ライフサイエンスコーパス: lacrimal

1 del of aqueous-deficient dry eye produced by lacrimal ablation, topical administration of 0.1 nmol CF

2 basal tear protein secretion in cultured rat lacrimal acinar cells and proliferation of subconfluent

3 y were (1) to develop a procedure to culture lacrimal acinar cells from monkey and (2) to determine t

4 ated, because a system for culturing primate lacrimal acinar cells had not been established.

5 Lacrimal acinar cells immunoreacted with GCDFP-15 and CK

6 motes basal tear peroxidase secretion by rat lacrimal acinar cells in vitro.

7 Our data demonstrate that lacrimal acinar cells lacking Orai1 do not exhibit SOCE

8 Successful culture of monkey lacrimal acinar cells showed that, among the prevalent t

9 The expression of TRPP channels in lacrimal acinar cells suggests a functional role of the

10 (IP(3)Rs), and ryanodine receptors (RyRs) in lacrimal acinar cells, however, little is known regardin

11 Lacritin, a glycoprotein secreted from lacrimal acinar cells, may function as an autocrine fact

12 Sox9 is required for the development of the lacrimal and harderian glands and contributes to the for

13 ium as early as E11.5 and is detected in the lacrimal and harderian glands as they form.

14 Lacrimal and Harderian glands, which are derived from th

15 Lubricin messenger RNA is also present in lacrimal and meibomian glands, as well as in a number of

16 lopment of new strategies to maintain normal lacrimal and salivary gland function in patients with SS

17 ant improvement in the objective measures of lacrimal and salivary gland function.

18 Lacrimal and salivary gland PAs and Ca-ex-PAs have simil

19 me is a chronic autoimmune disease affecting lacrimal and salivary glands that often is accompanied b

20 The autoantigen Klk1b22, isolated from the lacrimal and salivary glands, readily induced Sjogren's

21 function due to immune cell infiltration in lacrimal and salivary glands.

22 erized by immune-mediated destruction of the lacrimal and salivary glands.

23 crine glands leading to chronically impaired lacrimal and salivary secretion.

24 ts showed persistent uptake in the salivary, lacrimal, and parotid glands.

25 Eight patients with an intact lacrimal artery had significantly better outcomes for su

26 patients (group 2) who had an absence of the lacrimal artery or deviated from the treatment protocol

27 An intact lacrimal artery, no disruption of bone barrier or tumor

28 that optimal surgical management of chronic lacrimal canaliculitis allows for both accurate microbio

29 st documented case of A. aphrophilus chronic lacrimal canaliculitis illustrates that optimal surgical

30 ral chronic epiphora associated with chronic lacrimal canaliculitis resistant to prolonged topical an

31 The "wedge sign" frequency is assessed in lacrimal carcinoma, lacrimal lymphoma, or dacryoadenitis

32 tein secretion, suggesting that a decline in lacrimal cell function contributes to dry eye.

33 Previously, in single lacrimal cells isolated from lacrimal glands, we demonst

34 ting a hereditary component in patients with lacrimal disorders is helpful in determining the underly

35 cian in understanding and categorizing those lacrimal disorders with a hereditary component.

36 mpletion of chemotherapy, patients underwent lacrimal drainage evaluation by computed tomographic dac

37 Tear film impairment (aqueous and lipid) and lacrimal drainage obstruction should be considered in su

38 t was an anomaly of the meibomian glands and lacrimal drainage system defects.

39 dies that describe the efficacy or safety of lacrimal drainage system plugs.

40 blish a nomenclature for each segment of the lacrimal duct system and provide evidence that ducts pla

41 The lacrimal duct system was divided into six segments on th

42 d granulation tissue in the larynx, urethra, lacrimal duct, and external auditory canal.

43 er blood flow changes around the ipsilateral lacrimal duct, superior salivatory nucleus stimulation e

44 The lack of knowledge regarding the lacrimal ducts was so profound that a precise nomenclatu

45 elatively little attention being paid to the lacrimal ducts.

46 unction (11% prevalence) was associated with lacrimal dysfunction (P = 0.010) and xerostomia with xer

47 ent (erythema and sclerosis, skin symptoms), lacrimal dysfunction (Schirmer's tear test, xerophthalmi

48 Encountering a patient with lacrimal dysgenesis or agenesis is not an uncommon occur

49 eaction when cocultured with purified rabbit lacrimal epithelial cells, induce a Sjogren's-like autoi

50 ed with infiltrating leukocytes and not with lacrimal epithelial cells.

