ライフサイエンスコーパス: late-stage

1 cological cancers, with diagnosis often at a late stage.

2 tly from 6% at the early stage to 11% at the late stage.

3 erous ovarian cancer, typically diagnosed at late stage.

4 atic cancer evolves slowly and presents at a late stage.

5 n polysulfide to magnesium sulfide occurs at late stage.

6 on visual inspection by non-specialists at a late-stage.

7 jority of cases oral SCC is diagnosed in its late stages.

8 s into a clear pro-inflammatory phenotype at late stages.

9 of tumor growth and metastasis from early to late stages.

10 nding site on native tau aggregates in human late-stage AD brain tissue.

11 eta was elevated in patients with early- and late-stage AD dementia, but not in high pathology nondem

12 subsequent alpha-ketol rearrangement, and a late stage aldol reaction to furnish the complex cage-li

13 and hapalindole alkaloids with chlorine via late-stage aliphatic C-H group functionalization.

14 The successful strategy relied on late-stage allylic oxidations at two separate positions

15 tentially superior symptomatic treatments in late-stage Alzheimer's disease.

16 were 59.5 (95% CI, 50.8-68.1) for those with late-stage AMD and 79.4 (95% CI, 72.5-86.1) for those wi

17 ticides were associated with both early- and late-stage AMD, but others were associated with only one

18 hesis of narciclasine is accomplished by the late-stage, amide-directed C-H hydroxylation of a lycori

19 -)-nicotine and antidepressant sertraline by late-stage amination and azidation reactions.

20 a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involvin

21 ressive cancers are typically diagnosed at a late stage and are characterized by TP53 mutations and p

22 aceutical industry to reduce drug failure at late stage and thus reduce the cost of developing a new

23 MGs) were identified in the intermediate and late stages and during the transition from intermediate

24 nd C2/V3 regions of the HIV-1 env gene in 30 late-stage and 6 early-stage subjects.

25 hese alkaloids required the development of a late-stage and highly selective C-H oxidation of complex

26 se of complex I deficiency associated with a late stage assembly defect and emphasize the role of int

27 Colliding stellar winds from late-stage, asymptotic-giant-branch stars are often sugg

28 mortality compared with thinner lesions, and late stage at diagnosis was associated with increased al

29 ditions displayed the typical signature of a late stage biofilm, suggesting that biofilm formation is

30 s due to failure to transcriptionally induce late stage biotin biosynthetic genes in low biotin condi

31 between-study heterogeneity in percentage of late-stage breast cancer (stage III/IV), and meta-regres

32 Percentages of women with late-stage breast cancer at diagnosis in sub-Saharan Afr

33 TGF-beta is pro-metastatic for the late-stage breast cancer cells.

34 ffective antitumor agent in the treatment of late-stage breast cancer.

35 Cs by inducing their proliferation and, at a late stage, by modulating OPC maturation.

36 use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natural produ

37 idant, making the procedure suitable for the late-stage C-H alkylation of complex molecules.

38 One such operation is a tailored late-stage C-H functionalization converting a carboxylic

39 Visible-light photocatalyzed (VLPC) late-stage C-H functionalization is a powerful addition

40 This late-stage C-H oxidation chemistry is strategically crit

41 Strategically, the synthesis relies on a late-stage C-H oxidation of an advanced intermediate.

42 ng a proline turn element is transformed via late-stage C-H oxidation to one containing a linear unna

43 Oridamycin B was accessed through a late-stage, C-H oxidation that converted the C16 methyl

44 ) have been achieved by the development of a late-stage C3-C8' Friedel-Crafts union of polycyclic dik

45 orted in the last decade in the treatment of late-stage cancer with targeted and immune-based therapi

46 This has important implications for late-stage candidate selection and assessing how they ca

47 arkers did not distinguish between early and late-stage cases but were associated with neuroinflammat

48 C effector p21-activated kinase (PAK) are in late-stage clinical development and might impede oncogen

49 challenges, there are vaccine candidates in late-stage clinical development for C. difficile, S. aur

50 -kinase-delta (PI3K-delta) and PI3K-gamma in late-stage clinical development for hematologic malignan

51 seases have been recently approved or are in late-stage clinical development, and new delivery modali

52 PI3Kalpha inhibitors, now in late-stage clinical development, elicit a robust compens

53 e prodrug Mipsagargin, which is currently in late-stage clinical trials for the treatment of cancer,

54 h to target the globo-series glycans and the late-stage clinical trials of a breast cancer vaccine.

