ライフサイエンスコーパス: latent

1 ains unclear how infection initially becomes latent.

2 ronic infection due to its ability to become latent.

3 er reaction sequence employs nitroalkenes as latent 1,2-dication synthons providing a novel access to

4 es a remarkable conformational change from a latent 6beta-stranded form that diffuses in the cytoplas

5 study of the craniofacial nervous system and latent alphaherpesvirus infections.

6 losis-infected nonhuman primates during both latent and active disease.

7 llular m(6)A/m epitranscriptomes during KSHV latent and lytic infection.

8 ar distribution, and how these may differ in latent and lytic KSHV infections are poorly understood.

9 KS tumors support both latent and lytic KSHV replication.

10 ative demands placed upon the protein in the latent and lytic phases.IMPORTANCE The K15P protein of K

11 's sarcoma-associated herpesvirus (KSHV) has latent and lytic replication phases that are essential f

12 ontain abundant m(6)A/m modifications during latent and lytic replication, and these modifications ar

13 demands placed upon the protein in the viral latent and lytic stages.

14 We used generalized linear latent and mixed methods to model the effects of DWS on

15 partment.IMPORTANCE HHV-8 vIL-6 prosurvival (latent) and proreplication functions are mediated from t

16 l expression programs (i.e., between active, latent, and abortive fates).

17 ked immunosorbent assays-both HHV8 lytic and latent antigen based) and 2 molecular assays were used.

18 Cas9 protein were successfully tested on HIV latent astrocytes without Cas9 expression to mimic clini

19 association model, disease risk depends on a latent bipartition of rare variants into pathogenic and

20 treating chronic infections and eliminating latent bradyzoites in the brain.

21 lling on 341 older adults to establish three latent brain factors (amygdala, pACC and dorsolateral pr

22 ly, BORG elicits the metastatic outgrowth of latent breast cancer cells by promoting the localization

23 n NZ sea lion pup production is explained by latent by-catch, and the population would increase witho

24 inferred to have been generated by the same latent cause.

25 rience into statistically distinct clusters (latent causes).

26 Clinical strategies aim to purge the latent CD4+ T cell reservoir by activating viral express

27 he two fields, and highlights where there is latent chemical space for collaborative exploration by t

28 We treat heterogeneity as a latent class allocation problem and present a covariate

29 tended elements of attributable fraction and latent class analyses to meet some of these challenges a

30 The latent class analysis model with the best fit to PASTURE

31 uantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model.

32 Latent class analysis shows that African American males

33 The latent class analysis was used to identify subtypes of a

34 iptive, case-control, attributable fraction, latent class analysis) address some but not all challeng

35 Using latent class analysis, 4 phenotypes of atopic dermatitis

36 atterns to determine menopausal status using latent class analysis.

37 EOs across the day, were determined by using latent class analysis.

38 na; therefore, we trialed the application of latent class and latent transition models to HIV surveil

39 udinal modeling approach in conjunction with latent class estimation to adjust for unmeasured sources

40 Latent class growth analysis was applied to longitudinal

41 ivity throughout childhood, identified using latent class growth modeling.

42 Applying latent class linear mixed modeling on individuals' patte

43 By applying latent class linear mixed modeling on individuals' patte

44 The latent class model did not successfully predict treatmen

45 A Bayesian latent class model was constructed on the basis of demog

46 In the latent-class analysis, the highest-order maternal weight

47 We used latent-class growth modeling in addition to national rec

48 maternal weight trajectories based on either latent-class results or recommendations showed that the

49 Six latent classes were identified, representing subphenotyp

50 ight overwhelm natural buffering and amplify latent climate signals, rendering them detectable.

51 omer, pro-TGF-beta is secreted and stored in latent complexes.

52 The severe phenotype emerged as a latent condition with signs of a dysbalanced immune resp

53 d the challenges of accurately measuring the latent construct of cognitive reserve.

