ライフサイエンスコーパス: lactone

1 ate substrate 3-oxo-C10 AHL (Acyl-Homoserine Lactone).

2 dihydro-6-pentyl-2H-pyran-2-one (C10 massoia lactone).

3 )-decarestrictine L, and (+)-Prelog-Djerassi lactone.

4 esents a total synthesis of (+)-trans-whisky lactone.

5 with CO to give an O-[Zr] bonded borata-beta-lactone.

6 stituents, including a five- or six-membered lactone.

7 profiling of a novel rocaglate-derived beta-lactone.

8 iomerically pure cis-epoxide to a trans-beta-lactone.

9 dization of the nitrogen of the heterocyclic lactone.

10 ta carbon atom of the alpha,beta-unsaturated lactone.

11 acid to a tosylate generated the substituted lactone.

12 ylation of the diastereomeric tricyclic beta-lactone.

13 ished by their high content of a hydrophobic lactone.

14 lization reaction, leading to a triterpenoid lactone.

15 lysates with a model probe of threonine beta-lactone.

16 argets are functionally impaired by the beta-lactone.

17 ovides an additional stereocenter within the lactone.

18 t was subsequently gelled with glucono delta-lactone.

19 e aliphatic polyesters from cyclic esters or lactones.

20 are typically difficult to achieve by ROP of lactones.

21 d into diastereomerically pure five-membered lactones.

22 lides, respectively, or to alpha-benzylidene lactones.

23 groups involve chlorogenic acids and related lactones.

24 reaction, giving rise to nine-membered-ring lactones.

25 n of ketenes to give ketene heterodimer beta-lactones.

26 e thermochemical ring opening to fused gamma-lactones.

27 s to bicyclic [3.2.1] or [2.2.2] L-iduronate lactones.

28 the novel [2.2.2] l-iduronate thioglycoside lactones.

29 lles gives good to excellent ee's of product lactones.

30 of acyclic dienyl esters to cyclohexyl beta-lactones.

31 h appropriate substitution of diacylglycerol lactones.

32 nes can lead to important four-membered beta-lactones.

33 a Kulinkovich reaction of the corresponding lactones.

34 nt stereoselective pathways afforded the two lactones 1 and 2, which are key building blocks in the s

35 Ten antifouling 14-membered resorcylic acid lactones 1-10 were isolated previously with low or trace

36 conformationally challenging seven-membered lactones (1-11); computed and experimental data sets are

37 gamma-Vinyl-gamma-lactone 1a has been contemplated as allyl electrophile d

38 dioyl-CoA, 4-hydroxyheptanedioyl-CoA, or its lactone, 2-hydroxyglutaryl-CoA, and 2-ketoglutaric acid

39 the proposed pathway from ester 6 to enamine lactone 22 and its rearrangement to amide 19.

40 ntramolecular hydrogen bond shown in enamine lactone 22.

41 onversion of ester 6 to amide 19 via enamine lactone 22.

42 action of these structures, a highly potent lactone (3) derived from 1 was identified.

43 el system composed of (3-caffeoylquinic acid lactone (3-CQAL), 4- caffeoyl quinic acid lactone (4-CQA

44 id, and 3,4-dimethoxycinnamic acid) and four lactones (3,4-O-dicaffeoyl-1,5-gamma-quinide, 3-O-[3,4-(

45 s, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm formation and

46 a produces N-(3-oxo-dodecanoyl)-L-homoserine lactone (3OC12), a crucial signaling molecule that elici

47 12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL).

48 ducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component receptor LuxN

49 ally to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserin

50 id lactone (3-CQAL), 4- caffeoyl quinic acid lactone (4-CQAL), and 4-feruloylquinic acid lactone (4-F

51 lactone (4-CQAL), and 4-feruloylquinic acid lactone (4-FQAL)) was used for the screening of enzymes

52 ethyltetrahydrofuran-3-yl)butan-2-one] and a lactone [4-hydroxy-4-methyl-3-(3-oxobutyl)-valeric acid

53 sphaerides E-H (1-4) together with one gamma-lactone (5) and the methyl ester of compound 2 (11).

