ライフサイエンスコーパス: laminin

1 ue sections were stained for C5b-9, C4d, and laminin.

2 collagen III, collagen IV, fibronectin, and laminin.

3 could be modulated by the adhesion molecule laminin.

4 ith fibronectin but not on those coated with laminin.

5 ins, such as fibronectin (FN), collagen, and laminin.

6 and IV, as well as elastin, fibronectin, and laminin.

7 on of alpha7beta1 integrin, which also binds laminin.

8 atrix containing fibronectin, fibrillin2 and laminin.

9 a4-integrin along with its matrix substrate, laminin.

10 issue-restricted isoforms of collagen IV and laminin.

11 hologs (Paf, AfeA, and MntC) interacted with laminin.

12 d when mAgrin is in molar excess relative to laminin.

13 GC axons on substrates of Nogo-A-Fc, but not laminin.

14 ronectin levels with little direct effect on laminin.

15 proteins, including perlecan, collagens, and laminins.

16 demonstrating increases in ECM collagens and laminins.

17 eta2 chain, demonstrating that they may bind laminins.

18 Previous studies demonstrated that laminin 1 (L1) is critical for intact salivary cell clus

19 The processes differentially contribute on laminin-1 and fibronectin due to selective actin tetheri

20 On laminin-1, NGF induced greater vinculin-dependent adhesi

21 hat is unclear from these studies is whether laminin-111 can restore failed regeneration to laminin-a

22 Here we report a biologically-active laminin-111 fragment generated by matrix metalloproteina

23 tein therapy to improve muscle regeneration, laminin-111 or phosphate-buffered saline-treated laminin

24 To investigate the potential of laminin-111 protein therapy to improve muscle regenerati

25 which in turn led to increased secretion of laminin-111.

26 dy2J mice) express a nonpolymerizing form of laminin-211 (Lm211) and are a model for ambulatory-type

27 ression of the laminin alpha2 subunit of the laminin-211 heterotrimer expressed by astrocytes and per

28 Our work suggests a model in which Laminin-211 mediates GPR126-induced cAMP levels to contr

29 1 confirmed binding to purified laminin-421, laminin-211, and laminin-alpha4.

30 of GPR126 are governed by interactions with Laminin-211, which we define as a novel ligand for GPR12

31 e autoantibodies against the alpha3 chain of laminin 332 (LAMalpha3), a structural protein of epiderm

32 n depends on alpha3beta1 integrin binding to laminin 332 (LN332; also known as laminin 5), whereas an

33 or receptor in the epidermis for adhesion to laminin-332 (LN-332), has critical roles in basement mem

34 Eleven as yet unreported mutations in the laminin-332 genes were detected.

35 The diagnosis was based on the absence of laminin-332 in skin biopsies.

36 osed epidermolysis bullosa acquisita or anti-laminin-332 mucous membrane pemphigoid.

37 , a major receptor for epidermal adhesion to laminin-332, is critical for proper basement membrane or

38 Graft cells, but no laminin-332, were detected in skin biopsies.

39 Laminin-421 and -211 were identified by proximity-based

40 erve sheath, particularly perineurium, where laminin-421 is predominant.

41 xpressing NP41 confirmed binding to purified laminin-421, laminin-211, and laminin-alpha4.

42 TAT3-dependent manner, which also stabilizes laminin 5 and engages cells to form hemidesmosome-like j

43 in), basement membrane assembly (Collagen 7, Laminin 5), differentiation (K13, K3), proliferation (Ki

44 binding to laminin 332 (LN332; also known as laminin 5), whereas antibodies that block alpha6beta4 bi

45 of apical-basal cell polarity, as well as in laminin-511 and basement membrane assembly at the tip of

46 We found that recombinant laminin-511 E8 fragments are useful matrices for maintai

47 l microfabricated slides (from CYTOO), human laminin-521 (LN-521) as extracellular matrix coating, an

48 Glial cells in many organisms secrete laminin, a large heterotrimeric protein consisting of an

49 Laminin, a major component of the basement membrane, pla

50 urther, we demonstrate that the BM component laminin accumulates at the BM gap edge and promotes incr

51 These data suggest that laminins act as links among pre- and post-synaptic lamin

52 Thus Met promotes survival of laminin-adherent cells by maintaining integrin alpha3bet

53 In addition, we show that laminin alone is able to partially reverse the muscle dy

54 its extracellular matrix interaction partner laminin alpha 4 (LAMA4) emerged as the most consistently

