ライフサイエンスコーパス: large T antigen

1 te specificity for conserved epitopes of JCV large T antigen.

2 all three mutant particles failed to express large T antigen.

3 on by its physical association with the SV40 large T antigen.

4 om an Rb family member by Hsc70 recruited by large T antigen.

5 non-neoplastic hepatocytes transformed with large T antigen.

6 nactivation by the putative presence of SV40 large T antigen.

7 n to be a binding target of the polyomavirus large T antigen.

8 0 proteins, Escherichia coli Hsc20 and viral large T antigen.

9 of fibroblasts to transformation by the SV40 large T antigen.

10 ouse model expressing low levels of the SV40 large T antigen.

11 protein small T antigen (sTAg) and truncated large T antigen.

12 3 and expressed a temperature-sensitive SV40 large T antigen.

13 La cell-free extract in the presence of SV40 large T antigen.

14 tion, transfected into cells expressing SV40 large T antigen.

15 ssed in cells expressing the simian virus 40 large T antigen.

16 SV40 immediate early gene, which encodes the large T antigen.

17 acilitate the transforming potential of SV40 large T antigen.

18 fic antisense agent against the mRNA of SV40 large T antigen.

19 uct (p150(sal2)) as a binding partner of the large T antigen.

20 mors in transgenic mice expressing truncated large T antigen.

21 sformation with viral oncogenes such as SV40 large T antigen.

22 ion with adenovirus E1A and simian virus s40 large T antigen.

23 d the origin-binding domain of virus-encoded large T antigen.

24 nd alternatively spliced 57kT forms of MCPyV large T antigen.

25 MCPyV genome has undergone mutations in the large T antigen.

26 rom MLD patients were transformed using SV40 large T antigen.

27 cur in MCC tumors that fail to express MCPyV large T antigen.

28 and expresses small T antigen and truncated large T antigen.

29 sion and in only 1 of 56 tumors positive for large T antigen.

30 lar immune response to peptides encoding BKV large T antigen.

31 es and immortalized with telomerase and SV40 large T antigen.

32 r localization signals derived from the SV40 large T-antigen.

33 ncreases in the cellular amounts of the SV40 large T-antigen.

34 immortalization after transfection with SV40 large T-antigen.

35 CAF acetylates large T antigen in vitro, and large T-antigen acetylation in vivo is dependent upon th

36 SV40 large T antigen (Ag) binds to all members of the retinob

37 d Solt and Farber model and the albumin-SV40 large T antigen (Alb-SV40) transgenic rat.

38 be overcome by the introduction of the SV40 large T antigen, all characteristics of senescent cells.

39 In contrast, large T antigen alone is sufficient to induce tumors in

40 Other polyomavirus-encoded large T antigens also increase the levels of CBP/p300 an

41 ild-type and J domain mutant simian virus 40 large T antigens alter the cell cycle and bud morphology

42 epithelial cells with temperature-sensitive large T antigens (analogously normal) and ovarian surfac

43 tion and viral oncogenes, including the SV40 large T antigen and human papilloma virus 16 E6-antigen.

44 cell line by sequential introduction of SV40 large T antigen and human telomerase into human angiomyo

45 ells immortalized with temperature-sensitive large T antigen and human telomerase reverse transcripta

46 a binding partner of the mouse polyoma virus large T antigen and later shown to possess tumor suppres

47 d Cajal body numbers, and expression of SV40 large T antigen and oncogenic Ras.

48 On the other hand, SVST complements large T antigen and Ras for the transformation of human

49 scuss the effects of the interaction between large T antigen and Rb proteins in JC virus-mediated onc

50 It is predicted to encode the large T antigen and small T antigen early proteins and t

51 anocytes previously immortalized by the SV40 large T antigen and telomerase.

52 The fraction of cells expressing SV40 large T antigen and the levels of T antigen mRNA were re

53 l SF3 helicases, such as the simian virus 40 large T antigen and the papillomavirus E1 protein, are a

54 ortalized by the addition of simian virus 40 large T antigen and the telomerase subunit hTERT, but ha

55 retroviruses encoding Ha-Ras(G12V) and SV40 large T antigen and transplanted in immunodeficient mice

56 well as viral proteins such as polyomavirus large T-antigen and HIV-1 Tat.

57 se viruses encodes the transforming proteins large T-antigen and small t-antigen, which are involved

58 scriptional level and requires both the SV40 large T-antigen and the small t-antigen.