54 Stg/+ mice, therefore, have a latent cortical network phenotype that is veiled by NMDA

55 ling inflationary effector responses against latent cytomegalovirus with only limited evidence of exh

56 MP activity across the entire skin reveals a latent dermal capacity to undergo spatially patterned se

57 ctory and the spontaneous reacquisition of a latent, developmentally encoded epigenetic landscape.

58 e Document Frequency in the bag-of-words and Latent Dirichlet Allocation in the topic modeling catego

59 Using the Latent Dirichlet Allocation method, we disentangle studi

60 a polygenic method, which we refer to as the latent Dirichlet process regression model.

61 arametric genetic prediction method based on latent Dirichlet Process regression models.

62 Younger age, latent disease status, and access to care at a regional

63 tes was best modelled jointly using a single latent dynamic factor for local trends, with the inclusi

64 ations in EBV genes including genes encoding latent, early lytic, and tegument proteins, such as subs

65 s a means to facilitate the establishment of latent EBV infection and enhance viral replication.

66 Preclinical literature suggests latent effects of early life adversity on serotonin func

67 articularly attractive as a means to explore latent electrophiles not typically used in medicinal che

68 essive, metastatic disease by reactivating a latent embryonic programme: epithelial-to-mesenchymal tr

69 tions in early steps of mismatch repair as a latent endonuclease that requires a mismatch, MutSalpha/

70 posi's sarcoma-associated herpesvirus (KSHV) latent episomes are poised to be activated by the KSHV r

71 odel of organizational accidents, active and latent errors coincided to contribute to the pseudo-outb

72 Our findings suggest that EL is driven by a latent evidence accumulation process that can be reveale

73 Sparse latent factor models, assuming activity of transcription

74 Using latent factor models, we identified developmental change

75 ional motivation are underpinned by the same latent factor.

76 sistency as an existence of a pixel-specific latent feature vector and a spectrum-specific projection

77 istency is then measured using the number of latent feature vectors required to reconstruct the repre

78 ectrometry imaging (DESI-MSI) was applied to latent fingerprints to obtain not only spatial patterns

79 o the ability of the virus to persist in the latent form for the lifetime of the host.

80 ams can make memories quiescent, stored in a latent form that is available for context-relevant activ

81 oordinates to map a real network back to its latent geometry remains a challenging inverse problem.

82 ex systems favors the application of network latent geometry techniques in disciplines dealing with b

83 nally developed as a new platform for active-latent glycosylations.

84 Latent growth mixture modeling was applied to identify g

85 Using latent growth mixture modeling, trajectories of PTSD sym

86 romedial prefrontal cortex (PFC) tracked the latent growth of cumulative economic outcomes.

87 exchange across the solid-liquid interface, latent heat exchange, local thermal gradients, and the G

88 rticular if it was associated with erroneous latent heat flux estimates.

89 The melting temperatures and latent heat of CPCMs are in the range of 52-55 degrees C

90 ansport charging mechanism and the increased latent heat storage through magnetic manipulation of the

91 state-of-the-art thermal storage due to high latent heat.

92 positive feedback related to condensational latent heating over the rainforest, which strongly enhan

93 gest that macrophages are key reservoirs for latent HIV even in individuals on antiretroviral therapy

94 ible assay to quantify replication-competent latent HIV in resting CD4(+) T cells, both increasing ac

95 ing developed to accelerate the decay of the latent HIV reservoir, it will be important to identify i

96 prevent expansion and/or repopulation of the latent HIV reservoir.

97 (SRM-MS) is sufficiently sensitive to detect latent HIV reservoirs following reactivation of virus.

98 r have focused on inducing the expression of latent HIV so that infected cells may be recognized and

99 ck and kill" strategy proposes "kick" of the latent HIV to an active HIV to eventually be "killed".

100 used to combat the problems associated with latent HIV virus re-emergence in patients.

101 o undetectable levels but does not eliminate latent HIV, thus necessitating lifelong therapy.