55 flexible hinge region between the fifth LNS (laminin-alpha, neurexin, sex hormone-binding globulin) d

56 n I, fibronectin, smooth muscle alpha-actin, laminin alpha1, and hyaluronan and proteoglycan link pro

57 Laminin alpha1, beta1 and gamma1, abundantly released by

58 nidogen-2 in their pericellular matrix, and laminin-alpha1 enhanced collagen type II and reduced col

59 genitor cells (CPCs) produced high levels of laminin-alpha1, laminin-alpha5, and nidogen-2 in their p

60 troglycan (alphaDG) and the up-regulation of laminin alpha2 and dystrophin surrogates known to inhibi

61 Complete loss of the laminin alpha2 chain in mice results in a severe muscula

62 The adhesion molecule laminin alpha2 chain interacts with the dystrophin-glyco

63 trophin-glycoprotein complex further protect laminin alpha2 chain-deficient skeletal muscle fibers fr

64 genetic model have shown that a deletion of laminin alpha2 impedes male fertility by disrupting ecto

65 Of more importance, a knockdown of laminin alpha2 in Sertoli cells was shown to induce the

66 rrier by a local axis in the testis: role of laminin alpha2 in the basement membrane.

67 In short, laminin alpha2 in the BM seems to play a crucial role in

68 Here, we show that laminin alpha2 in the BM serves as the crucial regulator

69 Laminin alpha2 is one of the constituent components of t

70 Furthermore, laminin alpha2 knockdown also perturbed microtubule (MT)

71 t Lama2(-/-) mice, lacking expression of the laminin alpha2 subunit of the laminin-211 heterotrimer e

72 an or increased expression of dystrophin and laminin alpha2 surrogates in mature skeletal myofibers,

73 creases the overexpression of dystrophin and laminin alpha2 surrogates known to inhibit disease.

74 strophy type MDC1A is caused by mutations in laminin alpha2 that either reduce its expression or impa

75 histochemical analysis found deficiencies of laminin alpha2, alpha-dystroglycan, or collagen VI in 50

76 f matrix constituents (decorin, collagen VI, laminin alpha2, endostatin, endorepellin, and kringle V)

77 ves as the crucial regulator in this axis as laminin alpha2, likely its 80-kDa fragment from the C te

78 Mutations in laminin alpha2-subunit (Lmalpha2, encoded by LAMA2) are

79 integrin, Ptrh2 expression was decreased in laminin-alpha2 dyW null gastrocnemius muscle.

80 n shown to ameliorate disease pathology in a laminin-alpha2 knockout mouse model of muscular dystroph

81 nin-111 or phosphate-buffered saline-treated laminin-alpha2-deficient muscle was damaged with cardiot

82 minin-111 can restore failed regeneration to laminin-alpha2-deficient muscle.

83 Neuregulin 1 type III (Nrg1III) and laminin alpha2beta1gamma1 (Lm211) are the key axonal and

84 It has been shown that laminin alpha4 (endothelial laminin) regulates vascular

85 LNs, compared with immune LNs, and blocking laminin alpha4 function or inducing laminin alpha5 overe

86 The ratio of laminin alpha4 to laminin alpha5 was greater in domains

87 lycoprotein receptor capture also identified laminin-alpha4 and -gamma1.

88 ng to purified laminin-421, laminin-211, and laminin-alpha4.

89 blocking laminin alpha4 function or inducing laminin alpha5 overexpression disrupted T cell and DC lo

90 The ratio of laminin alpha4 to laminin alpha5 was greater in domains within tolerant LN

91 In isolated islets, laminin-alpha5 (found in both layers of the duplex BM) a

92 Collagen IV, pan-laminin, perlecan and laminin-alpha5 in the islet BM were significantly digest

93 PCs) produced high levels of laminin-alpha1, laminin-alpha5, and nidogen-2 in their pericellular matr

94 ations in human LAMB2 cluster in or near the laminin amino-terminal (LN) domain, a domain required fo

95 Laminin, an approximately 800-kDa heterotrimeric protein

96 important virulence factor interacting with laminin, an extracellular matrix protein ubiquitously ex

97 f oligodendrocytes from NSPCs was reduced on laminin, an outcome likely mediated by the alpha6 lamini

98 GN1 deletion causes an aberrant VE-cadherin, laminin and alpha6 integrin distribution in vessels, alo

99 ation (Ki-67), decreased neovascularization (laminin and alphaSMA), in addition to inflammation and a

100 collagen and alpha2-type IV collagen, gamma1-laminin and beta2-laminin, were significantly increased

101 ty to bind the extracellular matrix proteins laminin and cellular fibronectin.

