ライフサイエンスコーパス: lateral inhibition

1 cells becoming photoreceptors - a process of lateral inhibition).

2 eractions between adjacent progenitor cells (lateral inhibition).

3 hat some progenitor cells are insensitive to lateral inhibition.

4 therefore be included in standard models of lateral inhibition.

5 se to Wingless through at least two modes of lateral inhibition.

6 iously published data from other examples of lateral inhibition.

7 ten relies on spatial filters implemented by lateral inhibition.

8 ies that have previously appeared to require lateral inhibition.

9 have failed to find consistent evidence for lateral inhibition.

10 tion with delta-like 4 (Dll4)/notch-mediated lateral inhibition.

11 t to depend on the presence of intracortical lateral inhibition.

12 roblast fate via failure of Delta1-dependent lateral inhibition.

13 isted of focused facilitation and widespread lateral inhibition.

14 vern this pattern of differentiation through lateral inhibition.

15 ursor/epidermal cell fate distinction during lateral inhibition.

16 This restriction involves Notch-mediated lateral inhibition.

17 receptive fields through mechanisms such as lateral inhibition.

18 roposed to control the heterocyst pattern by lateral inhibition.

19 from the previously recognized mechanism of lateral inhibition.

20 tion, however, did not affect the outcome of lateral inhibition.

21 M/T cell spikes, and the timing of M/T cell lateral inhibition.

22 s not due to the lack of Notch (N)-dependent lateral inhibition.

23 thway that is usually assumed simply to give lateral inhibition.

24 ional properties different from conventional lateral inhibition.

25 restricting neural-fate specification during lateral inhibition.

26 ntrast between related chemicals by means of lateral inhibition.

27 ignalling, which is unrelated to its role in lateral inhibition.

28 required for normal levels of Delta-mediated lateral inhibition.

29 appropriate axon projections for generating lateral inhibition.

30 stimulated cell, which may be indicative of lateral inhibition.

31 iation in their immediate neighbours through lateral inhibition.

32 to discrete rows mediated by Notch-dependent lateral inhibition.

33 id not increase the strength of M72-mediated lateral inhibition.

34 eam olfactory networks and those filtered by lateral inhibition.

35 d leader cells are regulated via Notch1-Dll4 lateral inhibition.

36 in their sister cells through Notch-mediated lateral inhibition.

37 netics and spatial dependence to account for lateral inhibition.

38 h signaling, which limits MCC fate choice by lateral inhibition.

39 , thereby directly bearing on the process of lateral inhibition.

40 wn microcircuit motifs: pyramidal cells with lateral inhibition.

41 rrect specification of cell fates induced by lateral inhibition.

42 T distribution as an emergent consequence of lateral inhibition.

43 mitotic, and unresponsive to Notch-dependent lateral inhibition.

44 activity, and the effects of respiration on lateral inhibition, a major component of sensory process

45 uring embryonic development, particularly in lateral inhibition, a process that acts on groups of cel

46 this signalling pathway is that of mediating lateral inhibition, a process where exchange of signals

47 Lateral inhibition, a symmetrical cell-cell competition

48 esicular release constraint realized through lateral inhibition across presynaptic membrane, (2) the

49 cells and thereby bias the outcome of mutual lateral inhibition acting between H and N cells.

50 tory responses of granule cells and M/T cell lateral inhibition adapt quickly after the first respira

51 lexible categorization cannot be achieved by lateral inhibition alone but also requires that the inhi

52 However, lateral inhibition alone is insufficient to produce mosa

53 Weakened lateral inhibition also produces an increased sensitivit

54 gulated, at least in part, by NOTCH-mediated lateral inhibition among crest-derived cells, and by asy

55 nsemble activity more sparse by facilitating lateral inhibition among MTs and/or enforce temporally p

56 /stalk patterning, highlighting filopodia as lateral inhibition amplifiers.

