ライフサイエンスコーパス: last

1 temperatures and sea-ice cover spanning the last 1.5 million years (Ma) of orbitally-paced glacial

2 derwent high amplitude rhythmic fluctuations lasting 1-2 s in duration.

3 (sVEGF)-VEGF165, have been developed in the last 10 years to enhance cell survival, they showed limi

4 During the last 10 years, studies have mechanistically linked obesi

5 presented case, we describe that during the last 10 years, we have collected 28 cases of allergy to

6 nfants younger than 9 weeks, whereas a short-lasting (10-20 ms) central peak was observed for EMG-EMG

7 ine and terrestrial areas protected over the last 100 years have been colonized by any of the invader

8 er-annual timescale, we showed that over the last 110 years, volcanic eruptions have influenced ASM v

9 roughs, had at least 1 sexual partner in the last 12 months, stated willingness to take an STI test,

10 ving routine surveillance mammography in the last 12 months.

11 chemes, 8 figures and 528 references for the last 12 years and includes the description of the hydant

12 synthesis, covering the literature from the last 12 years.

13 Over the last 2 decades, research has unequivocally shown that ps

14 ging of neuroendocrine tumors (NETs) for the last 2 decades.

15 tive kidney injury) undergoing major surgery lasting 2 hours or longer under general anesthesia were

16 rate a genetic continuity in Europe over the last 20 millennia.

17 r CAA, in use in one form or another for the last 20 years, are now being reviewed to reflect these n

18 ndean orchid lineages only originated in the last 20-15 million yr.

19 t herbicide use intensity increased over the last 25 years in maize, cotton, rice and wheat.

20 throughout the winter mixed layer during the last 25 years.

21 rison of the 28-day baseline period with the last 28 days of a 24-week trial.

22 erated sorafenib (>/=400 mg/day for >/=20 of last 28 days of treatment), progressed on sorafenib, and

23 However, over the last 3 decades, improvements in intrauterine interventio

24 fined as a burst of systemic corticosteroids lasting 3 days or more.

25 tients received antineoplastic agents in the last 30 days of life throughout the study period.

26 zodiazepines (52.1% versus 26.6%) during the last 30 days of life, while diagnoses of opioid use diso

27 he greatest temperature increases during the last 30 years.

28 yosphere, geosphere, and atmosphere over the last 30,000 y that led to extensive changes in subseaflo

29 erved increase of AMPP-T and AMPT-P over the last 33 years is explained by eCO2 (39% and 42%) almost

30 he full rosters of invited speakers over the last 35 years for four prominent international virology

31 1910 to present levels-unprecedented in the last 363 years.

32 dic outbreaks of Ebola virus (EBOV) over the last 4 decades and the recent public health emergency in

33 substantially in the United States over the last 4 decades, driven largely by increases in papillary

34 tment period including at least three of the last 4 weeks.

35 ariation, and the rate of evolution over the last 40 million years.

36 incidence of positive rim cultures over the last 5 years of the analytic period compared with the fi

37 symptoms after a typical viral illness that lasted 5 days and had initially improved ("double-sicken

38 The massive use of fossil fuels during the last 50 years has generated a large CO2 concentration in

39 17 CPs, are persistent in sediments over the last 50-80 years, indicating that CPs are persistent che

40 At other times during the last 500 million years, particularly during the Cretaceo

41 the temperate Korean Peninsula (KP) for the last 5500 years in order to compare with Holocene millen

42 ions than men (total, 12.2 vs 17.6; first or last, 6.8 vs 10.7; P < .001 for both comparisons).

43 antic Oscillation (NAO), we show that in the last 60 years both high-frequency summer and spring NAO,

44 use or the number of sexual partners in the last 7 days, with high levels of consistent condom use w

45 Neurons can last a lifetime, but proteins turn over rapidly.

46 nts, delirium was diagnosed in 267 (17%) and lasted a median of 2 days (interquartile range, 1-5).