102 ly quantify inducible, replication-competent latent HIV-1 from resting CD4(+) T cells is essential fo

103 that exosomes from uninfected cells activate latent HIV-1 in infected cells and that true transcripti

104 IV-1 eradication require the reactivation of latent HIV-1 in resting CD4+ T cells (rCD4s).

105 result with implications for elimination of latent HIV-1 infection by T cell-based vaccines.

106 Establishment of latent HIV-1 infection in CD4(+) T could be inhibited by

107 icularly permissive for the establishment of latent HIV-1 infection.

108 at recognizes H4K20me1, was recruited to the latent HIV-1 promoter in a SMYD2-dependent manner.

109 equencing (ATAC-seq) data, we found that the latent HIV-1 promoter phenotypically resembles endogenou

110 induced marked nucleosome remodeling at the latent HIV-1 promoter, which was dependent on the activi

111 ssay, we show that the size of the inducible latent HIV-1 reservoir in aviremic participants on thera

112 The latent HIV-1 reservoir represents the major barrier for

113 latency reactivation agents to reduce their latent HIV-1 reservoirs indicated that their HIV-1-speci

114 their recruitment paradoxically reactivates latent HIV-1 transcription.

115 CC may facilitate elimination of reactivated latent HIV-1-infected cells to deplete the HIV-1 reservo

116 ent to effectively eliminate the reactivated latent HIV-1-infected T cells.

117 to quantify inducible, replication-competent latent HIV-1.

118 we explored the acute signaling response of latent HIV-infected CD4+ T cells to identify dynamic pho

119 eactivation improves strategies to eliminate latent HIV.

120 dding, low lesion scores, and a reduction in latent HSV-2 DNA in dorsal root ganglia to undetectable

121 r the occurrence of repeated reactivation of latent HSV1 in the brain in AD pathogenesis are also dis

122 ease progression into a thermal effect and a latent immunocompetence effect (driven by nonthermal env

123 ial infection, the virus remains inactive or latent in nerve cells that sense the region where that i

124 the proportion of infections that were early latent increased from 27% to 44% (Ptrend < .0001), while

125 provide insight into the maintenance of KSHV latent infection and the switch to lytic replication.

126 Both latent infection and viral protein expression contribute

127 Strategies to eradicate latent infection can only be evaluated with robust, sens

128 uripotency, plays a role in maintaining KSHV latent infection in naturally infected cells.

129 n of viral gene expression in cells in which latent infection is established.

130 LAcmvIL-10 is also expressed during latent infection of myeloid progenitor cells and monocyt

131 hether TB disease was due to reactivation of latent infection or a result of recent transmission, nor

132 were substantially more permissive for HIV-1 latent infection than other CD4(+) T cells.

133 pstein-Barr virus (EBV) establishes a stable latent infection that can persist for the life of the ho

134 le decrease (>0.3 log10) in the frequency of latent infection within resting CD4+ T cells.

135 (i) a mechanism utilized by KSHV to maintain latent infection, (ii) a latency-lytic cycle switch oper

136 CMV, a herpesvirus that causes a persistent/latent infection, and vaccinia virus, a poxvirus that is

137 During latent infection, EBV encodes latent membrane protein 2A

138 ed cells shows the properties expected for a latent infection, including reactivation to produce newl

139 episomes inside the host cell nucleus during latent infection.

140 ymphocyte pool through a growth-transforming latent infection.

141 ers for the experimental use of VOR to clear latent infection.

142 ation-mediated transmission, reactivation of latent infections in an immunosuppressed context, or pos

143 tential therapeutic approaches to reactivate latent infections in quiescent cells.

144 e in vivo, and quiescence is correlated with latent infections in T cells.

145 s characteristic of reactivation of lifelong latent infections.

146 that may play roles in regulating lytic and latent infections.

147 RIN1-knockout animals have deficits in latent inhibition and fear extinction in the amygdala, s

148 y, amphetamine sensitization was reduced and latent inhibition potentiated.

149 due to the reactivation of T cells harboring latent integrated provirus, and recent studies indicate

150 itive performance of fish was tested using a latent learning paradigm in a complex maze.

