ライフサイエンスコーパス: lactide

1 triblock polymers, where PLA stands for poly(lactide).

2 a change in the rate of polymerization of L-lactide.

3 during the ring-opening polymerization of L-lactide.

4 enyl isocyanate and the polymerization of DL-lactide.

5 as initiators for the polymerization of rac-lactide.

6 the catalyzed ring opening polymerization of lactide.

7 tal-catalyzed ring-opening polymerization of lactide.

8 and utilized in the polymerization of (rac)-lactide.

9 nthrax infection, was encapsulated in poly-L-lactide 100-kDa microspheres.

10 ted with a 10% copolymer solution of 50:50 L-lactide and epsilon-caprolactone were statically seeded

11 during the ring-opening polymerization of l-lactide and epsilon-caprolactone.

12 he controlled ring-opening polymerization of lactide and epsilon-caprolactone.

13 ymer scaffolds fabricated from copolymers of lactide and glycolide were adsorbed with collagen IV, fi

14 nd biodegradable PLGA (a random copolymer of lactide and glycolide) to form a nanofibrous non-woven s

15 t tissues were fabricated from copolymers of lactide and glycolide.

16 ormation pertaining to the polymerization of lactide and other cyclic esters by discrete metal alkoxi

17 omonomers including commercially available l-lactide and trimethylene carbonate produced novel copoly

18 1,4-dioxane-2,5-dione was synthesized from L-lactide and used as the dienophile to prepare spiro[6-me

19 are first order with respect to monomer (rac-lactide) and 1.56 order in catalyst.

20 or transforming meso-LA directly into poly(L-lactide) and D-LA.

21 ac-LA is kinetically polymerized into poly(L-lactide) and optically resolved D-LA, with a high stereo

22 ic multi-block copolymers composed of poly(l-lactide) and poly ethylene glycol/poly(-caprolactone), a

23 The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved propert

24 copolymers of clinically validated poly(D,L-lactide) and poly(ethylene glycol) (PEG-Dlink(m)-PDLLA)

25 ing around Ti-6Al-4V, poly(L-lactide-co-D,L,-lactide), and 303 stainless steel implants with surface

26 -opening of the cyclic esters L-lactide, rac-lactide, and 2,5-morpholinediones.

27 ion in the stereoselective polymerization of lactide are described.

28 the ring-opening polymerization (ROP) of rac-lactide are rare outside of Group 13.

29 ontrolled ring-opening polymerization of rac-lactide are reported.

30 erized l-lactide, whereas endo-6 preferred d-lactide as the substrate.

31 udies also showed that L(1)ZnOEt polymerizes lactide at a rate faster than any other Zn-containing sy

32 catalyze the ring-opening polymerization of lactide at elevated temperatures to give narrowly disper

33 rto unknown high activity for the ROP of rac-lactide at room temperature.

34 reocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly

35 y(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in wate

36 trated by their use in the synthesis of poly(lactide)-b-poly(butenediol)-b-poly(lactide) triblock cop

37 FA coupled poly(l-lactide)-b-poly(ethylene glycol) (FA-PEG-PLLA) was synth

38 llable lengths of both styrene carbonate and lactide blocks.

39 studies reveal a first-order dependence on [lactide], but with a significant induction period.

40 ion from a dynamic combinatorial library and lactide can be converted to (MeCHC(O)O)6 in >80% yield.

41 rned matrix based on acrylate-functionalized lactide-chain-extended star polyethylene glycol (SPELA)

42 e encapsulated SOD in biodegradable poly(D,L-lactide co-glycolide) nanoparticles (SOD-NPs) and tested

43 ne serum albumin (BSA) in injectable poly(DL-lactide- co-glycolide) (PLGA) 50/50 cylindrical implants

44 We assessed healing around Ti-6Al-4V, poly(L-lactide-co-D,L,-lactide), and 303 stainless steel implan

45 days of culture in the presence of poly(D,L-lactide-co-epsilon-caprolactone) (PDLLCL), poly(ethylene

46 monstrate that the prevascularized poly (D,L-lactide-co-epsilon-caprolactone) scaffold maintains viab

47 cutaneously implanted, retrievable poly (D,L-lactide-co-epsilon-caprolactone) scaffold.

