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1  specific cancer-associated Parkin mutations largely abolish the functions of Parkin to ubiquitinate
2 in the neck and base of dendritic spines and largely absent from spine heads.
3 ancer, therapeutic STAT inhibitors are still largely absent from the clinic.
4 he POU domain TF Ventral veins lacking (Vvl) largely ameliorates the airway morphogenesis defects of
5                     As a result, it has been largely assumed that the contribution of fungi to allerg
6  they nevertheless arrange themselves into a largely asymmetric structure made of hexamers and pentam
7 ited States and Canada over the past decade, largely attributable to a notable increase in donation a
8 onentially as kidney function worsens and is largely attributable to death from cardiovascular diseas
9                        Reperfusion injury is largely attributed to excess mitochondrial production of
10 stage kidney disease, an association that is largely attributed to two common genetic variants, terme
11         The compensatory force patterns were largely based on the perturbation kinematic (e.g., veloc
12 l types from the rat central nervous system, largely based on the relative proportions of four domina
13 itors for clinical use have thus far failed, largely because of a lack of adequate small-molecule-bin
14 rt for Branigan & Pickering's (B&P's) model, largely because the priming effects are more confusing a
15 lthough definitions and diagnosis of AD have largely been agreed upon, allergists and dermatologists
16 ment for myocardial infarction in China have largely been eliminated, substantial gaps in quality of
17 (III)-catalyzed C-H activation reactions has largely been limited to cyclopentadienyl (Cp) based scaf
18 l role of the thalamic input to L4 in M1 has largely been neglected, but our data suggest that, as in
19 ), their induction of robust CD8 T cells has largely been unreported, even though evidence for the im
20                           Metacyclics have a largely bloodstream-form type transcriptome, and thus ar
21 nd MM originate early in life and are driven largely by height and birth weight, without any comparab
22 ito-temporal cortex specialization is driven largely by inherited connectivity constraints that do no
23 cial/ethnic survival disparities were driven largely by reductions for black compared with white pati
24 ased culture supernatant sialidase activity, largely by stimulating nanI transcription.
25 ch for better stimulation protocols proceeds largely by trial and error.
26 cy, indicating that the workflows arrived at largely complementary sets of valid SNP calls on the low
27 thods have strengths and weaknesses that are largely complementary.
28                                       A new, largely complete eusauropod dinosaur with cranial and po
29 on, innate immunity to a DeltaICP0 virus was largely compromised, and that permitted ICP0-deficient m
30 ity associated with cyanobacterial blooms is largely conserved at the phylum level, with Proteobacter
31 sion patterns and RFRP-3/GnRH cross-talk are largely conserved in the NMR brain, with the exception o
32 netic analysis reveals interactions that are largely consistent with our model.
33 eplication describes a highly-processive and largely continuous process by which the genome is duplic
34  physiologically beneficial in the heart, it largely contributes to cardiac disease progression when
35                           Consequently, ClpG largely contributes to heat tolerance of P. aeruginosa p
36           The repressive status of chromatin largely contributes to HIV latency.
37 sting that the canalization of metabolism is largely controlled by regulatory genes.
38 modynamics and kinetics of H2O splitting are largely controlled by the inherent redox properties of t
39  Both mitochondrial and barrier defects were largely corrected by targeting Stard7 to mitochondria or
40  restrictively expressed in RGB cones, which largely define the beginning of the color vision pathway
41 mia from classic BCR-ABL1(-) MPNs, which are largely defined by mutations in JAK2, CALR, or MPL In th
42                    Using this panel, we have largely defined the carbohydrate specificities of each P
43             Current pest management programs largely depend on chemical insecticides, resulting in hi
44 ncements of population-level representations largely depend on position shifts of vRFs, rather than c
45 or parasite survival within these niches has largely depended on comparative transcriptomic and prote
46 epends on morphology and not absorbance that largely depends on the volume of material.
47 ver, knowledge of human antiviral T cells is largely derived from blood.
48 firming that Se dose and developmental stage largely determine the behaviour of the system.
49  the early intermittent silencing phase that largely determine their final life spans.
50        We demonstrate that expression levels largely determine whether MDGAs act selectively or suppr
51                                 Cell mass is largely determined by the amount of water, proteins, lip
52 nfluenced by plant species diversity, but is largely determined by the temporal stability of dominant
53 potential of scar-forming myofibroblasts are largely determined by their origin.