55 odes of action, are being evaluated in large late-stage clinical trials, and many more are in early c

56 The route features late-stage conformation-controlled highly regioselective

57 tones at room temperature and is amenable to late-stage coupling of complex and biologically relevant

58 ted with poorer CRC prognosis, especially in late stage CRC.

59 ia a seemingly attractive strategy involving late-stage creation of the central seven-membered ring.

60 ivinyl carbinol derivative and high-yielding late-stage cross-metathesis and Yamaguchi macrolactoniza

61 Late-stage diagnosis of lung cancer occurs 95% of the t

62 oor skin cancer outcomes, in part because of late-stage diagnosis.

63 , or II), and 48 (51.6%) were diagnosed with late-stage disease (AJCC stage III or IV).

64 II; HR, 1.61; 95% CI, 1.26 to 2.04), but not late-stage disease (stages III and IV; HR, 1.05; 95% CI,

65 een-study heterogeneity in the percentage of late-stage disease at diagnosis (median 74.7%, range 30.

66 The percentage of patients with late-stage disease at diagnosis in black Africans decrea

67 Left untreated, syphilis can progress to late-stage disease in about 15% of persons who are infec

68 apse-associated p-tau did not increase until late-stage disease in human and transgenic rat cortex, a

69 eld of biomedical sciences from treatment of late-stage disease symptoms to early detection and preve

70 s with AL amyloid is essential given that in late-stage disease with extensive amyloid load, our data

71 gnosis continues to be made in patients with late-stage disease, suggesting that more needs to be don

72 inhibition of tumor progression in early and late-stage disease.

73 in-43 (Cx43), a protein previously linked to late-stage disease.

74 rucially (iii) facile access to basidalin by late-stage dithiane removal.

75 atalyst and establishes a novel platform for late-stage diversification of a range of complex natural

76 methodology was successfully applied to the late-stage diversification of natural products and a mar

77 samicin classes of macrolide antibiotics via late-stage diversification.

78 on the periphery of the heteroaryl ring for late-stage diversification.

79 e of gamma-aminobutyric acid (GABA), various late-stage diversifications, and by mimicking enzymatic

80 selective borylative enyne cyclization and a late-stage double allylic C-H oxidation as well as adapt

81 eet microscopy (RLSM) to image highly opaque late-stage Drosophila embryos.

82 oarenes (55 examples), including examples of late-stage drug derivatization.

83 d by prion protein overexpression, occurs at late stages during 263K prion disease and that this dysf

84 low in the early stage which reversed in the late stage, e.g. HES1/NR3C1 binding to CLDN1 promoter de

85 d also works well for staining embryos, even late-stage embryos with cuticles, allowing characterizat

86 hat breathing normobaric 11% O2 in mice with late-stage encephalopathy reverses their established neu

87 en suggested that confidence may depend on a late-stage estimation dissociable from perceptual proces

88 The appearance of late-stage fluorination reactions catalyzed by transitio

89 Ceiling effects may occur at late stages, for both scales.

90 n the assumption that the behaviour of these late-stage freshwater glass eels, and their responses to

91 l chemists to consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C

92 The procedure is ideal for late stage functionalization in parallel medicinal chemi

93 ion for 'The medicinal chemist's toolbox for late stage functionalization of drug-like molecules' by

94 ze these substituted molecules, and enabling late stage functionalization of spiroligomer termini.

95 thetic applications in de novo synthesis and late-stage functionalization chemistry.

96 d), and has been successfully applied to the late-stage functionalization of amide- and lactam-contai

97 precise GNR heterojunctions prepared through late-stage functionalization of chevron GNRs obtained fr

98 0 examples) at low Pd loading, including the late-stage functionalization of commercial drugs.

99 icability of this method of synthesis to the late-stage functionalization of complex molecules.