48 The coating consisted of absorbable poly-lactide-co-glycolic acid (PLGA) and crystalline sirolimu

49 tion of a US contrast agent composed of poly-lactide-co-glycolic acid polymeric (PLGA) microspheres (

50 Biocompatible poly lactide-co-glycolide (PLGA) nanoparticles containing enc

51 ctone (PCL), poly-D,L-lactide (PLA), or poly-lactide-co-glycolide (PLGA), and hydrophilic blocks of p

52 matory mediators, encapsulated into poly(d,l-lactide-co-glycolide acid) (PLGA), and coated with a fin

53 eded onto tubularised polyglycolic acid:poly(lactide-co-glycolide acid) scaffolds.

54 deslorelin or transferrin-conjugated poly-l-lactide-co-glycolide nanoparticles (PLGA-NPs) encapsulat

55 Using poly-lactide-co-glycolide scaffolds as cell carriers, we tran

56 en-conjugated NPs made of biodegradable poly(lactide-co-glycolide) (Ag-PLG) are similarly effective p

57 this approach was evaluated by using 3D poly(lactide-co-glycolide) (PLAGA) sintered microsphere scaff

58 otein bovine serum albumin (BSA)-loaded poly(lactide-co-glycolide) (PLG) core and drug-free poly(d,l-

59 on was achieved via hydrolysis of 85:15 poly(lactide-co-glycolide) (PLG) films.

60 virus RNA replicons (pSINCP), cationic poly(lactide-co-glycolide) (PLG) microparticles for DNA deliv

61 Os required a bioartificial microporous poly(lactide-co-glycolide) (PLG) scaffold niche for successfu

62 nvestigated the surface modification of poly(lactide-co-glycolide) (PLG) scaffolds with polysaccharid

63 Matrices of poly(lactide-co-glycolide) (PLG) were loaded with plasmid, wh

64 ition 50:50 poly (DL-lactide) (PLA)/poly (DL-lactide-co-glycolide) (PLG) with an inherent viscosity o

65 Here, we produce poly(lactide-co-glycolide) (PLGA) based microparticles with v

66 Poly(lactide-co-glycolide) (PLGA) has most often been employe

67 The NS made using GA conjugated poly(lactide-co-glycolide) (PLGA) have shown non-competitive

68 In this study we prepared large porous poly(lactide-co-glycolide) (PLGA) microparticles of celecoxib

69 Poly (dl-lactide-co-glycolide) (PLGA) nanoparticles of acerola, g

70 We show that VP5k-coated poly(lactide-co-glycolide) (PLGA) nanoparticles rapidly penet

71 to 50% in the group using biodegradable poly(lactide-co-glycolide) (PLGA) nonwoven nanofibrous membra

72 Nanoparticles composed of poly(lactide-co-glycolide) (PLGA) or diblock copolymers of PE

73 used to encapsulate the MRI agent in a poly(lactide-co-glycolide) (PLGA) or polylactide-poly(ethylen

74 series of bioresorbable polymers, i.e., poly(lactide-co-glycolide) (PLGA), poly(lactic acid) (PLLA),

75 s) formulated from the copolymers of poly(DL-lactide-co-glycolide) (PLGA).

76 In this study, we used cationic lipid-poly(lactide-co-glycolide) acid (PLGA) hybrid nanoparticles a

77 We use poly(lactide-co-glycolide) copolymer (PLGA) fiber microfilame

78 s elicited by a vaccine system based on poly(lactide-co-glycolide) micro- or nano-particles enveloped

79 tidylic acid) (polyIC) in biodegradable poly(lactide-co-glycolide) microparticles (MPs) designed to r

80 th either H7 or H7 incorporated into poly(DL-lactide-co-glycolide) microparticles (PLG:H7).

