ライフサイエンスコーパス: lateral inhibition

1 cells becoming photoreceptors - a process of lateral inhibition).

2 These can be larger than those formed with lateral inhibition.

3 netics and spatial dependence to account for lateral inhibition.

4 h signaling, which limits MCC fate choice by lateral inhibition.

5 , thereby directly bearing on the process of lateral inhibition.

6 r within a simple cellular automata model of lateral inhibition.

7 wn microcircuit motifs: pyramidal cells with lateral inhibition.

8 rrect specification of cell fates induced by lateral inhibition.

9 T distribution as an emergent consequence of lateral inhibition.

10 mitotic, and unresponsive to Notch-dependent lateral inhibition.

11 hat some progenitor cells are insensitive to lateral inhibition.

12 pikes in L1 interneurons, followed by strong lateral inhibition.

13 therefore be included in standard models of lateral inhibition.

14 se to Wingless through at least two modes of lateral inhibition.

15 iously published data from other examples of lateral inhibition.

16 ten relies on spatial filters implemented by lateral inhibition.

17 ies that have previously appeared to require lateral inhibition.

18 predicted by the model for plants that lack lateral inhibition.

19 have failed to find consistent evidence for lateral inhibition.

20 tion with delta-like 4 (Dll4)/notch-mediated lateral inhibition.

21 t to depend on the presence of intracortical lateral inhibition.

22 roblast fate via failure of Delta1-dependent lateral inhibition.

23 isted of focused facilitation and widespread lateral inhibition.

24 vern this pattern of differentiation through lateral inhibition.

25 ursor/epidermal cell fate distinction during lateral inhibition.

26 This restriction involves Notch-mediated lateral inhibition.

27 receptive fields through mechanisms such as lateral inhibition.

28 roposed to control the heterocyst pattern by lateral inhibition.

29 from the previously recognized mechanism of lateral inhibition.

30 tion, however, did not affect the outcome of lateral inhibition.

31 M/T cell spikes, and the timing of M/T cell lateral inhibition.

32 s not due to the lack of Notch (N)-dependent lateral inhibition.

33 thway that is usually assumed simply to give lateral inhibition.

34 ional properties different from conventional lateral inhibition.

35 restricting neural-fate specification during lateral inhibition.

36 ppression of recurrent excitation underlying lateral inhibition.

37 ntrast between related chemicals by means of lateral inhibition.

38 jections act via mechanisms such as surround/lateral inhibition.

39 to discrete rows mediated by Notch-dependent lateral inhibition.

40 id not increase the strength of M72-mediated lateral inhibition.

41 eam olfactory networks and those filtered by lateral inhibition.

42 d leader cells are regulated via Notch1-Dll4 lateral inhibition.

43 in their sister cells through Notch-mediated lateral inhibition.

44 activity, and the effects of respiration on lateral inhibition, a major component of sensory process

45 this signalling pathway is that of mediating lateral inhibition, a process where exchange of signals

46 Lateral inhibition, a symmetrical cell-cell competition

47 esicular release constraint realized through lateral inhibition across presynaptic membrane, (2) the

48 cells and thereby bias the outcome of mutual lateral inhibition acting between H and N cells.

49 tory responses of granule cells and M/T cell lateral inhibition adapt quickly after the first respira

50 lexible categorization cannot be achieved by lateral inhibition alone but also requires that the inhi

51 However, lateral inhibition alone is insufficient to produce mosa

52 Weakened lateral inhibition also produces an increased sensitivit

53 gulated, at least in part, by NOTCH-mediated lateral inhibition among crest-derived cells, and by asy

54 nsemble activity more sparse by facilitating lateral inhibition among MTs and/or enforce temporally p

55 /stalk patterning, highlighting filopodia as lateral inhibition amplifiers.

