ライフサイエンスコーパス: late

1 ological processes has grown considerably of late.

2 an inactive chromatin state often responded late.

3 earch on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to bet

4 -Kishi (NHTK) reaction was discovered in the late 1970s and, since then, its main application has bee

5 ing levels of significantly less risk in the late 1990s.

6 o have sex with men have increased since the late 1990s.

7 European Masters dating from the 14th to the late 19th centuries were analyzed using synchrotron-base

8 f migration between 'early' (1993-2002) and 'late' (2004-2012) tagging periods.

9 ge was assessed across early (2000-2006) and late (2007-2012) periods.

10 by metal and will cover work published from late 2009 until mid-2016.

11 erg virus (SBV) was discovered in Germany in late 2011 and then spread rapidly to many European count

12 tic position of additional founding nests in late 2016 and early 2017.

13 by US Food and Drug Administration (FDA) in late 2016 and several other compounds are in advanced cl

14 rase 4 (PDE4) inhibitor, became available in late 2016 in the United States for mild-to-moderate AD,

15 ty would be 6%, a sixfold increase since the late 20th century.

16 ted landscape that survived intact until the late 20th century.

17 evere dry/heat spells causing dieback in the late 20th century.

18 onditions will be the most vulnerable in the late 21st century when climatic conditions will be analo

19 gned to receive SAP early (2798 patients) or late (2782 patients).

20 With a median follow-up of 3.3 years, the late (31-day to 5-year) benefit of CABG over PCI no long

21 nvestigate the clinical impact of additional late (68)Ga-PSMA-11 PET/CT.

22 On the other hand, late ablation of AnkG from established nodal complexes l

23 ults for carbonaceous chondrites reveal that late accretion, constrained to a maximum of 0.5 +/- 0.2

24 Recent reports have suggested the late actinides participate in more covalent interactions

25 I3 protein expression in mouse NK cells is a late activation event.

26 edian of 4.3 years posttransplantation) with late active ABMR and features of CP activation, such as

27 -sectional study of a school-based cohort in late adolescence (aged 18-19 years: The Tromso Study Fit

28 Late adolescence and young adulthood coincide with great

29 Late adolescence is a crucial, but underexplored, develo

30 and academic functioning was assessed during late adolescence.

31 changes of specific social brain regions in late adolescence.

32 dissection is associated with a high rate of late adverse events.

33 ving AF first diagnosed >7 days post-stroke (late AF) was highly associated with recurrent stroke/TIA

34 h, social or work functioning were not found late after injury.

35 strostomy feeding, age of seizure onset, and late age of diagnosis were independently associated with

36 of Alavatanais carabe and A. margulisae from Late Albian Penacerrada I amber (Spain) possess four pai

37 ation was observed for the two measures with late all-cause death.

38 rmine the time course of the early (EAR) and late allergic reaction (LAR).

39 Late AMD was found in 0.96% (95% CI, 0.59%-1.55%) of non

40 Mediterranean dietary pattern in those with late AMD, although it does not support previous reports

41 Prevalence of early and late AMD, BCVA, and number of AMD cases.

42 igns of AMD, 2209 had early AMD, and 150 had late AMD, of whom 104 had nvAMD.

43 Among the 1727 patients with late AMD, the mean (SD) age was 78.7 (7.4) years, and 66

44 Why do we go to sleep late and struggle to wake up on time?

45 remains poor because it is usually diagnosed late, and many efforts have been made to improve prevent

46 bnAbs appear very late, and patients are typically not protected by them.

47 Late antibody-mediated rejection (ABMR) is a leading cau

48 for the punctuated history of migrations in Late Antiquity.

49 moved into arsenic-rich environments in the late Archean Eon and Proterozoic Eon, respectively, by t

50 ent times occurring as early as 50 ms and as late as 400 ms after the phoneme onset.

51 y detecting Hoxa13 expression that early and late autopod progenitors fated for the wrist and phalang

52 mainly on missing, insufficient, or early or late baseline laboratory data.

53 the isoprenoid pathway, enzymes involved in late biosynthetic steps remain uncharacterized.

