ライフサイエンスコーパス: lactate

1 gen) and biochemical assays (for glucose and lactate).

2 ding marked hypotension and a rise in plasma lactate.

3 with a small molecule that we identified as lactate.

4 enylboronic acid (3-APBA) with imprinting of lactate.

5 the LHA and rescued by in vivo injections of lactate.

6 during growth on glucose, and rtg3 cells on lactate.

7 he retina where photoreceptors convert it to lactate.

8 , that act sequentially to convert MG into d-lactate.

9 iral metal-organic frameworks (MOFs), Ca14(l-lactate)20(acetate)8(C2H5OH)(H2O) (MOF-1201) and Ca6(l-l

10 (acetate)8(C2H5OH)(H2O) (MOF-1201) and Ca6(l-lactate)3(acetate)9(H2O) (MOF-1203), are constructed fro

11 At steady-state, junctional transmission of lactate (a chemical base) from the spheroid core had an

12 nt effect is mediated by increased levels of lactate, a by-product of glycolytic metabolism.

13 nse of mitochondrial respiration, and led to lactate accumulation.

14 versible intracellular glucose depletion and lactate accumulation.

15 Lactate activates macrophage Gpr132 to promote the alter

16 corded oxygen consumption and assessed blood lactate after each swimming technique.

17 ficant differences are noted with respect to lactate, alanine, and CO2 production.

18 mine-dependent mitochondrial enzymes, mainly lactate, alpha-ketoglutarate, and branched chain keto-ac

19 Finally, lactate, an essential energy substrate produced by astro

20 The magnitude of both lactate and bicarbonate signals were positively correlat

21 w the rapid conversion of (13)C1-pyruvate to lactate and bicarbonate, indicating active glycolytic an

22 tility generated more pyruvate conversion to lactate and bicarbonate.

23 n glucose concentration matched to a rise in lactate and concurrently with pronounced changes in the

24 A detailed comparison of sodium, lactate and cortisol from saliva is reported, demonstrat

25 Anaerostipes species, supported by increased lactate and decreased butyrate levels.

26 de arrays designed to simultaneously monitor lactate and glucose fluctuations and ongoing neuronal ac

27 Strikingly, directly comparing lactate and glucose metabolism in vivo indicated that la

28 sis of plasma following infusion of [3-(13)C]lactate and glucose tracer.

29 r the measurement of hepatic fluxes by using lactate and glucose tracers in combination with NMR spec

30 ion reduced the flow of glucose carbons into lactate and glutamate without markedly increasing glucos

31 tive correlation was observed between sputum lactate and IL-1beta levels, and lactate content correla

32 Electrochemical microsensors for lactate and oxygen allow fast, precise and continuous lo

33 A microsensor platform for lactate and oxygen was integrated in a standard 96-well

34 ic and molecular parameters including plasma lactate and p-AMPK/AMPK, as well as Ach-mediated vascula

35 with mitochondrial disease exhibit elevated lactate and reduced uridine; in McArdle disease purine n

36 ysis, during which glucose is converted into lactate and released extracellularly.

37 ed by the carboxylate and hydroxyl groups of lactate and the carboxylate group of acetate to give a t

38 lts in lower postprandial glucose and higher lactate and triglyceride concentrations.

39 sly and selectively measure metabolite (e.g. lactate) and electrolytes (e.g. pH, sodium) together wit

40 increased glucose consumption, production of lactate, and presence of ATP.

41 lator EMRE, and aequorin, and exploiting a D-lactate- and mannitol/sucrose-based bioenergetic shunt t

42 nnels are important conduits for dissipating lactate anions from glycolytic PDAC cells.

43 cytoplasmic pH as a read-out, indicated that lactate anions permeate gap junctions faster than highly

44 rs, including bona fide human NSCLC, can use lactate as a fuel in vivo.

45 Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and f

46 us coronary intervention, and arterial blood lactate at admission >5 mmol/l.

47 " (urine isoprostane); and "tissue hypoxia" (lactate) at 0, 6, 24, and 72 hours after treatment.

48 13, I218 and Y285 and Y249-were required for lactate binding.

49 e and selective field effect transistor-type lactate biosensor.

50 Some l-lactate biosensors employ artificial electron mediators,

51 l-lactate biosensors employing l-lactate oxidase (LOx) hav

52 , systolic pressure, mean arterial pressure, lactate, bundle compliance, amount of fluid administered

53 tivity allowed discrimination of d- versus l-lactate by both high-resolution NMR and CEST.