100 ness of this protocol is demonstrated on the late-stage functionalization of complex nitrogen-contain

101 oad functional group tolerance, enabling the late-stage functionalization of drug-like molecules.

102 ation to pharmaceuticals, agrochemicals, and late-stage functionalization reactions on complex molecu

103 nge of secondary amines and can be used as a late-stage functionalization tactic to deliver advanced,

104 f our synthetic efforts include an efficient late-stage functionalization that allows for the prepara

105 hylthiolation, which has high potential as a late-stage functionalization tool.

106 roach is then described as a quintessential "late-stage functionalization" exercise wherein natural p

107 onstrated in drug intermediate synthesis and late-stage functionalization.

108 Further, late-stage functionalizations of the vinyl ether moiety

109 t classical acylations and can be applied to late-stage functionalizations.

110 n clots by the extrinsic pathway followed by late-stage FXIa contributions, with fibrin localizing th

111 e chemotypes described for the first time as late-stage gametocyte-targeting molecules.

112 lly adapted to freshwater; that is, they are late-stage glass eels ( approximately 2 years old), not

113 ural products, drug candidates, allowing for late-stage glycodiversification studies with small molec

114 ccharide thioglycoside donors, followed by a late-stage glycosylation of heptagalactan backbone accep

115 ells of developing post-MET colonies until a late stage (>200 cells), demonstrating that OCT4-activat

116 d that the Early Stage (20-50 years) and the Late Stage (>80 years) fungal communities were nested wi

117 flavin-dependent halogenases involved in the late-stage halogenation of malbrancheamide in two differ

118 abolites in the inflammatory pathogenesis of late-stage HAT.

119 ement, 5-year survival rate in patients with late-stage head and neck squamous cell carcinoma (HNSCC)

120 id substrate metabolism is characteristic of late-stage heart failure and has limited treatment optio

121 In the late stage, HeLa cells change from proliferating to migr

122 the application of C-H functionalization in late-stage heterocycle drug discovery.

123 tal synthesis of (-)-communesin F based on a late-stage heterodimerization and aminal exchange is des

124 Similar effects were noted for late-stage HIV disease progression on information proces

125 Despite commonly presenting at late stage, HPV-driven OPSCCs are associated with improv

126 5/5 cures in murine models of both early and late stage human African trypanosomiasis, representing a

127 , metabolism and excretion (ADME) studies to late-stage human clinical trials--to elucidate a drug mo

128 otypic and molecular features of aggressive, late-stage human disease.

129 al antigen (CrAg) screening in patients with late-stage human immunodeficiency virus (HIV) initiating

130 milar to dysfunctional T cells isolated from late-stage human tumors.

131 under mildly basic conditions and enable the late-stage hydroxylation of several functionally-dense d

132 To illustrate the synthetic value at a late stage in a complex molecule synthesis, ketone 4sc,

133 ple the two halves of the final product at a late stage in the synthesis.

134 studies indicated that sorafenib targeted a late stage in virus infection and caused a buildup of vi

135 oughout the primate visual system, including late stages in the ventral visual hierarchy, and support

136 y during avibirnavirus infection, especially late stage infection, remains unclear.

137 ved in only half of infected macaques during late-stage infection (LSI).

138 During late-stage infection, both mice depleted of GPVI and GPV

139 s prior to the current diagnostic cutoff for late-stage infection, providing evidence for early CNS i

140 two closely related approaches involving the late-stage installation of the isomerization-prone (2Z,4

141 We identified a late-stage intermediate in which LptD is folded around L

142 Resolution of a late-stage intermediate via chiral HPLC allowed for the

143 ort a highly stereocontrolled synthesis of a late-stage intermediate, the "Corey dione", from which D

144 antiopure (S)-econazole and (R)-mirabegron a late-stage intermediate.

145 nctionalization of small building blocks and late-stage intermediates, the methodology has been appli

146 organs in the brain or leaky vasculature of late-stage intracranial tumors.

147 The synthesis of (-)-1 was completed by a late-stage intramolecular Diels-Alder furan (IMDAF) cycl

148 assembly at an early step distinct from the late stage involving PTAP binding disruption.

