ライフサイエンスコーパス: lag phase

1 leased from products over time (i.e., have a lag phase).

2 y upon Bax addition, prior to the end of the lag phase.

3 interfering with molecular events during the lag phase.

4 otential as fibrillation proceeds beyond the lag phase.

5 that each residue remains exposed during the lag phase.

6 gation time is revealed by the length of the lag phase.

7 acile amyloid formation without a detectable lag phase.

8 tide WT-Abeta40, respectively) and without a lag phase.

9 ring an in-use stock and are released with a lag phase.

10 The whole kinetic curve is sigmoidal with a lag phase.

11 seeded-type aggregation process that has no lag phase.

12 sed to determine the predictive value of the lag phase.

13 bers of undifferentiated cells, and extended lag phase.

14 s and to better estimate the duration of the lag phase.

15 an significantly shorten the duration of the lag phase.

16 are formed in a process having a pronounced lag phase.

17 s possible with cells in mid-log phase or in lag phase.

18 media to fresh media led to growth without a lag phase.

19 Logarithmic growth was observed after a 1-h lag phase.

20 process characterized in vitro by an initial lag phase.

21 s characterized by a concentration-dependent lag phase.

22 of de novo fiber formation kinetics shows a lag phase.

23 with CXCR4, proceeds with a greatly reduced lag phase.

24 l oligomers in solution during or after this lag phase.

25 The addition of seeds eliminated the lag phase.

26 ignificant reduction in the duration of this lag phase.

27 ease profiles with varying burst release and lag phase.

28 related to pitting and starts after a 6-hour lag phase.

29 wth is observed, a period called the diauxie lag phase.

30 ncentrations resulted in only a delay in the lag phase.

31 gthy phase of arrested growth, the so-called lag-phase.

32 the early stages of the reaction during the lag-phase.

33 SUPA complex and significantly reduced these lag phases.

34 the conversion rates but did not affect the lag phases.

35 of 50 to 200 kilobases were detected in the lagging phase.

36 Following a prolonged lag phase (150 h), the OmcF-deficient strain developed t

37 underwent three stereotyped phases of WD: a lag phase, a fragmentation phase and clearance.

38 2) tension were characterized by an extended lag phase, a reduction in growth, and a greater accumula

39 expansion by demonstrating the presence of a lag phase-a transient period of very slow expansion with

40 nd width (W(t=0)) on arrival at the surface, lag phase adjustment to the new growth conditions (B), t

41 is added at different time points during the lag phase after amyloid formation has commenced reveal t

42 m small initial seeds controls the latent or lag phase; aggregate fissioning and subsequent spreading

43 wo phases of content leakage are observed: a lag phase and a burst phase.

44 nduced membrane damage is characterized by a lag phase and a sigmoidal transition, which matches the

45 kinetics of actin in T. gondii lacks both a lag phase and critical concentration, normally character

46 ditions elicited a very fast process with no lag phase and extensive formation of aggregates and stac

47 ocol permits steady state measurement of the lag phase and fiber conformational states of the protein

48 few days, whereas SAA2.2 shows virtually no lag phase and forms small fibrils within a few hours.

49 CheY, PhoB time traces exhibited an initial lag phase and gave apparent pseudo-first order rate cons

50 terized by a protein concentration-dependent lag phase and has characteristics of a nucleation-depend

51 intermediates that are populated during the lag phase and indicate that significant sequestering of

52 where the second transition is preceded by a lag phase and is associated with the main portion of the

53 reduced activity model better described the lag phase and microbial decay in some treatments.

54 of dioxygenase activity, albeit with a long lag phase and need for high concentrations of hydroperox

55 X-i-RGS-insensitive Galpha(oA) shortened the lag phase and restored rapid activation, but retarded th

56 close vicinity of O5 and known to extend the lag phase and retard the O2 release phase (slow phase) i

57 s of the Dd FDH-catalyzed reactions (initial lag phase and subsequent faster phase).

58 n contrast, the "B-C barrel" region shows no lag phase and the incorporation of the C-terminal residu

59 tion are used to extend the pre-steady-state lag phase and to suppress photoinhibition, thereby impro

60 main shortened the collagen fibril formation lag phase and tyrosine sulfation was required for this e

61 ifferent drug release profiles, with a 9-day lag phase and without a lag phase, respectively.