81 ovine serum albumin was encapsulated in poly(lactide-co-glycolide) microparticles and was administere

82 Poly(lactide-co-glycolide) microparticles approximately 1 mum

83 of either polystyrene or biodegradable poly(lactide-co-glycolide) microparticles bearing encephalito

84 Heparin-loaded biodegradable poly (D,L-lactide-co-glycolide) microparticles were prepared by sp

85 ated MAP in PBS and encapsulation in poly(DL-lactide-co-glycolide) microparticles.

86 0 to 500 microns ganciclovir-loaded poly(D,L-lactide-co-glycolide) microspheres control the progressi

87 h a collagen matrix, was added to a poly (DL-lactide-co-glycolide) polymer (PLG) and placed at orthot

88 y to nanoparticles formulated using poly(D,L lactide-co-glycolide) polymer.

89 , PTX was covalently conjugated to poly (D,L-lactide-co-glycolide) polymeric core by redox-sensitive

90 bioabsorbable nanofibrous membranes of poly(lactide-co-glycolide) were effective to reduce adhesions

91 oparticles were prepared with PLGA [poly(d,l-lactide-co-glycolide), 50:50, MW.

92 -printed patches composed of a blend of poly(lactide-co-glycolide), polycaprolactone, and 5-fluoroura

93 gradable and biocompatible polymer, poly(d,l-lactide-co-glycolide), was used to fabricate curcumin mi

94 orous scaffolds of biomineralized 85:15 poly(lactide-co-glycolide), which locally release vascular en

95 n of a cationic amphiphilic copolymer, poly (lactide-co-glycolide)-graft-polyethylenimine (PgP) and i

96 (density, >1g/ml) microspheres of 85:15 poly(lactide-co-glycolide).

97 Poly(L-lactide-co-glycolide)based devices loaded with VEGF were

98 thetic controlled-release biomaterials, poly(lactide-co-glycolide; PLGA) microparticles (MPs) encapsu

99 uncoated or coated with a thin layer of poly(lactide-co-sigma-caprolactone) copolymer alone or contai

100 Poly(lactide-co-sigma-caprolactone) copolymer-coated stents p

101 v adsorbed onto the surface of cationic poly(lactide-coglycolide) (PLG) microparticles were shown to

102 tavirus VP6 DNA vaccine encapsulated in poly(lactide-coglycolide) (PLG) microparticles.

103 poration of peptides in bioadhesive poly(D,L-lactide-coglycolide) (PLGA) microparticles, the use of m

104 ound I nanoparticle (compound I-NP)] in poly(lactide-coglycolide) (PLGA) was developed that shows sus

105 Poly (D,L-lactide-coglycolide) nanocapsules (NC) were used to enca

106 ogenic inhibitor, was encapsulated with poly(lactide-coglycolide) to form K5 nanoparticles (K5-NP).

107 hrough self-assembly of a biodegradable poly(lactide-coglycolide)-b-poly(ethylene glycol) diblock cop

108 A bioabsorbable membrane of glycolide and lactide copolymer was sutured over the defect to maximiz

109 he synthesis of poly(styrene carbonate-block-lactide) copolymers.

110 ive and controlled polymerization of racemic lactide (D,L-LA) using an initiator prepared in situ fro

111 zation of several common monomers, including lactide, delta-valerolactone, epsilon-caprolactone, a cy

112 Polymerizations of this bifunctional lactide derivative were successfully carried out under r

113 periments reported here on a poly(isoprene-b-lactide) diblock copolymer melt.

114 mmetric low molar mass poly(isoprene)-b-poly(lactide) diblock copolymers reveal an extraordinary ther

115 ld enable a sequential polymerization of the lactide enantiomers to afford stereoblock copolymers wit

116 bles controlled copolymerization of OCAs and lactide, facilitating the synthesis of block copolymers

117 mately 10 to approximately 110 mug/min), and lactide from polylactic acid (PLA) filaments (ranging fr

118 disc composed of biodegradable poly-(D),(L)-lactide/glycolide copolymer.

119 a-butyrolactone, and D, L, meso, and racemic lactides has been studied with the PHB-depolymerase (P.

