ライフサイエンスコーパス: latency

1 cooperate with neuronal factors to maintain latency.

2 equired to maintain the viral episome during latency.

3 y in vivo, as well as adjustable channel off latency.

4 t are expressed in type III (but not type I) latency.

5 me to facilitate parasite transition towards latency.

6 exocytosis with high probability and minimal latency.

7 at they use distinct mechanisms to establish latency.

8 ither external exposure or reactivation from latency.

9 ifests as a progressive increase in response latency.

10 erstanding of the processes regulating HIV-1 latency.

11 ecision between active replication and viral latency.

12 hat regulate viral gene transcription during latency.

13 and replication, precluding establishment of latency.

14 of VOR for effective serial reversal of HIV latency.

15 increase in the stimulus-selective response latency.

16 that miR-H2 might target other genes during latency.

17 defence mechanisms during reactivation from latency.

18 ole, DHA significantly prolonged the seizure latency.

19 of K-Rta and is responsible for maintaining latency.

20 es) become pathogenic when reactivating from latency.

21 especially their potential to reactivate HIV latency.

22 activation during the establishment of viral latency.

23 d host immune mechanisms that maintain viral latency.

24 tivity contribute to the modulation of HIV-1 latency.

25 e repression of lytic gene expression during latency.

26 for force-dependent release of TGF-beta from latency.

27 cription, thus allowing the establishment of latency.

28 cted cells following reactivation from HIV-1 latency.

29 of functions to establish and maintain KSHV latency.

30 ffects of both nicotine and GTS-21 on attack latency.

31 and contributed to the maintenance of HIV-1 latency.

32 atus of chromatin largely contributes to HIV latency.

33 high-frequency band predicted picture-naming latencies.

34 own intrinsic auditory and visual processing latencies.

35 ur in the same learning episode at different latencies.

36 eloid, T- and B-cell malignancies after long latencies.

37 in timing and precision of startle response latencies.

38 speed were highly correlated with faster VEP latencies.

39 estigate their impact on full-blown PML-IRIS latency; (2) an analysis of variance ANOVA to investigat

40 howed significantly (P < 0.001) longer tumor latency (262 vs. 293 vs. 225 days), fewer pulmonary meta

41 EPSPs were greatly attenuated after a short latency (50 ms) following burst-like PFC electrical stim

42 Short-latency (80-140 ms) striatal responses to a first target

43 tly increase survival; however, after a long latency, all tumors subsequently became resistant.

44 rom Muc4(ko)/NDL female mice exhibit similar latencies and growth rates as Muc4(wt)/NDL animals.

45 d potentials were linearly correlated to the latencies and precision of the first evoked action poten

46 MGBv neurons were identified by their short latencies and sharp tuning curves.

47 ent with the distribution of cortical neuron latencies and that temporal motion integration for pursu

48 intensity-dependent decrease in first spike latencies and their jitter, which could account for the

49 h and tested the hypothesis that first spike latencies and their precision (jitter) determine the ons

50 ith corresponding changes in field potential latencies and their precision.

51 Single-flash cone b-wave latency and 30-Hz flicker latency responses were signifi

52 ice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss of Ptpr

53 mmon type (pVEP) and useful parameters (P100 latency and amplitude) of EPS, and supports further rese

54 2-H4K20me1-L3MBTL1 axis contributes to HIV-1 latency and can be targeted with small-molecule SMYD2 in

55 on state.IMPORTANCE Epstein-Barr virus (EBV) latency and carcinogenesis involve the selective epigene

56 an experimental hematopoietic cell model of latency and cells from naturally infected, healthy human

57 rmore, in deprived animals, both first-spike latency and first-spike latency jitter increased, while

58 Given the long latency and incomplete penetrance of AD dementia with re

59 drenal precursor cells, leading to a reduced latency and increased penetrance of neuroblastomagenesis

60 Addition of wild-type PDGFRA decreases latency and increases tumor invasion, while ATRX knockdo

61 upted by methamphetamine by decreasing sleep latency and increasing sleep efficiency compared with ve

62 Epstein-Barr virus (EBV) latency and its associated carcinogenesis are regulated

63 play an important role in EBV infection and latency and its related cancers.IMPORTANCE The tumor sup

64 t re-identification schemes suffer from high latency and limited access.