57 hat is required for Notch signaling-mediated lateral inhibition and cell fate determination of extern

58 niently implemented in software, whereas the lateral inhibition and classification stages run on acce

59 these findings reveal that SOM cells govern lateral inhibition and control cortical frequency tuning

60 Their output is processed by lateral inhibition and drives a winner-take-all circuit

61 critical to their function, as it underpins lateral inhibition and effective translation of stimuli

62 hotoreceptors and horizontal cells underlies lateral inhibition and establishes the antagonistic cent

63 gs provide insight into the circuit basis of lateral inhibition and functional interactions within an

64 for pattern recognition tasks in presence of lateral inhibition and homeostasis.

65 iMSNs impaired cocaine's ability to suppress lateral inhibition and increase locomotion.

66 Ero1L mutant clones show specific defects in lateral inhibition and inductive signaling, two characte

67 Thus, lateral inhibition and intestinal crypt lineage plastici

68 The functional relevance of this lateral inhibition and its regulation by dopamine remain

69 ent work on signaling cascades, particularly lateral inhibition and planar cell polarity, has begun t

70 ired for specification of precursor cells by lateral inhibition and subsequently for differentiation

71 tterning in the cochlea, acting both through lateral inhibition and the control of cellular prolifera

72 maintains the sensitivity of progenitors to lateral inhibition and thus limits further proneural upr

73 opmental processes - cell-fate induction and lateral inhibition - and ask whether the landscapes for

74 promotes continuous SOP recruitment despite lateral inhibition, and it attenuates the effect of late

75 nitor cell population through Notch-mediated lateral inhibition, and Math1 irreversibly commits these

76 rounds in which both Wingless signalling and lateral inhibition are disrupted.

77 Finally, the concept of lateral inhibition, as usually understood and applied to

78 to test for the presence of interglomerular lateral inhibition, as well as its underlying mechanisms

79 omerular layer, although evidence supporting lateral inhibition at a functional level is modest.

80 These results illustrate how lateral inhibition at successive synaptic stages can sel

81 Lateral inhibition at the first synapse in the retina is

82 lls is widely believed to result mainly from lateral inhibition at the first synaptic level (in the o

83 irst, we showed how the effect of well known lateral inhibition at the outer retina, mediated by hori

84 Off-axis illumination elicits lateral inhibition at the primary visual synapse in crus

85 ses from reiterative organogenesis driven by lateral inhibitions at the shoot apex.

86 The bias could be explained by a model of lateral inhibition based on the overrepresentation of fr

87 This raises the question of whether lateral inhibition between glomeruli is specific or nons

88 on and inhibition in the STN-GP network, and lateral inhibition between GP neurons, could actively su

89 We find differences in activity-dependent lateral inhibition between mitral and tufted cells that

90 shed light on the functional significance of lateral inhibition between MSNs and offer a novel synapt

91 pairs of striatal neurons revealed that only lateral inhibition between MSNs is negatively modulated,

92 Lateral inhibition between near-neighbor neurons has lon

93 Simultaneously, short-range lateral inhibition between neighboring cells produce com

94 er-surround receptive fields, a prototype of lateral inhibition between neighboring sensory cells in

95 Lateral inhibition between neurons occurs in many differ

96 ctional properties of the circuits mediating lateral inhibition between olfactory bulb principal neur

97 ternative to commonly proposed mechanisms of lateral inhibition between OR-specific glomeruli.

98 Lateral inhibition between pairs of olfactory bulb (OB)

99 participate in a fast-onset intraglomerular lateral inhibition between principal neurons from the sa

100 Previously, it was shown that lateral inhibition between regions separated by 1 mm per

101 rspective is on the underappreciated role of lateral inhibition between striatal projection cells in

102 However, they also receive unusually strong lateral inhibition, both pre- and postsynaptically, trig

103 ells is not only regulated by Notch-mediated lateral inhibition, but is also an example where differe

104 Here, we provide new evidence that lateral inhibition, but not ro, is required for the init

105 ner ear is regulated by Notch signalling and lateral inhibition, but the dynamics of this process and

106 R8 precursor cells are protected from lateral inhibition by Delta.

107 is known to be influenced (via CPC-mediated lateral inhibition) by the non-hair cells.

