ライフサイエンスコーパス: late phase

1 dpi) (early phase) or at 15, 18, and 21 dpi (late phase).

2 fibrosis starting 14 days after laparotomy (late phase).

3 crete cytokines/chemokines and leukotrienes (late phase).

4 early phase and plasma and platelets in the late phase.

5 rly phase of the response and by SFKs in the late phase.

6 regions depicted increased activation in the late phase.

7 l nucleotide is specified-referred to as the late phase.

8 ermediate phase, and became extensive in the late phase.

9 Healing occurs in two phases, early and late phase.

10 f disease progression, without affecting the late phase.

11 transient with a fast early phase and a slow late phase.

12 ated kinase (ERK) activation, an early and a late phase.

13 ctor gene expression also reflects early and late phases.

14 F901318 is currently in late Phase 1 clinical trials, offering hope that the ant

15 rly phase (0-10 days; 4.1% of strokes) and a late phase (11-365 days; 4.3% of strokes).

16 production continued increase further in the late phase (16-24 hrs); whereas the production of PGD(2)

17 Ranolazine (5-10 mumol/L) eliminated late phase 3 EAD- and DAD-induced triggered activity as

18 preparations and the effect of ranolazine on late phase 3 early and delayed afterdepolarization (EAD

19 therapies as well as medications that are in late phase 3 trials or under approval exhibit primarily

20 early phase (8 h) and then decreases in the late phase (48 h).

21 By contrast, in the late phase (72 h), when the NCX3 proteolytic cleavage ab

22 s required for the generation of ROS and the late-phase activation of JNK during TNF-induced necrosis

23 NF-kappaB activity was elevated during late-phase activation, but the dimer composition was sti

24 active cells whose firing is correlated with late-phase active expiration.

25 spine loss rate was increased and during the late phase after denervation the spine loss rate was dec

26 Here we report that p53 stabilization in the late phase after ionizing radiation correlates with acti

27 ing the early phase and increased during the late phase after the lesion.

28 matic patients followed up from the early to late phase after TIA or stroke (339.7 nM vs 308.6 nM; p

29 ression of only CD152 was significant in the late phase after transplantation.

30 of the early phase (0-2 h), and blunted the late phase (after 4 h) of JNK activation and translocati

31 distinguish an early phase (1st week) and a late phase (after the 1st week), and (d) emphasize syste

32 However, late-phase allergic conjunctivitis in NKT cell-depleted,

33 [TCTP] and fortilin) has been implicated in late-phase allergic reactions (LPRs) and chronic allergi

34 e in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 swit

35 onsiveness, exercise-induced asthma, and the late-phase allergic response.

36 nto nasal mucosal tissue that results in the late-phase allergic response.

37 mRNA-specific DNAzyme attenuated early- and late-phase allergic responses to inhaled allergen.

38 thelial growth factor (VEGF) are features of late-phase allergic skin reactions, previously proposed

39 ransient activity of L4P at the start of the late phase and contributes to an efficient switch from e

40 elease of inflammatory mediators, as well as late-phase and chronic allergic inflammation, resulting

41 pinal lamina IIo nociceptive synapses in the late phase, and this increase was suppressed by carbenox

42 The early- and late-phase annual rates of endothelial cell loss were -8

43 to neutrophil recruitment to injuries at the late phase as it induces Cxcl8 expression in vivo throug

44 mutant's growth dropped slightly during the late phase at 37 degrees C.

45 and 7) significantly blocks antigen-induced late-phase bronchoconstriction and airway hyper-responsi

46 -2 or c-PGES isomerase, mediates LPS-induced late-phase burst of PGE(2) generation, and regulates LPS

47 stimulation inhibits VAMP8-mediated mid- and late-phase but not VAMP2-mediated early-phase secretion.

48 mice showed blunted FcvarepsilonRI-dependent late-phase, but not acute, anaphylactic responses and ai

49 aB-dependent and necessary for the resulting late phase cardioprotection against a subsequent ischemi

50 canakinumab, have shown promise in early and late phase clinical trials.

51 of life for persons with hemophilia, are in late-phase clinical development.

52 romising antibody-drug conjugates are now in late-phase clinical testing.

