ライフサイエンスコーパス: lack of

1 This lack of 21-3U HCV host factor activity correlated with r

2 d must, at least in part, be credited to the lack of a clear conceptualisation of the term.

3 limited by its lack of reproducibility, its lack of a clear normal value, and the fact that it is no

4 This lack of a common framework of 'effectiveness' of mutuali

5 However, the lack of a comprehensive mapping of WGDs within a major p

6 This lack of a definitive conclusion might have implications

7 m group toward the N-terminus and (B) to the lack of a helical kink upon ligand binding.

8 The lack of a homeostatic relationship implies that other me

9 more attenuated DENV isolates.IMPORTANCE The lack of a known correlate of protection and the failure

10 However, the lack of a large, unbiased and complete sample of accreti

11 Such efforts are impeded by the lack of a physiologically relevant, pre-clinical animal

12 graft-vs.-tumor immunity are hampered by the lack of a physiologically relevant, preclinical model of

13 A major challenge is the lack of a rapid and accurate point-of-care (PoC) device

14 nd other investigations, has been limited by lack of a robust gene knockout or knock-down technology.

15 rol respiration and locomotion; however, the lack of a robust source of human V2a interneurons limits

16 The lack of a second wave of ZIKV infection in most affected

17 deep learning - may offer a solution for the lack of a solid definition of "item."

18 The lack of a specific objective test has been raising subst

19 However, the lack of a suitable third-order nonlinear material greatl

20 edients has seldom been evaluated due to the lack of a suitable toolkit.

21 The lack of a vaccine hinders control.

22 ) remained unknown for a long time, due to a lack of a validated questionnaire to assess QoL in the N

23 th nonwhite race, younger age, male sex, and lack of access to health care.

24 plastics in the environment is hampered by a lack of adequate high-throughput methods for distinguish

25 ion has been difficult to achieve due to the lack of adequate optical microscopic resolution to study

26 e have thus far failed, largely because of a lack of adequate small-molecule-binding pockets on the R

27 of synthetic molecules remains limited by a lack of adequate technologies.

28 treat these deficiencies are hampered by the lack of adequate, accessible, and affordable diagnostic

29 f theoretical models have been proposed, the lack of advances made in developing a robust evidence-ba

30 There was a lack of agreement between surrogate-decision maker and p

31 The need for increasing LRT treatments and lack of alphafetoprotein response to LRT independently p

32 The lack of an appropriate small-animal model of dengue infe

33 The lack of an appropriately positioned active site residue

34 usion of macromolecules despite the apparent lack of an open cytoplasmic sleeve, forcing the reassess

35 The lack of animal models to experimentally study how infect

36 This lack of anti-tumour immunity is attributed to an absence

37 we find that poor myofiber repair due to the lack of AnxA2 does not result in chronic inflammation or

38 However, due to the lack of any stable flea cell line or a published flea ge

39 ome c pathway) but cannot compensate for the lack of AOX1A, suggesting a difference in the regulation

40 A lack of APP C-terminal lysines caused APP redistribution

41 neurons, where APP is highly expressed, the lack of APP leads to a dramatic increase in plasma membr

42 Notably, protection was achieved despite the lack of appreciable Env antibody titers.

43 properties of ECC couplons is limited by the lack of appropriate experimental and analysis strategies

44 disorders in the ICD system contributes to a lack of ascertainment and recognition of their importanc

45 ear V2 epitope could be engaged, despite the lack of aspartic acid/glutamic acid encoded in the mouse

46 The overall lack of association between maternal PHIV status and pre

47 ly checkpoint (SAC) to detect and signal the lack of attachment to spindle microtubules, and delay an

48 udes during attention and smallest P1 during lack of attention, that is, these levels of alpha rhythm

49 Lack of availability of durable, potent drugs in child-f

50 the scope of the outbreak combined with the lack of available approved treatment options, there was

51 often neglected pancreatic anomaly due to a lack of awareness of this entity.

52 This lack of awareness of transient intermediates represents

53 In addition, the lack of base stacking and the DeltaHvH/DeltaHcal ratio s

54 n the wake of mounting evidence suggesting a lack of benefit to the routine use of PACs, there has be

55 relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies for

56 This is consistent with the lack of biophysical evidence for a central pattern gener

57 The lack of C-strand maintenance leads to gradual shortening

58 One potential explanation is the lack of capacity of this agent to penetrate the central

59 eries, but this effect was also abrogated by lack of CD40 on injected platelets.

60 ons by activated platelets were abrogated by lack of CD40 on injected platelets.

