ライフサイエンスコーパス: late phase

1 dpi) (early phase) or at 15, 18, and 21 dpi (late phase).

2 transient with a fast early phase and a slow late phase.

3 dal vascular dilatations in both eyes in the late phase.

4 early phase and plasma and platelets in the late phase.

5 rly phase of the response and by SFKs in the late phase.

6 l nucleotide is specified-referred to as the late phase.

7 ermediate phase, and became extensive in the late phase.

8 Healing occurs in two phases, early and late phase.

9 ated kinase (ERK) activation, an early and a late phase.

10 regions depicted increased activation in the late phase.

11 ctor gene expression also reflects early and late phases.

12 F901318 is currently in late Phase 1 clinical trials, offering hope that the ant

13 enditure measured by indirect calorimetry in late phase (1,878 +/- 517 kcal) was significantly higher

14 rly phase (0-10 days; 4.1% of strokes) and a late phase (11-365 days; 4.3% of strokes).

15 production continued increase further in the late phase (16-24 hrs); whereas the production of PGD(2)

16 Ranolazine (5-10 mumol/L) eliminated late phase 3 EAD- and DAD-induced triggered activity as

17 preparations and the effect of ranolazine on late phase 3 early and delayed afterdepolarization (EAD

18 therapies as well as medications that are in late phase 3 trials or under approval exhibit primarily

19 tion, and fatty acid metabolism, whereas the late-phase 4-1BBL-mediated sustained inflammatory respon

20 early phase (8 h) and then decreases in the late phase (48 h).

21 ng ICU patients during acute phase (<= 5 d), late phase (6-10 d), and chronic phase (>= 11 d).

22 of the poor recovery of FBLN5 levels in the late phase (7 d) of healing in ovariectomized animals.

23 By contrast, in the late phase (72 h), when the NCX3 proteolytic cleavage ab

24 s required for the generation of ROS and the late-phase activation of JNK during TNF-induced necrosis

25 se in primary human macrophages and revealed late-phase activation of SREBP2, the master regulator of

26 NF-kappaB activity was elevated during late-phase activation, but the dimer composition was sti

27 active cells whose firing is correlated with late-phase active expiration.

28 spine loss rate was increased and during the late phase after denervation the spine loss rate was dec

29 ing the early phase and increased during the late phase after the lesion.

30 matic patients followed up from the early to late phase after TIA or stroke (339.7 nM vs 308.6 nM; p

31 ression of only CD152 was significant in the late phase after transplantation.

32 distinguish an early phase (1st week) and a late phase (after the 1st week), and (d) emphasize syste

33 [TCTP] and fortilin) has been implicated in late-phase allergic reactions (LPRs) and chronic allergi

34 e in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 swit

35 onsiveness, exercise-induced asthma, and the late-phase allergic response.

36 nto nasal mucosal tissue that results in the late-phase allergic response.

37 mRNA-specific DNAzyme attenuated early- and late-phase allergic responses to inhaled allergen.

38 thelial growth factor (VEGF) are features of late-phase allergic skin reactions, previously proposed

39 ransient activity of L4P at the start of the late phase and contributes to an efficient switch from e

40 zed that lactic acid (LA) contributes to the late phase and is not solely a consequence of bacterial

41 elease of inflammatory mediators, as well as late-phase and chronic allergic inflammation, resulting

42 pinal lamina IIo nociceptive synapses in the late phase, and this increase was suppressed by carbenox

43 ascular changes including capillary dropout, late-phase angiographic posterior and peripheral vascula

44 The early- and late-phase annual rates of endothelial cell loss were -8

45 g for superselective catheterisation whereas late phases are better for visualisation of tumour enhan

46 to neutrophil recruitment to injuries at the late phase as it induces Cxcl8 expression in vivo throug

47 -2 or c-PGES isomerase, mediates LPS-induced late-phase burst of PGE(2) generation, and regulates LPS

48 stimulation inhibits VAMP8-mediated mid- and late-phase but not VAMP2-mediated early-phase secretion.

49 mice showed blunted FcvarepsilonRI-dependent late-phase, but not acute, anaphylactic responses and ai

50 of life for persons with hemophilia, are in late-phase clinical development.

