ライフサイエンスコーパス: lag

1 After a 1-3days lag phase, skin fermentation caused a constant increase

2 T were associated with faster formation (-9% lag phase) of denser fibrin networks (-12% fibrin clot p

3 A lack of resources for research and a lag in policy implementation slows down intervention str

4 RR)=1.14 (95% CI: 1.02, 1.27; p=0.024) for a lag of 2 wk; the estimated risk increased successively b

5 pon addition to the cells, whereas Ctn had a lag phase before inducing membrane damage and exhibited

6 leased from products over time (i.e., have a lag phase).

7 Indeed, a lag of time between the introduction and detection often

8 in vitro These results show that there is a lag between viral recrudescence and the boosting of ADCC

9 leaf area during the stress period and for a lagged recovery window thereafter.

10 Previous work has not addressed lags between transitions that represent delays in energy

11 related to leaf demography), and allocation lags between leaf and wood, dominated equatorial Amazon

12 nal consequences of many genetic alterations lags, investigators and sponsors struggle with choosing

13 for food and drug allergy or for anaphylaxis lag behind.

14 ects at the country level for cumulative and lag effects for each type of heat wave definition.

15 nding to a multilayer geometry; the flux and lag time are affected when the lipid transbilayer diffus

16 is located in the lipid layers; the flux and lag time of diffusion through a brick-and-mortar geometr

17 (MGN), variability in proteinuria levels and lag between these changes and acceptable end points, suc

18 climatology of the coincidence, overlap, and lag in space and time of their extremes.

19 ease profiles with varying burst release and lag phase.

20 ether, increased variance in temperature and lag effects interacted with a changing mean to reduce th

21 that changes in temperature variability and lag effects can alter trends in plant responses to a war

22 ms leading to Pentapetalae and asterids, and lagged behind the gamma hexaploidization.

23 damage and consequent chromatin bridges and lagging chromosomes in anaphase, frequently leading to c

24 that are aimed at reconstituting leading and lagging strand DNA synthesis separately and as an integr

25 bubble where asynchrony between leading and lagging strand synthesis leads to accumulation of long s

26 on, it is likely that TLS on the leading and lagging strand templates is unique for each strand.

27 current understanding of TLS on leading and lagging strand templates, and propose testable hypothese

28 verage rates of DNA synthesis on leading and lagging strands are similar, individual trajectories of

29 origin activation; synthesis of leading and lagging strands by the three replicative DNA polymerases

30 anism in which synthesis of both leading and lagging strands is frequently interrupted.

31 Pol delta, that function on the leading and lagging strands, respectively.

32 bited similar elongation between leading and lagging strands.

33 ule analysis, we establish that leading- and lagging-strand DNA polymerases function independently wi

34 sumed that DNA synthesis by the leading- and lagging-strand polymerases in the replisome must be coor

35 Here we show that Rad53 couples leading- and lagging-strand synthesis under replication stress.

36 mechanisms for coordination of leading- and lagging-strand synthesis.

37 fork, reflecting their roles in leading- and lagging-strand synthesis.

38 thout requiring coordination of leading- and lagging-strand synthesis.

39 and other proteins to copy the leading- and lagging-strand templates at rates between 1 and 2 kb min

40 ovements cause the DNA strand separation and lagging-strand extrusion.

41 iretrovirals (ARVs) is a lengthy process and lags considerably behind drug development in adults.

42 physical and biogeochemical transitions and lags during the vernal window period and to understand h

43 Droughts did not cause inter-annual lag effects on ER in this rich fen, as has been observed

44 n FCH4 , but droughts caused no inter-annual lag effects on FCH4 .

45 ttle of this work has addressed the apparent lag of animal diversification and atmospheric oxygenatio

46 nding of why ethnic minority populations are lagging behind.

47 events, fundamental knowledge in these areas lag behind our current understanding of neuroprotection

48 heat waves defined by minimum temperature at lag 0 (RR = 1.09; 95% CI: 1.02-1.17), and ED visits for

49 s defined by maximum apparent temperature at lag 0 [relative risk (RR) = 1.15; 95% confidence interva

50 heat waves defined by maximum temperature at lag 1 (RR = 1.02; 95% CI: 1.00, 1.04).