54 umber of variables (14 compounds), including lactones (6-pentyl-alpha-pyrone, gamma-decalactone, gamm

55 pargylation of a highly enolizable beta-keto-lactone, a ring closing alkyne metathesis and a modified

56 g various phenolic glycosides, a monoterpene lactone, a spermine derivative, and fatty acids, could b

57 tion of a cyanophthalide with a chiral enone-lactone, a stereoselective cyclization-reduction to inst

58 y enantioselective radical dehalogenation of lactones-a challenging transformation for small-molecule

59 ounds, including esters, alcohols, terpenes, lactones, acids, carbonyl compounds, and volatile phenol

60 common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lower than the

61 es preferentially settle on N-acylhomoserine lactone (AHL) producing marine bacterial biofilms.

62 N-acyl-homoserine lactone (AHL) quorum-sensing molecules produced by gram-

63 N-acylhomoserine lactone (AHL)-based quorum sensing (QS) is important for

64 n-thermal plasma exposure on acyl homoserine lactone (AHL)-dependent quorum sensing (QS).

65 exchange of signals such as acyl-homoserine lactones (AHL) enables communication within and between

66 catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-methionine and

67 the homoserine lactone of N-acyl homoserine lactone (AHLs).

68 nge, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria.

69 stems are those that use acylated homoserine lactones (AHLs) for communication.

70 by auto-inducers, like the N-acyl homoserine lactones (AHLs) in numerous Gram-negative bacteria.

71 moserine lactone and certain acyl homoserine lactones (AHLs) were found to substitute for threonine i

72 nt of the oxidation state of the thus formed lactone allows introduction of the 2,3-dihydroxybenzoqui

73 evealed that in the case of the six-membered lactone an energetically favorable conformer adopts a ne

74 etrahydrofurans including aryl-Hagen's gland lactone analogues via intramolecular iodoetherification.

75 of horseradish roots, like (3S,3aS,7aR)-wine lactone and 3-isopropyl-2-methoxypyrazine.

76 oducts; a tricyclic N-heterocycle-fused beta-lactone and a bicyclic enamine derived from in situ deca

77 H and interconversion kinetics between TPT's lactone and carboxylate forms.

78 into procyclic forms, homoserine, homoserine lactone and certain acyl homoserine lactones (AHLs) were

79 uctures are reported for a [2.2.2] iduronate lactone and examples of both methyl L-idopyranoside and

80 show that reaction products (d-glucono-delta-lactone and hydrogen peroxide) and the wheat flour dough

81 longside plasma treated N-butyryl-homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exh

82 and acceptance in relation to sesquiterpene lactone and phenolic content.

83 Furans, lactones and acids resulting from the thermal breakdown

84 end to effect the selective ring-opening of lactones and carbonates.

85 of synthetic, non-native N-acyl l-homoserine lactones and identified compounds that can drastically a

86 The generic statement that sesquiterpene lactones and phenolic compounds are determinants of bitt

87 bolites that included sugars, sesquiterpenes lactones and phenolics in the leaf and stem parts, which

88 ption of these sensory traits in relation to lactones and phenolics were brought out.

89 iderably more thermally stable than the beta-lactones and require higher temperatures for efficient d

90 or both ring-opening polymerization (ROP) of lactones and ring-opening copolymerization (ROCOP) of ep

91 by combining ring-opening polymerization of lactones and ring-opening copolymerization of epoxides/a

92 ccharide-conjugated CTS with a five-membered lactone) and compare their characteristics and binding k

93 n (a nonglycosylated CTS with a six-membered lactone) and digoxin (a trisaccharide-conjugated CTS wit

94 inolone and N-(3-oxododecanoyl)-l-homoserine lactone, and the redox mediator pyocyanin bind with tran

95 ng expensive N-alkyl amino acids, homoserine lactones, and Agl lactams, and to achieve the mild, effi

96 s, silyl ethers, vinylogous esters, ketones, lactones, and beta-ketoesters are tolerated under the re

97 ful yields of alpha,beta-unsaturated esters, lactones, and nitriles.