61 The lack of cell culture has hindered studies of OvHV-2 biol

62 The lack of cellular tolerance in KF neurons correlates with

63 conformational change is likely caused by a lack of CH3 domain dimerization (due to the three "hole"

64 We propose that the overall lack of changes in synaptic function and plasticity in D

65 ive for CD26 in combination with an aberrant lack of cKIT expression.

66 l far from understood, which is impeded by a lack of clarity on their structures.

67 f tackling malnutrition; however, there is a lack of clear evidence to support its implementation.

68 The major limitation of our study is the lack of clinical follow-up of participants during life.

69 vary, due to assay incubation periods and a lack of clinical laboratories performing these tests.

70 In addition, there is a lack of clinical trials required to refine and update st

71 in with unanswered questions and suffer from lack of closure.

72 The lack of colonization resistance occurred when Clostridia

73 s has not been as widely employed due to the lack of commercially available halide building blocks.

74 y, the results unequivocally demonstrate the lack of commutability of tryptic and cleavable SIL pepti

75 This is due primarily to the lack of compatible and orthogonal elements for predictab

76 s efficient at inducing mutated fetuses, the lack of complete gene inactivation resulted in animals w

77 Due to the lack of comprehensive reviews in this emerging field, th

78 ound for S. aureus and M. catarrhalis, and a lack of confirmed case data limited the cutoff identific

79 systems for primary and safety outcomes, and lack of consensus on treatment parameters.

80 However, there has been a lack of consistent findings among CSF microRNAs studies.

81 f different diagnosis and severity criteria, lack of consistent scoring or grading systems for primar

82 Nevertheless, the lack of contamination by drugs may not be guaranteed.

83 d surfaces, but this method is hindered by a lack of control over monolayer density and by secondary

84 of imprinting in placenta and cord blood; a lack of correlation of the methylome, transcriptome, and

85 gnosis confirmation with clinic records, and lack of cost data from other case-finding approaches com

86 We report a lack of cross-genotype immunity in the largest cohort of

87 Despite the lack of cumulative or amplified effects, ranavirus drove

88 15 years) with larger tumor, hemorrhage, and lack of cyst.

89 ty was prescribed to hybrubin A except for a lack of cytotoxicity, we further profiled this unique al

90 rformed in those previous studies because of lack of data and knowledge at the time they were made, p

91 (Hg) dynamics in the Arctic is hampered by a lack of data in the Russian Arctic region, which compris

92 However, the lack of definitive data on spillover by microsporidia, i

93 occurrence of perseverative behaviors and a lack of deliberation during the SWM test.

94 overprescription of antibiotics as well as a lack of development of new antibacterial agents.

95 his allergy is underdiagnosed because of the lack of diagnostic reagents.

96 The lack of direct IL-18R signaling in T cells, but not of I

97 This is partly due to the lack of disease models recapitulating the human patholog

98 favorable baseline still corresponded with a lack of distant metastases.

99 iptional RNA folding has been limited by the lack of easily approachable methods that can interrogate

100 ht is not guaranteed, in part because of the lack of easily deployable diagnostic tools.

101 th factor antibody bevacizumab could explain lack of effect in diffuse intrinsic pontine glioma.

102 eins remains challenging both because of the lack of effective amplification approaches and the wide

103 The lack of effective chemotherapies for high-grade serous o

104 The lack of effective therapies for SEB exposure remains an

105 ountered in cancer treatment, and there is a lack of effective treatment.

106 us, studies from the USA reported a complete lack of effectiveness of the live vaccine in children.

107 was taken to ensure that both stability and lack of effector function was achieved with a minimum nu

108 Because of the lack of efficacious antagonists, the field has relied on

109 ity and mortality in patients because of the lack of efficacious treatments targeting renal manifesta

110 Rituximab's lack of efficacy could be due to a considerable placebo

111 The lack of efficacy of verubecestat in mild-to-moderate AD

112 velopment or recently abandoned because of a lack of efficacy or intolerable side effects.

113 cally were unsuccessful because of toxicity, lack of efficacy, or both.

114 subunits that would otherwise suffer from a lack of efficiency.

115 turbations are unknown, especially given the lack of efficient dynamical vegetation models to evaluat

116 The lack of EFhd2 reduced extracellular dopamine levels in t

117 ng remains less well explored because of the lack of enabling technology.

118 igen-specific cytotoxicity and near-complete lack of endogenous TCR Vbeta expression, consistent with

119 have been set up to address this, there is a lack of evaluation of their effectiveness.

