ライフサイエンスコーパス: landscape

1 ed in substantial alterations to the comet's landscape.

2 nt structuring both species and genes in the landscape.

3 anding of how rates of warming vary across a landscape.

4 the fluidity of the ever-changing chromatin landscape.

5 fective response to changes in the selective landscape.

6 r date change varies considerably across the landscape.

7 ough modulating the shape of the multistable landscape.

8 can reveal new features of the recombination landscape.

9 namics through modification of the potential landscape.

10 nfluenced by the land use of the surrounding landscape.

11 netic variation in shaping the recombination landscape.

12 ceptor conformations along the OFF-ON energy landscape.

13 ractor-like structure in the inferred energy landscape.

14 ormatics approaches, will further change the landscape.

15 mpared to analogous areas in the unprotected landscape.

16 eed to have full knowledge about the fitness landscape.

17 relation through nonergodic sampling of its landscape.

18 inical evaluation may change the therapeutic landscape.

19 nment, which dynamically modulates the tumor landscape.

20 atory herds were more common features of the landscape.

21 ectories that are shown upon the free energy landscape.

22 a gradient in cover of apple orchards in the landscape.

23 construction of a coarse-grained free energy landscape.

24 ricate germline-somatic-immunity interaction landscape.

25 e in blocking modifications to the chromatin landscape.

26 y substantial sources of trace metals to the landscape.

27 lly compatible with the networks' reputation landscape.

28 its rapidly increasing footprint across the landscape.

29 poor-prognosis tumors with a complex genomic landscape.

30 ss is most detrimental in already fragmented landscapes.

31 ssing of fearful faces compared with neutral landscapes.

32 settled across western Eurasian cold-climate landscapes.

33 se scans with published experimental fitness landscapes.

34 ty dependence, b', was lower in good quality landscapes.

35 ial ecology of lake sturgeon in unfragmented landscapes.

36 ldlife coexistence across large multiple-use landscapes.

37 otocol to generate potential energy vs. RMSD landscapes.

38 ing is closely related to specific chromatin landscapes.

39 umors with characterized insertional genetic landscapes.

40 model (AWSEM) to construct their free energy landscapes.

41 s is challenging in heterogeneous fragmented landscapes.

42 hese species, whereas deforestation degrades landscapes.

43 Callosobruchus maculatus across experimental landscapes.

44 Today's media landscape affords people access to richer information th

45 urons and the 3' untranslated region (3'UTR) landscapes after unilateral sciatic nerve entrapment (SN

46 fication; (ii) performing spatially explicit landscape analyses to identify environmental drivers of

47 udy provides new insights into the chromatin landscape and Blimp1-dependent regulatory networks gover

48 Here we assess the current landscape and challenges in the treatment of antibiotic

49 of these lesions is affected by the genomic landscape and contributes to mutagenesis is unknown.

50 , which results in a change in the chromatin landscape and enhanced transcription.

51 entations, thus tuning the overall energetic landscape and ensuring highly efficient light-harvesting

52 iour through manipulation of the vibrational landscape and orientational order of the superatoms.

53 ospheric concentrations across a large urban landscape and specific knowledge gaps at the intersectio

54 sentations of the conformational free energy landscape and the complex folding mechanism inherent to

55 By mapping changes in enhancer landscape and transcription factor occupancy (using ChIP

56 s in signal-specific alterations in enhancer landscapes and associate with coordinated binding of CEB

57 is problem by considering general classes of landscapes and calculating an upper limit for the time i

58 of fitness and related ideas such as fitness landscapes and evolutionary optima.

59 -initiating cells possess distinct chromatin landscapes and gene regulatory networks associated with

60 ontrol over hydrological processes in Arctic landscapes and lakes.

