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1 educed level of intramolecular attack at the lactone ring.
2 he ether-like moieties within the artesunate lactone ring.
3 compounds by cleaving the amide bond or the lactone ring.
4 dditional hydrogen bond to the oxygen of the lactone ring.
5 sn-2 carbonyl of DAG was constrained into a lactone ring.
6 he alkyl chain between the THF rings and the lactone ring.
7 he alkyl chain between the THF rings and the lactone ring.
8 required for the synthesis of a 16-membered lactone ring.
9 thiolactone ring in place of the homoserine lactone ring.
10 a similar structure of 16-membered aglycone lactone ring.
11 mediated hydrolysis of the natural products' lactone rings.
13 particular attention to modification of the lactone ring and methylenedioxy group, were synthesized
16 ral and functional features of digoxin are a lactone ring and three digitoxose sugars attached to a s
17 B, which have an epoxide in the macrocyclic lactone ring, and C and D, which have a double bond inst
18 ching a compensating lipophilic chain to the lactone ring as an alpha-alkylidene moiety produced comp
19 xist between DLIF and digoxin at or near the lactone ring as well as in the nature of the sugars.
20 ches to vinigrol based on the involvement of lactone rings as tools for the conformational rigidifica
22 h alkylation/cyclization and an Ullmann-type lactone ring closure into the pentacyclic lamellarin ske
27 mpounds with substitutions in the homoserine lactone ring did not show evidence of binding to LuxR.
28 ously unknown function of the pro-drug, beta-lactone ring form of lovastatin to inhibit the proteasom
29 ermedius is a nonapeptide (RIPTSTGFF) with a lactone ring formed through condensation of the serine s
31 by the inwardly pointing cyclic pentapeptide lactone rings from adjacent bound ActD molecules should
33 uble bond, rearrangement of the six-membered lactone ring into a beta-lactam moiety, and final deprot
34 fore, we propose that initial opening of the lactone ring is promoted by Cys-47 through thioester for
35 a chiral pilocarpine analogue 3 in which the lactone ring is replaced by an oxazolidinone and the bri
36 e center of the acetogenin molecules and the lactone ring is terminal to a long alkyl chain, these ob
37 o each ring; an alpha,beta-unsaturated gamma-lactone ring is terminal to one of the alkyl chains.
39 one (BTF), bearing three symmetry-equivalent lactone rings, is unique in its ability to undergo highl
43 clic ring opening at pH > or =8.5, while the lactone ring of 20-O-acyl CPT derivatives remained unaff
44 it was determined by HPLC analysis that the lactone ring of a 20-O-ether derivative of CPT underwent
46 titutes a tertiary amine for the macrocyclic lactone ring of ferric enterobactin but maintains an uns
47 contrast with asimicin and parviflorin, the lactone ring of longimicin B, an asimicin analogue with
48 direct in vivo evidence that the homoserine lactone ring of LuxI-family autoinducers is derived from
50 re both the pyrrolidine moiety and the delta-lactone ring of the 3,4-dihydrocoumarin framework are co
53 1H difference NOE spectra indicated that the lactone rings of asimicin and parviflorin, the latter of
55 ly and inwardly pointing cyclic pentapeptide lactone rings of symmetry-related ActD molecules retain
57 t lactone resulted in both rearrangement and lactone ring opening, revealing that the farnesyl lacton
58 eral factors, including drug inactivation by lactone ring opening, tumor drug resistance, and toxicit
60 cid and exchange with AR-67, which undergoes lactone ring-opening, ionization, and membrane binding i
63 benzenoid and quinonoid cyclic pentapeptide lactone rings positioned in the minor groove and directe
65 efficiently catalyze formation of 6-membered lactone ring products from acyl-bound intermediates on D
66 igher DP lactonize more rapidly, but all the lactone rings rapidly open up when exposed to mild alkal
67 tiaromatic destabilization of the alpha-keto-lactone ring rendering the two structures much closer in
68 s aromaticity on enolization, the alpha-keto-lactone ring showed an unexpected and significant antiar
69 oid and quinonoid-linked cyclic pentapeptide lactone rings spanning two base-pairs in opposite direct
71 However, structures lacking the homoserine lactone ring, structures lacking the l-configuration at
72 ocaenols contain an unusual enolized oxepine lactone ring system that to the best of our knowledge is
73 amma-butyrolactone acrylate (DBA)-containing lactone ring that modulated the lower critical solution
74 othecin (SN-38), have a labile alpha-hydroxy-lactone ring that undergoes pH-dependent reversible hydr
75 rminated by antennal esterases that open the lactone rings to form physiologically inactive hydroxyac
76 a series of derivatives in which either the lactone ring was hydrolyzed or the C-9 phosphate ester w
77 the propenoyl-branched carbonyl into a gamma-lactone ring was performed (11-14) not only to derive a
78 isted of lactonization and aminolysis of the lactone ring, which ultimately furnished cyclopropanecar
79 nd to the T. thermophilus ribosome reveals a lactone ring with a conformation similar to that observe
82 t sugar units allows the formation of unique lactone rings within the CD framework via a 1,8-HAT-beta
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