108 e decisions, and that the standard model for lateral inhibition can account for a wider range of deve

109 operties of a standard mathematical model of lateral inhibition can lead to stable symmetric signalli

110 Lateral inhibition can subdivide an initially irregular

111 We conclude that lateral inhibition can transform irregular distributions

112 Together these mechanisms, without lateral inhibition, can account for contrast-invariant s

113 We demonstrate that classical feedforward lateral inhibition cannot produce flexible categorizatio

114 Simulations show that this regulation of lateral inhibition causes decorrelation of mitral cell a

115 signaling events reveal a robust pattern of lateral inhibition conducted by Ato-coordinated Notch an

116 Because lateral inhibition confers both costs and benefits, the

117 Lateral inhibition depends on LET-99, which inhibits GPR

118 ites, the likely purveyors of Notch-mediated lateral inhibition, do not support a role for these site

119 Mechanistically, such lateral inhibition does not depend on synapses and is pr

120 nstrate an important role for Notch-mediated lateral inhibition during cochlear hair cell patterning,

121 the generally assumed mode of operation for lateral inhibition during development; more generally, t

122 Notch and Delta are required for lateral inhibition during eye development.

123 ) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as

124 d that neu is required cell-autonomously for lateral inhibition during peripheral neurogenesis and fo

125 le for other N-mediated processes, including lateral inhibition during wing vein development and wing

126 lation between MSNs attributable to weakened lateral inhibition enables the strong influence of synch

127 upport a new model for R8 selection in which lateral inhibition establishes a transient pattern of se

128 the root epidermis, which generates a second lateral inhibition feedback loop.

129 Dopamine D2 receptors (D2Rs) suppress lateral inhibition from iMSNs to disinhibit dMSNs, which

130 ells of the model receive strong (nonlinear) lateral inhibition from other neurons in the model corte

131 inhibition of NAc MSNs from CB1(+) FSIs and lateral inhibition from recurrent MSN collaterals.

132 Thus, spatially offset lateral inhibition generates directionality at three dif

133 p early and in excess, in agreement with the lateral inhibition hypothesis.

134 s provide direct evidence for Notch-mediated lateral inhibition in a mammalian system and support a r

135 ssible resolution of a debate on the role of lateral inhibition in cell fate specification.

136 otch-dependent cell fate decisions including lateral inhibition in Drosophila neurogenesis.

137 Notch signalling is well-known to mediate lateral inhibition in inner ear sensory patches, so as t

138 jacent ORN, suggesting a broad occurrence of lateral inhibition in insects and possible applications

139 e diverse response patterns reported in vivo-lateral inhibition in some cases, approximately balanced

140 physical experiments led to Bekesy's idea of lateral inhibition in the auditory nervous system.

141 ractions suggest that interneurons mediating lateral inhibition in the central retina, likely horizon

142 matostatinergic neuron loss and suggest that lateral inhibition in the dentate gyrus does not require

143 nization in the time domain is due to strong lateral inhibition in the highly specialized area of the

144 Blocking lateral inhibition in the inner retina eliminates the pr

145 ertain on-center ganglion cells results from lateral inhibition in the inner retina, via GABAergic am

146 Neuron, Fantana et al. provide evidence that lateral inhibition in the olfactory bulb selectively act

147 sents a candidate mechanism for subthreshold lateral inhibition in the olfactory bulb.

148 gests novel mechanisms for the regulation of lateral inhibition in the olfactory bulb.

149 Moreover, lateral inhibition in the periphery can modulate olfacto

150 e signal, a fixed feature in the signal, and lateral inhibition in the receiver.

151 e-enhancement phenomena produced by means of lateral inhibition in the retina of the eye.

152 These findings reveal that protons mediate lateral inhibition in the retina, raising the possibilit

153 tion to delineating processes that establish lateral inhibition in the retina, these results contribu

154 r terminals and thus provide a substrate for lateral inhibition in the rod pathway.