53 Ruxolitinib is in late-phase clinical trials in essential thrombocythemia,

54 inical and translational data and early- and late-phase clinical trials in which palbociclib has been

55 a for promising agents that are currently in late-phase clinical trials, including daclizumab, ocreli

56 are numerous therapies that are currently in late-phase clinical trials.

57 d to the plasma membrane, where it recruited late-phase CME proteins and supported productive endocyt

58 st mite- and IL-33-driven lung inflammation, late phase cutaneous anaphylaxis, and collagen-induced a

59 ulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI

60 he early phase (day 1 postinfection) and the late phase (day 2 postinfection) of the type I IFN respo

61 imilar early induction kinetics but distinct late-phase declines.

62 reduced immediate hypothermia, as well as a late-phase decrease in body temperature that was abrogat

63 The late-phase decrease is associated with inhibition of T c

64 ral vessels, venous and arterial tortuosity, late-phase disc leakage, central and peripheral telangie

65 itiation, whereas Tregs reciprocally inhibit late-phase disease, with overlapping B10 cell and Treg f

66 hich paralleled their negative regulation of late-phase disease.

67 athogenesis, whereas Treg depletion enhanced late-phase disease.

68 d D2R internalization in SZ leads to blunted late-phase displacement, or a faster return to baseline,

69 acy is the most common cause of attrition in late-phase drug development.

70 l inflammatory mediators, including IL-6, at late phase during the response to lipopolysaccharide cha

71 However, late-phase ear swelling, due to type III hypersensitivit

72 In mouse uteri, early- and late-phase estrogen-regulated gene responses were increa

73 ith right subthalamotomy could not engage in late phase, fast inhibition of the response and showed m

74 an MT ratio of rats injected with PG-PS with late-phase fibrosis was higher than that in rats with ea

75 he MT ratio of rats injected with PG-PS with late-phase fibrosis was higher than that of control anim

76 ations in the Early phase for snakes and the Late phase for monkey faces, but no significant differen

77 ion in which a key step is the activation of late-phase gene expression to produce proteins from whic

78 A subset of late phase genes was expressed in rheumatoid arthritis s

79 Expression of a subset of late phase genes was mediated by autocrine IL-10, which

80 IL-10-STAT3 autocrine loop and expression of late phase genes.

81 otid stenosis in the early (</= 4 weeks) and late phases (>/= 3 months) after TIA or stroke in this p

82 zard ratio [HR]: 1.24; p = 0.04) and reduced late-phase hazard of death (HR: 0.57; p = 0.04) than the

83 s canicula (a representative chondrichthyan) late phase HoxD transcripts are present in cells of the

84 Here we used 'late-phase' imaging after challenge to test the hypothes

85 ge, yet the mechanisms by which the mosquito late-phase immune response limits oocyst survival are le

86 ete-to-oocyst differentiation but mediates a late-phase immune response that decreases oocyst surviva

87 ting hemocytes as critical modulators of the late-phase immune response.

88 1), and (iv) MALDI-TOF MS identification and late phase implementation of TLA (TLA2).

89 g responses and formalin-induced pain in the late phase in mice.

90 scein angiography showed staining during the late phase in the central macula at all follow-up visits

91 The late phase includes responses related to phagocytosis by

92 ge and within an area of hypofluorescence on late-phase indocyanine green angiographic images.

93 y significantly exacerbates the IgE-mediated late phase inflammation in a murine model of passive cut

94 However, the late phase inflammatory pain following complete Freund's

95 The late-phase inhibition of T cell activation is, in part,

96 ated postprandial glucose despite 14% higher late-phase insulin) without change in early-phase insuli

97 ease of luminal Ca(2+) and unevenly inhibits late-phase intracellular Ca(2+) mobilization.

98 Sulindac induced iNOS and Hsp70, late-phase IPC markers in the RPE cells.

99 the repressive effect of IL-1beta during the late phase is mediated through Sp3 recruitment to the pr

100 igen-presenting cell activation, whereas the late phase is related to B-cell activation.