54                            These changes are largely determined by tree mortality, which should be fu
55 ive model (AUC = 0.77), physician preference largely determined which medication a patient received (
56                                       Xi was largely devoid of mCH, whereas Xa contained abundant mCH
57  role of cardiac imaging has expanded from a largely diagnostic tool to an adjunctive tool to guide i
58 ary, the faulted margins of the Gulf display largely dip-slip extensional movement and accompanying f
59 on among individuals of African descent, has largely disappeared in these regions.
60                          This conclusion was largely dismissed after an experimental study involving
61 f two-pore potassium channel (K2P) subunits, largely dispensable early in life, are necessary for ter
62                                      Exg8 is largely dispensable for virulence in vivo, in contrast t
63 o describe the changes from a field that was largely dominated by UK and North American biologists to
64 yhaline estuaries where ammonia-oxidation is largely driven by AOB.
65 iods (66% vs 58% vs 51%; P = .001), a change largely driven by improved VGPR rates in the non-ASCT po
66 y in bioavailability of CNM-adsorbed PAHs is largely driven by PAH size, configuration and surface ar
67                    Mitotic area expansion is largely driven by regulation of cytoplasmic pressure.
68  pRF size in early retinotopic visual cortex largely due to reduced inhibitory surrounds.
69                           This disconnect is largely due to the different spatial scales considered b
70 roliferation during allergic inflammation is largely due to the recruitment of monocytes and dendriti
71 rticles but the origin of this dependence is largely due to the scattering that depends on morphology
72 e, insulin resistance in obesity seems to be largely elicited downstream of these steps.
73 e primary causes of age-dependent EFA remain largely elusive.
74  affect common downstream mechanisms remains largely elusive.
75 rams and thereby regulate angiodiversity are largely elusive.
76 ric, intestinal and colonic fluids, and thus largely enriched the SDS and RS fractions in starch.
77 veal a patient missense variant, L344P, that largely escapes proteasomal surveillance and shows subtl
78 rable with figures from other populations of largely European ancestry.
79  demonstrate that serotonergic afferents are largely excitatory for mitral cells (MCs) in the MOB whe
80  monocultural plantings of nonnative plants, largely excluding native species from cropland.
81 cantly affect tertiary folding and appear to largely explain previously observed variations in hairpi
82 invasive community-associated MRSA rates was largely explained by socioeconomic factors.
83        Here we show that this variability is largely explained by the remote Atlantic multidecadal os
84                   Furthermore, these neurons largely express corticotrophin-releasing hormone or thyr
85  to identify driver mutations in cancer have largely focused on genes, whereas non-coding sequences r
86                      While previous work has largely focused on in vitro cellular models, here we dem
87 on and multimodel comparisons with data have largely focused on individual processes at subannual to
88                                  Assessments largely focused on national bans of specific pesticides
89                 However, this literature has largely focused on the effects of current family circums
90  CB intake on mouse hippocampal interneurons largely focusing on cholecystokinin-expressing interneur
91  applies, any octet expansion is now seen as largely formal, however, because the central element ess
92 ron emission tomography signal, which arises largely from microglial activation, and measures of subs
93                                  T2DM arises largely from obesity, poor diet, and lack of exercise, b
94                             However, we have largely ignored how the differentiation into the NKT cel
95 luene are major abundant dietary carotenoids largely ignored in the context of agro-food and health.
96                    Pathogenic Htt is present largely in a nonaggregated form at synapses, indicating
97                                     KCNQ1 is largely in an intracellular reservoir under basal condit
98 cell labeling showed Tac1-Pet1 soma resident largely in the caudal medulla.
99                  Changes in Nab3 binding are largely independent of alterations in transcription rate
100 t for determining drought tolerance, and are largely independent of wood density-a trait commonly ass
101 ing factors in earlier assessments that were largely indirect.
102                         We know that this is largely ineffective with resistance arising in most tumo
103                 The compaction reactions are largely insensitive to DNA torsional stress.
104  Even though this quantity is believed to be largely insensitive to nuclear structure and therefore t
105  While the plasma membrane proteome remained largely invariable, we observed pronounced alterations i
106       Although the atomic structure of T4 is largely known, the dynamics of its fascinating injection
107 nal microbiota of reproductive-aged women is largely made up of at least five different community sta
108 nversely, ectopic expression of Dmrt1 led to largely masculinized genetic females, production of Amh
109 he anticancer activities of these precursors largely match their self-assembling abilities.
