ライフサイエンスコーパス: lactic acidosis

1 aprevir-ritonavir-dasabuvir may cause type B lactic acidosis.

2 t rate and systemic vascular resistance, and lactic acidosis.

3 elay, lethargy, severe hypotonia, and modest lactic acidosis.

4 ctate, making them specialized for detecting lactic acidosis.

5 in body fat distribution, dyslipidemia, and lactic acidosis.

6 es, branched-chain ketoaciduria, and primary lactic acidosis.

7 e, global neurodevelopmental regression, and lactic acidosis.

8 rdynamic, tachycardic state with progressive lactic acidosis.

9 dead space ventilation and exercise-induced lactic acidosis.

10 ed to hypovolemia, tissue hypoperfusion, and lactic acidosis.

11 erature, heart rate, oxygen consumption, and lactic acidosis.

12 epatic metabolism, intestinal infarction and lactic acidosis.

13 ive to treatment and causing oxygen debt and lactic acidosis.

14 and CotH expression, an effect not seen with lactic acidosis.

15 gram, marked elevation of serum enzymes, and lactic acidosis.

16 year-old man who died with linezolid-induced lactic acidosis.

17 mplex II deficiency, were found to have mild lactic acidosis.

18 and serologic evidence of liver failure and lactic acidosis.

19 not been associated with increased rates of lactic acidosis.

20 genase enzyme activity but most did not have lactic acidosis.

21 aired kidney function because of concerns of lactic acidosis.

22 ab work was significant for leukocytosis and lactic acidosis.

23 in was not associated with increased risk of lactic acidosis.

24 vival of cells after exposure to hypoxia and lactic acidosis.

25 lls is abolished by simultaneous exposure to lactic acidosis.

26 ng the origins and treatment of pathological lactic acidosis.

27 nd hyperglycemia, possibly mediated by brain lactic acidosis.

28 e molecule used by sensory neurons to detect lactic acidosis.

29 brain damage during ischemia due to enhanced lactic acidosis.

30 and catecholamines were responsible for the lactic acidosis.

31 35%), mixed venous saturation (by 65%), and lactic acidosis (5.5-6.0 mM).

32 In particular, lactic acidosis abolished stabilization of HIF-1alpha pr

33 ondrial inner membrane to undergo fusion and lactic acidosis after the loss of outer membrane fusion.

34 rine metabolite studies showed hypoglycemia, lactic acidosis, altered Krebs cycle function and dysreg

35 e characterized by fetal growth retardation, lactic acidosis, aminoaciduria, cholestasis, and abnorma

36 An infant presented with fatal infantile lactic acidosis and cardiomyopathy, and was found to hav

37 drome patients in having intermittent severe lactic acidosis and early-onset neurodevelopmental probl

38 ion who were taking stavudine presented with lactic acidosis and elevated levels of aminotransferases

39 Both affected individuals presented with lactic acidosis and evidence of multiple mitochondrial r

40 three families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal l

41 In patients with acute lactic acidosis and ketoacidosis, lactate and ketone bod

42 Q(10) deficiency who presented with neonatal lactic acidosis and later developed multisytem disease i

43 Routine blood tests showed lactic acidosis and mild elevation of the creatine kinas

44 All case subjects presented with lactic acidosis and nine developed hypertrophic cardiomy

45 with failure to thrive, developmental delay, lactic acidosis and severe encephalopathy suggestive of

46 Mitochondrial myopathy with lactic acidosis and sideroblastic anemia (MLASA) is an o

47 en use in five severely septic patients with lactic acidosis and six healthy volunteers before and af

48 ds harboring mitochondrial encephalomyopathy lactic acidosis and stroke A3243G tRNA((Leu)UUR) gene mu

49 her the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (A3243G MELAS)

50 such as mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) and myo

51 of the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) phenoty

52 suggestive of mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrom

53 osis (ALS), mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), dermat

54 romes including mitochondrial encephalopathy lactic acidosis and stroke-like episodes (MELAS), matern

55 tation causing mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS); the tR

56 are part of the mitochondrial encephalopathy lactic acidosis and stroke-like episodes syndrome.

57 MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) and MIDD syndr

58 Melas (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) is one of a gr

59 (Mitochondrial Myopathy, Encephalopathy with Lactic Acidosis and Stroke-like episodes) syndrome, the

60 ssociated with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes, but were docum

61 me, and mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.

62 muscle and, therefore, is proposed to detect lactic acidosis and to transduce angina and muscle ische

63 erum fibrinogen, elevated prothrombin time), lactic acidosis, and hepatic steatosis were characterist

64 Within solid tumor microenvironments, lactic acidosis, and hypoxia each have powerful effects

65 d Ca accumulation, attenuated sepsis-related lactic acidosis, and improved left ventricular function.

66 d vision, promoted feeding behavior, reduced lactic acidosis, and increased survival.

67 e-threatening syndrome of hepatic steatosis, lactic acidosis, and myopathy has been reported.

68 cs, increased glycolysis, glutaminolysis and lactic acidosis, and neurotransmitter imbalances.

69 , an increase in pulse and respiratory rate, lactic acidosis, and renal failure.

70 hildren present with a fatal encephalopathy, lactic acidosis, and severe mtDNA depletion in muscle.