51 romising antibody-drug conjugates are now in late-phase clinical testing.

52 erapies for glioblastoma multiforme (GBM) in late-phase clinical trials has directed interest toward

53 Ruxolitinib is in late-phase clinical trials in essential thrombocythemia,

54 inical and translational data and early- and late-phase clinical trials in which palbociclib has been

55 alpha in cancer, including data from several late-phase clinical trials involving FRalpha-targeted th

56 a for promising agents that are currently in late-phase clinical trials, including daclizumab, ocreli

57 l findings into improved patient outcomes in late-phase clinical trials.

58 are numerous therapies that are currently in late-phase clinical trials.

59 d to the plasma membrane, where it recruited late-phase CME proteins and supported productive endocyt

60 entified distinct functions of early- versus late-phase corneal wound macrophages in corneal HA and L

61 jury-context dependent role of early- versus late-phase corneal wound macrophages with potential clin

62 as increasing focal hyperfluorescence in the late phase corresponding with RPE defects observed in FA

63 ed central hypofluorescence in the early and late phase, corresponding with areas of reduced flow in

64 st mite- and IL-33-driven lung inflammation, late phase cutaneous anaphylaxis, and collagen-induced a

65 ulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI

66 sponses in adaptive immune cell types, and a late phase (Day 90) by persistent elevation of neutrophi

67 imilar early induction kinetics but distinct late-phase declines.

68 reduced immediate hypothermia, as well as a late-phase decrease in body temperature that was abrogat

69 The late-phase decrease is associated with inhibition of T c

70 ral vessels, venous and arterial tortuosity, late-phase disc leakage, central and peripheral telangie

71 d D2R internalization in SZ leads to blunted late-phase displacement, or a faster return to baseline,

72 acy is the most common cause of attrition in late-phase drug development.

73 l inflammatory mediators, including IL-6, at late phase during the response to lipopolysaccharide cha

74 nervating corticospinal motor neurons; and a late phase during which growth-promoting factors are upr

75 d bilateral dilated, ectatic capillaries and late phase dye leak.

76 However, late-phase ear swelling, due to type III hypersensitivit

77 In mouse uteri, early- and late-phase estrogen-regulated gene responses were increa

78 ith right subthalamotomy could not engage in late phase, fast inhibition of the response and showed m

79 ations in the Early phase for snakes and the Late phase for monkey faces, but no significant differen

80 ion in which a key step is the activation of late-phase gene expression to produce proteins from whic

81 -regulated kinase 1/2 activation and not the late phase generally associated with beta-arrestin recru

82 A subset of late phase genes was expressed in rheumatoid arthritis s

83 Expression of a subset of late phase genes was mediated by autocrine IL-10, which

84 IL-10-STAT3 autocrine loop and expression of late phase genes.

85 otid stenosis in the early (</= 4 weeks) and late phases (>/= 3 months) after TIA or stroke in this p

86 PFC inactivation deteriorated the quality of late-phase (>150 ms from image onset) IT population code

87 zard ratio [HR]: 1.24; p = 0.04) and reduced late-phase hazard of death (HR: 0.57; p = 0.04) than the

88 s canicula (a representative chondrichthyan) late phase HoxD transcripts are present in cells of the

89 Here we used 'late-phase' imaging after challenge to test the hypothes

90 ge, yet the mechanisms by which the mosquito late-phase immune response limits oocyst survival are le

91 ete-to-oocyst differentiation but mediates a late-phase immune response that decreases oocyst surviva

92 ting hemocytes as critical modulators of the late-phase immune response.

93 1), and (iv) MALDI-TOF MS identification and late phase implementation of TLA (TLA2).

94 g responses and formalin-induced pain in the late phase in mice.

95 scein angiography showed staining during the late phase in the central macula at all follow-up visits

96 tial phase and that they express LAG3 in the late phase in the experimental autoimmune encephalomyeli

97 The late phase includes responses related to phagocytosis by

98 ge and within an area of hypofluorescence on late-phase indocyanine green angiographic images.