120 Beyond the personal factors, there is a lack of evidence on how environmental stimulation influe

121 However, due to the lack of evolutionary conservation amongst diverse viruse

122 arises largely from obesity, poor diet, and lack of exercise, but it also involves genetic predispos

123 Lack of experimental tools that predict therapy response

124 ehavioural phenotypes have been impeded by a lack of experimental tools.

125 in attenuation of cocaine CPP extinction and lack of extinction-dependent changes in hippocampal PSD

126 tics (eccentric hilum, longitudinal fissure, lack of fissure branching, fissure ratio, and maximum gr

127 However, there is a lack of focal IL-18R expression in their terminal field.

128 Lack of full concordance of these datasets has illustrat

129 either FPN1 p.A77D, p.G80S, and p.Val162del lack-of-function or p.A69T gain-of-function mutations.

130 limitations in the number of samples and the lack of functional analysis to examine the effect of the

131 tudies are limited in cell resolution by the lack of functional annotations from difficult-to-charact

132 ly however, despite these severe features, a lack of functional ATM is still compatible with early li

133 The lack of functional improvement post-TAVR was predicted b

134 The lack of functional peri-implant epithelial sealing with

135 However, the lack of fundamental understanding of the reaction mechan

136 because of a final noninfectious etiology or lack of further follow-up or details regarding the antib

137 The lack of GABARAPs reduced Arf1 activation, which led to f

138 as been underexplored, mainly because of the lack of general synthetic strategies leading to sophisti

139 phenomena in mango fruit are limited by the lack of genome-scale data.

140 Among the Asn(297) mutants that result in lack of glycosylation and thus loss of effector function

141 The study of Tspan5 has been limited by the lack of good antibodies.

142 dictable patterns of behavior and a relative lack of habituation among patients with bipolar disorder

143 Due to a lack of high throughput glycan sequencing software, glyc

144 partly undeveloped, which accounts for their lack of high-frequency sensitivity.

145 is population has been increasing, despite a lack of high-quality evidence to demonstrate their effic

146 A major limitation of this study is the lack of histopathologic proof in most patients.

147 rsity can be explained by a combination of a lack of homologous immunity, frequent reinfections, weak

148 ntiviral development is difficult due to the lack of homology to other proteins and high-resolution s

149 impediment to testing ASD hypotheses is the lack of human cell models.

150 Limitations of this study include the lack of identification of optimal risk thresholds, as th

151 yet prominent phenotype associated with the lack of IL-1R signaling in mice and support further inve

152 Our results suggest that the lack of immune activation in RESTV-infected MDMs contrib

153 size, high binding affinity, good stability, lack of immunogenicity, and easy synthesis, aptamer GR-3

154 reatment delay and residual symptoms and the lack of improvement in treatment delay during the study

155 Currently, there is a lack of in vivo screening technologies for the discovery

156 this has often been hampered by the relative lack of information about key free-living species.

157 applied to commercial roasted coffees due to lack of information on roasting conditions.

158 There is a lack of insight into the relationships between violent i

159 This knowledge gap represents a lack of insight into the shaping of immune repertoire di

160 consensus on optimal strategies, due to the lack of institution-level studies of resuscitation pract

161 he FXR and G3BP protein families, and only a lack of interaction with both protein families strongly

162 Moreover, growth experiments showed that the lack of interface add-ons can lead to physiologically ha

163 tribute to the ACh binding site, whereas the lack of interface specificity indicates that interaction

164 ociated with carrier status is hampered by a lack of knowledge about ciHHV-6 genomes.

165 Lack of knowledge about effective primary care nursing r

166 However, there is a lack of knowledge about fecal microbiome composition in

167 We have addressed the lack of knowledge about posttranscriptional contribution

168 of these vaccines are in clinical trials, a lack of knowledge about the molecular basis that governs

169 However, there is a lack of knowledge as to which drug pharmacokinetic (PK)

170 eting of CXCR2 is threatened by our relative lack of knowledge of its precise in vivo mode of action.

171 ment of new therapies are still limited by a lack of knowledge of the functions and pathobiological m

172 plex oligosaccharides is often hindered by a lack of knowledge on the reactivity and selectivity of t

173 quired bacterial drug resistance, there is a lack of knowledge on their selectivity and activity mech

174 However, the lack of laboratory data for Earth's most abundant minera

175 he type of maternal infection as well as the lack of large-scale neonatal screening tools.

176 Skepticism abounds because of the lack of level 1 evidence.

177 t in crystalline semiconductors owing to the lack of long-range order and high defect density.

178 mol.kg(-1).d(-1), SC, at a dose selected for lack of long-term hypotensive effects at baseline).