47 nd variable actions, and each syllable often lasts a few hundreds of milliseconds, making it difficul

48 heral macrophage infiltration initiates long-lasting adaptive immune responses after TBI.

49 mission hospitalization, but also portends a lasting, albeit attenuated, risk postreadmission.

50 vants is an important method to develop long-lasting and efficient vaccines against rabies.

51 provide the foundation for complete and long-lasting anti-influenza immunity.

52 administration 24 hour and 48 hour after the last AP challenge.

53 t no further whole-genome duplication in the last approximately 125 million years.

54 onsecutive months after stabilisation at the last assessed dose.

55 tidisciplinary medical follow-up expected to last at least 1 year that included an eye examination as

56 Significant increase in cortical activation lasting at least 3 years after GT was observed for all p

57 Early postnatal Mn exposure caused lasting attentional dysfunction due to impairments in at

58 Women had fewer total and first or last author publications than men (total, 12.2 vs 17.6;

59 the timing of the transition from first- to last-author publications.

60 o consecutive alpha-methylation steps on the last beta-keto intermediate to yield an alpha,alpha-gem-

61 a distinct, second conformation wherein the last beta-strand is retracted to extend the Ser65 loop a

62 quences of stressor exposure, including long-lasting biases towards habit-based responding in a food-

63 The effects of estrogen are long-lasting; bone marrow-derived macrophages from ovariectom

64 extension rates of c. 0.6 mm yr(-1) over the last c. 50 kyr in the eastern Sevier Desert are consiste

65 Sustained contacts result in long-lasting calcium activity and NFAT translocation, a measu

66 The last calculation assumes EUC dissolved iron concentratio

67 at has driven neuroscientific enquiry in the last century has been the nature of differences in the p

68 tensively bred for plumage traits during the last century, but the underlying genes are unknown.

69 savanna woody vegetation change spanning the last century.

70 ming of Arctic Ocean bottom water during the last century.

71 their breeding phenology by 5-12 d over the last century.

72 rways responses were measured 48 h after the last challenge.

73 similar to control groups 48 hour after the last challenge.

74 osed to serum, we demonstrate a dramatic and lasting change in phagocytic capacity after serum exposu

75 We show that iuGC-rats have long-lasting changes in cholinergic markers in the LDT, toget

76 rder, and (3) whether cannabis might produce lasting changes in the brain that increase the likelihoo

77 and ICAM-2 on B cells are essential for long-lasting cognate Tfh-B cell interactions and efficient se

78 blast traumatic brain injury (B-TBI) induced lasting cognitive impairments in novel object recognitio

79 -specific T44-KIR2DP1(F) encoded on CenB The last common ancestor of humans and chimpanzees had diver

80 ns managed to escape captivity and establish lasting communities, such as the Noir Marron.

81 Literature searches were last conducted in December 2016 in the PubMed database w

82 ability when abnormal experience could cause lasting damage to the developing brain.

83 Over the last decade 65% of our pediatric transplants were SLT.

84 Africa have sustained alarming losses in the last decade [1].

85 tion has witnessed tremendous success in the last decade after the introduction of cadaveric biologic

86 It is only in the last decade that sub-cellular resolution of red cell inv

87 ne viruses has become more apparent over the last decade, a deeper understanding of virus-host dynami

88 Within the last decade, a number of studies have documented visual

89 53 53 References 53 In the last decade, analyses of both molecular and morphologica

90 In the last decade, high-content screening based on multivariat

91 Over the last decade, numerous investigations have attempted to c

92 Over the last decade, our appreciation for the contribution of re

93 Over the last decade, remarkable progress has been made toward un

94 In the last decade, several large-scale transcriptome and inter

95 During the last decade, the development of improved and novel appro

96 ecules has made considerable progress in the last decade, though the disassembly processes remain und

97 terials (ENMs) has grown dramatically in the last decade, with increased use in consumer products, in

98 A has become increasingly important over the last decade.

99 reatitis (HTG-AP) increased rapidly over the last decade.