56 hat is required for Notch signaling-mediated lateral inhibition and cell fate determination of extern

57 niently implemented in software, whereas the lateral inhibition and classification stages run on acce

58 these findings reveal that SOM cells govern lateral inhibition and control cortical frequency tuning

59 Their output is processed by lateral inhibition and drives a winner-take-all circuit

60 critical to their function, as it underpins lateral inhibition and effective translation of stimuli

61 hotoreceptors and horizontal cells underlies lateral inhibition and establishes the antagonistic cent

62 gs provide insight into the circuit basis of lateral inhibition and functional interactions within an

63 for pattern recognition tasks in presence of lateral inhibition and homeostasis.

64 iMSNs impaired cocaine's ability to suppress lateral inhibition and increase locomotion.

65 Ero1L mutant clones show specific defects in lateral inhibition and inductive signaling, two characte

66 Thus, lateral inhibition and intestinal crypt lineage plastici

67 The functional relevance of this lateral inhibition and its regulation by dopamine remain

68 ta-Notch dynamics determine the influence of lateral inhibition and lateral induction on the selectio

69 ent work on signaling cascades, particularly lateral inhibition and planar cell polarity, has begun t

70 tterning in the cochlea, acting both through lateral inhibition and the control of cellular prolifera

71 maintains the sensitivity of progenitors to lateral inhibition and thus limits further proneural upr

72 opmental processes - cell-fate induction and lateral inhibition - and ask whether the landscapes for

73 nitor cell population through Notch-mediated lateral inhibition, and Math1 irreversibly commits these

74 plement synapse-specific, activity-dependent lateral inhibition, and thus could provide an efficient

75 ssed exclusively in HCs, are consistent with lateral inhibition as the trigger for alkalinization.

76 to test for the presence of interglomerular lateral inhibition, as well as its underlying mechanisms

77 omerular layer, although evidence supporting lateral inhibition at a functional level is modest.

78 Lateral inhibition at the first synapse in the retina is

79 irst, we showed how the effect of well known lateral inhibition at the outer retina, mediated by hori

80 ses from reiterative organogenesis driven by lateral inhibitions at the shoot apex.

81 The bias could be explained by a model of lateral inhibition based on the overrepresentation of fr

82 This raises the question of whether lateral inhibition between glomeruli is specific or nons

83 (SACs) comprise the first network mediating lateral inhibition between glomeruli, the functional uni

84 on and inhibition in the STN-GP network, and lateral inhibition between GP neurons, could actively su

85 We find differences in activity-dependent lateral inhibition between mitral and tufted cells that

86 Granule cells mediate interglomerular lateral inhibition between mitral and tufted cells' late

87 shed light on the functional significance of lateral inhibition between MSNs and offer a novel synapt

88 pairs of striatal neurons revealed that only lateral inhibition between MSNs is negatively modulated,

89 Lateral inhibition between near-neighbor neurons has lon

90 Simultaneously, short-range lateral inhibition between neighboring cells produce com

91 er-surround receptive fields, a prototype of lateral inhibition between neighboring sensory cells in

92 Lateral inhibition between neurons occurs in many differ

93 ctional properties of the circuits mediating lateral inhibition between olfactory bulb principal neur

94 ternative to commonly proposed mechanisms of lateral inhibition between OR-specific glomeruli.

95 electrical ("ephaptic") interactions mediate lateral inhibition between ORNs.

96 Lateral inhibition between pairs of olfactory bulb (OB)

97 participate in a fast-onset intraglomerular lateral inhibition between principal neurons from the sa

98 rspective is on the underappreciated role of lateral inhibition between striatal projection cells in

99 lomerular (PG) cells mediate intraglomerular lateral inhibition between their apical dendrites.

100 Lateral inhibition between these 2 glomeruli reflects th

101 However, they also receive unusually strong lateral inhibition, both pre- and postsynaptically, trig

102 Here, we provide new evidence that lateral inhibition, but not ro, is required for the init

103 ner ear is regulated by Notch signalling and lateral inhibition, but the dynamics of this process and

104 ximal pathway likely enables GCs to regulate lateral inhibition by defining time windows when lateral

105 R8 precursor cells are protected from lateral inhibition by Delta.

106 tic data indicate that MpFRH1 miRNA mediates lateral inhibition by repressing MpRSL1 during pattern f

107 is known to be influenced (via CPC-mediated lateral inhibition) by the non-hair cells.