54 from the Pseudoalteromonadaceae only in the late-blooming phase, suggesting an active role of this g

55 as aberrant migration of both early-born and late-born neuroblasts, which could be linked to reduced

56 own-regulated miRNAs at the intermediate and late Braak stages of Alzheimer's disease (AD), as well a

57 like plasticity over M1 occurred only during late, but not early training.

58 n may serve as predictors for development of late cardiotoxicity.

59 surgeon volume, surgeon experience (early vs late career), and surgical specialization-categorized as

60 No volume effect was seen among late-career or specialty-trained surgeons.

61 During our studies on GpsB, a late cell division protein that controls activity of the

62 By late century, we found modest changes in the spatial dis

63 iated with greater anxiety/depression during late childhood.

64 kinetic groups: immediate-early, early, and late classes.

65 DFU-ISIs are important late complications of DFUs.

66 To assess in a mouse model whether early or late components of glucose metabolism, exemplified by fl

67 cted from both eyes of these patients at the late convalescent phase (30 days post-illness).

68 aurs were relatively common during the early Late Cretaceous.

69 gate the 5-year survival rates and causes of late death in this group of patients.

70 minated at the eastern coast of Greenland in late December, it was followed by a prolonged blocking p

71 tch" climate change in timing and pacing the Late Devonian mass extinction.

72 the extinction remain poorly constrained as Late Devonian stratigraphy is poorly resolved, compared

73 ue and were associated with higher counts of late differentiated CD8+ T cells.

74 ic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated T cells (CD8+CD28-CD45RA-).

75 e complete KO, this effect also included the late disease phase (8 h), indicating an important effect

76 Promisingly, NOD mice given transient late disease stage BAFFR-Fc monotherapy were rendered T1

77 season, and is followed by net abscission in late dry season that coincides with increasing leaf area

78 s during subsequent re-learning, and already late during initial acquisition.

79 ents disease, whereas augmenting the protein late, during adulthood, is devoid of benefit.

80 Greater levels of late/early ejection-phase MWS were associated with reduc

81 y malignant neoplasms (SPMs) is a well-known late effect after cancer, few studies have compared surv

82 They should also be prepared to manage late effects either directly or by referral to appropria

83 enetic modifiers to risk for the more common late effects of childhood cancer therapy.

84 care, including monitoring for long-term and late effects, and concerns regarding the effect of a can

85 rget muscle fibers over several hours during late embryogenesis, with episodic Ca(2+) signals present

86 ablated the major CLP gene Irf6 only in the late embryonic oral epithelium ( Irf6 cKO), bypassing th

87 A-seq to identify transcriptome changes from late embryonic to adult mouse muscle and demonstrate tha

88 Late endocytic compartments accumulate around Plasmodium

89 NF-kappaB proinflammatory signaling from the late endocytic pathway compartments in autoantibody gene

90 ansports TLRs from the early endosome to the late endolysosomal compartments.

91 rved the sequential recruitment of early and late endolysosomal markers to the elongating tPCs.

92 and CD1d proteins were retained in early and late endosomal compartments, respectively, supporting an

93 osomal Q-SNAREs and directly interacted with late endosomal SNARE complexes.

94 rt from the trans-Golgi network (TGN) to the late endosome/prevacuolar compartment (PVC) and for TGN

95 is, we observed that the recruitment of host late endosomes (LEs) and lysosomes is reduced in uis4(-)

96 rane-enclosed endocytotic organelles, mainly late endosomes (LEs).

97 A fraction of Stx3 is localized to late endosomes/lysosomes, although how it traffics there

98 410S at acidic pH, a reduced LDL delivery to late endosomes/lysosomes, and an increased release in th

99 R: 1.17, 95% CI: 1.07, 1.28), whereas higher late energy intake was significantly protective (HR: 0.9

100 higher hazards for mortality, whereas higher late energy intakes reduced mortality hazards.