62 fibers, with more repeats leading to shorter lag phases and faster assembly rates.

63 long periods of slow growth (the so-called "lag phase") and large differences between individual cel

64 linearly over their lifetime with no initial lag phase, and that increasing expression correlates wit

65 e in the viscous component of arterial wall (lag phase angle, theta) was calculated from hysteresis p

66 Single cells in the lag phase are more likely to detach than clustered ones

67 ence for a self-catalyzed aggregation with a lag phase, as observed previously by fluorescence method

68 modest slowing as [Ca(2+)] is reduced and a lag phase at low calcium.

69 A lag phase at low protein concentrations indicates that f

70 s of early conformational steps that lead to lag phases at the beginning of the kinetics.

71 The lag phase AUC for predicting delayed emptying at 4 h was

72 Vaccination is associated with a lag phase before generation of immunity.

73 pon addition to the cells, whereas Ctn had a lag phase before inducing membrane damage and exhibited

74 unterparts, but these vectors also exhibit a lag phase before maximal gene expression.

75 However, the lag phase before progeny production is shortened as muta

76 not need to spend a long adaptive period in lag phase before resuming growth after exposure to this

77 ut with unusual kinetics that involve a long lag phase before the onset of rapid lipid mixing, and th

78 ar to act on a kinetic level, shortening the lag phase before virion production, perhaps lowering the

79 These studies revealed unexpectedly long lag phases between pH change and hemifusion.

80 ario was also associated with a considerable lag phase (between approximately one and three decades)

81 e hypaxial domain, but that after an initial lag phase, both progress at the same rate.

82 th and urine) as Ec1a, despite its prolonged lag phase (broth) or initial decrease in concentration (

83 tions remained exposed to solvent during the lag phase but less exposed than unstructured model pepti

84 otofibrils) rich in beta-structure after the lag phase but prior to the development of well-defined a

85 d if BRICHOS is added at any time during the lag phase, but it is too late to interfere at the end of

86 Phosphorylation reduced the lag phase by over 50% and thus accelerated the formation

87 much as 600%, shortening inactivation curve lag phase by up to 73% and lowering CTs required for 2 l

88 of 4-h imaging, and to determine whether the lag phase can predict delayed emptying.

89 The presence of these lag phases can bias short simulations toward selecting m

90 fficient seeds for assembly, eliminating the lag phase characteristic of a monomer-only reaction.

91 The lag phase characteristic of the slow nucleation process

92 and Deltatbp2 strains exhibited an extended lag phase compared with the wild type, although the lag

93 conditions and that dps mutants have altered lag phases compared to wild-type cells.

94 The lag-phase conformation, while considerably less ordered

95 ate production from proline occurs without a lag phase, consistent with substrate channeling and impl

96 of rapid lipid mixing, and the length of the lag phase correlates with the kinetics of peptide-induce

97 which was greatly reduced within 8 h, and a lagging phase, culminating 24 h after drug removal.

98 n, D-dimer, peak thrombin, lower Ks, shorter lag phase, decreased D-Drate, and prolonged CLT were ind

99 The highly variable lag phase depends on the speed of action of an antimalar

100 duced in which displacement is preceded by a lag-phase, directly proportional to the distance moved.

101 eration slow protein (Wld(S)) lengthened the lag phase dramatically, but neither affected fragmentati

102 ree energy barrier that is the origin of the lag phase during aggregation.

103 brillation rate of CsgA by circumventing the lag phase during nucleation.

104 methotrexate binding assays shows a distinct lag phase during these time frames for the native state.

105 he thioflavin-T assay shows a characteristic lag phase during which the nucleation of fibrils occurs

106 by lipoxygenases (LOX) is associated with a lag phase during which the resting ferrous enzyme is con

107 2-29 are involved in interactions during the lag phase, during which N-terminal residues 1-6 showed n

108 s C, clearly show the existence of a kinetic lag phase, during which short oligomers are formed, prio

109 This resulted in a 5-h lag phase, during which time little growth occurred.

110 the PES and appeared in the sorbent after a lag-phase (e.g., diazinon and diuron).

