ライフサイエンスコーパス: large-scale

1 ickel foam that is commercially available in large scale.

2 o assess current risks in small streams on a large scale.

3 functional effects of genomic mutations at a large scale.

4 y to demonstrate industrial applicability at large scale.

5 l health conditions and risk behaviours on a large scale.

6 d synchronous seed production (masting) over large scales.

7 e screening and mechanistic investigation at large scales.

8 A large-scale 3-year empirical study involving 1,144 parti

9 al spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer.

10 ing low-carbon technology that can help spur large-scale adoption of renewables.

11 mall-scale microelectromechanical systems to large scale aerospace and biomedical systems.

12 to the harmful environmental side effects of large-scale agriculture.

13 ed a few loci associated with the trait, but large-scale analyses are still lacking.

14 Herein we report a large-scale analysis of the behavior of PAINS in biologi

15 lar networks are synthetically accessible in large scale and exhibit outstanding mechanical propertie

16 A large-scale and facile production of SiC NWs is critical

17 ent populations, by bridging the gap between large-scale and fine-scale genetic mapping, can reveal n

18 d one-step synthesis technique that leads to large-scale and low-cost production of Si nanosheets (Si

19 in water-alkali electrolyzers is pivotal for large-scale and sustainable hydrogen production.

20 ound discovery pipeline, currently involving large scale animal testing.

21 Our results demonstrate the feasibility of large-scale aptamer multiplexing at a level that has not

22 Advances over the past 10 years have allowed large-scale assessment of one epigenetic mark in particu

23 roductivity due to a common forcing, such as large-scale atmospheric circulation (North Atlantic Osci

24 rgy on ZnO surfaces were performed using the large-scale Atomic/Molecular Massively Parallel Simulato

25 ay reflectivity measurements, accompanied by large-scale atomistic molecular dynamics simulations, ar

26 Here, we report the development of a large-scale atomistic scheme providing a microscopic ins

27 Defining the large-scale behavior of brain circuits with cell type sp

28 The I-TASSER-MR algorithm was tested in large-scale benchmark datasets and solved 36% more targe

29 Large-scale benchmark tests show that the new hybrid COF

30 Large-scale benchmarking of the method demonstrates an i

31 duced mortality across the Neotropics to the large-scale bioclimatic distributions of 115 tree genera

32 ions, consistent with the goal of predicting large-scale biosphere responses to global change.

33 A large-scale BLAST score ratio (LS-BSR) analysis was furt

34 rophoretic mobility has been developed using large-scale bottom-up proteomic CE-MS data (5% ( approxi

35 nectivity within and across well-established large-scale brain networks can be considerably heritable

36 tand how computations are implemented across large-scale brain networks.

37 cancer tissue samples, leading to the first large-scale breast cancer proteomics studies.

38 ation of recombination rate at both fine and large scales cannot be fully explained by DNA sequences

39 RCVD) technique for the in-situ synthesis of large scale carbon-coated non-magnetic metal oxide nanop

40 a conformationally adaptive dimer can drive large-scale cargo movement without the requirement for p

41 As proof-of-principle, we conducted large-scale cell cycle profiling of 884 FDA-approved dru

42 These large-scale changes in nuclear architecture were associa

43 nlinear response of a circumpolar seabird to large-scale changes in oceanographic conditions and indi

44 Large-scale characterisation of cysteine modification is

45 We present a large-scale characterization of exonic splicing mutation

46 rated application of deep metric learning to large-scale chemical genetics projects highlights the ut

47 ensitivity associations and the results from large-scale chemical screening using human cancer cell l

48 Here we show that large-scale chromatin remodelling occurs during Drosophi

49 say, basal micronuclei levels, the number of large-scale chromosomal rearrangements (LST), and the st

50 f a more harmonized approach to implementing large-scale CHW programs for HIV in the context of compl

51 We perform here large-scale classical and quantum molecular simulations

52 re, we present a framework for the automated large-scale classification of ion channel models.

53 hat are universal (e.g., higher temperature, large-scale climate oscillations) or whether they are mo

54 ations in the eastern United States based on large-scale climate patterns during the previous spring.

55 We used large-scale climatic and occurrence data of the solitari

56 -CoV for humans or animals, and there are no large-scale clinical trials for therapies against MERS-C

57 DeBooster will be widely applied to analyze large-scale CLIP-seq experimental data and can provide a

58 Large-scale CO2 hydrogenation could offer a renewable st

59 We find that this large-scale cold spell can be attributed to the concurre

60 Large-scale collaborative studies around the globe have

61 Here, we build a large-scale collection of related ligand pairs solved in

62 Three recent studies analyzing large-scale collections of human induced pluripotent ste

63 ajority of vitamin D testing is performed in large-scale commercial laboratories which have high oper

64 as a result might not provide comprehensive large scale community-wide exposure data.