65 ses allowed for discrimination between short-latency and long-latency C-starts (SLCs vs. LLCs) in lar

66 mitochondrial haplotypes alter primary tumor latency and metastatic efficiency.

67 derstanding of the molecular basis for viral latency and persistence is paramount to controlling or e

68 stablishment of human cytomegalovirus (HCMV) latency and persistence relies on the successful infecti

69 l can be used to study mechanisms regulating latency and potential therapeutic approaches to reactiva

70 horylation contributes to the maintenance of latency and provides a crucial role in the timing of rea

71 gh the ability of gammaHV to reactivate from latency and re-enter the lytic phase is challenging to i

72 in vivo; in neurons, the virus can establish latency and reactivate to produce infectious virus.

73 l may provide a valuable tool to study viral latency and reactivation as well as evaluate HCMV vaccin

74 ind several sites in the HSV-1 genome during latency and reactivation, but its function has not been

75 ofluidic-based human neuronal model of viral latency and reactivation, we found that inhibition of th

76 the Hic-5(-/-);PyMT mice exhibited increased latency and reduced growth, with fewer lung metastases,

77 mpact on regulating the switch between viral latency and replication.

78 ith changes in E12; however, the presence of latency and split potentials were associated with higher

79 ngeable for establishment and maintenance of latency and suggest that repression of lytic replication

80 translational control underlies ART-induced latency and that interference with this stress response

81 nd herpesviruses, in large part due to viral latency and the evolution of resistance to existing ther

82 The latency and the precision in the latency of the SLC fiel

83 iptional program associated with herpesvirus latency and the viral genes regulating entry into and ex

84 e sleep diary-derived values for sleep-onset latency and wake after sleep onset, collected prospectiv

85 rophages directly reduce the levels of HSV-1 latency and, thus, T-cell exhaustion in the TG of ocular

86 wrist (i.e. median sensory nerve conduction latency) and in the brain (i.e. digit 2/3 cortical separ

87 nced normal thresholds, decreased activation latencies, and larger amplitudes compared with WT mice.

88 age showed less precise saccades with longer latencies, and more frequent directional errors, usually

89 Based on their high penetrance, short latency, and histologic fidelity, these models of papill

90 persistence, involving productive infection, latency, and intermittent reactivation.

91 ir progenitors are an important site of HCMV latency, and one viral gene expressed by latently infect

92 KLF15, are induced during reactivation from latency, and they stimulate certain viral promoters and

93 cellular metabolic pathways are required for latency, and we now show that these metabolic pathways a

94 ased virus replication in the eye; increased latency; and also increased CD4, CD8, IFN-gamma, and PD-

95 A blood polyfunctional, Mtb DosR latency antigen specific, regulatory, central memory res

96 cular early secreted versus dormancy related latency antigens expressed later, that distinguish subje

97 ses to host stress and mechanisms leading to latency are critical for persistence.

98 al genes regulating entry into and exit from latency are poorly understood and controversial.

99 and inter-observer ( >/=70%) reliability for latency, area-under-the-curve and peak-to-peak amplitude

100 riable escape responses with relatively long latencies as well as the unilateral recruitment of ventr

101 DNA as extra-chromosomal episomes, express 9 latency-associated EBV proteins, and phenotypically rese

102 Latency-associated nuclear antigen (LANA) is a conserved

103 Latency-associated nuclear antigen (LANA) is a multifunc

104 The latency-associated nuclear antigen (LANA) of the Kaposi'

105 HV establishes lifelong infections using its latency-associated nuclear antigen (LANA).

106 c patch-binding proteins such as herpesvirus latency-associated nuclear antigen (LANA).