61 lls are characterized by aberrant epigenetic landscapes and often exploit chromatin machinery to acti

62 d due to the heterogeneous nature of dryland landscapes and the desiccation tolerance of biocrusts, w

63 was much more abrupt than in poorer quality landscapes and the realized strength of density dependen

64 ar cues determine highly specific epigenetic landscapes and transcriptional profiles to promote immun

65 bed to their hierarchical and fractal energy landscape, and is also different from [Formula: see text

66 alterations in DNA methylation, the histone landscape, and transcriptional reprogramming that occur

67 e that promote homogeneous, species-depleted landscapes; and (g) deliberate culture and release of mo

68 This Letter to the Editor clarifies the landscape approach as an ethic for land management, demo

69 The landscape approach is thus poised to become one of the m

70 nd methods for landscape restoration and the landscape approach.

71 development and empirical assessment of the landscape approach.

72 Unlike human tumors, the GEMM genomic landscapes are dominated by copy number alterations, whi

73 in the comparison of different phylogenetic landscapes are presented.

74 ranscription and a more accessible chromatin landscape around genes involved in detoxification pathwa

75 1940, Waddington coined the term "epigenetic landscape" as a metaphor for pluripotency and differenti

76 almost complete remodeling of the chromatin landscape, as well as alteration of the transcriptional

77 data and simulate bird movement within this landscape based on simple decision rules drawn from stat

78 Energy landscapes based on F-actin-tropomyosin models show the

79 for probing their complex 3D conformational landscape, both experimentally and computationally.

80 different between natural and anthropogenic landscapes, but community phenologies differed strongly,

81 pling followed by sequence design and energy landscape calculations.

82 These two landscapes can be quantified through the decomposition o

83 m(-2) is the dominating contribution to the landscape CH4 emission of 7 g CH4 m(-2) .

84 es depends critically upon understanding how landscape change affects key population-level parameters

85 opulations from rural to urban living causes landscape changes and alters the functionality of soil e

86 The effects of these energy landscape changes on the conformational ensemble are par

87 considered as essential to survival in such landscapes, changes in the nasal morphology and/or funct

88 The POU2F2 and TRIM28 co-expressed lncRNA landscape characterized here may shed light into normal

89 We state that these two landscapes complement each other with one crucial for st

90 The resulting detailed conformational landscapes complement in an integrative manner the avail

91 combination of wetlands and shallow bays as landscape components that determine the function of estu

92 e near-comprehensive single-mutation fitness landscapes comprising >96.3% of all possible single nons

93 olding model derived from theoretical energy landscape considerations and the defined-pathway model d

94 f-organized connectivity, defining a "neural landscape" consisting of a task-tailored arrangement of

95 ubstrates with an optimized flat free energy landscape containing all binding motifs allows determina

96 Landscape context strongly predicted focal crop pollen f

97 ariant trait, but rather one that depends on landscape context.

98 context of ongoing climatic warming, certain landscapes could be near a tipping point where relativel

99 ial population due to the historic selective landscape created by the widespread use of other antibio

100 Navigation of the conformational landscape defined by this bioinformatics-based study is

101 The resulting mutational landscape demonstrates that large portions of antibody v

102 A complex conformational energy landscape determines G-protein-coupled receptor (GPCR) s

103 ogenic land surface processes (LSPs) control landscape development, ecosystem functioning and climate

104 ibrillar pentamer in the Abeta40 aggregation landscape disappears for Abeta42, suggesting that the Ab

105 arge into the Gulf of Alaska originates from landscapes draining glacier runoff, but the influence of

106 the importance of regulating the epigenetic landscape during cell fate conversion but also provide a

107 CBP/p300 sequentially shape dynamic enhancer landscapes during cell differentiation.

108 regime shifts for models that detail fitness landscape dynamics, we find that our quantitative result

109 eveloped an analytical framework informed by landscape ecology and catchment hydrology to quantify sp

110 Inspired by concepts from landscape ecology and Markowitz's portfolio theory, we d

111 Landscape ecology examines the relationships between the

112 This quantitative landscape enables a proteome-wide classification of 986

113 ial for anthropogenic pressures to shape the landscape epidemiology of HeV spillover.