108 e decisions, and that the standard model for lateral inhibition can account for a wider range of deve

109 operties of a standard mathematical model of lateral inhibition can lead to stable symmetric signalli

110 Lateral inhibition can subdivide an initially irregular

111 We conclude that lateral inhibition can transform irregular distributions

112 Together these mechanisms, without lateral inhibition, can account for contrast-invariant s

113 We demonstrate that classical feedforward lateral inhibition cannot produce flexible categorizatio

114 Simulations show that this regulation of lateral inhibition causes decorrelation of mitral cell a

115 signaling events reveal a robust pattern of lateral inhibition conducted by Ato-coordinated Notch an

116 Because lateral inhibition confers both costs and benefits, the

117 Lateral inhibition depends on LET-99, which inhibits GPR

118 ites, the likely purveyors of Notch-mediated lateral inhibition, do not support a role for these site

119 Mechanistically, such lateral inhibition does not depend on synapses and is pr

120 nstrate an important role for Notch-mediated lateral inhibition during cochlear hair cell patterning,

121 the generally assumed mode of operation for lateral inhibition during development; more generally, t

122 Notch and Delta are required for lateral inhibition during eye development.

123 ) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as

124 d that neu is required cell-autonomously for lateral inhibition during peripheral neurogenesis and fo

125 le for other N-mediated processes, including lateral inhibition during wing vein development and wing

126 lation between MSNs attributable to weakened lateral inhibition enables the strong influence of synch

127 upport a new model for R8 selection in which lateral inhibition establishes a transient pattern of se

128 bles additional spectral comparisons through lateral inhibition, expanding the range of chromatic enc

129 the root epidermis, which generates a second lateral inhibition feedback loop.

130 Dopamine D2 receptors (D2Rs) suppress lateral inhibition from iMSNs to disinhibit dMSNs, which

131 ells of the model receive strong (nonlinear) lateral inhibition from other neurons in the model corte

132 inhibition of NAc MSNs from CB1(+) FSIs and lateral inhibition from recurrent MSN collaterals.

133 Thus, spatially offset lateral inhibition generates directionality at three dif

134 p early and in excess, in agreement with the lateral inhibition hypothesis.

135 ssible resolution of a debate on the role of lateral inhibition in cell fate specification.

136 otch-dependent cell fate decisions including lateral inhibition in Drosophila neurogenesis.

137 Notch signalling is well-known to mediate lateral inhibition in inner ear sensory patches, so as t

138 jacent ORN, suggesting a broad occurrence of lateral inhibition in insects and possible applications

139 e diverse response patterns reported in vivo-lateral inhibition in some cases, approximately balanced

140 ractions suggest that interneurons mediating lateral inhibition in the central retina, likely horizon

141 nization in the time domain is due to strong lateral inhibition in the highly specialized area of the

142 Neuron, Fantana et al. provide evidence that lateral inhibition in the olfactory bulb selectively act

143 sents a candidate mechanism for subthreshold lateral inhibition in the olfactory bulb.

144 gests novel mechanisms for the regulation of lateral inhibition in the olfactory bulb.

145 Moreover, lateral inhibition in the periphery can modulate olfacto

146 e signal, a fixed feature in the signal, and lateral inhibition in the receiver.

147 e-enhancement phenomena produced by means of lateral inhibition in the retina of the eye.

148 These findings reveal that protons mediate lateral inhibition in the retina, raising the possibilit

149 tion to delineating processes that establish lateral inhibition in the retina, these results contribu

150 r terminals and thus provide a substrate for lateral inhibition in the rod pathway.

