ライフサイエンスコーパス: latency-associated transcript

1 reverse transcription-PCR detection of HSV-1 latency-associated transcripts).

2 encoded within the second exon of the HSV-1 latency-associated transcript.

3 ined expression of four previously described latency-associated transcripts.

4 latently infected neurons is limited to the latency-associated transcripts.

5 res of latent infection, including classical latency-associated transcripts, a punctate pattern of LA

6 At 48 and 72 h, although latency-associated transcripts accumulated to comparable

7 aracterized by the expression of a noncoding latency-associated transcript and a set of microRNAs.

8 similar to those of WT virus, the levels of latency-associated transcript and micro-RNAs were 50- to

9 egalovirus is accompanied by the presence of latency-associated transcripts and expression of immunog

10 We used RT-PCR to detect latency-associated transcripts and HSV-1 lytic cycle gen

11 me loads and exhibited reduced expression of latency-associated transcripts and reduced reactivation

12 d to support latency and expression of viral latency-associated transcripts and to undergo reactivati

13 nsory neurons in which only noncoding (e.g., latency-associated transcript) and micro-RNAs are expres

14 hich do not accumulate significant levels of latency-associated transcripts, and (iii) the activation

15 pes simplex virus, which is characterized by latency-associated transcripts, and from lytic VZV repli

16 n used as a model for latency; viral DNA and latency-associated transcripts are expressed in dorsal r

17 ome, corresponding to the 5' end of the LAT (latency-associated transcript) coding region, is respons

18 yed to study the effect of a deletion in the latency-associated transcript domain.

19 e percentage of neurons expressing the major latency-associated transcript during the latent infectio

20 genitors is characterized by the presence of latency-associated transcripts encoded in the ie1/ie2 re

21 root ganglia were positive for HSV-2 DNA and latency-associated transcripts for 5/8 animals in the gC

22 utilized by the herpes simplex virus type 1 latency-associated transcript in latently infected mice

23 Marek's disease virus (MDV) latency-associated transcripts include at least two MDV

24 alternative promoter usage by LMP2 and other latency-associated transcripts, intergenic splicing at t

25 tion of sensory ganglia of mice, in that HSV latency-associated transcript is expressed, but to be de

26 d to inoculate rabbit corneas: 17deltaPst, a latency associated transcript (LAT) negative, low-reacti

27 viral gene product is a non-coding RNA, the latency associated transcript (LAT).

28 In the presence of latency-associated transcript (LAT((+)); wt virus), CD8(

29 ese, miR-H7 and miR-H9, are derived from the latency-associated transcript (LAT) and are located anti

30 Finally, the copy numbers of latency-associated transcript (LAT) and CD4(+) and CD8(+

31 in the HSV-1 genome, specifically around the latency-associated transcript (LAT) and ICP0 and ICP4 re

32 HSV-2 latency-associated transcript (LAT) contains a cis-actin

33 ation of herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) expression and proce

34 stitution of a 2.8-kbp region from the HSV-1 latency-associated transcript (LAT) for native HSV-2 seq

35 s study, a chimeric HSV-2 that expressed the latency-associated transcript (LAT) from HSV-1 reactivat

36 s of deletions in the promoter region of the latency-associated transcript (LAT) gene in impairing he

37 Expression of the latency-associated transcript (LAT) gene is a hallmark o

38 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential fo

39 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential fo

40 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential fo

41 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential fo

42 productive ("lytic") infection, but only the latency-associated transcript (LAT) gene is expressed at

43 The latency-associated transcript (LAT) gene is required for

44 The latency-associated transcript (LAT) gene the only herpes

45 t of the herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene to analyze its

46 The HSV-1 latency-associated transcript (LAT) gene, the only viral

47 To determine the role of the latency-associated transcript (LAT) in inhibiting apopto

48 We next examined the role of latency-associated transcript (LAT) in spontaneous gangl

49 the amount of CS and the level of the HSV-1 latency-associated transcript (LAT) in trigeminal gangli

50 The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis.

51 indicated that the unusual stability of the latency-associated transcript (LAT) intron was due to it

52 m, the major transcript detected is the 2-kb latency-associated transcript (LAT) intron.

53 The herpes simplex virus type 1 (HSV-1) 2-kb latency-associated transcript (LAT) is a stable intron,

54 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is abundantly expres

55 The latency-associated transcript (LAT) is essential for the

56 The latency-associated transcript (LAT) is required for effi

57 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only abundant

58 The latency-associated transcript (LAT) is the only abundant

59 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only HSV-1 ge

60 l ganglia when only the transcription of the latency-associated transcript (LAT) locus is detected.

61 er cassette, when placed in the context of a latency-associated transcript (LAT) null mutant, resulte

62 The latency-associated transcript (LAT) of herpes simplex vi

63 The latency-associated transcript (LAT) of herpes simplex vi

64 Only the latency-associated transcript (LAT) of the herpes simple

65 ER and dlsptk expressed higher levels of the latency-associated transcript (LAT) per genome earlier i

66 fluence latency-associated transcription and latency-associated transcript (LAT) phenotypes, we studi

67 The HSV-1 latency-associated transcript (LAT) plays a major role i

68 and HSV-2) establish latency and express the latency-associated transcript (LAT) preferentially in di

69 udies have demonstrated that histones in the latency-associated transcript (LAT) promoter and intron

70 A previous study demonstrated that the latency-associated transcript (LAT) promoter and the LAT

71 ownstream of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter and upstrea

72 Latency-associated transcript (LAT) promoter deletion mu

73 e herpes simplex virus type 1 (HSV-1) or the latency-associated transcript (LAT) promoter deletion mu

74 primary herpes simplex virus type 2 (HSV-2) latency-associated transcript (LAT) promoter influences

75 The latency-associated transcript (LAT) promoter of herpes s

76 he murine IL-2 gene under the control of the latency-associated transcript (LAT) promoter of HSV-1 in

77 designated miR-H6 is located upstream of the latency-associated transcript (LAT) promoter region on t

78 acted from whole ganglia, (ii) the number of latency-associated transcript (LAT) promoter-positive ne

79 HSV, we have shown previously that the viral latency-associated transcript (LAT) promotes lytic gene

80 Recent studies have suggested that the latency-associated transcript (LAT) region of herpes sim

81 k the meq oncogene and three that map to the latency-associated transcript (LAT) region of the genome

82 ganglia (DRG), chromatin associated with the latency-associated transcript (LAT) region of the viral

83 ne, and a second cluster is found within the latency-associated transcript (LAT) region.

