ライフサイエンスコーパス: lanthionine

1 of the two peptides of bicereucin contains a lanthionine.

2 ndenses two molecules of cysteine, generates lanthionine.

3 e, and CSE, but not CBS, efficiently cleaves lanthionine.

4 ety of orthogonally protected derivatives of lanthionine 1.

5 Lanthionine, a thioether analogue of cystine, is a key c

6 -OH (1d), where Ala(L) and Val(L) denote the lanthionine amino acid ends linked by a monosulfide brid

7 L7]-Thr8-NH2, where AlaL denotes each of the lanthionine amino acid ends linked by the monosulfide br

8 mutants, M. smegmatis strain PM440, utilizes lanthionine, an unusual bacterial metabolite, in place o

9 stability toward enzymatic degradation, the lanthionine analog has a 2.4 times longer half-life than

10 r peptide-bound dehydroalanine (Dha) to form lanthionine, analogous to the reaction catalyzed by LanC

11 PI and MVD assays revealed that the dimethyl lanthionine analogues 1b and 1d, denoted as D-Val(L) in

12 It contains one methyl-lanthionine and four lanthionine bridges and inhibits ce

13 Lanthionine and methyllanthionine bridges, closing the m

14 he resulting unsaturated amino acids to form lanthionine and methyllanthionine bridges, respectively.

15 d that, like cytolysin, carnolysin contained lanthionine and methyllanthionine residues of unusual st

16 These polycyclic peptides contain lanthionine and methyllanthionine residues that result i

17 The stereochemistry of the lanthionine and methyllanthionine residues was determine

18 were established, and the topologies of the lanthionine and methyllanthionine rings were determined.

19 highly cyclized lantibiotic, containing six lanthionine and methyllanthionine rings, three of which

20 e discovery of lantibiotics with alternative lanthionine and methyllanthionine stereochemistry has pr

21 tack the dehydrated residues to generate the lanthionine and methyllanthionine thioether cross-linked

22 ationally modified, and are characterized by lanthionine and methyllanthionine thioether cross-links.

23 are characterized by the unique amino acids lanthionine and methyllanthionine, introduced by means o

24 sidues to generate the thioether cross-links lanthionine and methyllanthionine, respectively.

25 e of the thioether-containing bisamino acids lanthionine and methyllanthionine.

26 ence of the thioether-containing amino acids lanthionine and methyllanthionine.

27 tion of the thioether-containing amino acids lanthionine and methyllanthionine.

28 ications, including the thioether structures lanthionine and methyllanthionine.

29 ing the characteristic thioether cross-links lanthionine and methyllanthionine.

30 One dehydroalanine, one lanthionine and three beta-methyl-lanthionine residues w

31 y cysteines to form cyclic thioethers termed lanthionines and methyllanthionines.

32 predicted to be virtually the sole source of lanthionine, and CSE, but not CBS, efficiently cleaves l

33 Lanthionine antibiotics are an important class of natura

34 ondensation of 2 mol of cysteine to generate lanthionine, are quantitatively less significant.

35 sted the proposal that LanCL1 is involved in lanthionine biosynthesis by constructing LanCL1 knock-ou

36 ting that LanCL proteins are not involved in lanthionine biosynthesis.

37 goadsporin, this dehydration is catalyzed by lanthionine biosynthetic enzyme B (LanB) or LanB-like pr

38 hree beta-methyl lanthionine bridges and one lanthionine bridge and demonstrated limited antibiotic a

39 of cyclic somatostatin analogs containing a lanthionine bridge have been subjected to studies of str

40 modification of sandostatin by introducing a lanthionine bridge resulted in a significantly increased

41 e amino acids in positions 7 and 27 form the lanthionine bridge, giving a globular conformation to th

42 isulfide group is replaced by a monosulfide (lanthionine) bridge (D-Phe1-c[AlaL2-Phe3-D-Trp4-Lys5-Thr

43 study we report the solid-phase synthesis of lanthionine-bridged analogues of ProTx-II, in which one

44 ive cyclization on resin to give the desired lanthionine-bridged peptide.

45 It contains one methyl-lanthionine and four lanthionine bridges and inhibits cell wall biosynthesis

46 However, SapT, which bears three beta-methyl lanthionine bridges and one lanthionine bridge and demon

47 The beta-methyl-lanthionine bridges are established between residues 12-

48 tion of four dehydroalanine residues and two lanthionine bridges.

49 ws preparation of more than 10(11) different lanthionine containing peptides.