114 nt-transport dynamics, to simulate potential landscape evolution at three locations in the Kalahari D

115 We use a numerical landscape evolution model to demonstrate that short-wave

116 d subsequently fitted, along with additional landscape factors, to HeV spillovers to explore the spat

117 nation by aerial delivery is associated with landscape features.

118 lso contributed to the p300-bound regulatory landscape following hybridization and whole-genome dupli

119 Although the treatment landscape for advanced melanoma has changed since this s

120 having 20 or 30 glutamines, the aggregation landscape for fragments with 40 repeats has become downh

121 eflecting how S672R remodels the free energy landscape for the modulation of HCN4 by cAMP, i.e. the p

122 ve characterization of the rat GI microbiota landscape for the research community, laying the foundat

123 ations on plant migration and the impacts of landscape fragmentation.

124 We define an environmental potential landscape from environmental data and simulate bird move

125 success in revealing genome-wide regulatory landscapes from temporal gene expression data, especiall

126 ormation theory, we derive epigenetic energy landscapes from whole-genome bisulfite sequencing (WGBS)

127 enges and practical prospects for the use of landscape genetics and genomics to understand the biolog

128 odels with approaches from movement ecology, landscape genetics/genomics and ecoimmunology may provid

129 ctome' provides insights into the functional landscape governing CE systems essential to bacterial gr

130 e also produced in more diverse agricultural landscapes (H>1.5).

131 ), and cereals (56%) are produced in diverse landscapes (H>1.5).

132 We show that these diverse subglacial landscapes have an impact on ice flow, and present a cha

133 potency and differentiation, but methylation landscapes have not yet been rigorously computed.

134 contact rate can arise from host, group and landscape heterogeneity and can result in different patt

135 adaptive evolution depending on the fitness landscape; however, direct experimental support is limit

136 nsequences for how pathogens transmit across landscapes; however, discerning different transmission r

137 Rapid sequences of landscape images were presented to thirty-one male parti

138 ndem repeat arrays on the recombination rate landscape in an avian speciation model, the Eurasian cro

139 haracterize the whole-genome DNA methylation landscape in human pancreatic islets, to identify differ

140 ounts of forest in an extensively deforested landscape in southern Costa Rica.

141 We sought to construct the immunologic landscape in the airways of children with severe asthma.

142 , we examined the epigenome and the enhancer landscape in X. tropicalis x X. laevis hybrid embryos.

143 ts as FANTOM and ENCODE, forming genome-wide landscapes in a series of human cell lines.

144 RALDH3 establish dynamic retinoic acid (RA) landscapes in feather mesenchyme, which modulate GREM1 e

145 revealed unanticipated complex translational landscapes in metazoans.

146 de a useful strategy for altering epigenetic landscapes in organisms where histone methyltransferases

147 Exploration of fitness landscapes in the context of a protein fold provides a s

148 Here we analyzed changes in the ubiquitin landscape induced by endometrial cancer-associated SPOP

149 n ignorant of the full extent of the genetic landscape involved in auditory dysfunction.

150 at active maintenance of a precise chromatin landscape is essential for sustaining proper leukemia ce

151 a more complete depiction of how the variant landscape is shaped in C. elegans.

152 This funneled energy landscape is the result of foldable protein sequences ev

153 A model enzyme for the study of reaction landscapes is lactate dehydrogenase.

154 e been used to map the complex thermodynamic landscape leading to growth of the two distinct steps, a

155 abolism, and modifications of the epigenetic landscape, leading to cellular dedifferentiation, enhanc

156 ch as biological control, are susceptible to landscape-level changes.

157 g on virus subtypes, which can manifest into landscape-level effects.

158 climatic refugia) is in currently protected landscapes (<1-9%).

