ライフサイエンスコーパス: large number

1 ia the regulation of expression levels for a large number (266) of cis-regulated genes, the majority

2 values (16o, mean GI50 of 3.3 nM) against a large number (93) of cancer cell lines.

3 also proliferate after SCI and accumulate in large numbers among astrocytes in the glial scar.

4 Given their large number and high transcription rate, tDNAs may be a

5 tatic breast cancer have not been studied in large numbers, despite patients with metastatic breast c

6 These pests emerged in large numbers in patient rooms, hallways, and stairwells

7 Their presence in large numbers in the superficial dermis, where Leishmani

8 lly resistant to antibiotics, are present in large numbers in tissue.

9 MSCs can be grown in large numbers in vitro, and autologous MSCs transfused i

10 structure with the proper Ni/Cu ratio and a large number of active sites on the surface of hierarchi

11 h highlights the potential for discovering a large number of additional natural riboswitch classes.

12 for answering many evolutionary problems, a large number of algorithms have been developed.

13 vealing that JMJD6 and U2AF65 co-regulated a large number of alternative splicing events.

14 Although a large number of analytical and numerical models have bee

15 he scientific and regulatory context for the large number of antidepressant trials in the late 1990s

16 Anopheline genomes led to the discovery of a large number of apparent discrepancies in assembly and a

17 ntaining full-length FLNC reads, including a large number of AS events associated with rhizome system

18 perform fractions of any given analysis, the large number of associated software/hardware dependencie

19 tween clock stability, which benefits from a large number of atoms, and accuracy, which suffers from

20 es are readily available for research with a large number of banked lines with associated patient cli

21 Citrus possess a large number of bioactive compounds mainly studied in ri

22 A large number of bioactive peptides isolated from natural

23 We profiled a large number of biocidal active ingredients (herbicides,

24 activities to the lung and co-expressed in a large number of breast tumors.

25 eening data have not been available across a large number of cancer cell lines.

26 A large number of cancer drivers have been identified thro

27 rate of these treatments has been low and a large number of cancers, including colorectal cancer rem

28 n, indicating the possibility of detecting a large number of carbonyl metabolites as well as high rep

29 Naturally occurring botulism is rare, but a large number of cases could result from unintentional or

30 The results provide an explanation for the large number of cases of meningococcal disease in immuni

31 er, the majority of these methods requires a large number of cells to begin with.

32 nds throughout the cell and is involved in a large number of cellular functions.

33 phages, which results in the modulation of a large number of cellular genes.

34 Our study involved a large number of centres and detailed protocol with compr

35 A large number of chloroplast RNAs was found to be associa

36 Higher eukaryotic genomes are bound by a large number of coding and non-coding RNAs, but approach

37 GATA3 and show that they directly regulate a large number of common genes to orchestrate stem versus

38 fractions of the genome to be sequenced in a large number of compartments.

39 nnectivity information for the analysis of a large number of compounds in complex mixtures, but stand

40 field, and as such can be expected across a large number of compounds.

41 We reviewed a large number of contemporary pregnancy-associated sponta

42 However, these spectra generally have a large number of contributions ranging from slow diffusio

43 CTC clusters with large number of CTCs were observed in 50% of patients, w

44 The large number of degrees of freedom and lack of symmetry

45 due to the mycobacterial genomes encoding a large number of dehydrogenases.

46 ial miRNA profiles with respect to C, with a large number of deregulated miRNAs shared by both neopla

47 tterns of income and access to services in a large number of developing cities, with an emphasis on a

48 alts and potentially enables assessment of a large number of different counter anions, including thos

49 on, is a highly dynamic complex displaying a large number of different enzyme activities.

50 Foods consist of a large number of different nutrients that are contained i

51 Multicellular organisms contain a large number of different sHsps, raising questions as to

52 Studies over the past decade have revealed a large number of disease-related mutations in the MEK1 ge

53 A large number of distal enhancers and proximal promoters

54 The ability to visualize directly a large number of distinct molecular species inside cells

55 ow low-barrier folding pathways that visit a large number of distinct structures.

56 We processed a large number of DNA-protein complexes retrieved from the

57 kflow for the measurement of CCS values of a large number of drug or drug-like molecules in nitrogen

58 The large number of Ebola survivors has highlighted the freq

59 Among the large number of efficient types of organocatalysts avail

60 RNAs bound to CBP in vivo include a large number of eRNAs.

61 nt positions within those genes, requiring a large number of evolutionary parameters that have to be

62 h charged and neutral systems and captures a large number of experimental observations.