99 angioid streaks and reduced fluorescence on late-phase indocyanine green angiography, prompted genet

100 y significantly exacerbates the IgE-mediated late phase inflammation in a murine model of passive cut

101 However, the late phase inflammatory pain following complete Freund's

102 The late-phase inhibition of T cell activation is, in part,

103 ated postprandial glucose despite 14% higher late-phase insulin) without change in early-phase insuli

104 ease of luminal Ca(2+) and unevenly inhibits late-phase intracellular Ca(2+) mobilization.

105 Sulindac induced iNOS and Hsp70, late-phase IPC markers in the RPE cells.

106 the repressive effect of IL-1beta during the late phase is mediated through Sp3 recruitment to the pr

107 ed graft rejection could be the cause of the late-phase islet loss.

108 Third, these behaviorally critical late-phase IT response patterns were poorly predicted by

109 During the late phase, LCs and macrophage numbers transiently incre

110 Using late phase long-term potentiation (L-LTP) in the hippoca

111 ndent BDNF expression impairs BDNF-dependent late-phase long-term potentiation (L-LTP) in CA1, a site

112 f basophils failed to develop early (EPR) or late phase (LPR) nasal responses following allergen sens

113 hods were used to evoke and record early and late phase LTP in the dentate gyrus of anesthetized rats

114 ressed early phase LTP without affecting the late phase LTP of dentate gyrus.

115 that MMP-3 inhibition or knock-out impaired late-phase LTP in the CA3-CA1 pathway.

116 a modest decrease in the ability to maintain late-phase LTP induced by three trains of TS.

117 Interestingly, late-phase LTP was also decreased by MMP-9 blockade.

118 -3 and MMP-9 were inhibited, both early- and late-phase LTP was impaired.

119 decaying (early-phase) LTP and nondecaying (late-phase) LTP.

120 d its correlation with early (tryptase)- and late-phase markers (IL-13 levels, eosinophil numbers) of

121 those with chronic/recurring symptoms in the late phase (mean follow-up, 11 years) did have higher ri

122 vioural responses: early-phase analgesia and late-phase mechanical allodynia which requires NMDAR; bo

123 Comparing initial with late phase, median VDP of all subjects decreased from 49

124 process with an increase during middle- and late-phase meiosis.

125 role for dorsal hippocampal dopamine in this late-phase memory consolidation and, unexpectedly, diffe

126 Late-phase microangiography was used to detect trunk lym

127 and larval zebrafish can be quantified using late-phase microangiography.

128 ) overwhelmed initial killing, and a second, late-phase microbicidal response killed viable bacteria

129 myocardial injection of autologous CSCs in a late phase model of chronic infarction resulted in less

130 ad of the IRAK2-TRAF6 interaction to sustain late-phase mRNA production.

131 complete Freund's adjuvant injection and the late phase neuropathic pain following chronic constricti

132 ng Nox4 demonstrated a substantially reduced late-phase neuropathic pain behavior after peripheral ne

133 jury could upregulate connexin-43 to sustain late-phase neuropathic pain by releasing chemokine from

134 lowing lumbar puncture alleviates early- and late-phase neuropathic pain symptoms, such as allodynia

135 mechanical allodynia, a cardinal feature of late-phase neuropathic pain.

136 release of astrocytic mediators and sustain late-phase neuropathic pain.

137 vity that drove exaggerated transcription of late-phase nuclear factor-kappaB response genes in vitro

138 However, as infection proceeds to the late phase, nucleosomes redistribute extensively to esta

139 of feeding in INT-BDNF(-/-) mice during the late phase of a scheduled meal suggested that increased

140 eading to elevated calcium levels during the late phase of a subsequent excitatory stimulus.

141 and shows elevated calcium levels during the late phase of a subsequent excitatory stimulus.

142 The late phase of adenovirus gene expression is controlled b

143 nt activation of the L4P at the onset of the late phase of adenovirus gene expression.

144 ase of ADO effect only in 12 PVs, during the late phase of ADO effect only in 8 PVs, and during both

145 t checkpoints of the FoxP3 Treg chain in the late phase of alloimmune response and, thus, acts as an

146 nal-regulating kinase 1 (ASK1) regulates the late phase of APAP-induced JNK activation, but the mitog

147 pathway was required for both the early and late phase of Arc translation during mGluR-LTD, through

148 The late phase of bacterial killing required both caspase-in

149 level of BAX recruited to the MOM during the late phase of BAX recruitment.