65 In this study, a large-scale comparative metabolomics approach was applie

66 d that uses k-mers as genomic features for a large-scale comparison of complete viral genomes availab

67 djacent land during the growing season), the large-scale component might reflect co-variability of se

68 ment mechanisms and effect on performance of large scale composite structures.

69 y provinces are hypothesized to be caused by large-scale compositional heterogeneity (i.e., thermoche

70 e on VP5* with the membrane bilayer and on a large-scale conformational change.

71 spots of fluctuations that set the stage for large-scale conformational changes essential for translo

72 the complex it is only partially bent, with large-scale conformational changes in the C3 domains tha

73 Integrins undergo large-scale conformational changes upon activation.

74 ed and only 8.9% have strict protection, new large-scale conservation efforts to protect intact fores

75 ry (CMB), but returns within >/=100 Myrs via large-scale convection to its approximate starting locat

76 Large-scale cooperation is required to maintain contiguo

77 ied compensatory profile was associated with large-scale cortical reorganization, regardless of corti

78 tudied for some time, it remains unclear how large-scale cortico-cortical functional connectivity sys

79 ome short tandem repeat (Y-STR) profiling in large-scale crime investigations.

80 Thanks to the availability of large scale data for RBP binding motifs and in vivo bind

81 e Analysis, Translation, and Organization of large-scale data (PLATO), a software tool equipped to ha

82 ork infrastructure, to enable continuous and large-scale data acquisition in resource-constrained are

83 Here we exploit the large-scale data analysis techniques to study the mobile

84 , including the development of consortia and large-scale data collection projects and the use of nove

85 qualities and best practices that facilitate large-scale data integration.

86 l observation during weight restoration, and large-scale data pooling.

87 Technical advances and large-scale data sets have allowed for the development o

88 evaluate the product water quality from the large-scale DCMD treatment of oil and gas produced water

89 Since the 1960s, large-scale deforestation in the Amazon Basin has contri

90 the preserve of recent societies, linked to large-scale deforestation, extensive and intensive agric

91 Mice displayed low amounts of large-scale deletions and a dramatic depletion of mtDNA

92 (ORR) in acidic media, which is crucial for large-scale deployment of proton exchange membrane fuel

93 n spectrum-centric scoring can be adapted to large-scale DIA experiments that have been analyzed with

94 Historically, large-scale diagnostic test implementation has been slow

95 these multi-scale features are effective, on large-scale digital pathological images, the process of

96 atment to large numbers of patients during a large-scale disaster remains a concern.

97 whole-genome sequencing have facilitated the large-scale discovery of de novo variants in human disea

98 e glycosite localization, enabling the first large-scale discovery of O-glycosylation on signaling pe

99 relies heavily on centralized production and large scale distribution infrastructures to meet growing

100 e track routine mass drug administration-the large-scale distribution of deworming drugs-in Uganda.

101 D) of AhpF suggests that the enzyme adopts a large-scale domain motion that alternates between the cl

102 Results indicated that prolonged and large-scale droughts had a strong negative impact on tre

103 role in governing the depth and amplitude of large-scale dynamics at extratropical latitudes.

104 Our results provide a precedent for large-scale dynamics in a substrate-bound chaperone, whi

105 cteristics do not facilitate the analysis of large-scale, ecological sequence datasets such as those

106 Building upon results from two large-scale ecosystem drought experiments in the eastern

107 offer important insights into the underlying large-scale effects of DBS as well as in finding novel s

108 We report on the first large-scale effort to profile pretreatment HBs at diagno

109 Several large-scale efforts have systematically catalogued prote

110 ric disorders, fueling PsychENCODE and other large-scale efforts to comprehensively map neuronal and

111 Large-scale efforts to understand biology and health hav

112 Large-scale electric energy storage is fundamental to th

113 s an alternative to lithium ion batteries in large-scale energy storage applications owing to the low

114 geable batteries are promising solutions for large-scale energy storage.

115 ic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activ

116 Large-scale environmental epidemiologic studies often re

117 Using a large-scale epidemiological approach, we identified eosi

118 e determinants of polio transmission and its large-scale epidemiology remains a public health priorit

119 cs for quantifying circulating biomarkers in large-scale epidemiology.

