ライフサイエンスコーパス: lagging chromosomes

1 yed in akir-1 mutants and are accompanied by lagging chromosomes.

2 ls overexpressing Mad2 display high rates of lagging chromosomes.

3 rora B through Chk1, preventing formation of lagging chromosomes.

4 micronuclei form when mitotic errors produce lagging chromosomes.

5 defects such as centrosome amplification and lagging chromosomes.

6 metaphase plate and an increase in anaphase lagging chromosomes.

7 indles and asymmetric, bipolar spindles with lagging chromosomes.

8 utations cause chromosome missegregation and lagging chromosomes.

9 ore defects within the regions of misaligned/lagging chromosomes.

10 n early mitosis, but few anaphase cells show lagging chromosomes.

11 events merotelic kinetochores from producing lagging chromosomes.

12 ather than just one and can produce anaphase lagging chromosomes, a major source of aneuploidy.

13 As micronuclei formed from lagging chromosomes also activate this pathway, recognit

14 he presence of supernumerary centrosomes and lagging chromosomes among mitotic NPCs.

15 luding premature chromatid separation (PCS), lagging chromosomes, anaphase bridges, micronuclei, cent

16 These disruptions contribute to lagging chromosomes and aberrant microtubule bridges dur

17 it from MII, there is a dramatic increase in lagging chromosomes and an inhibition of cytokinesis.

18 These cells often entered anaphase with lagging chromosomes and elicited increased segregation e

19 ore anaphase onset, but ZW10 mutants exhibit lagging chromosomes and irregular chromosome segregation

20 Real-time imaging of live NPCs revealed lagging chromosomes and multipolar divisions.

21 AN components at the centromere and leads to lagging chromosomes and spindle pole defects.

22 g the number of abnormal anaphase cells with lagging chromosomes and/or acentric fragments.

23 errors in chromosome segregation (including lagging chromosomes), and abnormalities in spindle morph

24 induces premature separation of chromatids, lagging chromosomes, and anaphase bridges.

25 in B by the APC/C, supernumerary centrioles, lagging chromosomes, and aneuploidy.

26 rotelic microtubule-kinetochore attachments, lagging chromosomes, and aneuploidy.

27 salignment, chromosomal congression defects, lagging chromosomes, and chromosome missegregation.

28 indle morphology, increased the frequency of lagging chromosomes, and inhibited the proliferation of

29 wn of the Twins B subunit led to bridged and lagging chromosomes, and knockdown of the B' Widerborst

30 late, premature sister chromatid separation, lagging chromosomes, and multipolar spindles.

31 tion and aberrant mitosis with misaligned or lagging chromosomes are significantly increased in Ptpn1

32 festing disorganized spindle, misaligned and lagging chromosomes as well as micronucleated cells.

33 ypes associated with zw10 and rod mutations: lagging chromosomes at anaphase and precocious sister ch

34 rmation of stable attachments and eventually lagging chromosomes at anaphase I.

35 ing division, these cells frequently exhibit lagging chromosomes at both metaphase and anaphase, sugg

36 1.16% of untreated anaphase cells exhibiting lagging chromosomes at the spindle equator, and this per

37 uploidy phenotype involved the occurrence of lagging chromosomes but not chromosome bridges, indicati

38 High levels of mBub3 remain associated with lagging chromosomes but not with correctly aligned chrom

39 splay a significantly increased frequency of lagging chromosomes during anaphase.

40 umerary centrosomes, multipolar spindles and lagging chromosomes during anaphase.

41 rebral cortical neuroblasts in situ detected lagging chromosomes during mitosis, suggesting the norma

42 ic checkpoint, and an increased frequency of lagging chromosomes during mitosis.

43 shown to cause centrosome amplification and lagging chromosomes during mitosis.

44 ing chromosomes in anaphase, suggesting that lagging chromosomes fail to segregate properly.

45 congression and an increased propensity for lagging chromosomes following mitotic delay.

46 Thus, lagging chromosomes in anaphase are symptomatic of defec

47 We discovered that the frequency of lagging chromosomes in anaphase is very sensitive to par

48 d during mitosis, we show that a majority of lagging chromosomes in anaphase segregate to the correct

49 The single kinetochores of lagging chromosomes in anaphase were stretched laterally

50 tly show alignment defects during metaphase, lagging chromosomes in anaphase, and chromatin bridges d

51 efects in chromosome alignment in metaphase, lagging chromosomes in anaphase, failure of cytokinesis

52 damage and consequent chromatin bridges and lagging chromosomes in anaphase, frequently leading to c

53 ith merotelic kinetochores often manifest as lagging chromosomes in anaphase, suggesting that lagging

54 tubule (k-MT) attachments, which manifest as lagging chromosomes in anaphase.

55 ected by the mitotic checkpoint, and induces lagging chromosomes in anaphase.

56 Kif2a-depleted animal caps have anaphase lagging chromosomes in stage 9 and 10 embryos and subseq

57 s allows the correction and reintegration of lagging chromosomes in the main nuclei before completion

58 bit mitotic defects including misaligned and lagging chromosomes, multipolar spindles, and increased

59 nd thereby, delays abscission in response to lagging chromosomes, nuclear pore defects, and tension f

60 However, it remains unknown whether the lagging chromosomes observed in anaphase segregate to th

61 show chromosome segregation defects such as lagging chromosomes on the spindle during anaphase and h

62 t mitoses, including misaligned chromosomes, lagging chromosomes, polylobed nuclei, and delayed passa

63 ly inactive Smurf2 results in misaligned and lagging chromosomes, premature anaphase onset, and defec

64 increase in anaphase-lagging cells, with the lagging chromosomes showing reduced centromere protein C

65 -MT attachments and leading to high rates of lagging chromosomes that missegregate.

66 uently enter anaphase in a timely manner but lagging chromosomes then manifest.

67 Extended anaphases, chromosome bridges, and lagging chromosomes were frequent during these polyploid

68 tly, these cells exhibit a high frequency of lagging chromosomes when they enter anaphase.

69 Intriguingly, the number of lagging chromosomes with high Bub3 staining increases dr

70 rized by chromosomal bridges in anaphase and lagging chromosomes, without affecting spindle checkpoin