107 IE1/IE2 mRNA while curbing the expression of latency-associated UL138 mRNA.

108 Three related latency-associated viral proteins EBNA3A, EBNA3B, and EB

109 igh burden of morbidity, coupled with a long latency between BMT and the development of chronic healt

110 so potently stimulated HSV reactivation from latency both in a sensory ganglia model system and in vi

111 In contrast, longer-latency brain activity was specifically sensitive to tra

112 nses specific to Mtb dormancy related (DosR) latency, but not classical immunodominant secretory anti

113 parasites is thought to undergo ART-induced latency, but the mechanisms remain unknown.

114 port for the hypothesis that miR-H2 promotes latency by inhibiting ICP0 expression, the possibility r

115 Naf1 contributes to the maintenance of HIV-1 latency by inhibiting LTR-driven HIV-1 gene transcriptio

116 iscrimination between short-latency and long-latency C-starts (SLCs vs. LLCs) in larval zebrafish.

117 sed dsTMS to systematically investigate long-latency causal interactions between right-hemisphere mot

118 Strikingly, TIPRL and the latency chaperone, alpha4, coordinate to disassemble act

119 that the inhibitory st-LFP peaked at shorter latencies, consistently with previous findings in hippoc

120 lso significantly related to visual response latency, contrast sensitivity (C-50 values), directional

121 thesize that viral products expressed during latency cooperate with neuronal factors to maintain late

122 cies regardless of stimulation intensity, MC latencies correlate negatively with stimulation intensit

123 ex d = 2.32 [95% CI, 2.01-2.63], sleep-onset latency d = 1.41 [95% CI, 1.15-1.68], and wake after sle

124 of TAO patients with DON showed delayed P100 latencies, decreased P100 amplitudes or delayed N75 late

125 astine fumarate treatment, which reduced the latency delay by 1.7 ms/eye (95% CI 0.5-2.9; p=0.0048) w

126 The primary outcome was shortening of P100 latency delay on full-field, pattern-reversal, visual-ev

127 e repression of lytic gene expression during latency deserve investigation.

128 illi), (ii) sample size (QB waveform), (iii) latency distribution (time delay between photon arrival

129 rack of the target, on top of inducing short latency disturbance of grip force, single-pulse TMS shou

130 es, decreased P100 amplitudes or delayed N75 latencies during pVEP, compared to those without or heal

131 a behaviorally selective engagement of short-latency effector pathways.

132 pletely suppressed the elongation of seizure latency elicited by DHA.

133 dependent tuning of exocytosis: accurate low-latency encoding of onset and offset of sound intensity

134 Herpes simplex virus 1 (HSV-1) latency entails the repression of productive ("lytic") g

135 M facilitates replication, reactivation, and latency establishment of several gammaherpesviruses in v

136 hat LANA is important for acute replication, latency establishment, and reactivation in vivo Despite

137 at low frequencies (</=1 Hz) evoked a short-latency excitation of BA interneurons (INs) that was dep

138 cancer risk, even after considering several latency exposure classifications.

139 riness and superexcitability of the shortest latency (fast, F) nerve fibres, consistent with hyperpol

140 ng the most effective dose and dose-response latency for targeting the amygdala.

141 we observed fewer evoked spikes with longer latencies from stimulus onset.

142 er, these findings indicate that first spike latency (FSL) is a fast encoding mechanism that can serv

143 time of the first evoked spike (first spike latency; FSL) and the number of evoked spikes.

144 ) depletion of TET2 results in a decrease in latency gene expression but can also trigger a switch to

145 ipts are regulated similarly to EBV type III latency genes and that TET2 protein is a cofactor of EBN

146 BV), EBV type 1 (EBV-1) and EBV-2, differ in latency genes, suggesting that they use distinct mechani

147 n patterns that restrict expression of viral latency genes.

148 ing and clearing the rare cells in which HIV latency has been reversed.