111 mpetent mice rickettsial growth manifested a lag phase early, suggesting that TLR4 may initiate innat

112 Differences were the result of a longer lag phase (entry plus differentiation) and generation ti

113 a stable population of oligomers during the lag phase, even at concentrations below the supercritica

114 The increased lag phases exhibited by the DeltabetT1 and DeltabetT1 De

115 Lag phase experiments were carried out at MoFe:Fe protei

116 cell expansion was nonlinear, with a lengthy lag phase followed by 2 days of explosive proliferation.

117 Amyloid formation normally exhibits a lag phase followed by a growth phase, which leads to amy

118 hydrolysis exhibited a delay that included a lag phase followed by a GTP hydrolysis activation step,

119 n Alzheimer's disease, is characterized by a lag phase followed by a rapid growth phase.

120 h increase in alpha-helix content during the lag phase followed by increase in beta-sheet content dur

121 er ATP release was accurately described by a lag phase followed by one or two exponential components.

122 uptake was observed in the early part of the lag phase followed by substantial water uptake at the la

123 nucleation-dependent kinetics, consisting of lag phase followed by the exponential increase in filame

124 dogenic proteins, the reaction begins with a lag phase, followed by exponential growth.

125 D variants in the presence of SsuE showed no lag phase following reduction by SsuE, and the flavin wa

126 70S ribosomes by RRF and EF-G/GTP during the lag phase for activation of ribosomes for the log phase.

127 ichroism showed that rat IAPP lengthened the lag phase for amyloid formation by human IAPP, slowed th

128 Na(+) led to a progressive shortening of the lag phase for Ca(2+) uptake.

129 , this results in a temporal decrease in the lag phase for fibril formation and a significant increas

130 These same features (no lag phase for HCO(2)H formation and a lack of equilibrat

131 se compared with the wild type, although the lag phase for the Deltatbp2 strain was less pronounced w

132 Pre-steady-state experiments indicated lag phases for Andro production from progesterone and fo

133 t from 1.04 to 0.29 s(-1) and increasing the lag phase from 12 to 19 h in RT-QuIC experiments.

134 aph theory to investigate the differences in lagged phase functional connectivity using the average r

135 tarted 6 hours after treatment initiation, a lag phase generally absent in infants and older children

136 strate the power of the package by analyzing lag phase growth with single cell resolution.

137 ion mutant (DeltaMsrA) showed a 6 h delay in lag phase growth, a 30% lower yield of H(2)O(2), signifi

138 The lag phase, growth rate, and final optical density for gr

139 activator (e.g. 65 muM) overcame a prolonged lag phase (>1 h) and unveiled a dioxygenase activity wit

140 During the lag phase, highly polydisperse, polymorph, and compact o

141 However, the lag-phase implies a substantial loss of growth during th

142 Still, the lag phase in active site generation and plasminogen acti

143 e observed in nitrite oxidation exceeded the lag phase in ammonium oxidation after anoxic periods of

144 A 6-hour lag phase in artificial pitting of artesunate-exposed iR

145 or the kinetics of fiber elongation, and the lag phase in conversion.

146 m prevention of the FBR (longer than 24h), a lag phase in dexamethasone release between days 1 and 10

147 that higher O(2) concentration shortens the lag phase in eLOX3, although it reduces the rate of hydr

148 Although insulin exhibits a pH-dependent lag phase in fibrillation, the A chain formed fibrils wi

149 of ICP27 leads to a suboptimal quantitative lag phase in gene expression but without consequence for

150 We probed the intermediate steps during the lag phase in HIV-1 IIIB Env-mediated fusion with Leu3-a,

151 mutant forms amyloid with an 18-fold longer lag phase in homogeneous solution.

152 rmediate whose presence we infer from a fast lag phase in interrupted refolding experiments.

153 show increased enzyme activity, a decreased lag phase in kinetic assays, and growth defects in vivo.

154 Deletion of the nat gene caused an extended lag phase in M. bovis BCG and a cell morphology associat

155 Characterizing the lag phase in microbial growth curves has importance in f

156 The exploitation of a lag phase in nitrate production after anoxic periods is

157 An in-depth study of the actual lag phase in nitrate production after short anoxic perio

158 say, we established that Syk demonstrates no lag phase in product formation.