151 Lateral inhibition in the vertebrate retina depends on a

152 Here, however, we present an example of lateral inhibition in which unidirectional signaling dep

153 Reduced lateral inhibition in zebrafish mib mutant embryos permi

154 ptional regulator TAZ as a novel mediator of lateral inhibition in zebrafish oogenesis that directs c

155 , many response properties appear to require lateral inhibition, including precise orientation and di

156 quantitatively reproduced by simulations of lateral inhibition incorporating Delta-Notch signaling b

157 Lateral inhibition increases the level of feedforward in

158 Given the role of M/TCs in OB output and in lateral inhibition, increasing the number of M/TCs conne

159 Lateral inhibition, inhibitory postsynaptic potentials e

160 1(lof) mutants indicate that MpFRH1-mediated lateral inhibition involves the repression of MpRSL1 act

161 Lateral inhibition is a circuit motif found throughout t

162 Lateral inhibition is a common feature of cortical netwo

163 Lateral inhibition is a fundamental circuit operation th

164 Lateral inhibition is a fundamental feature of circuits

165 f particular odorants.SIGNIFICANCE STATEMENT Lateral inhibition is a key feature of circuitry in many

166 Lateral inhibition is a pervasive process in which one c

167 acute OB slices from mice, we tested whether lateral inhibition is affected by prior odor exposure an

168 two mechanisms: 1) Where there are hotspots, lateral inhibition is amplified; 2) Where no hotspots em

169 n individual sensilla, we find that ephaptic lateral inhibition is asymmetric such that one ORN exert

170 ral inhibition by defining time windows when lateral inhibition is functional.SIGNIFICANCE STATEMENT

171 f cone inputs to the circuitry that mediates lateral inhibition is not cone-type specific, but whethe

172 Lateral inhibition is one of the key functions of Notch

173 naptic activity is required before effective lateral inhibition is recruited.

174 ctor, is sequestered apically at a time when lateral inhibition is required for patterning in the dev

175 A second model proposes that lateral inhibition is sufficient to select a single R8 f

176 Notch-mediated lateral inhibition is the proposed mechanism for creatin

177 f auditory processing in which broadly tuned lateral inhibition is used to limit excitatory receptive

178 positive feedback associated with widespread lateral inhibition, is mediated by the cortical neural n

179 tation--reciprocal inhibition of feedforward lateral inhibition--is structurally the simplest, and it

180 nt downstream mediators of Notch function in lateral inhibition, it is not known what genes function

181 ty represents the process by which effective lateral inhibition leads to diversification of progenito

182 te line communication.SIGNIFICANCE STATEMENT Lateral inhibition (LI) is a fundamental feature of info

183 Lateral inhibition may be a general mechanism behind the

184 In the olfactory bulb, lateral inhibition may occur between odorant receptor-sp

185 Intraglomerular lateral inhibition may play a key role in olfactory proc

186 dels, e.g., adapting neural populations with lateral inhibition, may account for the dynamics of bist

187 t of a self-forming pattern, emerging from a lateral inhibition mechanism determined by a network of

188 fashion in the pronephros, suggesting that a lateral inhibition mechanism may play a role in their di

189 then participates in a negative feedback and lateral inhibition mechanism that defines the precise pa

190 The truncated MYB encoded by CPC mediates a lateral inhibition mechanism to negatively regulate WER,

191 ly, the interaction along scale implements a lateral inhibition mechanism, a canonical principle that

192 rol endocrine cell differentiation through a lateral inhibition mechanism; and that alpha and beta ce

193 imary or secondary fate using one of several lateral inhibition mechanisms.

194 otrusions that deliver temporally controlled lateral inhibition mediated at a distance.

195 potential to become sensory hair cells, and lateral inhibition mediated by Delta-Notch signaling res

196 ault in the absence of Notch activation, and lateral inhibition mediated by Delta-Notch signalling is

197 Lateral inhibition mediated by Delta/Notch (Dl/N) signal

198 in different networks engage in long-lasting lateral inhibition mediated by dendrodendritic synapses

199 ductive cellular determination signal, while lateral inhibition mediated by Notch antagonizes this ac

200 Lateral inhibition mediated by Notch is thought to gener

201 ion of this complex cellular mosaic requires lateral inhibition mediated by Notch signaling.

202 toreceptor interactions were consistent with lateral inhibition mediated by retinal horizontal cells

203 ted from proneural clusters via a process of lateral inhibition mediated by the Notch signaling pathw

204 ay serve to modulate, over a long timescale, lateral inhibition mediated by these cells.