51 ear volume and tear composition (osmolarity, lacrimal factors, inflammatory mediators, growth and dif

52 al role of the proteins in the regulation of lacrimal fluid secretion under physiological and disease

53 In this study, the lacrimal function unit (LFU) and the stressed wound-heal

54 n produce a significant deterioration of the lacrimal function unit in female SS dry eye patients.

55 Genes for control of lacrimal function, including cholinergic, adrenergic, va

56 pressed genes, 9 were of direct relevance to lacrimal function.

57 athology of DED involves inflammation of the lacrimal functional unit (LFU), comprising the cornea, c

58 Clinical evaluation showed lacrimal functional unit impairment after the desiccatin

59 The lacrimal gland (28%), conjunctiva (28%), and orbit (28%)

60 g from the orbit (19), conjunctivae (18) and lacrimal gland (6).

61 The lacrimal gland (LG) delivers defensive and metabolic fac

62 The lacrimal gland (LG) develops through branching morphogen

63 Bilateral lacrimal gland (LG) disease is a unique presentation tha

64 To describe the involvement of the lacrimal gland (LG) in blepharophimosis-ptosis-epicanthu

65 Lacrimal gland (LG) morphogenesis and repair are regulat

66 us, and evaluate its effects on the inflamed lacrimal gland (LG) of non-obese diabetic mouse (NOD), a

67 in the parasympathetic neural stimulation of lacrimal gland (LG) secretion.

68 ia receptor-mediated transcytosis across the lacrimal gland (LG), which produces the bulk of human te

69 progenitor cells in the uninjured, adult rat lacrimal gland (LG).

70 the eyelids (n = 53 [82%]), followed by the lacrimal gland (n = 5), conjunctiva (n = 4), and eyebrow

71 Lacrimal gland abscess or dacryoadenitis was the present

72 Fourteen patients with primary lacrimal gland ACC were included.

73 Lacrimal gland ACCs are frequently positive for the MYB-

74 Our findings show that lacrimal gland ACCs are genetically and clinically simil

75 Dysfunction of lacrimal gland acinar cells can ultimately result in ocu

76 hexosaminidase secretion from primary rabbit lacrimal gland acinar cells.

77 Rat lacrimal gland acini were incubated with H89, an inhibit

78 Rat lacrimal gland acini were isolated by collagenase digest

79 Rat lacrimal gland acini were isolated by collagenase digest

80 signaling components of this pathway in rat lacrimal gland acini.

81 t (LFU), comprising the cornea, conjunctiva, lacrimal gland and interconnecting innervation.

82 (typically the lateral) and, less often, the lacrimal gland and is often mild when it arises during o

83 but not Pax6(PE/PE) mice, developed stunted lacrimal gland and lens hypoplasia which was significant

84 Lacrt has prosecretory activity in the lacrimal gland and mitogenic activity at the corneal epi

85 regulator (aire)-deficient mice, we assessed lacrimal gland and ocular surface immunopathology by qua

86 Lymphocytic infiltration of the lacrimal gland and ocular surface in autoimmune diseases

87 TLR2 and 5 were upregulated in lacrimal gland and overall, there was a corresponding ch

88 an essential transcription factor for lens, lacrimal gland and pancreas development.

89 whether these cells can be isolated from the lacrimal gland and propagated in vitro.

90 ESP22 is secreted from the lacrimal gland and released into tears of 2- to 3-week-o

91 vated by adenosine triphosphate (ATP) in rat lacrimal gland and to determine their role in protein se

92 X(7) purinergic receptors are present in rat lacrimal gland and when stimulated increase [Ca(2+)](i),

93 pproach, however, we have identified a novel lacrimal gland autoantigen, odorant binding protein 1a,

94 to investigate the pathogenic mechanisms in lacrimal gland autoimmunity and associated ocular surfac

95 es were reviewed and microscopic sections of lacrimal gland biopsy samples were critically re-evaluat

96 , downstream of FGF signaling, in regulating lacrimal gland branching and differentiation.