159 genomic and physiological analyses of a 2-h lag phase in Salmonella enterica serovar Typhimurium.

160 Because the lag phase in sigmoidal fibril assembly kinetics is domin

161 We also found that the lag phase in the aggregation of soluble species is affec

162 The initial lag phase in the evolution of HVR1 in the infected recip

163 ined by a variety of techniques show a clear lag phase in the formation of amyloid fibrils.

164 a seed and shorten the nucleation-associated lag phase in the kinetics of amyloid formation in vitro.

165 Methanogenesis generally exhibited a lag phase in the mineral soils that was significantly lo

166 an unstructured monomer during the extended lag phase in the presence of BRICHOS.

167 m yeast (YPDC, EC 4.1.1.1) exhibits a marked lag phase in the progress curves of product (acetaldehyd

168 ependence of NmFic activity and a pronounced lag phase in the progress of target adenylylation.

169 f the blebbing activity and accounts for the lag phase in the spreading of blebbing cells.

170 The lag phase in the unwinding progress curve was reduced fo

171 ed on this variant: (1) The variant exhibits lag phases in the product formation progress curves, whi

172 ncentration and pH dependence of a preceding lag phase indicates weak Mn(II) binding.

173 limitation, yet detectable after an extended lag phase, indicating the presence of a secondary K(+) t

174 e time scale of simulation proceeds past the lag phases into a single exponential region.

175 The seeded lag phase is eliminated by a time delay before the intro

176 rization of the species populated during the lag phase is experimentally challenging, but is critical

177 The lag phase is generally thought to be a period during whi

178 Understanding factors determining this lag phase is important for drug development.

179 sensitivity at 4 h than at 2 h and that the lag phase is not predictive of delayed emptying.

180 With wild-type SsuD a lag phase is observed following the reductive half-react

181 crease in the time course of the aggregation lag phase is observed for the truncated protein.

182 from the very beginning of the reaction; no lag phase is observed for TpTSO(2)(-) formation.

183 It therefore remains unexplained why the lag-phase is adaptive.

184 ex can be determined from an analysis of the lag phase kinetics and is in good agreement with thermod

185 this regime showed that rapid emergence from lag phase led to greatly increased fitness.

186 During the lag phase, less than 20% of liposomal contents are relea

187 us derived polar lipids), with no measurable lag phase (<30 s), indicating that the FFA pool supplyin

188 Longer lag-phases may pose problems when calculating time-weigh

189 rotected axons, indicating that later in the lag phase, mitochondrial transport is not required for a

190 liposomes to added Bax, and MOMs displayed a lag phase not observed with liposomes.

191 at favor the S state were found to undergo a lag phase, not observed with the wild type, that delayed

192 The lag phase observed in nitrite oxidation exceeded the lag

193 e the thermodynamics of binding, nor can the lag phase observed in the time course of hydrolysis of l

194 Lag phase occurred during the first 2 days postinfection

195 t on phenotypic heterogeneity during various lag phases occurring in microbiology and biotechnology a

196 mediated by HIV-1 IIIB Env is preceded by a lag phase of 15-20 min.

197 Aggregate formation follows a lag phase of 2-3 d, followed by formation in axons by da

198 lated at low density, the cultures display a lag phase of 3-5 days, a phase of rapid exponential grow

199 ets is preceded by Ca(++) elevations, with a lag phase of 33 +/- 9.5 s.

200 as observed within 24 hours after an initial lag phase of 6 to 8 hours.

201 AA1.1 exhibits an oligomer-rich fibrillation lag phase of a few days, whereas SAA2.2 shows virtually

202 expression of microRNA-155 (miR-155) after a lag phase of about 4 h.