205 Mathematical modeling predicts that lateral inhibition, mediated by Notch signaling, functio

206 Lateral inhibition, mediated by Notch signaling, leads t

207 Second, lateral inhibition, mediated by the neurogenic genes, ac

208 have used computer modelling to test whether lateral inhibition might transform an initial population

209 In support of the standard lateral inhibition model, both continuous and Hes5-regul

210 Unlike a standard lateral inhibition model, our picture implies that R8s a

211 in contrast to the predictions of classical lateral inhibition models.

212 nderlying the regulation of neurogenesis and lateral inhibition of boundary cell formation by Wnt1 ha

213 on selectivity, and we show that it includes lateral inhibition of glutamatergic bipolar cells and se

214 ng MSX2 expression, which, in turn, leads to lateral inhibition of hair follicle formation within the

215 other photoreceptor fates and is involved in lateral inhibition of interommatidial bristles but is no

216 back loop between Notch and Delta leading to lateral inhibition of neighboring cells.

217 One early-acting mechanism is the lateral inhibition of neighbouring cells from acquiring

218 ections between glomeruli mediated only weak lateral inhibition of OSN inputs in slices and did not d

219 ty between projection neurons, feedback, and lateral inhibition of these axons by a large population

220 Differential effects of lateral inhibition onto MCs and TCs via distinct lateral

221 We found that lateral inhibition onto Off SACs from non-SAC amacrine c

222 In contrast, lateral inhibition onto On SACs is not necessary for dir

223 actory neural circuitry shows that decreased lateral inhibition onto projection neurons relaying sens

224 rons, increases the strength of M72-mediated lateral inhibition onto TCs, but not MCs, that project t

225 ne increased the strength of interglomerular lateral inhibition onto TCs, but not MCs, when the M72 g

226 istent with a theoretical model where either lateral inhibition or co-tuning can predominate, dependi

227 gh level of Neurog3 expression could mediate lateral inhibition or other unknown feedback mechanisms

228 prisingly, while misexpression of m6 impairs lateral inhibition, overexpression of m2 potentiates it,

229 Lateral inhibition patterns differentiated cell types am

230 itates the formation of sharp boundaries and lateral-inhibition patterns in models of development, an

231 both the early prosensory phase and a later lateral inhibition phase.

232 is sufficient to rescue neur function in the lateral inhibition process by which adult sensory organ

233 dence that Barbu can antagonize Notch during lateral inhibition processes in the embryonic mesoderm,

234 s cellular differentiation in Notch-mediated lateral inhibition processes, such that smaller cells ar

235 hancement of glycinergic IPSPs and transient lateral inhibition produced by a rotating windmill patte

236 al approaches, we show that Notch1a-mediated lateral inhibition produces a bistable switch that relia

237 Lateral inhibition produces the centre-surround organiza

238 rovided pure inhibition, consistent with the lateral inhibition proposed earlier.

239 romatin in equipotent progenitors undergoing lateral inhibition quickly enables distinct, transiently

240 We found that the lateral inhibition received by mitral cells is gated by

241 nd circuit modeling indicate that asymmetric lateral inhibition reflects a surprisingly simple mechan

242 We propose that Notch mediated lateral inhibition regulates the relative numbers of spe

243 anisms underlying this underexplored form of lateral inhibition remain unclear.

244 ontal cells to photoreceptors that generates lateral inhibition remains uncertain.

245 Lateral inhibition requires the Notch intracellular doma

246 Later, lateral inhibition restores the repression of neural dev

247 enesis, Notch ligands from nascent HCs exert lateral inhibition, restricting HC production.

248 h signalling within each such patch mediates lateral inhibition, restricting the proportion of cells

249 for many developmental processes, including lateral inhibition, segmentation, sex determination, dor

250 the olfactory bulb in vitro and measured how lateral inhibition shapes correlations across timescales

251 on Ca(2+) imaging in awake mice to show that lateral inhibition shapes frequency tuning in primary au

252 ry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate.

