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1 in that penetrates deep into the core of the large ribosomal subunit.
2 in the details of their manipulation of the large ribosomal subunit.
3 A2058 and A749-753 in the exit tunnel of the large ribosomal subunit.
4 part of the GTPase-associated center of the large ribosomal subunit.
5 n is a universal element of the RNA from the large ribosomal subunit.
6 in late-assembly ribosomal proteins into the large ribosomal subunit.
7 ilitate essential steps in biogenesis of the large ribosomal subunit.
8 1, and RpL5 and RpL38 encode proteins of the large ribosomal subunit.
9 a methyl-accepting substrate elutes with the large ribosomal subunit.
10 the peptidyl transferase center (PTC) of the large ribosomal subunit.
11 aryotic Obg proteins are associated with the large ribosomal subunit.
12 form part of the peptide exit tunnel in the large ribosomal subunit.
13 stal structure of the Haloarcula marismortui large ribosomal subunit.
14 e likely, Mtg1p functions in assembly of the large ribosomal subunit.
15 be cross-linked to Mrp20, a component of the large ribosomal subunit.
16 ck protein synthesis by interacting with the large ribosomal subunit.
17 mature 5.8S and 28S rRNAs, components of the large ribosomal subunit.
18 led in the crystallographic structure of the large ribosomal subunit.
19 al protein synthesis by interacting with the large ribosomal subunit.
20 7/L12 dimers and thereby anchors them to the large ribosomal subunit.
21 nding of tRNA in the functional sites of the large ribosomal subunit.
22 ypeptide component of the mitochondrial 54 S large ribosomal subunit.
23 lease of the nuclear export adapter from the large ribosomal subunit.
24 ss through an exit tunnel that traverses the large ribosomal subunit.
25 ubunit in a quality control complex with the large ribosomal subunit.
26 of the P-site tRNA toward the A site of the large ribosomal subunit.
27 ion on leaderless mRNAs does not require the large ribosomal subunit.
28 BSE) that participates in recruitment of the large ribosomal subunit.
29 somal protein uL23 at the tunnel exit on the large ribosomal subunit.
30 se center, the main antibiotic target in the large ribosomal subunit.
31 enters the peptidyltransferase center of the large ribosomal subunit.
32 primarily by the binding of the drug to its large ribosomal subunit.
33 denosine at position 2503 in 23S rRNA in the large ribosomal subunit.
34 nically relevant antibiotics that target the large ribosomal subunit.
35 l proteins to the RNAs forming the small and large ribosomal subunits.
36 iated with ribosomes, predominantly with 60S large ribosomal subunits.
37 ncy causes the aggregation of both small and large ribosomal subunits.
38 inhibiting the association of the small and large ribosomal subunits.
39 subunits and also affected the stability of large ribosomal subunits.
40 undant tertiary structure interaction in the large ribosomal subunit; 186 adenines in 23S and 5S rRNA
41 mall ribosomal subunit (30S) relative to the large ribosomal subunit (50S) during translation is wide
42 wn the presence of expansion segments in the large ribosomal subunit (60S) of Trypanosoma brucei.
45 f the nascent peptide with components of the large ribosomal subunit along the path it follows betwee
46 it may change the folding or dynamics of the large ribosomal subunit, altering the rate of GTP hydrol
47 FRET between the Cy3-labeled L1 stalk of the large ribosomal subunit and a Cy5-labeled tRNA(Lys) in t
48 (RPL9 or L9), an essential component of the large ribosomal subunit and a putative tumor suppressor,
49 e orchestration of the early assembly of the large ribosomal subunit and in faithful protein producti
50 igosaccharide antibiotic, interacts with the large ribosomal subunit and inhibits bacterial protein s
51 260c as LTO1; required for biogenesis of the large ribosomal subunit and initiation of translation in
52 rgest and most variable ES of the eukaryotic large ribosomal subunit and is located at the surface of
54 al stalk structure in the active site of the large ribosomal subunit and is thought to assist in the
55 ure establishes how Ltn1 associates with the large ribosomal subunit and properly positions its E3-ca
56 S enhances tRNA binding to the P site of the large ribosomal subunit and slows down spontaneous inter
57 strates that the initial contact between the large ribosomal subunit and the Sec61 complex is importa
58 is for its involvement in recruitment of the large ribosomal subunit and the switch between viral tra
59 teracts with the central protuberance of the large ribosomal subunit and with the P site-bound tRNA t
60 ells blocks rRNA maturation and synthesis of large ribosomal subunits and induces a reversible, p53-d
61 the last decade, structures of the small and large ribosomal subunits and of the intact ribosome have
62 view of the interface between the small and large ribosomal subunits and the conformation of the pep
63 ern of rRNA degradation, particularly in the large ribosomal subunit, and accumulate rRNA fragments a
64 n all forms of life, rRNAs for the small and large ribosomal subunit are co-transcribed as a single t
65 Nearly all the bridges between the small and large ribosomal subunits are indicated by CG interaction
67 to show that this protein interacts with the large ribosomal subunit as well as with a series of non-
68 served between the factor's G domain and the large ribosomal subunit, as well as between domain IV an
69 RPL5-mutated iPSCs exhibited defective 60S (large) ribosomal subunit assembly, accumulation of 12S p
71 he efficiency of late steps in biogenesis of large ribosomal subunits at low temperatures, presumably
73 ntial GTPases YphC and YsxC are required for large ribosomal subunit biogenesis in Bacillus subtilis.