155 Here, however, we present an example of lateral inhibition in which unidirectional signaling dep

156 Reduced lateral inhibition in zebrafish mib mutant embryos permi

157 , many response properties appear to require lateral inhibition, including precise orientation and di

158 quantitatively reproduced by simulations of lateral inhibition incorporating Delta-Notch signaling b

159 Lateral inhibition increases the level of feedforward in

160 Given the role of M/TCs in OB output and in lateral inhibition, increasing the number of M/TCs conne

161 ow that dendrodendritic synapses can mediate lateral inhibition independently of axonal action potent

162 Lateral inhibition, inhibitory postsynaptic potentials e

163 Lateral inhibition is a circuit motif found throughout t

164 Lateral inhibition is a common feature of cortical netwo

165 Lateral inhibition is a fundamental circuit operation th

166 Lateral inhibition is a pervasive process in which one c

167 acute OB slices from mice, we tested whether lateral inhibition is affected by prior odor exposure an

168 two mechanisms: 1) Where there are hotspots, lateral inhibition is amplified; 2) Where no hotspots em

169 The process of lateral inhibition is implemented by the nuclear protein

170 f cone inputs to the circuitry that mediates lateral inhibition is not cone-type specific, but whethe

171 Lateral inhibition is one of the key functions of Notch

172 naptic activity is required before effective lateral inhibition is recruited.

173 ctor, is sequestered apically at a time when lateral inhibition is required for patterning in the dev

174 A second model proposes that lateral inhibition is sufficient to select a single R8 f

175 Notch-mediated lateral inhibition is the proposed mechanism for creatin

176 f auditory processing in which broadly tuned lateral inhibition is used to limit excitatory receptive

177 positive feedback associated with widespread lateral inhibition, is mediated by the cortical neural n

178 tation--reciprocal inhibition of feedforward lateral inhibition--is structurally the simplest, and it

179 nt downstream mediators of Notch function in lateral inhibition, it is not known what genes function

180 ty represents the process by which effective lateral inhibition leads to diversification of progenito

181 bryonic cells and tissues that develop after lateral inhibition, like the connectives and commissures

182 Lateral inhibition may be a general mechanism behind the

183 In the olfactory bulb, lateral inhibition may occur between odorant receptor-sp

184 Intraglomerular lateral inhibition may play a key role in olfactory proc

185 t of a self-forming pattern, emerging from a lateral inhibition mechanism determined by a network of

186 fashion in the pronephros, suggesting that a lateral inhibition mechanism may play a role in their di

187 then participates in a negative feedback and lateral inhibition mechanism that defines the precise pa

188 The truncated MYB encoded by CPC mediates a lateral inhibition mechanism to negatively regulate WER,

189 ly, the interaction along scale implements a lateral inhibition mechanism, a canonical principle that

190 rol endocrine cell differentiation through a lateral inhibition mechanism; and that alpha and beta ce

191 imary or secondary fate using one of several lateral inhibition mechanisms.

192 This choice is under the control of lateral inhibition mediated by a Suppressor of Hairless-

193 potential to become sensory hair cells, and lateral inhibition mediated by Delta-Notch signaling res

194 ault in the absence of Notch activation, and lateral inhibition mediated by Delta-Notch signalling is

195 Lateral inhibition mediated by Delta/Notch (Dl/N) signal

196 in different networks engage in long-lasting lateral inhibition mediated by dendrodendritic synapses

197 ductive cellular determination signal, while lateral inhibition mediated by Notch antagonizes this ac

198 Lateral inhibition mediated by Notch is thought to gener

199 The importance of lateral inhibition mediated by NOTCH signaling is well d

200 ion of this complex cellular mosaic requires lateral inhibition mediated by Notch signaling.

201 toreceptor interactions were consistent with lateral inhibition mediated by retinal horizontal cells

202 ted from proneural clusters via a process of lateral inhibition mediated by the Notch signaling pathw

203 ay serve to modulate, over a long timescale, lateral inhibition mediated by these cells.