100 During the last decades major advances in understanding the adsorpt

101 has declined in sub-Saharan Africa over the last decades.

102 Strong and long-lasting declines were found for gymnosperms, shade- and

103 lesions to produce (1) a pronounced and long-lasting decrease of place field stability and (2) a stro

104 This causes a stimulus-specific and long-lasting deficit in the ability of the conditioned stimul

105 he Fennoscandian Ice Sheet at the end of the last deglaciation ( approximately 13,200-12,000 years ag

106 ately 1.4 m sea-level equivalent) during the last deglaciation, both of which have implications for i

107 imescales of decades to centuries during the last deglaciation, previously recognized only during the

108 was affected by external forcing during the last deglaciation, remains poorly understood.

109 ng hemispheric and global climate during the last deglaciation.

110 eep waters occurred synchronously during the last deglaciation.

111 sients in response to odors, triggering long lasting depolarization of olfactory glomeruli.

112 ne of the mysteries of memory is that it can last despite changes in the underlying synaptic architec

113 In these three patients, the last documented visual acuity on the Snellen eye chart b

114 eported the noninferiority 1 month after the last dose of 2-dose human papillomavirus 16/18 AS04-adju

115 he Dean scale was assessed 4 weeks after the last dose of chemotherapy by unblinded patient review of

116 ted with less hair loss at 4 weeks after the last dose of chemotherapy.

117 er among ED with recent alcohol consumption (last drink <10 days before enrollment) compared to those

118 1-4 days (n=14) or 24 days (n=1) after their last drink.

119 acoustic context has a large, rapid and long-lasting effect on a basic auditory judgement.

120 early adulthood, which illustrates the long-lasting effects of hydrogen on stress resilience in mice

121 2 y later, which was probably the result of lasting effects on acquired behaviors and dietary restra

122 However, the need for longer-lasting effects, combined with marked inter-individual v

123 n transcriptional programs, but also induces lasting epigenetic modifications in many target tissues.

124 Bivariable analyses (the 37 patients' last episodes) retained Sequential Organ-Failure Assessm

125 At the last evaluation (median 50.0 months [IQR 27.0-78.4]), 18

126 At last evaluation, 277 patients (91%) are alive at 62+/-13

127 On last examination, 64.41 +/- 6.76 months from presentatio

128 tion, time from disease onset until death or last examination, or age at death was collected for for

129 Time until disease onset or last examination, time from disease onset until death or

130 dal neurons: transient inhibition and longer-lasting excitation.

131 sense mutation c.796C>T (p.Arg266Ter) in the last exon of SERPINB7.

132 annels are a novel target to facilitate long-lasting extinction of alcohol-seeking behavior.SIGNIFICA

133 The last favours homochiral skyrmions, whose motion is drive

134 crete amygdalar CRF pathways modulate longer-lasting fear in anxiety- and trauma-related disorders.

135 The last few decades have seen substantial growth in the pop

136 been increasing at an alarming rate over the last few decades.

137 Despite slow progress in the field, the last few years have seen an explosion in our knowledge o

138 Over the last few years, several groups have evaluated the potent

139 n the treatment of malignant melanoma in the last few years, with these drugs now commonly used in cl

140 origin of tannins have been proposed in the last fifteen years, but are generally time consuming and

141 s potential thermoelectric materials for the last five decades, which offer paramount technological i

142 nt reported visiting an HCP about CeD in the last five years and the scores for all three validated i

143 disease (cGVHD) has come to fruition in the last five years, generating a clear understanding of a c

144 d tests, tumour characteristics, treatments, last follow-up date, and survival status-for patients di

145 followed until their first CHF event, death, last follow-up date, or December 31, 2011.

