ライフサイエンスコーパス: lacunar

1 likely to be lacunar if the index event was lacunar.

2 odosome belt that forms a gasket to restrict lacunar acid leakage, and (iii) basolateral chloride upt

3 We recruited 51 lacunar and 46 cortical stroke patients.

4 We compared the enhancement (leak) between lacunar and cortical patients, and associations with key

5 Beneath, the epithem is composed of a lacunar and highly vascularized parenchyma offering a di

6 ircle of Willis was strongly associated with lacunar and large brain infarcts.

7 At autopsy, lacunar and larger brain infarcts were identified, and s

8 glial signalling in white matter adjacent to lacunar and microinfarcts.

9 hite matter ischaemic lesions in the form of lacunar and microinfarcts.

10 We recruited patients with lacunar and mild cortical stroke.

11 Differences in prognosis of lacunar and non-lacunar infarction patients might suppor

12 e pattern of recurrent stroke subtypes after lacunar and non-lacunar infarction.

13 tiple stroke subtypes (e.g. atherosclerotic, lacunar and non-lacunar of undetermined etiology).

14 Similar proportions of patients with lacunar and non-lacunar stroke (16 studies, n=6478) had

15 sents differences in immune response between lacunar and nonlacunar stroke.

16 Is of unclear cause, 15 were predicted to be lacunar, and 17 were predicted to be nonlacunar.

17 ning which small deep infarcts (SDIs) are of lacunar, arterial, or cardioembolic etiology is challeng

18 relevant entity, which are defined as a non-lacunar brain infarct without proximal arterial stenosis

19 into their lumina and are penetrated by thin lacunar branches and by side lines of the venous lumen.

20 Interstitial fluid flow in the lacunar canalicular system produces focal strains at loc

21 flow through the pericellular matrix in the lacunar-canalicular porosity due to mechanical loading c

22 Solute transport through the bone lacunar-canalicular system is believed to be essential f

23 Osteocytes in the lacunar-canalicular system of the bone are thought to be

24 he characteristic anatomical features of the lacunar-canalicular system.

25 ement has been measured directly in the bone lacunar-canalicular system.

26 ructure, including the sizes of vascular and lacunar (cellular) spaces, provide useful indicators of

27 life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaph

28 scular spaces, but these did not explain the lacunar-cortical difference.

29 clastic resorption 2- to 3-fold in assays of lacunar dentine resorption, without affecting osteoclast

30 The factor most predictive of lacunar development was age less than 5 years at the tim

31 d with lacunes and the factors predictive of lacunar development.

32 A significant increase in lacunar dimensions was observed when 1% w/v sodium laury

33 We sought to distinguish lacunar from nonlacunar causes of SDIs using a gene expr

34 A 41-gene profile discriminated lacunar from nonlacunar stroke with >90% sensitivity and

35 fferentially expressed genes can distinguish lacunar from nonlacunar stroke.

36 Recurrent strokes were more likely to be lacunar if the index event was lacunar.

37 planted with human hNT neurons adjacent to a lacunar infarct 27 months after surgery.

38 ependent predictors of processing speed were lacunar infarct count and brain atrophy.

39 predictors of executive function in SVD were lacunar infarct count and diffusivity of normal appearin

40 ence risks are higher among non-lacunar than lacunar infarct patients, the risks appear not to differ

41 creening and randomisation, had brainstem or lacunar infarct, a substantial comorbid disease, an inab

42 forating artery associated with the relevant lacunar infarct.

43 nts showed evidence of no infarct; seven, of lacunar infarct; and 24, of acute cortical infarct.

44 d on brain imaging into two groups: isolated lacunar infarction (n = 47) and ischaemic leukoaraiosis,

45 on (P < 0.0005)] in comparison with isolated lacunar infarction [4.22 (95% CI 1.29-13.73), P = 0.02]

46 and for two different SVD subtypes: isolated lacunar infarction and ischaemic leukoaraiosis.