150 During the late phase of cardioprotection, antigen immunomodulatory

151 luding survival in macrophages or during the late phase of chronic tuberculosis in the murine lungs.

152 and Hsp90beta play an essential role in the late phase of CLC-1 quality control by dynamically coord

153 osA and AfuvelB expression during the mid to late phase of conidiation.

154 Hippocampal dopamine promotes the late phase of consolidation of an aversive step-down avo

155 mplicating cAMP signaling by PDE4B in a very late phase of consolidation.

156 together, these findings describe a distinct late phase of corneal allograft rejection that is likely

157 on null STAT-3 mutant led to the loss of the late phase of cyclin D1 expression.

158 reatment with fingolimod (FTY720) during the late phase of disease revealed that retinal CD8(+) T cel

159 ssion into an early phase of induction and a late phase of down-regulation.

160 dult Ixodes ricinus females during early and late phase of engorgement.

161 Myosin VI knockdown selectively impaired a late phase of exocytosis, consistent with a replenishmen

162 ion without leakage or pooling of dye in the late phase of FA.

163 0-kDa auxiliary protein produced in the very late phase of gene transcription by Autographa californi

164 Finally, a late phase of geochemical modification by saline fluids

165 d kinetics (4-6 hours), establishing a novel late phase of GF signaling that appears to be constituti

166 Late phase of healing occurs a few days postinjury and i

167 impaired both long-term memory (LTM) and the late phase of hippocampal long-term potentiation (L-LTP)

168 rability of IN to small molecules during the late phase of HIV-1 replication unveils a pharmacologica

169 ncy is unexpectedly accounted for during the late phase of HIV-1 replication.

170 n coassemble with HIV-1 Gag and modulate the late phase of HIV-1 replication.

171 A late phase of HoxD activation is crucial for the pattern

172 ratio at early and intermediate phases, not late phase of hypoxic-ischemic group.

173 y, whereas stimulation of autosis during the late phase of I/R with Tat-Beclin 1 exacerbated injury.

174 CH2 interacted directly with NEMO during the late phase of infection and catalyzed K-48-linked ubiqui

175 nt for the temporal switch from the early to late phase of infection by regulating both early and lat

176 immune modulation occurs during the early or late phase of infection, assessments of fungal burden an

177 At late phase of infection, enhanced bacterial counts in PF

178 and how it contributes to activation of the late phase of infection, is important to our understandi

179 mmation, coagulation, and homeostasis in the late phase of infection, resulting in a more severe dise

180 ene expression was down-regulated during the late phase of infection, which led to relocation of the

181 per transition of gene expression during the late phase of infection.

182 d after reaching their peak expansion in the late phase of infection.

183 ngs of asthmatics may be responsible for the late phase of inflammatory asthma.

184 II expressed in the motor neuron blocked the late phase of intermediate-term facilitation in sensory-

185 peak generation of which coincided with the late phase of killing.

186 The late phase of long-term potentiation (LTP) at glutamater

187 excitability of neurons and facilitates the late phase of long-term potentiation (LTP) in the Schaff

188 es protein synthesis required to sustain the late phase of long-term potentiation (LTP).

189 ated with the regulation of COX-2 during the late phase of LPS activation in macrophages.

190 eting TLR4 signaling, was induced during the late phase of lung injury in WT mice, whereas it was inc

191 In the late phase of M1 macrophage polarization, increased hist

192 emerging response properties, followed by a late phase of permissive maturation, when sensory-driven

193 f IR and subsequently replenished during the late phase of post-IR genome reassembly.

194 virus, UL103 appears to function during the late phase of replication, playing a critical role in eg

195 lted in the inhibition of both the early and late phase of ROS generation, without affecting the earl

196 onstrate that Cdc7 regulates the initial and late phase of SM differentiation through distinct mechan

197 We find ERG mediates the late phase of spike-frequency adaptation in pyramidal ce

198 associated with a high mortality during the late phase of the acute hospital stay.

199 During the late phase of the HIV-1 replication cycle, the viral Gag

200 indicating that the stroma helps control the late phase of the HPV life cycle in the epithelium.