51 heat waves defined by average temperature at lag 1 (RR = 1.10; 95% CI: 1.00-1.21).

52 creased risk of emergency hospital visits at lag 0-2 days (cumulative relative risk [RRs] 1.011 [95%

53 performance was found at an average auditory lag of 100 ms, but this varied widely between individua

54 ED visits and either the 3-d moving average (lag 0-2) of OP(DTT) or same-day OP(DTT).

55 were observed, but only for polymeric beads: lag times correlated negatively with contact angle of wa

56 Our knowledge of actinide chemical bonds lags far behind our understanding of the bonding regimes

57 ive Cu(I) sites at the opening of the bundle lags behind the main core, and the two least accessible

58 eed among all electrical energy devices, but lag behind in energy density.

59 sin paleoclimate is linearly related to, but lagged, the 23,000 yr precession cycle in northern hemis

60 ppresses the loss of telomeres replicated by lagging-strand synthesis by a yet to be defined mechanis

61 logical and physicochemical characterization lags behind.

62 of the life-cycle impacts of these chemicals lags considerably.

63 tion models (SDMs), but applications clearly lag behind model development.

64 ly dynamic process of shifting CTL clonality lagging in tandem with viral evolution and suggest that

65 halaya, with 45.0% (40.1-50.0), consistently lag behind the rest of the country.

66 These results show that CTLs constantly lag epitope mutation, suggesting that preventing HIV-1 e

67 income groups; however, low-income counties lagged behind high-income counties by 4.3 (95% CI, 3.1-5

68 Cross-lagged panel and mediation analysis models were used.

69 Cross-lagged panel models and linear mixed-effects models were

70 nt use for eczema at age 2 months, and cross-lagged modeling showed no consistent results for disease

71 ariable linear regression analyses and cross-lagged modeling.

72 race, gender, and follow-up years, the cross-lagged path coefficient of BMI --> insulin (beta = 0.326

73 acile amyloid formation without a detectable lag phase.

74 sufficient symptoms needed for its diagnosis lags behind.

75 Sensitivity analysis using different lag times and kernel density bandwidths were tested to e

76 exposure classifications to model differing lag times between NSAID exposure and cancer development.

77 of altered biotic interactions and dispersal lags to plant community turnover along an elevational gr

78 evidence for three types of lag: "dispersal lags" affecting plant species' spread along elevational

79 An analysis based on a distributed lag model (DLM) can yield estimates of a critical window

80 Bayesian distributed lag interaction models identified a critical window of e

81 We used Bayesian distributed lag interaction models to identify sensitive windows for

82 We implemented Bayesian-distributed lag interaction models to identify sensitive prenatal wi

83 In distributed lag models, both cord blood and placental telomere lengt

84 We used distributed lag models and over-dispersed generalized linear models

85 gh (>10.0 inches) snowfall using distributed lag regression models.

86 p DAF-3 binding element required for the DTC lag-2 reporter response to the environment and to DAF-7/

87 mes more mismatches produced in cells during lagging strand replication compared with the leading str

88 and cooperative interaction with FEN1 during lagging-strand synthesis may serve to regulate sequentia

89 e high the previous year or 2 years earlier (lag effects), further reducing the expected advance over

90 NA from primer synthesis in initiating early lagging-strand polymerase recycling.

91 along elevational gradients, "establishment lags" following their arrival in recipient communities,

92 mpared to declining species, which exhibited lags relative to changes in climate.

93 al in recipient communities, and "extinction lags" of resident species.

94 ubstantially to establishment and extinction lags, yet impacts of biotic interactions on range dynami

95 il morphologies and produce eightfold faster lag times and fourfold less stochasticity than in previo

96 t synthesis, with important implications for lagging strand DNA synthesis.