151 Se/g) exhibited impaired performance in the latent learning task.

152 (HCMV) is a herpesvirus with both lytic and latent life cycles.

153 nt viruses that establish a nonreactivating, latent-like or a replicative infection in CD34(+) hemato

154 In this study, we propose a latent low-rank (LLR) approach to colocalizing genetic r

155 ressed later, that distinguish subjects with latent (LTBI), pulmonary (PTB) or extrapulmonary (EPTB)

156 RON-TB Gold-Plus (QFT-Plus) for diagnosis of latent M. tuberculosis infection (LTBI).

157 uberculosis incidence in persons treated for latent MDR -TB infection is unknown.

158 express a transgene containing an engineered latent membrane protein 1 (LMP)/CD40 fusion protein conf

159 ts of EBNA2 (which hijacks Notch signaling), latent membrane protein 1 (LMP1) (which mimics CD40 sign

160 The EBV oncoprotein latent membrane protein 1 (LMP1) functions to constituti

161 Latent membrane protein 1 (LMP1) is an Epstein-Barr viru

162 EBV latent membrane protein 1 (LMP1) is required for the eff

163 ovide evidence that Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) promotes IRF4 phosphory

164 During latent infection, EBV encodes latent membrane protein 2A (LMP2A) to promote the surviv

165 decomposition of complex DNA methylomes into latent methylation components and their proportions in e

166 It accurately recovers cell-type-specific latent methylation components and their proportions.

167 nd portal of fetal transmission with risk of latent microcephaly and malformations.

168 actual saccade, indicating the presence of a latent movement command.

169 recognized by T cells from individuals with latent Mtb infection differs as a function of previous d

170 nia virus infection, and during a persistent/latent murine CMV infection.

171 mation of unobserved incorporation times and latent neural tunings.

172 Using immunofluorescence labeling of latent nuclear antigen (LANA) protein, together with flu

173 in 22 (31.0%), manifest latent nystagmus or latent nystagmus in 17 (24.0%), and 2 (2.8%) each associ

174 ital motor nystagmus in 22 (31.0%), manifest latent nystagmus or latent nystagmus in 17 (24.0%), and

175 The method maps multivariate data points to latent one-dimensional coordinates along their underlyin

176 Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-

177 , either HIV-infected or uninfected and with latent or active TB (aTB), were screened using M.tubercu

178 igh-titre (rapid plasma reagin titre >/=1:8) latent or active yaws, between April, 2013, and May, 201

179 Persistent (latent or actively replicating) JCV infection mostly pre

180 reviously established in the UK and remained latent or unnoticed as oilseed rape pathogen until recen

181 rucial role in the timing of reactivation of latent parasites towards proliferative stages.

182 CD8(+) T cell program normally reserved for latent pathogens and persistence in an immune-privileged

183 phyrin precursor excretors, and asymptomatic latent patients without symptoms or porphyrin precursor

184 We sought to explore latent patterns of sensitization during the first 6 year

185 lid-phase linker for the facile synthesis of latent peptide alpha-thioesters.

186 A Markov model with a latent period of 20 years and a time horizon of 50 years

187 includes the unobserved infection times and latent periods and quantifies them along with all other

188 S, this study: (i) examined the existence of latent personality profiles, (ii) studied their gender i

189 ring an adaptive cognitive state, can unmask latent plastic potential that durably improves resistant

190 on and demonstrate the potential to activate latent plasticity as a novel therapeutic strategy to res

191 inate to disassemble active holoenzymes into latent PP2A, strictly controlled by methylation.

192 During the latent pre-seizure period, epileptiform spikes were more

193 Latent profile analysis categorizes individuals with sim

194 Latent Profile Analysis in 2 samples (Canadian, longitud

195 Latent profile analysis supported a three-group model; a

196 cy-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effec

197 tribution change when KSHV switches from its latent (quiescent) phase to the lytic, infectious state.

198 er acute injury and allow for exploration of latent regenerative programs with potential applications

199 In the latent regime, the adsorbed polymer chains rearrange to

200 rst regime are found to be the causes of the latent regime.

