1 specific cancer-associated Parkin mutations
largely abolish the functions of Parkin to ubiquitinate
2 in the neck and base of dendritic spines and
largely absent from spine heads.
3 ancer, therapeutic STAT inhibitors are still
largely absent from the clinic.
4 he POU domain TF Ventral veins lacking (Vvl)
largely ameliorates the airway morphogenesis defects of
5 As a result, it has been
largely assumed that the contribution of fungi to allerg
6 they nevertheless arrange themselves into a
largely asymmetric structure made of hexamers and pentam
7 ited States and Canada over the past decade,
largely attributable to a notable increase in donation a
8 onentially as kidney function worsens and is
largely attributable to death from cardiovascular diseas
9 Reperfusion injury is
largely attributed to excess mitochondrial production of
10 stage kidney disease, an association that is
largely attributed to two common genetic variants, terme
11 The compensatory force patterns were
largely based on the perturbation kinematic (e.g., veloc
12 l types from the rat central nervous system,
largely based on the relative proportions of four domina
13 itors for clinical use have thus far failed,
largely because of a lack of adequate small-molecule-bin
14 rt for Branigan & Pickering's (B&P's) model,
largely because the priming effects are more confusing a
15 lthough definitions and diagnosis of AD have
largely been agreed upon, allergists and dermatologists
16 ment for myocardial infarction in China have
largely been eliminated, substantial gaps in quality of
17 (III)-catalyzed C-H activation reactions has
largely been limited to cyclopentadienyl (Cp) based scaf
18 l role of the thalamic input to L4 in M1 has
largely been neglected, but our data suggest that, as in
19 ), their induction of robust CD8 T cells has
largely been unreported, even though evidence for the im
20 Metacyclics have a
largely bloodstream-form type transcriptome, and thus ar
21 nd MM originate early in life and are driven
largely by height and birth weight, without any comparab
22 ito-temporal cortex specialization is driven
largely by inherited connectivity constraints that do no
23 cial/ethnic survival disparities were driven
largely by reductions for black compared with white pati
24 ased culture supernatant sialidase activity,
largely by stimulating nanI transcription.
25 ch for better stimulation protocols proceeds
largely by trial and error.
26 cy, indicating that the workflows arrived at
largely complementary sets of valid SNP calls on the low
27 thods have strengths and weaknesses that are
largely complementary.
28 A new,
largely complete eusauropod dinosaur with cranial and po
29 on, innate immunity to a DeltaICP0 virus was
largely compromised, and that permitted ICP0-deficient m
30 ity associated with cyanobacterial blooms is
largely conserved at the phylum level, with Proteobacter
31 sion patterns and RFRP-3/GnRH cross-talk are
largely conserved in the NMR brain, with the exception o
32 netic analysis reveals interactions that are
largely consistent with our model.
33 eplication describes a highly-processive and
largely continuous process by which the genome is duplic
34 physiologically beneficial in the heart, it
largely contributes to cardiac disease progression when
35 Consequently, ClpG
largely contributes to heat tolerance of P. aeruginosa p
36 The repressive status of chromatin
largely contributes to HIV latency.
37 sting that the canalization of metabolism is
largely controlled by regulatory genes.
38 modynamics and kinetics of H2O splitting are
largely controlled by the inherent redox properties of t
39 Both mitochondrial and barrier defects were
largely corrected by targeting Stard7 to mitochondria or
40 restrictively expressed in RGB cones, which
largely define the beginning of the color vision pathway
41 mia from classic BCR-ABL1(-) MPNs, which are
largely defined by mutations in JAK2, CALR, or MPL In th
42 Using this panel, we have
largely defined the carbohydrate specificities of each P
43 Current pest management programs
largely depend on chemical insecticides, resulting in hi
44 ncements of population-level representations
largely depend on position shifts of vRFs, rather than c
45 or parasite survival within these niches has
largely depended on comparative transcriptomic and prote
46 epends on morphology and not absorbance that
largely depends on the volume of material.
47 ver, knowledge of human antiviral T cells is
largely derived from blood.
48 firming that Se dose and developmental stage
largely determine the behaviour of the system.
49 the early intermittent silencing phase that
largely determine their final life spans.
50 We demonstrate that expression levels
largely determine whether MDGAs act selectively or suppr
51 Cell mass is
largely determined by the amount of water, proteins, lip
52 nfluenced by plant species diversity, but is
largely determined by the temporal stability of dominant
53 potential of scar-forming myofibroblasts are
largely determined by their origin.
