ライフサイエンスコーパス: large molecule

1 formational, discontinuous epitope on a very large molecule.

2 arily regulates the outward P2X7R current of large molecules.

3 raction speed and in their inability to load large molecules.

4 ydrophobicity of protein molecules and other large molecules.

5 used to enhance the ionization efficiency of large molecules.

6 hat hinder desorption/ionization by trapping large molecules.

7 sistance and increased flux of small but not large molecules.

8 nsitivity and signal stability for small and large molecules.

9 rophoresis and has comparable resolution for large molecules.

10 pulmonary microvascular barrier function to large molecules.

11 e to a membrane pore allowing the passage of large molecules.

12 pletion increased epithelial permeability to large molecules.

13 e selective uptake or exclusion of small and large molecules.

14 tent of cytoplasmic membrane permeability to large molecules.

15 terms of speed and memory, particularly for large molecules.

16 ltered, and the nucleus becomes permeable to large molecules.

17 that require fast mass transfer or deal with large molecules.

18 accessible to small apatite crystals but not large molecules.

19 escribed for calculating the total energy of large molecules.

20 gulates the inward permeability of P2X7Rs to large molecules.

21 litate rather than hinder diffusion even for large molecules.

22 ne accessibility mutagenesis, the relatively large molecule [2-(trimethylammonium)] methanethiosulfon

23 Vesicular transport enables the export of large molecules across the cell wall, and vesicles conta

24 t of fluid, solutes, hormones, and small and large molecules across the microvascular endothelium.

25 ifferences control the movement of fluid and large molecules across the microvascular wall of normal

26 otein family that facilitates the passage of large molecules across the periplasm.

27 rstanding of the dissociation mechanisms for large molecules adsorbed on surfaces is still a challeng

28 normalization of microvascular integrity to large molecules after 24 h.

29 reated kidney value) clearance of small- and large-molecule agents and the urine flow rates that resu

30 o a constantly changing mixture of small and large molecules, along with an abundance of bacteria, vi

31 lar components are necessary for adhesion: a large molecule and a small (9 kD) protein.

32 ave a 6-fold higher sensitivity in detecting large molecules and a 33% improvement in detecting small

33 ons as a selectivity filter for transport of large molecules and a sieve-like filter for diffusion of

34 utilization of maximal quantum coherence in large molecules and biopolymers.

35 neurofilaments was detected by exclusion of large molecules and by direct force measurements with at

36 cular beds regulate the passage of small and large molecules and cells.

37 rogen, water, and metals and the presence of large molecules and grains.

38 escriptions of mobility within structures of large molecules and membranes as well as in free space.

39 ectron dynamics and ionisation mechanisms of large molecules and nanoparticles.

40 solution-phase approach to the formation of large molecules and nanostructures by coupling reactions

41 water, the controlled covalent synthesis of large molecules and structures in vivo has remained chal

42 tside the TDA limits such as the analysis of large molecules and the use of high flow-rates.

43 ol levels, capability of analyzing small and large molecules, and good spatial resolution (250 mum).

44 ll-cell channels are permeable to relatively large molecules, and it was thought that opening of hemi

45 These NPs themselves can be considered as large molecules, and thus, applying a wet-chemical depro

46 key role in terminating the burst release of large molecules, and to provide a means for novel aqueou

47 has revolutionized the manner by which many large molecules are characterized, the highly variable a

48 cromolecules, spurring investigations of how large molecules are distributed within the crystals with

49 Large molecules are less effective at crowding than wate

50 approaches, especially when medium-sized and large molecules are modeled.

51 ethod is especially superior for cases where large molecules are sedimented at faster rotor speeds, d

52 Two fundamental problems for such large molecules are their poor penetration into tissues

53 erred between coupled heteronuclear spins in large molecules at high magnetic fields in the presence

54 s describe vibrational dephasing dynamics in large molecules at intermediate times because of the loc

55 ation and dissociation of bonds between very large molecules at rates that change considerably under

56 is directly linked to permeation of ions and large molecules (ATP and fluorescent dyes) and occurs du

57 demonstrate a novel separation mechanism for large molecules based on their radial migration in capil

58 o reconcile the small nature of DOM with the large-molecule behavior observed in other studies.