102 In diabetic mice, Sema3a(+) exacerbates laminin and collagen IV accumulation in Kimmelstiel-Wils

103 as well as the extracellular matrix proteins laminin and collagen V.

104 The MV cargo proteins laminin and fibronectin interact with integrins along th

105 Similarly, disorganized laminin and fibronectin surround MZtmem2 cardiomyocytes,

106 filopodia and growth cone F-actin content on laminin and L1.

107 Lower levels of laminin and neurogenic locus notch homolog protein 1 but

108 two independent polymeric networks - one of laminin and one of type IV collagen (Figure 1, bottom).

109 PoT) printing technique enables fibronectin, laminin and other proteins to be applied to biomaterial

110 Among those, specific laminins and dystroglycan complexes contribute to Na(+)

111 Our novel findings that laminins and nidogen-2 drive CPCs toward chondrogenesis

112 of this study was to investigate the role of laminins and nidogen-2 in osteoarthritis (OA) and their

113 ize the vitreoretinal junction (fibronectin, laminin) and vitreous gel (opticin) markers.

114 M-2, junctional adhesion molecule-B (JAM-B), laminin, and cellular fibronectin, supported binding of

115 s of four matrix proteins-collagen I and IV, laminin, and fibronectin-in skin biopsies of patients wi

116 ure and composition in terms of collagen IV, laminin, and fibronectin.

117 ) proteins, including fibronectin, entactin, laminin, and insoluble elastin, as potently as matrix me

118 PrP(C), laminin, and metabotropic glutamate receptor 5 (mGluR5)

119 y to adhere to VK2 cells, to fibronectin and laminin, and to fibronectin-coated ME-180 cervical epith

120 with increases in collagen IV, decreases in laminin, and varied changes in fibronectin.

121 We demonstrate that subunits of laminins appear in OA cartilage and that nidogen-2-null

122 Laminin appeared to be a critical component in regulatin

123 hat neural stem cell biological responses to laminin are dependent on topographical context.

124 Laminins are constituents of the extracellular matrix an

125 Laminins are differentially expressed upon immunity or t

126 Laminins are extracellular matrix proteins, widely expre

127 Laminins are major constituents of the gliovascular basa

128 We hypothesize that laminins are required for proper trans-synaptic alignmen

129 Laminins are trimeric proteins that are major components

130 g of host cells and purified fibronectin and laminin, as well as Yop delivery, three mutations, F80A

131 a model of melanoma in vitro tumorigenesis, laminin-associated networks developed in association wit

132 rowth factor receptor alpha (PDGFRalpha) and laminin beta 1 (LAMB1) expression.

133 fied a rare single nucleotide variant in the laminin beta 4 gene (LAMB4) that segregated with disease

134 dation of extracellular matrix nidogen-1 and laminin beta1 in tumor xenografts.

135 ane biofunctionalized with a fragment of the laminin beta1-chain to modulate the expression of MMP2 i

136 nd neurologic defects caused by mutations in laminin beta2 (LAMB2), a major component of the glomerul

137 glycan can be co-immunoprecipitated with the laminin beta2 chain, demonstrating that they may bind la

138 In the absence of the laminin beta2 chain, the expression of many pre-synaptic

139 Mice with a targeted deletion of the laminin beta2 gene (Lamb2) exhibit retinal disruptions:

140 ing from defects in GBM structural proteins (laminin beta2 or collagen alpha3 IV), the GBM is irregul

141 of human nephrotic syndrome caused by mutant laminin beta2 protein-induced podocyte ER stress and AKI

142 mma localization of utrophin, restoration of laminin binding and amelioration of disease in the mdx m

143 We demonstrate in vitro that mAgrin enhances laminin binding to primary myoblasts and fibroblasts fro

144 uced a decrease of alphaDG glycosylation and laminin binding, even in WT animals.

145 we found that association of sarcospan into laminin-binding complexes is dependent on utrophin and a

146 The laminin-binding integrin alpha3beta1 is highly expressed

147 in, an outcome likely mediated by the alpha6 laminin-binding integrin, whereas similar effects were n

148 nd also appeared to bind collagen type V and laminin, but not other proteins, such as transferrin, he

149 RNAi, we further demonstrate that astrocytic laminin, by binding to integrin alpha2 receptor, prevent

150 utations in the extracellular matrix protein laminin cause severe consequences in glial wrapping and

151 a cells expressed increased alpha4 and beta1 laminin chains and alpha4 laminin expression was confirm

152 y biologically active peptides released from laminin chains.