59 ial (NHBE) cells expressing telomerase, SV40 large T antigen, and activated Ras were immortal, formed

60 l structure of the hexameric helicase of JCV large T antigen (apo) and its use to drive the structure

61 functions of full-length and truncated MCPyV large T antigen are unknown.

62 We further show that the BKPyV large T antigen, as well as large T antigens from relate

63 le-molecule and ensemble assays to show that large T antigen assembled on the SV40 origin unwinds DNA

64 SV40 large T antigen associates with a cellular phosphoprotei

65 This enzyme binds to SV40 large T antigen at two places, close to the N-terminal e

66 l7), has been isolated as an simian virus 40 large T antigen-binding protein.

67 freely access helix III and the HPD motif of large T antigen bound to an Rb family member.

68 Expression of MDM2 or SV40 large T antigen, but not E7 nor oncogenic ras, overcomes

69 JCV large T antigen, but not VP1 capsid protein, was express

70 rons were positive for early SV40 transcript large T antigen, but only 4 of the 14 cases exhibited la

71 y developing antibodies capable of detecting large T antigen by immunohistochemistry.

72 In contrast, expression of the MCPyV large T antigen C-terminal 100 residues could inhibit th

73 y region and the genomic region encoding the large T-antigen C terminus (T-ag-C) may exhibit consider

74 We show that the oncogenes simian virus 40 large T antigen, c-Myc, and cyclin E induce spatial reor

75 Simian virus (SV) 40 large T antigen can both induce tumors and inhibit cellu

76 However, we have observed that SV40 large T antigen can induce cell proliferation and transf

77 iments, we found that simian virus 40 (SV40) large T antigen can mediate the same function.

78 A viral oncoprotein, SV40 large T antigen, can reverse prohibitin-mediated suppres

79 e isolated a novel mouse hepatocellular SV40 large T-antigen carcinoma cell line, MHT that maintains

80 se reverse transcriptase (hTERT) and/or SV40 large T antigen cDNA vectors, and antibiotic-resistant c

81 on to the expected reduction in the level of large T antigen, cells shifted to 39 degrees C show incr

82 The inability of some large-T-antigen chimeras to promote DNA replication and

83 lonal antibody directed against the BK virus large T-antigen (clone BK.T-1) has previously been used

84 he late DNA strand overlapping the 3' end of large T antigen coding sequences.

85 When the large T-antigen coding sequence was eliminated but the T

86 uestration of p53 and Rb proteins using SV40 large T antigen completely rescued necrotic cell death.

87 They express SV40 large T antigen, confirming their derivation from the pa

88 with the hexameric replicative helicase SV40 large T antigen, constituting a simple primosome that is

89 Simian virus 40 large T antigen contains an amino terminal J domain that

90 The simian virus 40 large T antigen contributes to neoplastic transformation

91 Polyomavirus large T antigen coprecipitates with p53 phosphorylated o

92 that recovery of cellular immune response to large T antigen corresponds with resolution of active BK

93 MCPyV large T antigen could bind to Rb but was unable to bind

94 e JCV standards sequenced in this study with large T antigen deletions were cultured in cell lines im

95 ivity, RAX can positively regulate both SV40 large T antigen-dependent DNA replication and transcript

96 ene products such as adenovirus E1A and SV40 large T antigen depends on their ability to inactivate p

97 that were immortalized with simian virus 40 large-T antigen differed from nonimmortalized MECs in th

98 We did PCR-based analysis to detect SV40 large T antigen DNA in human mesotheliomas.

99 he 3' untranslated region (UTR) of the BPCV1 large T antigen early transcript and identified a functi

100 However, when coexpressed with the SV40 large T antigen, EGFr accelerated tumor growth and conve

101 ically informative amino acid changes in the large T antigen exceeds even that of the VP1 region.

102 Large T antigen expressed from plasmids without the vira

103 rts of transgenic mice and embryos with SV40 large T antigen expressed in the heart-forming region.

104 cells in combination with wild-type or SV40 large T antigen expressing epithelia resulted in prostat

105 nt of telomere attrition in a subset of SV40 large T-antigen-expressing cystadenoma cells.