204 Mathematical modeling predicts that lateral inhibition, mediated by Notch signaling, functio

205 Lateral inhibition, mediated by Notch signaling, leads t

206 Second, lateral inhibition, mediated by the neurogenic genes, ac

207 have used computer modelling to test whether lateral inhibition might transform an initial population

208 In support of the standard lateral inhibition model, both continuous and Hes5-regul

209 Unlike a standard lateral inhibition model, our picture implies that R8s a

210 in contrast to the predictions of classical lateral inhibition models.

211 nderlying the regulation of neurogenesis and lateral inhibition of boundary cell formation by Wnt1 ha

212 on selectivity, and we show that it includes lateral inhibition of glutamatergic bipolar cells and se

213 ng MSX2 expression, which, in turn, leads to lateral inhibition of hair follicle formation within the

214 other photoreceptor fates and is involved in lateral inhibition of interommatidial bristles but is no

215 back loop between Notch and Delta leading to lateral inhibition of neighboring cells.

216 One early-acting mechanism is the lateral inhibition of neighbouring cells from acquiring

217 ections between glomeruli mediated only weak lateral inhibition of OSN inputs in slices and did not d

218 inhibition, and it attenuates the effect of lateral inhibition on the proneural cluster equivalence

219 tially form muscle progenitors, but owing to lateral inhibition, only one or two develop as such [2]

220 Differential effects of lateral inhibition onto MCs and TCs via distinct lateral

221 We found that lateral inhibition onto Off SACs from non-SAC amacrine c

222 In contrast, lateral inhibition onto On SACs is not necessary for dir

223 actory neural circuitry shows that decreased lateral inhibition onto projection neurons relaying sens

224 rons, increases the strength of M72-mediated lateral inhibition onto TCs, but not MCs, that project t

225 ne increased the strength of interglomerular lateral inhibition onto TCs, but not MCs, when the M72 g

226 istent with a theoretical model where either lateral inhibition or co-tuning can predominate, dependi

227 gh level of Neurog3 expression could mediate lateral inhibition or other unknown feedback mechanisms

228 prisingly, while misexpression of m6 impairs lateral inhibition, overexpression of m2 potentiates it,

229 itates the formation of sharp boundaries and lateral-inhibition patterns in models of development, an

230 both the early prosensory phase and a later lateral inhibition phase.

231 is sufficient to rescue neur function in the lateral inhibition process by which adult sensory organ

232 dence that Barbu can antagonize Notch during lateral inhibition processes in the embryonic mesoderm,

233 s cellular differentiation in Notch-mediated lateral inhibition processes, such that smaller cells ar

234 hancement of glycinergic IPSPs and transient lateral inhibition produced by a rotating windmill patte

235 Lateral inhibition produces the centre-surround organiza

236 rovided pure inhibition, consistent with the lateral inhibition proposed earlier.

237 romatin in equipotent progenitors undergoing lateral inhibition quickly enables distinct, transiently

238 We found that the lateral inhibition received by mitral cells is gated by

239 We propose that Notch mediated lateral inhibition regulates the relative numbers of spe

240 ontal cells to photoreceptors that generates lateral inhibition remains uncertain.

241 Lateral inhibition requires Delta signalling through Not

242 Lateral inhibition requires the Notch intracellular doma

243 Later, lateral inhibition restores the repression of neural dev

244 enesis, Notch ligands from nascent HCs exert lateral inhibition, restricting HC production.

245 h signalling within each such patch mediates lateral inhibition, restricting the proportion of cells

246 for many developmental processes, including lateral inhibition, segmentation, sex determination, dor

247 iety of spinal cord neurons, suggesting that lateral inhibition serves to diversify neuronal fate dur

248 the olfactory bulb in vitro and measured how lateral inhibition shapes correlations across timescales

249 on Ca(2+) imaging in awake mice to show that lateral inhibition shapes frequency tuning in primary au

250 ry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate.

251 ng, regardless of the presence or absence of lateral-inhibition signalling.