54 These changes are
largely determined by tree mortality, which should be fu
55 ive model (AUC = 0.77), physician preference
largely determined which medication a patient received (
56 Xi was
largely devoid of mCH, whereas Xa contained abundant mCH
57 role of cardiac imaging has expanded from a
largely diagnostic tool to an adjunctive tool to guide i
58 ary, the faulted margins of the Gulf display
largely dip-slip extensional movement and accompanying f
59 on among individuals of African descent, has
largely disappeared in these regions.
60 This conclusion was
largely dismissed after an experimental study involving
61 f two-pore potassium channel (K2P) subunits,
largely dispensable early in life, are necessary for ter
62 Exg8 is
largely dispensable for virulence in vivo, in contrast t
63 o describe the changes from a field that was
largely dominated by UK and North American biologists to
64 yhaline estuaries where ammonia-oxidation is
largely driven by AOB.
65 iods (66% vs 58% vs 51%; P = .001), a change
largely driven by improved VGPR rates in the non-ASCT po
66 y in bioavailability of CNM-adsorbed PAHs is
largely driven by PAH size, configuration and surface ar
67 Mitotic area expansion is
largely driven by regulation of cytoplasmic pressure.
68 pRF size in early retinotopic visual cortex
largely due to reduced inhibitory surrounds.
69 This disconnect is
largely due to the different spatial scales considered b
70 roliferation during allergic inflammation is
largely due to the recruitment of monocytes and dendriti
71 rticles but the origin of this dependence is
largely due to the scattering that depends on morphology
72 e, insulin resistance in obesity seems to be
largely elicited downstream of these steps.
73 e primary causes of age-dependent EFA remain
largely elusive.
74 affect common downstream mechanisms remains
largely elusive.
75 rams and thereby regulate angiodiversity are
largely elusive.
76 ric, intestinal and colonic fluids, and thus
largely enriched the SDS and RS fractions in starch.
77 veal a patient missense variant, L344P, that
largely escapes proteasomal surveillance and shows subtl
78 rable with figures from other populations of
largely European ancestry.
79 demonstrate that serotonergic afferents are
largely excitatory for mitral cells (MCs) in the MOB whe
80 monocultural plantings of nonnative plants,
largely excluding native species from cropland.
81 cantly affect tertiary folding and appear to
largely explain previously observed variations in hairpi
82 invasive community-associated MRSA rates was
largely explained by socioeconomic factors.
83 Here we show that this variability is
largely explained by the remote Atlantic multidecadal os
84 Furthermore, these neurons
largely express corticotrophin-releasing hormone or thyr
85 to identify driver mutations in cancer have
largely focused on genes, whereas non-coding sequences r
86 While previous work has
largely focused on in vitro cellular models, here we dem
87 on and multimodel comparisons with data have
largely focused on individual processes at subannual to
88 Assessments
largely focused on national bans of specific pesticides
89 However, this literature has
largely focused on the effects of current family circums
90 CB intake on mouse hippocampal interneurons
largely focusing on cholecystokinin-expressing interneur
91 applies, any octet expansion is now seen as
largely formal, however, because the central element ess
92 ron emission tomography signal, which arises
largely from microglial activation, and measures of subs
93 T2DM arises
largely from obesity, poor diet, and lack of exercise, b
94 However, we have
largely ignored how the differentiation into the NKT cel
95 luene are major abundant dietary carotenoids
largely ignored in the context of agro-food and health.
96 Pathogenic Htt is present
largely in a nonaggregated form at synapses, indicating
97 KCNQ1 is
largely in an intracellular reservoir under basal condit
98 cell labeling showed Tac1-Pet1 soma resident
largely in the caudal medulla.
99 Changes in Nab3 binding are
largely independent of alterations in transcription rate
100 t for determining drought tolerance, and are
largely independent of wood density-a trait commonly ass
101 ing factors in earlier assessments that were
largely indirect.
102 We know that this is
largely ineffective with resistance arising in most tumo
103 The compaction reactions are
largely insensitive to DNA torsional stress.
104 Even though this quantity is believed to be
largely insensitive to nuclear structure and therefore t
105 While the plasma membrane proteome remained
largely invariable, we observed pronounced alterations i
106 Although the atomic structure of T4 is
largely known, the dynamics of its fascinating injection
107 nal microbiota of reproductive-aged women is
largely made up of at least five different community sta
108 nversely, ectopic expression of Dmrt1 led to
largely masculinized genetic females, production of Amh
109 he anticancer activities of these precursors
largely match their self-assembling abilities.
110 pect to free triplets with an energy that is
largely material independent ( approximately 30 meV).