120 tion of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with ea

121 in the polymerization of either meso- or rac-lactide, homochiral 4 was found to exhibit excellent ste

122 n a sphere (micelle) forming poly(isoprene-b-lactide) (IL) diblock copolymer melt, investigated as a

123 cticity to produce stereoblock PLA, from rac-lactide improves thermal properties but is an outstandin

124 zwitterionic ring-opening polymerization of lactide initiated by N-heterocyclic carbenes generates c

125 e copolymer poly(ethylene glycol)-b-poly(d,l-lactide) into well-defined nanotubes.

126 )Cl(-) (PPN(+)Cl(-)) selectively polymerizes lactide (L and rac) dissolved in neat propylene oxide (P

127 ol (PEG) macromers chain-extended with short lactide (L) and glycolide (G) segments were used for gra

128 CsA-initiated ring-opening polymerization of lactide (LA) followed by nanoprecipitation.

129 chemo- and regioselective polymerizations of lactide (LA) followed by nanoprecipitation.

130 ered to catalyze rapid epimerization of meso-lactide (LA) or LA diastereomers quantitatively into rac

131 for the ring-opening polymerization (ROP) of lactide (LA) to form poly(lactic acid) (PLA) at room tem

132 olymerizations of -caprolactone (CL) and D,L-lactide (LA) were performed.

133 t block copolymerization of betaMdeltaVL and lactide leads to a new class of high-performance polyest

134 on of styrene and divinylbenzene from a poly(lactide) macro-chain transfer agent in the presence of n

135 The ring-opening polymerization of L-lactide mediated by these alcohol-bonded thioimidates yi

136 In addition, celecoxib-poly(lactide) microparticles (750 microg drug/rat) were admin

137 With celecoxib-poly(lactide) microparticles, choroid-RPE, retina, and vitreo

138 e form or orally after encapsulation in poly(lactide) microspheres, induced significant protective im

139 study indicates that insertion of the first lactide monomer into the tin(II) alkoxide bond is facile

140 ed for up to fifteen sequential additions of lactide monomer to the polymerization reaction.

141 VEGF detection, and incorporated with poly-L-lactide nanoparticles (PLLA NPs) for signal amplificatio

142 yclooctadiene) and copolymerizing it with DL-lactide, novel polymeric alloys of PLA can be created th

143 Our previous study showed that poly(d,l-lactide) NPs conjugated with an antielastin antibody cou

144 Poly(d,l-lactide) NPs were loaded with BB-94 and conjugated with

145 ies on self-assembly of poly(butadiene)-poly(lactide) (PB-PLA) diblock copolymers followed by selecti

146 Poly(ethylene oxide)-co-poly(d,l-lactide) (PEG-PDLA) formed micelles with elastic amorpho

147 ning PLGA and poly(ethylene glycol)/poly(D,L-lactide) (PEG-PLA) blends (n = 9, P = 0.03).

148 into larger poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PLA) NPs (~70nm).

149 s cores while poly(ethylene oxide)-co-poly(l-lactide) (PEG-PLLA) formed micelles with solid crystalli

150 seed and skin were stabilized with poly-d,l-lactide (PLA) polymer by the emulsion-evaporation method

151 ), poly-epsilon-caprolactone (PCL), poly-D,L-lactide (PLA), or poly-lactide-co-glycolide (PLGA), and

152 ed bone allograft (DFDBA) (BG+PDox); poly(DL-lactide) PLA barrier without doxycycline + DFDBA (BG+P);

153 sembled from a block copolymer of poly (D, L-lactide) (PLA) and monomethoxy polyethylene glycol (mPEG

154 cells were cultured within either poly (D,L-lactide) (PLA) or a fused fiber ceramic and evaluated fo

155 ssfully applied to mixtures of cyclic poly(L-lactide) (PLA) with increasing amounts of its linear top

156 zations of selected diluents with a poly(d,l-lactide) (PLA), polydimethylsiloxane (PDMS), or polystyr

157 polymer film with composition 50:50 poly (DL-lactide) (PLA)/poly (DL-lactide-co-glycolide) (PLG) with

158 Poly(l-lactide) (PLLA) is the structural material of the first

159 Poly(l-lactide) (PLLA)-based nanoparticles have attracted much

160 ly to one of three treatment groups: poly(DL-lactide) polylactic acid (PLA) barrier containing 4% dox

161 These case reports suggest that a poly(DL-lactide) polymer can be used as a physical barrier with

162 yttrium alkoxides and their application for lactide polymerization are reported.