146 e-to-pregnancy cohort study (2008 to date of last follow-up in March 2016) of women (N = 981) aged 30

147 zed, and rate of strabismus and nystagmus at last follow-up visit were calculated.

148 fferent time points during the first and the last follow-up visits.

149 Death-censored graft survival at last follow-up was 100% in the ABOi and 98% in 50 compat

150 Resolution of symptom rate at last follow-up was 64% in the elderly group versus 86% i

151 Spherical regression at last follow-up was an average of +0.59 D.

152 November 1, 2012, and December 23, 2015; the last follow-up was performed on October 23, 2015.

153 At last follow-up, 87% of the surviving patients had no evi

154 m December 4, 2012, through August 28, 2016 (last follow-up, September 28, 2016).

155 At the date of the last follow-up, the differences in visual outcomes betwe

156 teins form activity-dependent complexes that last for around one second.

157 eat waves and mortality appeared acutely and lasted for 3 and 4 d.

158 cifically increased occurrence when flooding lasted for longer time periods, because large RAV reduce

159 0 years or younger with aphasia after stroke lasting for 6 months or more were recruited from 19 inpa

160 and purulent nasal discharge or facial pain lasting for at least 3 consecutive days, or worsening sy

161 cesses beginning with the initial insult and lasting for days, months and even years post-trauma.

162 y kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental protocols

163 hy different molecules are critical for long-lasting forms of LTP induced by diverse experimental pro

164 ia during a 4-year statewide extreme drought lasting from 2012 to 2015.

165 use earlier snow melt but may not change the last frost-free day of the year, plants that bud earlier

166 ficiency leads to telomere aberrations, long-lasting gammaH2AX and 53BP1 foci, and augmented cell dea

167 d-type and sub-cloned U2OS cells, except for lasting genomic differences between stable clones as rev

168 ique set of climate model simulations of the last glacial cycle (120 kyr), that compares well against

169 species probably colonized Abaco during the last glacial interval but were eliminated when the islan

170 o the eastern Ross Sea shelf edge during the Last Glacial Maximum (LGM) and eventually retreated 100

171 outh Georgia through the transition from the Last Glacial Maximum to Holocene.

172 Both tephra were erupted during the last glacial period and a widespread increase in subglac

173 atmospheric CO2 (Ca ) experienced during the last glacial period is hypothesized to have been an impo

174 ands, the Amazon was widely drier during the last glacial period, with much less recycling of water a

175 chronologies are only available for several Last Glacial pollen and rare speleothem archives princip

176 warmer, wetter, and more isolated during the last glacial-interglacial transition from approximately

177 again consistent with proxy evidence for the last glacial.

178 We conclude that the last glaciation of South Georgia was extensive, and the

179 ar fibrillation and ventricular tachycardia (lasting >/=30 seconds or recurrent symptomatic).

180 The last haemoglobin measurement was also negatively associa

181 alcitrant bladder infections without causing lasting harm to the urothelium.

182 e-mediated diseases and are known to reach a lasting homeostatic equilibrium following a dynamic prim

183 The transition from the last ice age to the present-day interglacial was interru

184 ulated the climate system's descent into the last ice age.

185 A literature search was conducted last in March 2017 in the PubMed and Cochrane Library da

186 CTDP-32476 alone produced a slow-onset, long-lasting increase in extracellular nucleus accumbens DA,

187 neuver through extracellular matrix and form lasting inflammatory microstructures.

188 pretreatment levels within 9 days after the last injection.

189 articular the terrace that formed during the last interglacial ( 125 ka) is found discontinuously alo

190 Recent studies argue that during the Last Interglacial (MIS 5e, approximately 128-116 ka) tro

191 ch attenuated toward the eMed, and also that last interglacial surface warming in the eMed was strong

192 The last interglaciation (LIG, 129 to 116 thousand years ago

193 cing such as exon circularization, first and last intron processing, alternative 5 and 3'ss usage and

194 The median follow-up for patients last known to be alive was 35.2 months (IQR 22.9-39.9).

195 se of a missing date of birth, diagnosis, or last known vital status.