111 tively fast evolution and have only a minor,
largely modulatory role in gene regulation under diverse
112 Pain is a
largely neglected symptom in patients with amyotrophic l
113 iolence victimization and later cognition is
largely noncausal, in contrast to conventional interpret
114 nconventional path to access this previously
largely obscure class of cyclooctatetraenyl radicals, wh
115 tral and claustrocortical connections remain
largely obscure.
116 or the different conformations have remained
largely obscure.
117 Morphologically, the enrichment consisted
largely of planktonic cells with an average characterist
118 owever, past functional studies have focused
largely on seed production; although useful, this focus
119 The urgency of the transition will depend
largely on the country-specific prevalence of NNRTI resi
120 able properties of hydrogel particles depend
largely on their size, and particles ranging from nanome
121 bre at the univariate level of analysis were
largely overlapping.
122 al mnemonic operation that has thus far been
largely overlooked in memory research.
123 CO and longer-lived VOCs,
largely overlooked in previous studies, extend the influ
124 A
largely overlooked property of antibodies is their funct
125 hium transition-metal oxides (TMOs) has been
largely overlooked.
126 of neuropil excitatory-inhibitory structure
largely precedes dendritic arborization of primary motor
127 Conversely, CTCF binding sites in NPCs are
largely preexisting in pluripotent stem cells.
128 nd P301S/E3 mice, whereas P301S/EKO mice are
largely protected from these changes.
129 adiotherapy (n = 85), tracer sensitivity was
largely PSA-independent.
130 visual metronome found their movements to be
largely reactive, not predictive.
131 ptera, and it includes medium-size lacewings
largely recognized by the presence of golden-colored eye
132 Whereas establishment is
largely related to event-level factors, apparently stoch
133 een based on the flow-limited assumption and
largely rely on in vivo data for parametrization.
134 of these subpopulations to the injured brain
largely remains unknown.
135 ent (Lep(ob/ob) ) mice and this phenotype is
largely rescued by neonatal leptin treatments.
136 these results suggest that the microbiome is
largely resistant to changes during sleep restriction.
137 sceptibility to bacterial infection and were
largely resistant to endotoxin-induced septic shock.
138 Mechanistically, HDAC3 activity is
largely responsible for histone deacetylation and inflam
139 eage and that English Thoroughbred sires are
largely responsible for the predominance of this haploty
140 cells) and evening oscillators (E cells)-are
largely responsible for these activity bursts.
141 t1's silencing effect on Foxa1 expression is
largely responsible for Twist1-induced migration, invasi
142 der phase transformations with slow kinetics
largely restricted by the nucleation and growth of a new
143 We demonstrated that CD25 expression is
largely restricted to tumor-infiltrating Treg cells in m
144 that the intrinsically low activity of Ubc15
largely results from the presence of an acidic residue a
145 signals, finding that signaling dynamics are
largely robust to interference.
146 thicker multiyear ice cover to a thinner and
largely seasonal first-year ice cover with significant c
147 ptor activation, and activated receptors are
largely sequestered from G proteins upon internalization
148 cuprate high-temperature superconductors are
largely shaped by competing phases whose nature is often
149 ged to form an enclosed aqueous pore that is
largely shielded from the membrane.
150 e that T cell responses to rDENV2Delta30 are
largely similar to those to natural infection in terms o
151 ion varies widely between individuals but is
largely stable over time within individuals [4, 5].
152 This conclusion
largely stems from polar research, with less attention p
153 f early jawless vertebrates, a role that was
largely subsumed by vagal neural crest cells in early gn
154 lipids and show that these improvements are
largely sustained in real data.
155 By proposing that the 1st Hit is
largely telomere length-independent, while the 2nd Hit i
156 ding of the function of facilitation remains
largely theoretical.
157 al array of firing fields, a pattern that is
largely thought to reflect the operation of intrinsic se
158 mationally flexible molecules was determined
largely through J-based configurational analysis, but ha
159 ere length-independent, while the 2nd Hit is
largely TL-dependent, we resolve the paradox, highlighti
160 k bNAb binding to E2, and neutralization was
largely toward the homologous genotype.
161 lated strain, USA300 also seems to have been
largely unable to establish itself as an endemic infecti
162 at the overall pace of marsh development was
largely unaffected by whether the upland being invaded w
163 l sensitivity whereas the fellow eye (FE) is
largely unaffected.
164 e to genotype, and cell wall composition was
largely unaffected.
165 TH 2 immunity as TH 1 and TH 17 immunity is
largely unaffected.