97 on, we demonstrate that Shp2 is required for lacrimal gland budding, lens cell proliferation, surviva

98 P2X(7) receptors were present in the lacrimal gland by RT-PCR and Western blot analysis.

99 ) and P2X(6)receptors were identified in the lacrimal gland by RT-PCR, Western blot, and immunofluore

100 ession in sarcoidosis involving the orbit or lacrimal gland can be distinguished from gene expression

101 Lacrimal gland carcinoma can form a triangle of tissue b

102 It is significantly more common in lacrimal gland carcinoma compared with dacryoadenitis an

103 aging for 116 patients was reviewed: 39 with lacrimal gland carcinoma, 37 with lymphoma, and 40 with

104 The "wedge sign" is most common in lacrimal gland carcinoma, but can occur in patients with

105 mposed of rabbit conjunctival epithelium and lacrimal gland cell spheroids, and recapitulates the aqu

106 In lacrimal gland cells, the activation of M3AChRs stimulat

107 ioma (n = 4; 10%), melanocytoma (n = 3; 8%), lacrimal gland choristoma (n = 2; 5%), gliosis (n = 1; 3

108 The lacrimal gland contains stem/progenitor cells capable of

109 genetic rescue experiments in which the Ugdh lacrimal gland defect is ameliorated by constitutive Ras

110 tive FGF receptor only partially rescued the lacrimal gland defects in Sox9 heterozygotes, suggesting

111 To address if lacrimal gland development and FGF signaling depends on

112 Therefore, Fgf10-Fgfr2b signaling during lacrimal gland development is sensitive to the content o

113 We further show that lacrimal gland development requires the mesenchymal expr

114 ogether, our data reveal crucial features of lacrimal gland development that have broad implications

115 nly for modulating Ras signaling in lens and lacrimal gland development, but also for RTK signaling i

116 st;Hs6st double mutants completely abolished lacrimal gland development, suggesting that both 2-O and

117 e main downstream target of Shp2 in lens and lacrimal gland development.

118 nd epithelial lineage dynamics that underlie lacrimal gland development.

119 ellular matrix components during early stage lacrimal gland development.

120 The cause of bilateral lacrimal gland disease most commonly was inflammatory, f

121 Lacrimal gland ductal cysts (dacryops) are uncommon, occ

122 infective debris (1 case) from the affected lacrimal gland ductule--typically the most inferolateral

123 Infective lacrimal gland ductulitis, commonly from Actinomyces inf

124 disease, (2) salivary gland dysfunction and lacrimal gland dysfunction, and (3) limited mouth-openin

125 in ATD and Sjogren syndrome, conditions with lacrimal gland dysfunction.

126 gland involvement, orbital pseudotumor, and lacrimal gland enlargement.

127 the co-receptors for Fgf10 signaling in the lacrimal gland epithelium, but their function in the Fgf

128 or budding morphogenesis in the presumptive lacrimal gland epithelium.

129 c scopolamine, or by performing extraorbital lacrimal gland excision.

130 otype but led to significant improvements in lacrimal gland exocrinopathy and tear secretion.

131 portance of heparan sulfate 6-O sulfation in lacrimal gland FGF signaling.

132 fibroblasts were elevated in cGVHD-affected lacrimal gland fibroblasts and (2) that they could be re

133 absence of recent upper respiratory illness, lacrimal gland focus, multiple orbital abscesses, and la

134 2283 genes) were significantly lower in the lacrimal gland for patients with sarcoidosis.

135 l types and lineage relationships that drive lacrimal gland formation are unclear.

136 other orbital inflammatory conditions in the lacrimal gland fossa.

137 We show that the lacrimal gland from its earliest developmental stages is

138 molecular signalling processes that control lacrimal gland function will give insight into correctiv

139 The Hs6st mutants exhibited significant lacrimal gland hypoplasia and a strong genetic interacti

140 IL-1beta activated ERK in the lacrimal gland in vitro and in vivo, and this effect was

141 te complex on the cell surface and prevented lacrimal gland induction by Fgf10 in explant cultures.

142 ts demonstrate that mesenchymal GAG controls lacrimal gland induction by restricting the diffusion of

143 se occurs in the setting of conjunctival and lacrimal gland inflammation, potentially mediated by the

144 was to determine the mechanisms involved in lacrimal gland injury and repair.