201 meter values, we find that the presence of a latent reservoir can severely delay evolutionary dynamic

202 A latent reservoir for HIV-1 in resting CD4(+) T lymphocyt

203 The latent reservoir for HIV-1 in resting memory CD4(+) T ce

204 In conclusion, we argue that the latent reservoir has important, and hitherto under-appre

205 in acute HIV infection, measurements of the latent reservoir in chronic infection, and the replaceme

206 ly published clinical observations including latent reservoir size and the relationships to viral loa

207 Mathematical modeling predicted that the latent reservoir size was approximately 200 cells prior

208 t pharmacologic approaches to reactivate the latent reservoir so that infected cells can be recognize

209 -type virus by CTL escape mutants within the latent reservoir.

210 s elusive due to the persistence of HIV in a latent reservoir.

211 nal antibodies and assist in eliminating the latent reservoir.

212 Previous clinical attempts to reactivate the latent reservoirs in an individual so that they can be e

213 g of viral reservoirs, including reactivated latent reservoirs in clinical samples.

214 ter initial infection, the virus establishes latent reservoirs in sensory neurons and persists for li

215 e decades of therapy due to the existence of latent reservoirs of integrated HIV-1, which can reactiv

216 Children with latent RHD and >/=1 year of follow-up were included.

217 udinal outcomes of a cohort of children with latent RHD and identify risk factors for unfavorable out

218 Children with moderate to severe latent RHD have poor outcomes.

219 Latent RHD is a heterogeneous diagnosis with variable di

220 tcome remains unclear, the initial change in latent RHD may be evident during the first 1 to 2 years

221 penicillin prophylaxis on the trajectory of latent RHD.

222 tive cascade employing benzoyl fluoride as a latent source of fluoride is reported for signal amplifi

223 rum's-acid-based conjugate acceptor (1) as a latent source of thiol for signal amplification, as well

224 or for local trends, with the inclusion of a latent spring weather covariate.

225 t cells harboring the cysts to eliminate the latent stage of the parasite using mice with the H-2(d)

226 es Toxoplasma gondii and Plasmodium spp. use latent stages to persist in the host, facilitate transmi

227 sis (Mtb) can persist in the human host in a latent state for decades, in part because it has the abi

228 Our approach is unique within the class of latent state space models of neural activity in that it

229 uence fidelity during reactivations from its latent state within an individual host.

230 HIV life cycle, or its reactivation from the latent state, thus facilitating the development of antiv

231 enome during repeated reactivations from its latent state.

232 reinforcement-learning mechanism that infers latent statistical structure in dynamic task environment

233 Because LOST incorporates a latent stochastic auto-regressive term, LOST is able to

234 Orthogonal projection to latent structures by partial least square analysis was p

235 Orthogonal projections to latent structures-discriminant analysis (OPLS-DA) was ap

236 The reline solvent plays the role of a latent supramolecular catalyst where the increase in rea

237 l functional component of T-cell immunity in latent TB and potential correlate of protection.

238 owever, although HIV-uninfected persons with latent TB infection exhibited ex vivo M. tuberculosis-sp

239 with healthy HIV-uninfected individuals with latent TB infection.

240 thout cancer and would benefit from targeted latent TB screening and therapy.

241 atively resistant individuals diagnosed with latent TB, and from susceptible individuals that had rec

242 and outputs active TF-gene links as well as latent TF activities.

243 Release of latent TGF-beta or BMPs from dentine is not required for

244 the mature cytokine dimer from the inactive, latent TGF-beta precursor.

245 how that alphaV and beta8 interact with GARP/latent TGF-beta1 complexes in human Tregs.

246 s produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA

247 on between the integrin alphaVbeta8 and GARP/latent TGF-beta1 complexes.

248 mune cell types use surface GARP to activate latent TGF-beta1 was not known.