149 lide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds s

150 to their biconcave shape, whereas schizonts (late-stage iRBCs) tend to roll due to their almost spher

151 ensional culture obtained from patients with late-stage knee OA and nidogen-2 knockout mice.

152 to generate the cis-decalin skeleton, and a late-stage large fragment union exploiting a Micalizio a

153 noglobulin G Western blots, performs well in late-stage LD but is insensitive in patients with erythe

154 The synthesis also features a late-stage lithiation-borylation reaction with a tertiar

155 Here we argue that this late-stage low-delta(18)O component is derived from hydr

156 een interpreted as evidence of water-limited late-stage Martian melts.

157 IL15 greatly enhances CD57 upregulation and late-stage maturation.

158 ostication of OS and hematologic toxicity in late-stage mCRPC patients receiving (223)RaCl2 Further p

159 um iodide/Hoechst staining assay assess only late stage membrane permeability.

160 pression in the tumor-reactive stroma during late-stage metastasis in the lung.

161 ary vs metastatic tumor setting, or early vs late stage metastatic disease, when undergoing vector de

162 original tumor phenotype in vivo and mirror late stage metastatic disease.

163 er1-dependent generation of mature miRNAs in late-stage MKs and platelets modulates the expression of

164 endent Lewis acidic boranes were prepared by late-stage modification of an active hydrogen-transfer c

165 We successfully applied this method to the late-stage modification of chiral catalyst templates, th

166 t functionalities, and have been used in the late-stage modification of complex and high-value N-cont

167 locks and will facilitate the preparation or late-stage modification of complex oligosaccharides for

168 process can be used for the construction and late-stage modification of important molecular scaffolds

169 t of designer biocatalysis for the selective late-stage modification of unactivated aliphatic carbon

170 g protocol was applied in drug synthesis and late-stage modifications of active pharmaceutical ingred

171 The reaction was utilized for the late-stage mono- and dichlorination of a range of target

172 ance of satellite cells, but its function in late-stage myogenesis, i.e. post-differentiation myocyte

173 everal transcription factors associated with late-stage NK-cell maturation including T-BET, ZEB2, and

174 s used to detect and quantify atrophy due to late-stage non-neovascular and neovascular age-related m

175 n accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stag

176 ture of azaspiracid-3 has been achieved by a late-stage Nozaki-Hiyama-Kishi coupling to form the C21-

177 ulator in cardiomyocyte proliferation at the late stage of cardiac differentiation from human ESCs.

178 , suggesting that DC-STAMP is engaged in the late stage of cell fusion.

179 s it could represent a therapeutic target in late stage of CKD.

180 nsport in the nanoscale viral channel at the late stage of DNA packaging could be a consequence of Br

181 At the late stage of DNA packaging, the negatively charged geno

182 ting GP10 may not be a static channel at the late stage of DNA packaging.

183 or the other occurring only at a relatively late stage of folding.

184 ned at a slightly activated level during the late stage of fracture healing to ensure better bone fra

185 t different levels or deleted in mice at the late stage of fracture healing, and the effects on heali

186 cteroid development was blocked, either at a late stage of infection thread progression or during bac

187 autophagy enhances viral replication at the late stage of infection, and the autophagy pathway facil

188 ristics typical of autophagosomes during the late stage of infection.

189 nfected Ccr5(-/-) mice was documented at the late stage of infection.

190 ster in a Y-tube olfactometer bioassay, at a late stage of infection.

191 We also discovered that during the late stage of lytic replication, KSHV selectively degrad

192 caffolding the axon/myelin-unit, evidently a late stage of myelin maturation.

193 d during the transition from intermediate to late stage of OA in the subchondral bone.

194 words can be activated automatically in the late stage of recognition, even when semantic processing

195 ; (2) flagellum-based motility in the mid to late stage of recovery; and (3) recovery phase-specific

196 ec4) leads to kinetic transport defects at a late stage of the pathway, with secretory vesicles accum

197 hamnose into a 6-deoxy-L-talose residue at a late stage of the synthetic sequence.

198 hosphorylated subsequently to facilitate the late stage of viral DNA synthesis and to stabilize NCs c

199 Here we quantified these contributions at a late stage of visual processing [frontal eye field (FEF)

200 desirable bioisosteres at both the early and late stages of a synthesis.