47 bral small vessel disease (SVD) causes focal lacunar infarction and more diffuse ischaemia, referred

48 ratio (P = 0.01) compared with the isolated lacunar infarction group.

49 Lacunar infarction is associated with distinct clinical

50 vessel disease (SVD) can present as isolated lacunar infarction or with diffuse white matter changes,

51 Differences in prognosis of lacunar and non-lacunar infarction patients might support distinct arter

52 ificantly greater following non-lacunar than lacunar infarction, but the difference decreased thereaf

53 We compared non-lacunar with lacunar infarction, using study-specific and summary odd

54 urrent stroke subtypes after lacunar and non-lacunar infarction.

55 for a distinct arterial pathology underlying lacunar infarction.

56 risk of cardiac death in non-lacunar versus lacunar infarction.

57 tions for gaining insights into the cause of lacunar infarction.

58 ntensities, dilated perivascular spaces, and lacunar infarction.

59 0 large-artery occlusive infarctions and 142 lacunar infarctions were identified.

60 correlate with global cognitive performance (lacunar infarctions, P = .060; acute lesions, P = .088;

61 reviewed all scans for cortical infarctions, lacunar infarctions, strictly lobar CMBs, and deep/infra

62 olved after treatment, but seven resulted in lacunar infarctions.

63 ion: 2 patients presented with small-vessel (lacunar) infarctions, whereas 1 patient presented with a

64 s (OR = 1.4, 95% CI = 1.1-1.9), multiple old lacunar infarcts (OR = 1.9, 95% CI = 1.5-2.5), and moder

65 organization of axons in tissue adjacent to lacunar infarcts and in the regions surrounding microinf

66 t-mortem brain tissue from six patients with lacunar infarcts and tissue from two patients with autos

67 We examined the influence of lacunar infarcts and white matter lesions (WML) on sever

68 Lacunar infarcts are a frequent type of stroke caused ma

69 Lacunar infarcts are commonly found in the basal ganglia

70 ts with recent (within 6 months) symptomatic lacunar infarcts from 81 centres in North America, Latin

71 olving 3020 patients with recent symptomatic lacunar infarcts identified by magnetic resonance imagin

72 timating equation models, a relation between lacunar infarcts in deep white matter and an increased s

73 er during 3 years follow-up in patients with lacunar infarcts in deep white matter and that symptom s

74 appeared to result in dementia in those with lacunar infarcts in the basal ganglia, thalamus, or deep

75 Participants with lacunar infarcts in the basal ganglia, thalamus, or deep

76 A high percentage of lacunar infarcts occur in the BG, yet the relationship b

77 sulting in ischaemic damage that ranges from lacunar infarcts to white matter hyperintensities seen o

78 Lacunar infarcts were not associated with severity or co

79 magnetic resonance imaging (MRI)-documented lacunar infarcts were randomly assigned in a factorial d

80 In axons adjacent to lacunar infarcts yet extending up to 150% of the infarct

81 37 patients had had previous small-vessel or lacunar infarcts, 576 had had cryptogenic infarcts, and

82 White matter hyperintensities (WMH) volume, lacunar infarcts, and gray matter atrophy were quantifie

83 's disease pathology or larger infarcts (ie, lacunar infarcts, and large cortical and non-lacunar sub

84 ter hyperintensity (T(2)-weighted scans) and lacunar infarcts, but no intracerebral haemorrhage.

85 hese regions to both large lesions and small lacunar infarcts, creating specific symptoms based on st

86 llary tangles (NFTs), hippocampal sclerosis, lacunar infarcts, hyaline atherosclerosis, siderocalcino

87 ippocampal sclerosis of ageing pathology and lacunar infarcts, large infarcts, Circle of Willis ather

88 cerebral amyloid angiopathy, large infarcts, lacunar infarcts, microhaemorrhage, larger haemorrhage,

89 cerebral amyloid angiopathy, large infarcts, lacunar infarcts, microinfarcts, arteriolosclerosis, per

90 As in regions adjacent to lacunar infarcts, nodal and paranodal length in white ma

91 se features can be assessed on MRI including lacunar infarcts, T2 lesion volume, brain atrophy, and c

92 differences by Hp were noted for atrophy or lacunar infarcts.