159 d on optimal control theory and Waddington's landscape metaphor to provide an integrated view of this

160 warmer organic soils is expected to increase landscape methane (CH4 ) emissions.

161 Climate landscape metrics, which signal the spatial magnitude an

162 species-specific, spatially explicit forest landscape model (LANDIS-II) to evaluate forest response

163 al network are used as an input to an energy landscape model for chromatin organization [Minimal Chro

164 A basic tenet of the energy landscape model is that proteins fold through many heter

165 We used a physiologically based mechanistic landscape model to study these interactions in the north

166 We call the model ELM for "energy landscape model." In ELM, the interaction of the wave pa

167 evious work on meta-foodwebs has focussed on landscape networks that do not have an explicit spatial

168 To inform more ecologically based landscape nutrient management, we compared watershed inp

169 o case studies on the computed probabilistic landscape of a gene regulatory network and of a toggle-s

170 tional study unravels the folding-functional landscape of a natural thermosensor protein, the molecul

171 es require robust elucidation of the genomic landscape of a patient's cancer and, ideally, the abilit

172 Over the past decades, the landscape of adult congenital heart disease has changed

173 e-scale studies that assess both the genomic landscape of alterations within tumor cells and the comp

174 The folding energy landscape of an RNA is highly dependent on its nucleotid

175 ur aim in this study was to characterize the landscape of anaerobic infections in HS using high-throu

176 immunotherapy have dramatically changed the landscape of available treatment options for patients wi

177 We explored the landscape of BCAs at nucleotide resolution in 273 subjec

178 methods to determine the protein interaction landscape of BIA 10-2474 in human cells and tissues.

179 Prep1 DR expands the DNA binding landscape of C/EBPbeta (CCAAT enhancer binding protein b

180 The complicated, evolving landscape of cancer mutations poses a formidable challen

181 Immunotherapy has changed the landscape of cancer treatment.

182 The analysis of the mutational landscape of cancer, including mutual exclusivity and co

183 armer admixture that transformed the genetic landscape of central Europe, suggesting that changes ass

184 The heavily mutated landscape of coding and non-coding mutations in cutaneou

185 hensive sequencing have revealed the genomic landscape of common forms of human cancer in unprecedent

186 o a core TRM, broadly found across the whole landscape of CRMs, to discriminate promoters from enhanc

187 , pluripotent stem cells (PSCs) sit atop the landscape of developmental potency and are characterized

188 e tumor genome showed a highly heterogeneous landscape of genetic perturbations, and transcriptome an

189 Such rare somatic variants dominate the landscape of genomic mutations in cancer, yet efforts to

190 Our study provides a functional landscape of gliomagenesis suppressors in vivo.

191 Here, we establish the landscape of human cell-specific microRNA expression.

192 PCR assays capable of capturing the genomic landscape of human centromeres at a given time.

193 We analyzed to what extent the proteomic landscape of human colorectal cancer (CRC) is maintained

194 Unfortunately, the landscape of human E3-substrate network has not been sys

195 ively characterize the genomic and molecular landscape of insulinomas relative to normal beta cells.

196 The whole-genome mutation landscape of melanoma reveals diverse carcinogenic proce

197 undances (leaf litter) using an experimental landscape of mesocosms, and assayed colonization by 35 s

198 g a powerful tool to investigate the genetic landscape of metabolic phenotypes.

199 ts have begun to dissect the complex genomic landscape of MIBC, revealing distinct molecular subtypes

200 A dramatic, heterogenous landscape of molecular species was revealed, demonstrati

201 A quantitative landscape of morbidity of survivors, however, has not be

202 amework of the transcriptomic and epigenomic landscape of mouse and human keratinocytes.