201 oproteins E1 and E2 are generated during the late stages of acute infection, yet their contribution t

202 ipogenic capability of ASCs at early but not late stages of adipogenesis, which can be reversed by an

203 RS-CoV exhibit pathology consistent with the late stages of ARDS, which is reminiscent of the disease

204 at bacterial YjeQ (RsgA) participates in the late stages of assembly of the 30S subunit and aids the

205 In this study we evaluated the late stages of B-cell differentiation in a heterogeneous

206 dicator species for early, intermediate, and late stages of biofilm formation.

207 ducible factor 1-alpha (HIF1A) inhibition in late stages of bleomycin-induced injury attenuates pulmo

208 pies are more effective in early stages than late stages of chronic liver diseases, so enabling early

209 n the United States and Europe and agents in late stages of clinical development.

210 ous membrane removal predominates during the late stages of cytokinesis, mediated by both dynamin and

211 ha-farnesene, was detected at the middle and late stages of development, suggesting a development-spe

212 to the accumulation of Met in their seeds at late stages of development.

213 t the cell cycle as regulated by EKLF during late stages of differentiation is inherently critical fo

214 ence microscopy to survey early, middle, and late stages of differentiation of null mutants from the

215 nedistat) or siRNA against nedd8 in early or late stages of differentiation on C2C12 myoblasts, and p

216 t bacterial copper-binding protein, at three late stages of disease in a WD rat model.

217 fects on AD-related pathologies at early and late stages of disease progression, unifying previous wo

218 central foveal structure is maintained until late stages of disease, which may contribute to preserva

219 n in CSF was increased in both the early and late stages of disease, with a progressive increase in t

220 diating the transition between the early and late stages of drought, we used Bayesian network modelin

221 g is involved in diencephalic development at late stages of embryonic development, but its roles and

222 d common modifications between the early and late stages of HCC development likely involved in the st

223 er, selective effects of UBE3A disruption at late stages of in vitro development suggest that changes

224 spersed and/or prevented from forming during late stages of infection despite continued activation of

225 es and perforin expression at both early and late stages of infection in vivo and repressed the trans

226 though the function of MT alterations during late stages of infection requires further study, ORF52 s

227 hanges in the cytoskeleton at both early and late stages of infection.

228 emale reproductive tissues, during early and late stages of infection.

229 ve site residues, which was installed in the late stages of laboratory evolution, apparently enhances

230 ponents involved in disruption of SGs during late stages of MRV infection remain to be elucidated.

231 vation changes associated with the early and late stages of naive cell formation.

232 d2 as a fine-tuner of gene expression during late stages of pancreatic endocrine cell development.

233 We demonstrate that early and late stages of prion infection are differentially sensit

234 The induction of necroptosis also requires late stages of reovirus infection.

235 ng intercellular connectivity alterations at late stages of the disease.

236 low efficacy of antiplague therapies during late stages of the infection.

237 in litter quality played a major role in the late stages of the process.

238 ntial Rab GTPases that control the early and late stages of the yeast secretory pathway, respectively

239 arphis negatively regulates transcription at late stages of TLR-induced proinflammatory gene expressi

240 the transition from 12S and 13S to 9S RNA at late stages of virus replication.

241 lastosis and early actinic keratosis to the 'late' stages of epidermal carcinogenesis; late actinic k

242 However, activation at a late-stage of CKD abrogated both renal dysfunction and f

243 Receiving a solid organ transplant owing to late-stage organ failure, followed by long-term immunosu

244 te receptors appear only or predominantly in late-stage organoids.

245 lycopeptide was successfully accomplished by late stage oxidation using (2,2,6,6-tetramethyl-piperidi

246 ng through a Friedel-Crafts triflation and a late-stage oxidation of a furan ring.

247 uran motif while a first approach based on a late-stage oxidation was unsuccessful.