54 ese can negatively impact the detection of l-lactate by competing with the primary electron acceptor:

55 esults suggest that expressions of LDH-A and lactate by macrophage in the tumor microenvironment are

56 ble calcium salts, calcium chloride, calcium lactate, calcium gluconate and calcium lactobionate, on

57 rculating metabolites in mice, and find that lactate can be a primary source of carbon for the TCA cy

58 s article, we demonstrate that extracellular lactate can be used to dynamically assess human T cell r

59 human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retin

60 203), are constructed from Ca(2+) ions and l-lactate [CH3CH(OH)COO(-)], where Ca(2+) ions are bridged

61 poxia in producing local angiotensin II by a lactate-chymase-dependent mechanism and highlight the im

62 umulation was observed for 12-hour values of lactate clearance (area under the curve = 0.839; 95% CI,

63 atemia (>/= 4 mmol/L), the median calculated lactate clearance at 6, 12, and 18 hours was 24.0%, 48.1

64 e vascular flow parameters and the perfusate lactate clearance were similar in both groups.

65 ted with T cell proliferation, and measuring lactate compared favorably with traditional methods for

66 thmatic patients intrinsically produced more lactate compared with cells from healthy subjects.

67 LOx) have been developed mainly to measure l-lactate concentration for clinical diagnostics, sports m

68 tate kinetics rather than initially elevated lactate concentration should be considered in assessing

69 racteristics-area under the curve of initial lactate concentration was 0.789 for the prediction of ci

70 djusting for bicarbonate less than 20 mEq/L, lactate concentration, respiratory rate greater than or

71 regional citrate anticoagulation by initial lactate concentrations and lactate kinetics.

72 ween sputum lactate and IL-1beta levels, and lactate content correlated negatively with lung function

73 Lactate content was significantly higher in sputum super

74 It is unknown whether lactate contributes to energy metabolism in living tumor

75 Significantly higher pyruvate-to-lactate conversion (lactate/pyruvate + lactate ratio) wa

76 nificant increase in HP [1-(13)C]pyruvate-to-lactate conversion, which was associated with a high den

77 tection of increased HP [1-(13)C]pyruvate-to-lactate conversion.

78 ay-1 aspartate aminotransferase (AST), day-1 lactate, day-3 bilirubin, day-3 international normalized

79 During hypoglycemia, brain lactate decreased approximately 30% below baseline in pa

80 easing concentrations of the electron donor, lactate, decreased the rate.

81 tate aminotransferase were persistently low (lactate dehydrogenase < 100 U/L, below analyzer range; a

82 ents who received D + T with baseline normal lactate dehydrogenase (5 years, 45%) and normal lactate

83 ase (34.3 +/- 16.6 vs 24.5 +/- 16.8U/L), and lactate dehydrogenase (510.8 +/- 33 vs 292.4 +/- 29).

84 ting expression of the Drosophila homolog of lactate dehydrogenase (dLdh).

85 We identified lactate dehydrogenase (LDH) as a new functional target o

86 Cellular viability, autophagy, lactate dehydrogenase (LDH) assay, and mammalian target

87 ,5-diphenyl tetrazolium bromide (MTT) assay, lactate dehydrogenase (LDH) release assay, Hoechst 33342

88 ttributed to the terminal glycolytic enzyme, lactate dehydrogenase (LDH).

89 series of pyrazole-based inhibitors of human lactate dehydrogenase (LDH).

90 rich protein II (PfHRP-II) and P. falciparum lactate dehydrogenase (PfLDH) antigens are widely deploy

91 idine-rich protein-II (HRPII) and Plasmodium lactate dehydrogenase (pLDH).

92 of a dual-band (histidine-rich protein-2/pan-lactate dehydrogenase [HRP2/pLDH]) rapid diagnostic test

93 Lactate dehydrogenase A (LDHA) has been reported to be i

94 t that phosphorylation-induced activation of lactate dehydrogenase A (LDHA), an enzyme that catalyses

95 ycolytic enzymes, with notable expression of lactate dehydrogenase A occurring in the airway epitheli

96 a targets VEGF-A, glucose transporter-1, and lactate dehydrogenase A.