98 and 2,3-dihydroxy acids, beta-hydroxy-omega-lactones, and omega-1-methyl alcohols.

99 is involved in formation of the unsaturated lactone; and the ferric-reductase-like enzyme RbtH, whic

100 Carboxylic esters, lactones, anhydrides, secondary amides, and carboxylic a

101 pure bicyclo[2.2.2]octenones, including the lactone-annulated system 26, has been prepared by engagi

102 f the biosynthetic gene cluster for the beta-lactone antibiotic obafluorin and delineate its biosynth

103 trans-beta-Lactones are a versatile and useful class of compounds,

104 These lactones are closely related to the monoterpene-limonene

105 Both [3.2.1] and [2.2.2] lactones are converted into GlcN-IdoA heparin precursor

106 The functionalized beta-lactones are formed under mild conditions in high yields

107 ible molecules, specifically acyl-homoserine lactones, are produced by P. aeruginosa to promote virul

108 sults, including the formation of a bicyclic lactone arising from oxidative termination of the photor

109 unusual architecture featuring non-canonical lactone as well as lactam rings.

110 eparation and reactivity of cyclopropylidene lactones as possible intermediates of the domino process

111 nspired by this mechanism, we exploited beta-lactones as putative mycolic acid mimics to block serine

112 approach to construct a wide range of amino lactones as well as 1,2-amino alcohol derivatives.

113 of the diastereoisomers of these p-menthane lactones, as well as their common precursor, menthofuran

114 ensing inhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dosed onto hea

115 ryostatin analogues bearing a diacylglycerol lactone-based C-ring, which possessed the requisite phar

116 rophosphonate-based probes and specific beta-lactone-based probes led to the discovery of alpha-ketoh

117 sitively regulated by an N-acyl-L-homoserine lactone-based quorum sensing system, but operating in a

118 ulted in 2,3-difunctionalized benzofuran and lactone bearing indoline-2-one scaffolds under same cond

119 for the diastereoselective synthesis of beta-lactones bearing two stereogenic centers, from disubstit

120 s- and trans-fused bicyclic gamma- and delta-lactones bearing up to four contiguous stereocenters.

121 an efficient biobased route to the branched lactone, beta-methyl-delta-valerolactone (betaMdeltaVL),

122 ce factors, by N-3-oxododecanolyl homoserine lactone binding to the quorum sensing receptor, LasR.

123 indicate immunobiological potential of these lactone bioconjugates.

124 m a common chiral nonracemic bicyclic lactam lactone (BLL).

125 ward access to a wide range of useful chiral lactone building blocks containing tetrasubstituted ster

126 d by the iPLA2gamma inhibitor, (R)-bromoenol lactone, but not by the cyclooxygenase inhibitor, indome

127 ite-selective arylation of gamma-vinyl-gamma-lactone by aryl boronic acid has been developed.

128 cids to their corresponding gamma-alkylidene lactones by the use of a heterogeneous Pd(II) catalyst s

129 es, including N-(3-oxododecanoyl)-homoserine lactone (C12), for intercellular communication.

130 t-chain AHLs, N-3-(oxododecanoyl)-homoserine lactone (C12-HSL) and N-butyryl homoserine lactone (C4-H

131 e lactone (C12-HSL) and N-butyryl homoserine lactone (C4-HSL), on cell viability and mucus secretion

132 gent C-glycosidation of carbohydrate-derived lactones can be mediated by the protecting groups and ap

133 pes of substrates including dihydrocoumarin (lactone) can be achieved.