71 ssociated with a clinical triad of myopathy, lactic acidosis, and sideroblastic anemia in predominant

72 h as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke (MELAS), neuropathy, ataxia,

73 tient carrying the myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) A3243G

74 the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndro

75 underlying mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndro

76 Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), a mat

77 tients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes.

78 tion causes mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms (MELAS) and 2%

79 n in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS).

80 , including mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS).

81 Metformin poisoning with lactic acidosis appears to be amenable to extracorporeal

82 Since Coffin-Lowry syndrome and neonatal lactic acidosis are associated with mutations in the hum

83 ver toxicity, hypersensitivity reactions and lactic acidosis are recognized as acute events with pote

84 a has many manifestations, of which coma and lactic acidosis are the best independent predictors of a

85 opathy, peripheral neuropathy, myopathy, and lactic acidosis associated with deficiencies of multiple

86 who presented with exercise intolerance and lactic acidosis associated with severe deficiency of com

87 The first presented with acute lactic acidosis at 3 weeks of age and developed severe d

88 at 32 degrees C attenuated the shock-related lactic acidosis but caused metabolic acidosis, most like

89 ndrial toxicity (i.e., neuropathy, myopathy, lactic acidosis), but these side effects are rarely repo

90 fever, tachycardia, oxygen consumption, and lactic acidosis, but it does not prevent the development

91 Severe symptoms include seizures, lactic acidosis, cardiac arrhythmia, and death within da

92 ever, the dominant theory in the field, that lactic acidosis causes muscle fatigue, is unlikely to te

93 to occur in a variety of diseases including lactic acidosis, Cowden Syndrome, and several cancers.

94 Lactic acidosis developed during continuous infusion of

95 In both groups, a significant lactic acidosis developed during exercise and the magnit

96 or patients with critical tissue hypoxia and lactic acidosis due to anemia.

97 I suggest that lactic acidosis due to malaria can be explained primaril

98 Among children with lactic acidosis due to severe anemia, transfusion of lon

99 No patients developed metformin-associated lactic acidosis during follow-up.

100 nly has been assumed that the development of lactic acidosis during sepsis results from a deficit in

101 sive myocardial thickening, hyperalaninemia, lactic acidosis, exercise intolerance, and persistent ad

102 were significantly (P < 0.05) protected from lactic acidosis, glutamate buildup, and diminished HCO(3

103 severe neurological dysfunction, congenital lactic acidosis, growth retardation, and early death.

104 ated individuals who presented at birth with lactic acidosis, hypotonia, feeding difficulties, and de

105 al MCT1 may contribute to the development of lactic acidosis in brain pathologies, and suggest target

106 pertaining to metformin, kidney disease, and lactic acidosis in humans between 1950 and June 2014.

107 Lactic acidosis in malaria can be treated safely with di

108 The overall incidence of lactic acidosis in metformin users varies across studies

109 Data suggesting an increased risk of lactic acidosis in metformin-treated patients with chron

110 Interstitial lactic acidosis in the donor allograft is associated wit

111 e patients with severe exercise intolerance, lactic acidosis in the resting state (in four patients),

112 cultures with concurrent vasopressors and/or lactic acidosis increased (P < .001 for all methods), wh

113 Lactic acidosis, induced by the addition of 25 mm lactic

114 ing brain diseases, such as stroke, in which lactic acidosis is a key component.

115 Linezolid-induced lactic acidosis is associated with diminished global oxy

116 Lactic acidosis is being re-evaluated as a factor in mus

117 The widely prevalent idea that lactic acidosis is responsible for hyperglycemia-enhance

118 Lactic acidosis (LA) frequently occurs after heart trans

119 , it is known to induce metformin-associated lactic acidosis (MALA), a severe medical condition with

120 <1%) patient in the doxorubicin alone group (lactic acidosis [n=1]).

121 ghei malaria, (ii) respiratory distress with lactic acidosis occurs during P. berghei malaria, and (i

122 logies, anaerobic glycolysis produces severe lactic acidosis of brain tissue leading to brain cell da

123 at express ASICs an extra sensitivity to the lactic acidosis of local ischemia compared to acidity ca

124 ith serious metabolic complications, such as lactic acidosis, pancreatitis, and peripheral neuropathy

125 Our findings reveal that the condition of lactic acidosis present in solid tumors inhibits canonic

126 trovirals are well characterized and include lactic acidosis related to nucleoside reverse transcript

127 cultures with concurrent vasopressors and/or lactic acidosis remained stable (P = .098).

128 fection who all presented with severe type B lactic acidosis shortly after starting treatment with om

129 ome (mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes) is a rare, multis

130 In contrast, lactic acidosis strongly synergized with hypoxia to acti

131 cytochrome c oxidase deficiency and hepatic lactic acidosis that accompanies this disorder is unknow

132 Lactic acidosis--the strongest prognostic indicator in a

133 desaturation when performing work above the lactic acidosis threshold (LAT), but not below it.

134 h a clinical spectrum ranging from infantile lactic acidosis to childhood (cardio)myopathy and late-o

135 alpha alpha Hb (n = 6) resulted in hypoxia, lactic acidosis, ventricular arrhythmias, and decreased

136 Lactic acidosis was no more common in metformin recipien

137 No cases of lactic acidosis were observed.

138 s associated with hemodynamic depression and lactic acidosis, which appeared (illustrative echocardio

139 mitochondrial myopathy, encephalopathy, and lactic acidosis with stroke-like episodes (MELAS) and Pa