93 ascular beds could account structurally for "lacunar" infarcts.

94 Primary intracerebral haemorrhage and lacunar ischaemic stroke are acute manifestations of pro

95 s, livedo reticularis, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages),

96 bnormalities (white matter hyperintensities, lacunar lesions suggestive of ischemic infarcts, and atr

97 re pigment mottling in 27 patients (63%) and lacunar maculopathy in 3 (6.9%).

98 ast acid secretion across the ruffled border lacunar membrane, the result of mutations in the vH(+)-A

99 Genes differentially expressed between lacunar (n = 30) and nonlacunar strokes (n = 86) were id

100 participants, respectively, as follows: for lacunar, n = 23 and n = 43 (adjusted RR, 0.53; 95% CI, 0

101 types (e.g. atherosclerotic, lacunar and non-lacunar of undetermined etiology).

102 cognitive impairment (MCI) or dementia after lacunar or cortical ischaemic stroke.

103 ution X-ray nanoCT studies revealed signs of lacunar osteolysis, including increases in cross-section

104 Lacunar resorption and filamentous actin ring formation

105 oncentrations that are sufficient to inhibit lacunar resorption.

106 ssion of TSG-6 correlated with inhibition of lacunar resorption; this effect was ameliorated by an an

107 es and sodium lauryl sulfate showed that the lacunar spaces expanded significantly more and the secre

108 nce of the otherwise scattered and separated lacunar spaces in the SC.

109 mechanical waves induce the expansion of the lacunar spaces within the stratum corneum leading to the

110 ectron microscopy showed an expansion of the lacunar spaces within the stratum corneum lipid bilayers

111 Here we show that a series of lacunar spinel compounds, GaM4X8 (M=Nb, Mo, Ta and W and

112 The lacunar spinel GaTa4Se8 was theoretically predicted to f

113 proportions of patients with lacunar and non-lacunar stroke (16 studies, n=6478) had MCI or dementia

114 (HR, 1.49; 95% CI: 1.07-2.07) as opposed to lacunar stroke (HR, 0.89; 95% CI: 0.57-1.40).

115 The prevalence of dementia after lacunar stroke (six studies, n=1421) was 20% (95% CI 9 t

116 d ten white Caucasian patients with previous lacunar stroke and 50 community control subjects were st

117 INTERPRETATION: Patients with lacunar stroke and CMBs likely harbor a more advanced fo

118 Consecutive patients with lacunar stroke and confluent leukoaraiosis were recruite

119 e generalized BBB leakiness in patients with lacunar stroke and control patients with cortical ischem

120 been observed at postmortem in patients with lacunar stroke and have not been noted previously on ima

121 ith intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic small vessel disease, and h

122 chaemic leukoaraiosis, defined as a clinical lacunar stroke and leukoaraiosis on brain imaging (n = 6

123 In patients with prior lacunar stroke and relatively preserved kidney function,

124 troke, and their incidence and prevalence in lacunar stroke as a pooled proportion.

125 Patients with lacunar stroke have subtle, diffuse BBB dysfunction in w

126 We observed nine patients with lacunar stroke imaged with computed tomography and magne

127 Lacunar stroke is common (25% of ischemic strokes) and m

128 characterize cerebral microbleeds (CMBs) in lacunar stroke patients in the Secondary Prevention of S

129 Cognitive dysfunction in lacunar stroke patients may commonly be overlooked in cl

130 In this large, well-characterized cohort of lacunar stroke patients, MCI was present in nearly half,

131 cterize the neuropsychological impairment in lacunar stroke patients.