134 vs 17 kcal mol(-1) for BTP) include its high lactone carbonyl stretching energy (1821 cm(-1) in aceto

135 we show that Withaferin A (WA), a steroidal lactone, causes a change in NEMO's interaction with spec

136 The p-menthane lactones constitute a family of powerful odorants, inclu

137 oichiometric oxidant, and provides access to lactones containing fluorine-bearing stereogenic centers

138 tudied in regard to its bitter sesquiterpene lactones content.

139 This compound has a furyl-delta-lactone core similar to that of Salvinorin A (Sal A), an

140 analytical approach we identified a fragrant lactone corresponding to an odorant zone reminiscent of

141 been hypothesized by Taylor that this unique lactone could arise from a postketidal transesterificati

142 c acids (CQAs, FQAs) and their corresponding lactones (CQALs, FQALs) in a non-selective way.

143 r esterase (HLE) hydrolyzed chlorogenic acid lactones (CQALs, FQALs) selectively, while chlorogenate

144 ation confirms stepwise electronic/inductive lactone deactivation for both BTF and BTP, the unusually

145 L-Galactono-1,4-lactone dehydrogenase (GLDH) catalyses the last enzymati

146 allowed quantitative determination of delta-lactones (delta-C8, delta-C10) and gamma-lactones (gamma

147 Withaferin A (WA), a C5,C6-epoxy steroidal lactone derived from a medicinal plant (Withania somnife

148 retofore unidentified alpha,beta-unsaturated lactone derived from dioxygenation of pyrene at an apica

149 her applied to the base-sensitive and stable lactones derived from highly functionalized iridoid deri

150 r aromatics are found to yield carboxymethyl lactones derived from the initially formed o-carboxyaryl

151 sing two sets of chemical properties (set 1: lactone, diastase activity, sucrose - 100%) (set 2: free

152 The resulting new iduronic [2.2.2] lactone disaccharides are readily rearmed by mild methan

153 he cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular str

154 The alpha-angelica lactone displays unusual regioselectivity in this reacti

155 The [2.2.2] lactone enables a scalable 3-step route from 1 to a new

156 ses ABHD10 and ACOT1/2, the most potent beta-lactone enantiomer was also found to inhibit these enzym

157 lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exhibited marked attenuation of virulence.

158 ent impact on C6 alcohols, volatile phenols, lactones, fermentation-derived alcohols, acids, or most

159 d the potential of chirospecific analysis of lactones for authentication and quality evaluation of fr

160 Monacolin K (acid form), monacolin K (lactone form) and minor monacolin peaks were separated o

161 For the calibration curve of monacolin K (lactone form), a linear correlation in the range 6-119mi

162 orces the molecule to adopt a nonfluorescent lactone form, providing a convenient method to make fluo

163 (dr from 3:1 to 32:1 for 8 examples) in beta-lactone formation.

164 eld and diastereoselectivity in racemic beta-lactone formation.

165 Although these lactone fragmentation substrates reacted somewhat less e

166 es to elaborate the highly substituted delta-lactone framework.

167 ifferent tricyclic angularly fused spiranoid lactones, frequently observed as scaffold segments of va

168 of an optically active alpha-methylene-gamma-lactone from p-chlorostyrene has been developed on the b

169 ective synthesis of N-heterocycle-fused-beta-lactones from N-linked ketoacids is described.

170 ified physapubescin, a predominant steroidal lactone, from medicinal plant Physalis pubescens L., com

171 umarin scaffold in which the carbonyl of the lactone function of the original coumarin dyes has been

172 nctional group in DHM is essential while the lactone functional group tolerates modifications.

173 a catalysts provided access to bicyclic beta-lactone-fused, N-heterocycles in moderate to good yields

174 lta-lactones (delta-C8, delta-C10) and gamma-lactones (gamma-C6, gamma-C8, gamma-C10).