203 ut continuous reorganization of the adaptive landscape of mutualistic partners under changing environ

204 To better understand the genomic landscape of non-DS-AMKL, we performed RNA and exome seq

205 has the potential to dissect the functional landscape of noncoding regions, but is highly susceptibl

206 et al. (2017) demonstrate that studying the landscape of open chromatin regions in stem cell-derived

207 l models, Doehl et al. argue that the patchy landscape of parasites in the skin is necessary to expla

208 adult MDS, little is known about the genomic landscape of pediatric MDS.

209 ibution along the chromosomes constrains the landscape of potential genetic combinations.

210 However, the landscape of PT and TPS genes in plant genomes is unclea

211 as a roadmap into the vast and exciting new landscape of questions about the computations, structura

212 The novel mutational landscape of quiescence is characterized by insertion/de

213 t feasible and cost-effective to explore the landscape of regulatory activity in the much larger huma

214 The genomic landscape of schwannoma is complex and many of the molec

215 s give an interesting overview of the varied landscape of SI in sustainability science, ranging from

216 This study provides a landscape of TFs in mouse tissues that can be used to el

217 This study suggests that the overall landscape of the BNSTALG in the primate and mouse may be

218 h we can now describe the complete energetic landscape of the Cdc42-binding site on ACK.

219 To assess the current landscape of the heart failure (HF) epidemic and provide

220 bes are critical for establishing the immune landscape of the lungs.

221 Histone H1 shifts the conformational landscape of the nucleosome by drawing the two linkers t

222 nd magnesium ions on the folding free energy landscape of the SAM-I riboswitch.

223 Together, these results reveal the dynamic landscape of the stimulus-dependent transcriptional chan

224 Here, we report the landscape of the tomato virome in China, the leading cou

225 Our TCF approach reveals a complex landscape of thermodynamic coupling between Na(+) releas

226 ea slug, and coral to examine the functional landscape of this enigmatic genus.

227 To more fully characterize the genomic landscape of this tumor type, we performed next generati

228 ma and provide new insights into the genomic landscape of tumor cells that survive and initiate tumor

229 omic (ATAC-seq) and transcriptomic (RNA-seq) landscapes of alphaTC1 and betaTC6 cells.

230 ed our capacity to interrogate the molecular landscapes of human cancers, including childhood brain t

231 Particularly controversial are landscapes of overdispersed (evenly spaced) elements, su

232 eport a genome-wide assessment of regulatory landscapes of primary human aortic endothelial cells (HA

233 oadly used to gain insight into how changing landscapes of protein-protein associations affect the ph

234 to the high complexity of the conformational landscapes of proteins and their rugged energy levels.

235 work analysis, and functional studies define landscapes of the T cell proteome and phosphoproteome an

236 into contemporary diets and how the nutrient landscapes of these staples vary as a function of cultiv

237 l makeup of species by affecting the fitness landscapes on which they evolve.

238 Landscape patterns of infestation depend on MPB dispersa

239 be neatly expressed by the potential energy landscape (PEL).

240 d Markowitz's portfolio theory, we develop a landscape portfolio platform to quantify and predict the

241 Here we provide the first landscape predictive model for CWD based solely on soil

242 strong foundational knowledge of the immune landscape present in NSCLC.

243 les of Tet2 in maintaining the transcriptome landscape related to neurogenesis.

244 and vegetation cover play in shaping dryland landscapes, relatively little is known about how dryland

245 n such complex and variable natural resource landscapes remains poorly understood.

246 Objectives, assumptions, and methods for landscape restoration and the landscape approach.

247 d management, demonstrates how it relates to landscape restoration, and motivates continued theoretic

248 m mechanical calculations of the free energy landscapes reveal how the neutral inhibitors provide sha

249 riven by declining population density at the landscape scale rather than sudden and widespread range

250 At the landscape scale, the coastal wetlands of the South East

251 structure soil fungal communities following landscape-scale insect outbreaks and reflect the indepen

252 However, landscape-scale patterns and drivers of shrub expansion

253 hat 6mA is an integral part of the chromatin landscape shaped by adenosine triphosphate (ATP)-depende

254 s to predict that magnesium ions remodel the landscape, shifting the equilibrium away from the extend

255 f the histone posttranslational modification landscapes show significant overlap with the genetic ris

256 included the repeated use of caves and open landscape sites.