97 DNA polymerase delta is required for lagging-strand synthesis, but surprisingly also plays a

98 As micronuclei formed from lagging chromosomes also activate this pathway, recognit

99 Funding lags well behind amounts needed to protect all those at

100 We find that repair of genomic lagging strand mismatches occurs bi-directionally in E.

101 cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discov

102 However, species with greater lags have not yet declined more in abundance.

103 systems, but the development of anolytes has lagged far behind that of catholytes due to the major li

104 that cause autosomal recessive ID (ARID) has lagged behind, predominantly due to non-availability of

105 Historically, such a capability has lagged for many reasons, including in particular the unc

106 ogen halide (HX) surrogates in catalysis has lagged behind considerably.

107 of human induced pluripotent stem cells has lagged behind their use.

108 ansmembrane conductance regulator (CFTR) has lagged behind research into the NBD1 domain, in part bec

109 rehensive mapping of cancer dependencies has lagged behind and the discovery of therapeutic targets f

110 ut open-source sharing of device designs has lagged behind sharing of other resources such as softwar

111 ever, our understanding of sRNA function has lagged behind their identification due to a lack of tool

112 like histone actyltransferase inhibitors has lagged behind.

113 ow genetic mixture promotes invasiveness has lagged behind documentation that such mixture commonly o

114 nergies, computing entropies of proteins has lagged far behind.

115 ontologies or hierarchical vocabularies, has lagged.

116 ltage and calcium signaling in bacteria have lagged due to their small size and a lack of sensitive t

117 excited-state organometallic catalysts have lagged far behind.

118 However, genome resources for cowpea have lagged behind most other major crops.

119 d chalcogenide (PbE; E = S, Se, Te) QDs have lagged behind those of, for instance, II-VI semiconducto

120 MPAs are increasing, but MPA implementation lags in many human-dominated regions.

121 it from MII, there is a dramatic increase in lagging chromosomes and an inhibition of cytokinesis.

122 These encounters increase mutagenesis in lagging-strand genes, where replication-transcription co

123 Variation in lags is explained by variation among species in physiolo

124 Instead, as suggested by increased lag phases of ArcA overexpression strains, respiratory e

125 val of eastern breeding species increasingly lagged behind green-up, whereas in the west-where green-

126 Pre-steady-state experiments indicated lag phases for Andro production from progesterone and fo

127 dation, and lymphoid hyperplasia; indicating lagged unfavorable effects of early postnatal SHS exposu

128 This lengthening of individual lags and of the entire vernal window carries important c

129 talyzed peroxidase reactions show an initial lag phase that is consistent with the in situ conversion

130 y relies on manual efforts, which invariably lag behind the increasingly automated generation of biol

131 : The fate of twins in sub-Saharan Africa is lagging behind that of singletons.

132 pment of clinically effective antibiotics is lagging.

133 h, but the development of a K-ion battery is lagging behind because of the higher mass and larger ion

134 lopments in AM, the 3D printing of optics is lagging due to the limits in materials and tight require

135 garding their spatiotemporal organization is lagging behind.

136 On the other hand, jet lag impacted both home and away defensive performance.

137 Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h e

138 and circadian misalignment (i.e., social jet lag).

139 Surprisingly, we found that jet lag impaired major parameters of home-team offensive per

140 model predicts that ameliorating social jet-lag is more effectively achieved by reducing evening lig

141 iming and circadian rhythmicity ('social jet-lag').

142 cadian rhythm-sleep disorders and social jet-lag.

143 confounding variables, we observed that jet-lag effects were largely evident after eastward travel w

144 investigate the concurrent and dynamic, lead-lag relationships among frontoparietal SC, FC, and reaso

145 For motility, a leading-lagging cell polarity is established that is inverted du

146 o a replisome capable of coordinated leading/lagging strand DNA synthesis.

147 taneous with one another and had zero-length lags, such as snowpack disappearance, rapid soil warming

148 er solution, E. coli PI-7 displayed a longer lag phase prior to decay and a longer half-life compared

149 fter periods of high precipitation at longer lag times (2-4 years) likely due to predation and other

150 paired mRNA export and also generated longer lag times when glucose or raffinose was replaced by gala

151 Growth reductions at longer lags were more pronounced at drier sites, where conifers

152 er winters with less snow resulted in longer lags and a more protracted vernal window.

