ライフサイエンスコーパス: laminarin

1 lucanase activity on the beta-1,3-1,6-glucan laminarin.

2 ilar activities compared to those of natural laminarin.

3 gy adapted to efficient degradation of algal laminarin.

4 ibited by the soluble beta-glucan antagonist laminarin.

5 ntage was further reduced in the presence of laminarin.

6 on of Syk and this response was inhibited by laminarin.

7 Laminarin (0.1%) enhances expression after 18 h and othe

8 ere cultured with soluble chitin, mannan, or laminarin (a polymer of beta-glucan), 1 to 10 microm bet

9 lucose homopolymer] but was not inhibited by laminarin [a beta(1-->3)-linked glucose homopolymer].

10 The carboxyl-terminal domain bound to laminarin, a beta-1,3-glucan with beta-1,6 branches, but

11 Laminarin, a beta-1,3-glucan, presented two classes of b

12 Laminarin, a beta-glucan ligand of Dectin-1, was incorpo

13 However, addition of laminarin, a glucose polysaccharide (~6 kDa) containing

14 rom Manduca sexta betaGRP2 (N-betaGRP2) with laminarin, a soluble form of beta-1,3-glucan.

15 lucan-recognition protein in the presence of laminarin, a soluble glucan, stimulated activation of pr

16 e beta-1,3-glucan curdlan but not on soluble laminarin; additional deletion of the CBM6 also did not

17 ation of prophenoloxidase in plasma, whereas laminarin alone did not.

18 Vaccine containing laminarin also affected distribution of IgG subclasses,

19 An increased level of beta-1,6 branching in laminarin also results in destabilization of the macro c

20 an receptor antagonists laminariheptaose and laminarin also substantially reduce the ability of the P

21 cated that all of the preparations contained laminarin although their molecular mass varied considera

22 Blocking experiments with laminarin and mannan supported the conclusion that diffe

23 f two fluorescently labeled polysaccharides, laminarin and xylan, in environmental samples.

24 C. neoformans-selected B-1 B cells secreted laminarin- and C. neoformans-binding IgM.

25 In this study, laminarin (beta-1,3-glucan) but not sialic acid, mannan

26 Laminarin (beta-glucan) or galactose-BSA were not inhibi

27 Our data demonstrate that laminarin can be either a Dectin-1 antagonist or agonist

28 This enzyme did not hydrolyze laminarin, carboxymethylcellulose, pustulan, or xylan.

29 ctly adapted to the U-shaped conformation of laminarin chains in solution and thus explains the predo

30 ucan), 1 to 10 microm beta-glucan particles, laminarin-coated latex beads, 1 microm latex beads, 50 t

31 ence interval [CI], 3.0 to 11 microM), while laminarin competed for 69% +/- 6% of binding sites, with

32 us derived from this study for the N-betaGRP-laminarin complex in solution differs from the one in wh

33 (AUC) studies of formation of the N-betaGRP-laminarin complex show that ligand binding induces self-

34 Two of the laminarins contained substantial quantities of very low

35 nal deletion of the CBM6 also did not affect laminarin degradation but further decreased curdlan hydr

36 FRET spectra of the triple-helix glucan, laminarin, doubly labeled with 1-aminopyrene as donor pr

37 The soluble complex with laminarin formed in the plasma also stimulated pro-PO ac

38 d to directly bind to live mycobacteria in a laminarin-inhibitable manner indicating the presence of

39 Soluble mannan, but not soluble laminarin, inhibited cytokine production following stimu

40 Laminarin is a (1-->3, 1-->6)-beta-glucan that is widely

41 antagonist, however, there are reports that laminarin is also a Dectin-1 agonist.

42 te in part to the stability of the N-betaGRP-laminarin macro complex and that a decreased stability i

43 These laminarins may be useful in elucidating the structure an

44 y low m.w. compounds, some of which were not laminarin. moieties could be significantly reduced by ex

45 ure, likely containing six protein and three laminarin molecules (~102 kDa).

46 ype, while the defence program after chitin, laminarin, oligogalacturonide or flg22 treatment and the

47 proposed to bind to a triple-helical form of laminarin on the basis of an X-ray crystallographic stru

48 Treatment of SpDC with laminarin or glucan phosphate, two molecules known to bl

49 ited by glycogen, dextran, mannan, pustulan, laminarin, or a low molecular weight beta-(1-3)-glucan,

50 and in cells exposed to lipopolysaccharide, laminarin, or viral immune challenge.

51 cal properties, purity, and structure of the laminarin preparation employed.

52 g, and biological activity of five different laminarin preparations from three different commercial s

53 All of the laminarin preparations were bound by recombinant human D

54 igands for the receptor in the bacterium and laminarin pretreatment resulted in reduced association o

55 Strain 83-1 furthermore hydrolysed laminarin, pullulan and xylan, and corresponding polysac

56 ed glucosyl homopolysaccharide (pustulan and laminarin, respectively), suggesting that SP-D recognize

57 Additionally, pustulan but not laminarin strongly inhibited SP-D binding to A. fumigatu

58 We were able to identify a laminarin that is a Dectin-1 agonist and a laminarin tha

59 a laminarin that is a Dectin-1 agonist and a laminarin that is Dectin-1 antagonist, both of which are

60 m organisms that are in contact with genuine laminarin, the storage polysaccharide of brown algae.

61 Laminarin treatment also inhibited mycobacterial-induced

62 The remaining laminarin was a Dectin-1 antagonist, but when the low m.

63 etyl-D-glucosamine, mannose-6-phosphate, and laminarin were found to inhibit adhesion of T84 cells to

64 In both human and mouse cells, two laminarins were Dectin-1 antagonists and two were Dectin

65 , BhCBM56, bound the soluble beta-1,3-glucan laminarin with a dissociation constant (Kd ) of approxim