201 l for sustained T cell activation during the late phase of the immune response.

202 During the late phase of the large West-African Ebola virus disease

203 e other, phage DNA movement slows during the late phase of the lytic cycle, whereas it remains the sa

204 ut the train of 10 stimuli and dominated the late phase of the train EPSC.

205 However, knockdown of Src abolished the late phase of TLR3 Tyr-759 phosphorylation and decreased

206 lls have difficulty distinguishing early and late phases of a transcriptional cascade or identifying

207 While it is clear that the late phases of adipocyte maturation are governed by the

208 ect only in 8 PVs, and during both early and late phases of ADO effect in 8 PVs.

209 lays critical but diverse roles in early and late phases of antibody responses and plasma cell differ

210 lly preceded dynamin2 recruitment during the late phases of CME, and promoted dynamin recruitment.

211 al cycle inhibitors on immediate, early, and late phases of cone photopic vision.

212 elopment comprises the coupling of early and late phases of conserved gene expression.

213 t not ROCK, markedly reduced the initial and late phases of contraction in a non-additive manner and

214 ific antagonist reduced both the initial and late phases of contraction with a significant decrease i

215 We hypothesized that cells in late phases of differentiation would be selectively less

216 demonstrate a dissociation between early and late phases of encoding processes.

217 strated the role of EhRab35 in the early and late phases of erythrophagocytosis by the amoeba.

218 nscriptional plasticity during the early and late phases of ET at single-cell resolution.

219 nt were unaltered, Slc7a5 knockdown effected late phases of GC dendrite maturation and survival.

220 L-6, two key IL-22 inducers in the early and late phases of infection, respectively.

221 ne expression shows that there are early and late phases of infection.

222 w-titer anti-WNV antibodies during early and late phases of infection.

223 d with biological processes in the early and late phases of ischemia-reperfusion injury.

224 with the retromer complex at both early and late phases of macropinosome maturation, but mediates re

225 phase, whereas CXCL8 plays a key role in the late phases of recruitment, but the crosstalks between t

226 sequent trafficking steps, such as early and late phases of recycling of AT1-R in human embryonic kid

227 s that display defects during both early and late phases of retinal neurogenesis.

228 target for the management of both early and late phases of severe SAg-mediated illnesses.

229 P3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respective

230 a novel and major regulator of FOXO1 in the late phases of the cell cycle.

231 the role of mast cells in both the early and late phases of the inflammatory response in experimental

232 on of formalin-induced behavior in early and late phases of the mouse intradermal formalin test of pa

233 f ROS and hormone signaling during early and late phases of the plant response to abiotic stress, the

234 nown functions of UPF3B during the early and late phases of translation termination suggest that UPF3

235 ndicating progression into the late and very late phases of viral infection.

236 In mouse limbs the autopod is built by a "late" phase of Hoxd and Hoxa gene expression, orchestrat

237 The persistent or "late" phase of long-term potentiation (L-LTP), which req

238 of a wide range of durations; by minimizing late phase oscillations response durations may be fine-t

239 t do not correlate with other immediate- and late-phase parameters.

240 the formation of new stable synapses during late-phase plasticity.

241 te phase, and extensive neuronal loss in the late phase postreoxygenation.

242 UMO-2 from Mre11 and Nbs1, indicating that a late-phase process is involved in Mre11 and Nbs1 desumoy

243 ligase-inactive TRAF6[L74H] mutant, but the late-phase production of IL-6, IL-12, and TNFalpha (cont

244 rse outcome, patients with AHF have a better late phase prognosis compared with patients with Cr-HF (

245 ase (r = 0.363, P = 0.03 one-tailed) and the late phase (r = 0.538, P = 0.004).

246 enters (RCs), DNA-PK is later distanced from late-phase RCs.

247 at the level of the conjunctiva reflects the late-phase reaction.

248 T cells accumulate in patients with allergic late-phase reactions (LPRs).

249 asma NPY and increase in platelet NPY during late-phase recovery.