248 This novel imidate strategy facilitates late-stage oxidations in a broader scope of medicinally

249 -mix-beta dihydroxylation step followed by a late-stage palladium-catalyzed decarboxylation-allylatio

250 EVs, distinguishing patients with early- and late-stage pancreatic cancer from healthy donors and pat

251 on (STN DBS) is increasingly used in mid- to late-stage Parkinson's disease (PD) but with an incomple

252 Chemotherapy remains the major treatment for late-stage patients.

253 , we show the feasibility of compound I as a late-stage preclinical candidate by establishing synergi

254 Amenable to late-stage preparation of analogues, a flexible and conv

255 d can serve as a powerful synthetic tool for late-stage preparation of complex OCF2H-containing organ

256 erentiating amacrine and ganglion cells, and late-stage progenitors or maturing Muller glia.

257 While these have allowed accurate late-stage prognosis, early diagnosis is still a major c

258 remains predictive even after adjustment for late-stage prognostic markers.

259 ent stratification and targeted therapies in late stage prostate cancer.

260 tor auris longus muscle from male and female late-stage R6/2 mice and age-matched wild-type controls.

261 Coupled with a late-stage radical cyclization to construct the [3.2.2]-

262 ese PET tracers can be synthesised either by late-stage radiofluorination, introducing fluorine-18 in

263 criptional responses participating mostly in late-stage recovery rather than in generating an immedia

264 ses, venetoclax treatment was commenced in 2 late-stage refractory T-PLL patients resulting in clinic

265 ive regulation of extracellular proteases in late stage regeneration.

266 FGF signaling has emerged as a significant "late-stage" regulator of myelin thickness in the CNS, in

267 In conclusion, late-stage renal tubular HIF-2alpha activation has prote

268 rom asymmetric to symmetric cell division in late stage reprogramming.

269 Furthermore, most cancers are diagnosed at a late stage, resulting in a lower cancer survival rate th

270 th Notch signaling and MG differentiation in late-stage retinal progenitor cells (RPCs).

271 ituents on the lactam/sultam ring and allows late stage sequential functionalization of the amine and

272 eduction in angiogenic switching, whereas at late stages, several tumorigenic phenotypes are unexpect

273 of the transformation is demonstrated in the late-stage site-selective functionalization of natural p

274 ility of our approach is demonstrated by the late-stage site-selective functionalizations of complex

275 e into a transcriptionally inactive state in late-stage spermatids.

276 iated mutation FUS R521G, but contrasts with late-stage sporadic ALS patients.

277 This late-stage strategy provides an attractive route to (18)

278 f azole hemiaminals has been developed using late-stage structural modifications of the tert-leucinol

279 anipulation of the C(11) position, employing late-stage synthetic intermediates from our irciniastati

280 system is an attractive alternative to treat late-stage T2DM conditions that require repeated insulin

281 A late-stage TEMPO-mediated regioselective oxidation has b

282 a case study to show that quartz can resolve late-stage temporal changes in magmatic delta(18)O value

283 se results reveal important roles of H2AX in late-stage terminal erythropoiesis and hematopoietic ste

284 Therefore, in addition to late-stage terrestrial accretion of halogens and mantle

285 consistent with volatile-rich or water-rich late-stage terrestrial accretion.

286 In the late stages, the patterns tend toward statistically isot

287 h most lung cancers are still diagnosed at a late stage, there have been significant advances in scre

288 blished thyroiditis cases; Group 4: advanced-late stage thyroiditis cases.

289 pendent RNA polymerase and intermediate- and late-stage transcription initiation and elongation facto

290 The growth of late-stage tumor cells can be targeted by Runx2 knockdow

291 ost-chemotherapy increased the proportion of late-stage tumors.

292 d accelerated progression of both early- and late-stage tumors.

293 01), macro vascular invasion (P < 0.001) and late stage tumours (P < 0.001) had AFP over 400 ng/ml.

294 The synthesis proceeds by late-stage union of two complex precursors (e.g., 28 + 1

295 rhesus macaque model, which is critical for late-stage vaccine testing, we demonstrate that monocyti

296 te-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94;

297 at mediates nuclear export of intron-bearing late-stage viral mRNAs.

298 Most patients are diagnosed in late stages when liver decompensation or liver cancer de

299 patic background might favor (18)F-DCFPyL in late stages, when rare cases of liver metastases can occ

300 ch for terminal allyl amide synthesis, and a late-stage Z,Z-selective Suzuki coupling.