249 s base-triggered switching of behavior from "latent" to "active" nucleophile is a unique feature of b

250 Typically, a latent trajectory corresponding to a biological process

251 h the down-regulation of thrombospondin 1, a latent transforming growth factor-beta receptor, and tra

252 nase-2 (Mmp2) and Mmp9, which could activate latent transforming growth factor-beta1 (TGF-beta1).

253 Latent transition analyses identified unobserved risk pa

254 h which to assess and control bias in future latent transition analyses of clinical data.

255 A latent transition analysis model was used to categorize

256 Wilkinson et al. describe how they applied a latent transition analysis technique to surveillance dat

257 Latent transition models are beneficial for understandin

258 trialed the application of latent class and latent transition models to HIV surveillance data.

259 from uropathogenic Escherichia coli 536 is a latent tRNase that is only active when bound to the cyst

260 o assess validity coefficients (VCs) between latent "true" dietary estimates, total urinary polypheno

261 dations for treating persons having presumed latent tuberculosis (LTBI) after contact to infectious m

262 led trials have demonstrated that the newest latent tuberculosis (LTBI) regimen, 12 weekly doses of d

263 Renal transplant candidates (RTC) with latent tuberculosis infection (LTBI) are at significant

264 The tests for diagnosing latent tuberculosis infection (LTBI) are limited by a po

265 ence of the association between diabetes and latent tuberculosis infection (LTBI) remains limited and

266 HCW acceptance and compliance with available latent tuberculosis infection (LTBI) treatment regimens

267 or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]).

268 elling underline the necessity of addressing latent tuberculosis infection if further progress is to

269 r progress, scale-up of targeted testing for latent tuberculosis infection in at-risk populations, sc

270 indicate reactivation risk, and even shorter latent tuberculosis infection treatment regimens than cu

271 itis B, and 133 [51%] of 263 individuals for latent tuberculosis infection), mental health (eg, highe

272 recommendations about diagnostic testing for latent tuberculosis infection, pulmonary tuberculosis, a

273 duced T-cell responses and susceptibility to latent tuberculosis infection.

274 associated with increased susceptibility to latent tuberculosis infection.

275 on is thought to be involved in establishing latent tuberculosis infections in response to hypoxia an

276 Expanding latent tuberculosis treatment is important to decrease a

277 We apply a latent variable approach, exploratory bifactor analysis,

278 adjustment for demographics, risk factors, a latent variable for glycemia (diabetes status, fasting g

279 After additionally adjusting for the latent variable for glycemia, low 1,5-AG levels (<6.0 mu

280 A1c), fructosamine, glycated albumin), and a latent variable for kidney function (creatinine, cystati

281 lus features for estimating a user-specified latent variable from those stimuli.

282 is for accumulated evidence estimated from a latent variable model.

283 e sampling-based inference algorithm using a latent variable representation of the Poisson distributi

284 ral stimulus variability, the prior over the latent variable, noise power, and the choice of cost fun

285 discrete groups represented by a categorical latent variable.

286 Using a data-driven latent-variable approach, we demonstrate that a nested f

287 cient estimation through the introduction of latent variables and the appropriate application of rece

288 simulated DNA methylation data with a set of latent variables representing "cell types".

289 o and inadequate methods for quantifying the latent viral reservoir in individuals receiving antiretr

290 response and blocking the establishment of a latent viral reservoir in the guinea pig challenge model

291 eutics target lytic replication, but not the latent viral reservoir; thus, an understanding of the mo

292 eradication of HIV/AIDS is the existence of latent viral reservoirs.

293 with the brain forming a sanctuary site for latent virus and low-level viral replication in the abse

294 ponse and reduce the rate of reactivation of latent virus infection.

295 ion with mouse cytomegalovirus, a persistent-latent virus that elicits different cytotoxic T cell res

296 Periodically, latent virus undergoes reactivation whereby lytic genes

297 specific assays to quantitate reactivatable latent virus.

298 d genes that are differentially regulated in latent vs. replicative states of infection.

299 was achieved in 151 (92%) participants with latent yaws and 101 (94%) with active yaws (risk differe

300 Treatment of latent yaws was taken to be non-inferior to that of acti