97 PL flux correlated significantly with higher lactate dehydrogenase activity and mRNA expression of Ld

98 Cellular injury markers lactate dehydrogenase and aspartate aminotransferase wer

99 asured by optical imaging and by analysis of lactate dehydrogenase and caspase-cleaved cytokeratin 18

100 ucing sugars and phenolic compounds, and the lactate dehydrogenase assay was invalidated by honey oxi

101 o demonstrate that the reaction landscape of lactate dehydrogenase branches at multiple points creati

102 d be moderated by using PfHRP2/Pf-Plasmodium lactate dehydrogenase combination RDTs.

103 n and functionalized with glutaraldehyde and lactate dehydrogenase enzyme was immobilized on the alde

104 jump results yields an unprecedented view of lactate dehydrogenase enzymology, confirming the timesca

105 With syngas, the upregulated (R)-lactate dehydrogenase gene represents a route of electro

106 regular need for pain medication, and higher lactate dehydrogenase had a negative impact on the thera

107 Therefore, interpreting T-jump results of lactate dehydrogenase kinetics has required extensive co

108 LLH was defined by a discharge lactate dehydrogenase level of 400 to 700 U/L.

109 hypoalbuminemia, thrombocytopenia, and high lactate dehydrogenase level, yielded a better C statisti

110 d brain metastases (20% v 14%) and increased lactate dehydrogenase levels (52% v 38%) at baseline; 41

111 interleukin-1beta [IL-1beta] secretion, and lactate dehydrogenase release) compared to that with the

112 tate dehydrogenase (5 years, 45%) and normal lactate dehydrogenase with fewer than three organ sites

113 ating levels of alanine aminotransferase and lactate dehydrogenase, and inflammatory mediators such a

114 e pathways, such as glycolysis, flux through lactate dehydrogenase, and the citric acid cycle (as inf

115 evidenced by increased creatinine kinase and lactate dehydrogenase, as well as expression of monocyte

116 ed International Prognostic Index, including lactate dehydrogenase, Eastern Cooperative Oncology Grou

117 teristic radiographic findings with elevated lactate dehydrogenase, or hospitalization for pneumonia

118 bstrates for yeast alcohol dehydrogenase and lactate dehydrogenase, respectively, with reaction rates

119 ed the contributions of macrophage-expressed lactate dehydrogenase-A (LDH-A) to tumor formation in a

120 aphic analysis of allosterically inhibited L-lactate dehydrogenase.

121 zyme for the study of reaction landscapes is lactate dehydrogenase.

122 sporter-1 (MCT1) from tumor cells eliminated lactate-dependent metabolite labeling, confirming tumor-

123 Impedimetric sensor allows lactate detection in the range from 3 mM to 100 mM with

124 ide-arms were examined as shift reagents for lactate detection.

125 17 and Tc1) cells, likely via suppression of lactate-driven PD-L1 expression.

126 ay be important, since the administration of lactate during hypoglycemia suppresses symptoms and coun

127 Evoked lactate dynamics, imaged in Colo357 spheroids using cyto

128 ypoxia-inducible factor (HIF) that increases lactate efflux as a result of enhanced glycolysis, but i

129 do this at an adequate rate is H(+)-coupled lactate efflux on monocarboxylate transporters (MCTs).

130 produced via biostimulation with an acetate/lactate electron donor mix in the sediments tested.

131 Furthermore, lactate entry into the better-perfused recipient cells h

132 In both fed and fasted mice, (13)C-lactate extensively labels TCA cycle intermediates in al

133 triphosphate but the relative importance of lactate fermentation and Oxidative Phosphorylation (OxPh

134 h in host cells from oxidative metabolism to lactate fermentation, increasing both lactate levels and

135 tridia, reprogram host metabolism to perform lactate fermentation, thus supporting Salmonella infecti

136 , the dynamic (13)C-labeling of pyruvate and lactate formed from (13)C-glucose was observed in real t

137 olic traits, including aerobic production of lactate from glucose (Warburg effect), extensive glutami

138 ucose was decreased, while the production of lactate from glutamine was enhanced.

139 ions as an alternative route for discharging lactate from pancreatic ductal adenocarcinoma (PDAC) cel

140 cancer cell survival, may explain the excess lactate generation under aerobic conditions characterist

141 In vitro evaluation of dual lactate-glucose microbiosensor revealed an extended line

142 These findings uncover the lactate-Gpr132 axis as a driver of breast cancer metasta

143 ut no difference between treatment groups in lactate greater than 2 mmol/L.

144 sion, received vasopressors, and exhibited a lactate greater than 2 mmol/L.