253 cortical properties of localized processing, lateral inhibition, simultaneous contrast, and nonlinear

254 Without lateral inhibition, some cells acquire ectopic fates.

255 However, how this lateral inhibition system works at the molecular level i

256 erved for patterns with cellular homogeneity-lateral inhibition tends to give short-range patterns, w

257 imprecise rebound bursting; (2) TRN-mediated lateral inhibition that further desynchronizes firing in

258 ompetition appears to involve Notch-mediated lateral inhibition that prevents extra cells from assumi

259 ef, early exposure to light to stabilize the lateral inhibition that shapes receptive fields.

260 The role of the Notch pathway during the lateral inhibition that underlies binary cell fate choic

261 of excitatory and inhibitory neurons induces lateral inhibition that, through the timing and strength

262 As in lateral inhibition, the metalloprotease Kuzbanian, the E

263 tory-specific transcription factor, controls lateral inhibition through delta-like notch ligand genes

264 e speculate that mGluRs amplify spike-driven lateral inhibition through the mitral-to-granule cell ci

265 me have long been proposed in the context of lateral inhibition through the Notch-Delta pathway, some

266 tine crypts, where notch signalling mediates lateral inhibition to assign progenitor cells into absor

267 is dynamic regulation allows the strength of lateral inhibition to be enhanced between cells with cor

268 additional mechanisms operate downstream of lateral inhibition to eliminate patterning errors in the

269 tributions of these two forms of presynaptic lateral inhibition to ganglion cell light sensitivity by

270 hese events act together with the process of lateral inhibition to generate precursor cells (neurobla

271 previous models require local excitation and lateral inhibition to maintain spatially localized persi

272 Feedback models rely on lateral inhibition to refine selectivity relative to a w

273 theoretical explanations ranging from simple lateral inhibition to those based on the influence of kn

274 The model predicted that in the absence of lateral inhibition, two-dimensional rhizoid cell groups

275 tationary edges on any surrounds, ruling out lateral inhibition-type explanations.

276 Proneural enhancement and lateral inhibition use similar ligand binding and recept

277 However, circuits in which the strength of lateral inhibition varies with the relative strength of

278 Cell fate determination by lateral inhibition via Notch/Delta signalling has been e

279 ing behavior emerges from the interaction of lateral inhibition (via the surround pathways), which is

280 thermore, the network suppression underlying lateral inhibition was blocked by inactivation of somato

281 The observed lateral inhibition was entirely dependent on circuitry w

282 However, lateral inhibition was not uniformly larger during a par

283 binoid (eCB) signaling, whereas MSN-mediated lateral inhibition was unaffected.

284 In the absence of nasal airflow, lateral inhibition was weaker in mitral cells and less m

285 as been thought to arise from an increase in lateral inhibition, we find that the inhibition that cel

286 To test if MpFRH1 miRNA acts during lateral inhibition, we generated loss-of-function (lof)

287 ication has been well studied in the case of lateral inhibition, where ligand binding at the cell sur

288 bipotential progenitors is then governed by lateral inhibition, where Notch>Hes1-mediated Ngn3 prote

289 rk for an updated model of the intrastriatal lateral inhibition, where we explore its contribution to

290 some theories invoke enhancement of edges by lateral inhibition, whereas others rely on transients ca

291 Lateral inhibition, wherein a single cell signals to its

292 to cone signals is horizontal-cell-mediated lateral inhibition, which imparts a spatially antagonist

293 particular circuit element, interglomerular lateral inhibition, which is known to be critical for a

294 pared the effects of blocking just the known lateral inhibition with blocking all GABAergic inhibitio

295 near summation of non-patterned stimuli, and lateral inhibition with spatial patterns [5], which incr

296 n of a repressive patterning signal, such as lateral inhibition, with continued developmental plastic

297 k connections between areas, and short-range lateral inhibition within each area.

298 conductance-based model that only contained lateral inhibition within L1 recapitulated the sensory r

299 This induces lateral inhibition, yielding a pattern in which each Del

300 We show that lateral inhibition yields robustness to changes in prepa