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1 een the long-axis direction of two different lamellipodia).
2 activity and drives its localization within lamellipodia.
3 MRCKalpha colocalize at the cell membrane in lamellipodia.
4 y compressed axial cell length and collapsed lamellipodia.
5 location to and efficient incorporation into lamellipodia.
6 d is required for Rac1-mediated formation of lamellipodia.
7 cells, where it colocalizes with F-actin in lamellipodia.
8 number and disturbed orientation of cellular lamellipodia.
9 unction in live fibroblasts with established lamellipodia.
10 tion between cells is mediated by protruding lamellipodia.
11 ited elongated cellular tails and diminished lamellipodia.
12 axillin-based focal adhesion within the same lamellipodia.
13 leton in the apical cortex and in protruding lamellipodia.
14 play growth cones with significantly smaller lamellipodia.
15 protein accumulation at the leading edge of lamellipodia.
16 e line depleted of Arp2/3 complex that lacks lamellipodia.
17 of SMN and actin at the leading edge at the lamellipodia.
18 n inactive conformation and localizes to the lamellipodia.
19 elationship between VIF and the formation of lamellipodia.
20 timal protrusion speed for the actin mesh in lamellipodia.
21 h APCs, likely due to defective formation of lamellipodia.
22 nt to induce filopodia, together they induce lamellipodia.
23 dilator-stimulated phosphoprotein-containing lamellipodia.
24 nding to integrin-linked kinase (ILK) in the lamellipodia.
25 anized actin filament structures and induced lamellipodia.
26 modulates the balance between filopodia and lamellipodia.
27 ce of paxillin-containing focal adhesion and lamellipodia.
28 wth factor-stimulated membrane protrusion at lamellipodia.
29 ovarian cancer cells with PI3KC2beta-driven lamellipodia.
30 lting in FAK activation and the formation of lamellipodia.
31 logy of their tips, which lack filopodia and lamellipodia.
32 ells increased F-actin and Arp2/3 complex in lamellipodia.
33 s templates for formation and orientation of lamellipodia.
34 ated by the Arp2/3 complex, forming ruffling lamellipodia.
35 (Arp2/3) complex in the membrane ruffles and lamellipodia.
36 and filopodial spike-based protrusions, not lamellipodia.
37 es, which are essentially stand-alone motile lamellipodia.
38 luding protrusions ranging from filopodia to lamellipodia.
39 zed HGF-mediated effects on the formation of lamellipodia, a pre-requisite for migration using human
40 on two-dimensional (2D) surfaces by forming lamellipodia-actin-rich extensions at the leading edge o
41 rin-mediated adhesion and down-regulation of lamellipodia activity and a cytosolic pool that down-reg
42 sion complexes and that E-cadherin regulates lamellipodia activity and cell migration directionality,
45 KAI1/CD82, consistent with the diminution of lamellipodia and actin cortical network; while the growt
46 riphery and a decrease in the persistence of lamellipodia and cell motility, a phenotype consistent w
47 ion of SphK1/p-SphK1 with actin/cortactin in lamellipodia and down-regulation or inhibition of SphK1
48 lls along the edge of a wound still extended lamellipodia and elongated toward the wound but were inh
51 ct in parallel to control actin dynamics and lamellipodia and filopodia formation during axon guidanc
52 well as p21-activated kinase (PAK)-mediated lamellipodia and filopodia formation following bradykini
53 imulation, but does not affect PAK-meditated lamellipodia and filopodia formation following PDGF and
57 growth cone reads guidance cues and extends lamellipodia and filopodia, actin-based structures that
58 trated specifically at the tips of extending lamellipodia and filopodia, instead of endosomes as in o
59 , observed as cytoskeleton protrusions-i.e., lamellipodia and filopodia-were reduced after treatment.
63 from a dense meshwork of actin filaments in lamellipodia and from actin bundles in the filopodia.