63 mechanism in STKR1 kinases that reconciles a large number of experimental studies and sheds light on

64 hout multi-testing correction can generate a large number of false positives while multi-testing corr

65 zes may be more or less important and thus a large number of features extracted might end up being re

66 include machine learning methods utilizing a large number of features, including molecular informatio

67 A large number of fluorescent dyes were loaded into Alb NP

68 A large number of follicular helper T (Tfh) cells were als

69 extensive gene splicing that gives rise to a large number of functional and nonfunctional isoforms.

70 Because of the large number of genes and alleles attributed to DCM, com

71 Intriguingly, a large number of genes coding for ionotropic and metabotr

72 pairment in Down syndrome is hindered by the large number of genes duplicated in Trisomy 21 and a lac

73 The identification of a large number of genes essential for serum resistance in

74 This screen also yielded a large number of genes expressed in a lamina-specific man

75 MIA strongly upregulates expression of a large number of genes involved in translation initiation

76 iles in rhd6, modulating the expression of a large number of genes related to cell wall composition a

77 n dynamically regulating the expression of a large number of genes upon temperature shifts.

78 ficiency of CUX1 altered the expression of a large number of genes, including cell cycle regulators,

79 SFPS regulates pre-mRNA splicing of a large number of genes, of which many are involved in reg

80 p towards developing "activator drugs" for a large number of genetic disorders where mutations have d

81 sequencing (NGS) technique have identified a large number of genetic variants including copy number (

82 Here we identified a large number of genetic variants that are associated wit

83 effect is rather complex, attributable to a large number of genetic variants, and many variants func

84 ded the discovery of the genetic basis for a large number of genodermatoses and continue to provide a

85 Reconstructing and analyzing a large number of genome-scale metabolic models is a funda

86 We identified a large number of genomic elements that superficially reas

87 Such draft genomes consist of a large number of genomic fragments (scaffolds), whose pos

88 genome scale loss-of-function screening in a large number of genomically annotated cancer cell lines.

89 During spermatogenesis, a large number of germline genes essential for male fertil

90 However, the large number of GLR genes present in angiosperm genomes

91 istical framework, graph-GPA, to integrate a large number of GWAS datasets for multiple phenotypes us

92 reducing assay complexity and leveraging the large number of hemagglutinin proteins on the surface of

93 Over the past two decades, a large number of highly diverse systems have been studied

94 tile area of research due to the significant large number of host and viral products that regulate th

95 Furthermore, by analyzing a large number of human antibody sequences and structures,

96 ine methyltransferases are associated with a large number of human diseases, including cancer.

97 By analyzing imputed data for a large number of human traits, we empirically derive a mo

98 ypothesis of schizophrenia is supported by a large number of imaging studies that have identified an

99 Despite the large number of imine bonds formed, the corresponding ca

100 Photochemical reactions are essential to a large number of important industrial and biological proc

101 to treat infections, there continue to be a large number of inappropriately prescribed antibiotics.

102 recent genome sequencing projects revealed a large number of indels in various cancer types.

103 mplaints, and depression) was predicted by a large number of indicators of working conditions in both

104 o principles that can be used to influence a large number of individuals to participate in such activ

105 eeping patterns using mobile phone data of a large number of individuals.

106 s review that meta-analyses that include the large number of industry-sponsored antidepressant trials

107 y mapped the response of CD4(+) T cells to a large number of input cytokine combinations that drive t

108 lectron microscopy (TEM), we observed that a large number of intact IBDV virions were arranged in a l

109 vely simple to implement even for medium and large number of interactive particles, and uses tools an

110 ch a single neuronal stem cell can produce a large number of interneurons with similar functional cap

111 rbons were positively identified including a large number of isomeric compounds, both aliphatics and

112 In general, CIIIPRX genes encode a large number of isozymes with ranges of in vitro substra

113 The large number of L. pneumophila effectors has been a limi

114 deep probabilistic graphical models requires large number of labeled training samples, we propose to

115 CR has demonstrable reproducibility across a large number of laboratories without calibration.

116 We identify a large number of layer-specific accessible sites, and sig

117 fly lines that can be used directly with the large number of LexA driver lines with known expression

118 n studies of tumor samples have identified a large number of lncRNAs associated with various types of

119 We describe an approach, sampling a large number of loci across the genome from functional c

120 To date, a large number of long non-coding RNAs (lncRNAs) have been

121 pid leukemic proliferation when there were a large number of LSCs, while a small number of LSCs requi

122 ub sensory neuron/interneuron, integrating a large number of male-specific synaptic inputs and convey

123 ce receiving intraperitoneal saline stored a large number of mature granulocytes expressing a high le

124 A large number of MDD patients do not respond to the curre

125 The large number of measured loci facilitates whole genome m

126 how that for complex samples there will be a large number of metabolites where traditional DDA approa

127 a major nAChR-binding mechanism shared by a large number of MG antibodies and the possibility to tre

128 ing have led to whole-genome sequences for a large number of microorganisms, enabling the application

129 A large number of miR-122 targets were found to be species

130 However, the large number of miRNAs and their targets mean that a com

131 While a large number of miRNAs have already been annotated, ther

132 tude of marine organisms and were used for a large number of molecular machines.