179 So far, the lack of low-damping, magnetostrictive ferrite films has

180 e have been limited to fungal systems due to lack of mammalian genome-wide deletion collections.

181 ctivity of these neurons are hindered by the lack of markers to define their molecular identities and

182 Lack of melanization in both lineages was associated wit

183 n from drug candidate to successful use is a lack of model systems that accurately recapitulate norma

184 Currently there is a lack of models able to describe the thermodynamic stabil

185 lic liver diseases have been hampered by the lack of models.

186 they are photoprotective, in part due to the lack of mutants.

187 d complex I mitochondrial respiration due to lack of NADH for the electron transport chain.

188 The lack of new antifungal compounds with unique mechanisms

189 perior sensitivity, prolonged stability, and lack of non-specific sensor fouling may enable long-term

190 therapy paradigms is challenged in part by a lack of objective tools available to researchers for sys

191 ealth, malnutrition, waterborne illness, and lack of obstetric care.

192 Lack of ORF148 or ORF25 causes attenuation in vivo to a

193 dants may change with climate and owing to a lack of palaeo-records with which to constrain levels of

194 ompounds remains unidentified because of the lack of parent ion preservation.

195 Age and lack of past alcoholism treatments were independently as

196 The lack of PDE12 results in a spurious polyadenylation of t

197 y arterial hypertension (PAH) is hampered by lack of pediatric clinical trials.

198 , as a result of the experimental protocol's lack of perfect specificity.

199 by LAT-deficient mice, which show a complete lack of peripheral T cells.

200 nging which is at least partially due to the lack of persistent and homogeneous severe weather observ

201 cription of several genes is affected by the lack of Poleta, and that Poleta is enriched over activel

202 is precision has been limited because of the lack of polymerization techniques for conventional polym

203 and the generation of ectopic neurites; the lack of potential sites for polyamination and polyglutam

204 lues (PPVs) and false-positive rates, with a lack of precision in accuracy estimates (sensitivity ran

205 is because of their inherent flexibility and lack of predictable structure.

206 ajor challenge to TB drug development is the lack of predictive pre-clinical tools.

207 ude the exclusivity of study sites to India, lack of prior HIV/HCV diagnosis confirmation with clinic

208 Given the lack of prior research on these outcomes and stress, res

209 [VLCFAs] or branched-chain fatty acids) and lack of products (like bile acids or plasmalogens), many

210 The lack of prospective randomized clinical trials demonstra

211 lly meets target levels; however, there is a lack of protected areas within the Canadian Arctic where

212 One obstacle has been the lack of quantitative data defining exactly when cell dea

213 mental challenge in synthetic biology is the lack of quantitative tools that accurately describe and

214 applications to study the brain has been the lack of radiotracers that can identify and measure speci

215 faithfully replicate prion diseases and the lack of rapid, sensitive biological screening systems.

216 However, there is a lack of real-world data to support this estimate.

217 is a unique genetic environment defined by a lack of recombination and male-limited inheritance.

218 Despite the lack of recovery from metformin-induced impairment of mi

219 ulation of sleep-wake homeostasis, including lack of recovery sleep and impaired behavioral adjustmen

220 However, lack of refractive index information for commonly encoun

221 Here, we show that the lack of regeneration of these populations began ca. 165

222 on of a totally implantable hearing aid is a lack of reliable implantable microphone.

223 of invasive diffuse-type gastric cancer and lack of reliable surveillance options.

224 ver, they have been little explored due to a lack of reliable synthetic access.

225 ut its clinical role has been limited by its lack of reproducibility, its lack of a clear normal valu

226 lations (fixation index = 0.026), suggesting lack of reproductive isolation across the ocean.

227 The lack of research to characterize cardiovascular disease

228 g distance gene flow, genome properties, and lack of research.

229 n in patients with late onset epilepsies and lack of response to sodium channel blockers.

230 disease, persistence of inflammation, and a lack of response to therapy.

231 Elevated GDF-15 correlates with lack of reverse remodeling and increased mortality after

232 ide-products and confirmed the stability and lack of reversibility of the boronate/thiosemicarbazone

233 assessing the impact of these changes is the lack of robust baseline information on the biological co

234 rial design is challenging, due in part to a lack of robust biomarkers with predictive value, some op

235 Rpl10l expression compensates for the lack of Rpl10, which exhibits a broad expression pattern

236 o HNO2, but not to NO2(-), combined with the lack of S-nitrosation during anoxia alone or by NO2(-) d

237 -prion therapeutics have been impeded by the lack of screening models that faithfully replicate prion

238 cellular senescence has been hindered by the lack of senescence-specific markers.