166 ainly in native species (-19%), but remained
largely unchanged in exotic species.
167 hile deep Southern Ocean temperature remains
largely unchanged.
168 quences of disruption of this complex remain
largely uncharacterized.
169 sites across the mammalian proteome, remain
largely uncharacterized.
170 e ability of SCVs to resist host defenses is
largely uncharacterized.
171 atial scales larger than single neurons, are
largely uncharted.
172 uronal inflammation and degeneration remains
largely unclear and presumably depends on the insult typ
173 endent genes during neuronal activity remain
largely unclear.
174 fine-tuning double flower formation remains
largely unclear.
175 surface receptors, including GPCRs, remains
largely unclear.
176 ffected stem cells and somatic cells remains
largely unclear.
177 of the vascular inflammatory state is still
largely unclear.
178 nces repeatedly concludes that Americans are
largely unconcerned about it.
179 utions travel easily and quickly, yet remain
largely uncredited.
180 cues that position cells in this region are
largely undefined.
181 cer cells, but the underlying mechanisms are
largely undefined.
182 r; however, its role in tumor development is
largely undefined.
183 ion Older patients with breast cancer remain
largely underrepresented in cooperative group therapeuti
184 Once we understand emotion in simulation, we
largely understand emotion in tragedy (and fiction).
185 larly conspicuous within angiosperms, but is
largely unexplained.
186 vival of pelagic adults and juveniles remain
largely unexplored and no study has simultaneously explo
187 d CpcA-PCB demonstrate the potential of this
largely unexplored protein family as novel probes for su
188 breather solitons in microresonators remains
largely unexplored, and its experimental characterizatio
189 m of lncRNA-mediated gene regulation remains
largely unexplored, particularly in plants where their a
190 aintain systemic glucose homeostasis remains
largely unexplored.
191 ogical functions of these proteins have been
largely unexplored.
192 ith supramolecular host systems has remained
largely unexplored.
193 ed, but their functional consequences remain
largely unexplored.
194 tcome-specific conditioned inhibition remain
largely unexplored.
195 ut the role of this region of the channel is
largely unexplored.
196 ng with the retinal chromophore has remained
largely unexplored.
197 cal determinants of viral persistence remain
largely unexplored.
198 genetic programs underlying behavior remain
largely unexplored.
199 ions in guiding structure formation is still
largely unexplored.
200 s concerning the asymmetric hydrogenation of
largely unfunctionalized olefins, from the first reports
201 The microwave signals are
largely uniform across grains and grain boundaries, sugg
202 should be considered failed trials that are
largely uninformative and not eligible to be included in
203 tions of these imprinted genes have remained
largely uninvestigated.
204 with and without agoraphobia (AG) are still
largely unknown and progress is hampered by small sample
205 a (ACC) is an aggressive exocrine tumor with
largely unknown biology.
206 cific physiological tau functions, which are
largely unknown but could contribute to neuronal dysfunc
207 activated and other neurochemical content is
largely unknown hence whether stimulus specific populati
208 However, it is still
largely unknown how gut dysbiosis affects the onset and
209 veryday hearing environment, it has remained
largely unknown what neural mechanisms are used by the p
210 However, it is
largely unknown which genes and alleles adjust plant gro
211 tional regulation, and heterogeneity remains
largely unknown, hampering their clinical use.
212 elective markers for MOB interneurons remain
largely unknown, limiting mechanistic understanding of o
213 upereruption activity, or resurgence, remain
largely unknown, limiting our ability to understand how
214 f Dlg4/PSD95, or other plasticity genes, are
largely unknown, limiting the development of targeted ep
215 uishes fatal from non-fatal outcomes remains
largely unknown, yet is key to optimising personalised t
216 that specify human microglia phenotypes are
largely unknown.
217 s and their impact on adult neurogenesis are
largely unknown.
218 o orchestrate specific band activity remains
largely unknown.
219 regulating these complex processes are still
largely unknown.
220 onsible for mediating this protection remain
largely unknown.
221 e pathogenic mechanisms of these viruses are
largely unknown.
222 and beta cleavage of APP at synapses remain
largely unknown.
223 properties of these heteromers have remained
largely unknown.
224 and factors controlling MARCH5 activity are
largely unknown.
225 eir composition, dynamics, and functions are
largely unknown.
226 he mechanisms that permit this growth remain
largely unknown.
227 ling outcomes through mechanisms that remain
largely unknown.
228 various body patterns by the optic lobe are
largely unknown.
229 tressors at local-to-regional scales remains
largely unknown.