133 ing disease correlated features early before large number of molecules are impacted by disease progre

134 s were not particularly noteworthy given the large number of more strongly associated noncandidate ge

135 cted a few important miRNAs that regulated a large number of mRNAs in the control group but not in th

136 ophic event, such as chromothripsis, where a large number of mutations instead occur simultaneously.

137 nd anterior cingulate cortex (ACA) contain a large number of neurons activated during PS hypersomnia.

138 critical for learning and memory, contains a large number of neurons that develop in the early postna

139 implications for stress surveillance by the large number of NKG2D-expressing NK cells sequestered in

140 CLAM recovered a large number of novel RNA regulatory sites inaccessible

141 This is a potential concern if the large number of older scientists crowds out younger scie

142 stic signatures, suggesting that including a large number of omic biomarkers may provide substantial

143 s good potential to determine of pungency in large number of onions in a short time using minimal amo

144 A large number of organic contaminants are commonly found

145 icted protein-protein association data for a large number of organisms.

146 ent study of transport and diamagnetism in a large number of overdoped La2-xSrxCuO4 (LSCO) films show

147 Our Wide-Open system identified a large number of overdue datasets, which spurred administ

148 The discovery of a large number of p53 target genes, which confer p53's tum

149 Although a large number of PAINS have been classified, often on the

150 In particular a very large number of pairwise associations can arise indirect

151 Within only two synaptic layers, a large number of parallel information channels emerge, ea

152 Given the large number of parameters in most models, this is no tr

153 transition kernel to estimate in parallel a large number of parameters, split across partitioned dat

154 screens prohibits experimental testing of a large number of parameters.

155 This modification is mediated by a large number of parasite proteins that are exported to t

156 eloped methods to manage and consolidate the large number of partial results that get produced.

157 ks by spreading the target material across a large number of partitions.

158 o, in HIV disease progression by analyzing a large number of patients in 3 cohorts with different HIV

159 ria transmission globally in recent years, a large number of people remain at risk and hence the gain

160 A large number of peptides are generated during the proces

161 a unique mode of propagation and, given the large number of polarly flagellated bacteria, we expect

162 alysis to check the purity with respect to a large number of possible contaminant elements.

163 nt approaches to the exploration of both the large number of possible elemental compositions for such

164 ions are of limited applicability due to the large number of possible isomeric forms, for example, mo

165 ing a sparse model, where only a subset of a large number of possible predictors is used, and trainin

166 res (computerized algorithm used to select a large number of potential confounders) and by comparing

167 represent a cell-cell interaction hub with a large number of potential incoming and outgoing signals.

168 ly symmetrical cavitands are sorted out of a large number of potentially feasible products, which rep

169 rst committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivat

170 s when such values exist, and they provide a large number of previously unavailable values.

171 Collagen contains a large number of proline residues, so the cis/trans isome

172 lar quantification analyses, we identified a large number of prominent cell groups expressing high le

173 The comparably large number of proteinaceous pectin methylesterase inhi

174 Here, we show that MKK3 interacts with a large number of proteins critical for cell growth and me

175 Given the large number of proteins needed for synaptic function, t

176 ometry on the cellular sheddings show that a large number of proteins, both membrane and intracellula

177 In recent years, a large number of publications has appeared on photoregula

178 There are a large number of published studies with deposited dataset

179 ow that nanopores can absorb and eliminate a large number of radiation-induced defect clusters.

180 e feasible flux space allowed us to obtain a large number of randomly mutated cells simulated at diff

181 Our data suggest that the use of a large number of rapidly evolving species-specific protei

182 ity level of 80%, supporting the view that a large number of rare and minute marine species may have

183 acterization of functional phenomena using a large number of related phenotype measures, which can be

184 stigation of the biological variability on a large number of samples in a time and cost efficient man

185 n of the data remains intractable due to the large number of samples in the archive.

186 ones with CRISPR-mediated genomic edits in a large number of samples is made possible by next generat

187 Analysis of a large number of samples requires an efficient, rapid and

188 he method is time-consuming when analyzing a large number of samples.