110 pect to free triplets with an energy that is largely material independent ( approximately 30 meV).
111 tively fast evolution and have only a minor, largely modulatory role in gene regulation under diverse
112                                    Pain is a largely neglected symptom in patients with amyotrophic l
113 iolence victimization and later cognition is largely noncausal, in contrast to conventional interpret
114 nconventional path to access this previously largely obscure class of cyclooctatetraenyl radicals, wh
115 tral and claustrocortical connections remain largely obscure.
116 or the different conformations have remained largely obscure.
117    Morphologically, the enrichment consisted largely of planktonic cells with an average characterist
118 owever, past functional studies have focused largely on seed production; although useful, this focus
119    The urgency of the transition will depend largely on the country-specific prevalence of NNRTI resi
120 able properties of hydrogel particles depend largely on their size, and particles ranging from nanome
121 bre at the univariate level of analysis were largely overlapping.
122 al mnemonic operation that has thus far been largely overlooked in memory research.
123                    CO and longer-lived VOCs, largely overlooked in previous studies, extend the influ
124                                            A largely overlooked property of antibodies is their funct
125 hium transition-metal oxides (TMOs) has been largely overlooked.
126  of neuropil excitatory-inhibitory structure largely precedes dendritic arborization of primary motor
127   Conversely, CTCF binding sites in NPCs are largely preexisting in pluripotent stem cells.
128 nd P301S/E3 mice, whereas P301S/EKO mice are largely protected from these changes.
129 adiotherapy (n = 85), tracer sensitivity was largely PSA-independent.
130 visual metronome found their movements to be largely reactive, not predictive.
131 ptera, and it includes medium-size lacewings largely recognized by the presence of golden-colored eye
132                     Whereas establishment is largely related to event-level factors, apparently stoch
133 een based on the flow-limited assumption and largely rely on in vivo data for parametrization.
134 of these subpopulations to the injured brain largely remains unknown.
135 ent (Lep(ob/ob) ) mice and this phenotype is largely rescued by neonatal leptin treatments.
136 these results suggest that the microbiome is largely resistant to changes during sleep restriction.
137 sceptibility to bacterial infection and were largely resistant to endotoxin-induced septic shock.
138           Mechanistically, HDAC3 activity is largely responsible for histone deacetylation and inflam
139 eage and that English Thoroughbred sires are largely responsible for the predominance of this haploty
140 cells) and evening oscillators (E cells)-are largely responsible for these activity bursts.
141 t1's silencing effect on Foxa1 expression is largely responsible for Twist1-induced migration, invasi
142 der phase transformations with slow kinetics largely restricted by the nucleation and growth of a new
143      We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in m
144 that the intrinsically low activity of Ubc15 largely results from the presence of an acidic residue a
145 signals, finding that signaling dynamics are largely robust to interference.
146 thicker multiyear ice cover to a thinner and largely seasonal first-year ice cover with significant c
147 ptor activation, and activated receptors are largely sequestered from G proteins upon internalization
148 cuprate high-temperature superconductors are largely shaped by competing phases whose nature is often
149 ged to form an enclosed aqueous pore that is largely shielded from the membrane.
150 e that T cell responses to rDENV2Delta30 are largely similar to those to natural infection in terms o
151 ion varies widely between individuals but is largely stable over time within individuals [4, 5].
152                              This conclusion largely stems from polar research, with less attention p
153 f early jawless vertebrates, a role that was largely subsumed by vagal neural crest cells in early gn
154  lipids and show that these improvements are largely sustained in real data.
155             By proposing that the 1st Hit is largely telomere length-independent, while the 2nd Hit i
156 ding of the function of facilitation remains largely theoretical.
157 al array of firing fields, a pattern that is largely thought to reflect the operation of intrinsic se
158 mationally flexible molecules was determined largely through J-based configurational analysis, but ha
159 ere length-independent, while the 2nd Hit is largely TL-dependent, we resolve the paradox, highlighti
160 k bNAb binding to E2, and neutralization was largely toward the homologous genotype.
161 lated strain, USA300 also seems to have been largely unable to establish itself as an endemic infecti
162 at the overall pace of marsh development was largely unaffected by whether the upland being invaded w
163 l sensitivity whereas the fellow eye (FE) is largely unaffected.