101 A kappa value of 0.479 was found for late enhancement (P < .001), and the intraclass correlat

102 in greenhouse gas concentrations during the late Eocene to early Oligocene, and does not represent a

103 ooming bias was reflected in an asymmetry of late event-related potentials associated with motion eva

104 the role of keratinocyte gene expression in late events during the viral life cycle, RNA-Seq was car

105 Finally, to dissect early and late events following interspecific hybridization, we ex

106 rtioning sources of atmospheric particles in late fall in Innsbruck.

107 ng histone demethylase LSD1 in response to a late fed-state hormone, FGF19 (hFGF19, mFGF15).

108 Overexpression of COL12 causes late flowering specifically in long day conditions by de

109 egetative SAMs in ltm sp double mutants, and late flowering was partially suppressed, suggesting that

110 ious doming of vegetative SAMs combined with late flowering, as found in ltm plants.

111 mperatures in the previous year, and that of late-flowering plants primarily by temperatures 2 years

112 Expression of LanFTc1 in the ku (late-flowering) parent was strongly induced by vernaliza

113 tional repressor with early high general and late focused CNS expression.

114 ames and as a hyperfluorescent plaque in the late frame (late plaque).

115 turation of a second flagellar basal body in late G1 phase, DNA replication in S phase, and dimethyla

116 epolarization, electric markers of scar, and late gadolinium enhancement (all P<0.001).

117 Patients with late gadolinium enhancement (LGE) and low lateral MAPSE

118 rdiovascular magnetic resonance imaging with late gadolinium enhancement and a 24-hour Holter.

119 al role for electrocardiographic imaging and late gadolinium enhancement in early diagnosis and nonin

120 e of cardiac magnetic resonance imaging with late gadolinium enhancement in phenotyping the left vent

121 Only 1 patient presented with late gadolinium enhancement on cardiovascular magnetic r

122 with presence of a CMR diagnosis, extent of late gadolinium enhancement, and left and right ventricu

123 magnetic resonance (CMR) to assess LVEF and late gadolinium enhancement, indicative of ventricular f

124 77.8% (14/18) of patients had focal late gadolinium enhancement.

125 tor of 6-month wall thickening compared with late gadolinium enhancement.

126 PW-WPC protein and named here Upregulated in Late Gametocytes (ULG8), which we have leveraged to expr

127 tone PTMs are abundant during schizogony and late gametocytes; heterochromatic PTMs mark early gameto

128 abrogating postreplicative intermediate and late gene transcription.

129 teriophage that specifically transcribes its late genes, and thus represents a novel type of bacterio

130 We have shown that the proliferation of late gestation (embryonic day 19) fetal rat hepatocytes

131 MCH in late gestation promotes molecular maturation of the feta

132 1 in human choriodecidua and mouse uterus in late gestation.

133 There were no acute or late grade 5 toxic effects.

134 icantly improved graft function recovery and late graft function and reduced interstitial fibrosis af

135 iotropic effect on grain width (1.5%) during late grain development that determines the relative magn

136 ation, previously recognized only during the late Holocene.

137 ized that HIV-specific Ab responses regulate late IFN production.

138 RCA-bound origins initiating DNA replication late in S-phase.

139 However, late in the disease, excessive TH17 responses may be dis

140 present in the first year of life but emerge late in the first and into the second year.

141 produces Ca(2+) activation in the DN1 group late in the night.

142 -level vision: faces, scenes) and relatively late in visual development (starting at 4-5 years of age

143 This trial showed an IOP decrease after late in-the-bag IOL dislocation surgery that seemed to b

144 rval mimicking the rhythmicity of descending late indirect (I) waves in corticospinal neurons (4.3 ms

145 ng the CS, a pause, a rebound, and finally a late inhibition of SS activity for both zebrin positive

146 bosome resolve through relatively long-lived late intermediates wherein peptidyl-tRNA enters the P si

147 We found that early, and not late into skill training, CBI changed.

148 e observed that pUL31 is expressed with true late kinetics and is localized to nucleolin-containing n

149 dermal activation of Hox is initiated in the late larva prior to metamorphosis, in preparation for th

150 Some clusters increase in cell number during late larval stages, whereas others do not become DA posi

151 These genes, termed late-life cyclers, were also rhythmically induced in you

152 The etiologic factors of late-life depression are still poorly understood.

153 id pathology in this sample of patients with late-life depression.