239 uisition speed, poor spatial resolution, and lack of sensitivity.

240 There is a lack of simple and validated severity assessments that a

241 g of RNA localization has been hindered by a lack of simple, high-throughput methods for mapping the

242 in AIS remains controversy because there is lack of site-matched control for detailed analysis on bo

243 However, their development is limited by the lack of solid electrolyte materials that can reach the p

244 ormed an injury study to investigate whether lack of SPARC would compromise the ability to repair mus

245 These variously suffer from lack of specificity, high cell loss, use of labels, and

246 due to technical issues associated with the lack of stability and high cost of the biological recogn

247 f cell walls, subcellular organelles and the lack of stable cell lines have prevented routine applica

248 poorly described and understood, due to the lack of stable experimental systems and design strategie

249 Furthermore, a lack of standardisation across current approaches and sp

250 cturing of biomedical devices, including the lack of standardization in the production of the graphen

251 ver, the number of published models, and the lack of standardization, make the comparison of ion chan

252 However, lack of standardized algorithm definitions and image pro

253 The lack of statistically robust relationships between IEPOX

254 However, there remains a lack of statistically sound frameworks to model the unde

255 To study how multistage killing and a lack of steady state influence the functional response,

256 There is a lack of strong evidence and a requirement for further re

257 equirement for a ketogenic diet, the assumed lack of structural brain defects, and the potential exis

258 Lack of structural information has precluded elucidation

259 This lack of structural tools is identified as a crucial bott

260 Unfortunately, the lack of structure in radiologic reports limits the abili

261 lements but rather suggested that an overall lack of structure was an important feature for IRES acti

262 r purely theoretical pathogen systems, and a lack of studies occurring at the wildlife-public health

263 n of electrons across each GPNJ, so that the lack of substantial overlap between transmission lobes a

264 arker and pathway discovery, in spite of the lack of successful applications to human disease.

265 ategies have been unsuccessful, because of a lack of suitable screening methodologies and well-define

266 ector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microe

267 roviding an incorrect diastereomer or due to lack of synthetic efficiency.

268 However, there yet remains a lack of systematic studies of energetic proton induced c

269 therapeutic approaches has been limited by a lack of target antigens that discriminate malignant from

270 ecline in the host's clinical status and the lack of targeted therapies for TSS emphasize the need to

271 Moreover, we contend that the lack of taxonomic granularity and use of vague generic n

272 also demonstrate loss of LAT expression and lack of TCR signaling restoration in LAT-deficient cell

273 cell level has been difficult because of the lack of techniques for multimodal profiling of individua

274 The relative lack of tetra- and penta-chlorinated PCDD/Fs suggested t

275 all short of being subject specific due to a lack of the necessary clinical data.

276 nisms by which one input compensates for the lack of the other.

277 The lack of the s(2) modification also slows down the rearra

278 This clearly demonstrates the lack of the skyrmion topological protection in finite-si

279 which is only partially accounted for by the lack of the WH2 domain.

280 Although there has been no lack of theoretical studies on quasicrystal growth, ther

281 posed of necrotic material, explaining their lack of therapeutic response.

282 Overall, our results indicated a lack of thermal local adaptation, but a presence of plas

283 tion to clinical practice is hindered by the lack of thorough preclinical testing using representativ

284 e in KF neurons correlates with the relative lack of tolerance to the respiratory depressant effect o

285 ent's immune response to FVIII, because of a lack of tolerance, leading to the formation of inhibitor

286 apeutic intervention has been limited by the lack of tool compounds that can specifically modulate th

287 lagged behind their identification due to a lack of tools for the high-throughput analysis of RNA-RN

288 ent was owing to poor treatment adherence or lack of treatment effect.

289 Here we report that lack of Trex2 results in the accumulation of DNA fragmen

290 Lack of TSP-1 prevented lesion formation in hyperglycemi

291 ence from the fossil record is hampered by a lack of unambiguous biomarkers.

292 A lack of understanding about the causes of this condition

293 er, evidence for microrefugia is hindered by lack of understanding of how rates of warming vary acros

294 mber of genes duplicated in Trisomy 21 and a lack of understanding of the effect of disease pathology

295 A lack of understanding of the mechanisms underlying these

296 This gap in knowledge stems from a lack of understanding of the physics of surface structur

297 Their use, however, remains limited by a lack of understanding of the processes that determine th

298 Because of the lack of understanding, the complex mechanisms involved i

299 ion into early-phase patient trials, but the lack of validated biomarkers of disease progression pres

300 increase after initiation of ART heralded a lack of virologic or clinical response, and hence their