101 During the late phase, LCs and macrophage numbers transiently incre

102 lite cotinine, for > or = 8 h suppressed the late phase (leukotriene/cytokine production) but not deg

103 Using late phase long-term potentiation (L-LTP) in the hippoca

104 negative effects of 6 h of SD on hippocampal late-phase long-term potentiation (L-LTP) and hippocampu

105 ndent BDNF expression impairs BDNF-dependent late-phase long-term potentiation (L-LTP) in CA1, a site

106 Late-phase long-term potentiation (L-LTP), a cellular mo

107 The late-phase long-term potentiation induced in area CA1 us

108 died between December 2008 and May 2009 with late-phase (LP) contrast material-enhanced US by using f

109 f basophils failed to develop early (EPR) or late phase (LPR) nasal responses following allergen sens

110 engineered to bind mutated SRE 6.9 restored late-phase LTD in Arc-/-, SRE 6.9 mutant BAC cells.

111 cells transfected with a wild-type Arc BAC, late-phase LTD was rescued.

112 hods were used to evoke and record early and late phase LTP in the dentate gyrus of anesthetized rats

113 ressed early phase LTP without affecting the late phase LTP of dentate gyrus.

114 CA1 cells; this led to impaired hippocampal late-phase LTP and memory consolidation, with no obvious

115 that MMP-3 inhibition or knock-out impaired late-phase LTP in the CA3-CA1 pathway.

116 a modest decrease in the ability to maintain late-phase LTP induced by three trains of TS.

117 Interestingly, late-phase LTP was also decreased by MMP-9 blockade.

118 -3 and MMP-9 were inhibited, both early- and late-phase LTP was impaired.

119 decaying (early-phase) LTP and nondecaying (late-phase) LTP.

120 d its correlation with early (tryptase)- and late-phase markers (IL-13 levels, eosinophil numbers) of

121 those with chronic/recurring symptoms in the late phase (mean follow-up, 11 years) did have higher ri

122 vioural responses: early-phase analgesia and late-phase mechanical allodynia which requires NMDAR; bo

123 Comparing initial with late phase, median VDP of all subjects decreased from 49

124 process with an increase during middle- and late-phase meiosis.

125 role for dorsal hippocampal dopamine in this late-phase memory consolidation and, unexpectedly, diffe

126 Late-phase microangiography was used to detect trunk lym

127 and larval zebrafish can be quantified using late-phase microangiography.

128 myocardial injection of autologous CSCs in a late phase model of chronic infarction resulted in less

129 ad of the IRAK2-TRAF6 interaction to sustain late-phase mRNA production.

130 complete Freund's adjuvant injection and the late phase neuropathic pain following chronic constricti

131 ng Nox4 demonstrated a substantially reduced late-phase neuropathic pain behavior after peripheral ne

132 jury could upregulate connexin-43 to sustain late-phase neuropathic pain by releasing chemokine from

133 lowing lumbar puncture alleviates early- and late-phase neuropathic pain symptoms, such as allodynia

134 mechanical allodynia, a cardinal feature of late-phase neuropathic pain.

135 release of astrocytic mediators and sustain late-phase neuropathic pain.

136 However, as infection proceeds to the late phase, nucleosomes redistribute extensively to esta

137 of feeding in INT-BDNF(-/-) mice during the late phase of a scheduled meal suggested that increased

138 eading to elevated calcium levels during the late phase of a subsequent excitatory stimulus.

139 and shows elevated calcium levels during the late phase of a subsequent excitatory stimulus.

140 The late phase of adenovirus gene expression is controlled b

141 nt activation of the L4P at the onset of the late phase of adenovirus gene expression.

142 ase of ADO effect only in 12 PVs, during the late phase of ADO effect only in 8 PVs, and during both

143 of both the clinical manifestations and the late phase of allergic conjunctivitis.

144 t checkpoints of the FoxP3 Treg chain in the late phase of alloimmune response and, thus, acts as an

145 hich astrocyte MTSOD1 loss affected only the late phase of ALS disease, we found that astrocyte MTSOD

146 nal-regulating kinase 1 (ASK1) regulates the late phase of APAP-induced JNK activation, but the mitog

147 pathway was required for both the early and late phase of Arc translation during mGluR-LTD, through

148 During the late phase of cardioprotection, antigen immunomodulatory

149 Furthermore, the late phase of cellular inflammation (14-180 days post-in

150 The late phase of cellular inflammation was detected after 1

151 6.9 in the Arc promoter is required for the late phase of cerebellar LTD.