145 Patients had higher plasma cytokines in lactate greater than 2 versus less than or equal to 2 mm

146 re-extracorporeal membrane oxygenation blood lactate greater than 4 mmol/L (2.6 [1.03-6.4]) as indepe

147 lls, whereas RTG3 is upregulated in stressed lactate-grown cells.

148 f patients with Septic Shock 3.0 definition (lactate > 2 mmol/L) differ from vasopressin versus norep

149 tial normal lactate (< 2.2 mmol/L), elevated lactate (>/= 2.2 to < 4 mmol/L), or severe hyperlactatem

150 ) order in milk was calcium chloride>calcium lactate>calcium gluconate>calcium lactobionate.

151 Since altered brain lactate handling has been implicated in the development

152 on of the proposed biosensor for analysis of lactate in artificial serum samples was evaluated with g

153 Successful detection of lactate in human sweat by means of the poly(3-APBA) base

154 The role of exercise-induced lactate in mediating these effects, potentially serving

155 g coupled enzyme reactions for quantifying L-lactate in oral fluid, which is considered a biomarker o

156 tor delay, refractory epilepsy, and elevated lactate in the blood and cerebrospinal fluid.

157 h is actively accumulated and metabolized to lactate in the brain.

158 uestions regarding the controversial role of lactate in the brain.

159 s, but it also enhances gluconeogenesis from lactate in the liver that contributes to reducing circul

160 s, most displayed fermentation of glucose to lactate in the presence of oxygen.

161 olism is primarily indirect (via circulating lactate) in all tissues except the brain.

162 n type 1 diabetes, the capacity to transport lactate into the brain during hypoglycemia may be releva

163 Here, we show that lactate is also a TCA cycle carbon source for NSCLC.

164 We determined that lactate is an H. pylori chemoattractant that is sensed v

165 ld in fed mice and 2.5-fold in fasting mice; lactate is made primarily from glucose but also from oth

166 olar basis, the circulatory turnover flux of lactate is the highest of all metabolites and exceeds th

167 Lactate is utilised by H. pylori, and our work suggests

168 accumulation of higher organic acids (e.g., lactate, iso-butyrate, and propionate), which was accomp

169 The slope intercept of lactate kinetics over 48 hours was positive and signific

170 Lactate kinetics rather than initially elevated lactate

171 lation by initial lactate concentrations and lactate kinetics.

172 In this regard, l-lactate/lactic acid permeability has been shown for vari

173 ty with vasopressin versus norepinephrine in lactate less than or equal to 2 mmol/L but no difference

174 ls in Vasopressin and Septic Shock Trial for lactate less than or equal to 2 versus greater than 2 mm

175 asured 39 cytokines to compare patients with lactate less than or equal to 2 versus greater than 2 mm

176 ndividuals (88%) exhibited an elevated blood lactate level accompanied by generalized myopathy; only

177 56-69% of the response current at the same l-lactate level and minimized the relative bias error to -

178 To determine whether the initial serum lactate level is associated with 30-day mortality in chi

179 th increased mortality compared with a serum lactate level of 36 mg/dL or less.

180 31, 2015, tested the hypothesis that a serum lactate level of greater than 36 mg/dL is associated wit

181 for patients with worse shock (higher serum lactate level, combined hypotension and hyperlactatemia,

182 n part because the association between early lactate levels and mortality is unknown in pediatric sep

183 ism to lactate fermentation, increasing both lactate levels and Salmonella lactate utilization.

184 All had elevated lactate levels at admission without evidence of hypovole

185 ty occurred in 5 of 103 patients (4.8%) with lactate levels greater than 36 mg/dL and 20 of 1196 pati

186 The sensitivity of lactate levels greater than 36 mg/dL for 30-day mortalit

187 e observed significantly lower pH and higher lactate levels in the brains of model mice relative to c

188 Lactate levels in the culture medium starting from 50mic

189 butyrate levels, and substantially elevated lactate levels in the gut lumen.

190 Measurement of lactate levels is associated with improved outcomes in a

191 gest that lower pH associated with increased lactate levels is not a mere artifact, but rather implic

192 Measurement of lactate levels may have utility in early risk stratifica

193 36 mg/dL and 20 of 1196 patients (1.7%) with lactate levels of 36 mg/dL or less.