175 : guaiacol, cis-whisky lactone, trans-whisky lactone, gamma-nonalactone, eugenol, vanillin, and aceto

176 o use LBA as an alternative to glucono-delta-lactone (GDL) for the production of dairy gels with a co

177 of a mixture of gelators using glucono-delta-lactone (GdL) initially triggers assembly of DBS-CO2H, f

178 The hydrolysis of glucono-delta-lactone (GdL) provides a slow pH drop that allows for st

179 Upon acidification with glucono-delta-lactone (GDL), bovine, soy and quinoa milks formed struc

180 so avoided an odor component, gamma-octanoic lactone (GOL), which is >150-fold less volatile than IPA

181 tensity was closely related to trans-whiskey lactone, guaiacol and vanillin, whereas astringency and

182 nthesis of diverse enantiomerically enriched lactones has been developed based on Cu-catalyzed enanti

183 Chlorogenic acid lactones have been identified as key contributors to cof

184 Beta-lactones have served as chemical tools to manipulate Clp

185 previously discovered that the sesquiterpene lactone helenalin acetate, a natural compound known to i

186 functional groups have been introduced into lactones; however, the direct polymerization of tertiary

187 ich do not respond to 3-oxo-C(12)-homoserine lactone (HSL)-mediated QS, exhibit reduced virulence fac

188 inosa secrete N-(3-oxododecanoyl)-homoserine lactone (HSL-C12) as a quorum-sensing molecule to regula

189 and its substrate, and discuss the possible lactone hydrolysis mechanism of VmoLac.

190 s-conformation, and the presence of a labile lactone in this core, many synthetic methodologies commo

191 investigated an approach to decompose these lactones in a selective way without affecting the positi

192 phenyl esters largely exceeded that of beta-lactones in ClpP peptidase and protease inhibition assay

193 d catalyst to produce highly enantioenriched lactones in excellent yield is reported.

194 actonization was employed, leading to a beta-lactone incorporating the requisite cis-fused 2-azadecal

195 rational efforts to design specific non-beta-lactone inhibitors have been reported to date.

196 cture elucidation of a class of novel cyclic lactone inhibitors of elongation factor 1.

197 ed to identification of the isolable enamine lactone intermediate 22.

198 obust and scalable conversion of sugar gamma-lactones into highly valuable glycosides having a quater

199 cifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts.

200 stereoselective synthesis of homocitric acid lactone is described.

201 GC-MS, we show that only the (R)-C10 massoia lactone is found in musts and wines.

202 We show that (R)-C10 massoia lactone is reduced to (R)-delta-decalactone during alcoh

203 Ring-opening polymerization of lactones is a versatile approach to generate well-define

204 Formation of delta-lactones is observed when cyclopentanone-2-carboxylates

205 lective synthesis of cyclopentane-fused beta-lactones is presented.

206 erimental chemical shifts for each of the 11 lactones, is encouragingly small (0.02-0.08 ppm for (1)H

207 ges were determined for nafithromycin, a new lactone-ketolide, following the completion of a nine-lab

208 ion furnished coumarin- or quinolinone-fused lactone/lactam derivatives.

209 natin and total indole (monatin plus monatin lactone/lactam) in mock beverage solutions, with an acco

210 ily accessible chiral starting materials and lactone-lactone rearrangement are the highlights of the

211 proximately 6 muM] properties of 16-membered lactone macrolides based on spiramycin's aglycone.

212 Although these p-menthane lactones may contribute individually to mint and coconut

213 multaneous determination of four macrocyclic lactones (ML) (abamectin, doramectin, ivermectin and mox

214 n established the last stereocenter, and the lactone moiety was formed by ring-closing metathesis.