84 The latency-associated transcript (LAT) regulates the establ

85 The percentage of latency-associated transcript (LAT) RNA-positive neurons

86 Latency-associated transcript (LAT) sequences regulate h

87 I, encoded by herpes simplex virus 2 (HSV-2) latency-associated transcript (LAT) through small RNA cl

88 Further analysis confirmed that this SVV latency-associated transcript (LAT) was oriented antisen

89 In particular, the transcription of the latency-associated transcript (LAT), IE genes, and genes

90 During latency only one locus, the latency-associated transcript (LAT), is abundantly trans

91 addition, we show that in the absence of the latency-associated transcript (LAT), the latent genome s

92 Latency-associated transcript (LAT), the only known vira

93 Interestingly, latency-associated transcript (LAT), the only viral gene

94 ross talk appears to occur between the HSV-1 latency-associated transcript (LAT), the only viral gene

95 tream of the transcription start site of the latency-associated transcript (LAT), were detected durin

96 anglia, HSVs express a long noncoding RNA, a latency-associated transcript (LAT), which plays a key r

97 a harvested during HSV latency, 25% of HSV-1 latency-associated transcript (LAT)- and 4% of HSV-2 LAT

98 sed to examine the role of the cornea in the latency-associated transcript (LAT)-mediated reactivatio

99 Herpes simplex virus type 1 latency-associated transcript (LAT)-null mutants have de

100 ular inoculation with HSV strain KOS, 81% of latency-associated transcript (LAT)-positive trigeminal

101 tional copies of the gK gene in place of the latency-associated transcript (LAT).

102 f key HSV-1 genes, including ICP0, ICP4, and latency-associated transcript (LAT).

103 ctively transcribed: the region encoding the latency-associated transcript (LAT).

104 pression is tightly repressed except for the latency-associated transcript (LAT).

105 ing the gene for murine IL-4 in place of the latency-associated transcript (LAT).

106 The latency-associated transcripts (LAT) family members are

107 herpes simplex virus type 1 (HSV-1) DNA and latency-associated transcripts (LAT) in the latently inf

108 ive by in situ hybridization (ISH) for HSV-1 latency-associated transcripts (LAT), the classical surr

109 erized by the constitutive expression of the latency-associated transcripts (LAT), which originate fr

110 expressed HSV-1 protein and 13.1% expressed latency-associated transcripts (LAT).

111 fection, viral gene expression is limited to latency-associated transcripts (LAT).

112 pression of viral gene expression except for latency-associated transcripts (LATs) and miRNAs.

113 latently infected ganglia is reduced by the latency-associated transcripts (LATs) and whether splici

114 These latency-associated transcripts (LATs) are derived from t

115 e expression is severely repressed; only the latency-associated transcripts (LATs) are expressed abun

116 and HSV-2 also preferentially express their latency-associated transcripts (LATs) in different senso

117 s type 1 is required to generate a series of latency-associated transcripts (LATs) in sensory neurons

118 sly, we documented the focal presence of the latency-associated transcripts (LATs) in the hippocampi

119 detectable viral proteins, expression of the latency-associated transcripts (LATs) is likely regulate

120 The latency-associated transcripts (LATs) of herpes simplex

121 of HSV genes and accumulation of the stable latency-associated transcripts (LATs), as occurs in neur

122 1 and -2 to establish latency and to express latency-associated transcripts (LATs), virulent strains

123 onally active, producing the 2.0- and 1.5-kb latency-associated transcripts (LATs).

124 of both the gamma(1)34.5 transcripts and the latency-associated transcripts (LATs).

125 ue, the only abundant viral products are the latency-associated transcripts (LATs).

126 n limited to a single locus that encodes the latency-associated transcripts (LATs).

127 re detected by in situ hybridization for HSV latency-associated transcripts (LATs).

128 ries of 5' coterminal transcripts termed the latency-associated transcripts (LATs).

129 gene expression is largely restricted to the latency-associated transcripts (LATs).

130 rpes simplex virus expresses a unique set of latency-associated transcripts (LATs).

131 type 1 gene expression is restricted to the latency-associated transcripts (LATs).

132 cription of viral genes is restricted to the latency-associated transcripts (LATs).

133 In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequ

134 Latency-associated transcript ORF 73 was unaffected by t

135 se two viruses are within or proximal to the latency-associated transcript region.

136 These, along with the latency-associated transcript, represent the only viral

137 ICP4, thymidine kinase, glycoprotein C, and latency-associated transcript RNA by in situ hybridizati

138 mice, as determined by the expression of the latency-associated transcript RNAs.

139 LAT (latency-associated transcript), the only known viral gen

140 iral genome became relatively quiescent, the latency-associated transcript was specifically upregulat

141 Expression of HSV-1 latency-associated transcripts was noted in TG cell cult

142 : sense and antisense meq, ORF L1, ICP4, and latency-associated transcripts, which are antisense to I

143 ve (NgK) form of the gK gene in place of the latency-associated transcript with a myc epitope tag to