152 luding survival in macrophages or during the late phase of chronic tuberculosis in the murine lungs.

153 and Hsp90beta play an essential role in the late phase of CLC-1 quality control by dynamically coord

154 osA and AfuvelB expression during the mid to late phase of conidiation.

155 Hippocampal dopamine promotes the late phase of consolidation of an aversive step-down avo

156 mplicating cAMP signaling by PDE4B in a very late phase of consolidation.

157 together, these findings describe a distinct late phase of corneal allograft rejection that is likely

158 on null STAT-3 mutant led to the loss of the late phase of cyclin D1 expression.

159 reatment with fingolimod (FTY720) during the late phase of disease revealed that retinal CD8(+) T cel

160 ssion into an early phase of induction and a late phase of down-regulation.

161 dult Ixodes ricinus females during early and late phase of engorgement.

162 Myosin VI knockdown selectively impaired a late phase of exocytosis, consistent with a replenishmen

163 ion without leakage or pooling of dye in the late phase of FA.

164 ith continued life-saving benefit during the late phase of follow-up (5 through 8 years: hazard ratio

165 0-kDa auxiliary protein produced in the very late phase of gene transcription by Autographa californi

166 Finally, a late phase of geochemical modification by saline fluids

167 d kinetics (4-6 hours), establishing a novel late phase of GF signaling that appears to be constituti

168 Late phase of healing occurs a few days postinjury and i

169 impaired both long-term memory (LTM) and the late phase of hippocampal long-term potentiation (L-LTP)

170 During the late phase of HIV-1 infection, Gag polyproteins are tran

171 rability of IN to small molecules during the late phase of HIV-1 replication unveils a pharmacologica

172 ncy is unexpectedly accounted for during the late phase of HIV-1 replication.

173 n coassemble with HIV-1 Gag and modulate the late phase of HIV-1 replication.

174 A late phase of HoxD activation is crucial for the pattern

175 ratio at early and intermediate phases, not late phase of hypoxic-ischemic group.

176 nt for the temporal switch from the early to late phase of infection by regulating both early and lat

177 inant-negative derivative of Nxf1 during the late phase of infection interfered with production of a

178 immune modulation occurs during the early or late phase of infection, assessments of fungal burden an

179 At late phase of infection, enhanced bacterial counts in PF

180 and how it contributes to activation of the late phase of infection, is important to our understandi

181 mmation, coagulation, and homeostasis in the late phase of infection, resulting in a more severe dise

182 ene expression was down-regulated during the late phase of infection, which led to relocation of the

183 per transition of gene expression during the late phase of infection.

184 d after reaching their peak expansion in the late phase of infection.

185 ngs of asthmatics may be responsible for the late phase of inflammatory asthma.

186 II expressed in the motor neuron blocked the late phase of intermediate-term facilitation in sensory-

187 During the late phase of ischemia-reperfusion injury, circulating I

188 In addition, loss of PKR increases the late phase of long-lasting synaptic potentiation (L-LTP)

189 The late phase of long-term potentiation (LTP) at glutamater

190 excitability of neurons and facilitates the late phase of long-term potentiation (LTP) in the Schaff

191 es protein synthesis required to sustain the late phase of long-term potentiation (LTP).

192 ated with the regulation of COX-2 during the late phase of LPS activation in macrophages.

193 n factor SRF or its cofactor MAL blocked the late phase of LTD in mouse cultured cerebellar Purkinje

194 eting TLR4 signaling, was induced during the late phase of lung injury in WT mice, whereas it was inc

195 ost, that are required specifically for this late phase of oskar localization shows that germ plasm a

196 ion of analgesia was markedly shorter in the late phase of oxaliplatin neuropathy and in alcoholic ne

197 n, PACAP stimulated Akt phosphorylation in a late phase of PAC(1)HOP1 receptor signaling.

198 f IR and subsequently replenished during the late phase of post-IR genome reassembly.