153 C and that sequestration of PyC can markedly lag its production.

154 rends, and that geographic distributions may lag behind rapid climate change.

155 species turnover in future communities might lag behind simple expectations based on species' range s

156 le (0.25) was by myeloperoxidase over a 2-mo lag.Of the 3 fecal biomarkers studied, 2 that related to

157 loperoxidase (62.79; P < 0.0001) over a 3-mo lag and moderately so for neopterin (13.97; P = 0.0074).

158 We modeled lags as a function of both winter coldness and snow dept

159 ative bacterial pneumonia episodes (12 month lag only; p trend=0.0004).

160 are consistent with the known 3- to 6-month lag in recovery of specific immunity to CMV after initia

161 parate models for each time-updated 12 month lagged, 24 month simple moving average cumulative exposu

162 conversion to abasic sites ahead of nascent lagging strand DNA synthesis and subsequent bypass by er

163 ast, although Pol delta contacts the nascent lagging strands of active and stalled forks, it binds to

164 By counteracting MglA near lagging cell poles, PlpA reinforces the polarity axis of

165 and climate change spans a gradient from no lags to strong lags.

166 The no-lag hypothesis is the foundation of many ecophysiologica

167 There was fair consistency in the notable lags between turbidity measurement and AGI identificatio

168 in the private sector and case notification lagged behind diagnostic confirmation in the public sect

169 F-7/TGFbeta signaling promotes expression of lag-2 in the DTC in a daf-3-dependent manner.

170 We review evidence for three types of lag: "dispersal lags" affecting plant species' spread al

171 rora B through Chk1, preventing formation of lagging chromosomes.

172 ic checkpoint, and an increased frequency of lagging chromosomes during mitosis.

173 Chromatin promotes the regular priming of lagging-strand DNA synthesis by facilitating DNA polymer

174 itions (2090-2100) to facilitate analysis of lags between warming and changing CCC.

175 Indeed, the magnitudes of lags, and the relative importance of the different facto

176 s segregate with either telomeres leading or lagging in equal frequency and are preferentially associ

177 y-specific heat wave-mortality relation over lags of 0-10 d.

178 to estimate the cumulative effects of ozone (lagged over 0-3 d) on mortality in each city, and we use

179 easonal variability, and an increase in peak lag times with increasing body size.

180 nger prediction, phase slope index and phase lag analysis corroborate this directional coupling.

181 ate the synchronisation properties and phase lag between different groups of susceptible and infected

182 d increased interhemispheric coupling (phase lag index) that was more widespread at rest than during

183 isual fidelity, reducing the photoconversion lag is much more important than improving the regularity

184 r of <2.5 mum [PM2.5] or 2.5-10 mum [PM10]), lag, and outcome, and presented them as excess relative

185 ncentration and pH dependence of a preceding lag phase indicates weak Mn(II) binding.

186 he 3' ssDNA strand, but not on the putative 'lagging' AdnA ATPase.

187 Nucleation rates (lag time) also correlated with bead mass, but only for n

188 e following decades, but biological recovery lagged behind chemical recovery.

189 CARM1 recruitment lags behind the binding of SRC-3 and p300 to ER.

190 a safe and effective therapy, but VA results lag behind the results for anti-VEGF therapies.

191 wareness in the CSE tradition, or resumption lag (time to resume an interrupted task) in the applied

192 ve (FFR) to guide coronary revascularization lags despite robust supportive data, partly because of t

193 ung adult patients with soft tissue sarcomas lag behind those of children diagnosed with histological

194 This seasonal lag relationship has implications for sea ice prediction

195 nite element analysis, the generalized shear-lag theory and the fracture mechanisms.