120 of this MYOC mutation on IOP using data from large-scale European population panels (directly sequenc

121 rove overall OAC rates in AF patients, but a large-scale evaluation of their effects has not been con

122 rfarin in trials of atrial fibrillation, but large-scale evaluations in clinical practice are limited

123 tomatic urinary tract infections (UTIs), yet large-scale evaluations of bacteriuria management among

124 Conclusion Large-scale evidence indicates that the distribution of

125 lated with speciation rates, providing rare, large-scale evidence that rapid morphological change is

126 A large scale example on a 1000 sample data set demonstrat

127 ll other Martini models and opens the way to large-scale explicit-solvent molecular dynamics simulati

128 ntific literature and by collaborations with large-scale expression projects, GXD collects and integr

129 Here, we performed large-scale extracellular recordings in the striatum and

130 silicon processes that are suitable for the large-scale fabrication of high-performance devices.

131 Large-scale fabrication of precisely defined nanostructu

132 Here we use a large-scale factorial manipulation to assess the extent

133 e recognized during IAP, here we developed a large-scale FASP method (LFASP) for digestion of milligr

134 an helps to improve our understanding of the large-scale fate of DDTs in the Arctic.

135 ed as dMAGA-FCMD, which is able to deal with large-scale FCMs with up to 500 nodes.

136 gest that an adaptive magnetic map, tuned to large-scale features of ocean circulation, facilitates t

137 We measured large-scale filamentation of the hot electron distributi

138 cales of 10 ps, resulting in a commensurate large-scale filamentation of the magnetic field profile.

139 mammal population that exhibits non-cyclic, large-scale fluctuations in abundance.

140 The results employ the readout of large-scale fMRI networks and, by indicating multiple fu

141 an explain previously problematic aspects of large-scale forest mortality, such as why it can occur t

142 Large-scale forward genetic screens have been instrument

143 The recent availability of large-scale functional genomics resources provides an op

144 The human brain is organized into large-scale functional modules that have been shown to e

145 Large-scale gene-lifestyle or more generally gene-enviro

146 So far, to our knowledge, no large-scale genetic study of dementia with Lewy bodies h

147 obank and summary association results from 7 large-scale genome-wide association studies, we examined

148 A recent large-scale genome-wide study from our group predicted t

149 Large-scale genomic analyses of human cancers have catal

150 is study presents to our knowledge the first large-scale genomic comparison of SBA with colorectal ca

151 proof-of-concept study was performed using a large-scale genomic dataset from 4,200 patients with 9

152 tractable chromosome conformations, and the large-scale genomic organization is globally unaffected

153 Large-scale genomic studies have made major progress in

154 ces, and to analyze gene lists obtained from large-scale genomics experiments.

155 anization, from single node to subcircuit to large-scale GRNs and discuss how regulatory design featu

156 both necessary and valuable for facilitating large-scale GWAS in populations of African ancestry.

157 , we analyze summary association data from a large-scale GWAS of lipids and show that these improveme

158 Integrating large-scale GWAS with regional proteome data identifies

159 work cautions that summarizing findings from large-scale GWASs may have limited portability to other

160 between territorial animals can generate the large-scale hexagonal regularity of these patterns.

161 Using a large-scale, high-density multielectrode array, we recor

162 n probes based on microfabrication can yield large-scale, high-density recording but face challenges

163 Western-blotting on mouse cervix confirmed large scale histone de-acetylation in labor.

164 of how biodiversity can be jointly shaped by large-scale historical processes and recent human distur

165 Despite many advances in the study of large-scale human functional networks, the question of t

166 lack of quantitative ecological data before large-scale human impacts.

167 wheat Ms1 gene and discuss its potential for large-scale hybrid seed production in wheat.

168 We compare the simulations of two large-scale hydrological models, one of them accounting

169 ches are still costly and time consuming for large scale identification of enhancers across a variety

170 Large-scale identification of somatic structural variati

171 ly widely studied by structural analyses and large-scale imaging techniques, with the goal to deciphe

172 ns of NMs, which need to be addressed before large-scale implementation of NMs for water purification

173 was identified as a key bottleneck to future large-scale implementation.