199 virus, UL103 appears to function during the late phase of replication, playing a critical role in eg

200 lted in the inhibition of both the early and late phase of ROS generation, without affecting the earl

201 onstrate that Cdc7 regulates the initial and late phase of SM differentiation through distinct mechan

202 g the nascent Tfh cell-like phenotype in the late phase of Th1 cell specification.

203 associated with a high mortality during the late phase of the acute hospital stay.

204 anti-CD28 stimulation/allostimulation in the late phase of the alloimmune response.

205 o tachy-arrhythmias due to the fact that the late phase of the cardiac action potential is highly sus

206 The late phase of the human papillomavirus (HPV) life cycle

207 l for sustained T cell activation during the late phase of the immune response.

208 e other, phage DNA movement slows during the late phase of the lytic cycle, whereas it remains the sa

209 ut the train of 10 stimuli and dominated the late phase of the train EPSC.

210 protein (MAVS) signaling is crucial for the late phase of the type I IFN response to LCMV.

211 However, knockdown of Src abolished the late phase of TLR3 Tyr-759 phosphorylation and decreased

212 is during the early phase but not during the late phase of tumor growth.

213 lls have difficulty distinguishing early and late phases of a transcriptional cascade or identifying

214 While it is clear that the late phases of adipocyte maturation are governed by the

215 ect only in 8 PVs, and during both early and late phases of ADO effect in 8 PVs.

216 lays critical but diverse roles in early and late phases of antibody responses and plasma cell differ

217 lly preceded dynamin2 recruitment during the late phases of CME, and promoted dynamin recruitment.

218 elopment comprises the coupling of early and late phases of conserved gene expression.

219 t not ROCK, markedly reduced the initial and late phases of contraction in a non-additive manner and

220 ific antagonist reduced both the initial and late phases of contraction with a significant decrease i

221 dherin-6B (Cad6B) are expressed in early and late phases of cranial motoneuron development, respectiv

222 We hypothesized that cells in late phases of differentiation would be selectively less

223 demonstrate a dissociation between early and late phases of encoding processes.

224 strated the role of EhRab35 in the early and late phases of erythrophagocytosis by the amoeba.

225 w-titer anti-WNV antibodies during early and late phases of infection.

226 han an Opa-deficient mutant in the early and late phases of infection.

227 ne expression shows that there are early and late phases of infection.

228 d with biological processes in the early and late phases of ischemia-reperfusion injury.

229 for both long-term memory consolidation and late phases of long-term potentiation and long-term depr

230 with the retromer complex at both early and late phases of macropinosome maturation, but mediates re

231 phase, whereas CXCL8 plays a key role in the late phases of recruitment, but the crosstalks between t

232 sequent trafficking steps, such as early and late phases of recycling of AT1-R in human embryonic kid

233 s that display defects during both early and late phases of retinal neurogenesis.

234 target for the management of both early and late phases of severe SAg-mediated illnesses.

235 P3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respective

236 the role of mast cells in both the early and late phases of the inflammatory response in experimental

237 on of formalin-induced behavior in early and late phases of the mouse intradermal formalin test of pa

238 istinct levels that operate in the early and late phases of the response.

239 amily of proteins and affects both early and late phases of the retroviral life cycle.

240 nown functions of UPF3B during the early and late phases of translation termination suggest that UPF3

241 ndicating progression into the late and very late phases of viral infection.

242 In mouse limbs the autopod is built by a "late" phase of Hoxd and Hoxa gene expression, orchestrat

243 The persistent or "late" phase of long-term potentiation (L-LTP), which req

244 The late-phase of long-term potentiation (L-LTP), the cellul

245 of a wide range of durations; by minimizing late phase oscillations response durations may be fine-t

246 pain-induced analgesia in groups with either late-phase oxaliplatin neuropathy, alcoholic neuropathy,

247 animals that did not develop fibrosis in the late phase (P = .0001).

248 t do not correlate with other immediate- and late-phase parameters.

249 the formation of new stable synapses during late-phase plasticity.

250 te phase, and extensive neuronal loss in the late phase postreoxygenation.

251 UMO-2 from Mre11 and Nbs1, indicating that a late-phase process is involved in Mre11 and Nbs1 desumoy

252 ligase-inactive TRAF6[L74H] mutant, but the late-phase production of IL-6, IL-12, and TNFalpha (cont

253 rse outcome, patients with AHF have a better late phase prognosis compared with patients with Cr-HF (

254 ned PKA activation and greater inhibition of late-phase promitogenic p42/p44 and PI3K activities.

