

286 al perception of speech/nonspeech stimuli or lack thereof, neural oscillatory activities at the singl

287 Ribosome profiling in ER-stressed cells lacking these factors revealed that Ire1-mediated cleava

288 icroorganisms that live in environments that lack this nutrient; thus, unusual enzyme reactions have

289 s many isolates of the African lineage virus lack this site.

290 However, the mycobacterial enzyme lacks this reverse activity, but the reason for this def

291 dence for its role in tumorigenesis has been lacking thus far.

292 d pulmonary immunopathology of chimeric mice lacking TLR2 in the hematopoietic compartment (TLR2KO-->

293 ding sites (TMBS1, ABS1, TMBS2, ABS2), Lmods lack TMBS2 and half of ABS1, and present a C-terminal ex

294 could be attractive therapeutic targets and lack upstream toxicity.

295 led by day 10 in neonatal FOXA2-deleted mice lacking uterine glands.

296 Both viruses lack vaccines.

297 sensitivity to osmotic and detergent stress, lacked very long lipopolysaccharide, was unable to invad

298 However, viruses lacking vp3 have abnormal shapes, indicating that the vp

299 Reduction of the POU domain TF Ventral veins lacking (Vvl) largely ameliorates the airway morphogenes

300 ve a more severe growth phenotype than cells lacking zwf1 We propose that in S. pombe Gcd1 and Idn1 a