164 e to genotype, and cell wall composition was largely unaffected.
165  TH 2 immunity as TH 1 and TH 17 immunity is largely unaffected.
166 ainly in native species (-19%), but remained largely unchanged in exotic species.
167 hile deep Southern Ocean temperature remains largely unchanged.
168 quences of disruption of this complex remain largely uncharacterized.
169  sites across the mammalian proteome, remain largely uncharacterized.
170 e ability of SCVs to resist host defenses is largely uncharacterized.
171 atial scales larger than single neurons, are largely uncharted.
172 uronal inflammation and degeneration remains largely unclear and presumably depends on the insult typ
173 endent genes during neuronal activity remain largely unclear.
174  fine-tuning double flower formation remains largely unclear.
175  surface receptors, including GPCRs, remains largely unclear.
176 ffected stem cells and somatic cells remains largely unclear.
177  of the vascular inflammatory state is still largely unclear.
178 nces repeatedly concludes that Americans are largely unconcerned about it.
179 utions travel easily and quickly, yet remain largely uncredited.
180  cues that position cells in this region are largely undefined.
181 cer cells, but the underlying mechanisms are largely undefined.
182 r; however, its role in tumor development is largely undefined.
183 ion Older patients with breast cancer remain largely underrepresented in cooperative group therapeuti
184 Once we understand emotion in simulation, we largely understand emotion in tragedy (and fiction).
185 larly conspicuous within angiosperms, but is largely unexplained.
186 vival of pelagic adults and juveniles remain largely unexplored and no study has simultaneously explo
187 d CpcA-PCB demonstrate the potential of this largely unexplored protein family as novel probes for su
188 breather solitons in microresonators remains largely unexplored, and its experimental characterizatio
189 m of lncRNA-mediated gene regulation remains largely unexplored, particularly in plants where their a
190 aintain systemic glucose homeostasis remains largely unexplored.
191 ogical functions of these proteins have been largely unexplored.
192 ith supramolecular host systems has remained largely unexplored.
193 ed, but their functional consequences remain largely unexplored.
194 tcome-specific conditioned inhibition remain largely unexplored.
195 ut the role of this region of the channel is largely unexplored.
196 ng with the retinal chromophore has remained largely unexplored.
197 cal determinants of viral persistence remain largely unexplored.
198  genetic programs underlying behavior remain largely unexplored.
199 ions in guiding structure formation is still largely unexplored.
200 s concerning the asymmetric hydrogenation of largely unfunctionalized olefins, from the first reports
201                    The microwave signals are largely uniform across grains and grain boundaries, sugg
202  should be considered failed trials that are largely uninformative and not eligible to be included in
203 tions of these imprinted genes have remained largely uninvestigated.
204  with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample
205 a (ACC) is an aggressive exocrine tumor with largely unknown biology.
206 cific physiological tau functions, which are largely unknown but could contribute to neuronal dysfunc
207 activated and other neurochemical content is largely unknown hence whether stimulus specific populati
208                         However, it is still largely unknown how gut dysbiosis affects the onset and
209 veryday hearing environment, it has remained largely unknown what neural mechanisms are used by the p
210                               However, it is largely unknown which genes and alleles adjust plant gro
211 tional regulation, and heterogeneity remains largely unknown, hampering their clinical use.
212 elective markers for MOB interneurons remain largely unknown, limiting mechanistic understanding of o
213 upereruption activity, or resurgence, remain largely unknown, limiting our ability to understand how
214 f Dlg4/PSD95, or other plasticity genes, are largely unknown, limiting the development of targeted ep
215 uishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised t
216  that specify human microglia phenotypes are largely unknown.
217 s and their impact on adult neurogenesis are largely unknown.
218 o orchestrate specific band activity remains largely unknown.
219 regulating these complex processes are still largely unknown.
220 onsible for mediating this protection remain largely unknown.
221 e pathogenic mechanisms of these viruses are largely unknown.
222  and beta cleavage of APP at synapses remain largely unknown.
223 properties of these heteromers have remained largely unknown.
224  and factors controlling MARCH5 activity are largely unknown.
225 eir composition, dynamics, and functions are largely unknown.
226 he mechanisms that permit this growth remain largely unknown.
227 ling outcomes through mechanisms that remain largely unknown.
228  various body patterns by the optic lobe are largely unknown.
229 tressors at local-to-regional scales remains largely unknown.