255 ase (r = 0.363, P = 0.03 one-tailed) and the late phase (r = 0.538, P = 0.004).

256 at the level of the conjunctiva reflects the late-phase reaction.

257 asma NPY and increase in platelet NPY during late-phase recovery.

258 results suggest a considerable deficiency in late-phase replication and viral assembly during VZV inf

259 phosphorylated in a biphasic manner, and the late phase requires NFATc1-mediated p300-dependent acety

260 ncreases memory when applied at the early or late phases, respectively.

261 ts reveal an mTORC1-dependent IL-10-mediated late phase response to TNF by primary human macrophages,

262 erapy (SCIT) using the allergen-induced skin late-phase response (LPR) and exploratory immune monitor

263 AQX-1125 significantly attenuated the late-phase response compared with placebo (FEV1 4-10 h:

264 ild-to-moderate asthmatics with a documented late-phase response to inhaled allergen (LAR).

265 unctivitis was evaluated clinically, and the late-phase response was assessed by histopathology.

266 The suppressive effect of nicotine on the late-phase response was blocked by the alpha7/alpha9-nAC

267 onse, EPR) and 24 h after the 6th challenge (late-phase response, LPR).

268 exerts negative regulation over IgE-induced late phase responses and cytokine production in mast cel

269 om older donors have diminished induction of late-phase responses (eg, STAT1, IRF7, and IRF1), sugges

270 ermal allergen immunotherapy suppressed skin late-phase responses but was not clinically effective an

271 ection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcut

272 essed by bronchoalveolar lavage (BAL) during late-phase responses following allergen challenge of all

273 Late-phase responses remained inhibited 7 months after t

274 ly, fingolimod attenuates both immediate and late-phase responses to histamine with reduced extravasa

275 e that basophil activation during early- and late-phase responses to inhaled allergen might be driven

276 es predominated early on in response to LCS, late-phase responses were characterized by up- and downr

277 d after intradermal allergen challenges, and late-phase responses were measured 4 and 7, 10, or 13 mo

278 Furthermore, early and late phases resulting from allergen exposure were shown

279 immune system surveillance, whereas, in the late phases, shigellae harboring immunopotent LPS are fu

280 Only the late phase showed significant correlations with perceptu

281 e allergen-specific T cells, they may reduce late-phase side-effects during SIT.

282 rvation spine density decreases and during a late phase spine density recovers again.

283 DNF synthesis is required for spine pruning, late-phase spine maturation, and recovery of cortical re

284 efficiency, and thus more applicability for late-phase studies, or greater statistical efficiency bu

285 ver, unlike with PCA responses, there was no late-phase swelling.

286 emonstrated that their absence resulted in a late phase that is associated with enhanced neutrophil i

287 s spread over most of the imaged area, and a late phase that was spatially confined.

288 ing stathmin-tubulin binding, whereas in the late phase these processes are reversed leading to an in

289 al roles in moving the infection on into the late phase; these two proteins are produced by the actio

290 ilitate the transition of these therapies to late phase trials and to evaluate closely histocompatibi

291 e, a (99m)Tc-labeled folate conjugate, is in late-phase trials in Europe and the United States.

292 cose-avid lymphomas in clinical practice and late-phase trials.

293 mission and maintain neuropathic pain in the late-phase via releasing chemokines.

294 ibutes to an efficient switch from early- to late-phase virus gene expression.

295 seconds (P = .002) and significantly reduced late-phase washout slope (P = .002) when compared with h

296 slope of the first-pass peak (P = .011), and late-phase washout slope (P = .032), estimated by using

297 (HR, 4.38 [95% CI, 1.39-13.81]), and in the late phase were nonmyeloablative conditioning regimen (H

298 ional brain activations during the early and late phases were compared with a longitudinal measure of

299 th PG-PS developed increased fibrosis in the late phase, whereas control rats did not.

300 Finally, downstream factors derived from the late phase, which do not include Oct4, Sox2, Klf4, c-Myc