194 Initial lactate levels of greater than 36 mg/dL were significant

195 Extracellular lactate levels strongly correlated with T cell prolifera

196 IT (baseline) and during hypoglycemia, brain lactate levels were determined continuously with J-diffe

197 eginning of hypoglycemia (after HIIT), brain lactate levels were elevated in all groups but most pron

198 ted metabolomics revealed decreased cellular lactate levels, and altered levels of TCA cycle intermed

199 om another medical center, no measurement of lactate levels, and patients younger than 61 days or 18

200 We then measured pH, lactate levels, and related metabolite levels in brain h

201 ver that contributes to reducing circulating lactate levels.

202 , GLD4 affects glucose uptake into cells and lactate levels.

203 HIIT acutely increases plasma lactate levels.

204 nificant negative correlation between pH and lactate levels.

205 ty interval training (HIIT) increases plasma lactate levels.

206 Adipose-derived lactate likely contributes to high endogenous glucose pr

207 In patients with initial normal lactate (< 2.2 mmol/L), elevated lactate (>/= 2.2 to < 4

208 r development, and secretory function in the lactating mammary gland.

209 highest case volume were more likely to have lactate measured (adjusted odds ratio quartile 4 vs quar

210 among patients with septic shock, 68.3% had lactate measured and 64% received norepinephrine as init

211 with three evidence-based processes of care (lactate measurement during first hospital day, norepinep

212 tures, broad-spectrum antibiotic agents, and lactate measurement) completed within 12 hours.

213 We conclude that the use of extracellular lactate measurements can be a sensitive, safe, stable, a

214 itrosative stress, anaerobic respiration and lactate metabolism.

215 Here we found that ZnT2 deletion in lactating mice and cultured MECs resulted in Zn(2+)-medi

216 Lactating mothers drank vegetable, beet, celery, and car

217 What lactating mothers eat flavors breast milk and, in turn,

218 cells, to the potential beneficiary from the lactate, neurons-prompts new questions regarding the con

219 f the current oxygen sensing hypotheses: the lactate-Olfr 78 hypothesis of oxygen chemotransduction;

220 such phenotypes were reversed by its product lactate or antioxidant N-acetylcysteine, suggesting that

221 The quantitative relevance of circulating lactate or other metabolic intermediates as fuels remain

222 ystemic inflammatory response syndrome "and" lactate ordered, or less than or equal to 60 minutes fro

223 bolic products, [(13)C]-labeled pyruvate and lactate, originating from glycolysis.

224 Hindlimb glucose uptake and lactate output rates were similar between groups, wherea

225 l-lactate biosensors employing l-lactate oxidase (LOx) have been developed mainly to meas

226 he highly specific reference method based on lactate oxidase enzyme (correlation coefficient r > 0.9)

227 abundance of taurine, isoglutamine, choline, lactate, phenylalanine and tyrosine and decreased levels

228 NMR shift reagent for imaging extracellular lactate produced by cancer cells using CEST imaging.

229 amino acid substitutions into the E. coli D-lactate producer TG114, 94% of a glucose-xylose mixture

230 A greater proportion of lactate-producing bacteria (such as Lactobacillus, Turic

231 tyrin or a PPARgamma agonist diminished host lactate production and abrogated the fitness advantage c

232 feration and increasing glucose consumption, lactate production and ATP generation.

233 hemoAML) had higher lipid content, increased lactate production and ATP levels, reduced expression of

234 coupled to a metabolic shift with increased lactate production and elevated expression of glycolytic

235 tion of IL-1beta into the airways stimulated lactate production and expression of glycolytic enzymes,

236 Pkm2-deleted CGNPs showed reduced lactate production and increased SHH-driven proliferatio

237 hloro-dl-tryptophan prevented both increased lactate production and reduced migration toward chemokin

238 Increased lactate production by spheroids upon suppression of the

239 The dose-dependent decrease in lactate production caused by the addition of the hepatot

240 lomic profiling revealed that MCAM modulated lactate production in chemoresistant cells that exhibit

241 ed reactive oxygen species (ROS), leading to lactate production through hypoxia-inducible factor-1alp

242 iciency leads to enhanced glucose uptake and lactate production through upregulation of c-Myc.

243 ally oxygen uptake, glucose consumption, and lactate production) and the cellularity of tissue-engine

244 h LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaP

245 ed the dysregulation of glycolytic genes and lactate production, and partially restored mitochondrial

246 itro increases oxygen consumption, decreases lactate production, inhibits clonal growth, migration an

247 rs and elucidate the mechanisms of excessive lactate production.

248 ose use, expression of glycolysis genes, and lactate production.

249 atalyses the interconversion of pyruvate and lactate, promotes cancer cell invasion, anoikis resistan

250 nal activity is fueled (at least in part) by lactate provided by neighboring astrocytes.