174 Despite their large-scale implications, these interactions remain unqu

175 They can be produced at large scale in Escherichia coli and could thus make seco

176 incorporated TF binding sites identified via large-scale in vitro assays, chromatin accessibility, ev

177 One of the major challenges facing large-scale industrial applications utilizing natural ca

178 However, large-scale inference sets a high bar for both statistic

179 PPiSeq is therefore a powerful new tool for large-scale investigations of dynamic PPIs.

180 Here, based on a large-scale kinetic simulation and its comparison with M

181 Our method integrated large-scale literature data and gene expression data tha

182 We focus especially on large-scale liver models described either by genome scal

183 ests of such predictions require appropriate large-scale manipulations of intact, natural habitat tha

184 s support the hypothesis that LLSVPs signify large-scale mantle upwelling in two antipodal regions of

185 is of nanostructured ceria, facilitating its large-scale manufacturing using green, economic, non-tox

186 Here, we report large-scale mapping of the branchpoints from deep sequen

187 creasingly relevant role in this search, but large-scale materials screening efforts are hindered by

188 output, we have conducted in budding yeast a large-scale measurement of the activity of thousands of

189 anges in the structure of Med14 facilitate a large-scale Mediator rearrangement that is essential for

190 Anthropogenic activities have led to large-scale mercury (Hg) pollution in the Arctic.

191 Recent large-scale meta-analyses have combined studies of diffe

192 Large-scale meta-analyses of genome-wide association stu

193 matic and chemoinformatic tools for handling large-scale metabolomics data, methods for elucidating t

194 Applying FishTaco to several large-scale metagenomic cohorts, we show that shifts in

195 cales of >1,000 km and clearly coincide with large-scale meteorological features.

196 , we present a novel technique that combines large-scale micro-electrode array recordings with geneti

197 ere are considerable challenges in analyzing large-scale molecular data.

198 model polycrystalline electrolyte, we apply large-scale molecular dynamics simulations to analyze th

199 Large-scale molecular profiling data have offered extrao

200 Using large-scale multi-omics cancer datasets, we show that In

201 Prospective, large-scale multicenter studies to validate the result a

202 d hand searching were reviewed to identify 6 large-scale, multicenter clinical trials.

203 All three extremes occur primarily in large-scale, multiday, spatially connected episodes with

204 -mediated nucleotide-conversion strategy for large-scale mutational analysis (RESA-bisulfite).

205 of maternal infection as well as the lack of large-scale neonatal screening tools.

206 alysis method that tracks dynamic changes in large-scale network cohesion by quantifying the level of

207 important step toward defining dystonia as a large-scale network disorder, understanding its causativ

208 per-synchronicity of functionally-segregated large scale networks and an abnormal pattern of neural a

209 l evoked potentials within and between three large-scale networks of the brain, the default network (

210 biological models of memory have argued that large-scale neural oscillations are reinstated to suppor

211 We show that during seizure large-scale neural populations spanning centimetres of c

212 Here, we present the results of a large-scale neuroimaging consortium study on PTSD conduc

213 Here we believe we performed the first large-scale next-generation targeted sequencing study of

214 This paper presents large-scale numerical simulations of zone annealing and

215 took forward for replication in independent large-scale OA datasets, and subsequent meta-analysis wi

216 This seasonal predictability results from large-scale ocean-atmosphere interactions.

217 Large-scale oil production from oil sands deposits in Al

218 the DO population is highly concordant with large-scale (order 10 Mb) features of previously reporte

219 ogically relevant stomatal flux-based index, large-scale ozone risk assessment is still complicated b

220 reproducibility compares favorably to other large-scale perturbational profiling studies such as the

221 ve been developed to conduct high-throughput large-scale phenotyping on animals, plants and humans, a

222 prehensive combination of tools that include large-scale phylogenetic reconstruction to determine the

223 resilience and its ability to rebound after large-scale population loss.

224 oring schemes and global network aligners on large scale PPI data and observe that three methods, HUB

225 rapid and efficient methods which can handle large-scale problems still need to be developed.

226 le stability, such a hybrid is promising for large scale production for practical applications where

227 ate that our method will provide a means for large-scale production of this HCV vaccine candidate.

228 ld promise as a sustainable resource for the large-scale production of triptolide.

229 We used the L1000 platform for large-scale profiling of 978 representative genes across

230 We established a large-scale, prospective clinical sequencing initiative

231 However, retrieving biological insights from large-scale protein dynamics data remains a challenging

232 s Quantitation), that automatically performs large-scale proteoform quantitation based on interspectr

233 oth high-efficiency protein purification and large-scale proteomics analysis of cell or tissue lysate

234 nerative response, we performed quantitative large-scale proteomics analysis of cytoplasmic and nucle

235 These results highlight the power of large-scale proteomics to identify key players in liver

236 A 100 x 100 large-scale PSM gives both electrical and optical signal

237 ncluding evaluation of key studies assessing large-scale quality improvement efforts in the ICU, impa

238 Finally, we show the use of VTEA for large-scale quantitation of immune cells in entire human

239 These results deliver large-scale quantitative evidence linking climate and ag

240 emonstration can also enable the assembly of large scale quantum information systems and open up new

241 rpretation of precipitation-proxy records as large-scale rainbelt movement challenging, requiring reg

242 In the era of drug-eluting stents, large-scale randomized trials and all-comer registries h

243 The in situ observations, combined with large-scale reactive molecular dynamics simulations, rev

244 Large-scale, real-world assessment of physical activity,

245 dicators is a widely used imaging method for large-scale recording of neural activity in vivo.