257 rns of tree-layer variability at even larger landscape spatial scales (>/=1000s of ha) promises to re

258 ng engineering of rapid changes in the force landscape, storing and processing information, and ultim

259 se front as indicated by several measures of landscape structure (e.g., number of patches) relative t

260 of the rapidly changing political and legal landscape surrounding use of cannabis products in the US

261 thirty-one male participants with occasional landscape targets (rotated images).

262 iates tree mortality in certain parts of the landscape that are low and convergent, likely through in

263 d 3) discover small peaks in the probability landscape that have potential relation to specific disea

264 ionary dynamics by transforming the adaptive landscape that relates genotype to fitness.

265 of forest products shaped a largely forested landscape that survived intact until the late 20th centu

266 ps highlights several key differences in the landscapes that can be attributed to the two additional

267 explores the global health and public policy landscapes that intersect with women's health and global

268 ated to complex, nonexperimental, real-world landscapes that provide ecosystem services to humans rem

269 ognosis are determined by a specific genomic landscape, that is, type of MPN driver mutations, associ

270 The richness of species associated with open landscapes, that had been maintained for centuries by tr

271 e an explicit spatial embedding, but in real landscapes the patches are usually distributed in space.

272 In good quality landscapes, the onset of strong density dependence was m

273 Energy landscape theory, developed in the context of protein fo

274 We show that for additive landscapes there is a critical selection strength enabli

275 ellular molecules sometimes alter the energy landscape, thereby changing the ensemble of likely low-e

276 Energy landscape thinking raises new questions about the nonequ

277 Humans homogenize landscapes through deforestation, agriculture, and burni

278 he shape of the monkeys' vocal developmental landscape, tilting, rotating or shifting it in different

279 such states enabled the folding free-energy landscape to be deduced.

280 rent DNA damage contributes to the chromatin landscape to ensure the epigenomic integrity of dividing

281 rong topographic and hydrologic signature at landscape to global scales.

282 ing and thereby might reduce the capacity of landscapes to provide archives of climate change.

283 or quantifying edge impacts in heterogeneous landscapes to quantify edge-determined changes in abunda

284 animals looking for food or mates in natural landscapes, to rescuers during search and rescue operati

285 n activity could strongly exacerbate certain landscape trajectories.

286 t provides ecosystem-sustaining nutrients to landscapes underlain by intensively weathered soils.

287 Chasing HIV-1 across the genotype landscape, unequipped to anticipate its maneuvers, the a

288 on information collected for segments of the landscape using LD simulations and experimental informat

289 Instead of postulating a particular fitness landscape, we address this problem by considering genera

290 Despite covering only 5% of the landscape, we estimate that aquatic C. aquatilis and A.

291 tivity of alpha-SYN in its native epigenetic landscape which is not achievable using exogenous transf

292 enhance freshwater biodiversity in urbanized landscapes whilst also facilitating key ecosystem servic

293 ether tree mortality across drought-stricken landscapes will be concentrated in particular climatic a

294 However, delivering such landscapes will probably require the explicit linkage of

295 n dynamics (LD) simulations on a very coarse landscape with a single rate-limiting barrier and reprod

296 preestablished tumors showed that a complex landscape with optimal stroma permeabilization and immun

297 nternal exposure of aquatic organisms across landscapes with differing pH.

298 to invertebrate scavengers, particularly in landscapes with efficient vertebrate scavenging communit

299 llinator abundance and yield were reduced in landscapes with high cover of apple orchards.

300 evelopment introduces new land uses into the landscape, with unknown repercussions for local communit

301 et al. and Yang et al. unravel new molecular landscapes within the dermal papilla.