196 ng behaviour in cases of self-reported fever lasting less than 3 days.

197 transmission was predicted to be higher and last longer at lower baseline transmission levels.

198 that Dhb modifications accumulate in a long-lasting manner in Shigella-infected cells, causing subse

199 However, the long-lasting mechanisms that shape risk or resilience for dru

200 (SIRs) for cancer were calculated after the last medical contact for urinary tract stones.

201 who started 3-drug ART regimens before their last menstrual period and did not switch or stop ART in

202 a rapid settlement of Madagascar during the last millennium.

203 ned estradiol/progesterone compared with the last month of leuprolide alone, the placebo month, and t

204 Both strategies lasted more than 500 mosquito generations (or about 40 y

205 ty score at postoperative month 1 and at the last noted clinic appointment.

206 on observed values (P = 0.044) but not using last observation-carried forward method.

207 Last, our study in humans supports a role for infection

208 Last, our study suggests diverse resistance mutations, w

209 ion Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-60

210 (first patient enrolled), to April 21, 2016 (last patient visit).

211 Such long-lasting patterning of habitats makes them ideal to test

212 Clinical status at last pediatric clinic visit prior to transfer was descri

213 The last phase coincided with rapid warming since 1985, and

214 arly-life immune activation can lead to long-lasting physiologic perturbations that resemble medical

215 hieved complete or partial response to their last platinum-based regimen, had a cancer antigen 125 co

216 lative abundances of Fusobacteria might have lasting positive effects on amphibian health.

217 ase progression within 36 months since their last previous therapy were enrolled.

218 pressing IL-7 improved the induction of long-lasting primary and secondary antibody responses post-RA

219 In the current study, we examined the long-lasting protective efficacy of chimeric VLPs (cVLPs) con

220 urgent need to develop single-dose and long-lasting rabies vaccines.

221 g GABA and p75(NTR) signaling fosters a long-lasting rearrangement of glutamatergic network that cont

222 ad follow-up assessments within 5 days after last receipt of study drugs with a mixed-effects model f

223 pathways, with the potential to induce long-lasting recovery of movement despite the continued absen

224 pectroscopic studies, we have identified the last redox event as being the turnover-limiting step of

225 vo or in vivo neural activity induced a long-lasting reduction in resting free astrocyte Ca(2+) and t

226 region in immature animals causes rapid and lasting reductions in glutamatergic transmission.

227 biopterin analogue, led to dramatic and long-lasting remission of depression.

228 ich resulted in a full and more than 6 years lasting remission of the disease.

229 Since our last report in 2014, we have added a large amount of dat

230 Since the last report published in the 2014 NAR Database Issue, IM

231 e Cys loop, through interactions between the last residue of post-M4 and Phe(170) of the conserved FP

232 rbugs," bacteria resistant to antibiotics of last resort.

233 Since this topic was last reviewed in The Lancet in 2012, advances in underst

234 Length of time since the last round of MDA and the prevalence of TF among childre

235 In the last several decades, efforts on understanding and contr

236 t prolonged or persistent effects, which can last several months, and exerts its effects by specifica

237 Using orthogonal partial last-squares discriminant analysis (OPLS-DA), multivaria

238 o a concentration of these components in the last stage of processing (vacuum concentration).