145 R(-/-)) had the same submandibular gland and lacrimal gland injury as did the IL14alphaTG mice, but t

146 Lacrimal gland injury was induced by injection of interl

147 It was recently reported that repair of the lacrimal gland involved the mobilization of mesenchymal

148 Lacrimal gland involvement in granulomatosis with polyan

149 inical and imaging features of patients with lacrimal gland involvement secondary to GPA and to compa

150 nd to have orbital inflammatory disease with lacrimal gland involvement, of whom 7 had a final diagno

151 The tear-producing lacrimal gland is a tubular organ that protects and lubr

152 Ongoing studies demonstrate that the murine lacrimal gland is capable of repair after experimentally

153 Previously, it was reported that the murine lacrimal gland is capable of repair after experimentally

154 The lacrimal gland is primarily responsible for the aqueous

155 , and secretion from the acinar cells of the lacrimal gland is regulated by both cholinergic and adre

156 egenerative potential in a rabbit model with lacrimal gland main excretory duct ligation-induced inju

157 erwent debulking surgery of the inflammatory lacrimal gland mass for diagnostic and therapeutic reaso

158 ot attenuate lymphocytic infiltration of the lacrimal gland or eye, it significantly reduced ocular s

159 A total of 36 tumors from 32 patients with lacrimal gland PA or Ca-ex-PA were included in the study

160 tance for disease progression in a subset of lacrimal gland PAs.

161 oma and generally indicates life-threatening lacrimal gland pathology that requires urgent biopsy.

162 w of images from patients with biopsy-proven lacrimal gland pathology.

163 Carbachol increased ATP release from lacrimal gland pieces but not from acini.

164 Biophysical properties of lacrimal gland polycystin-2 channels were similar to tho

165 The lacrimal gland possesses many features that make it an e

166 Lacrimal gland progenitor cells isolated from ligated ti

167 Isolated lacrimal gland progenitor cells were tested and characte

168 Lacrimal gland protein secretion was measured using a sp

169 An enlarged salivary gland or lacrimal gland raises a wide differential diagnosis that

170 tear protein, it promotes basal tearing and lacrimal gland secretion.

171 (ERK) in inflammation-induced inhibition of lacrimal gland secretion.

172 ants (e.g., urinary pheromones, extraorbital lacrimal gland secretions, major histocompatibility comp

173 ut ((-/-)) mice have impaired ocular surface-lacrimal gland signaling, rendering them susceptible to

174 e a critical role for Orai1-mediated SOCE in lacrimal gland signalling and function.

175 The results provide further insights into lacrimal gland stem/progenitor cell physiology and their

176 The existence of lacrimal gland stem/progenitor cells was proposed in sev

177 iple pustules/abscesses in the region of the lacrimal gland that were expressing purulent fluid into

178 ryops) are uncommon, occurring anywhere that lacrimal gland tissue is present.

179 Studies were performed in adult lacrimal gland tissue of Swiss-Webster mice.

180 fforts, the molecular and cellular events in lacrimal gland tissues initiating inflammatory responses

181 und that EMT is induced during repair of the lacrimal gland to generate MSCs to initiate repair, and

182 ied the expression of MYB-NFIB in 19 non-ACC lacrimal gland tumors.

183 notype, in which the exorbital branch of the lacrimal gland was absent in most cases.

184 The major lacrimal gland was involved in 13 lesions; 2 lesions aro

185 e were noted to have significantly increased lacrimal gland weight, with enlarged, carbohydrate-rich,

186 Acinar cells from monkey lacrimal gland were cultured and characterized.

187 Acini from rat lacrimal gland were isolated by collagenase digestion.

188 Caspase 1 and ERK activities in the lacrimal gland were measured by immunohistochemistry, We

189 ment of one of more salivary gland(s) and/or lacrimal gland(s).

190 idosis (7 in adipose tissue; 5 affecting the lacrimal gland) as well as comparable tissue from 6 heal

191 Idiopathic inflammatory tumor of the lacrimal gland, also called idiopathic dacryoadenitis, g

192 re equally noted to involve the conjunctiva, lacrimal gland, and orbit.