189 nges on the ability to make initially a very large number of separate analyses, allowing each explana

190 Using a large number of sequencing datasets, we demonstrate how

191 growth through a cumulative inhibition of a large number of Ser- and Cys-containing enzymes particip

192 ze HHV-8 transmission, and households with a large number of siblings should receive additional couns

193 ntegrated microfluidic platform to analyze a large number of single cells in parallel.

194 By recording simultaneously from a large number of single neurons in alert mice viewing mov

195 sites, we first predict the CO binding at a large number of sites and select four exhibiting CO bind

196 sity functional theory calculations reveal a large number of sites at the interface between the Co an

197 population change of 15% or less requires a large number of sites to be surveyed, which might be una

198 ts with anti-SRP(+) and anti-HMGCR(+) Abs, a large number of small fibers corresponding to both atrop

199 ep of bioinformatics analyses, revealing the large number of steps devoted to the pre-processing of d

200 rentiating epidermal keratinocytes express a large number of structural and antimicrobial proteins th

201 understand this complex material we bring a large number of structural and magnetic techniques to be

202 Given their low concentrations and large number of structurally similar components, mass sp

203 human sarcoma cell line availability and the large number of STS subtypes, making development of STS

204 hyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of >/=10%.

205 We found that KRCV-1 quickly acquired a large number of substitutions in its genome during repli

206 sickle (SS) red blood cells (RBCs) express a large number of surface receptors that mediate cell adhe

207 (RNA) potentially present in the semen of a large number of survivors of Ebola virus disease (EVD) i

208 groups: species with the ability to harbour large number of symbionts, Orbicella annularis and O. fa

209 Icosahedral viral capsids are made of a large number of symmetrically organized protein subunits

210 using on the center of this area, we found a large number of taste responsive cells ranging from narr

211 ly available plastomes and can accommodate a large number of taxa.

212 xpression of ID1, it induced expression of a large number of terminal differentiation genes.

213 he context of plant cell division in which a large number of TGN-derived membrane vesicles fuse with

214 The large number of these functional protein binding correla

215 ed through aliovalent doping, to introduce a large number of titanium vacancies that act as intercala

216 To achieve accurate results in practice, a large number of trainable parameters are often required.

217 nal regulation in vivo because it involves a large number of transcripts that are physically sequeste

218 of the TRN and the dLGN, we reconstructed a large number of TRN neurons that were retrogradely label

219 tensin receptor 1 (NTR1) has been shown in a large number of tumor entities such as pancreatic or col

220 k permits and freedom from deportation for a large number of undocumented immigrants.

221 uctures by noncovalent forces has provided a large number of unprecedented supramolecular assemblies

222 escales of neurotransmission, exploiting the large number of v-SNAREs available in synaptic vesicles.

223 t correlations across abundant datasets with large number of variables.

224 al neural network models and apply them to a large number of varied existing biomedical named entity

225 Strikingly, we resolve a large number of very high quality (Q approximately 1 x 1

226 actionated viral metagenomic data generate a large number of viral contigs with missing host informat

227 The large number of Wnts, Frizzleds, and SFRPs, as well as t

228 Bats host a large number of zoonotic viruses, including several viru

229 ive biomaterial platform to rapidly generate large numbers of action-potential firing mDA neurons aft

230 Interestingly, despite the presence of large numbers of adult and first-stage larvae in S. ster

231 apable of selectively and efficiently fusing large numbers of aromatic rings, yet such methods remain

232 ntered the lesions over the next 7 d, as did large numbers of axons that were not present in controls

233 g basic developmental principles to generate large numbers of bonafide hair cells in vitro.

234 vation and automated longitudinal imaging of large numbers of C. elegans confined to individual wells

235 degrading insoluble polysaccharides possess large numbers of carbohydrate active enzymes (CAZymes),

236 the submucosa where they are in contact with large numbers of CD4(+) Th cells.

237 These approaches are time-consuming, require large numbers of cells and are resource intensive.

238 apies since they can be expanded to generate large numbers of cells and differentiated into presumabl

239 airways by developing a schema of isolating large numbers of cells by whole-lung bronchoalveolar lav

240 neering is predicated on the availability of large numbers of cells, in vitro cell expansion of tooth

241 say is costly, labor-intensive, and requires large numbers of cells.

242 We demonstrate that large numbers of chromaffin cells arise from peripheral

243 Sequencing the genomes of large numbers of closely related strains provides new op

244 r in most experiments is the availability of large numbers of cold ground state antihydrogen atoms.