153 composed of collagen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin + heparan sulfate

154 d (dcEF) when cultured on a poly-L-ornithine/laminin coated surface, while the fetal-derived neural p

155 On laminin-coated tracks (3-10 mum), these cells used an ef

156 mentin) and extracellular matrix components (laminin, collagen IV) correlate with tissue softening.

157 Laminins colocalized with NP41 within nerve sheath, part

158 20 was potentiated on rigid matrices at high laminin concentration.

159 acellular matrix (ECM) composed of collagen, laminin, Dally and Dally-like (Dlp) proteins that are st

160 over PCP mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cy

161 of active MMPs, facilitating fibronectin and laminin degradation, and likely contributing to the vari

162 ivating priming injuries, stimulated robust, laminin-dependent sensory axon regrowth past scar-formin

163 urther structures of FXI in complex with the laminin-derived peptide EFPDFP and a DFP peptide from th

164 Our results indicate a novel role for laminin-dystroglycan interactions in the cooperative int

165 With the use of laminin-enriched extracellular matrix (lrECM), we were a

166 g the globular domains, and also attached to laminin expressed on respiratory epithelial cells.

167 e used a reverse genetic approach to disrupt laminin expression in the vascular basement membrane and

168 pread small vacuole formation, and increased laminin expression underneath lens capsules suggest impa

169 d alpha4 and beta1 laminin chains and alpha4 laminin expression was confirmed by in situ hybridizatio

170 ctive oxygen species generation, and, matrix laminin expression.

171 ular matrix proteins, including those of the laminin family, formed regions within the LN that were p

172 Influence of BL proteins-laminin, fibronectin, collagen type IV, agrin, and perle

173 itary neuropathies associated with decreased laminin function are characterized by focally thick and

174 red primary human glioblastoma (GBM) TICs on laminin-functionalized ECMs spanning a range of stiffnes

175 Using a laminin-functionalized hydrogel system designed to mimic

176 st signal, controlled by cadherin, EGF-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2, C

177 ain (Val243-Ser635; chimera III) or the SHBG laminin G-type 1 subunit (Ser283-Val459; chimera I), res

178 ti-CASPR2 antibodies in the CSF targeted the laminin G1 and discoidin domains of CASPR2 in all patien

179 in these patients targeted the discoidin and laminin G1 domains of CASPR2 and always included IgG4 au

180 We demonstrate that loss of the laminin gamma subunit (LanB2) in the peripheral glia of

181 echanistic target of rapamycin complex 1 and laminin gamma1 accumulation in an AMP-activated protein

182 s (BMs) through high-affinity binding to the laminin gamma1 chain.

183 Autoantibodies against recombinant laminin gamma1 were detected by immunoblot in 8 of 12 pa

184 Autoantibodies against laminin gamma1 were determined by immunoblot.

185 alafil effect on high glucose stimulation of laminin gamma1.

186 global protein synthesis and matrix protein laminin gamma1.

187 ed P value < 10(-7)) and minor enrichment of laminin-gamma1 and collagens I and VI.

188 Proteolytic processing of the laminin-gamma2 chain is a hallmark of basement membrane

189 r alpha3beta1 in promoting the processing of laminin-gamma2 in cultured keratinocytes in vitro and in

190 membrane assembly/maturation through reduced laminin-gamma2 processing via mTLD/BMP-1.

191 critical regulator of alpha3beta1-dependent laminin-gamma2 processing, thereby expanding the role of

192 al density is significantly increased in the laminin gamma3-null (Lamc3(-/-)) retinal superficial vas

193 based on a stretch of 50 amino acids within laminin-gamma3 domain IV, could reversibly induce the im

194 pithelial cells cultured within collagen and laminin gels proliferate to form hollow and polarized sp

195 ith glycan structures functional for binding laminin globular domain-containing proteins.

196 While laminins have a critical structural role, recent evidenc

197 This basement membrane is rich in laminin-III (L1), which plays a critical role in salivar

198 Laminin immunostaining and quantitation of tissue extrac

199 Also, they bound laminin in a glucocorticoid-dependent manner.

200 l migratory and morphological reactions with laminin in different topographical contexts.