203 The cultures displayed a lag phase of about 5 days, a log phase of rapid growth o

204 or this function, the effect of PA700 on the lag phase of aggregation, and the temporal specificity o

205 ric intermediates that accumulate during the lag phase of amyloidogenesis are generally toxic, but th

206 Since antibodies to Dkk-1 also increased the lag phase of an osteosarcoma line that expressed the gen

207 0 microM isoproterenol for 5 min exhibited a lag phase of approximately 5 min, after which dephosphor

208 e conditions are characterized by an initial lag phase of duration tau that is followed by the pseudo

209 hereas it did not affect the duration of the lag phase of formation, with the exception of acetaldehy

210 t presence of NHDC significantly reduces the lag phase of growth and enhances expression of specific

211 to amastigote differentiation and during the lag phase of growth of epimastigotes (within 12--24 h).

212 G117N mutant, triggers osmotic lysis in the lag phase of growth.

213 The effects of salts on the growth phase and lag phase of IAPP amyloid formation are strongly correla

214 le to retard phagosome maturation during the lag phase of intracellular growth.

215 ngs but also caused a marked increase in the lag phase of laboratory-grown cultures, indicating that

216 label rapidly appeared in fatty acids with a lag phase of less than 2-3 min.

217 > stable transition, beta-strand 5A, shows a lag phase of nearly 350 s.

218 the first exponential growth phase, a short lag phase of nongrowth is observed, a period called the

219 y into Thioflavin T-positive fibrils after a lag phase of over 20 h, indicating nucleation-dependent

220 Specifically, the lag phase of polymerization showed only modest dependenc

221 AT-III present, factor VII both extended the lag phase of the reaction and depressed the rate of thro

222 crystallin, which is a mild modulator of the lag phase of the variant fibrillogenesis, potently inhib

223 compounds but shortened the duration of the lag phase of their formation.

224 Factor VII (10 nmol/L) extended the lag phase of thrombin generation initiated by 100 pmol/L

225 d transgene expression is characterized by a lag phase of up to 6 weeks.

226 After a lag phase of variable duration, wild-type variants emerg

227 rs) revealed iso-alkane biodegradation after lag phases of 900-1800 and ~280 days, respectively, befo

228 Instead, as suggested by increased lag phases of ArcA overexpression strains, respiratory e

229 milar concentrations of oligomers during the lag-phase of the aggregation of wild-type and mutated al

230 ated polymerization-type aggregation, with a lag phase (of approximately 150 h) followed by a growth

231 T were associated with faster formation (-9% lag phase) of denser fibrin networks (-12% fibrin clot p

232 tors that can matter, like the impact of the lag phase on the tolerance to stress, or the appearance

233 The reaction starts with a lag phase period when partial Mo(VI) centers of molybdat

234 channel currents displayed: (1) a prominent lag phase preceding activation, (2) retarded activation

235 together with a significant increase in the lag phase preceding plasma lipid oxidation.

236 er solution, E. coli PI-7 displayed a longer lag phase prior to decay and a longer half-life compared

237 ced initial concentrations lead to shortened lag-phases, probably due to reduced need for bacterial g

238 The study of lag phase promises to identify the physiological and reg

239 ensitive to events taking place early in the lag phase promoting the assumption that only monomeric o

240 fectants (designated RII Cl 37) had a longer lag phase relative to NEO-transfected control cells (des

241 Lag phase represents the earliest and most poorly unders

242 ofiles, with a 9-day lag phase and without a lag phase, respectively.

243 stable, it polymerizes more favorably with a lag phase shorter than ATP-actin and a critical concentr

244 After a 1-3days lag phase, skin fermentation caused a constant increase

245 fluorescence is used to probe the nature of lag-phase species populated during the formation of amyl

246 starved for niacin, it exhibits an extended lag phase, suggesting a central role for the transporter

247 that are rapidly induced at the beginning of lag phase, suggesting a mechanism that involves de novo

248 w that glutamate production occurs without a lag phase, suggesting that the intermediate, Delta(1)-py

249 eaker forms of synchronisation (almost, time-lag, phase synchronisation, and generalised synchronisat

250 HuPrP(120-144) has a shorter aggregation lag phase than BVPrP(120-144) followed by SHaPrP(120-144

251 The wild type grew with a shorter lag phase than RG21 at either pH 10.5 or 11 and under ei

252 The transcriptional p53 program had a longer lag phase than the rapid mitochondrial p53 program.

253 The yihI deletion strain showed a shorter lag phase than wild-type strain, suggesting that YihI ma

254 ys concentration and length dependence and a lag phase that can be abbreviated by seeding.