50 ed peptide bacteriocins called lantibiotics (lanthionine-containing antibiotics) and is produced by t

51 Lacticin 481 is a lanthionine-containing bacteriocin (lantibiotic) produce

52 Finally, the identification of a second lanthionine-containing morphogenetic peptide suggests th

53 Lanthionine-containing peptides (lanthipeptides) are a f

54 ynthesis in the oceans-produces many cyclic, lanthionine-containing peptides (lantipeptides).

55 responsible for the synthesis of thioether (lanthionine) cross-links within nascent polypeptide chai

56 ilities of PM440 to grow without DAP and use lanthionine for peptidoglycan biosynthesis result from a

57 have also demonstrated that the synthesis of lanthionine from trityl-protected beta-iodoalanines is p

58 We also show that the lanthionine group is a good mimetic of beta-VI turns and

59 es had the (2S,3S,6R) configuration, and the lanthionines had the (2S,6R) configuration, irrespective

60 Lanthionine has been detected in human brain as the down

61 (1) of sandostatin (SMS 201,995) and several lanthionine hexa-, hepta-, and octapeptides was carried

62 ighly dependent on the presence of a (2S,6R)-lanthionine in the peptide and an active conformation of

63 We then used this orthogonally protected lanthionine in the solid-phase synthesis of an analogue

64 unobu reaction, that gave the single desired lanthionine, in complete regio- and diastereoselectivity

65 The most direct approaches to lanthionine involve the reaction of cysteine with an ala

66 Lanthionine ketimine (LK) represents a poorly understood

67 in human brain as the downstream metabolite lanthionine ketimine (LK), which has been shown to have

68 They contain lanthionine (Lan) and methyllanthionine (MeLan) residues

69 They contain characteristic lanthionine (Lan) or methyllanthionine (MeLan) structure

70 xidation of the sulfur-containing amino acid lanthionine, limiting their use.

71 dehydroalanine (Dha), dehydrobutyrine (Dhb), lanthionine (Ln), and methyllanthionine (MeLn), are poor

72 es of enkephalin analogues incorporating the lanthionine modification are presented.

73 The lanthionine octapeptide with C-terminal Thr-ol (1) showe

74 Similarly, the lanthionine octapeptide with the C-terminal Thr-NH2 resi

75 e have explored two synthetic routes to give lanthionine, orthogonally protected with Alloc/allyl and

76 anine, one lanthionine and three beta-methyl-lanthionine residues were found in its 27 amino acid seq

77 ionally modified peptides containing (methyl)lanthionine residues.

78 This is the first time a synthetic lanthionine ring analogue of a lantibiotic has retained

79 providing access to the regioselectivity of lanthionine ring formation using high-resolution tandem

80 nalogues containing either desmethyl- or oxa-lanthionine rings confirm that the precise geometry of t

81 directional fashion, forming a total of four lanthionine rings in its HalA2 substrate.

82 nd thioether amino acids that introduce five lanthionine rings into the target peptide.

83 The metabolic stability of lanthionine-sandostatin and sandostatin have been studie

84 s linked by a monosulfide bridge to form the lanthionine structure, were successfully carried out via

85 one S-transferase-mu (GST-mu) and GST-pi and lanthionine synthase C-like protein-1 (LanCL1).

86 and the presence of 77 other genes (CRISPR, lanthionine synthase, glutathione synthetase, catalase,

87 chlorosins are formed enzymatically by ProcM lanthionine synthetase and not by a nonenzymatic process

88 or-activated receptor gamma (PPAR gamma) and lanthionine synthetase C-like 2 (LANCL2) as molecular ta

89 In this study, we identify the lanthionine synthetase C-like 2 (LanCL2) protein as a po

90 Lanthionine synthetase C-like 2 (LANCL2), a novel therap

91 volving peptide substrates, the prochlorosin lanthionine synthetase evolves under a strong purifying

92 the prochlorosin peptide substrates and the lanthionine synthetase suggests that structure diversifi

93 ently discovered glutathione-binding protein lanthionine synthetase-like protein-1.

94 us and diverse lanthipeptides using a single lanthionine synthetase.

95 We demonstrate that several lanthionine synthetases catalyse highly selective anti-a

96 is most likely a plant homolog of bacterial lanthionine synthetases.

97 that also has 2 dangling carboxylate groups, lanthionine, to form (99m)Tc(CO)(3)(LAN), a new renal ra

98 n of the cytolysin subunits and detection of lanthionine-type post-translational modifications within

99 e allyl and Alloc groups of the incorporated lanthionine unit was followed by regio- and stereoselect

100 a new approach to the synthesis of protected lanthionine, using a novel variant of the Mitsunobu reac

101 Lanthionine was systematically replaced with diaminopime

102 ty of the peptide by replacing the sulfur in lanthionine with a methylene unit.