64 ed, in neuronal cells alpha-COP localizes to lamellipodia and growth cones and moves within the axon,
67 romoted nascent FA formation and turnover in lamellipodia and inhibited the frequency and rate of FA
68 that did not diffuse rapidly enough to enter lamellipodia and instead stably bound adhesion complexes
70 Scar/WAVE complex is absolutely required for lamellipodia and is a key effector in cell migration, bu
72 rotein is abundantly expressed in microglial lamellipodia and maintains alkaline pHi in response to B
75 actin bundling facilitates the formation of lamellipodia and normal immunological synapses and there
77 f small, mobile M1-AQP4-enriched arrays into lamellipodia and preferential interaction of large, M23-
78 generated branched actin networks comprising lamellipodia and pseudopodia by virtue of its ability to
79 we triggered highly localized retraction of lamellipodia and redirection of polarization and migrati
81 , which is essential for AbpG to localize to lamellipodia and to rescue the phenotype of abpG(-) cell
82 ed geometries exhibit polarized extension of lamellipodia and upon release, migrate preferentially al
83 cells trigger cycles of retraction of local lamellipodia and, concomitantly, strengthen local adhesi
85 The activity of Rac, formation of stable lamellipodia, and directed migration are restored in bet
86 l elongation and cell body rounding, loss of lamellipodia, and formation of thick membrane extensions
87 morphology, the development of filopodia and lamellipodia, and phagocytosis of WNV-infected cells and
89 EGF led to cell polarization in the form of lamellipodia, and this occurred through a mechanism invo
90 osolic alphaE-catenin to mitochondria alters lamellipodia architecture and increases membrane dynamic
93 r order structures such as stress fibers and lamellipodia are fundamental for cell migration and adhe
97 o shallow gradients of PDGF, indicating that lamellipodia are not required for fibroblast chemotaxis.
102 unction formation in endothelial cells using lamellipodia as the initial protrusive contact, subseque
103 to larger cell size and remarkably developed lamellipodia as well as accumulation of filamentous acti
104 equirements of transitions between blebs and lamellipodia, as well as the time scales on which they o
105 he Scar/WAVE regulatory complex (WRC) drives lamellipodia assembly via the Arp2/3 complex, whereas th
106 vestigated the possible role of INF2 in both lamellipodia-associated actin dynamics and actin-depende
108 thesis that the principal role of cofilin in lamellipodia at steady state is to break down F-actin, c
109 a stationary cell, the cell polarizes, forms lamellipodia at the leading edge (LE), and triggers the
110 ep during cell migration is the formation of lamellipodia at the leading edge of migrating cells.
113 y, tumor cells overexpressing Dyn2 protruded lamellipodia at twice the rate, migrated faster (180%) a
117 ablished that nonlinear elasticity supported lamellipodia-based migration, whereas linear elasticity
119 by implicating CP in filopodia as well as in lamellipodia, both of which are important for locomotion
120 the distal margin of membrane protrusions or lamellipodia but a mutant NHE1-KRA2 lacking binding site
121 ARPC3(-/-) fibroblasts were unable to extend lamellipodia but generated dynamic leading edges compose
122 bolished the BK-triggered dynamic changes of lamellipodia, but also reduced microglial motility and m
123 etwork density and protrusion persistence of lamellipodia by controlling the state of actin-driven pr
125 embrane protrusions, such as multiple blebs, lamellipodia, combinations of both, or absence of any su
126 animal cells initiate crawling by protruding lamellipodia, consisting of a dense network of actin fil
127 hermore, rapid transitions between blebs and lamellipodia could also be triggered upon changes in sub
129 cells, showing the cytoskeleton dynamics in lamellipodia during protrusion and mitochondria displace
130 ortant in vivo as well, for the formation of lamellipodia during the ventral enclosure event of Caeno
131 cell types, coronins exert their effects on lamellipodia dynamics by an inhibitory interaction with
132 Capping protein in regulating filopodia and lamellipodia dynamics in Drosophila melanogaster cells a
133 f polarity, as evidenced by the formation of lamellipodia encircling the entire cell, as well as redu
135 s into the Arp2/3 complex's critical role in lamellipodia extension and directional fibroblast migrat
136 inant-negative (DN) tail-tip expression lack lamellipodia, fail to migrate into the wound, and form s
137 f actin filament-based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs
139 ed colonic epithelial cells showed defective lamellipodia, focal adhesions, and repair after wounding
140 followed by relocalization to the actin-rich lamellipodia for dynamic forward protrusion of the cells
141 he observed dynamic: (1) competition between lamellipodia for shared pools of Rac and Rho, (2) activa
144 dependent effect, coupled with filopodia and lamellipodia formation and an enrichment of a pool of th
145 tive mutant of ARF6 attenuates inhibition of lamellipodia formation and cell migration by PITs, confi
147 nsulin-like growth factor (IGF-1)-stimulated lamellipodia formation and cell motility, indicating inv
149 ine triphosphate synthesis inhibitor reduced lamellipodia formation and decreased breast cancer cell
150 t, PI3k, and Akt phosphorylation, suppressed lamellipodia formation and endothelial cell migration.