106 fluorescence) and the cellular levels of BKV large T antigen expression (detected by Western blot ana

107 of TP53 in the two MCC specimens that lacked large T antigen expression and in only 1 of 56 tumors po

108 Ellagic acid and spiperone also inhibited large T antigen expression by BK virus and JC virus, two

109 ubset of mesotheliomas was analyzed for SV40 large T antigen expression by immunostaining with a high

110 t a novel monoclonal antibody detected MCPyV large T antigen expression in 56 of 58 (97%) unique MCC

111 By immunohistochemistry, SV40 large T antigen expression in the prostate epithelium wa

112 the percentage of BKV infected cells and the large T-antigen expression were significantly decreased

113 d with BKV by immunofluorescent analysis and large T-antigen expression which suggested BKV infection

114 These mutant large T antigens fail to inhibit CREB-mediated transacti

115 otransfected COS-1 cells (that provide viral large T antigen for DNA replication) to examine the effe

116 that the deletion of the C terminus of MCPyV large T antigen found in MCC serves not only to disrupt

117 w that the BKPyV large T antigen, as well as large T antigens from related polyomaviruses, is alone c

118 ransgenic mice expressing viral oncoprotein (large T-antigen from human polyomavirus JC) became much

119 that could detect a conserved region in the large T antigen gene of BKV, JC virus (JCV), and simian

120 The vector harbors the SV40 ori and large T antigen gene, allowing portability between prima

121 , the major capsid protein gene VP1, and the large T antigen gene.

122 amino acid reading frame of opposing-strand large T antigen gene.

123 significant variation is also present in the large T-antigen gene, wherein polymorphisms are found in

124 oint mutations were detected in both VP1 and large T antigen genes.

125 tissues harbor a temperature-sensitive SV40 large T antigen (H-2K(b)-tsA58 mice; ImmortoMice).

126 ssay was related to their inhibition of SV40 large T antigen helicase activity.

127 and atomic switch exist between PspF and the large T antigen helicase, suggesting conservation in the

128 d residue pairs, R498/D499 and R540/D502, in large-T-antigen helicase are critically involved in the

129 solution structural data for simian virus 40 large-T-antigen helicase revealed a set of nine residues

130 the hexameric bacteriophage T7 gp4 and SV40 large T-antigen helicases, that a great structural and m

131 , a loxP-flanked stop cassette, and the SV40 large T-antigen (iAST).

132 ances the DNA damage G2/M checkpoint in SV40 large T antigen immortalized murine embryonic fibroblast

133 tumorigenic, metastatic subline of the SV40 large T-antigen immortalized human prostate epithelial s

134 PTB is also overexpressed in SV40 large T-antigen immortalized ovarian epithelial cells co

135 es and in a rat dopaminergic cell line - the large T-antigen immortalized, mesencephalon-derived 1RB3

136 ot S) arrest response was diminished in SV40 large T antigen-immortalized embryonic fibroblast cells

137 ntly enhanced the tumorigenic effect of SV40 large T antigen in airway epithelium.

138 Transgenic mice expressing simian virus 40 large T antigen in enterocytes develop intestinal hyperp

139 eting Bub1 by RNAi or simian virus 40 (SV40) large T antigen in normal human diploid fibroblasts resu

140 was more effective than full-length and 57kT large T antigen in promoting the growth of human and mou

141 Thus, like the large T antigen in SV40 replication, Cdc45p plays a cent

142 lar differentiation can be inhibited by SV40 large T antigen in the absence of pRb inactivation, and

143 High level expression of BKV large T antigen in the primary and metastatic carcinoma,

144 aborating with hTERT and the simian virus 40 large T antigen in the transformation of primary human k

145 ent, we used transgenic mice expressing SV40 large T antigen in their prostatic neuroendocrine cells,

146 rus large T antigen in vivo, PCAF acetylates large T antigen in vitro, and large T-antigen acetylatio

147 PCAF and GCN5 interact with polyomavirus large T antigen in vivo, PCAF acetylates large T antigen

148 s the antibody unsuitable for studies of BKV large T-antigen in the human cells.

149 these cell lines with the expression of SV40 large T antigen increased the levels of Ras activation a

150 to mimic the introduction of simian virus 40 large T antigen, indicating that large T antigen may tar

151 In control mice, the onset of C3(1)/SV40-large T-antigen-induced mammary tumors occurred at 21.6

152 In contrast, expression of simian virus 40 large T antigen induces sustained cardiomyocyte prolifer

153 erature of 34 degrees C, these cells express large T antigen, inducing their continuous proliferation

154 To test whether SV40 large T antigen inhibits cellular differentiation in viv

155 Py large T antigen interacts with mSin3B, suggesting an HDA

156 Simian virus 40 large T antigen is a multifunctional oncoprotein that is

157 The SV40 large T antigen is a nuclear protein that, by itself, al

158 transgenic mice in which expression of SV40 large T antigen is driven by UPK II promoter.