215 Olfr1440 responds to macrocyclic ketone and lactone musk odorants but not to polycyclic musk odorant

216 beta-Lactone natural products occur infrequently in nature bu

217 and cochliomycin B (2), two resorcylic acid lactones obtained from marine sources, have been prepare

218 PCET, whereas reduction of a representative lactone occurs through a concerted PCET.

219 hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

220 time, certain fatty amides, gamma- and delta-lactones of high molecular weight, and other aromatic co

221 ying interglycosidic spirocyclic ortho-delta-lactone (orthoester) linkage between at least one pair o

222 N-3-oxo-tetradecanoyl-l-homoserine lactone (oxo-C14-HSL) primed plants for enhanced callose

223 undergo oxidative cyclization to form gamma-lactones predominantly.

224 Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory

225 Manipulation of lactone product to useful small building blocks is also

226 The major isomer of the beta-lactone products was determined to be the anti-diastereo

227 drodipyrrins: Pd-mediated coupling to form a lactone-pyrrole, Petasis reagent treatment for methenyla

228 thailandensis contains three acyl-homoserine lactone quorum sensing circuits and has two additional L

229 es C and 30 degrees C carry N-acylhomoserine lactone quorum sensing signals, as well as alkaline phos

230 ppears to bind and sequester some homoserine lactone quorum signals, resulting in the inability of P.

231 The acyl-homoserine lactone quorum-sensing (QS) systems of these three speci

232 ned to the recently reported resorcylic acid lactone (RAL) neocosmosin A has been established.

233 rs formed as byproducts, the yields of delta-lactones range from moderate to good (up to 74%).

234 Macrocyclic lactones ranging in size from twelve- to seventeen-membe

235 s, whereas the five-membered alpha-methylene lactone reacts to mixtures of regioisomers with a high p

236 ar Alder-ene (IMAE) reaction and a lactam-to-lactone rearrangement of tetracycle 13, a compound that

237 pulations involving the carbamate formation, lactone reduction and cyclization, afforded cyclopropyl

238 inolone and N-(3-oxododecanoyl)-l-homoserine lactone reporter assays, showing that Fap fibrils pretre

239 5000 members isolated to date, sesquiterpene lactones represent a prolific source of medicinal agents

240 the purees may be allocated to terpene- and lactone-rich ('SH-5'), ester-containing ('Criolla'), and

241 h alkylation/cyclization and an Ullmann-type lactone ring closure into the pentacyclic lamellarin ske

242 Sirtinol, a cell-permeable lactone ring derived from naphthol, is a dual Sirt1/Sirt

243 re both the pyrrolidine moiety and the delta-lactone ring of the 3,4-dihydrocoumarin framework are co

244 erdisarm iduronate components, reversible by lactone ring opening.

245 ither the copolymerization of a hydrolyzable lactone ring or the hydrogel polymer content.

246 amma-butyrolactone acrylate (DBA)-containing lactone ring that modulated the lower critical solution

247 a similar structure of 16-membered aglycone lactone ring.

248 t sugar units allows the formation of unique lactone rings within the CD framework via a 1,8-HAT-beta

249 one (BTF), bearing three symmetry-equivalent lactone rings, is unique in its ability to undergo highl

250 tion of homoallylic alcohols to afford delta-lactones selectively.

251 The most selective of the diacylglycerol lactones showed only a 10-fold reduction in binding affi

252 ion of a highly functionalized sesquiterpene lactone skeleton in five steps via an enantioselective k

253 the world, containing bitter sesquiterpenoid lactone (SL) compounds that may negatively affect consum

254 he first total synthesis of resorcyclic acid lactone spiroketal citreoviranol (1) is described.

255 the cation-binding site and the type of the lactone substituent determine the arrangement of alphaM4

256 olecular pinacol coupling between ketone and lactone subunits to assemble the complex skeleton of (-)

257 ble molecules, specifically acyl homo serine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lact

258 LasI is an acyl-homoserine lactone synthase that produces a quorum-sensing (QS) sig

259 ring inhibitors of LuxI-type acyl-homoserine lactone synthases.