193 cells in the inflammatory infiltrates of the lacrimal gland, and the presence of anti-Sjogren's syndr

194 inflammatory CD4(+) T cells detected in the lacrimal gland, as well as those in the periphery of old

195 increased apoptosis and deterioration in the lacrimal gland, associated dysfunction, and development

196 In the lacrimal gland, branching morphogenesis depends on the i

197 Human fibroblasts were isolated from the lacrimal gland, cornea, and Tenon's capsule and treated

198 eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphoma) were includ

199 Lacritin protein is highly expressed in the lacrimal gland, secreted into tear fluid, and detected o

200 Secretory function also increased in the lacrimal gland, suggesting this local therapy could trea

201 rkers between the developing mouse and human lacrimal gland, supporting the use of mice to understand

202 voked macrophage infiltration to the eye and lacrimal gland, where they played a functional role in d

203 e formation of secretory acinar lobes in the lacrimal gland.

204 on were determined at the ocular surface and lacrimal gland.

205 nic inflammation in the underlying stroma or lacrimal gland.

206 ptors P2X(1-4) and P2X(6) are present in the lacrimal gland.

207 olycystin-2L2) were expressed in adult mouse lacrimal gland.

208 that P2X(7)receptors were functional in the lacrimal gland.

209 ion of interleukin (IL)-1 into the exorbital lacrimal gland.

210 es (Hs2st, Hs6st1, and Hs6st2) in developing lacrimal gland.

211 esenchymal transition (EMT) in repair of the lacrimal gland.

212 thelium, but not in the CN epithelium or the lacrimal gland.

213 gher uptake in kidneys, urinary bladder, and lacrimal gland.

214 in AL2 mRNA was detected only in male rabbit lacrimal gland.

215 2, BL, CL, and CL2 were detected only in the lacrimal gland.

216 of unipotent KRT5(+) epithelial cells in the lacrimal gland.

217 f Tregs and CD4(+) IFN-gamma(+) cells in the lacrimal gland.

218 mediated assembly to form a depot inside the lacrimal gland.

219 g robustly rescue the lens proliferation and lacrimal-gland-budding defects in the Shp2 mutants.

220 me-related immunopathological changes in the lacrimal glands (LGs) of CD25KO mice, we examined LGs of

221 Lacrimal glands (LGs) of male NOD mice, a model of Sjogr

222 Paraffin-embedded lacrimal glands (LGs) were stained with hematoxylin and

223 lands of Wolfring is similar to that of main lacrimal glands and are consistent with secretion electr

224 oimmune disease starting in the salivary and lacrimal glands and continuing to involve the lungs and

225 The accessory lacrimal glands are assumed to contribute to the product

226 The results of our study indicate that lacrimal glands are capable of tissue repair after duct

227 ounds localize to the parotid, salivary, and lacrimal glands as well as to the kidney, leading to dos

228 expression profiles of C57BL/6.NOD-Aec1Aec2 lacrimal glands before, or concomitant with, the first a

229 Murine lacrimal glands contain mesenchymal stem cells that seem

230 l, T-cell infiltration into the salivary and lacrimal glands could be successfully visualized.

231 Klf5CN lacrimal glands displayed increased vasculature and larg

232 Cultured MSCs isolated from injured lacrimal glands expressed Snai1 and vimentin alongside n

233 multifactorial chronic disorder in which the lacrimal glands fail to produce enough tears to maintain

234 Exorbital lacrimal glands from male Sprague-Dawley rats were divid

235 Exorbital lacrimal glands from male Sprague-Dawley rats were divid

236 Lacrimal glands function to produce an aqueous layer, or

237 gene expression profiles were generated for lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice 4 to 20 wee

238 s infiltrate the corneal stroma, limbus, and lacrimal glands of diseased mice.

239 tial biomarkers of impending autoimmunity in lacrimal glands of SjS-prone mice.

240 ioration of the autonomic innervation of the lacrimal glands rather than an impaired corneal innervat

241 Lacrimal glands regulate the production and secretion of

242 Lacrimal glands secrete proteins, electrolytes and water

243 The ligation-injured lacrimal glands temporarily decreased in weight and had

244 cterize the role of Orai1 in the function of lacrimal glands using a mouse model in which the gene fo

245 : 1) initial injury to the submandibular and lacrimal glands via an environmental insult and LTalpha;

246 Acinar cells from monkey lacrimal glands were cultured with or without tumor necr

247 ted acinar epithelial monolayers from rabbit lacrimal glands were exposed to varying concentrations o

248 Two and half days after injection, the lacrimal glands were removed and used to prepare explant

249 Rat lacrimal glands were subjected to collagenase digestion,

250 tissue PMN population in the corneal limbus, lacrimal glands, and cervical lymph nodes of healthy mal

251 low, occurred mainly around the salivary and lacrimal glands, and could easily be corrected.