59 te is to selectively restrict the passage of large molecules between cells while allowing electrical

60 ompound classes such as macrocycles or other large molecules beyond the rule-of-five limit.

61 Moreover, like other large molecules, bscAbs may be restricted from entry int

62 digests tissue HA and facilitates spread of large molecules but is not sufficient to cause subcutane

63 of P2X7R outward and inward permeability to large molecules by Cl-(o) and Na+(o), respectively, may

64 Na+ (Na+(o)) regulates the inward current of large molecules by P2X7Rs.

65 a of the slowly diffusing species (generally large molecules) by diffusion editing, the slowly relaxi

66 Surprisingly, such heavy and large molecules can be deposited on any substrate by thi

67 Today, very large molecules can be manipulated at will, with the res

68 Individual large molecules can be positioned on surfaces, and atoms

69 on protein and shown that, in resting cells, large molecules can rapidly diffuse across the cell with

70 mers) because the degradation mechanisms for large molecules can result in hundreds of thousands to e

71 method for transporting colloidal particles, large molecules, cells, and other materials across surfa

72 ant polymer is beta-(1,6)-glucans, which are large molecules composed of a linear beta-(1,6)-glucan c

73 However, for large molecules, distant constraints might affect reacti

74 ped as new drugs for the brain because these large molecule drugs do not cross the brain capillary wa

75 e made it possible to quantify expression of large molecules during embryogenesis, little information

76 rt decreases with increasing molecular size, large molecules (e.g., albumin) are nevertheless removed

77 between the separated channels but prevents large molecules, e.g., DNA, from traversing the membrane

78 type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, op

79 Without fluid or in large molecule fluids (e.g., isopropanol, ethanol, or fl

80 to prevent the migration of cells and other large molecules from the blood into the CNS.

81 ding of fluorescein-labeled Ficoll and other large molecules from the SE/CC complex showed an irregul

82 It is a common knowledge that large molecules have small diffusion coefficients.

83 ' cage, making their replacement by a single large molecule (here adamantane or ferrocene) entropical

84 molecule guests are completely surrounded by large molecule hosts.

85 opportunities for probing atomic motion in a large molecule in a typical pump-probe measurement.

86 We have prepared a large molecule in which four perylene-3,4:9,10-tetracarb

87 The multiple charging of large molecules in electrospray ionization provides key

88 TNF increased paracellular flux of large molecules in occludin-sufficient, but not occludin

89 zation of adhered brain endothelial cells to large molecules in response to applied pulsed electric f

90 s a new approach for ionizing both small and large molecules in solids or liquid solvents with high s

91 If proteins or other large molecules in the sample bind the fluorescent probe

92 eening method for examining the diffusion of large molecules in tissues, and for studying the effects

93 picomolar range were obtained for small- and large-molecule interactions in both synthetic and cell-d

94 ion is obtained by mathematically breaking a large molecule into smaller parts, called kernels.

95 e delivery of neurotrophic factors and other large molecules into the brain.

96 Given the potential to deliver large molecules into the CNS via this technique, we prop

97 s found in nonribosomal peptide synthetases, large molecule mass spectrometry is shown to be a new, u

98 d current and an increase in permeability to large molecules, mediated by the opening of pannexin-1 h

99 at the interface between small molecule and large molecule medicinal chemistry.

100 cell-to-cell communication, via transfer of large molecules, occurs between the cell bodies of injur

101 compact form that allows comparatively very large molecules of DNA to fit inside the cell's nucleus.

102 nt investigations in animal models show that large molecules of neurotherapeutic potential can be con

103 However, the unexpected adsorption of large molecules on ZIF-8 suggests the existence of struc

104 but controversy persists as to whether such large molecules pass directly through the open ion chann

105 Evans blue was used to examine large molecule penetration into the rat TG.

106 trometry (HRMS) based approach for analyzing large-molecule proteins at the intact level in biologica

107 Large molecule quantitation by LC-MS/MS commonly relies

108 drug development of either small molecule or large molecule (recombinant proteins, gene medicines) ne

109 e intermediate states), and that crowding by large molecules reduces noise more efficiently than crow

110 However, they are highly hydrophobic and large molecules, regarded as difficult targets for in vi

111 sites of high resistance to the diffusion of large molecules, resulting in an REL of 76.5 kDa.