149 Studies of HIV-1 latency have focused on regulation of viral gene express

150 I latency, versus the more restricted type I latency, have not been well characterized.

151 ent with PLEX was not associated to PML-IRIS latency (hazard ratio [HR] = 1.05; p = 0.92), but once I

152 highly transforming form (type III) of viral latency; however, long-term EBV infection in immunocompe

153 LANA protein is capable of supporting MHV68 latency in a mouse model of chronic infection but also f

154 idelalisib.IMPORTANCE EBV establishes viral latency in B cells.

155 no terminus of ORF2 does not reactivate from latency in calves.

156 ed for the successful establishment of viral latency in CD34(+) cells, as pharmacological inhibition

157 ruses preferentially replicate and establish latency in different subtypes of sensory neurons, as wel

158 ssential for alphaherpesviruses to establish latency in ganglia and then to reactivate and move back

159 rpesviruses is the establishment of lifelong latency in host sensory ganglia with occasional reactiva

160 es describe a novel model for studying HIV-1 latency in human primary cells maintained in a quiescent

161 llowing orofacial infection, HSV establishes latency in innervating sensory neurons, primarily locate

162 stigated the potential role of TREM-1 in HIV latency in macrophages.

163 r infection by EBV, thus favouring long-term latency in MBC and asymptomatic persistence.

164 e unable to enter into neurons and establish latency in mice, can be utilized as a vector for the het

165 evolved to efficiently infect and establish latency in neurons.

166 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can react

167 characterize a novel in vitro model of HIV-1 latency in primary hematopoietic stem and progenitor cel

168 ortant bovine pathogen, establishes lifelong latency in sensory neurons.

169 acute infection, BoHV-1 establishes lifelong latency in sensory neurons.

170 shorter EPSP-AP delay in vivo and shorter AP latency in slice experiments, is consistent with increas

171 mice, KLKI MHV68 established and maintained latency in splenocytes and peritoneal cells but did not

172 aimiri, a gamma-herpesvirus that establishes latency in the T cells of New World primates and has the

173 ciated with the establishment or reversal of latency in the target cells.

174 er reducing HSV-1 replication in the eye and latency in the TG by modulating immune components, speci

175 ss potentiated the formation and reduced the latency in tumor development.

176 ight sensitivity, millisecond-scale response latency in vivo, as well as adjustable channel off laten

177 ation resulting in extended leukemic disease latency in vivo.

178 results in a quiescent infection resembling latency in which viral genomes are retained in a low num

179 cation of exosome in the reactivation of HIV latency, in combination its use as functional delivery v

180 Viral latency, in which a virus genome does not replicate inde

181 CG feedback reduced visually evoked response latencies, increased spike-timing precision, and reduced

182 ing to repression of general translation and latency induction.

183 is unclear, although it is known that type I latency is associated with a germinal center (GC) B cell

184 HIV-1 latency is characterized by reversible silencing of vira

185 HIV-1 latency is characterized mainly by a reversible silencin

186 The biology of HIV latency is complex and incompletely understood.

187 Viral latency is established when the expression of the autore

188 Reactivation from latency is initiated by the synthetic corticosteroid dex

189 Latency is the most biologically interesting and clinica

190 ls, both first-spike latency and first-spike latency jitter increased, while spontaneous and evoked f

191 During latency, LANA localizes to discrete punctate spots in th

192 During latency, LANA localizes to the nucleus, where it connect

193 Persistence during latency-like conditions required kinase activity and thi

194 veled novel functional facets of PknG during latency-like conditions.

195 flanked by boundary elements from the viral latency locus showed high, persistent reporter gene acti

196 Recent research has identified late-latency, long-lasting neural activity as a robust correl

197 interference effect was observed with naming latencies longer in HOM versus HET blocks.

198 by KSHV to maintain latent infection, (ii) a latency-lytic cycle switch operated by K-Rta, and (iii)

199 he higher proportion of more costly, shorter-latency Mauthner-active responses to greater perceived t

200 infected cells and that true transcriptional latency may not be possible in vivo, especially in the p

201 trinsic noise components, which include bump latency (mean delay and jitter) and shape (amplitude and

202 Our results reveal that the specific latency mechanism of Kgp differs from those of Rgps.

203 nical infection, validating our experimental latency model.

