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1 is the human homolog of the Drosophila Discs-large tumor suppressor.
2 emonstrated that the HIPPO central component large tumor suppressor 1 (LATS1) is inactivated in small
3 ns showed enrichment of shRNAs targeting the large tumor suppressor 1 (LATS1) kinase that inhibits th
4 , loss of the Hippo pathway kinases LATS1/2 (large tumor suppressor 1 and 2) in tumor cells inhibits
5 m its previously described role in degrading large tumor suppressor 1 to the inhibition of YAP and ce
7 ation of their negative regulators, LATS1/2 (large tumor suppressor 1/2) kinases, to constitute a neg
8 at KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating t
9 targets included the tumor-suppressive genes large tumor suppressor 2 (LATS2) and PP2A regulatory sub
10 KIBRA also promotes the phosphorylation of large tumor suppressor 2 (Lats2) on Ser(83) by activatin
11 activation of mammalian sterile 20-like 1/2-large tumor suppressor 2 signaling pathway and inhibitio
12 man homologue (hDIg) of the Drosophila discs-large tumor suppressor (DIg) is a multidomain protein co
13 tic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), zonula occludens-1 protei
14 lymphocyte homologue of the Drosophila discs large tumor suppressor) do not bind the cytoplasmic doma
16 n genome, it represents another example of a large tumor suppressor gene, like FHIT and WWOX, located
17 of the membrane-associated Drosophila discs-large tumor suppressor has implicated this cellular fact
20 alian STE20-like protein kinases 1 and 2 and large tumor suppressor homologs 1 and 2 (LATS1/2) contro
21 inhibits the association between MST1/2 and large tumor suppressor homologs 1/2 (LATS1/2), uses its
22 ivation of Yes-associated protein (YAP) in a large tumor suppressor homologue (Lats)-dependent manner
23 an STE20-like protein kinase 1/2 (MST1/2) or large tumor suppressor kinase 1/2 (Lats1/2), two sets of
24 ian STE20-like protein kinases 1/2 (MST1/2), large tumor suppressor kinases 1/2 (LATS1/2), and Yes-as
26 Hpo increases its affinity with Warts (Wts)/large tumor suppressor (Lats) serine/threonine protein k
27 (Hpo), Salvador (Sav)/Shar-pei, Warts (Wts)/Large tumor suppressor (Lats), and Mob as tumor suppress
28 similar effect is achieved upon silencing of large tumor suppressor (LATS)-1 and LATS2, direct substr
31 (YAP) oncogenic activity through inhibiting large tumor suppressor (Lats1/2) core kinases of the Hip
32 which was first found in a Drosophila Discs-large tumor suppressor protein (also known as GLGF or PD
34 The human homologue of the Drosophila discs large tumor suppressor protein (hDlg), a member of the m
37 a mammalian homolog of the Drosophila discs large tumor suppressor protein and which also binds the
38 hDlg (human homolog of the Drosophila discs large tumor suppressor protein) PDZ (postsynaptic densit
39 , the mouse ortholog of the Drosophila discs-large tumor suppressor, results in congenital hydronephr
40 denomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in most colorec
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