250 results suggest a considerable deficiency in late-phase replication and viral assembly during VZV inf

251 tential duration lengthening occurred during late-phase repolarization resulting in triangulation (70

252 phosphorylated in a biphasic manner, and the late phase requires NFATc1-mediated p300-dependent acety

253 LCs), whereas IL-6 administration during the late phase rescued IL-22-mediated production from CD4(+)

254 ncreases memory when applied at the early or late phases, respectively.

255 ts reveal an mTORC1-dependent IL-10-mediated late phase response to TNF by primary human macrophages,

256 erapy (SCIT) using the allergen-induced skin late-phase response (LPR) and exploratory immune monitor

257 AQX-1125 significantly attenuated the late-phase response compared with placebo (FEV1 4-10 h:

258 ild-to-moderate asthmatics with a documented late-phase response to inhaled allergen (LAR).

259 onse, EPR) and 24 h after the 6th challenge (late-phase response, LPR).

260 exerts negative regulation over IgE-induced late phase responses and cytokine production in mast cel

261 om older donors have diminished induction of late-phase responses (eg, STAT1, IRF7, and IRF1), sugges

262 ermal allergen immunotherapy suppressed skin late-phase responses but was not clinically effective an

263 ection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcut

264 essed by bronchoalveolar lavage (BAL) during late-phase responses following allergen challenge of all

265 Late-phase responses remained inhibited 7 months after t

266 ly, fingolimod attenuates both immediate and late-phase responses to histamine with reduced extravasa

267 e that basophil activation during early- and late-phase responses to inhaled allergen might be driven

268 es predominated early on in response to LCS, late-phase responses were characterized by up- and downr

269 d after intradermal allergen challenges, and late-phase responses were measured 4 and 7, 10, or 13 mo

270 Furthermore, early and late phases resulting from allergen exposure were shown

271 mediator of translation initiation block in late-phase sepsis.

272 immune system surveillance, whereas, in the late phases, shigellae harboring immunopotent LPS are fu

273 Only the late phase showed significant correlations with perceptu

274 e allergen-specific T cells, they may reduce late-phase side-effects during SIT.

275 olarization and ACh release leads to reduced late phase spike-frequency adaptation and persistent fir

276 rvation spine density decreases and during a late phase spine density recovers again.

277 DNF synthesis is required for spine pruning, late-phase spine maturation, and recovery of cortical re

278 efficiency, and thus more applicability for late-phase studies, or greater statistical efficiency bu

279 ver, unlike with PCA responses, there was no late-phase swelling.

280 There was an increase in early and late-phase symptoms after every allergen challenge compa

281 emonstrated that their absence resulted in a late phase that is associated with enhanced neutrophil i

282 s spread over most of the imaged area, and a late phase that was spatially confined.

283 ing stathmin-tubulin binding, whereas in the late phase these processes are reversed leading to an in

284 al roles in moving the infection on into the late phase; these two proteins are produced by the actio

285 wever, during the masseteric pain challenge (late phase), TMD patients exhibited significant reductio

286 ilitate the transition of these therapies to late phase trials and to evaluate closely histocompatibi

287 disease and may not translate to patients in late-phase trials and practice.

288 e, a (99m)Tc-labeled folate conjugate, is in late-phase trials in Europe and the United States.

289 cose-avid lymphomas in clinical practice and late-phase trials.

290 mission and maintain neuropathic pain in the late-phase via releasing chemokines.

291 however, the deletion of QTQTN may restrict late-phase viral replication.

292 ibutes to an efficient switch from early- to late-phase virus gene expression.

293 acy for acute phase was Swinamer (1990), for late phase was Brandi (1999) and Swinamer (1990), and fo

294 seconds (P = .002) and significantly reduced late-phase washout slope (P = .002) when compared with h

295 slope of the first-pass peak (P = .011), and late-phase washout slope (P = .032), estimated by using

296 (HR, 4.38 [95% CI, 1.39-13.81]), and in the late phase were nonmyeloablative conditioning regimen (H

297 ional brain activations during the early and late phases were compared with a longitudinal measure of

298 th PG-PS developed increased fibrosis in the late phase, whereas control rats did not.

299 Finally, downstream factors derived from the late phase, which do not include Oct4, Sox2, Klf4, c-Myc

300 ession of injury-mediated corneal HA and LA, late-phase wound macrophages control maintenance of esta