255 tion process, where PrP(b) exhibits a longer lag phase that cannot be completely eliminated by seedin

256 f various kinds of protein aggregates in the lag phase that disappear concomitantly with a rise in th

257 completely unwound DNA displayed a distinct lag phase that increased with duplex length, reflecting

258 nitoring Cy3 fluorescence display a distinct lag phase that increases with increasing duplex DNA leng

259 The first is a lag phase that is caused in part by the concentration-de

260 talyzed peroxidase reactions show an initial lag phase that is consistent with the in situ conversion

261 This was characterized by a ca. 1.3 s lag phase that is explained by the number of Fe protein

262 course of Ca(2+) uptake did not display the lag phase that reflects allosteric Ca(2+) activation of

263 adily, whereas those of Cd showed an initial lag phase that we explain by a change in the efficiency

264 E180Q, D187N, and Y10F have shorter kinetic lag phases that represent the change from CatD(hi) to Ca

265 akes the novel prediction that following the lag phase the population expands at a constant rate inde

266 faster the rate of aggregation (shorter the lag phase), the less effective the sHsps were at inhibit

267 During the lag phase, the RS-1 cells gave rise to a new population

268 growth mechanism is proposed to explain this lag phase: the {Mo(72)Fe(30)} macroanions slowly associa

269 We found that as the cultures leave the lag phase, they secrete high levels of dickkopf-1 (Dkk-1

270 the addition of Fe2+ alone extended the 15-h lag phase to 25 h.

271 lets showed reduced aggregation and a longer lag phase to collagen.

272 e Fe2+ adversely affects the transition from lag phase to log phase, perhaps through increasing oxida

273 The main lag-phase transcriptional program initiated at 20 min wi

274 ished concept of metabolic adaptation in the lag phase, two stable cell types with alternative metabo

275 The high concentration of iron during lag phase was associated with transient sensitivity to o

276 The lag phase was developmentally regulated, becoming shorte

277 hat in the wild type and the duration of the lag phase was increased.

278 The lag phase was not found in polymer assembly, suggesting

279 Upon ATP addition, a distinct lag phase was observed before the triplex-forming oligon

280 ples incubated with antibiotics, a prolonged lag phase was observed compared with controls (P <0.05).

281 A lag phase was observed for DT but, with Ti(III) product

282 f glycine, L-serine was reacted with ALAS, a lag phase was observed in the progress curve for the L-s

283 continuous release of dexamethasone, with no lag phase, was necessary to prevent inflammation in mini

284 ions that were poised at various potentials, lag phases were observed prior to reaching steady-state

285 before the onset of methanogenesis, although lag phases were shorter with n-alkanes (~650-1675 and ~1

286 eiomorphic cell shape and a prolonged, 4-6 h lag phase when grown in human urine.

287 er transcriptional reprogramming and shorter lag phases when the cells need to shift to alternative c

288 clearance rate excludes the highly variable lag phase, when the parasitemia level may increase, rema

289 e plants strongly affected the length of the lag phase, which could be attributed to different specie

290 that of carboxyl ester lipase, after a long lag phase, which could be eliminated by the addition of

291 ction in ECAO activity and the presence of a lag phase, which could be overcome under oxygen saturati

292 Fucoidan-induced platelet activation had a lag phase, which is reminiscent of platelet activation b

293 Reaction showed a pronounced lag phase, which suggested that eLOX3 is deficient in it

294 Typhimurium during lag phase, while levels of cobalt, nickel, and sodium sh

295 sing simulated evolution we predict that the lag-phase will evolve depending on the distribution of c

296 e switching is less frequently required, the lag-phase will evolve to be longer whereas, in frequentl

297 as, in frequently changing environments, the lag-phase will evolve to be shorter.

298 an oligomeric intermediate forms during the lag phase with parallel beta-sheet structure in a region

299 (<600 nm in length), form rapidly without a lag phase, with a maximum rate at pH 3.5.

300 ystem that it is not possible to shorten the lag-phase without incurring a permanent growth-penalty.