159 Although SV40 large T antigen is essential, it is not sufficient for c

160 SV40 large T antigen is known to inactivate cellular proteins

161 Py large T antigen is known to interact only with pRb and p

162 The J domain of simian virus 40 (SV40) large T antigen is required for efficient DNA replicatio

163 Results reveal that the SV40 large T antigen is required for RAX-mediated, synergisti

164 We noted that Klinghoffer et al. used SV40 large T antigen (largeT) to facilitate derivation of cel

165 specific long probasin promoter and the SV40 large T antigen (LPB-Tag mice) that develop extensive HG

166 In the large probasin promoter directed SV40-large T-antigen (LPB-Tag) expressing mouse prostate, mPI

167 lar pathways through the actions of the SV40 large T antigen (LT) and the SV40 small t antigen (ST).

168 binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53.

169 sly demonstrated that simian virus 40 (SV40) large T antigen (LT) binds to the Bub1 kinase, a key reg

170 Simian virus 40 (SV40) large T antigen (LT) can immortalize and transform many

171 Polyomavirus large T antigen (LT) has a direct role in viral replicat

172 and depended on the coexpression of the SV40 large T antigen (LT) in the cells.

173 Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that i

174 The ability of polyomavirus large T antigen (LT) to promote cell cycling, to immorta

175 Simian virus 40 (SV40) large T antigen (LT), for example, targets p53 directly,

176 DNA binding and helicase domains of the MCV large T antigen (LT), suggesting a selective pressure to

177 from the highly oncogenic activities of the large T antigen (LT), which corrupts the cellular checkp

178 ly that expression of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is suffici

179 TR-mediated DDR pathways accumulate in MCPyV large T antigen (LT)-positive nuclear foci in cells infe

180 rigenesis in mice expressing simian virus 40 large T antigen (LT).

181 small t-antigen (ST) collaborates with SV40 large T-antigen (LT) and activated rasv12 to promote tra

182 report the co-crystal structure of the SV40 Large-T Antigen (LT) hexameric helicase bound to its ori

183 we have used the individual SV40 oncogenes (large T antigen [LT] and small t antigen [st]) and human

184 nt apparent affinities estimated as 1:7:100 (large T antigen [lT]:middle T antigen [mT]:sT).

185 antigens, pharmacologic interference of the large T antigen (LTA) may represent an effective therape

186 Phylogenetic trees based on large T-antigen (LTA) allow separation of subtype I into

187 or the known viral oncogene simian virus 40 large T antigen (LTAg).

188 Simian Virus 40 depends on the activities of large T-antigen (LTag), which interacts with several cel

189 on of a variety of genes, including the SV40 large T antigen, mammalian muscle-specific genes, and hu

190 an virus 40 large T antigen, indicating that large T antigen may target additional cellular functions

191 of human wild-type p53 interaction with SV40 large T antigen, Mdm2 and a panel of tumor-derived human

192 ment for specific J-domain sequences in SV40 large-T-antigen-mediated activities.

193 gents were administered to female C3(1)/SV40 large T-antigen mice from 7 to 19 weeks of age, during w

194 gnment of NLS2(APC) with the simian virus 40 large T antigen NLS (NLS(SV40 T-ag)) revealed sequence s

195 oring IN fused to the simian virus 40 (SV40) large T antigen NLS (SV40 NLS), a codon-modified SV40 NL

196 the protein competes with the canonical SV40 large T antigen nuclear localization signal (NLS) for nu

197 e nucleus of cells by the fusion of the SV40 large T antigen nuclear localization signal sequence to

198 The simian virus 40 large T antigen nuclear localization signal was fused to

199 how that the addition of the simian virus 40 large-T-antigen nuclear localization signal (NLS) result

200 actions between p53 tumor suppressor and the large T antigen of simian virus 40 were visualized in tu

201 culture and a cell line transformed with the large T antigen of simian virus 40, were developed, and

202 Large T antigen of SV40 interacts with p53, pRb/p107/p13

203 As in other polyomaviruses, the large T-antigen of MCV recognizes the viral origin of re

204 ation parallel those of the oncoprotein, the large T-antigen of the SV40 virus.