204 In cell lines, including HIV-1 latency models, increased HIV-1 production was observed,

205 NK in HIV-infected cells across two in vitro latency models.

206 and multiple system atrophy in 1) with mean latency of 3.2 +/- 1.9 years from imaging.

207 sting membrane potential, and decreasing the latency of action potentials triggered by depolarization

208 Transcriptional latency of HIV is a last barrier to viral eradication.

209 ion of Setd2 in a murine model decreased the latency of MLL-AF9-induced leukemia and caused resistanc

210 ross the visual field; asymmetry in the peak latency of the early N2c target-selection signal; and, f

211 We showed that visual latency of the LFP preceded spiking activity in the visu

212 d cortical activity from that related to the latency of the response to sound onset, which is found i

213 The latency and the precision in the latency of the SLC field potentials were linearly correl

214 lly, TC-PTP knockout mice showed a shortened latency of tumorigenesis and significantly increased num

215 ear is why antipsychotics have a therapeutic latency of weeks.

216 rus to persist may result from either a true latency or sequestration in an anatomic site that is not

217 However, despite serial reversal of latency over 1 month of VOR dosing, we did not observe a

218 electrical stimulation indicated that short-latency pathways linking motor cortex with spinal motor

219 re found to be inversely correlated with the latency period (and thus predict the onset of seizures)

220 The median latency period at diagnosis (or first suspicion of a PHD

221 median age of 12 years (3-35 years), with a latency period of 9.5 years (2.5-34 years).

222 ro-oncogenic molecular events throughout the latency period of disease progression.

223 The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesi

224 changes drive carcinogenesis during the long latency period of mesothelioma development and shows tha

225 Given the long latency period of pancreatic cancer, exploring the influ

226 bility of generating triggered activity, the latency period variance and SR Ca load had the greatest

227 enesis assessments were taken after 15 weeks latency period.

228 ling in the rate of leukemia, with a reduced latency period.

229 of EBNA2 and coregulator of the EBV type III latency program and DNA methylation state.IMPORTANCE Eps

230 The diversity of the latency protein EBV nuclear antigen leader protein (EBNA

231 cilitating the development of antivirals and latency reactivating agents.

232 ies treating HIV-1-infected individuals with latency reactivation agents to reduce their latent HIV-1

233 aling pathway is regulated during the BoHV-1 latency-reactivation cycle (Y.

234 ppears to mediate important steps during the latency-reactivation cycle because a mutant virus contai

235 sensory neuron (OSN) stimulation with short latencies regardless of stimulation intensity, MC latenc

236 The latency-related (LR) RNA encoded by bovine herpesvirus 1

237 load, V0 ) is already set at the end of the latency relaxation (LR) preceding isometric force genera

238 velocity (V0 ) is already set at the end of latency relaxation (LR), approximately 10 ms after the s

239 Viral latency remains the most significant obstacle to HIV era

240 est that EBV-2 uses T cells as an additional latency reservoir but that, over time, the frequency of

241 us human gammaherpesvirus that establishes a latency reservoir in B cells.

242 In latency reservoirs, such as B lymphocytes, gammaHVs exis

243 Here, we find that longer-latency responses in mitral cells, compared with tufted

244 -flash cone b-wave latency and 30-Hz flicker latency responses were significantly delayed bilaterally

245 ation drives proliferation but also reverses latency, resulting in productive infection that generall

246 Analysis at longer latencies revealed a positive component (corresponding t

247 When seven different classes of latency reversal agents (LRA) in resting CD4(+) T cells

248 is a key part of current efforts to develop latency reversal and viral clearance strategies to eradi

249 In addition to improvements in latency reversal, these advances may include the sustain

250 Treatment with latency reversing agents (LRAs) enhances human immunodef

251 Several latency reversing agents (LRAs) have been examined in vi

252 dministration of synergistic combinations of latency reversing agents (LRAs), such as histone deacety

253 Stimulation with CD3/CD28, PMA/ionomycin, or latency reversing agents prostratin and SAHA, yielded in

254 us treatment of HIV-1-infected patients with latency-reversing agents (LRAs) and combination antiretr

255 strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent

256 cial to identifying and developing effective latency-reversing therapies.