252 As the Wingless and lateral-inhibition signals are sequential [8], one might

253 cortical properties of localized processing, lateral inhibition, simultaneous contrast, and nonlinear

254 Without lateral inhibition, some cells acquire ectopic fates.

255 However, how this lateral inhibition system works at the molecular level i

256 erved for patterns with cellular homogeneity-lateral inhibition tends to give short-range patterns, w

257 imprecise rebound bursting; (2) TRN-mediated lateral inhibition that further desynchronizes firing in

258 It is also insensitive to the lateral inhibition that mediates the normal spacing of b

259 ompetition appears to involve Notch-mediated lateral inhibition that prevents extra cells from assumi

260 The role of the Notch pathway during the lateral inhibition that underlies binary cell fate choic

261 As in lateral inhibition, the metalloprotease Kuzbanian, the E

262 tory-specific transcription factor, controls lateral inhibition through delta-like notch ligand genes

263 e speculate that mGluRs amplify spike-driven lateral inhibition through the mitral-to-granule cell ci

264 me have long been proposed in the context of lateral inhibition through the Notch-Delta pathway, some

265 Transient lateral inhibition (TLI), the suppression of responses o

266 tine crypts, where notch signalling mediates lateral inhibition to assign progenitor cells into absor

267 is dynamic regulation allows the strength of lateral inhibition to be enhanced between cells with cor

268 additional mechanisms operate downstream of lateral inhibition to eliminate patterning errors in the

269 tributions of these two forms of presynaptic lateral inhibition to ganglion cell light sensitivity by

270 hese events act together with the process of lateral inhibition to generate precursor cells (neurobla

271 previous models require local excitation and lateral inhibition to maintain spatially localized persi

272 Feedback models rely on lateral inhibition to refine selectivity relative to a w

273 ofugal systems work together with widespread lateral inhibition to regulate subcortical frequency pro

274 theoretical explanations ranging from simple lateral inhibition to those based on the influence of kn

275 tationary edges on any surrounds, ruling out lateral inhibition-type explanations.

276 Proneural enhancement and lateral inhibition use similar ligand binding and recept

277 However, circuits in which the strength of lateral inhibition varies with the relative strength of

278 Cell fate determination by lateral inhibition via Notch/Delta signalling has been e

279 ing behavior emerges from the interaction of lateral inhibition (via the surround pathways), which is

280 thermore, the network suppression underlying lateral inhibition was blocked by inactivation of somato

281 The observed lateral inhibition was entirely dependent on circuitry w

282 However, lateral inhibition was not uniformly larger during a par

283 binoid (eCB) signaling, whereas MSN-mediated lateral inhibition was unaffected.

284 In the absence of nasal airflow, lateral inhibition was weaker in mitral cells and less m

285 as been thought to arise from an increase in lateral inhibition, we find that the inhibition that cel

286 ication has been well studied in the case of lateral inhibition, where ligand binding at the cell sur

287 bipotential progenitors is then governed by lateral inhibition, where Notch>Hes1-mediated Ngn3 prote

288 rk for an updated model of the intrastriatal lateral inhibition, where we explore its contribution to

289 some theories invoke enhancement of edges by lateral inhibition, whereas others rely on transients ca

290 Lateral inhibition, wherein a single cell signals to its

291 to cone signals is horizontal-cell-mediated lateral inhibition, which imparts a spatially antagonist

292 Such lateral inhibition, which is a universal feature of sens

293 particular circuit element, interglomerular lateral inhibition, which is known to be critical for a

294 pared the effects of blocking just the known lateral inhibition with blocking all GABAergic inhibitio

295 n of a repressive patterning signal, such as lateral inhibition, with continued developmental plastic

296 k connections between areas, and short-range lateral inhibition within each area.

297 ogenic effects during embryogenesis, loss of lateral inhibition within proneural cell clusters, and a

298 e notum, truncated Mam results in failure of lateral inhibition within proneural clusters and perturb

299 This induces lateral inhibition, yielding a pattern in which each Del

300 We show that lateral inhibition yields robustness to changes in prepa