154 diastolic dysfunction, and (2) initiation of late-life exercise training reverses age-related diastol

155 trate radical to the iron center followed by late ligand (Cl(-) or OH(-)) transfer to the substrate.

156 f lung cancer occurs 95% of the time due to late manifestation of its symptoms, necessitating rigoro

157 In normal cells, Ki-67 was a late marker of cell-cycle entry; Ki-67 mRNA oscillated w

158 stroke risk include HDP for ischemic stroke, late menopause and gestational hypertension for hemorrha

159 D-Zip transcription factor homologous to the LATE MERISTEM IDENTITY1 (LMI1) gene of Arabidopsis is th

160 ers, have an increased brain amyloid load at late middle age.

161 pollen feeding and/or pollination during the late Middle Jurassic, much earlier than the appearance o

162 The late Middle Palaeolithic (MP) settlement patterns in the

163 ike fossils, the oldest of which date to the Late Miocene, are exceedingly rare and likewise limited

164 ected near the O-M transition period and the late Miocene.

165 by APC/C(C)(dh1), but not APC/C(C)(dc20), in late mitosis and G1 phase.

166 y uncover an unexpected role for Aurora A in late mitosis.

167 aft vasculopathy (CAV) is the major cause of late mortality after heart transplant (HT), there is a n

168 Despite reductions in late mortality and the proportions of survivors with sev

169 In late mouse pregnancy, rhythmicity of energy metabolism-r

170 of Neandertals at open-air sites during the late MP reinforces the view that Neandertals were a resi

171 Instead, DRB reduces accumulation of gamma2 late mRNA in the cytoplasm.

172 1-3), is critical to the translation of HAdV late mRNA.

173 dPoxA is up-regulated and likely secreted at late multicellular development stages of D. discoideum w

174 operating characteristic curve for early and late multivariable models were 0.778 and 0.907, respecti

175 rticularly vulnerable brain compartment, the late myelinating superficial white matter.

176 tic region dating from the Mesolithic to the Late Neolithic and two samples spanning the Mesolithic-N

177 n dogs, contradicting a previously suggested Late Neolithic population replacement.

178 agriculture to Europe from Anatolia and the late Neolithic/Bronze Age migration from the Pontic-Casp

179 Early night, but not late night, sleep deprivation induced a significant phas

180 ht increase in G2/M, and cycle completion by late night.

181 ng the early night and advance it during the late night.

182 stant darkness and aroused in early night or late night.

183 nditions and valley network formation of the late Noachian.

184 k-based screening and early detection of key late-occurring or long-term complications using patient

185 of 22q11DS-related psychosis and control its late onset.

186 1524 patients with EOAD, 7046 patients with late-onset AD (LOAD), and 7001 cognitively intact contro

187 r models of AD and in patients with sporadic late-onset AD suggest that impaired mitophagy contribute

188 ene is the strongest genetic risk factor for late-onset AD.

189 Among individuals with impairing late-onset ADHD symptoms, the most common reason for dia

190 of the LT and Wnt pathways during early- or late-onset allergic airway inflammation and to address r

191 important contributing mechanism underlying late-onset Alzheimer's disease (LOAD).

192 in MAPKBP1 as a genetic cause of juvenile or late-onset and cilia-independent NPH.

193 "Difficult," "Early-onset mild atopic," and "Late-onset asthma." Children with moderate-to-severe ast

194 endogenous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuro

195 Three signals explained late-onset degradation: miR-430 seeds, AU-rich sequences

196 e of PD-ligands, both TS1 TEM and TN induced late-onset myocarditis.

197 set PE (EO-PE; symptom onset < 34 weeks) and late-onset PE (LO-PE; symptom onset > 34 weeks) cohorts.

198 6%) patients initially seen with an isolated late-onset seroma and 7 of 83 (8%) with an isolated new

199 ); "Early-onset mild non-atopic: (n = 153); "Late-onset" (n = 105); and "Exacerbation-prone asthma" (

200 ary atresia-like phenotypes and hepatitis in late organogenesis mouse embryos, but the molecular and

201 e associations of post-diagnosis obesity and late outcomes (>/=5 years after diagnosis) have been muc

202 gher risk of death at early (P = 0.0004) and late (P < 0.0001) time points.