163 n, structural characterization, and detailed lactide polymerization behavior of a new Zn(II) alkoxide

164 PLA chain length in controlled solvent-free lactide polymerization combined with heavy-atom substitu

165 e oxidation state of the catalyst: selective lactide polymerization was observed in the iron(II) oxid

166 When redox reactions were carried out during lactide polymerization, catalysis could be switched off

167 thogonal to what was observed previously for lactide polymerization.

168 complex that was completely inactive toward lactide polymerization.

169 Although reactions such as oxirane and lactide polymerizations are fairly well-known now with f

170 xhibit excellent stereocontrol in a range of lactide polymerizations.

171 extremely fast for the polymerization of rac-lactide, polymerizing 500 equiv in 96% yield in less tha

172 oabsorbable membranes, made of glycolide and lactide polymers.

173 catalyst to these polyols in the presence of lactides produces well-defined triblock copolymers (PLA-

174 zed ring-opening polymerization (ROP) of rac-lactide (rac-LA).

175 e in the ring-opening of the cyclic esters L-lactide, rac-lactide, and 2,5-morpholinediones.

176 n and the ring-opening polymerization of d,l-lactide, respectively.

177 e less reactive but do show some ability for lactide ring-enlarging.

178 functional adducts were used to prepare poly(lactide)s of more complex architectures.

179 effect the stereoselective polymerization of lactides starting from a single achiral precursor and th

180 (0) = 0.84 M, [InX(3)](0)/[BnOH](0) = 1) and lactide stereoisomer (i.e., k(obs)(D,L-LA) approximately

181 cribe an approach to ordered nanoporous poly(lactide) that relies on self-assembly of poly(butadiene)

182 For lactide this is shown to form the basis for chemical amp

183 PLGA with different lactide to glycolide (50:50 and 65:35) ratios were used

184 (PLA), while rac-4 polymerizes meso- and rac-lactide to heterotactic and isotactic stereoblock PLA, r

185 LA without epimerization of the monomer, rac-lactide to heterotactic PLA (P(r) = 0.94 at 0 degrees C)

186 [(BDI-1)ZnO(i)()Pr](2) polymerized (S,S)-lactide to isotactic PLA without epimerization of the mo

187 died for the polymerization of rac- and meso-lactide to poly(lactic acid) (PLA).

188 c PLA (P(r) = 0.94 at 0 degrees C), and meso-lactide to syndiotactic PLA (P(r) = 0.76 at 0 degrees C)

189 Enantiomerically pure 4 polymerizes meso-lactide to syndiotactic poly(lactic acid) (PLA), while r

190 ntly initiate ring-opening polymerization of lactide to synthesize the diblock copolymers.

191 formed absorbable polymer barrier of poly(DL-lactide) to enhance graft containment.

192 s of poly(lactide)-b-poly(butenediol)-b-poly(lactide) triblock copolymers.

193 ators for the ring-opening polymerization of lactide under mild conditions, providing polymers with c

194 tion of an in situ formed barrier of poly(DL-lactide) used in combination with a composite graft of d

195 lute stereochemistry of ring-opening of meso-lactide using (R)-4, a polymer exchange mechanism is pro

196 sms for the ring-opening polymerization of l-lactide using a guanidine-based catalyst, the first invo

197 The polymerization of lactide using this complex proceeded with good molecular

198 the PHB-depolymerase toward propylation of L-lactide was studied.

199 A bioabsorbable polymer barrier of poly(DL-lactide) was used in conjunction with a composite graft

200 Thus, exo-6 preferentially polymerized l-lactide, whereas endo-6 preferred d-lactide as the subst

201 tyrene) and poly(trimethylsilylstyrene-block-lactide), which were thermally annealed to produce perpe

202 erization and ring-opening polymerization of lactide with DBU (1,8-diazabicyclo[5.4.0]undec-7-ene), f