230 (miRs) regulate IOP and glaucoma in vivo is
largely unknown.
231 , its tumorigenic function in MPNSTs remains
largely unknown.
232 in and significance of these profiles remain
largely unknown.
233 nd the dynamics of the gating components are
largely unknown.
234 heir functions in SMC differentiation remain
largely unknown.
235 ar mechanisms underlying this process remain
largely unknown.
236 Its impact on glioblastoma remains
largely unknown.
237 ction and regulation of these domains remain
largely unknown.
238 However, its developmental mechanisms remain
largely unknown.
239 hways contributing to these processes remain
largely unknown.
240 gnaling changes in developing tissues remain
largely unknown.
241 ilure (HF), but the outcome by type of AF is
largely unknown.
242 and postoperative clinical outcomes remains
largely unknown.
243 ow BRD4 is regulated in cancer cells remains
largely unknown.
244 mitochondrial isoform of OGT (mOGT) remains
largely unknown.
245 ganization of diverse thalamic nuclei remain
largely unknown.
246 mice; however, the underlying mechanisms are
largely unknown.
247 s long-term consequences on mortality remain
largely unknown.
248 ty; however, its molecular mechanisms remain
largely unknown.
249 g dependence-induced neuroadaptations remain
largely unknown.
250 ally harmful action of apoptotic caspases is
largely unknown.
251 echanisms of their function in complexes are
largely unknown.
252 ver, how repair is initiated at telomeres is
largely unknown.
253 the brain when taken as a drug of abuse are
largely unknown.
254 characteristics are maintained afterward is
largely unknown.
255 -containing proteins in human cancer remains
largely unknown.
256 onsible for such adaptive homeostasis remain
largely unknown.
257 e electron transfer in these systems remains
largely unknown.
258 have adapted to this extreme environment is
largely unknown.
259 the molecular steps of synaptogenesis remain
largely unknown.
260 t its precise function and substrates remain
largely unknown.
261 echanisms underlying acquired resistance are
largely unknown.
262 a cells; however, its mechanism of action is
largely unknown.
263 nd cardiovascular risk factors to LA size is
largely unknown.
264 associated macrophage differentiation remain
largely unknown.
265 ing urothelial formation and maintenance are
largely unknown.
266 ributes to brain AD-type pathologies remains
largely unknown.
267 critical for food and livelihood security is
largely unknown.
268 mechanisms that result in this phenotype are
largely unknown.
269 of a permanent expression of these genes are
largely unknown.
270 talytically relevant protein motions remains
largely unknown.
271 der in adults and children whose etiology is
largely unknown.
272 ow McSCs respond to injury, however, remains
largely unknown.
273 rial versus ventricular specification remain
largely unknown.
274 tensive thalamocortical connectivity remains
largely unknown.
275 affect MEK1 regulation and function remains
largely unknown.
276 t of dead cells in the infarcted area remain
largely unknown.
277 of neurons and ultimately brain circuits is
largely unknown.
278 y are assembled to create the exosporium are
largely unknown.
279 otrusions, but the underlying mechanisms are
largely unknown.
280 dark-induced cytoskeletal arrangement remain
largely unknown.
281 late the vasculature outside the CNS remains
largely unknown.
282 e and regulate their expression profiles are
largely unknown.
283 rinsic properties of this material are still
largely unknown.
284 ical dendrite with further branches, remains
largely unknown.
285 he mechanical behaviour of crustal rocks are
largely unknown.
286 a normal brain into an epileptic one remain
largely unknown.
287 he onset and progression of the syndrome are
largely unknown.
288 properties and molecular identity are still
largely unknown.
289 ractions with developmental programs, remain
largely unknown.
290 utations prescribed by model-based RL remain
largely unknown; however, multiple lines of evidence sug
291 is obscured by uncertainty arising from four
largely unobserved processes: transmission, case observa
292 In addition, RSV's importance as a
largely unrecognized pathogen of debilitated older peopl
293 d signaling through mechanisms that appeared
largely unrelated to DJ-1 antioxidant activity.
294 grees C to 4.5 degrees C or greater -remains
largely unscathed by the onslaught of new scientific ins
295 unactivated, hindered halides persists as a
largely unsolved challenge in organic synthesis.
296 Nsg2 is
largely unstudied.
297 sympathetic nerves, causes vasoconstriction
largely via P2X1 receptors.
298 potential revenue from a food that is still
largely wasted.
299 igated severe skin disease in a European and
largely white study population.
300 studied electrophysiologically for decades,
largely with ex vivo approaches that disrupt the photore