245 Shifting large numbers of college science, technology, engineerin

246 et microfluidics relies on the generation of large numbers of compartments either for ultrahigh throu

247 unbiased comparative metabolite profiling of large numbers of complex LC-MS chromatograms remains a c

248 One approach for realizing large numbers of concurrent separations is open microflu

249 iversity Outbred (DO) mouse stock accumulate large numbers of crossover (CO) events between founder h

250 The ability to generate large numbers of devices ( approximately 36) per experim

251 id and effective high-resolution analysis of large numbers of diverse isolates, the cgMLST scheme ena

252 Studies of large numbers of early cervical lesions revealed frequen

253 he absence of tailocins and revealed instead large numbers of extracellular vesicles in settlement-in

254 Genomic sequencing has implicated large numbers of genes and de novo mutations as potentia

255 es not play a significant role in regulating large numbers of genes important for programming seed de

256 ribe a protocol for generating and expanding large numbers of homogeneous midbrain floor plate progen

257 efore about 11,200 years ago, which produced large numbers of icebergs smaller than the typical tabul

258 etic variation and trait measurements across large numbers of individuals, providing tremendous oppor

259 The main distinguishing features include (i) large numbers of isolated compartments of tiny volumes t

260 terial properties enables rapid screening of large numbers of materials and facilitates the design of

261 ve already been annotated, there may well be large numbers of miRNAs that are expressed in very parti

262 The large numbers of mitochondria in HCEnCs are critical for

263 A plasma cells by cloning and characterizing large numbers of monoclonal antibodies.

264 thods involving the rearing and releasing of large numbers of mosquitoes to eliminate or modify local

265 have been developed to assess the effects of large numbers of mutations (variation) on phenotypes.

266 wer neuromorphic computing will require very large numbers of nanoscale nonlinear oscillators.

267 Bacteria contain large numbers of negatively-charged proteins to avoid th

268 al probe should be capable of recording from large numbers of neurons across multiple local circuits

269 e present stimulus can be compensated for by large numbers of neurons.

270 nterference in real space, which may rely on large numbers of optical elements, and the requirement o

271 Analysis of two bedding surfaces preserving large numbers of Parvancorina illustrates that individua

272 infection, white adipose tissue accumulated large numbers of pathogen-specific memory T cells, inclu

273 pediatric hospitals to provide treatment to large numbers of patients during a large-scale disaster

274 graphene nanosheets can cooperate to extract large numbers of phospholipids from the membrane bilayer

275 phylococcus aureus (MRSA) is responsible for large numbers of postsurgical nosocomial infections acro

276 x traits, particularly in species that carry large numbers of rare polymorphisms.

277 or-group lineages may contribute to the very large numbers of rhinovirus serotypes that coexist while

278 f 1,225 clinical HCC samples revealed that a large numbers of RNA binding proteins (RBPs) are dysregu

279 opulation level genetic studies that require large numbers of samples such as various strains of a mi

280 can be measured reliably and genome-wide in large numbers of samples.

281 y informaticians and biologists working with large numbers of scientific names.

282 expert scientists, primarily by scrutinizing large numbers of scientific publications.

283 sturbances are moderated sufficiently and if large numbers of seed can be collected in sufficient qua

284 Delphinids produce large numbers of short duration, broadband echolocation

285 ple models of varying size, we show that for large numbers of simulations PySB/cupSODA achieves order

286 tochastic dynamic models relies on producing large numbers of simulations, but this remains a slow an

287 Large numbers of single nucleotide polymorphisms have be

288 bility (MSI), which leads to accumulation of large numbers of small insertions and deletions (indels)

289 Instead, it was characterized by large numbers of smaller icebergs with V-shaped keels.

290 Large numbers of statistically significant associations

291 Here, utilizing the large numbers of structures and functional annotations n

292 ased or large-scale clinical studies demands large numbers of subjects and therefore sample batching

293 diagnostics are urgently required given the large numbers of suspected enteric fever patients with a

294 Thus the GLIPH algorithm can analyse large numbers of TCR sequences and define TCR specificit

295 e SL3261/surf or SL3261/sec strain generated large numbers of Th1 CD4(+) ESAT-6(+) splenic T cells co

296 s complex co-regulatory mechanisms involving large numbers of transcriptional regulatory proteins and

297 sis (EOS) result in medical intervention for large numbers of uninfected infants.

298 oundly impact its pharmacology and result in large numbers of useful pharmacological tools, agents wi

299 lly, then degenerated after postnatal day 5; large numbers of vesicles invaded the compromised cuticu

300 ity-control performance, as confirmed by the large number (thousand) of conducted water vapor adsorpt