203 bined with ambiguity in the relationships of late Palaeozoic actinopterygians, highlights this part o

204 previously thought, particularly when using late passages.

205 ase (r = 0.363, P = 0.03 one-tailed) and the late phase (r = 0.538, P = 0.004).

206 During the late phase of cardioprotection, antigen immunomodulatory

207 that MMP-3 inhibition or knock-out impaired late-phase LTP in the CA3-CA1 pathway.

208 ligase-inactive TRAF6[L74H] mutant, but the late-phase production of IL-6, IL-12, and TNFalpha (cont

209 Late-phase responses remained inhibited 7 months after t

210 d after intradermal allergen challenges, and late-phase responses were measured 4 and 7, 10, or 13 mo

211 ional brain activations during the early and late phases were compared with a longitudinal measure of

212 The late phenotype was only positively associated with aller

213 %] and early persistent [n = 67; 6.5%]), the late phenotype with onset at age 2 years or older (n = 5

214 a hyperfluorescent plaque in the late frame (late plaque).

215 ies of songbirds (Passeriformes) recorded as Late Pleistocene fossils on the Bahamian island of Abaco

216 associated with glacial terminations of the Late Pleistocene.

217 self-referential emotional reactivity (i.e., late positive potential) within the first second of view

218 nalyzed for voltage and abnormal (fragmented/late potential) electrogram characteristics.

219 coupled from the circadian clock, whereas in late pregnancy, energy availability is mediated by coord

220 During late pregnancy, female mice show no evidence of chronic

221 was quantified serially in early, mid-, and late pregnancy.

222 ng perturbed maternal insulin sensitivity in late pregnancy; hepatic insulin sensitivity was higher,

223 ic RNA interference (RNAi) in both early and late presentations.

224 spective cohort investigation of moderate to late preterm and term infants born at risk of hypoglycem

225 Moderate and late preterm children exhibited developmental delay comp

226 n pluripotent stem cell differentiation into late primordial germ cells, meiotic germ cells and ovari

227 gh future T1D risk can only be identified at late prodromal stages of disease indicated by markers su

228 iTE) antibody under the control of the major late promoter, leading to generation of ICOVIR-15K-cBiTE

229 We detected nuclear invagination channels at late prophase and telophase, potentially suggesting role

230 orresponding to the arrival of the early and late proteins at the plasma membrane.

231 at has completed enrollment and the other in late protocol development) will determine the clinical e

232 e-strand break repair correlated with severe late radiation toxicity.

233 observed for post-diagnosis BMI or WHR with late recurrence; a U-shaped association was observed for

234 The remaining 5 patients with late recurrent viremia had virologic relapse in which th

235 n 1 patient, the CD19(-) clone appeared as a late relapse 19 months after completion of blinatumomab

236 t a subset of origins, which primes them for late replication.

237 The reflex consists of early and late responses, mediated by Adelta and C fibers, respect

238 tion and exhibited an increased incidence of late rupture after nonreperfused infarction.

239 iming profiles from cells in early, mid, and late S phase of the mitotic cell cycle.

240 uggests that a maternal vaccine given in the late second or early third trimester of pregnancy would

241 auses a marked increase in both the peak and late sodium currents leading to prolongation of the acti

242 ential but markedly slowed repolarization of late spikes during repetitive firing; (ii) enhanced the

243 5 (71.4%) presented with early and late/very late ST, respectively.

244 ditions displayed the typical signature of a late stage biofilm, suggesting that biofilm formation is

245 use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natural produ

246 ze these substituted molecules, and enabling late stage functionalization of spiroligomer termini.

247 autophagy enhances viral replication at the late stage of infection, and the autophagy pathway facil

248 ristics typical of autophagosomes during the late stage of infection.

249 ster in a Y-tube olfactometer bioassay, at a late stage of infection.

250 ive regulation of extracellular proteases in late stage regeneration.