196 pecies increased with precipitation at short lag times (1-1.5 years) likely due to enhanced food avai

197 n, D-dimer, peak thrombin, lower Ks, shorter lag phase, decreased D-Drate, and prolonged CLT were ind

198 A significant lag period and lower activity were measured when tyrosin

199 m fluctuations in wetness caused significant lag effects on FCH4 , but droughts caused no inter-annua

200 There were significant lagged effects up to 3 days with Alternaria, Leptosphaer

201 Simple lag hypotheses have become prominent in disequilibrium e

202 try, analytical chemistry appears singularly lagging behind in India despite the commendable growth i

203 ar hospitalizations were highest for smaller lag times, whereas effect estimates for respiratory hosp

204 M careers, yet students in the United States lag behind other countries, ranking 35th in mathematics

205 semblies based on carbon nanomaterials still lag behind their individual one-dimensional building blo

206 However, proteomics still lag behind genomics in popularity and ease of use.

207 and reliability of current methods are still lagging far behind human performance.

208 ld of RNA structural bioinformatics is still lagging behind; for example, current molecular graphics

209 ormation into practical application is still lagging far behind.

210 Although medicine still lags behind other fields in achieving data sharing's ful

211 ange spans a gradient from no lags to strong lags.

212 limited resolution, while numerical studies lag more than eight orders of magnitude behind experimen

213 plant community changes could substantially lag behind climatic changes, hindering our ability to ma

214 ssembly processes in real-time substantially lags behind.

215 T pathway preferentially occurs at telomeric lagging strands leading to heterogeneous telomere length

216 ted preferential elongation of the telomeric lagging strands, whereas telomerase positive cells exhib

217 anding of the spatial variation and temporal lags in microbial responses created by historical rainfa

218 ing thermal effects were more important than lagged thermal effects and disease progression increased

219 vity of Pol epsilon is compromised more than lagging-strand polymerase Pol delta at low dNTP concentr

220 The architecture suggests that lagging-strand extrusion initiates in the middle of the

221 The lag period between induction of total PP or PP/Trp53 KO

222 for direct interaction between DAF-3 and the lag-2 promoter.

223 and height growth tended to decrease as the lag between the fire year and the recruitment year incre

224 brillation rate of CsgA by circumventing the lag phase during nucleation.

225 Although a comprehensive source of data, the lag between demographic changes and their appearance in

226 ric intermediates that accumulate during the lag phase of amyloidogenesis are generally toxic, but th

227 a stable population of oligomers during the lag phase, even at concentrations below the supercritica

228 During the lag phase, highly polydisperse, polymorph, and compact o

229 tors that can matter, like the impact of the lag phase on the tolerance to stress, or the appearance

230 Due to the lag in development of the electronic effects along the r

231 The lagging-strand polymerase sometimes recycles to begin th

232 , DNA synthesis progresses further along the lagging strand than the leading strand, resulting in the

233 ed during replication of the leading and the lagging DNA strands were reported in yeast and in human

234 of the mutations between the leading and the lagging strands.

235 lix disassembly and substrate release at the lagging end.

236 annealing synthetic oligonucleotides at the lagging strand of DNA replication.

237 eplication forks at the junction between the lagging parental strand and the unreplicated DNA parenta

238 myces cerevisiae polymerase (Pol) delta, the lagging strand DNA polymerase.

239 3, 4, 6, and 7, but not 2 and 5, engage the lagging strand with an approximate step size of one base

240 tion fork structures containing a gap in the lagging strand as short as 15 nucleotides, suggesting th

241 larly damaging for cells with defects in the lagging-strand DNA polymerase delta.

242 e of these polymerases in replication of the lagging and the leading strands in human cells, respecti

243 o explain some controversial features of the lagging-strand replication.

244 ation length of the discharge ignited on the lagging electrode, causing an imbalance in the generated

245 of RNA primer-primase complexes left on the lagging ssDNA from primer synthesis in initiating early

246 amp machinery directs quality control on the lagging strand and CMG enforces quality control on the l

247 ired for Exo1 5'-exonuclease activity on the lagging strand daughter DNA, but its DNA binding activit

248 es Exo1-mediated exonuclease activity on the lagging strand DNA by facilitating Exo1 loading onto a s

249 hesize DNA and repair discontinuities on the lagging strand of the replication fork.