252 MECs can be isolated from rat lacrimal glands, and they express P2X(7), P2Y(1), P2Y(11

253 to mononuclear infiltration of salivary and lacrimal glands, as well as to expansion of bronchial ly

254 usly, in single lacrimal cells isolated from lacrimal glands, we demonstrated that muscarinic recepto

255 uclear cell infiltration in the salivary and lacrimal glands.

256 alpha1, collagen type IIIalpha1 and NF-kB in lacrimal glands.

257 ltration of inflammatory/immune cells in the lacrimal glands.

258 utoimmune disease affecting the salivary and lacrimal glands.

259 from IL-1-injected, but not saline-injected, lacrimal glands.

260 autoimmune diseases of ovary, prostate, and lacrimal glands.

261 surface epithelia and on fluid secretion by lacrimal glands.

262 so known as lipophilins, are found in rabbit lacrimal glands.

263 njunctiva, cornea, and tears produced by the lacrimal glands.

264 y excessive inflammation and fibrosis in the lacrimal glands.

265 immune disease mainly affecting salivary and lacrimal glands.

266 conjunctival epithelium, eyelids and ocular [lacrimal, harderian (HG), and meibomian (MG)] glands and

267 Murine lacrimal, harderian and meibomian glands develop from th

268 Exclusion criteria included evidence of lacrimal hypersecretion, eyelid malposition, and punctal

269 Lacrimal immunohistopathology has diverse clinical prese

270 dacryoadenitis, when administered via intra-lacrimal injection.

271 of orbital GPA, especially in patients with lacrimal involvement as the initial presentation, can be

272 e of a patent ostium and 100% were patent on lacrimal irrigation.

273 y affects exocrine glands--mainly labial and lacrimal--leading to complaints of dry mouth and eyes.

274 frequency is assessed in lacrimal carcinoma, lacrimal lymphoma, or dacryoadenitis.

275 pendages: skin, teeth, and nails--as well as lacrimal, mammary, salivary, sebaceous and sweat glands.

276 Lacrimal meniscus height, Schirmer test I, presence of s

277 cluded that the modified preserved nasal and lacrimal mucosal flap technique in EES-DCR for treating

278 Modified preserved nasal and lacrimal mucosal flap technique in EES-DCR was applied i

279 e we describe a modified preserved nasal and lacrimal mucosal flap technique in endonasal endoscopic

280 (OCT) and to identify characteristics of the lacrimal punctum in patients who benefit from punctoplas

281 Lacrimal punctum infrared and OCT imaging may be helpful

282 mine the application of imaging the stenotic lacrimal punctum with infrared photographs and optical c

283 tion of exocrine glands, mainly salivary and lacrimal, resulting in oral and ocular dryness, although

284 n to receive either percutaneous drainage of lacrimal sac abscess followed by EN-DCR after the acute

285 in the setting of acute dacryocystitis with lacrimal sac abscess have not been well studied.

286 ary treatment after percutaneous drainage of lacrimal sac abscess in acute dacryocystitis.

287 le participants had acute dacryocystitis and lacrimal sac abscess presenting within 2 weeks of onset,

288 Primary EN-DCR in acute dacryocystitis with lacrimal sac abscess results in faster resolution compar

289 obstruction to include DCR revisions, acute lacrimal sac abscesses, nasolacrimal duct obstructions i

290 Pharmacological blockade of lacrimal secretion induced a significant CD4(+) infiltra

291 e evidence that ducts play critical roles in lacrimal secretion.

292 Culturing lacrimal secretions and concretions yielded Aggregatibac

293 Intubation with a lacrimal stent was performed in 82% of the cases at the

294 domization code was revealed as to whether a lacrimal stent was placed or not.

295 al applications, and an increasing number of lacrimal surgeons have focused on laser-assisted approac

296 yelids, hereditary disorders that affect the lacrimal system are fewer in number.

297 Inherited disorders that affect the lacrimal system are limited in number.

298 Lid and lacrimal system disorders were more common, but keratiti

299 reports of inherited disorders affecting the lacrimal system that have not been elucidated molecularl

300 lus allowing silicone tube intubation of the lacrimal system.