201 ble knockout (DKO) mice display disorganized laminin in meningeal fibroblasts and a cobblestone lisse

202 These data support a critical role of laminin in the regulation of PDGFRbeta(+) cell stemness,

203 investigate the function of pericyte-derived laminin in vascular integrity.

204 Finally, the role of the laminins in autoimmune diseases and transplantation will

205 od-brain barrier (BBB); however, the role of laminins in BBB development remains unclear.

206 The retina expresses several laminins in the outer plexiform layer (OPL), where they

207 oteins bound at the heparin-binding sites of laminin, including the globular domains, and also attach

208 lls to fibronectin, but not poly-d-lysine or laminin, induced YAP nuclear accumulation via the FAK-Sr

209 ne, we report that PDGFRbeta(+) cell-derived laminin inhibits their proliferation and adipogenesis, b

210 glycosylation of alpha-dystroglycan disrupts laminin interaction with alpha-dystroglycan and the extr

211 Enzymatic cleavage of intraretinal laminin is a biologically plausible mechanism for acute

212 Laminin is also found throughout multiple retinal layers

213 er, these data suggest that pericyte-derived laminin is involved in the maintenance of BBB integrity

214 The unique architecture of laminin is not currently amenable to determination at hi

215 evels at the sarcolemma, where attachment to laminin is restored.

216 Laminin is thus a highly important target for PF ortholo

217 Sixteen laminin isoforms have been described, each with distinct

218 d pericytes synthesize and deposit different laminin isoforms into the basement membrane.

219 ant P4 displayed a high binding affinity for laminin (Kd = 9.26 nM) and fibronectin (Kd = 10.19 nM),

220 store function of a polymerization-defective laminin, leading to normalized muscle structure and stre

221 mouse line, we report that loss of pericytic laminin leads to hydrocephalus and BBB breakdown in a sm

222 Netrin-1, a chemorepulsant, laminin-like matrix protein, promotes inflammation by pr

223 We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and t

224 The laminin (LM)-binding integrin alpha3beta1 is crucial for

225 Laminin LN domain mutations linked to several of the Lma

226 ch as Evans blue (EB), isolectin B4 (IB4) or laminin (LN) are used alongside simultaneous immunofluor

227 reduced in rapidly migrating growth cones on laminin (LN) compared with non-integrin-binding poly-d-l

228 Here, we investigate the efficacy of laminin (LN) isoforms preferentially expressed in the li

229 with extracellular matrix proteins including laminin (Ln)-332, produced by hepatic stellate cells (HS

230 Endocytosed laminin localizes to lysosomes, results in increased int

231 These results indicate that astrocytic laminin maintains the integrity of BBB through, at least

232 t embryonic/neonatal stage, while astrocytic laminin maintains vascular integrity in adulthood.

233 d GPR179 become dissociated, suggesting that laminins mediate scaffolding of post-synaptic components

234 sults demonstrate a novel mechanism by which laminins modulate vascular branching and endothelial cel

235 malities reminiscent of GAG biosynthesis and laminin mutants.

236 We show that netrin-4 disrupts laminin networks and basement membranes (BMs) through hi

237 These independent collagen and laminin networks are thought to be linked by several add

238 G1, an aGPCR with two domains [pentraxin and laminin/neurexin/sex hormonebinding globulin-like (PLL)

239 y unidentified domain that we term Pentraxin/Laminin/neurexin/sex-hormone-binding-globulin-Like (PLL)

240 h muscle-specific expression of alphaLNNd, a laminin/nidogen chimeric protein that provides a missing

241 detectable fibronectin and the decreases in laminin observed in vivo.

242 A peptide mimicking the binding site of laminin onto PrP(C) (Ln-gamma1) binds to PrP(C) and indu

243 sulting in inverted polarized cysts, with no laminin or type IV collagen assembly at cell/extracellul

244 ber detachment, in association with impaired laminin organization and ineffective fibronectin degrada

245 Collagen IV, pan-laminin, perlecan and laminin-alpha5 in the islet BM wer

246 al data indicated that this mutation impairs laminin polymerization, which we hypothesized to be the

247 issue of the JCI, McKee and colleagues use a laminin polymerization-competent, designer chimeric BM p

248 Large-fiber topography without laminin prevented cell migration, which was partially re

249 alled ImmunoCloak, consisting of a matrix of laminin, proteoglycans, fibronectin, and collagens.

250 sstalk between these two signaling pathways, laminin-PrP(C)-mGluR5 or AbetaO-PrP(C)-mGluR5, as well a

251 methods, to address key questions regarding laminin quaternary structure.