132 reased primary intracerebral haemorrhage and lacunar stroke risk.

133 ity in the basal ganglia was associated with lacunar stroke subtype (p<0.0001).

134 Age and hypertension (but not WMH or lacunar stroke subtype) were independently associated wi

135 Lacunar stroke was defined as a lacunar syndrome with in

136 thrombotic stroke, cardioembolic stroke, and lacunar stroke were associated with recurrent stroke (ha

137 ng to stroke subtype; gains in patients with lacunar stroke were best predicted by a measure of intra

138 cal and magnetic resonance imaging confirmed lacunar stroke with radiological leukoaraiosis were recr

139 ts with different stroke subtypes (including lacunar stroke).

140 lerotic stroke, 1.71 (95% CI, 0.80 to 3.63); lacunar stroke, 2.32 (95% CI, 1.48 to 3.63); and cardioe

141 lerotic stroke, 3.18 (95% CI, 1.42 to 7.13); lacunar stroke, 3.09 (95% CI, 1.86 to 5.11); and cardioe

142 of patients with acute left hemisphere, non-lacunar stroke, 40 with and 40 without insular damage; (

143 ve impairment/dementia in lacunar versus non-lacunar stroke, and their incidence and prevalence in la

144 isease is a common condition associated with lacunar stroke, cognitive impairment and significant fun

145 isk of primary intracerebral haemorrhage and lacunar stroke, directly implicate the myeloperoxidase p

146 ers in a prospective series of patients with lacunar stroke.

147 ncluding cardioembolic) ischemic stroke, and lacunar stroke.

148 duction in fairly young patients with recent lacunar stroke.

149 the microvascular and brain abnormalities in lacunar stroke.

150 tudies of 7575 patients, including 2860 with lacunar stroke; 24% had MCI or dementia post stroke.

151 syndrome of intermittent fevers, early-onset lacunar strokes and other neurovascular manifestations,

152 Lacunar strokes are a leading cause of cognitive impairm

153 severe, larger cortical strokes, except that lacunar strokes are associated with cerebral small vesse

154 nitive impairment appears to be common after lacunar strokes despite their small size, suggesting tha

155 Lacunar strokes might be less likely to affect cognition

156 Among patients with recent lacunar strokes, the addition of clopidogrel to aspirin

157 Among ischaemic stroke subtypes, lacunar strokes, which were once the commonest variety,

158 rent ischemic strokes, 71% (133 of 187) were lacunar strokes.

159 of both hemorrhagic and ischemic (including lacunar) strokes.

160 he formation of the nephrocyte diaphragm and lacunar structure, which is essential for protein uptake

161 lacunar infarcts, and large cortical and non-lacunar subcortical infarcts).

162 etic risk score was strongly associated with lacunar subtype only (odds ratio, 1.05, P = 0.0012).

163 ents with a right pure motor or sensorimotor lacunar syndrome after a subcortical stroke and eight ag

164 Lacunar stroke was defined as a lacunar syndrome with infarction <15mm in a region suppl

165 he basilar pons to determine whether pontine lacunar syndromes conform to discrete clinical entities,

166 of action of peptide modulators, including a lacunar system and multiple types of intercellular junct

167 l enhancement after gadolinium was higher in lacunar than cortical stroke patients in white matter (p

168 stroke recurrence risks are higher among non-lacunar than lacunar infarct patients, the risks appear

169 oke were significantly greater following non-lacunar than lacunar infarction, but the difference decr

170 rebral blood flow, and a higher incidence of lacunar type infarcts.

171 t difference in risk of cardiac death in non-lacunar versus lacunar infarction.

172 the OR for cognitive impairment/dementia in lacunar versus non-lacunar stroke, and their incidence a

173 one and cementum is abnormal, with irregular lacunar walls and fewer canaliculi.

174 We compared non-lacunar with lacunar infarction, using study-specific an