74 ifested at the biological level by affecting large ribosomal subunit biogenesis, ribosomal subunit jo
79 is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methy
80 to be fundamentally an RNA machine, and the large ribosomal subunit can carry out peptidyl transfer
84 nserved, independently folding domain in the large ribosomal subunit consists of 58 nt of rRNA and a
89 s the smallest nucleic acid component of the large ribosomal subunit, contributing to ribosomal assem
90 center in the Haloarcula marismortui (H.ma) large ribosomal subunit crystals and consequently allows
91 we evaluated the ability of CGB agar and D2 large ribosomal subunit DNA sequencing (D2 LSU) to diffe
92 ward/outward movement of the L1 stalk of the large ribosomal subunit during the subunit-joining step
93 rs all interact with the L7/L12 stalk of the large ribosomal subunit during their respective GTP-depe
96 preinitiation complex (i.e., small, but not large, ribosomal subunits, eIF3, eIF4E, eIF4G) are coord
97 mortui to anisomycin and the affinity of its large ribosomal subunits for the drug indicates that its
98 Distinct rRNA elements and proteins of the large ribosomal subunit form four connections with the P
100 We have shown that Rpl3, a protein of the large ribosomal subunit from baker's yeast (Saccharomyce
101 ve developed an affinity purification of the large ribosomal subunit from Deinococcus radiodurans tha
102 atomic resolution crystal structures for the large ribosomal subunit from Haloarcula marismortui and
104 have determined the crystal structure of the large ribosomal subunit from Haloarcula marismortui at 2
105 rystallographic electron density maps of the large ribosomal subunit from Haloarcula marismortui at v
106 he 2.4-A resolution crystal structure of the large ribosomal subunit from Haloarcula marismortui reve
107 etermined using the crystal structure of the large ribosomal subunit from Haloarcula marismortui.
109 Here we present the crystal structure of the large ribosomal subunit from Staphylococcus aureus, a ve
110 nylated tRNA substrates to randomly modified large ribosomal subunits from Escherichia coli and captu
112 tui) and bacterial (Deinococcus radiodurans) large ribosomal subunits have been reported, it remains
113 ment of the L1 stalk, a mobile domain of the large ribosomal subunit, have been shown to accompany th
114 methylcytosine RNA methyltransferase, to the large ribosomal subunit in a process crucial for mitocho
115 l inner membrane and associates with the 54S large ribosomal subunit in a salt-dependent manner.
116 tein RbgA is involved in the assembly of the large ribosomal subunit in Bacillus subtilis, and homolo