112 strate enhanced paracellular permeability to large molecules, revealing a potential role of JAM-A in

113 In contrast, large molecules show highest signal for the low-porosity

114 For large molecules, site-specific reversible inactivation o

115 These simulation results suggest that even large molecule solutes would be more easily cleared from

116 e signals generated by shape fluctuations of large molecules studied by feedback tracking microscopy.

117 Delivery of large molecules such as antisense inhibitors or mimics t

118 hannels can be a release site for relatively large molecules such as ATP and glutamate, which can ser

119 model predicts the topological seclusion of large molecules such as CD43 from the site of closest co

120 first report of a method for introduction of large molecules such as DNA into amphioxus embryos, open

121 to the device but did not prevent passage of large molecules such as IgG and IgM.

122 ely 12 angstroms) raises questions as to how large molecules such as LF and EF can move through the p

123 ng free Ca2+, with respect to the passage of large molecules such as mannitol and sucrose.

124 P2X7 receptor (P2X7R) expands to accommodate large molecules such as N-methyl-D-glucamine (NMDG+).

125 rotein-protein interactions usually involves large molecules such as peptides and macrocycles.

126 lar weight cutoff filter cartridge to remove large molecules such as proteins and lipids.

127 ges and slow sensor responses when detecting large molecules such as proteins and nucleic acids.

128 However, it is also common to observe that large molecules such as proteins and polymers often prod

129 ution, the determination of the structure of large molecules such as proteins, which is one of the mo

130 hyper-Raman intensities are now possible for large molecules such as R6G.

131 rgets, from rare atoms and molecules to very large molecules, such as a proteins, protein complexes,

132 ostulated to act as a filtration barrier for large molecules, such as albumin.

133 sma membrane channel permeable to relatively large molecules, such as ATP.

134 Large molecules, such as IgG, diffuse across sclera in a

135 However, even for large molecules, such as monoclonal antibodies, Alexa750

136 l units, such as small molecular ligands, or large molecules, such as proteins, can be positioned wit

137 A large body of work on glasses and large molecules suggests that this balancing should be i

138 previously been used to select aptamers for large-molecule targets such as proteins, lipopolysacchar

139 Large molecules that are assisted by transport factors (

140 edly enhanced tight junction permeability to large molecules that could be modeled by size-selective

141 Both the GDNF and the TNFR are large molecules that do not cross the blood-brain barrie

142 een the initiator-coated pore structures and large molecules that hinder desorption/ionization by tra

143 Glycoproteins are biologically significant large molecules that participate in numerous cellular ac

144 nt of bioengineered RNAs as a novel class of large molecule therapeutic agents.

145 d BBB-targeted procedure for the delivery of large-molecule therapeutic agents to treat neurological

146 y bed and enabled extravasation of small and large molecules through the blood-retina barrier.

147 ivity of multidimensional NMR experiments of large molecules through these methods.

148 rain barrier (BBB), which allows delivery of large molecules to brain tumors.

149 Large-molecule tracers, such as labeled antibodies, have

150 uires modification for protein secretion and large-molecule transport as well as for bacterial growth

151 For the same tumor types, diffusion of large molecules was significantly faster in CW than in D

152 Absence of large molecules was verified by atomic force microscopy

153 Similar conductances that are permeable to large molecules were activated by extreme hyperpolarizat

154 The most permeant to large molecules were gap junctions from A-type horizonta

155 face speeding up the gas-phase conversion of large molecules while lessening possible memory effects.

156 of the human PKD1 gene, polycystin, shows a large molecule with a unique arrangement of extracellula

157 Irradiation of nanoscale clusters and large molecules with intense laser pulses transforms the

158 all molecules from salivary mucins and other large molecules with only a 29% reduction of signal comp

159 rules for renal filtration, given that these large molecules (with aspect ratios ranging from 100:1 t