257 By building upon previous progress in latency reverting agents, our compound appears to provid

258 Latency-reverting agents that can perform the "kick" fun

259 sleep quality; total sleep time, sleep onset latency, sleep efficiency, and awake after sleep onset,

260 between primary SLCs and less frequent, long-latency startle responses (LLCs).

261 Here, we examined short-latency startle responses (SLCs) in larval zebrafish and

262 arn how virus maintains and reactivates from latency, studies are done in neurons taken from rodents

263 wed by another population of responses whose latencies systematically decreased at higher concentrati

264 n [5-7] and ablating M-cells abolishes short-latency tail-elicited startles [8, 9], we hypothesized t

265 e resistant to spontaneous reactivation from latency than more differentiated HSPCs and that quiescen

266 tion-invariant units respond earliest and at latencies that are within this behaviorally-defined time

267 virus (KSHV) encodes 12 pre-microRNAs during latency that are processed to yield 25 mature microRNAs

268 mune deficient mice (huNSG) results in viral latency that can be reactivated following G-CSF treatmen

269 Basic virus dynamics models of latency that do not take into account pyroptosis, superi

270 ral replication proteins is a unique form of latency that may promote chronic viral persistence for s

271 Developing in vitro models of HIV-1 latency that recapitulate the characteristics of latentl

272 NX3/CBF during B cell transformation and EBV latency that was hitherto unexplored.

273 l parameters revealed that, apart from their latencies, they were intensity independent.

274 Protein-mediated viral latency through cellular SCF E3 ligase targeting of vira

275 However, the latency to ethanol-induced loss of righting reflex incre

276 nd tail suspension tasks, as well as reduced latency to feed in the novelty suppressed feeding test.

277 studies suggested that the KSHV switch from latency to lytic replication is primarily controlled at

278 uccessful chickadee flocks, furthermore, the latency to obtain seed from the novel feeder was shorter

279 We found that, while the response latency to visual stimulus onset was earlier for V1 neur

280 peared more anxious, as indicated by a short latency to vocalize when faced with a novel object task.

281 DNA demethylation, is a key regulator of EBV latency type DNA methylation patterning.

282 nal silencing similar to what is seen in EBV latency type III genomes.

283 -hydroxymethylcytosine (5hmC), regulates EBV latency type in B cells by enhancing the ability of the

284 How EBV converts latency type is unclear, although it is known that type

285 ed to B cells with a more restricted form of latency (type I) in which most viral gene expression is

286 EBV latency types are defined by DNA methylation patterns th

287 recovery of affected optic nerve conduction latency using full-field visual evoked potential (FF-VEP

288 han did typically developing children; their latency varied neither categorically nor dimensionally b

289 EBV enters the highly transforming type III latency, versus the more restricted type I latency, have

290 A significant decrease in response latency was also found between stimulations, and each st

291 This increase in gaze latency was due to a decrease in velocity and amplitude

292 dels developed high-penetrance AML, although latency was significantly longer with Npm1(cA/+);Nras(G1

293 rtical input layer 4, and sound-evoked spike latencies were longer in layer 4 than in subplate, consi

294 orphism at codon 132 can markedly extend CWD latency when the minor leucine allele (132L) is present.

295 into the effects of host modulation on HIV-1 latency, which may lead to a potential therapeutic strat

296 increasing stimulus intensity decreased SLC latencies while increasing their precision, which was si

297 l center (GC) B cell phenotype, and type III latency with an activated B cell (ABC) phenotype.

298 imals and a progressive decrease in response latency with development.SIGNIFICANCE STATEMENT Orientat

299 HSV-1 establishes latency within sensory neurons of trigeminal ganglia (TG

300 Herpes simplex virus 1 (HSV-1) establishes latency within the sensory neurons of the trigeminal gan