239 oefficients of independent predictors at the last step after checking for collinearity, likelihood ra

240 Fecal excretion of cholesterol is the last step in the atheroprotective reverse cholesterol tr

241 Lipoyl synthase (LipA) catalyzes the last step in the biosynthesis of the lipoyl cofactor, wh

242 Lysosomal membrane fusion mediates the last step of the autophagy and endocytosis pathways and

243 The last step of the sequence was modeled by DFT giving some

244 fluorination, introducing fluorine-18 in the last step of the synthesis, or by a building block appro

245 Krische allylation reaction established the last stereocenter, and the lactone moiety was formed by

246 Twenty-four hours following the last stressor, rats were bilaterally infused into the BN

247 st streams in southeastern Madagascar is the last survivor of a once dominant and widespread Mesozoic

248 Over the last ten years, isogenic tagging (IT) has revolutionised

249 s glaciers to climate variability during the last termination more significant than implied by previo

250 Last, the application of spheroid microarrays for sphero

251 And last, the mosaic melding employs an algorithm that globa

252 red a minimal CPC comprised of the dimerized last third of the kinase-activating Sli15/INCENP scaffol

253 Over the last three decades, mutations causing these disorders ha

254 as been on an extraordinary journey over the last three decades.

255 ines of therapy who were refractory to their last treatment.

256 VC) and followed up for at least 1 year from last treatment.

257 sentences were removed from the legend 'The last two calculations are discussed in the "Methods".

258 arch in this domain has rapidly grown in the last two decades and afforded many examples of bioinspir

259 field of flexible electronic devices in the last two decades and will certainly lead to a revolution

260 to lung cancer have been published over the last two decades but with few consensuses for the likely

261 c resonance imaging (fMRI) techniques in the last two decades have provided a tool to better understa

262 es in translational neuroimmunology over the last two decades have revolutionized the treatment of re

263 been regarded as "undruggable" targets, the last two decades have seen an increasing number of succe

264 The last two decades of network science have discovered stun

265 In the last two decades, a large body of evidence has reported

266 Over the last two decades, geogenic arsenic has emerged as a sign

267 o a major area of chemical research over the last two decades.

268 n the isolation of over 190 compounds in the last two decades.

269 ar events did not markedly decrease over the last two decades.

270 of their emissions at exhaust pipe over the last two decades.

271 he development of genomic resources over the last two decades.

272 The mutation removes the last two exons and part of the 3' UTR of DSTYK.

273 WAS) of responses to the question, 'Over the last two weeks, how often have you felt tired or had lit

274 ysed many different reactions already in the last universal common ancestor.

275 a carriage state can be established that can last up to a year or more.

276 East/Southern Africa, causing epidemics that lasted up to 28 years.

277 RI, producing unguided detailed descriptions lasting up to 40 min.

278 med in PubMed (Medline), Embase, and Scopus (last updated November 2016) to identify relevant publish

279 rapidly evolving, there is confidence in the lasting value of meetings for medical professionals.

280 lusters (roughly a 4-fold increase since the last version of the ATGC database), it is now built with

281 s per mL or premature discontinuations, with last viral load >/=50 copies per mL) cumulative through

282 urrence to cataract surgery, the time to the last visit of the follow-up, date of death, or the end o

283 At last visit, 6 of 27 (22%) patients had nystagmus and 12

284 At the last visit, the mean intraocular pressure for the tempor

285 Last, we determined that mOGT is probably involved in th

286 Last, we identified and studied three novel patient XIAP

287 Last, we pay special attention to the meiotic recombinat

288 Last, we show that some SNPs allosterically modulate PCS

289 Last, we will assess whether evidence exists in the lite

290 formed consent was provided according to the last will of the donors.

291 om data were available had seizures in their last year of follow-up, suggesting enduring seizure cont

292 15 patients, in the last year of life, and 4 carers under the care of commun

293 ug use disorders and mental disorders in the last year of life, though opioid use disorder diagnoses

294 of chronic noncancer pain conditions in the last year of life.

295 ctive asthma" (symptoms or medication in the last year, n = 744) were analyzed in this study to deter

296 ts or impurities has gained attention in the last years and is relevant to assess the safety of our c

297 The last years have also seen exciting advances in the chemi

298 nsiderable progress has been made during the last years in understanding the SnRK1 signaling pathway,

299 The clustering of illnesses in the last years of life is particularly pronounced in patient

300 reatment intensity has been reduced over the last years.