152 as aberrant and associated with dysregulated lamellipodia formation and impaired persistence of migra
154 with thrombin) inhibited focal adhesions and lamellipodia formation and led to impaired cell migratio
155 Exo70 on the Arp2/3 complex is required for lamellipodia formation and maintaining directional persi
156 30(Cas)-deficient murine fibroblasts induced lamellipodia formation and membrane ruffling, which was
159 uing turning behavior of T cells mediated by lamellipodia formation and MLCK activity may be importan
160 have previously reported that HGF stimulates lamellipodia formation and motility of human lung microv
161 kt signaling and NADPH oxidase activation in lamellipodia formation and motility of lung endothelial
162 MEK inhibition was sufficient to promote lamellipodia formation and oppose filopodial actin-spike
163 omolog 2 (Spns2), and S1P receptor, S1P1, in lamellipodia formation and perhaps motility of HLMVECs.
164 MYH9(E1841K/E1841K) mice exhibited increased lamellipodia formation and reorganization of F-actin str
165 ibit growth factor-induced actin remodeling, lamellipodia formation and, ultimately, cell migration a
167 d with actin cytoskeleton reorganization and lamellipodia formation in FLS from rats and RA patients.
172 factor for the recruitment of modulators of lamellipodia formation such as capping protein or cofili
173 he increase in endocytosis and the defect in lamellipodia formation were associated with reduced chem
174 and decreased the frequency of RAC1-positive lamellipodia formation while CERS6 overexpression promot
175 enriched at the cell periphery to facilitate lamellipodia formation while Rho kinase exhibited a sign
177 ing Drp1 or overexpression of Mfn1 inhibited lamellipodia formation, a key step for cancer metastasis
178 ne receptor 4, RGS4 disrupted Rac1-dependent lamellipodia formation, a key step involved in cancer mi
179 e precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation.
180 n dynamics associated with barrier function, lamellipodia formation, and cell migration via modulatio
182 mbrane, as well as promoting cell spreading, lamellipodia formation, and membrane ruffling, cell morp
183 hese results suggest that HGF/c-Met-mediated lamellipodia formation, and perhaps motility is dependen
184 S precursor migration, cell polarization and lamellipodia formation, and that vitamin A depletion cau
185 proteins resulted in more cell spreading and lamellipodia formation, causing accumulation of more mit
186 Drosophila macrophages results in defects in lamellipodia formation, cell spreading, and redistributi
187 Crk-associated substrate (p130Cas)-mediated lamellipodia formation, countering the invasive phenotyp
188 o reduced ENS precursor migration as well as lamellipodia formation, proliferation, and survival in c
189 is and NADPH oxidase attenuated HGF- induced lamellipodia formation, ROS generation and cell migratio
190 ulation of Spns2 also suppressed HGF-induced lamellipodia formation, suggesting a key role for inside
191 tion in 3D collagen, but was dispensable for lamellipodia formation, suggesting that vinculin-mediate
192 ssion of wild type Nanog increased filopodia/lamellipodia formation, whereas mutant Y35F and Y174F Na
204 dothelia and epithelia suggests that ventral lamellipodia formed as a response to force imbalance and
205 ide and cyclodextrin on the force exerted by lamellipodia from developing growth cones (GCs) of isola
206 ACF), is similar to retrograde actin flow in lamellipodia, growth cones, immunological synapses, dend
208 t STRADalpha depletion results in misaligned lamellipodia, improper Golgi positioning, and reduced in
209 focal adhesions (FAs) assemble in protruding lamellipodia in association with rapid filamentous actin
211 ng, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a centra
218 in generated several profound effects on the lamellipodia, including an increase of F-actin, a rearwa
219 udies have suggested that structures besides lamellipodia, including lamella and filopodia, may have
222 at their tips, the protrusion efficiency of lamellipodia is determined by a finely tuned balance bet