251 01), macro vascular invasion (P < 0.001) and late stage tumours (P < 0.001) had AFP over 400 ng/ml.

252 Cs by inducing their proliferation and, at a late stage, by modulating OPC maturation.

253 e prodrug Mipsagargin, which is currently in late-stage clinical trials for the treatment of cancer,

254 Late-stage diagnosis of lung cancer occurs 95% of the t

255 , or II), and 48 (51.6%) were diagnosed with late-stage disease (AJCC stage III or IV).

256 inhibition of tumor progression in early and late-stage disease.

257 methodology was successfully applied to the late-stage diversification of natural products and a mar

258 samicin classes of macrolide antibiotics via late-stage diversification.

259 d also works well for staining embryos, even late-stage embryos with cuticles, allowing characterizat

260 precise GNR heterojunctions prepared through late-stage functionalization of chevron GNRs obtained fr

261 e chemotypes described for the first time as late-stage gametocyte-targeting molecules.

262 under mildly basic conditions and enable the late-stage hydroxylation of several functionally-dense d

263 antiopure (S)-econazole and (R)-mirabegron a late-stage intermediate.

264 s used to detect and quantify atrophy due to late-stage non-neovascular and neovascular age-related m

265 ng through a Friedel-Crafts triflation and a late-stage oxidation of a furan ring.

266 EVs, distinguishing patients with early- and late-stage pancreatic cancer from healthy donors and pat

267 tor auris longus muscle from male and female late-stage R6/2 mice and age-matched wild-type controls.

268 ese PET tracers can be synthesised either by late-stage radiofluorination, introducing fluorine-18 in

269 f azole hemiaminals has been developed using late-stage structural modifications of the tert-leucinol

270 A late-stage TEMPO-mediated regioselective oxidation has b

271 ous membrane removal predominates during the late stages of cytokinesis, mediated by both dynamin and

272 hanges in the cytoskeleton at both early and late stages of infection.

273 ve site residues, which was installed in the late stages of laboratory evolution, apparently enhances

274 vation changes associated with the early and late stages of naive cell formation.

275 by a mean of 35% in early stance and 76% in late stance.

276 e demonstrate that Boi1/2 are required for a late step in the fusion of secretory vesicles with the p

277 In the late study phase, we provide evidence that MARV can be h

278 e network interactions between the early and late subsystems, and that the magnitude of the differenc

279 carotid arterial blood flow velocity during late systole and diastole.

280 Late systolic load has been shown to cause diastolic dys

281 protocol for postharvest storage of the very-late Tarocco "Sant'Alfio" orange to prolong the availabi

282 re the breakpoint (38/55 eyes [69%]), and as late tears if they tore afterward (17/55 eyes [31%]).

283 formed on the surface of microspores at the late tetrad stage, is hypothesized to play a key role.

284 ICOSL interactions were similarly crucial at late times for maintenance of the Tfh and GC B cells.

285 iques several hours post-PPCI, it may be too late to intervene at that time.

286 nal RT and was not associated with increased late toxicity.

287 The primary outcome measure was late toxicity.

288 ependent RNA polymerase and intermediate and late transcription factors provided evidence for a tempo

289 Diverse late transition metal catalysts convert terminal or inte

290 hich represents a new mode of reactivity for late-transition-metal chemistry.

291 Five late treatment failures were detected after AL and one s

292 for the clade Triadophlebiomorpha during the Late Triassic and expands its distribution and diversity

293 statistically significant increase in their late TTA group (odds ratio, 9.63; 95% CI, 1.08-86.17; P

294 mplications were significantly higher in the late versus early stent removal groups (36 of 126 [28.6%

295 6%) and 155 (71.4%) presented with early and late/very late ST, respectively.

296 Expression of multiple late viral protein mRNAs was lost in the presence of eit

297 odds ratios of complicated appendicitis for late vs early TTA across hospitals ranged from 0.39 to 9

298 age mean 32 weeks (early) and mean 37 weeks (late), we compared the fetal cerebral T2* in 28 fetuses

299 isplay a prolonged inflammatory phenotype in late wound healing.

300 ce with aging suppresses disease onset after late young adulthood in mice.