230  (miRs) regulate IOP and glaucoma in vivo is largely unknown.
231 , its tumorigenic function in MPNSTs remains largely unknown.
232 in and significance of these profiles remain largely unknown.
233 nd the dynamics of the gating components are largely unknown.
234 heir functions in SMC differentiation remain largely unknown.
235 ar mechanisms underlying this process remain largely unknown.
236           Its impact on glioblastoma remains largely unknown.
237 ction and regulation of these domains remain largely unknown.
238 However, its developmental mechanisms remain largely unknown.
239 hways contributing to these processes remain largely unknown.
240 gnaling changes in developing tissues remain largely unknown.
241 ilure (HF), but the outcome by type of AF is largely unknown.
242  and postoperative clinical outcomes remains largely unknown.
243 ow BRD4 is regulated in cancer cells remains largely unknown.
244  mitochondrial isoform of OGT (mOGT) remains largely unknown.
245 ganization of diverse thalamic nuclei remain largely unknown.
246 mice; however, the underlying mechanisms are largely unknown.
247 s long-term consequences on mortality remain largely unknown.
248 ty; however, its molecular mechanisms remain largely unknown.
249 g dependence-induced neuroadaptations remain largely unknown.
250 ally harmful action of apoptotic caspases is largely unknown.
251 echanisms of their function in complexes are largely unknown.
252 ver, how repair is initiated at telomeres is largely unknown.
253  the brain when taken as a drug of abuse are largely unknown.
254  characteristics are maintained afterward is largely unknown.
255 -containing proteins in human cancer remains largely unknown.
256 onsible for such adaptive homeostasis remain largely unknown.
257 e electron transfer in these systems remains largely unknown.
258  have adapted to this extreme environment is largely unknown.
259 the molecular steps of synaptogenesis remain largely unknown.
260 t its precise function and substrates remain largely unknown.
261 echanisms underlying acquired resistance are largely unknown.
262 a cells; however, its mechanism of action is largely unknown.
263 nd cardiovascular risk factors to LA size is largely unknown.
264 associated macrophage differentiation remain largely unknown.
265 ing urothelial formation and maintenance are largely unknown.
266 ributes to brain AD-type pathologies remains largely unknown.
267 critical for food and livelihood security is largely unknown.
268 mechanisms that result in this phenotype are largely unknown.
269 of a permanent expression of these genes are largely unknown.
270 talytically relevant protein motions remains largely unknown.
271 der in adults and children whose etiology is largely unknown.
272 ow McSCs respond to injury, however, remains largely unknown.
273 rial versus ventricular specification remain largely unknown.
274 tensive thalamocortical connectivity remains largely unknown.
275  affect MEK1 regulation and function remains largely unknown.
276 t of dead cells in the infarcted area remain largely unknown.
277  of neurons and ultimately brain circuits is largely unknown.
278 y are assembled to create the exosporium are largely unknown.
279 otrusions, but the underlying mechanisms are largely unknown.
280 dark-induced cytoskeletal arrangement remain largely unknown.
281 late the vasculature outside the CNS remains largely unknown.
282 e and regulate their expression profiles are largely unknown.
283 rinsic properties of this material are still largely unknown.
284 ical dendrite with further branches, remains largely unknown.
285 he mechanical behaviour of crustal rocks are largely unknown.
286  a normal brain into an epileptic one remain largely unknown.
287 he onset and progression of the syndrome are largely unknown.
288  properties and molecular identity are still largely unknown.
289 ractions with developmental programs, remain largely unknown.
290 utations prescribed by model-based RL remain largely unknown; however, multiple lines of evidence sug
291 is obscured by uncertainty arising from four largely unobserved processes: transmission, case observa
292           In addition, RSV's importance as a largely unrecognized pathogen of debilitated older peopl
293 d signaling through mechanisms that appeared largely unrelated to DJ-1 antioxidant activity.
294 grees C to 4.5 degrees C or greater -remains largely unscathed by the onslaught of new scientific ins
295  unactivated, hindered halides persists as a largely unsolved challenge in organic synthesis.
296                                      Nsg2 is largely unstudied.
297  sympathetic nerves, causes vasoconstriction largely via P2X1 receptors.
298  potential revenue from a food that is still largely wasted.
299 igated severe skin disease in a European and largely white study population.
300  studied electrophysiologically for decades, largely with ex vivo approaches that disrupt the photore

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