223 s, suggesting that one principle function of lamellipodia is to organize cell-matrix adhesions in a s
227 During development, Schwann cells extend lamellipodia-like processes to segregate large- and smal
230 malian cells lacking CARMIL1 have defects in lamellipodia, macropinocytosis, cell migration, and Rac1
231 about the architecture and dynamics of thin lamellipodia made by slow-moving cells on flat surfaces,
232 partial retraction of the nearby protruding lamellipodia membrane and a strengthening of paxillin-ba
233 ions of actin-rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the c
234 ho-Elmo and ITSN1 co-localize with GPR124 at lamellipodia of adhering endothelial cells, where GPR124
236 FM force-distance (f-d) curves obtained from lamellipodia of live cells often exhibit a signal from w
237 localized with cytoskeletal protein ezrin in lamellipodia of microglia and maintained its more alkali
238 riven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant f
251 ng diverse actin-based structures, including lamellipodia, podosomes, and endocytic actin networks.
253 loration, with F-actin bundles directing and lamellipodia propagating the process and with signaling
255 increase in plasma membrane tension stopped lamellipodia protrusion and activated an exocytotic burs
258 s study, we show that during cell spreading, lamellipodia protrusion flattens plasma membrane folds a
263 rganization to form cell surface extensions (lamellipodia) required for cell migration/invasion durin
265 by confined Ca(2+) pulses that promote local lamellipodia retraction and adhesion cycles along the le
268 t and fusing myoblasts, as well as triggered lamellipodia, spreading, and fusion of myoblasts through
270 numerous endocytic cups instead of the broad lamellipodia structure characteristic of moving cells.
273 s, endothelial cells generate unique ventral lamellipodia that propagate via integrins toward and acr
274 the ECM enforces spatial constraints on the lamellipodia that result in cell shape elongation and en
275 ing the motion of the layer are the force of lamellipodia, the adhesion of cells to the substrate, an
276 interaction is essential for the assembly of lamellipodia, the formation of ruffles, and the process
277 ular fibronectin formed increased numbers of lamellipodia; their random motility and chemotaxis also
278 itochondria actively infiltrate leading edge lamellipodia, thereby increasing local mitochondrial mas
279 ac1 activation around the periphery in broad lamellipodia, thereby inhibiting directed migration and
280 ated protein 2/3 complex (ARP2/3)-controlled lamellipodia to appear intermittently at those sites.
281 bilization, and timely turnover of NA within lamellipodia to couple actin-driven protrusion to adhesi
283 t protrusions, from keratocytes dominated by lamellipodia, to growth cones combining filopodia and la
287 lysis revealed that G-actin concentration in lamellipodia was comparable to that in the cell body.
288 phorylation of SphK1 and its localization in lamellipodia was dependent on c-Met and ERK1/2 signaling
289 that can be induced to form either blebs or lamellipodia, we systematically assessed the mechanical
291 ntoured than static tips but no filopodia or lamellipodia were observed, even in db-cAMP; and 5) duri
292 in increases the number of ARP2/3-controlled lamellipodia, whereas overexpression of wild-type VE-cad
293 CK2-mediated suppression of Rac1 activity in lamellipodia, whereas RhoC promotes polarized migration
294 bstratum, eukaryotic cells project sheetlike lamellipodia which contain a dynamically remodeling thre
295 ls spontaneously formed protrusions, such as lamellipodia, which are required for generating locomoti
297 olarity by increasing myosin accumulation in lamellipodia, which locally decreases protrusion lifetim
299 ratinocytes lack polarity, assemble multiple lamellipodia with a 2x increased area over controls, dis
300 gion, formation of cortical actin-rich large lamellipodia with an upregulation of cortactin, and decr
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