205 e rat insulin promoter II gene linked to the large-T antigen of SV40 (RIPTag) develop solid beta-cell

206 ccurred in cells immortalized by either SV40 large T antigen or p53-null mutation, whereas alpha3beta

207 ecific promoters to drive expression of SV40 large T antigen or tissue-specific oncogenes; deletion o

208 3 activity because of the expression of SV40 large T-antigen or because of a mutation in the TP53 gen

209 t that two highly constrained regions of the large T antigen ORF provided a start codon and C-termina

210 here the 2.9 A crystal structure of the MCV large T-antigen origin binding domain (OBD) in complex w

211 Here, we report the detailed large T antigen-p68 interface, as revealed in a co-cryst

212 n helicase domains of simian virus 40 (SV40) large T antigen play a critical role in DNA replication.

213 vasive motility of cells transformed by SV40 large T antigen plus activated ras.

214 ds the prototypical NLS from simian virus 40 large T-antigen preferentially at the major NLS binding

215 the J-domain function of the simian virus 40 large T-antigen protein.

216 ymorphisms were detected in the VP1, VP2 and Large T Antigen proteins, suggesting potential functiona

217 The complete Py early region encoding the large T-antigen (PyLT), middle T-antigen (PyMT) and smal

218 However, MEFs transformed by SV40 large T antigen+Ras were also resistant to apoptosis by

219 respectively, due to large deletions in the large T antigen region.

220 Addition of a heterologous NLS from SV40 large T antigen restored both nuclear targeting of Cdk2/

221 he translocation strand, suggesting that the large T antigen ring can open to bypass bulky adducts.

222 These studies have firmly established that large T antigen's inhibition of the p53 and Rb-family of

223 We propose that SV40 large T antigen's interaction with the MRE11-NBS1-RAD50

224 readily amplified contained detectable SV40 large T antigen sequences.

225 hese individuals were also negative for SV40 large T antigen sequences.

226 Sequences encoding large T antigen, small t antigen, agnoprotein, and the v

227 th the catalytic domain of human telomerase, large T antigen, small T antigen, and an oncogenic allel

228 Fabpi-TAg mice expressing large T-antigen solely in villi had ectopic enterocyte p

229 es of mtMCM are reminiscent of those of SV40 large T antigen, suggesting that the dHex form of mtMCM

230 sts, whereas immortalization induced by SV40 large T antigen supported fibroblast proliferation in th

231 ry transforming functions of simian virus 40 large T antigen (SV40 LT) are conferred primarily throug

232 umor results from ectopic expression of SV40 Large T-Antigen (SV40 T-Ag) oncogene in lens of transgen

233 Simian virus 40 (SV40) large T antigen (SVT) interferes with normal cell regula

234 Simian virus 40 (SV40) large T antigen (T Ag) interacts with the tumor suppress

235 Simian virus 40 large T antigen (T Ag) is capable of immortalizing and t

236 reports have documented the presence of SV40 large T antigen (T ag) sequences in a number of human tu

237 The simian virus 40 large T antigen (T antigen) inactivates tumor suppressor

238 es played by the SV40-encoded 708 amino-acid large T antigen (T antigen), and 174 amino acid small T

239 The simian virus 40 (SV40) oncoprotein, large T antigen (T), also interacts with Nbs1, and T-con

240 the viral oncoprotein simian virus 40 (SV40) large T antigen (T-Ag) as a transgene provide useful mod

241 In addition, the C terminus of the large T antigen (T-Ag) shows greater variability in PML

242 e shown that the combined expression of SV40 large T antigen (T-Ag), hTERT, and H-Ras is able to tran

243 ication requires only one viral protein, the Large T antigen (T-ag), which acts as both an initiator

244 A 193-kDa SV40 large T antigen (T-Ag)-binding protein, designated p193,

245 nteraction with JCV early regulatory protein large T antigen (T-Ag).

246 a Pax6 promoter to target expression of SV40 large T-antigen (T-Ag) in the undifferentiated murine em

247 Large T-antigen (T-ag) is a viral helicase required for

248 nding domain (OBD) of simian virus 40 (SV40) large T-antigen (T-Ag) is essential for many of T-Ag's i

249 The large T-antigen (T-Ag) of the human neurotropic JC virus

250 oms crystal structure of the simian virus 40 large T-antigen (T-ag) origin-binding domain (obd) repor

251 of a prototypical replicative helicase, SV40 large T-antigen (T-ag), was investigated.

252 SV40 large T antigen (TAg(Wt)) or a mutant derivative (TAg(K1

253 n tumor suppressor p53 (fused to Gal4BD) and large T antigen (TAg) (fused to VP16) was visualized in

254 either the input virus nor the expression of large T antigen (TAg) alone is sufficient to trigger the

255 ngly activated by the human polyomavirus BKV large T antigen (TAg) and adenovirus E1a.