260 Lactone synthesis facilitated the diastereoselective red

261 on of L-serine in E. coli and triacetic acid lactone (TAL) in S. cerevisiae revealed that the identif

262 s, including bioactive flavonoids, diterpene lactones, terpenoids and polysaccharides which accumulat

263 emical classes, such as aldehydes, alcohols, lactones, terpenoids, fatty aldehydes, fatty acids and h

264 used for quantitative analysis of pineapple lactones that was performed at three progressing post-ha

265 logous Pd sigma-complex of the five-membered lactone the smallest Pd/endo-beta-H dihedral angle is ob

266 ectively a five-membered ring fused bicyclic lactone, the core structure present in gracilioether F.

267 catalyzing the hydrolysis of acyl-homoserine lactones; these molecules are involved in Gram-negative

268 lization converting a carboxylic acid into a lactone through the oxidation of a tertiary C-H bond und

269 controlled asymmetric synthesis of cis-gamma-lactones through a formal [3 + 2] cycloaddition of enedi

270 iastereoselective addition of alpha-angelica lactone to beta-halo-alpha-ketoesters is reported.

271 tection via acid hydrolysis as well as a key lactone to tetrahydropyran conversion, in order to avoid

272 In addition, we linked the presence of those lactones to interesting odorant zones, reminiscent of mi

273 We present an operationally simple lactone-to-lactam transformation utilizing diverse amine

274 ompounds from oak wood: guaiacol, cis-whisky lactone, trans-whisky lactone, gamma-nonalactone, eugeno

275 ctic fermentation, in the wines from whiskey lactone treatment.

276 rticularly for the abeo-abietane tri-epoxide lactone triptolide.

277 large array of biologically active steroidal lactone triterpenoids called withanolides.

278 s, vinyl ethers, alkenes, cyclic ethers, and lactones) under practical, inexpensive, and environmenta

279 Enantioenriched lactones undergo Negishi-type cross-coupling with dimeth

280 Seven-membered lactones undergo selective SmI2 -H2 O-promoted radical c

281 s, ethyl esters, terpenes, aldehydes, acids, lactones, volatile phenols and carbonyl compounds) by GC

282 A synthesis of (+)-Prelog-Djerassi lactone was accomplished in three isolations from the kn

283 ene attached to an alpha-phenylselenyl-gamma-lactone was synthesized from (R)-glycidol.

284 y diversified alpha,gamma-substituted chiral lactones was also achieved in good yields albeit with lo

285 A new class of fluorinated lactones was prepared by the intramolecular fluorocycliz

286 esis of alpha,gamma-substituted chiral gamma-lactones was quickly achieved in a one pot sequential pr

287 Among a collection of beta-lactones, we found one hit with potent anti-mycobacteria

288 for Matsuda-Heck arylations of exo-methylene lactones were eventually applied to the synthesis of the

289 bi- and tricyclic, N-heterocycle-fused, beta-lactones were first synthesized in racemic fashion via t

290 The final lactones were obtained as single diastereoisomers, demon

291 The desired ketene heterodimer beta-lactones were obtained in good to excellent yields (up t

292 is known to produce 3-oxohexanoylhomoserine lactone which also supports trypanosome growth.

293 nS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously unexplaine

294 enetic knockouts and through the use of beta-lactones, which remain the only specific inhibitors of C

295 y-4-methyl-3-(3-oxobutyl)-valeric acid gamma-lactone], which accounted for 46%, 27%, and 20% of the o

296 situation whereby fragile substrates such as lactone will be hydrolyzed by a stronger base but will n

297 SQ) or methylquinidine (MeQd)) provided beta-lactones with high enantio- and diastereoselectivities.

298 tallinity via the copolymerization of cyclic lactones with propargyl 3-methylpentenoate oxide (PMPO).

299 three major products but with an increasing lactone yield of 33, 49, and 55% on these substrates, re

300 o cochliomycin B affords the resorcylic acid lactone zeaenol (24).