246 performance can be dynamically tuned over a large scale remain rare.

247 ns, as in animals, heterochromatin undergoes large-scale remodeling to create a compartment with low

248 olution for self-powered sensor networks and large-scale renewable blue energy.

249 The large-scale reorganization of deep ocean circulation in

250 Here we report large-scale reprogramming of chromatin modifications dur

251 rotein stability calculations, summarize the large-scale retrospective validation results, and discus

252 Large-scale RNA-binding pockets on protein surfaces are

253 We address challenges of analyzing large-scale RNA-seq data via several new developments to

254 riation in microbiomes across hosts, despite large-scale sampling efforts.

255 e, and produces good to moderate yields on a large scale, sans chromatography, and thus fulfills this

256 These cells permit sensitive, large-scale screening and titration of infectious virus

257 Application to several large-scale screening data sets on nuclear and mitotic c

258 The large scale seepage reported here is not caused by anthr

259 lications such as phylogenetic inference for large-scale sequences.

260 ainst misleading characters than can pollute large-scale sequencing data.

261 Large-scale sequencing of environmental microbiomes has

262 imately 1000 de novo mutations discovered by large-scale sequencing of family samples, 215 genes span

263 The emerging synergy between large-scale simulations and 3D printing is having a two-

264 xpensive, and are therefore not suitable for large-scale simulations of cellular electrical activity.

265 igh-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to defi

266 ymorphisms (SNPs) were selected to develop a large-scale SNP genotyping array.

267 r splitting provides an attractive route for large-scale solar energy storage, but issues surrounding

268 in the tropics, where climate variation over large-scale space is asynchronous.

269 We demonstrate with large-scale spiking activity recordings a concurrent der

270 in phenotyping of pluripotent stem cells for large scale stem cell culture expansion and differentiat

271 al.'s bottom-up approach, we conducted four large-scale studies designed to assess people's concepti

272 Few large-scale studies have considered both food sources an

273 Large-scale studies have revealed how editing is regulat

274 ying gene-environment interactions (GxEs) in large-scale studies of human populations.

275 ed genes has long fascinated biologists, but large-scale studies of their expression dynamics and mol

276 n, as well as the scarcity of comprehensive, large-scale studies that assess both the genomic landsca

277 Especially in large-scale studies, normalization is crucial for drawin

278 rent reference haplotypes are inadequate for large-scale studies.

279 Robust, large-scaled studies are required to better quantify the

280 We performed a large-scale study by creating breast cancer metastasis n

281 This large-scale study investigating key aspects of the PANDA

282 In a large-scale study involving 55 species and 550 populatio

283 ed that ponds often form part of widespread, large-scale surface drainage systems.

284 opic of downstream processes, especially for large scale synthesis, is critically reviewed.

285 kcal/mol compared to that in 3, allowing the large-scale synthesis and isolation of the trifluorotolu

286 enefit for further development and practical large-scale synthesis of CTFs.

287 ies, which can offer practical solutions for large-scale tissue measurements.

288 lication has been successfully rolled out at large scale to HIV-positive patients in low-income and m

289 , and can be easily and repeatedly used on a large scale to monitor the progression of liver patholog

290 remains untested, as we lack information on large-scale trait variation for riparian litter.

291 In the last decade, several large-scale transcriptome and interactome studies were c

292 Large-scale transcriptome sequencing efforts have vastly

293 e material-based interventions to regenerate large scale, traumatic injuries.

294 old reduction in catalytic rate in vitro and large-scale trinucleotide (GAA)n repeat expansions in vi

295 A large scale-up of eye care provision to cope with the in

296 ngineered nanomaterials being considered for large-scale use, this high-throughput screening method w

297 The medium- and large-scale vessels were run for 52 consecutive weeks as

298 d [8]AGNR, which can now be synthesized on a large scale via two operationally simple and discrete so

299 icates that humans and other species process large-scale visual information before fine spatial detai

300 that environmental heterogeneity will affect large-scale Wolbachia transformations of urban mosquito