252 noma cells acting via 37/67 kDa non-integrin laminin receptor (LR/37/67 kDa) and downstream ERK1/2, P

253 are cross-reactive antigens that bind to the laminin receptor of the blood-brain barrier as a molecul

254 esin choline-binding protein A that binds to laminin receptor on vascular endothelial cells and bindi

255 ss of the dystrophin-glycoprotein complex, a laminin receptor that connects the myofiber to its surro

256 endently of choline binding protein A (CbpA)/laminin receptor, CbpA/polymeric immunoglobulin receptor

257 Another potential laminin receptor, dystroglycan, is at the post-synaptic

258 A potential laminin receptor, integrin alpha3, is at the presynaptic

259 -3-gallate (EGCG) signals ECs via the 67 kDa laminin-receptor (67LR) resulting in protein kinase A de

260 neuropathies, results attributed to loss of laminin-receptor signaling.

261 ly, myotubes lacking integrin alpha7beta1, a laminin-receptor, also show a significant increase in pS

262 ns act as links among pre- and post-synaptic laminin receptors and alpha-DG and pikachurin in the syn

263 Further RNAseq analysis reveals that laminin regulates PDGFRbeta(+) cell differentiation/fate

264 been shown that laminin alpha4 (endothelial laminin) regulates vascular integrity at embryonic/neona

265 We hypothesize that this laminin-related function is essential for the previously

266 Netrins, a family of laminin-related molecules, have been proposed to act as

267 Netrin-1, a laminin-related secreted protein, displays proto-oncogen

268 e that glioma migration under confinement on laminin relies on formins, including FHOD3, but not Arp2

269 of breast cancer cells in three-dimensional laminin-rich extracellular matrix (3D lr-ECM).

270 r cell migration and cell invasion through a laminin-rich matrix.

271 visible to the unaided eye but retain hollow laminin-rich tubular structures.

272 al muscle, agrin binds with high affinity to laminin(s) and alpha-dystroglycan (alpha-DG), an integra

273 rophy, acting as a link between alpha-DG and laminin(s).

274 of the subunit order typically presented in laminin schematics.

275 physiological consequences of disruption of laminin secretion in glia included decreased larval loco

276 te collagen secretion, is also important for laminin secretion in glia via a collagen-independent mec

277 ion of glial morphology due to disruption of laminin secretion.

278 However, the expression of fibronectin- and laminin-specific matrix metalloproteinases (MMPs), parti

279 overcome polymerization deficits to increase laminin, stabilize BM structure, and substantially ameli

280 the patient, the presence of both PMCA3 and laminin subunit 1alpha mutations appears to be necessary

281 es two missense mutations in LAMA1, encoding laminin subunit 1alpha.

282 ency coding variant rs2076349 (V527M) in the laminin subunit beta3 (LAMB3) gene showing strong associ

283 Glial-specific loss of the beta or gamma laminin subunit disrupted glia morphology and led to ER

284 e identified the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298.

285 The retention of the unpaired laminin subunit was key to the glial disruption as loss

286 ion, resulted in light-induced enrichment of laminin subunits alpha4 and alpha2, nidogen 1, and decor

287 Prior studies have found that loss of laminin subunits from vertebrate Schwann cells causes lo

288 Real-time PCR analysis of laminin subunits showed that spheroids formed from ancho

289 This review will summarize the structure of laminins, the modulation of their expression, and their

290 of Tango1 blocked secretion of the complete laminin trimer but did not lead to glial or locomotion d

291 However loss of secretion of the laminin trimer does not disrupt animal locomotion.

292 required for extracellular polymerization of laminin trimers and basement membrane scaffolding.

293 Adhesion of epithelial cells to laminin via integrin alpha3beta1 was previously shown to

294 associated with enhanced fibrosis (collagen, laminin, vimentin, periostin).

295 lpha3beta1 and alpha6beta1 to subendothelial laminin was a critical prerequisite for successful trans

296 d islets, yet a significant reduction in pan-laminin was seen during the initial 24 h culture period.

297 Collagen IV and pan-laminin were present in the disorganized BM of isolated

298 2-type IV collagen, gamma1-laminin and beta2-laminin, were significantly increased in patients with d

299 On laminin, which binds APP and beta1 integrins (Itgb1), DS

300 tion of polymerization-deficient recombinant laminins, with retention of collagen IV, reiterating the