256 estinal epithelial cells expressing the SV40 large T antigen (TAg) contain significantly lower levels

257 Simian virus 40 large T antigen (TAg) contributes to cell transformation

258 ansgenic mice expressing the simian virus 40 large T antigen (TAg) in enterocytes develop intestinal

259 n-2 gene (Defcr2) to express simian virus 40 large T antigen (TAg) in prostatic NE cells.

260 developed that expressed the simian virus 40 large T antigen (TAg) in urothelial cells under the cont

261 d that wild-type (WT) simian virus 40 (SV40) large T antigen (TAg) inhibits apoptosis via the activat

262 Simian virus 40 large T antigen (TAg) is a viral oncoprotein that can pr

263 nteractions between p53 tumor suppressor and large T antigen (TAg) of SV40 virus in a tetracycline-in

264 At least three domains of simian virus 40 large T antigen (TAg) participate in cellular transforma

265 c large probasin promoter linked to the SV40-large T antigen (Tag) that develop prostatic neoplasia h

266 Simian virus 40 large T antigen (TAg) transforms cells in culture and in

267 ically induced Dnmt1 transcription following large T antigen (TAg) translation and E2F activation.

268 transgenic mice (CC-10 TAg) express the SV40 large T antigen (TAg) under the Clara cell promoter, dev

269 virus 40 (SV40) early region, in particular, large T antigen (Tag), and the adenovirus oncoprotein E1

270 te proliferation and tumorigenesis in a SV40 large T antigen (Tag)-driven mouse model of pancreatic i

271 rus-induced activation of the oncogenic SV40 large T antigen (TAg).

272 to drive the expression of a simian virus 40 large T-antigen (TAg) gene flanked by sites for recombin

273 gene frequencies, with the presence of SV40 large T-antigen (Tag) sequences, histological subtype, a

274 ccessfully target the expression of the SV40 large T-antigen (Tag) to the epithelium of both the mamm

275 s mutant or because cells expressed the SV40 large T antigen that blocks p53 function.

276 utations result in expression of a truncated large T antigen that retains the Rb binding or LXCXE mot

277 transformation assay that also includes SV40 large T antigen, the catalytic subunit of cellular telom

278 By contrast, large T antigen, the replicative DNA helicase of the sim

279 ntroduction of three genes encoding the SV40 large-T antigen, the telomerase catalytic subunit, and a

280 ed the single-stranded DNA binding domain of large T antigen to amino acid residues 259 to 627.

281 prostate (TRAMP) model of PCa that uses SV40 large T antigen to induce PCa, loss of Foxm1 decreased t

282 on stimulation occurs through recruitment of large T antigen to the origin and acetylation by PCAF or

283 ith a defined oncogenic driver antigen (SV40 large T-antigen) to follow the activation and differenti

284 the ability of p130 to bind to E2F-4 or SV40 Large T antigen, to induce growth arrest in Saos-2 cells

285 8 (parental) and WI-38-VA13 (simian virus 40 large T antigen transformed) cell pair, GM-CSF was shown

286 ound 1 selectively induces apoptosis of SV40 large T-antigen transformed cells and significantly redu

287 ession of the highly transforming C3(1)/SV40 large T-antigen transgene, this transgenic model can be

288 MATERIALS AND C3(1) Sv-40 large T antigen transgenic mice (n = 23) were studied wi

289 DCs) and T lymphocytes,was evaluated in SV40 large T-antigen transgenic mice that develop bilateral m

290 and (b) by crossing LID mice with C3(1)/SV40 large T-antigen transgenic mice.

291 the first 127 amino acids of simian virus 40 large T antigen, under the control of the rat elastase-1

292 Unexpectedly, large T antigen unwinds DNA past a DNA-protein crosslink

293 dress these controversies, we detected MCPyV large T antigen using immunohistochemistry with two dist

294 While large T antigen was expressed to higher levels in adar1(

295 Furthermore, MCPyV-truncated large T antigen was more effective than full-length and

296 ll lines previously reported to contain SV40 large T antigen were negative for detection of the viral

297 of gold nanoparticles modified with the SV40 large T antigen were quantified using inductively couple

298 ed ovarian cystadenoma cells expressing SV40 large T-antigen, which allows bypassing of M1, develop a

299 he viral oncoprotein, simian virus 40 (SV40) large T-antigen, which is frequently used to immortalize

300 of pRb inactivation, and that interaction of large T antigen with CBP/p300 may be enhanced by a mutat