251 lar ATP, extracellular metabolites (glucose, lactate, pyruvate), and oxygen consumption rate (OCR).

252 antly higher pyruvate-to-lactate conversion (lactate/pyruvate + lactate ratio) was found 2 days after

253 t induced metabolic deficits as evidenced by lactate/pyruvate ratio (LPR) elevation (a clinically-est

254 Lactate racemase is the first enzyme known to possess a

255 port a synthetic model of the active site of lactate racemase, which features a pyridinium-based SCS

256 ntaining cofactor into LarA, an Ni-dependent lactate racemase.

257 genation of alcohols, a reaction relevant to lactate racemization.

258 te-to-lactate conversion (lactate/pyruvate + lactate ratio) was found 2 days after treatment with paz

259 reduction in both tonic and hypoxia-induced lactate release in the cerebral cortex, which was normal

260 that NO modulates the size of the astrocytic lactate reservoir involved in neuronal fueling and signa

261 om "time-zero," whichever occurs earlier; 3) lactate result available less than or equal to 90 minute

262 Infusing human NSCLC patients with (13)C-lactate revealed extensive labeling of TCA cycle metabol

263 ; increased temperature gave increased blood lactate, rigor index (Ir), drip loss (DL), content of as

264 whole blood (FWB), (2) SAAP with oxygenated lactated Ringer's (LR), 1,600 mL/2 min, or (3) SAAP with

265 sodium chloride) and balanced crystalloids (lactated Ringer's solution or Plasma-Lyte A).

266 nd glucose metabolism in vivo indicated that lactate's contribution to the TCA cycle predominates.

267 regulation of glucose transporter-1 (Glut1), lactate secretion and induced cellular invasion by upreg

268 sion of FBP1 decreased glucose reduction and lactate secretion and inhibited HCC cell growth in vitro

269 The amperometric-based lactate sensor consists of doped enzymes deposited on to

270 The astrocyte-neuron lactate shuttle hypothesis suggests that neuronal activi

271 Local astrocytic lactate shuttling was not required.

272 ity in Vasopressin and Septic Shock Trial in lactate subgroups.

273 g of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between differen

274 Lactate testing is prepopulated in the institutional sep

275 tic cancer cells produce large quantities of lactate that must be removed to sustain metabolism in th

276 y SOD1(G93A) neurons had lower extracellular lactate, those with only SOD1(G93A) astrocytes exhibited

277 ficant increase of the conversion of MG to D-lactate through the glyoxalase system.

278 n-chain energy metabolites like pyruvate and lactate to neurons.

279 Despite CCI, the HP [1-(13)C] lactate-to-pyruvate ratio at the injury cortex of microg

280 Our results show that HP [1-(13)C] lactate-to-pyruvate ratios were increased in the injured

281 thalamic area (LHA) by impairing glucose and lactate trafficking through astrocytic networks.

282 deficit due to impaired hemichannel-mediated lactate transport between astrocytes and neurons as a po

283 leads to hemichannel dysfunction and impairs lactate transport in the cerebral cortex using rat model

284 The association between at admission lactate, unmeasured anions, and chloride concentration w

285 e labeling, confirming tumor-cell-autonomous lactate uptake.

286 r work suggests that this pathogen seeks out lactate using chemotaxis.

287 In human NSCLC, evidence of lactate utilization was most apparent in tumors with hig

288 fitness advantage conferred on Salmonella by lactate utilization.

289 ncreasing both lactate levels and Salmonella lactate utilization.

290 6 weeks, as well as decreased acquisition of lactate-utilizing bacteria producing butyrate, namely Eu

291 n lowered mortality versus norepinephrine if lactate was less than or equal to 2 mmol/L.

292 O2 concentration (>30 min) to almost zero as lactate was produced, and a subsequent decrease in pH wi

293 pathway measured by conversion of glucose to lactate was significantly higher when tethered.

294 Extracellular lactate was stably produced over 7 d, and results were r

295 promotes L-2HG accumulation via synthesis of lactate, which activates a metabolic feed-forward mechan

296 catabolized anaerobically via glycolysis to lactate, which is itself also a potential nutrient for t

297 s underlie the protective phenotype found in lactating women.

298 alf of the RDA of vitamin A for pregnant and lactating women.

299 ptimal iodine status especially for pregnant/lactating women.

300 vidence for the formation of stereoselective lactate.YbDO3A-trisamide complexes each with a different