117 Ribosomal protein L14e is a component of the large ribosomal subunit in both archaea and eukaryotes.
121 herichia coli 70S ribosome, RRF binds to the large ribosomal subunit in the cleft that contains the p
124 embranes, the Sec61beta(c) sequence binds to large ribosomal subunits in preference over small subuni
125 n apparent block in the nucleolar release of large ribosomal subunits in terminally differentiated la
128 ral subgroup and was most closely related to large ribosomal subunit introns that express single-moti
130 ng ES27, and suggest a function for ES30.The large ribosomal subunit is linked to the channel by four
132 ecent study shows that nuclear export of the large ribosomal subunit is regulated by a GTPase that bl
133 Sucrose density gradient centrifugation of large ribosomal subunits isolated from YphC-depleted cel
134 ng high-resolution structures for eukaryotic large ribosomal subunits, it remained unclear how these
135 ite being abundant as a component of the 60S large ribosomal subunit, L11 does not induce p53 under n
137 has extensive identity and similarity to the large ribosomal subunit L7 proteins and shares an RNA-bi
138 sent in the high molecular mass RNA from the large ribosomal subunit (LSU) have been sequenced from r
140 the case of the N. crassa mitochondrial (mt) large ribosomal subunit (LSU) intron, it appears to act
141 the five cleavage sites of the kinetoplastid large ribosomal subunit (LSU) rRNA chain, which is known
142 domain complexed with L11 protein and of the large ribosomal subunit (LSU) suggest that this thermody
143 ofiles to other antibiotics specific for the large ribosomal subunit (macrolides and chloramphenicol)
144 studies indicate that SBDS functions in 60S large ribosomal subunit maturation and in mitotic spindl
147 We present evidence that OT may bind to the large ribosomal subunit near the site where nascent poly
148 or this loop in the crystal structure of the large ribosomal subunit of Deinococcus radiodurans.
150 Here we describe three new structures of the large ribosomal subunit of Haloarcula marismortui (Hma)
151 oharringtonine, and bruceantin form with the large ribosomal subunit of Haloarcula marismortui at res
152 sticidin S, and virginiamycin M bound to the large ribosomal subunit of Haloarcula marismortui have b
155 d polypeptide chains as they emerge from the large ribosomal subunit, or how these conformations comp
156 ed mutations in rpl-11.1 (L11 protein of the large ribosomal subunit), pab-1 [a poly(A)-binding prote
157 haploinsufficiency of Mrpl40 (mitochondrial large ribosomal subunit protein 40) as a contributor to
158 rin resistance is dependent on the essential large ribosomal subunit protein L10e in S. cerevisiae.
160 somes and can stably interact with rpL23a, a large ribosomal subunit protein present at the tunnel ex
162 In the yeast Saccharomyces cerevisiae, the large ribosomal subunit protein Rpl3p is methylated at h
163 ular stomatitis virus (VSV), we identify the large ribosomal subunit protein rpL40 as requisite for V
168 and with published data from an analysis of large ribosomal subunit proteins, both from the yeast S.
170 between assembly of bacterial and eukaryotic large ribosomal subunits, providing insights into how th
171 uctures, the interface between the small and large ribosomal subunits rearranges in discrete steps al
172 To understand the structural basis for the large ribosomal subunit recruitment and the intricate in
173 the basis of these results, we propose that large ribosomal subunit release from the ER membrane is
177 ther is predicted to modify a portion of the large ribosomal subunit RNA belonging to the peptidyltra
179 nteractions in the crystal structures of the large ribosomal subunit RNAs of Haloarcula marismortui a
183 resin, we identified four nucleotides in the large ribosomal subunit rRNA (positions G2252, A2451, U2
184 RF interacts mainly with the segments of the large ribosomal subunit's (50S) rRNA helices that are in
185 panning the D1 and D2 regions (D1/D2) of the large ribosomal subunit-showed that sequence analysis pr
186 ribosomal protein L13a is released from the large ribosomal subunit soon after infection and inhibit
187 ned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both s
188 in the direct vicinity of the A site of the large ribosomal subunit, suggesting a possible interacti
189 as a substrate, but not the fully assembled large ribosomal subunit, suggesting that the methylation
191 rotein L27 is a component of the eubacterial large ribosomal subunit that has been shown to play a cr
193 of the L1 stalk, a structural element of the large ribosomal subunit that is implicated in directing
194 ut the three-dimensional architecture of the large ribosomal subunit, the mechanism by which it facil
195 The model explains the evolution of the large ribosomal subunit, the small ribosomal subunit, tR
196 own antibiotics that affect functions of the large ribosomal subunit, these drugs act on only a few s
198 lation initiation, recruiting both small and large ribosomal subunits to viral RNA without the use of
199 quitin is ligated to L28, a component of the large ribosomal subunit, to form the most abundant ubiqu
201 gests that a defect in the biogenesis of the large ribosomal subunit underlies the ribosome deficienc
202 icles obtained by extraction of T. aquaticus large ribosomal subunits were isolated and their RNA and
203 nd in the nascent peptide exit tunnel of the large ribosomal subunit with comparable affinities, the
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