250 s to specific G-rich/G4 motif located on the lagging strand template for DNA replication and supports

251 der specifically inhibits Pol epsilon on the lagging strand, and CMG protects Pol epsilon against RFC

252 ter Pol delta activity or position it on the lagging strand.

253 eceded by the migration of HmpF-GFPuv to the lagging cell poles.

254 tightly to Pol delta and recruits it to the lagging strand.

255 this signal requires no transmission to the lagging-strand polymerase through protein or DNA interac

256 trand is replicated continuously whereas the lagging strand is replicated in discrete segments known

257 These lags decline in species that have colonized more sites a

258 As climate change accelerates, these lags will likely increase, potentially threatening the p

259 We interpret these lags as indicating that Great Basin climate is sensitive

260 kening trend in springtime zonal winds, this lagged relationship can also explain an important fracti

261 nosa and Escherichia coli) over time through lag and log growth phases and following antibiotic admin

262 However, there is a time lag before changes in gene expression, which suggests th

263 sed on obesity trends, we established a time lag between obesity prevalence and NASH-related waitlist

264 current genetic diversity, suggesting a time lag in genetic responses.

265 ay significant limitations, including a time lag of weeks to months and low rates of therapeutic effi

266 vents, which was caused by the combined time lag effects of ENSO events on precipitation and temperat

267 An approximately 8-month time lag was detected between tropical wetland CH4 emissions

268 s significantly younger 'diet age', the time lag between carbon fixation by photosynthesis and its us

269 mics were encoded as edge weights using time lagged transfer entropy, a method for quantifying inform

270 ffusive behavior at very short and long time lags, as observed in several experiments.

271 urons was strong and extended over long time lags, whereas coupling among auditory cortex neurons was

272 mblies with arbitrary constellations of time lags, and at multiple temporal scales, partly due to the

273 lience mechanisms in quantitative terms-time lags, response speeds, and maximum magnitudes-and in lig

274 e center of the particle did not show a time-lag characteristic of slow-transport into the particle i

275 tion 95 million years ago, fit such a 'time-lag' model of post-WGD radiation, which occurred alongsi

276 e colonization with a recovery state or time-lag for disturbed ("focal") patches, thus assuming that

277 rs in the differential frames, when the time-lag is set to the one corresponding to the maximum dynam

278 We use a coupling measure based on time-lagged mutual information to identify effective connecti

279 Significant time-lagged correspondence was evident between nifH transcrip

280 portance of long-distance dispersal and time-lags on population establishment and spatial spread.

281 btained subtracting images at different time-lags.

282 ajor area of investigation that continues to lag is the connection between the effects of defensins i

283 ression fail for millions of patients due to lag in clinical response and non-adherence.

284 MLI activity tended to lag behind the onset of sustained licking episodes, indi

285 AN components at the centromere and leads to lagging chromosomes and spindle pole defects.

286 as the climate warms, potentially leading to lags in northward range shifts for some species.

287 d is stopped by a block on the non-tracking (lagging) strand.

288 phosphate-steering promotes an unanticipated lagging-strand template-switch mechanism during replicat

289 the relation between different time-updated lagged and cumulative exposures (CD4 cell count, CD8 cel

290 and independence from brain volume variation-lags far behind that for the cerebrum.

291 tion terms to test associations over varying lag lengths.

292 ADT exposure was lagged by 1 year to account for delays associated with t

293 s but not of interferon-gamma and TNF, which lagged behind the amelioration.

294 the impacts of heat waves on mortality with lag effects internationally.

295 This shift was followed, with lags of 1-3 years, by 3- to 19-fold increased abundances

296 but rates of breastfeeding among black women lag behind those in the general population.

297 tins as a time-varying covariate with 1-year lag.

298 d BMI categories in 2002, assuming a 10-year lag between exposure to diabetes or high BMI and inciden

299 CI, 1.77-5.37), and after applying a 3-year lag period (OR, 1.09 per procedure; 95% CI, 1.03-1.14 an

300 Fixed-effects models with a 1-year-lagged BMI were estimated.